Chickenpox disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHC001 MIFTS: 60	Chickenpox Categories: Immune diseases, Infectious diseases, Reproductive diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Chickenpox

MalaCards integrated aliases for Chickenpox:

Name: Chickenpox ¹¹ ⁷⁵ ⁴¹ ² ⁴³ ¹⁴ ⁶³ ¹⁶ ⁷¹ ³³

Varicella ¹¹ ⁵³ ¹⁴ ³³

Varicella Nos ³³

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases Immune diseases Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Certain infectious and parasitic diseases

Viral infections characterized by skin and mucous membrane lesions

Varicella [chickenpox]

Varicella with other complications

Varicella without complication

ICD11: ³³

Certain infectious or parasitic diseases

Viral infections characterised by skin or mucous membrane lesions

Varicella zoster virus infections

Varicella

Varicella with other specified complication

Varicella without complication

External Ids:

Disease Ontology ¹¹ DOID:8659

ICD9CM ³⁴ 052

MeSH ⁴³ D002644

NCIt ⁴⁹ C97132

SNOMED-CT ⁶⁸ 186508005

ICD10 ³¹ B01 B01.8 B01.9

EFO ¹⁶ EFO_0007204

ICD11 ³³ 1667539108 1805574500 1805574500/other

UMLS ⁷¹ C0008049

Sources

Summaries for Chickenpox

MedlinePlus: ⁴¹ Chickenpox is an infection caused by the varicella-zoster virus. Most cases are in children under age 15, but older children and adults can get it. It spreads very easily from one person to another. The classic symptom of chickenpox is an uncomfortable, itchy rash. The rash turns into fluid-filled blisters and eventually into scabs. It usually shows up on the face, chest, and back and then spreads to the rest of the body. Other symptoms include: Fever Headache Tiredness Loss of appetite Chickenpox is usually mild and lasts 5 to 10 days. Calamine lotions and oatmeal baths can help with itching. Acetaminophen can treat the fever. Do not use aspirin for chickenpox; that combination can cause Reye syndrome. Chickenpox can sometimes cause serious problems. Adults, babies, teenagers, pregnant women, and those with weak immune systems tend to get sicker from it. They may need to take antiviral medicines. Once you catch chickenpox, the virus usually stays in your body. You probably will not get chickenpox again, but the virus can cause shingles in adults. A chickenpox vaccine can help prevent most cases of chickenpox, or make it less severe if you do get it. Centers for Disease Control and Prevention

MalaCards based summary: Chickenpox, also known as varicella, is related to herpes zoster and human cytomegalovirus infection, and has symptoms including fever, anorexia and myalgia. An important gene associated with Chickenpox is GYPC (Glycophorin C (Gerbich Blood Group)), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Ethanol and Aluminum hydroxide have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and bone marrow, and related phenotypes are homeostasis/metabolism and normal

PubMed Health : ⁶³ Chickenpox: Chickenpox is a highly contagious viral infection which mainly affects children. Typical symptoms include a very itchy skin rash with red blisters and a mild fever. Because most children are now vaccinated, chickenpox (also referred to as varicella) is much less common than it was in the past. If someone comes down with chickenpox, they are contagious after just one or two days, which is before they have a visible rash. But taking precautions and improving hygiene can help to avoid infecting others. Although chickenpox is unpleasant, it rarely has any serious consequences in children who are otherwise healthy. But it may become more severe in newborns and adults, as well as people who have a weakened immune system.

CDC: ² Chickenpox is a highly contagious disease caused by the varicella-zoster virus (VZV). It can cause an itchy, blister-like rash. The rash first appears on the chest, back, and face, and then spreads over the entire body, causing between 250 and 500 itchy blisters. Chickenpox can be serious, especially in babies, adolescents, adults, pregnant women, and people with a weakened immune system. The best way to prevent chickenpox is to get the chickenpox vaccine.

Disease Ontology: ¹¹ A viral infectious disease that results in infection located in skin, has material basis in Human herpesvirus 3, which is transmitted by direct contact with secretions from the rash, or transmitted by droplet spread of respiratory secretions. The infection has symptom anorexia, has symptom myalgia, has symptom nausea, has symptom fever, has symptom headache, has symptom sore throat, and has symptom blisters.

Wikipedia: ⁷⁵ Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with... more...

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Related Diseases for Chickenpox

Diseases related to Chickenpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1628)

