MCID: CHC001
MIFTS: 60

Chickenpox

Categories: Immune diseases, Infectious diseases, Reproductive diseases, Skin diseases
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Aliases & Classifications for Chickenpox

Summaries for Chickenpox

MedlinePlus: 41 Chickenpox is an infection caused by the varicella-zoster virus. Most cases are in children under age 15, but older children and adults can get it. It spreads very easily from one person to another. The classic symptom of chickenpox is an uncomfortable, itchy rash. The rash turns into fluid-filled blisters and eventually into scabs. It usually shows up on the face, chest, and back and then spreads to the rest of the body. Other symptoms include: Fever Headache Tiredness Loss of appetite Chickenpox is usually mild and lasts 5 to 10 days. Calamine lotions and oatmeal baths can help with itching. Acetaminophen can treat the fever. Do not use aspirin for chickenpox; that combination can cause Reye syndrome. Chickenpox can sometimes cause serious problems. Adults, babies, teenagers, pregnant women, and those with weak immune systems tend to get sicker from it. They may need to take antiviral medicines. Once you catch chickenpox, the virus usually stays in your body. You probably will not get chickenpox again, but the virus can cause shingles in adults. A chickenpox vaccine can help prevent most cases of chickenpox, or make it less severe if you do get it. Centers for Disease Control and Prevention

MalaCards based summary: Chickenpox, also known as varicella, is related to herpes zoster and human cytomegalovirus infection, and has symptoms including fever, anorexia and myalgia. An important gene associated with Chickenpox is GYPC (Glycophorin C (Gerbich Blood Group)), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Ethanol and Aluminum hydroxide have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and bone marrow, and related phenotypes are homeostasis/metabolism and normal

PubMed Health : 63 Chickenpox: Chickenpox is a highly contagious viral infection which mainly affects children. Typical symptoms include a very itchy skin rash with red blisters and a mild fever. Because most children are now vaccinated, chickenpox (also referred to as varicella) is much less common than it was in the past. If someone comes down with chickenpox, they are contagious after just one or two days, which is before they have a visible rash. But taking precautions and improving hygiene can help to avoid infecting others. Although chickenpox is unpleasant, it rarely has any serious consequences in children who are otherwise healthy. But it may become more severe in newborns and adults, as well as people who have a weakened immune system.

CDC: 2 Chickenpox is a highly contagious disease caused by the varicella-zoster virus (VZV). It can cause an itchy, blister-like rash. The rash first appears on the chest, back, and face, and then spreads over the entire body, causing between 250 and 500 itchy blisters. Chickenpox can be serious, especially in babies, adolescents, adults, pregnant women, and people with a weakened immune system. The best way to prevent chickenpox is to get the chickenpox vaccine.

Disease Ontology: 11 A viral infectious disease that results in infection located in skin, has material basis in Human herpesvirus 3, which is transmitted by direct contact with secretions from the rash, or transmitted by droplet spread of respiratory secretions. The infection has symptom anorexia, has symptom myalgia, has symptom nausea, has symptom fever, has symptom headache, has symptom sore throat, and has symptom blisters.

Wikipedia: 75 Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with... more...

