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Chickenpox

Categories: Immune diseases, Infectious diseases, Reproductive diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Chickenpox

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MalaCards integrated aliases for Chickenpox:

Name: Chickenpox 12 74 42 3 43 15 62 17 71
Varicella 12 54 15

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases Immune diseases Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8659
ICD9CM 34 052
MeSH 43 D002644
NCIt 49 C97132
SNOMED-CT 67 38907003
ICD10 32 B01 B01.8 B01.9
UMLS 71 C0008049
Sources

Summaries for Chickenpox

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MedlinePlus : 42 Chickenpox is an infection caused by the varicella-zoster virus. Most cases are in children under age 15, but older children and adults can get it. It spreads very easily from one person to another. The classic symptom of chickenpox is an uncomfortable, itchy rash. The rash turns into fluid-filled blisters and eventually into scabs. It usually shows up on the face, chest, and back and then spreads to the rest of the body. Other symptoms include Fever Headache Tiredness Loss of appetite Chickenpox is usually mild and lasts 5 to 10 days. Calamine lotions and oatmeal baths can help with itching. Acetaminophen can treat the fever. Do not use aspirin for chickenpox; that combination can cause Reye syndrome. Chickenpox can sometimes cause serious problems. Adults, babies, teenagers, pregnant women, and those with weak immune systems tend to get sicker from it. They may need to take antiviral medicines. Once you catch chickenpox, the virus usually stays in your body. You probably will not get chickenpox again, but the virus can cause shingles in adults. A chickenpox vaccine can help prevent most cases of chickenpox, or make it less severe if you do get it. Centers for Disease Control and Prevention

MalaCards based summary : Chickenpox, also known as varicella, is related to herpes zoster and salivary gland disease, and has symptoms including fever, myalgia and anorexia. An important gene associated with Chickenpox is GYPC (Glycophorin C (Gerbich Blood Group)), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are cellular and cardiovascular system

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Human herpesvirus 3, which is transmitted by direct contact with secretions from the rash, or transmitted by droplet spread of respiratory secretions. The infection has symptom anorexia, has symptom myalgia, has symptom nausea, has symptom fever, has symptom headache, has symptom sore throat, and has symptom blisters.

CDC : 3 Chickenpox is a highly contagious disease caused by the varicella-zoster virus (VZV). It can cause an itchy, blister-like rash. The rash first appears on the chest, back, and face, and then spreads over the entire body, causing between 250 and 500 itchy blisters. Chickenpox can be serious, especially in babies, adolescents, adults, pregnant women, and people with a weakened immune system. The best way to prevent chickenpox is to get the chickenpox vaccine.

PubMed Health : 62 About chickenpox: Chickenpox is a highly contagious viral infection which mainly affects children. Typical symptoms include a very itchy skin rash with red blisters and a mild fever. Because most children are now vaccinated, chickenpox (also referred to as varicella) is much less common than it was in the past. If someone comes down with chickenpox, they are contagious after just one or two days, which is before they have a visible rash. But taking precautions and improving hygiene can help to avoid infecting others. Although chickenpox is unpleasant, it rarely has any serious consequences in children who are otherwise healthy. But it may become more severe in newborns and adults, as well as people who have a weakened immune system.

Wikipedia : 74 Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with... more...

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Related Diseases for Chickenpox