#	Related Disease	Score	Top Affiliating Genes
1	herpes zoster	32.6	IL2 IL10 IFNG IFNA1 GYPC CD8A
2	human cytomegalovirus infection	31.5	TNF IL6 IL10 IFNB1 GYPC CD8A
3	measles	31.3	IL6 IL2 IFNB1 IFNA1
4	keratitis, hereditary	31.1	TNF IL6 IL10 CD8A CD4 CCR6
5	smallpox	31.0	TNF IL4 IL2 IFNG
6	vaccinia	30.9	TNF IL6 IL2 IFNB1 IFNA1
7	graft-versus-host disease	30.9	TNF IL2 IL10 IFNG
8	radiculopathy	30.9	IL6 IL10 IFNA1 CRP
9	vasculitis	30.9	TNF IL6 IL10 CRP
10	mumps	30.9	TNF IL6 IL2 IL10 IFNG IFNB1
11	disseminated intravascular coagulation	30.8	TNF IL6 IL10 CRP
12	parotitis	30.8	CRP CD8A CD4 ALB
13	encephalitis	30.8	TNF IL6 IL10 IFNB1 IFNA1
14	acute retinal necrosis syndrome	30.7	TNF IL6 IL10 GYPC CD8A CD4
15	granulomatous angiitis	30.7	CRP CD8A CD4
16	headache	30.7	TNF IL2 ALB
17	inappropriate adh syndrome	30.7	IL6 CRP ALB
18	purpura	30.7	TNF IL6 IL4 IL2 IL10 IFNG
19	necrotizing fasciitis	30.7	TNF IL6 CRP ALB
20	pancreatitis	30.7	TNF IL6 IL10 CRP ALB
21	fasciitis	30.6	TNF IL6 IL2 IFNG IFNA1
22	rubella	30.6	TNF IL6 IL4 IL2 IL10 IFNG
23	retinal vasculitis	30.6	TNF IFNB1 CD4 CCR6
24	bell's palsy	30.6	TNF IL6 CRP CD8A CD4 ALB
25	adult syndrome	30.6	TNF IL6 CRP
26	cranial nerve palsy	30.6	TNF CRP CD4 ALB
27	bowel dysfunction	30.6	TNF IL6 IL10 CRP ALB
28	facial paralysis	30.6	TNF IL6 CRP CD8A CD4 ALB
29	polyarteritis nodosa	30.6	TNF IL6 CRP
30	pars planitis	30.6	IL2 CD27 CCR6
31	inflammatory bowel disease 1	30.5	TNF IL6 IL10 CCR6
32	paine syndrome	30.5	TNF IL6 IL10
33	acute disseminated encephalomyelitis	30.5	IL6 IFNB1 CRP CD8A CD4 CCR6
34	monkeypox	30.5	IFNA1 CD8A CD4
35	pleural empyema	30.5	IL6 CRP CD4 ALB ADA
36	scarlet fever	30.5	TNF IL6 CRP CD4 ALB
37	pericarditis	30.5	TNF IL6 IFNG CRP ADA ACE2
38	adult respiratory distress syndrome	30.5	TNF IL6 IL10 CRP CCR6 ACE2
39	myelitis	30.5	TNF IL6 IL10 IFNB1 CD27 CCR6
40	genital herpes	30.5	TNF IL2 IFNB1 IFNA1 GYPC CD8A
41	optic papillitis	30.5	TNF CRP CD4
42	pyoderma	30.5	TNF CRP CCR6
43	optic neuritis	30.5	TNF IL6 IL10
44	paralytic ileus	30.5	IL6 CRP ALB
45	herpes simplex	30.4	IFNB1 IFNA1 GYPC CD8A
46	spinal cord disease	30.4	TNF IL6 IL10 IFNB1 CD8A CD4
47	leukemia, acute lymphoblastic	30.4	IL2 CD8A CD4 CD19 CCR6 ADA
48	spondyloarthropathy 1	30.4	TNF IL6 IL10 CRP CD8A CD4
49	herpes simplex virus keratitis	30.4	IFNB1 GYPC CD8A CD4
50	ileus	30.4	TNF IL6 IL10 IFNG CRP

Graphical network of the top 20 diseases related to Chickenpox:

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Symptoms & Phenotypes for Chickenpox

Symptoms:

¹¹

• fever
• anorexia
• myalgia
• headache

• nausea
• sore throat
• blisters

UMLS symptoms related to Chickenpox:

fever; pruritus; exanthema

MGI Mouse Phenotypes related to Chickenpox:

⁴⁵ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.31	ACE2 ADA ALB CCR6 CD19 CD4
2	normal	MP:0002873	10.19	ADA ALB CCR6 CD19 CD8A IFNA1
3	cellular	MP:0005384	10.17	ACE2 ADA ALB CD19 CD27 CD4
4	neoplasm	MP:0002006	10.11	ALB CD19 IFNB1 IFNG IL10 IL2
5	liver/biliary system	MP:0005370	10.11	ADA ALB CD19 IFNG IL10 IL2
6	digestive/alimentary	MP:0005381	10.11	ACE2 ADA ALB CD19 CD4 IFNG
7	immune system	MP:0005387	10.11	ACE2 ADA ALB CCR6 CD19 CD27
8	endocrine/exocrine gland	MP:0005379	10.1	ADA ALB CD4 CD8A IFNG IL10
9	no phenotypic analysis	MP:0003012	10.02	CD4 IFNB1 IFNG IL10 IL2 IL4
10	cardiovascular system	MP:0005385	10	ACE2 ADA ALB CCR6 CD19 CRP
11	respiratory system	MP:0005388	9.61	ACE2 ADA IFNA1 IFNG IL10 IL2
12	hematopoietic system	MP:0005397	9.55	ACE2 ADA CCR6 CD19 CD27 CD4

Sources

Drugs & Therapeutics for Chickenpox

PubMed Health treatment related to Chickenpox: ⁶³

The treatment usually focuses on relieving the symptoms of chickenpox . In more severe cases, or if there is a greater risk of complications, antiviral drugs can be used to fight off the virus. Lotions, gels and powders are often applied in order to relieve itching and dry out the blisters . Most of them contain tanins, zinc , menthol or polidocanol . Sometimes oral medication like antihistamines is also recommended to stop the itching. But there is no good-quality scientific research on how effective they are. Symptoms like fever or aching muscles can be relieved using medicine that contains acetaminophen (paracetamol). The painkiller ibuprofen is not suitable for children with chickenpox . Children and teenagers should only take acetylsalicylic acid (ASA, the drug in medicines like Aspirin ) if it has been prescribed by a doctor, and only as a last resort. This is because it can cause a rare but dangerous side effect called Reye’s syndrome in children and teenagers.