Related Diseases for Chickenpox

Diseases related to Chickenpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1628)
# Related Disease Score Top Affiliating Genes
1 herpes zoster 32.6 IL2 IL10 IFNG IFNA1 GYPC CD8A
2 human cytomegalovirus infection 31.5 TNF IL6 IL10 IFNB1 GYPC CD8A
3 measles 31.3 IL6 IL2 IFNB1 IFNA1
4 keratitis, hereditary 31.1 TNF IL6 IL10 CD8A CD4 CCR6
5 smallpox 31.0 TNF IL4 IL2 IFNG
6 vaccinia 30.9 TNF IL6 IL2 IFNB1 IFNA1
7 graft-versus-host disease 30.9 TNF IL2 IL10 IFNG
8 radiculopathy 30.9 IL6 IL10 IFNA1 CRP
9 vasculitis 30.9 TNF IL6 IL10 CRP
10 mumps 30.9 TNF IL6 IL2 IL10 IFNG IFNB1
11 disseminated intravascular coagulation 30.8 TNF IL6 IL10 CRP
12 parotitis 30.8 CRP CD8A CD4 ALB
13 encephalitis 30.8 TNF IL6 IL10 IFNB1 IFNA1
14 acute retinal necrosis syndrome 30.7 TNF IL6 IL10 GYPC CD8A CD4
15 granulomatous angiitis 30.7 CRP CD8A CD4
16 headache 30.7 TNF IL2 ALB
17 inappropriate adh syndrome 30.7 IL6 CRP ALB
18 purpura 30.7 TNF IL6 IL4 IL2 IL10 IFNG
19 necrotizing fasciitis 30.7 TNF IL6 CRP ALB
20 pancreatitis 30.7 TNF IL6 IL10 CRP ALB
21 fasciitis 30.6 TNF IL6 IL2 IFNG IFNA1
22 rubella 30.6 TNF IL6 IL4 IL2 IL10 IFNG
23 retinal vasculitis 30.6 TNF IFNB1 CD4 CCR6
24 bell's palsy 30.6 TNF IL6 CRP CD8A CD4 ALB
25 adult syndrome 30.6 TNF IL6 CRP
26 cranial nerve palsy 30.6 TNF CRP CD4 ALB
27 bowel dysfunction 30.6 TNF IL6 IL10 CRP ALB
28 facial paralysis 30.6 TNF IL6 CRP CD8A CD4 ALB
29 polyarteritis nodosa 30.6 TNF IL6 CRP
30 pars planitis 30.6 IL2 CD27 CCR6
31 inflammatory bowel disease 1 30.5 TNF IL6 IL10 CCR6
32 paine syndrome 30.5 TNF IL6 IL10
33 acute disseminated encephalomyelitis 30.5 IL6 IFNB1 CRP CD8A CD4 CCR6
34 monkeypox 30.5 IFNA1 CD8A CD4
35 pleural empyema 30.5 IL6 CRP CD4 ALB ADA
36 scarlet fever 30.5 TNF IL6 CRP CD4 ALB
37 pericarditis 30.5 TNF IL6 IFNG CRP ADA ACE2
38 adult respiratory distress syndrome 30.5 TNF IL6 IL10 CRP CCR6 ACE2
39 myelitis 30.5 TNF IL6 IL10 IFNB1 CD27 CCR6
40 genital herpes 30.5 TNF IL2 IFNB1 IFNA1 GYPC CD8A
41 optic papillitis 30.5 TNF CRP CD4
42 pyoderma 30.5 TNF CRP CCR6
43 optic neuritis 30.5 TNF IL6 IL10
44 paralytic ileus 30.5 IL6 CRP ALB
45 herpes simplex 30.4 IFNB1 IFNA1 GYPC CD8A
46 spinal cord disease 30.4 TNF IL6 IL10 IFNB1 CD8A CD4
47 leukemia, acute lymphoblastic 30.4 IL2 CD8A CD4 CD19 CCR6 ADA
48 spondyloarthropathy 1 30.4 TNF IL6 IL10 CRP CD8A CD4
49 herpes simplex virus keratitis 30.4 IFNB1 GYPC CD8A CD4
50 ileus 30.4 TNF IL6 IL10 IFNG CRP

Graphical network of the top 20 diseases related to Chickenpox:



Diseases related to Chickenpox

Symptoms & Phenotypes for Chickenpox

Symptoms:

11
  • fever
  • anorexia
  • myalgia
  • headache
  • nausea
  • sore throat
  • blisters

UMLS symptoms related to Chickenpox:


fever; pruritus; exanthema

MGI Mouse Phenotypes related to Chickenpox:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 ACE2 ADA ALB CCR6 CD19 CD4
2 normal MP:0002873 10.19 ADA ALB CCR6 CD19 CD8A IFNA1
3 cellular MP:0005384 10.17 ACE2 ADA ALB CD19 CD27 CD4
4 neoplasm MP:0002006 10.11 ALB CD19 IFNB1 IFNG IL10 IL2
5 liver/biliary system MP:0005370 10.11 ADA ALB CD19 IFNG IL10 IL2
6 digestive/alimentary MP:0005381 10.11 ACE2 ADA ALB CD19 CD4 IFNG
7 immune system MP:0005387 10.11 ACE2 ADA ALB CCR6 CD19 CD27
8 endocrine/exocrine gland MP:0005379 10.1 ADA ALB CD4 CD8A IFNG IL10
9 no phenotypic analysis MP:0003012 10.02 CD4 IFNB1 IFNG IL10 IL2 IL4
10 cardiovascular system MP:0005385 10 ACE2 ADA ALB CCR6 CD19 CRP
11 respiratory system MP:0005388 9.61 ACE2 ADA IFNA1 IFNG IL10 IL2
12 hematopoietic system MP:0005397 9.55 ACE2 ADA CCR6 CD19 CD27 CD4