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Diseases related to Chickenpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1304)
# Related Disease Score Top Affiliating Genes
1 herpes zoster 32.9 TNFRSF1B TNF IL2 ICOSLG GYPC CRP
2 salivary gland disease 32.1 TNF ICOSLG CD8A CD40LG CD4 CCR6
3 measles 31.5 TNF IL6 IL2 CD40LG
4 neuroretinitis 31.3 CRP CD40LG CD4
5 purpura 31.3 TNF IL6 CRP CD40LG
6 mumps 31.1 TNFRSF1B TNF IL6 IL2 CD40LG
7 keratitis, hereditary 31.1 TNF IL6 CD8A CD4 CCR6
8 genital herpes 31.0 GYPC CD8A CD4 CCR6
9 streptococcal toxic-shock syndrome 31.0 TNF IL6 IL2
10 graft-versus-host disease 31.0 TNF IL6 IL2
11 parotitis 31.0 CRP CD40LG CD4 ALB
12 fasciitis 31.0 TNF IL6 IL2 ACTC1
13 rubella 31.0 TNFRSF1B TNF IL6 IL2 CD40LG
14 acute retinal necrosis syndrome 31.0 GYPC CD8A CD40LG CD4
15 facial paralysis 30.9 CRP CD8A CD40LG CD4 ALB
16 retinal vasculitis 30.9 TNFRSF1B CD40LG CCR6
17 transverse myelitis 30.8 TNF IL6 CD27
18 erythema multiforme 30.8 TNF IL6 IL2
19 aseptic meningitis 30.8 TNF CD40LG ADA
20 monkeypox 30.8 CD8A CD40LG CD4
21 vasculitis 30.8 TNFRSF1B TNF IL6 CRP CD40LG
22 chronic graft versus host disease 30.7 CD4 ALB
23 uveitis 30.7 TNFRSF1B TNF IL6 IL2
24 scarlet fever 30.7 TNF CRP CD40LG ALB
25 cytomegalovirus retinitis 30.7 TNF CD8A CD4
26 necrotizing fasciitis 30.7 IL6 IL2 CRP ALB
27 pars planitis 30.7 IL2 CD27 CCR6
28 cold agglutinin disease 30.7 IL6 CRP
29 ileus 30.7 TNF IL6 CRP
30 thrombophlebitis 30.7 CRP CD40LG ALB
31 conjunctivitis 30.6 TNF IL6 IL2
32 cranial nerve palsy 30.6 CRP CD40LG CD4 ALB
33 cardiac tamponade 30.6 CRP ALB ADA
34 poliomyelitis 30.6 TNF CD8A CD40LG CD4
35 congenital toxoplasmosis 30.6 CD8A CD40LG CD4
36 myelitis 30.6 TNF IL6 ICOSLG CD40LG CD27 CCR6
37 thrombocytopenic purpura, autoimmune 30.6 ICOSLG CD40LG CD4 CD19 CCR6
38 viral pneumonia 30.6 TNF IL6 CRP CD8A CD4
39 diphtheria 30.6 TNF IL2 CD40LG ALB
40 secondary syphilis 30.6 CD8A CD40LG CD4
41 allergic hypersensitivity disease 30.5 TNF IL2 ICOSLG CD4 CCR6
42 fournier gangrene 30.5 CD40LG ALB
43 cryptosporidiosis 30.5 CD8A CD40LG CD4
44 choroiditis 30.5 TNF CD40LG CD4
45 relapsing-remitting multiple sclerosis 30.5 TNF IL6 IL2 CD40LG CCR6
46 guillain-barre syndrome 30.5 TNFRSF1B TNF CD40LG ALB
47 neuromyelitis optica 30.5 IL6 CD40LG CD27
48 pleural empyema 30.5 CRP CD40LG CD4 ALB ADA
49 cerebrovascular disease 30.5 TNF IL6 CRP CD40LG
50 dermatitis 30.5 TNF IL6 IL2 CCR6

Graphical network of the top 20 diseases related to Chickenpox:



Diseases related to Chickenpox
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Symptoms & Phenotypes for Chickenpox

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Symptoms:

12
  • • fever
  • • myalgia
  • • anorexia
  • • headache
  • • nausea
  • • sore throat
  • • blisters

UMLS symptoms related to Chickenpox:


fever, pruritus, exanthema

MGI Mouse Phenotypes related to Chickenpox:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 ACTC1 ADA ALB CD19 CD27 CD4
2 cardiovascular system MP:0005385 10.23 ACTC1 ADA ALB CCR6 CD19 CD40LG
3 hematopoietic system MP:0005397 10.17 ADA CCR6 CD19 CD27 CD4 CD40LG
4 homeostasis/metabolism MP:0005376 10.1 ACTC1 ADA ALB CCR6 CD19 CD4
5 endocrine/exocrine gland MP:0005379 10.07 ADA ALB CD4 CD40LG CD8A IL2
6 immune system MP:0005387 10.03 ADA ALB CCR6 CD19 CD27 CD4
7 digestive/alimentary MP:0005381 10.01 ADA ALB CD19 CD4 IL2 IL6
8 neoplasm MP:0002006 9.5 ALB CD19 IL2 IL6 PGR TNF
9 normal MP:0002873 9.28 ACTC1 ADA ALB CCR6 CD19 CD4
Sources