Drugs for Chickenpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ethanol

Approved

Phase 4

64-17-5

702

Aluminum hydroxide

Approved, Investigational

Phase 4

21645-51-2

Budesonide

Approved

Phase 4

51333-22-3

5281004 40000 63006

Carbamide peroxide

Approved

Phase 4

124-43-6

Arginine

Approved, Investigational, Nutraceutical

Phase 4

74-79-3

6322

Glutamic acid

Approved, Nutraceutical

Phase 4

56-86-0

33032

Antiviral Agents

Phase 4

Anti-Infective Agents

Phase 4

Pharmaceutical Solutions

Phase 4

Bronchodilator Agents

Phase 4

Anti-Asthmatic Agents

Phase 4

Hormones

Phase 4

Hormone Antagonists

Phase 4

glucocorticoids

Phase 4

Respiratory System Agents

Phase 4

Anti-Inflammatory Agents

Phase 4

Immunoglobulins

Phase 4

Antibodies

Phase 4

Potassium phosphate

Phase 4

Methylene blue

Approved, Investigational

Phase 3

61-73-4

6099

Altretamine

Approved

Phase 3

645-05-6

2123

Famciclovir

Approved, Investigational

Phase 3

104227-87-4

3324

Acyclovir

Approved

Phase 3

59277-89-3

2022

Sorbitol

Approved, Investigational

Phase 3

69-65-8, 50-70-4

453 6251 5780

Sorivudine

Investigational

Phase 3

77181-69-2

5-propynylarabinofuranosyluracil

Phase 3

Somatomedin B

Phase 3

Hemagglutinins

Phase 3

Taxane

Phase 3

108169

Acetic acid

Approved

Phase 2

64-19-7

176

Acalabrutinib

Approved, Investigational

Phase 2

1420477-60-6

71226663 71226662

D-Tyrosine

Approved, Experimental, Investigational, Nutraceutical

Phase 2

133585-56-5, 60-18-4, 556-02-5

1153 6057

Zuretinol acetate

Investigational

Phase 2

127-47-9, 29584-22-3

10245972

Immunologic Factors

Phase 2

Heptavalent Pneumococcal Conjugate Vaccine

Phase 2

Cholecalciferol

Approved, Nutraceutical, Vet_approved

Phase 1

67-97-0, 1406-16-2

5280795 10883523

Calcifediol

Approved, Nutraceutical

Phase 1

19356-17-3

5283731

Vitamins

Phase 1

Calciferol

Phase 1

Hydroxycholecalciferols

Phase 1

Antibodies, Monoclonal

Phase 1

Valaciclovir

Approved, Investigational

124832-27-5, 124832-26-4

60773 135398742

Ascorbic acid

Approved, Nutraceutical

50-81-7

54676860 54670067 5785

Immunoglobulin G

Immunoglobulins, Intravenous

gamma-Globulins

Rho(D) Immune Globulin

Antioxidants

Anti-Bacterial Agents

Antibiotics, Antitubercular

Interventional clinical trials:

(show top 50) (show all 158)