Drugs & Therapeutics for Chickenpox

PubMed Health treatment related to Chickenpox: 63

The treatment usually focuses on relieving the symptoms of chickenpox . In more severe cases, or if there is a greater risk of complications, antiviral drugs can be used to fight off the virus. Lotions, gels and powders are often applied in order to relieve itching and dry out the blisters . Most of them contain tanins, zinc , menthol or polidocanol . Sometimes oral medication like antihistamines is also recommended to stop the itching. But there is no good-quality scientific research on how effective they are. Symptoms like fever or aching muscles can be relieved using medicine that contains acetaminophen (paracetamol). The painkiller ibuprofen is not suitable for children with chickenpox . Children and teenagers should only take acetylsalicylic acid (ASA, the drug in medicines like Aspirin ) if it has been prescribed by a doctor, and only as a last resort. This is because it can cause a rare but dangerous side effect called Reye’s syndrome in children and teenagers.

Drugs for Chickenpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2
Aluminum hydroxide Approved, Investigational Phase 4 21645-51-2
3
Budesonide Approved Phase 4 51333-22-3 5281004 40000 63006
4
Carbamide peroxide Approved Phase 4 124-43-6
5
Arginine Approved, Investigational, Nutraceutical Phase 4 74-79-3 6322
6
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
7 Antiviral Agents Phase 4
8 Anti-Infective Agents Phase 4
9 Pharmaceutical Solutions Phase 4
10 Bronchodilator Agents Phase 4
11 Anti-Asthmatic Agents Phase 4
12 Hormones Phase 4
13 Hormone Antagonists Phase 4
14 glucocorticoids Phase 4
15 Respiratory System Agents Phase 4
16 Anti-Inflammatory Agents Phase 4
17 Immunoglobulins Phase 4
18 Antibodies Phase 4
19 Potassium phosphate Phase 4
20
Methylene blue Approved, Investigational Phase 3 61-73-4 6099
21
Altretamine Approved Phase 3 645-05-6 2123
22
Famciclovir Approved, Investigational Phase 3 104227-87-4 3324
23
Acyclovir Approved Phase 3 59277-89-3 2022
24
Sorbitol Approved, Investigational Phase 3 69-65-8, 50-70-4 453 6251 5780
25
Sorivudine Investigational Phase 3 77181-69-2
26 5-propynylarabinofuranosyluracil Phase 3
27 Somatomedin B Phase 3
28 Hemagglutinins Phase 3
29 Taxane Phase 3 108169
30
Acetic acid Approved Phase 2 64-19-7 176
31
Acalabrutinib Approved, Investigational Phase 2 1420477-60-6 71226663 71226662
32
D-Tyrosine Approved, Experimental, Investigational, Nutraceutical Phase 2 133585-56-5, 60-18-4, 556-02-5 1153 6057
33
Zuretinol acetate Investigational Phase 2 127-47-9, 29584-22-3 10245972
34 Immunologic Factors Phase 2
35 Heptavalent Pneumococcal Conjugate Vaccine Phase 2
36
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 1 67-97-0, 1406-16-2 5280795 10883523
37
Calcifediol Approved, Nutraceutical Phase 1 19356-17-3 5283731
38 Vitamins Phase 1
39 Calciferol Phase 1
40 Hydroxycholecalciferols Phase 1
41 Antibodies, Monoclonal Phase 1
42
Valaciclovir Approved, Investigational 124832-27-5, 124832-26-4 60773 135398742
43
Ascorbic acid Approved, Nutraceutical 50-81-7 54676860 54670067 5785
44 Immunoglobulin G
45 Immunoglobulins, Intravenous
46 gamma-Globulins
47 Rho(D) Immune Globulin
48 Antioxidants
49 Anti-Bacterial Agents
50 Antibiotics, Antitubercular

Interventional clinical trials:

(show top 50) (show all 158)
# Name Status NCT ID Phase Drugs
1 A Cross-over, Open-label, Single-group Study to Evaluate the Safety and Immunogenicity of Live Attenuated Varicella Vaccine Skyvaricella Injection (Inj.) Developed by SK Bioscience (Company Limited) Co., Ltd of South Korea in Healthy Volunteer Vietnamese Children From 12 Months to 12 Years Old Unknown status NCT04384016 Phase 4
2 A Study of Immune Persistence After Inoculated With One-dose Freeze-dried Live Attenuated Varicella Vaccine in Children Aged 1-6 Years Unknown status NCT01982409 Phase 4
3 Study on Effectiveness of 2-dose Live Attenuated Varicella Vaccine Unknown status NCT02146469 Phase 4
4 Phase 4 Study of Live Attenuated Varicella Vaccine After the 2 Doses Vaccination Unknown status NCT01866566 Phase 4
5 Safety and Immunogenicity of Measles Vaccine, Varicella Vaccine and Hepatitis-A Vaccine in HIV-exposed and HIV-unexposed South African Children Unknown status NCT03330171 Phase 4
6 Phase 4 Study of the Varicella Vaccine After the 2nd Dose Vaccination Unknown status NCT01830283 Phase 4
7 A Pilot Study to Characterize the Immune Response Induced by a Commercial Varicella Zoster Virus Vaccine in Healthy Adult Females in Nairobi, Kenya. Unknown status NCT02514018 Phase 4
8 Safety and Immunogenicity of Non-live, Recombinant Subunit Herpes Zoster Vaccine Before and After Lung Transplantation Unknown status NCT03493776 Phase 4
9 Evaluation of Safety and Immunogenicity Receiving Live Attenuated Vaccine Against Varicella Without Gelatin Completed NCT01684072 Phase 4
10 An Open, Multicenter Study of the Safety and Tolerability of VAQTA(TM) and ProQuad(TM) in Healthy Children 12 to 23 Months of Age Completed NCT00326183 Phase 4
11 A Study to Evaluate the Immunogenicity and Safety of 2 Doses of Live Attenuated Varicella Vaccine Completed NCT01817270 Phase 4
12 A Study to Evaluate the Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Live Attenuated JE Vaccine Completed NCT01815073 Phase 4
13 A Randomized, Controlled Clinical Trial to Evaluate the Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Inactivated Hepatitis A Vaccine Completed NCT05526820 Phase 4
14 Safety of a Second Dose of Biken's Varicella Vaccine Administered at 4 to 6 Years of Age in Healthy Children in Argentina Completed NCT00830648 Phase 4
15 Rates of Seroconversion Following Varicella Vaccination of Asthmatic Children Between the Ages of One and Eight Years Treated With Pulmicort Respules® Versus Non-Steroidal Conventional Asthma Therapy Completed NCT00641446 Phase 4 budesonide;varicella zoster virus
16 A Double-blind, Randomised, Controlled, Multi-centre Safety Study of a Refrigerator-stable Formulation of VARIVAX® in Healthy 12 to 15 Month-old Infants. Completed NCT00432731 Phase 4
17 T Cell Responses to Varicella Zoster Virus After Vaccination and Viral Escape Completed NCT01911065 Phase 4
18 Blinded, Randomised Study to Assess the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Live Attenuated Measles-mumps-rubella-varicella Candidate Vaccine When Given to Healthy Children in Their Second Year of Life Completed NCT00126997 Phase 4
19 The Immunogenicity of Varicella-zoster Virus Vaccine in HIV-infected Children Completed NCT01138215 Phase 4
20 A Study to Evaluate the Immunogenicity and Safety of 2 Doses of Live Attenuated Varicella Vaccine Completed NCT02173899 Phase 4
21 Live Attenuated Varicella Vaccine: A New Effective Adjuvant Weapon in the Battlefield Against Severe Resistant Psoriasis, a Randomized Controlled Trial Completed NCT01356004 Phase 4 live attenuated chicken pox vaccine;saline, efficacy
22 Palatability Testing of a New Paediatric Formulation of Valacyclovir for the Prophylaxis and Treatment of VZV and HSV Infections in Children Completed NCT01682109 Phase 4 Valacyclovir
23 A Clinical Trial to Evaluate Protective Effect, Safety and Immunogenicity of Live Attenuated Varicella Vaccine in Children Aged 1-12 Years Recruiting NCT05470855 Phase 4
24 A Randomized, Blind, Controlled Clinical Trial to Evaluate Safety and Immunogenicity of Live Attenuated Varicella Vaccine After a Two-dose Vaccination Course in Healthy Population Aged ≥13 Years Old Recruiting NCT05015686 Phase 4
25 An Open Clinical Trial to Evaluate the Immunity Persistence of Live Attenuated Varicella Vaccine at 5 and 8 Years After Primary Immunization With Live Attenuated Varicella Vaccine Not yet recruiting NCT05095701 Phase 4
26 An Open Clinical Trial to Evaluate Immunogenicity,Safety and Protective Effect of Live Attenuated Varicella Vaccine and a Clinical Trial on Antibody Level and Etiology of Varicella Zoster Virus in Zhejiang Province Not yet recruiting NCT05460429 Phase 4
27 VZV-specific Tissue Resident Memory T-cells After Shingrix Vaccination Not yet recruiting NCT04403139 Phase 4 Shingrix