Drugs & Therapeutics for Chickenpox

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PubMed Health treatment related to Chickenpox: 62

The treatment usually focuses on relieving the symptoms of chickenpox . In more severe cases, or if there is a greater risk of complications, antiviral drugs can be used to fight off the virus. Lotions, gels and powders are often applied in order to relieve itching and dry out the blisters . Most of them contain tanins, zinc , menthol or polidocanol . Sometimes oral medication like antihistamines is also recommended to stop the itching. But there is no good-quality scientific research on how effective they are. Symptoms like fever or aching muscles can be relieved using medicine that contains acetaminophen (paracetamol). The painkiller ibuprofen is not suitable for children with chickenpox . Children and teenagers should only take acetylsalicylic acid (ASA, the drug in medicines like Aspirin ) if it has been prescribed by a doctor, and only as a last resort. This is because it can cause a rare but dangerous side effect called Reye’s syndrome in children and teenagers.

Drugs for Chickenpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 174)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Ethanol Approved Phase 4 64-17-5 702
7
Budesonide Approved Phase 4 51333-22-3 63006 5281004
8
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
9
Interferon beta-1b Approved Phase 4 145155-23-3
10
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
11
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
12
Racepinephrine Approved Phase 4 329-65-7 838
13
Certolizumab pegol Approved Phase 4 428863-50-7
14
Mercaptopurine Approved Phase 4 50-44-2 667490
15
Adalimumab Approved Phase 4 331731-18-1 16219006
16
Azathioprine Approved Phase 4 446-86-6 2265
17
Infliximab Approved Phase 4 170277-31-3
18
Tofacitinib Approved, Investigational Phase 4 477600-75-2
19
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
20
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
21
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
22 Hormone Antagonists Phase 4
23 glucocorticoids Phase 4
24 Hormones Phase 4
25 Antineoplastic Agents, Hormonal Phase 4
26 Methylprednisolone Acetate Phase 4
27 Vaccines Phase 4
28 Anti-Asthmatic Agents Phase 4
29 Respiratory System Agents Phase 4
30 Autonomic Agents Phase 4
31 Anti-Inflammatory Agents Phase 4
32 Bronchodilator Agents Phase 4
33 Anti-Infective Agents, Local Phase 4
34 Dermatologic Agents Phase 4
35 (T,G)-A-L Phase 4
36 Fingolimod Hydrochloride Phase 4
37 Interferon-beta Phase 4
38 interferons Phase 4
39
Glatiramer Acetate Phase 4 147245-92-9 3081884
40 Epinephryl borate Phase 4
41 Anti-Allergic Agents Phase 4
42 Antiviral Agents Phase 4
43 valacyclovir Phase 4
44 Mesalamine Phase 4 89-57-6
45 polysaccharide-K Phase 4
46 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
47 Protein Kinase Inhibitors Phase 4
48 Janus Kinase Inhibitors Phase 4
49
Methylene blue Approved, Investigational Phase 3 61-73-4
50
Altretamine Approved Phase 3 645-05-6 2123

Interventional clinical trials:

(show top 50) (show all 263)
# Name Status NCT ID Phase Drugs
1 A Study of Immune Persistence After Inoculated With One-dose Freeze-dried Live Attenuated Varicella Vaccine in Children Aged 1-6 Years Unknown status NCT01982409 Phase 4
2 Study on Effectiveness of 2-dose Live Attenuated Varicella Vaccine Unknown status NCT02146469 Phase 4
3 Phase 4 Study of the Varicella Vaccine After the 2nd Dose Vaccination Unknown status NCT01830283 Phase 4
4 Phase 4 Study of Live Attenuated Varicella Vaccine After the 2 Doses Vaccination Unknown status NCT01866566 Phase 4
5 Safety and Immunogenicity of Live Attenuated Herpes Zoster Vaccine in Patients Undergoing Living Donor Kidney Transplantations Unknown status NCT00940940 Phase 4
6 A Pilot Study to Characterize the Immune Response Induced by a Commercial Varicella Zoster Virus Vaccine in Healthy Adult Females in Nairobi, Kenya. Unknown status NCT02514018 Phase 4
7 Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children Unknown status NCT00494624 Phase 4 prednisolone
8 A Study to Evaluate the Immunogenicity and Safety of 2 Doses of Live Attenuated Varicella Vaccine Completed NCT01817270 Phase 4
9 Rates of Seroconversion Following Varicella Vaccination of Asthmatic Children Between the Ages of One and Eight Years Treated With Pulmicort Respules® Versus Non-Steroidal Conventional Asthma Therapy Completed NCT00641446 Phase 4 budesonide;varicella zoster virus
10 A Study to Evaluate the Immunogenicity and Safety of 2 Doses of Live Attenuated Varicella Vaccine Completed NCT02173899 Phase 4
11 Blinded, Randomised Study to Assess the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Live Attenuated Measles-mumps-rubella-varicella Candidate Vaccine When Given to Healthy Children in Their Second Year of Life Completed NCT00126997 Phase 4
12 A Study to Evaluate the Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Live Attenuated JE Vaccine Completed NCT01815073 Phase 4
13 Safety of a Second Dose of Biken's Varicella Vaccine Administered at 4 to 6 Years of Age in Healthy Children in Argentina Completed NCT00830648 Phase 4
14 A Double-blind, Randomised, Controlled, Multi-centre Safety Study of a Refrigerator-stable Formulation of VARIVAX® in Healthy 12 to 15 Month-old Infants. Completed NCT00432731 Phase 4
15 Evaluation of Safety and Immunogenicity Receiving Live Attenuated Vaccine Against Varicella Without Gelatin Completed NCT01684072 Phase 4
16 An Open, Multicenter Study of the Safety and Tolerability of VAQTA(TM) and ProQuad(TM) in Healthy Children 12 to 23 Months of Age Completed NCT00326183 Phase 4
17 Live Attenuated Varicella Vaccine: A New Effective Adjuvant Weapon in the Battlefield Against Severe Resistant Psoriasis, a Randomized Controlled Trial Completed NCT01356004 Phase 4 live attenuated chicken pox vaccine;saline, efficacy
18 The Immunogenicity of Varicella-zoster Virus Vaccine in HIV-infected Children Completed NCT01138215 Phase 4
19 T Cell Responses to Varicella Zoster Virus After Vaccination and Viral Escape Completed NCT01911065 Phase 4
20 Safety and Immunogenicity of Measles Vaccine, Varicella Vaccine and Hepatitis-A Vaccine in HIV-exposed and HIV-unexposed South African Children Completed NCT03330171 Phase 4
21 Immunogenicity and Safety of a Herpes Zoster Vaccine (Zostavax) in Patients With Systemic Lupus Erythematosus: a Randomized Controlled Trial Completed NCT02477150 Phase 4
22 An Open, Randomized, Multicenter Study of the Safety, Tolerability, & Immunogenicity of VAQTAâ„¢ Given Concomitantly With PROQUADâ„¢ and PREVNARâ„¢ in Healthy Children 12 Months of Age Completed NCT00312858 Phase 4
23 Palatability Testing of a New Paediatric Formulation of Valacyclovir for the Prophylaxis and Treatment of VZV and HSV Infections in Children Completed NCT01682109 Phase 4 Valacyclovir
24 An Open-label, Single-arm, Phase IV Study Assessing the Immunogenicity and Safety of ZOSTAVAX® at Minimum Release Specification Approaching Expiry Potency in Subjects ≥50 Years Old. Completed NCT00681031 Phase 4
25 Immune Response to Shingles Vaccination Completed NCT02624375 Phase 4 Zoster Vaccine Live
26 Effectiveness Assessment of Vaccinating Schoolchildren Against Influenza the in São Paulo, 2009 Completed NCT01693380 Phase 4
27 Placebo Controlled Evaluation of the Cell Mediated Immune Response of Cirrhotic Subjects to Zostavaxâ„¢ Completed NCT02958345 Phase 4