#	Name	Status	NCT ID	Phase	Drugs
1	A Cross-over, Open-label, Single-group Study to Evaluate the Safety and Immunogenicity of Live Attenuated Varicella Vaccine Skyvaricella Injection (Inj.) Developed by SK Bioscience (Company Limited) Co., Ltd of South Korea in Healthy Volunteer Vietnamese Children From 12 Months to 12 Years Old	Unknown status	NCT04384016	Phase 4
2	A Study of Immune Persistence After Inoculated With One-dose Freeze-dried Live Attenuated Varicella Vaccine in Children Aged 1-6 Years	Unknown status	NCT01982409	Phase 4
3	Study on Effectiveness of 2-dose Live Attenuated Varicella Vaccine	Unknown status	NCT02146469	Phase 4
4	Phase 4 Study of Live Attenuated Varicella Vaccine After the 2 Doses Vaccination	Unknown status	NCT01866566	Phase 4
5	Safety and Immunogenicity of Measles Vaccine, Varicella Vaccine and Hepatitis-A Vaccine in HIV-exposed and HIV-unexposed South African Children	Unknown status	NCT03330171	Phase 4
6	Phase 4 Study of the Varicella Vaccine After the 2nd Dose Vaccination	Unknown status	NCT01830283	Phase 4
7	A Pilot Study to Characterize the Immune Response Induced by a Commercial Varicella Zoster Virus Vaccine in Healthy Adult Females in Nairobi, Kenya.	Unknown status	NCT02514018	Phase 4
8	Safety and Immunogenicity of Non-live, Recombinant Subunit Herpes Zoster Vaccine Before and After Lung Transplantation	Unknown status	NCT03493776	Phase 4
9	Evaluation of Safety and Immunogenicity Receiving Live Attenuated Vaccine Against Varicella Without Gelatin	Completed	NCT01684072	Phase 4
10	An Open, Multicenter Study of the Safety and Tolerability of VAQTA(TM) and ProQuad(TM) in Healthy Children 12 to 23 Months of Age	Completed	NCT00326183	Phase 4
11	A Study to Evaluate the Immunogenicity and Safety of 2 Doses of Live Attenuated Varicella Vaccine	Completed	NCT01817270	Phase 4
12	A Study to Evaluate the Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Live Attenuated JE Vaccine	Completed	NCT01815073	Phase 4
13	A Randomized, Controlled Clinical Trial to Evaluate the Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Inactivated Hepatitis A Vaccine	Completed	NCT05526820	Phase 4
14	Safety of a Second Dose of Biken's Varicella Vaccine Administered at 4 to 6 Years of Age in Healthy Children in Argentina	Completed	NCT00830648	Phase 4
15	Rates of Seroconversion Following Varicella Vaccination of Asthmatic Children Between the Ages of One and Eight Years Treated With Pulmicort Respules® Versus Non-Steroidal Conventional Asthma Therapy	Completed	NCT00641446	Phase 4	budesonide;varicella zoster virus
16	A Double-blind, Randomised, Controlled, Multi-centre Safety Study of a Refrigerator-stable Formulation of VARIVAX® in Healthy 12 to 15 Month-old Infants.	Completed	NCT00432731	Phase 4
17	T Cell Responses to Varicella Zoster Virus After Vaccination and Viral Escape	Completed	NCT01911065	Phase 4
18	Blinded, Randomised Study to Assess the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Live Attenuated Measles-mumps-rubella-varicella Candidate Vaccine When Given to Healthy Children in Their Second Year of Life	Completed	NCT00126997	Phase 4
19	The Immunogenicity of Varicella-zoster Virus Vaccine in HIV-infected Children	Completed	NCT01138215	Phase 4
20	A Study to Evaluate the Immunogenicity and Safety of 2 Doses of Live Attenuated Varicella Vaccine	Completed	NCT02173899	Phase 4
21	Live Attenuated Varicella Vaccine: A New Effective Adjuvant Weapon in the Battlefield Against Severe Resistant Psoriasis, a Randomized Controlled Trial	Completed	NCT01356004	Phase 4	live attenuated chicken pox vaccine;saline, efficacy
22	Palatability Testing of a New Paediatric Formulation of Valacyclovir for the Prophylaxis and Treatment of VZV and HSV Infections in Children	Completed	NCT01682109	Phase 4	Valacyclovir
23	A Clinical Trial to Evaluate Protective Effect, Safety and Immunogenicity of Live Attenuated Varicella Vaccine in Children Aged 1-12 Years	Recruiting	NCT05470855	Phase 4
24	A Randomized, Blind, Controlled Clinical Trial to Evaluate Safety and Immunogenicity of Live Attenuated Varicella Vaccine After a Two-dose Vaccination Course in Healthy Population Aged ≥13 Years Old	Recruiting	NCT05015686	Phase 4
25	An Open Clinical Trial to Evaluate the Immunity Persistence of Live Attenuated Varicella Vaccine at 5 and 8 Years After Primary Immunization With Live Attenuated Varicella Vaccine	Not yet recruiting	NCT05095701	Phase 4
26	An Open Clinical Trial to Evaluate Immunogenicity,Safety and Protective Effect of Live Attenuated Varicella Vaccine and a Clinical Trial on Antibody Level and Etiology of Varicella Zoster Virus in Zhejiang Province	Not yet recruiting	NCT05460429	Phase 4
27	VZV-specific Tissue Resident Memory T-cells After Shingrix Vaccination	Not yet recruiting	NCT04403139	Phase 4	Shingrix