28 A Double Blind Placebo-controlled Randomized Study of Varicella Zoster Vaccine in Patients With Moderate-to-severe Plaque Psoriasis Who Are Candidates for Biologic Therapy Terminated NCT02408159 Phase 4 Varicella Zoster Vaccine;Placebo
29 Persistence of Varicella Immunity in Hospital Employees Receiving Varicella Vaccine Withdrawn NCT02026089 Phase 4
30 Serological Evaluation of Chickenpox (Varicella) and Hepatitis A Vaccines Using Disposable Needle-Free Syringe Jet Injector (DSJI) Delivery Unknown status NCT00926419 Phase 2, Phase 3
31 A Comparative Study of Tzanck Smear With Methylene Blue Versus Giemsa Stain to Diagnose Herpes Simplex, Herpes Zoster and Varicella Zoster Skin Infections Unknown status NCT03178747 Phase 3
32 Clinical Evaluation of Valaciclovir Hydrochloride: 256U87 in Patients With Chickenpox - Open Uncontrolled Study. Completed NCT00169416 Phase 3 valaciclovir HCl granules
33 Safety and Immunogenicity Study of 2 Formulations of GSK Biologicals' Varicella Vaccines Given as a 2-dose Course in the Second Year of Life. Completed NCT02570126 Phase 3
34 Pharmacokinetics and Safety of Famciclovir Oral Pediatric Formulation in Children 1-12 Years of Age With Varicella Zoster Infection Completed NCT00098046 Phase 3 famciclovir
35 Open-Label BV-araU Treatment of Pediatric HIV-Infected Patients With Cutaneous, Visceral, or Ocular Varicella-Zoster Viral Disease Who Have Failed or Are Intolerant of Standard Therapy Completed NCT00002358 Phase 3 Sorivudine
36 Study in Healthy Children (<2 Years) to Evaluate the Safety and Efficacy of GSK Biologicals' Live Attenuated Varicella Vaccine (VarilrixTM) and of GSK Biologicals' Combined Measles-Mumps-Rubella-Varicella Vaccine Completed NCT00226499 Phase 3
37 A Double-Blind, Multicenter Study Comparing Oral 882C87 With Oral Acyclovir for Treatment of Localized Herpes Zoster in Immunocompromised Patients Completed NCT00002315 Phase 3 Netivudine;Acyclovir
38 Safety, Tolerability, and Immunogenicity of VARIVAX (2007 Commercial VZV Bulk Process) Administered Concomitantly With M-M-R II in Healthy Children 12-to-23 Months of Age Completed NCT00822237 Phase 3
39 Follow-up to Evaluate the the Immunogenicity & Safety of GSK Biologicals' MMRV Vaccine Given as a Two-dose Schedule in the Second Year of Life, as Compared to Separate Administration of GSK Biologicals' Priorix® & Varilrix®. Completed NCT00406211 Phase 3
40 An Immunogenicity and Safety Evaluation of Two Doses of Menactra® (Meningococcal [Groups A, C, Y and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) Given to Healthy Subjects at 9 and 12 Months of Age Completed NCT00384397 Phase 3
41 A Blind, Randomized and Controlled Clinical Trial to Evaluate the Protective Effect, Safety and Immunogenicity of Live Attenuated Varicella Vaccines for Healthy Children Completed NCT02981836 Phase 3
42 Safety Study of Menactra® (Meningococcal [Groups A, C, Y and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) When Administered With Other Pediatric Vaccines to Healthy Toddlers Completed NCT00483574 Phase 3
43 An Open, Randomised, Comparative, Multicentre Study of the Immunogenicity and Safety of M-M-R™II Manufactured With Recombinant Human Albumin (rHA) and VARIVAX® When Administered Concomitantly by Intramuscular (IM) Route or Subcutaneous (SC) Route at Two Separate Injection Sites in Healthy Subjects 12 to 18 Months of Age Completed NCT00432523 Phase 3
44 A Phase III Clinical Trial to Study the Safety, Tolerability, and Immunogenicity of ZOSTAVAX(R) in Healthy Adults in Taiwan Completed NCT00444860 Phase 3
45 An Immunogenicity, Safety, and Non-Interference Evaluation of Pediatric Vaccines Administered Concomitantly With Menactra® (Meningococcal [Groups A, C, Y and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) to Healthy Toddlers Completed NCT00422292 Phase 3
46 An Open-Label, Multicenter, Single-arm Study to Evaluate the Immunogenicity of VARIVAX™ in Healthy Russian Individuals 12 Months of Age and Older Completed NCT03843632 Phase 3
47 Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136 Completed NCT00751348 Phase 3
48 A Phase III Double Blind, Randomized, Multicenter, Controlled Study to Evaluate the Immunogenicity, Safety, and Tolerability of VARIVAX™ New Seed Process (NSP) Administered Concomitantly With M-M-R™ II Completed NCT02062502 Phase 3
49 Evaluation of Safety,Tolerability and Immunogenicity of Vaccination With VARIVAX (V210)in Healthy Indian Children Completed NCT00496327 Phase 3
50 An Open, Randomised, Comparative, Multicentre Study of the Immunogenicity and Safety of Concomitant Versus Separate Administration of a Combined Measles, Mumps, Rubella and Varicella Live Vaccine (ProQuad®) and a Booster Dose of Infanrix® Hexa in Healthy Children 12 to 23 Months of Age Completed NCT00432042 Phase 3