28 The Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection Adaptive Immune Responses and Repertoire in Influenza Vaccination and Infection Completed NCT03453801 Phase 4
29 Immunogenicity and Safety of a Tetanus-diphtheria Vaccine and a 13-valent Pneumococcal Conjugate Vaccine After Concomitant Vaccination in ≥50-year-old Adults Completed NCT03552445 Phase 4
30 A 12-month, Prospective, Randomized, Active-controlled, Open-label Study to Evaluate the Patient Retention of Fingolimod vs. Approved First-line Disease Modifying Therapies in Adults With Relapsing Remitting Multiple Sclerosis (PREFERMS) Completed NCT01623596 Phase 4 Fingolimod;Disease Modifying therapy
31 Multicenter Randomised Controlled Trial of Episodic Fluticasone Versus Placebo in Viral-induced Asthma in Children Completed NCT00238927 Phase 4 inhaled fluticasone 750 mcg/day twice daily until 2 days without symptoms (maximum 15 consecutive days)
32 Double-Blind Placebo-Controlled Clinical Effectiveness Trial of the 23-Valent Pneumococcal Vaccine Among Military Trainees At Increased Risk of Respiratory Disease Completed NCT02079701 Phase 4
33 Occupational Exposure to Human Papilloma Virus (HPV) and Prophylactic Vaccination (Version IV Dated 24Oct2017) Recruiting NCT03350698 Phase 4
34 Safety and Tolerability of Herpes Zoster Vaccine in Patients With Rheumatoid Arthritis Immunized Prior to Biologics and Tofacitinib Therapy Initiation Recruiting NCT03016884 Phase 4
35 The Immunogenicity and Safety of Shingrix Vaccine in Patients With Moderate to Severe Ulcerative Colitis on Tofacitinib Recruiting NCT03591770 Phase 4
36 Long-term Suppressive Valacyclovir Treatment for Herpes Zoster Ophthalmicus Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
37 Safety and Immunogenicity of Recombinant Glycoprotein E Herpes Zoster Subunit (HZ/su) Vaccine in Renal Transplant Recipients Recruiting NCT03993717 Phase 4
38 Immunodeficiency in Cartilage-hair Hypoplasia: Correlation With Pulmonary Disease, Infections and Malignancy Active, not recruiting NCT02383797 Phase 4
39 Safety and Immunogenicity of Non-live, Recombinant Subunit Herpes Zoster Vaccine Before and After Lung Transplantation Active, not recruiting NCT03493776 Phase 4
40 Vaccinating Children After Chemotherapy for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study Active, not recruiting NCT02447718 Phase 4
41 Persistence of Varicella Immunity in Hospital Employees Receiving Varicella Vaccine Not yet recruiting NCT02026089 Phase 4
42 The Immunogenicity and Efficacy of Subunit Vaccine Against Herpes Zoster in RA Treated With JAK-inhibitors (VACCIMIL-ZOSTER) Not yet recruiting NCT03886038 Phase 4
43 A Double Blind Placebo-controlled Randomized Study of Varicella Zoster Vaccine in Patients With Moderate-to-severe Plaque Psoriasis Who Are Candidates for Biologic Therapy Terminated NCT02408159 Phase 4 Varicella Zoster Vaccine;Placebo
44 Induction and Maintenance of Immunity Against Varicella in Pediatric Orthotopic Liver Transplantation Recipients: a Retrospective and Prospective Nationwide Study in Switzerland Unknown status NCT00492739 Phase 2, Phase 3
45 Serological Evaluation of Chickenpox (Varicella) and Hepatitis A Vaccines Using Disposable Needle-Free Syringe Jet Injector (DSJI) Delivery Unknown status NCT00926419 Phase 2, Phase 3
46 Safety and Immunogenicity of Live Attenuated Oka/Merck Varicella Vaccine in Children Listed to Undergo Solid Organ Transplantation Unknown status NCT00213304 Phase 3
47 A Comparative Study of Tzanck Smear With Methylene Blue Versus Giemsa Stain to Diagnose Herpes Simplex, Herpes Zoster and Varicella Zoster Skin Infections Unknown status NCT03178747 Phase 3
48 A Phase II/III, Single-blind(Stage 1), Double-blinded(Stage 2), Randomized, Active-controlled, Dose-escalation(Stage 1), Non-inferiority(Stage 2) Study to Evaluate Immunogenicity and Safety of MG1111 in Healthy Children Unknown status NCT03375502 Phase 2, Phase 3 Varicella Vaccine
49 Clinical Evaluation of Valaciclovir Hydrochloride: 256U87 in Patients With Chickenpox - Open Uncontrolled Study. Completed NCT00169416 Phase 3 valaciclovir HCl granules
50 Pharmacokinetics and Safety of Famciclovir Oral Pediatric Formulation in Children 1-12 Years of Age With Varicella Zoster Infection Completed NCT00098046 Phase 3 famciclovir