28	A Double Blind Placebo-controlled Randomized Study of Varicella Zoster Vaccine in Patients With Moderate-to-severe Plaque Psoriasis Who Are Candidates for Biologic Therapy	Terminated	NCT02408159	Phase 4	Varicella Zoster Vaccine;Placebo
29	Persistence of Varicella Immunity in Hospital Employees Receiving Varicella Vaccine	Withdrawn	NCT02026089	Phase 4
30	Serological Evaluation of Chickenpox (Varicella) and Hepatitis A Vaccines Using Disposable Needle-Free Syringe Jet Injector (DSJI) Delivery	Unknown status	NCT00926419	Phase 2, Phase 3
31	A Comparative Study of Tzanck Smear With Methylene Blue Versus Giemsa Stain to Diagnose Herpes Simplex, Herpes Zoster and Varicella Zoster Skin Infections	Unknown status	NCT03178747	Phase 3
32	Clinical Evaluation of Valaciclovir Hydrochloride: 256U87 in Patients With Chickenpox - Open Uncontrolled Study.	Completed	NCT00169416	Phase 3	valaciclovir HCl granules
33	Safety and Immunogenicity Study of 2 Formulations of GSK Biologicals' Varicella Vaccines Given as a 2-dose Course in the Second Year of Life.	Completed	NCT02570126	Phase 3
34	Pharmacokinetics and Safety of Famciclovir Oral Pediatric Formulation in Children 1-12 Years of Age With Varicella Zoster Infection	Completed	NCT00098046	Phase 3	famciclovir
35	Open-Label BV-araU Treatment of Pediatric HIV-Infected Patients With Cutaneous, Visceral, or Ocular Varicella-Zoster Viral Disease Who Have Failed or Are Intolerant of Standard Therapy	Completed	NCT00002358	Phase 3	Sorivudine
36	Study in Healthy Children (<2 Years) to Evaluate the Safety and Efficacy of GSK Biologicals' Live Attenuated Varicella Vaccine (VarilrixTM) and of GSK Biologicals' Combined Measles-Mumps-Rubella-Varicella Vaccine	Completed	NCT00226499	Phase 3
37	A Double-Blind, Multicenter Study Comparing Oral 882C87 With Oral Acyclovir for Treatment of Localized Herpes Zoster in Immunocompromised Patients	Completed	NCT00002315	Phase 3	Netivudine;Acyclovir
38	Safety, Tolerability, and Immunogenicity of VARIVAX (2007 Commercial VZV Bulk Process) Administered Concomitantly With M-M-R II in Healthy Children 12-to-23 Months of Age	Completed	NCT00822237	Phase 3
39	Follow-up to Evaluate the the Immunogenicity & Safety of GSK Biologicals' MMRV Vaccine Given as a Two-dose Schedule in the Second Year of Life, as Compared to Separate Administration of GSK Biologicals' Priorix® & Varilrix®.	Completed	NCT00406211	Phase 3
40	An Immunogenicity and Safety Evaluation of Two Doses of Menactra® (Meningococcal [Groups A, C, Y and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) Given to Healthy Subjects at 9 and 12 Months of Age	Completed	NCT00384397	Phase 3
41	A Blind, Randomized and Controlled Clinical Trial to Evaluate the Protective Effect, Safety and Immunogenicity of Live Attenuated Varicella Vaccines for Healthy Children	Completed	NCT02981836	Phase 3
42	Safety Study of Menactra® (Meningococcal [Groups A, C, Y and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) When Administered With Other Pediatric Vaccines to Healthy Toddlers	Completed	NCT00483574	Phase 3
43	An Open, Randomised, Comparative, Multicentre Study of the Immunogenicity and Safety of M-M-R™II Manufactured With Recombinant Human Albumin (rHA) and VARIVAX® When Administered Concomitantly by Intramuscular (IM) Route or Subcutaneous (SC) Route at Two Separate Injection Sites in Healthy Subjects 12 to 18 Months of Age	Completed	NCT00432523	Phase 3
44	A Phase III Clinical Trial to Study the Safety, Tolerability, and Immunogenicity of ZOSTAVAX(R) in Healthy Adults in Taiwan	Completed	NCT00444860	Phase 3
45	An Immunogenicity, Safety, and Non-Interference Evaluation of Pediatric Vaccines Administered Concomitantly With Menactra® (Meningococcal [Groups A, C, Y and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) to Healthy Toddlers	Completed	NCT00422292	Phase 3
46	An Open-Label, Multicenter, Single-arm Study to Evaluate the Immunogenicity of VARIVAX™ in Healthy Russian Individuals 12 Months of Age and Older	Completed	NCT03843632	Phase 3
47	Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136	Completed	NCT00751348	Phase 3
48	A Phase III Double Blind, Randomized, Multicenter, Controlled Study to Evaluate the Immunogenicity, Safety, and Tolerability of VARIVAX™ New Seed Process (NSP) Administered Concomitantly With M-M-R™ II	Completed	NCT02062502	Phase 3
49	Evaluation of Safety,Tolerability and Immunogenicity of Vaccination With VARIVAX (V210)in Healthy Indian Children	Completed	NCT00496327	Phase 3
50	An Open, Randomised, Comparative, Multicentre Study of the Immunogenicity and Safety of Concomitant Versus Separate Administration of a Combined Measles, Mumps, Rubella and Varicella Live Vaccine (ProQuad®) and a Booster Dose of Infanrix® Hexa in Healthy Children 12 to 23 Months of Age	Completed	NCT00432042	Phase 3