Search NIH Clinical Center for Chickenpox

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Acyclovir
Acyclovir Sodium

Cochrane evidence based reviews: chickenpox

Genetic Tests for Chickenpox

Anatomical Context for Chickenpox

Organs/tissues related to Chickenpox:

FMA: Skin
MalaCards : Skin, Brain, Bone Marrow, T Cells, Liver, Bone, Kidney

Publications for Chickenpox

Articles related to Chickenpox:

(show top 50) (show all 16901)
# Title Authors PMID Year
1
Activation of Interferon-Stimulated Genes following Varicella-Zoster Virus Infection in a Human iPSC-Derived Neuronal In Vitro Model Depends on Exogenous Interferon-α. 62 41
36423126 2022
2
Long-term vaccine efficacy of a 2-dose varicella vaccine in China from 2011 to 2021: A retrospective observational study. 62 41
36424959 2022
3
A prospective multicenter study on varicella-zoster virus infection in children with acute lymphoblastic leukemia. 62 41
36439222 2022
4
[Adenosine deaminase deficiency associated severe combined immunodeficiency with disseminated varicella infection after vaccination: a case report]. 53 62
19099832 2008
5
[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]. 53 62
12604384 2003
6
New variant of varicella-zoster virus. 53 62
12498673 2002
7
Expression of the simian varicella virus glycoprotein E. 53 62
11551643 2001
8
Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants. 53 62
10027650 1999
9
Identification of immunodominant regions and linear B cell epitopes of the gE envelope protein of varicella-zoster virus. 53 62
8553555 1995
10
Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine. 53 62
7486953 1995
11
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine. 53 62
8045919 1994
12
Susceptibility of Oka varicella vaccine strain to antiviral drugs. 53 62
8310756 1993
13
Structured Imaging Approach for Viral Encephalitis. 62
36404046 2023
14
Viral infections in pediatric brain tumor patients treated with targeted therapies. 62
36308741 2023
15
Humanized Severe Combined Immunodeficient (SCID) Mouse Models for Varicella-Zoster Virus Pathogenesis. 62
35292858 2023
16
Common Features Between Stroke Following Varicella in Children and Stroke Following Herpes Zoster in Adults : Varicella-Zoster Virus in Trigeminal Ganglion. 62
34224015 2023
17
A Guide to Preclinical Models of Zoster-Associated Pain and Postherpetic Neuralgia. 62
34524508 2023
18
Simian Varicella Virus: Molecular Virology and Mechanisms of Pathogenesis. 62
34669041 2023
19
Modulation of Host Cell Signaling Pathways by Varicella-Zoster Virus. 62
35624345 2023
20
Modulation of Apoptosis and Cell Death Pathways by Varicella-Zoster Virus. 62
35624346 2023
21
Varicella-Zoster Virus-Genetics, Molecular Evolution and Recombination. 62
34374828 2023
22
Modulation of MHC and MHC-Like Molecules by Varicella Zoster Virus. 62
35332385 2023
23
Varicella Zoster Virus Neuronal Latency and Reactivation Modeled in Vitro. 62
34904194 2023
24
Immune Responses to Varicella-Zoster Virus Vaccines. 62
35102438 2023
25
Low-dose acyclovir for prophylaxis of varicella-zoster virus reactivation after hematopoietic stem cell transplantation in children. 62
36151963 2022
26
Evaluation of Viral and Bacterial Pathogens in the Central Nervous System Infections with Multiplex PCR. 62
36474384 2022
27
Global varicella vaccination programs. 62
36457198 2022
28
Post-exposure prophylaxis to prevent varicella in immunocompromised children. 62
36120112 2022
29
Seroprevalence of VZV IgG antibody in kidney transplant recipients: A systematic and meta-analysis review. 62
36341911 2022
30
Varicella Vaccine: a Molecular Variant That May Contribute to Attenuation. 62
36468883 2022
31
[An inactive vaccine for primary immunization to chickenpox]. 62
36282185 2022
32
Estimating vaccination coverage for routinely recommended vaccines among children aged 24 months and adolescents aged 13 through 17 years using data from immunization information systems in the United States. 62
36357292 2022
33
Epidemiology of Varicella Zoster Virus and Herpes Zoster Virus in Gulf Cooperation Council Countries: A Review of the Literature. 62
36460839 2022
34
A case report of monkeypox as a result of conflict in the context of a measles campaign. 62
36133748 2022
35
Varicella Vaccine-Induced Infantile Zoster-Like Skin Rash. 62
36027973 2022
36
Comprehensive Investigations Relationship Between Viral Infections and Multiple Sclerosis Pathogenesis. 62
36459252 2022
37
Effect of FcRn antagonism on protective antibodies and to vaccines in IgG-mediated autoimmune diseases pemphigus and generalised myasthenia gravis. 62
36036539 2022
38
Herpes zoster: A primary care approach to diagnosis and treatment. 62
36346926 2022
39
Implementation of EACS vaccination recommendations among people living with HIV. 62
35522383 2022
40
Performance evaluation of the Viasure PCR assay for the diagnosis of monkeypox: A multicentre study. 62
36473345 2022
41
Evaluation of the seroprevalence of measles, rubella, mumps, and varicella and the requirement for additional vaccination based on the JSIPC guidelines among emergency medical technicians at eight fire stations in Narita, Japan: a project review. 62
34756159 2022
42
Evaluation of vaccination status of health care workers for recommended vaccines and their acceptance of SARS-CoV-2 vaccines. 62
35714279 2022
43
Clinical efficacy and effectiveness of alternative varicella vaccination strategies: An overview of reviews. 62
36378552 2022
44
Viral meningitis in Sudanese children: Differentiation, etiology and review of literature. 62
36401437 2022
45
Medical screening tests and vaccination among hospital-based physicians in Israel. 62
36357854 2022
46
First reports of monkeypox and varicella-zoster virus coinfection in the global human monkeypox outbreak in 2022. 62
36450328 2022
47
Characterization of the Cytopathic Effects of Monkeypox Virus Isolated from Clinical Specimens and Differentiation from Common Viral Exanthems. 62
36445152 2022
48
Fatal Pneumonia due to Disseminated Infection by Reactivated Varicella Zoster Virus in a Patient with Interstitial Lung Disease Associated with Rheumatoid Arthritis. 62
35718578 2022
49
Varicella Zoster Virus and Acute Retinal Necrosis. 62
36269803 2022
50
Epidemiology and characteristics of common forms of anterior uveitis at initial presentation in a tertiary facility in Japan. 62
36346554 2022