Search NIH Clinical Center for Chickenpox

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Acyclovir
Acyclovir Sodium

Cochrane evidence based reviews: chickenpox

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Genetic Tests for Chickenpox

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Anatomical Context for Chickenpox

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The Foundational Model of Anatomy Ontology organs/tissues related to Chickenpox:

19
Skin

MalaCards organs/tissues related to Chickenpox:

40
Skin, T Cells, Testes, Bone, Liver, Bone Marrow, Lung
Sources

Publications for Chickenpox

About this section

Articles related to Chickenpox:

(show top 50) (show all 15113)
# Title Authors PMID Year
1
The Relationship Between Herpes Zoster, Syphilis and Chickenpox. 61 42
31688874 2019
2
Vaccination Coverage with Selected Vaccines and Exemption Rates Among Children in Kindergarten - United States, 2018-19 School Year. 61 42
31622283 2019
3
Immunogenicity, Safety, and Tolerability of Live Attenuated VaricellaZoster Virus Vaccine (ZOSTAVAXâ„¢) in Healthy Adults in India. 61 42
31325263 2018
4
[Adenosine deaminase deficiency associated severe combined immunodeficiency with disseminated varicella infection after vaccination: a case report]. 54 61
19099832 2008
5
[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]. 54 61
12604384 2003
6
New variant of varicella-zoster virus. 54 61
12498673 2002
7
Expression of the simian varicella virus glycoprotein E. 54 61
11551643 2001
8
Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants. 54 61
10027650 1999
9
Identification of immunodominant regions and linear B cell epitopes of the gE envelope protein of varicella-zoster virus. 54 61
8553555 1995
10
Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine. 54 61
7486953 1995
11
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine. 54 61
8045919 1994
12
Susceptibility of Oka varicella vaccine strain to antiviral drugs. 54 61
8310756 1993
13
Reactivation of pemphigus by varicella zoster virus after anti-CD20 treatment. 61
31840226 2020
14
Biphasic evolution of varicella-zoster virus meningoencephalitis : Diagnostic challenges. 61
31767157 2020
15
The darker side of varicella zoster infection: Arterial ischemic stroke. 61
31892633 2020
16
MULTIMODAL IMAGING IN ACUTE RETINAL NECROSIS PRESENTING WITH MACULAR INVOLVEMENT. 61
32032287 2020
17
Why are vaccines against many human viral diseases still unavailable; an historic perspective? 61
31502669 2020
18
Genital zoster in near term pregnancy: Case report and need of management guidelines. 61
31852623 2020
19
Exploring the relationship between newspaper coverage of vaccines and childhood vaccination rates in Spain. 61
32017659 2020
20
Microparticle-mediated VZV propagation and endothelial activation: Mechanism of VZV vasculopathy. 61
31892634 2020
21
Anti-herpesvirus prophylaxis, pre-emptive treatment or no treatment in adults undergoing allogeneic transplant for haematological disease: systematic review and meta-analysis. 61
31536817 2020
22
Accuracy, precision, and consistency of methods for pathogen-specific cerebrospinal fluid/serum Q-value calculation. 61
31678266 2020
23
Fifteen-minute consultation: Prevention and treatment of chickenpox in newborns. 61
31122930 2020
24
New approaches to controlling an outbreak of chickenpox in a large immigration detention setting in England: the role of serological testing and mathematical modelling. 61
32036802 2020
25
Women who received varicella vaccine versus natural infection have different long-term T cell immunity but similar antibody levels. 61
31959424 2020
26
Efficacy of plasma exchange with a high dose of acyclovir for disseminated varicella infection. 61
31520251 2020
27
Vaccination rate and immunity of children and adolescents with inflammatory bowel disease or autoimmune hepatitis in Germany. 61
31879123 2020
28
Assessment of the Clinical and Economic Impact of Different Immunization Protocols of Measles, Mumps, Rubella and Varicella in Internationally Adopted Children. 61
32024209 2020
29
Performance Characteristics of a Multiplex Flow Immunoassay for Detection of IgG-class Antibodies to Measles, Mumps, Rubella and Varicella-Zoster Viruses in Presumptively Immune Healthcare Workers. 61
32024728 2020
30
Hepatitis B Birth Dose Effects on Childhood Immunization in the U.S. 61
31959321 2020
31
Congenital viral infections in England over five decades: a population-based observational study. 61
31708420 2020
32
Vaccine-Strain Herpes Zoster Ophthalmicus in a 14-month-old Boy Prompting an Immunodeficiency Workup: Case Report and Review of Vaccine-strain Herpes Zoster. 61
31929435 2020
33
Reduced economic burden of AIDS-defining illnesses associated with adherence to antiretroviral therapy. 61
31740407 2020
34
Herpetic Panophthalmitis: A Diagnostic Dilemma. 61
30444434 2020
35
Causes of fever in pregnant women with acute undifferentiated fever: a prospective multicentric study. 61
31955353 2020
36
Vaccination coverage and immunity levels against vaccine-preventable diseases in male Air Force recruits in Greece. 61
31761499 2020
37
Usefulness of aqueous and vitreous humor analysis in infectious uveitis. 61
31994615 2020
38
[Anterior viral uveitis : Clinical aspects, diagnostic procedure and treatment options]. 61
31915909 2020
39
Erectile Dysfunction Secondary to Herpes Zoster. 61
32001867 2020
40
[Immunisation schedule of the Spanish Association of Paediatrics: 2020 recommendations]. 61
31901289 2020
41
Diagnosing inborn error of immunity following the presentation of a complicated acquired infection after MMRV vaccine administration. 61
31969413 2020
42
Is there an association between Stevens-Johnson Syndrome and vaccination? A systematic review. 61
31713580 2020
43
Viral reactivations following hematopoietic stem cell transplantation in pediatric patients - A single center 11-year analysis. 61
32017805 2020
44
Disseminated bullous impetigo and atopic dermatitis: Case series and literature review. 61
31755570 2020
45
Manipulation of the Innate Immune Response by Varicella Zoster Virus. 61
32038653 2020
46
Polymerase chain reaction for the diagnosis of herpesvirus infections in dermatology : Analysis of clinical data. 61
31820101 2020
47
Varicella-zoster virus infection in children with autologous hematopoietic cell transplantation: A retrospective, single-center study in Korea. 61
31962166 2020
48
Seeking the optimal schedule for chickenpox vaccination in Canada: Using an agent-based model to explore the impact of dose timing, coverage and waning of immunity on disease outcomes. 61
31735499 2020
49
Eosinophils are surprisingly common in biopsy specimens of cutaneous herpes simplex virus and varicella zoster virus infections: Results of a comprehensive histopathologic and clinical appraisal. 61
31441947 2020
50
The clinical and economic burden of varicella in the Middle East: a systematic literature review. 61
31373864 2020
Sources