Search NIH Clinical Center for Chickenpox

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Acyclovir

Acyclovir Sodium

Cochrane evidence based reviews: chickenpox

Sources

Genetic Tests for Chickenpox

Sources

Anatomical Context for Chickenpox

Organs/tissues related to Chickenpox:

FMA: Skin

MalaCards : Skin, Brain, Bone Marrow, T Cells, Liver, Bone, Kidney

Sources

Publications for Chickenpox

Articles related to Chickenpox:

(show top 50) (show all 16901)

#	Title	Authors	PMID	Year
1	Activation of Interferon-Stimulated Genes following Varicella-Zoster Virus Infection in a Human iPSC-Derived Neuronal In Vitro Model Depends on Exogenous Interferon-α. ⁶² ⁴¹	Boeren M...Delputte P	36423126	2022
2	Long-term vaccine efficacy of a 2-dose varicella vaccine in China from 2011 to 2021: A retrospective observational study. ⁶² ⁴¹	Shu M...Pan X	36424959	2022
3	A prospective multicenter study on varicella-zoster virus infection in children with acute lymphoblastic leukemia. ⁶² ⁴¹	Xiao P...Hu S	36439222	2022
4	[Adenosine deaminase deficiency associated severe combined immunodeficiency with disseminated varicella infection after vaccination: a case report]. ⁵³ ⁶²	Zhang WX...Zhao W	19099832	2008
5	[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]. ⁵³ ⁶²	Morfin F...Thouvenot D	12604384	2003
6	New variant of varicella-zoster virus. ⁵³ ⁶²	Tipples GA...Grose C	12498673	2002
7	Expression of the simian varicella virus glycoprotein E. ⁵³ ⁶²	Gray WL...Soike KF	11551643	2001
8	Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants. ⁵³ ⁶²	Ida M...Shiraki K	10027650	1999
9	Identification of immunodominant regions and linear B cell epitopes of the gE envelope protein of varicella-zoster virus. ⁵³ ⁶²	Fowler WJ...Layton GT	8553555	1995
10	Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine. ⁵³ ⁶²	Kodama E...Shigeta S	7486953	1995
11	Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine. ⁵³ ⁶²	Keizer HJ...De Clercq E	8045919	1994
12	Susceptibility of Oka varicella vaccine strain to antiviral drugs. ⁵³ ⁶²	Shiraki K...Aiba N	8310756	1993
13	Structured Imaging Approach for Viral Encephalitis. ⁶²	Ramli NM...Bae YJ	36404046	2023
14	Viral infections in pediatric brain tumor patients treated with targeted therapies. ⁶²	Mayr L...Peyrl A	36308741	2023
15	Humanized Severe Combined Immunodeficient (SCID) Mouse Models for Varicella-Zoster Virus Pathogenesis. ⁶²	Lloyd MG...Moffat JF	35292858	2023
16	Common Features Between Stroke Following Varicella in Children and Stroke Following Herpes Zoster in Adults : Varicella-Zoster Virus in Trigeminal Ganglion. ⁶²	Grose C...Fullerton HJ	34224015	2023
17	A Guide to Preclinical Models of Zoster-Associated Pain and Postherpetic Neuralgia. ⁶²	Warner BE...Kinchington PR	34524508	2023
18	Simian Varicella Virus: Molecular Virology and Mechanisms of Pathogenesis. ⁶²	Jankeel A...Messaoudi I	34669041	2023
19	Modulation of Host Cell Signaling Pathways by Varicella-Zoster Virus. ⁶²	Sen N...Arvin AM	35624345	2023
20	Modulation of Apoptosis and Cell Death Pathways by Varicella-Zoster Virus. ⁶²	Steain M...Abendroth A	35624346	2023
21	Varicella-Zoster Virus-Genetics, Molecular Evolution and Recombination. ⁶²	Depledge DP...Breuer J	34374828	2023
22	Modulation of MHC and MHC-Like Molecules by Varicella Zoster Virus. ⁶²	Abendroth A...Slobedman B	35332385	2023
23	Varicella Zoster Virus Neuronal Latency and Reactivation Modeled in Vitro. ⁶²	Goldstein RS...Kinchington PR	34904194	2023
24	Immune Responses to Varicella-Zoster Virus Vaccines. ⁶²	Levin MJ...Weinberg A	35102438	2023
25	Low-dose acyclovir for prophylaxis of varicella-zoster virus reactivation after hematopoietic stem cell transplantation in children. ⁶²	Tatebe Y...Zamami Y	36151963	2022
26	Evaluation of Viral and Bacterial Pathogens in the Central Nervous System Infections with Multiplex PCR. ⁶²	Oner SZ...Caliskan A	36474384	2022
27	Global varicella vaccination programs. ⁶²	Lee YH...Kim YK	36457198	2022
28	Post-exposure prophylaxis to prevent varicella in immunocompromised children. ⁶²	Yamaguchi M...Ito Y	36120112	2022
29	Seroprevalence of VZV IgG antibody in kidney transplant recipients: A systematic and meta-analysis review. ⁶²	Alimohammadi M...Mousavi T	36341911	2022
30	Varicella Vaccine: a Molecular Variant That May Contribute to Attenuation. ⁶²	Gershon AA...Gershon MD	36468883	2022
31	[An inactive vaccine for primary immunization to chickenpox]. ⁶²	Rodriguez-Garcia J...Garcia Erce JA	36282185	2022
32	Estimating vaccination coverage for routinely recommended vaccines among children aged 24 months and adolescents aged 13 through 17 years using data from immunization information systems in the United States. ⁶²	Kirtland KA...Zell ER	36357292	2022
33	Epidemiology of Varicella Zoster Virus and Herpes Zoster Virus in Gulf Cooperation Council Countries: A Review of the Literature. ⁶²	Badur S...Guzman-Holst A	36460839	2022
34	A case report of monkeypox as a result of conflict in the context of a measles campaign. ⁶²	Jarman EL...Omam LA	36133748	2022
35	Varicella Vaccine-Induced Infantile Zoster-Like Skin Rash. ⁶²	Sugai T...Shimizu S	36027973	2022
36	Comprehensive Investigations Relationship Between Viral Infections and Multiple Sclerosis Pathogenesis. ⁶²	Sedighi S...Dadashpour M	36459252	2022
37	Effect of FcRn antagonism on protective antibodies and to vaccines in IgG-mediated autoimmune diseases pemphigus and generalised myasthenia gravis. ⁶²	Guptill JT...Winthrop KL	36036539	2022
38	Herpes zoster: A primary care approach to diagnosis and treatment. ⁶²	Kelley A	36346926	2022
39	Implementation of EACS vaccination recommendations among people living with HIV. ⁶²	Breitschwerdt S...Boesecke C	35522383	2022
40	Performance evaluation of the Viasure PCR assay for the diagnosis of monkeypox: A multicentre study. ⁶²	Tan NK...Pope CF	36473345	2022
41	Evaluation of the seroprevalence of measles, rubella, mumps, and varicella and the requirement for additional vaccination based on the JSIPC guidelines among emergency medical technicians at eight fire stations in Narita, Japan: a project review. ⁶²	Hase R...Mito H	34756159	2022
42	Evaluation of vaccination status of health care workers for recommended vaccines and their acceptance of SARS-CoV-2 vaccines. ⁶²	Oygar PD...Kara A	35714279	2022
43	Clinical efficacy and effectiveness of alternative varicella vaccination strategies: An overview of reviews. ⁶²	Ahern S...Ryan M	36378552	2022
44	Viral meningitis in Sudanese children: Differentiation, etiology and review of literature. ⁶²	Abdelrahim NA...Fadl-Elmula IM	36401437	2022
45	Medical screening tests and vaccination among hospital-based physicians in Israel. ⁶²	Eltalakat S...Treister-Goltzman Y	36357854	2022
46	First reports of monkeypox and varicella-zoster virus coinfection in the global human monkeypox outbreak in 2022. ⁶²	Martins-Filho PR...Dos Santos CA	36450328	2022
47	Characterization of the Cytopathic Effects of Monkeypox Virus Isolated from Clinical Specimens and Differentiation from Common Viral Exanthems. ⁶²	Ma A...Bradley BT	36445152	2022
48	Fatal Pneumonia due to Disseminated Infection by Reactivated Varicella Zoster Virus in a Patient with Interstitial Lung Disease Associated with Rheumatoid Arthritis. ⁶²	Urrutia Royo B...Robles-Perez A	35718578	2022
49	Varicella Zoster Virus and Acute Retinal Necrosis. ⁶²	Savastano A...Rizzo S	36269803	2022
50	Epidemiology and characteristics of common forms of anterior uveitis at initial presentation in a tertiary facility in Japan. ⁶²	Okazawa R...Takeuchi M	36346554	2022

Sources

Genes for Chickenpox

Genes related to Chickenpox (0 elite genes):