Variations for Chickenpox

Expression for Chickenpox

Search GEO for disease gene expression data for Chickenpox.

Pathways for Chickenpox

Pathways related to Chickenpox according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 CCR6 CD19 CD27 CD4 CD8A CRP
2
Show member pathways
13.68 TNF IL6 IL4 IL2 IL10 IFNG
3
Show member pathways
13.58 TNF IL6 IL4 IL2 IL10 IFNG
4
Show member pathways
13.45 CCR6 CD27 CD4 IL10 IL2 IL4
5
Show member pathways
13.36 CD27 CD4 IFNA1 IFNB1 IFNG IL10
6
Show member pathways
13.34 CCR6 CD27 CD4 IL10 IL2 IL4
7
Show member pathways
12.99 IL6 IL4 IL2 IFNB1 IFNA1 CD19
8
Show member pathways
12.86 TNF IL6 IL2 IFNB1 IFNA1
9
Show member pathways
12.69 TNF IL6 IL4 IL2 IL10 IFNG
10
Show member pathways
12.66 TNF IL6 IL2 IL10 IFNG CD4
11 12.59 TNF IL4 IL2 IL10 IFNG IFNA1
12
Show member pathways
12.53 TNF IL6 IFNB1 IFNA1
13
Show member pathways
12.47 TNF IL6 IL4 IFNG IFNB1
14
Show member pathways
12.24 TNF IL4 IL2 IFNG
15
Show member pathways
12.19 TNF IL4 IL2 IL10 IFNG IFNB1
16 12.18 IFNG IL10 IL4 IL6 TNF
17 12.09 TNF IL6 IL4 IL2 IFNG
18
Show member pathways
12.07 CD4 CD8A IFNG IL2 IL4
19 12.02 TNF IL6 IL4 IL10
20 11.97 TNF IL4 IL2 IL10 IFNG
21
Show member pathways
11.97 CD4 IFNG IL10 IL2 IL6 TNF
22
Show member pathways
11.93 IL6 IL4 IFNG CD4
23 11.93 IL6 IFNG IFNB1 IFNA1
24 11.85 IL6 IL4 IL2 IFNG
25 11.84 IL6 IL2 IL10 IFNG CD4
26 11.83 CCR6 CD4 CD8A IFNG IL10 IL2
27
Show member pathways
11.82 IL6 IFNB1 CRP CD8A CD4 ACE2
28
Show member pathways
11.81 TNF IFNG IFNB1
29
Show member pathways
11.79 TNF IL4 IL2 IFNG
30 11.79 IL6 IL4 IL2 IFNG CD4
31 11.78 TNF IL6 IFNB1
32 11.78 IL6 IL4 IL2 IL10 IFNG
33
Show member pathways
11.76 IFNG IL2 IL6 TNF
34 11.71 TNF IL6 IL4 IL2 IL10 IFNG
35 11.7 TNF IL6 IL4
36 11.69 IL10 IL6 TNF
37 11.69 IL10 IL6 TNF
38
Show member pathways
11.68 IFNG IL10 IL2 IL4 IL6 TNF
39 11.67 TNF IL6 IL4 IL2 IL10 IFNG
40 11.65 TNF IL10 IFNB1 ACE2
41 11.63 IL6 IL2 IFNG
42 11.6 TNF IL6 IFNG
43 11.6 TNF IL4 IL2 IL10 IFNG CD4
44 11.57 IL4 IL2 IL10 IFNG CD4
45 11.56 TNF IL6 IL10
46 11.54 IFNG IL6 TNF
47 11.52 TNF IL6 IFNB1
48
Show member pathways
11.47 TNF IL2 IL10 IFNG
50 11.42 TNF IL6 IL10