Variations for Chickenpox

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Expression for Chickenpox

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Search GEO for disease gene expression data for Chickenpox.
Sources

Pathways for Chickenpox

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Pathways related to Chickenpox according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.97 TNFRSF1B TNF MUC1 IL6 IL2 ICOSLG
2
Akt Signaling 63
Show member pathways
 13.37 TNFRSF1B TNF IL6 IL2 CD40LG CD4
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.31 TNFRSF1B TNF MUC1 IL6 IL2 CD40LG
4
PAK Pathway 63
Show member pathways
 13.24 TNFRSF1B TNF IL6 IL2 CD40LG CD4
5
Allograft rejection 1 36
Show member pathways
 12.72 TNF IL6 IL2 ICOSLG CD8A CD40LG
6
NF-KappaB Family Pathway 63
Show member pathways
 12.66 TNFRSF1B TNF IL6 IL2 CD40LG
7
4-1BB Pathway 63
Show member pathways
 12.62 TNFRSF1B TNF CD40LG CD4 CD27
8
Immune response NFAT in immune response 22
Show member pathways
 12.57 TNFRSF1B TNF IL2 ICOSLG CD40LG CD4
9
T cell receptor signaling pathway 36
Show member pathways
 12.53 TNF IL6 IL2 CD8A CD40LG CD4
10
NF-kappaB Signaling 4
12.47 TNFRSF1B TNF IL2 CD8A CD40LG CD19
11
Human T-cell leukemia virus 1 infection 36
12.29 TNF IL6 IL2 CD4
12
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.29 TNFRSF1B TNF IL6 IL2 CCR6
13
Folate Metabolism 1
Show member pathways
 12.28 TNF IL6 IL2 CRP ALB
14
Cell adhesion molecules (CAMs) 36
12.08 ICOSLG CD8A CD40LG CD4
15
Th1 Differentiation Pathway 64
Show member pathways
 12.02 TNF IL6 IL2 CD4
16
Interleukin-4 and 13 signaling 65
11.94 TNFRSF1B TNF MUC1 IL6
17
Hematopoietic cell lineage 36
11.76 TNF IL6 CD8A CD4 CD19
18
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.72 TNF IL2 CD40LG
19
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.7 TNFRSF1B TNF CD40LG
20
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.7 TNF IL6 IL2 CD8A CD4 CD19
21
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.68 TNF IL6 IL2
22
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.61 TNF IL2 CD8A
23
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 TNF IL6 IL2 CD40LG
24
T Cell Co-Signaling Pathway: Ligand-Receptor Interactions 64
11.58 ICOSLG CD40LG CD27
25
Innate Lymphoid Cell Differentiation Pathways 64
11.56 TNF IL2 CD8A CD4 CCR6
26
Photodynamic therapy-induced AP-1 survival signaling. 1
11.52 TNF IL6 IL2
27
Interleukin-10 signaling 65
11.49 TNFRSF1B TNF IL6
28
B Cell Development Pathways 64
11.48 CD40LG CD4 CD27 CD19
29
Malaria 36
11.4 TNF IL6 GYPC CD40LG
30
Inflammatory Response Pathway 1
11.29 TNFRSF1B IL2 CD40LG
31
Cytokines and Inflammatory Response 1
11.09 TNF IL6 IL2 CD4
32
Overview of nanoparticle effects 1
10.98 TNF IL6 CRP
33
Dendritic Cells Developmental Lineage Pathway 64
10.97 TNF IL6 IL2 CD8A CD4 CD19
34
Primary immunodeficiency 36
10.93 CD8A CD40LG CD4 CD19 ADA
Sources