(show all 34)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	GYPC	Glycophorin C (Gerbich Blood Group)	Protein Coding	13.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8553555 11551643 12498673
2	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.74	DISEASES inferred ¹⁴ ¹⁴
3	CD4	CD4 Molecule	Protein Coding	7.72	DISEASES inferred ¹⁴
4	ADA	Adenosine Deaminase	Protein Coding	7.67	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19099832
5	CD8A	CD8a Molecule	Protein Coding	7.36	DISEASES inferred ¹⁴
6	CRP	C-Reactive Protein	Protein Coding	6.77	DISEASES inferred ¹⁴
7	RNU4ATAC	RNA, U4atac Small Nuclear	RNA Gene	6.74	DISEASES inferred ¹⁴ ¹⁴
8	TNF	Tumor Necrosis Factor	Protein Coding	6.64	DISEASES inferred ¹⁴
9	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	6.62	DISEASES inferred ¹⁴
10	IL6	Interleukin 6	Protein Coding	6.56	DISEASES inferred ¹⁴
11	IL2	Interleukin 2	Protein Coding	6.39	DISEASES inferred ¹⁴
12	IFNB1	Interferon Beta 1	Protein Coding	6.38	DISEASES inferred ¹⁴
13	DOCK8	Dedicator Of Cytokinesis 8	Protein Coding	6.3	DISEASES inferred ¹⁴
14	IFNA1	Interferon Alpha 1	Protein Coding	6.29	DISEASES inferred ¹⁴
15	CD19	CD19 Molecule	Protein Coding	6.28	DISEASES inferred ¹⁴
16	IL10	Interleukin 10	Protein Coding	6.26	DISEASES inferred ¹⁴
17	IFNG	Interferon Gamma	Protein Coding	6.26	DISEASES inferred ¹⁴
18	ALB	Albumin	Protein Coding	6.09	DISEASES inferred ¹⁴
19	CD27	CD27 Molecule	Protein Coding	5.98	DISEASES inferred ¹⁴
20	IL4	Interleukin 4	Protein Coding	5.9	DISEASES inferred ¹⁴
21	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	5.86	DISEASES inferred ¹⁴
22	POLR3C	RNA Polymerase III Subunit C	Protein Coding	5.85	DISEASES inferred ¹⁴
23	TLR3	Toll Like Receptor 3	Protein Coding	5.84	DISEASES inferred ¹⁴
24	IL1B	Interleukin 1 Beta	Protein Coding	5.84	DISEASES inferred ¹⁴
25	IL17A	Interleukin 17A	Protein Coding	5.83	DISEASES inferred ¹⁴
26	FCGR3A	Fc Gamma Receptor IIIa	Protein Coding	5.8	DISEASES inferred ¹⁴
27	CSF3	Colony Stimulating Factor 3	Protein Coding	5.79	DISEASES inferred ¹⁴
28	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	5.76	DISEASES inferred ¹⁴
29	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	5.74	DISEASES inferred ¹⁴
30	ACE	Angiotensin I Converting Enzyme	Protein Coding	5.74	DISEASES inferred ¹⁴
31	AQP4	Aquaporin 4	Protein Coding	5.74	DISEASES inferred ¹⁴
32	FCGR3B	Fc Gamma Receptor IIIb	Protein Coding	5.74	DISEASES inferred ¹⁴
33	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	5.7	DISEASES inferred ¹⁴
34	F2	Coagulation Factor II, Thrombin	Protein Coding	5.65	DISEASES inferred ¹⁴

Sources

Variations for Chickenpox

Sources

Expression for Chickenpox

Search GEO for disease gene expression data for Chickenpox.

Sources

Pathways for Chickenpox

Pathways related to Chickenpox according to GeneCards Suite gene sharing:

(show top 50) (show all 64)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14	CCR6 CD19 CD27 CD4 CD8A CRP
2	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.68	TNF IL6 IL4 IL2 IL10 IFNG
3	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.58	TNF IL6 IL4 IL2 IL10 IFNG
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.45	CCR6 CD27 CD4 IL10 IL2 IL4
5	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.36	CD27 CD4 IFNA1 IFNB1 IFNG IL10
6	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.34	CCR6 CD27 CD4 IL10 IL2 IL4
7	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.99	IL6 IL4 IL2 IFNB1 IFNA1 CD19
8	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.86	TNF IL6 IL2 IFNB1 IFNA1
9	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.69	TNF IL6 IL4 IL2 IL10 IFNG
10	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.66	TNF IL6 IL2 IL10 IFNG CD4
11	NF-kappaB Signaling ³	12.59	TNF IL4 IL2 IL10 IFNG IFNA1
12	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.53	TNF IL6 IFNB1 IFNA1
13	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.47	TNF IL6 IL4 IFNG IFNB1
14	Immune response CD16 signaling in NK cells ²² Show member pathways Immune response Role of DAP12 receptors in NK cells ²²	12.24	TNF IL4 IL2 IFNG
15	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.19	TNF IL4 IL2 IL10 IFNG IFNB1
16	Neuroinflammation and glutamatergic signaling ⁷⁴	12.18	IFNG IL10 IL4 IL6 TNF
17	Spinal cord injury ⁷⁴	12.09	TNF IL6 IL4 IL2 IFNG
18	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	12.07	CD4 CD8A IFNG IL2 IL4
19	Interleukin-4 and Interleukin-13 signaling ⁶⁶	12.02	TNF IL6 IL4 IL10
20	Allograft rejection ⁷⁴	11.97	TNF IL4 IL2 IL10 IFNG
21	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.97	CD4 IFNG IL10 IL2 IL6 TNF
22	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.93	IL6 IL4 IFNG CD4
23	Interferon Pathway ⁶⁴	11.93	IL6 IFNG IFNB1 IFNA1
24	Glucocorticoid receptor regulatory network ⁶¹	11.85	IL6 IL4 IL2 IFNG
25	Acute viral myocarditis ⁷⁴	11.84	IL6 IL2 IL10 IFNG CD4
26	Innate Lymphoid Cells Differentiation ⁶⁵	11.83	CCR6 CD4 CD8A IFNG IL10 IL2
27	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.82	IL6 IFNB1 CRP CD8A CD4 ACE2
28	Activation of NF-KappaB by PKR ⁶⁴ Show member pathways Canonical NF-kB pathway ⁷⁴ Cellular Transformation by HTLV1 ⁶⁴ Inhibition of PKR ⁶⁶ STING pathway in Kawasaki-like disease and COVID-19 ⁷⁴	11.81	TNF IFNG IFNB1
29	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.79	TNF IL4 IL2 IFNG
30	Th17 cell differentiation pathway ⁷⁴	11.79	IL6 IL4 IL2 IFNG CD4
31	Burn wound healing ⁷⁴	11.78	TNF IL6 IFNB1
32	AP-1 transcription factor network ⁶¹	11.78	IL6 IL4 IL2 IL10 IFNG
33	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.76	IFNG IL2 IL6 TNF
34	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.71	TNF IL6 IL4 IL2 IL10 IFNG
35	Lung fibrosis ⁷⁴	11.7	TNF IL6 IL4
36	IL 10 signaling pathway ⁶⁷	11.69	IL10 IL6 TNF
37	miRNAs involvement in the immune response in sepsis ⁷⁴	11.69	IL10 IL6 TNF
38	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.68	IFNG IL10 IL2 IL4 IL6 TNF
39	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.67	TNF IL6 IL4 IL2 IL10 IFNG
40	SARS-CoV-2 innate immunity evasion and cell-specific immune response ⁷⁴	11.65	TNF IL10 IFNB1 ACE2
41	SHP2 signaling ⁶¹	11.63	IL6 IL2 IFNG
42	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.6	TNF IL6 IFNG
43	THC Differentiation Pathway ⁶⁴	11.6	TNF IL4 IL2 IL10 IFNG CD4
44	Th2 Differentiation ⁶⁵	11.57	IL4 IL2 IL10 IFNG CD4
45	Interleukin-10 signaling ⁶⁶	11.56	TNF IL6 IL10
46	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.54	IFNG IL6 TNF
47	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.52	TNF IL6 IFNB1
48	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.47	TNF IL2 IL10 IFNG
49	Kynurenine pathway and links to cell senescence ⁷⁴ Show member pathways Tryptophan catabolism ⁶⁶	11.44	TNF IFNG IFNB1
50	IL-10 Pathway ⁶⁴	11.42	TNF IL6 IL10

Sources

GO Terms for Chickenpox

Cellular components related to Chickenpox according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	10.2	TNF IL6 IL4 IL2 IL10 IFNG
2	external side of plasma membrane	GO:0009897	9.8	ADA CCR6 CD19 CD27 CD4 CD8A
3	extracellular region	GO:0005576	9.74	TNF IL6 IL4 IL2 IL10 IFNG

Biological processes related to Chickenpox according to GeneCards Suite gene sharing:

(show all 27)

#	Name	GO ID	Score	Top Affiliating Genes
1	adaptive immune response	GO:0002250	10.29	CD19 CD4 CD8A IFNA1 IFNB1 IFNG
2	negative regulation of inflammatory response	GO:0050728	10.22	IL4 IL2 IL10 ADA
3	B cell differentiation	GO:0030183	10.16	IL4 IL10 IFNB1 IFNA1
4	calcium-mediated signaling	GO:0019722	10.15	TNF CD4 CCR6 ADA
5	cellular response to virus	GO:0098586	10.14	IFNA1 IFNB1 IFNG IL6
6	negative regulation of apoptotic process	GO:0043066	10.1	ADA ALB CD27 IL10 IL2 IL4
7	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.09	TNF IL6 IL10
8	liver regeneration	GO:0097421	10.08	IL10 IL6 TNF
9	positive regulation of immunoglobulin production	GO:0002639	10.05	IL6 IL2 IL10
10	microglial cell activation	GO:0001774	10.04	IFNG IL4 TNF
11	T cell activation	GO:0042110	10.03	IL4 CD8A CD4 ADA
12	B cell proliferation	GO:0042100	10.01	ADA IFNA1 IFNB1 IL10
13	positive regulation of peptidyl-serine phosphorylation of STAT protein	GO:0033141	9.97	IFNG IFNB1 IFNA1
14	positive regulation of mononuclear cell migration	GO:0071677	9.93	TNF IL4
15	negative regulation of cytokine production involved in immune response	GO:0002719	9.93	TNF IL10
16	positive regulation of MHC class II biosynthetic process	GO:0045348	9.93	IL4 IL10 IFNG
17	regulation of isotype switching	GO:0045191	9.91	IL4 IL10
18	positive regulation of plasma cell differentiation	GO:1900100	9.9	IL2 IL10
19	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.89	TNF IFNG
20	positive regulation of nitrogen compound metabolic process	GO:0051173	9.88	TNF IFNG
21	negative regulation of lipid storage	GO:0010888	9.85	TNF IL6 CRP
22	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.85	TNF IL6 IL4 IL2 IFNG
23	positive regulation of vitamin D biosynthetic process	GO:0060557	9.83	TNF IFNG
24	chronic inflammatory response to antigenic stimulus	GO:0002439	9.81	TNF IL10
25	positive regulation of T cell differentiation	GO:0045582	9.8	IL4 IL2 CD27 ADA
26	immune response	GO:0006955	9.8	CCR6 CD4 CD8A IFNG IL10 IL2
27	humoral immune response	GO:0006959	9.4	TNF IL6 IFNG IFNB1 IFNA1 CCR6