GO Terms for Chickenpox

Cellular components related to Chickenpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.2 TNF IL6 IL4 IL2 IL10 IFNG
2 external side of plasma membrane GO:0009897 9.8 ADA CCR6 CD19 CD27 CD4 CD8A
3 extracellular region GO:0005576 9.74 TNF IL6 IL4 IL2 IL10 IFNG

Biological processes related to Chickenpox according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 10.29 CD19 CD4 CD8A IFNA1 IFNB1 IFNG
2 negative regulation of inflammatory response GO:0050728 10.22 IL4 IL2 IL10 ADA
3 B cell differentiation GO:0030183 10.16 IL4 IL10 IFNB1 IFNA1
4 calcium-mediated signaling GO:0019722 10.15 TNF CD4 CCR6 ADA
5 cellular response to virus GO:0098586 10.14 IFNA1 IFNB1 IFNG IL6
6 negative regulation of apoptotic process GO:0043066 10.1 ADA ALB CD27 IL10 IL2 IL4
7 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.09 TNF IL6 IL10
8 liver regeneration GO:0097421 10.08 IL10 IL6 TNF
9 positive regulation of immunoglobulin production GO:0002639 10.05 IL6 IL2 IL10
10 microglial cell activation GO:0001774 10.04 IFNG IL4 TNF
11 T cell activation GO:0042110 10.03 IL4 CD8A CD4 ADA
12 B cell proliferation GO:0042100 10.01 ADA IFNA1 IFNB1 IL10
13 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.97 IFNG IFNB1 IFNA1
14 positive regulation of mononuclear cell migration GO:0071677 9.93 TNF IL4
15 negative regulation of cytokine production involved in immune response GO:0002719 9.93 TNF IL10
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.93 IL4 IL10 IFNG
17 regulation of isotype switching GO:0045191 9.91 IL4 IL10
18 positive regulation of plasma cell differentiation GO:1900100 9.9 IL2 IL10
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.89 TNF IFNG
20 positive regulation of nitrogen compound metabolic process GO:0051173 9.88 TNF IFNG
21 negative regulation of lipid storage GO:0010888 9.85 TNF IL6 CRP
22 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 TNF IL6 IL4 IL2 IFNG
23 positive regulation of vitamin D biosynthetic process GO:0060557 9.83 TNF IFNG
24 chronic inflammatory response to antigenic stimulus GO:0002439 9.81 TNF IL10
25 positive regulation of T cell differentiation GO:0045582 9.8 IL4 IL2 CD27 ADA
26 immune response GO:0006955 9.8 CCR6 CD4 CD8A IFNG IL10 IL2
27 humoral immune response GO:0006959 9.4 TNF IL6 IFNG IFNB1 IFNA1 CCR6

Molecular functions related to Chickenpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.53 TNF IL6 IL4 IL2 IL10 IFNG
2 cytokine receptor binding GO:0005126 9.26 IL4 IFNB1 IFNA1

Sources for Chickenpox

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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