GO Terms for Chickenpox

About this section

Cellular components related to Chickenpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.18 TNFRSF1B TNF MUC1 ICOSLG GYPC DOCK8
2 extracellular region GO:0005576 9.96 TNFRSF1B TNF MUC1 IL6 IL2 CRP
3 integral component of plasma membrane GO:0005887 9.81 TNF MUC1 GYPC CD8A CD40LG CD4
4 cell surface GO:0009986 9.8 TNF CD40LG CD4 CD27 CCR6 ADA
5 membrane raft GO:0045121 9.71 TNFRSF1B TNF CD4 CD19
6 extracellular space GO:0005615 9.65 TNF MUC1 MIR122 IL6 IL2 CRP
7 external side of plasma membrane GO:0009897 9.28 TNF ICOSLG CD8A CD40LG CD4 CD27

Biological processes related to Chickenpox according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.89 TNFRSF1B TNF IL6 CRP CD40LG
2 cell surface receptor signaling pathway GO:0007166 9.87 TNFRSF1B CD8A CD4 CD27
3 negative regulation of apoptotic process GO:0043066 9.87 IL6 IL2 CD40LG CD27 ALB ADA
4 regulation of immune response GO:0050776 9.85 ICOSLG CD8A CD40LG CD19
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.73 TNFRSF1B TNF CD40LG CD27
6 cytokine-mediated signaling pathway GO:0019221 9.73 TNFRSF1B TNF MUC1 IL6 IL2 CD4
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TNF IL6 IL2
8 humoral immune response GO:0006959 9.69 TNF IL6 CCR6
9 positive regulation of T cell proliferation GO:0042102 9.67 IL6 IL2 CD40LG CD4
10 extrinsic apoptotic signaling pathway GO:0097191 9.63 TNFRSF1B TNF CD27
11 positive regulation of T cell differentiation GO:0045582 9.58 IL2 CD27 ADA
12 regulation of neuroinflammatory response GO:0150077 9.56 TNFRSF1B IL6
13 negative regulation of T cell apoptotic process GO:0070233 9.52 DOCK8 CD27
14 regulation of immunoglobulin secretion GO:0051023 9.48 TNF CD40LG
15 T cell activation GO:0042110 9.46 ICOSLG CD8A CD4 ADA
16 immune response GO:0006955 9.23 TNFRSF1B TNF IL6 IL2 CD8A CD40LG
17 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP

Molecular functions related to Chickenpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 TNFRSF1B TNF PGR MUC1 IL6 IL2
2 cytokine activity GO:0005125 9.26 TNF IL6 IL2 CD40LG
Sources

Sources for Chickenpox

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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