Chickenpox disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHC001 MIFTS: 53	Chickenpox Categories: Immune diseases, Infectious diseases, Reproductive diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Chickenpox

MalaCards integrated aliases for Chickenpox:

Name: Chickenpox ¹² ⁷⁵ ⁴³ ³ ⁴⁴ ¹⁵ ⁶³ ¹⁷ ⁷²

Varicella ¹² ⁵⁵ ¹⁵

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases Immune diseases Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Certain infectious and parasitic diseases

Viral infections characterized by skin and mucous membrane lesions

Varicella [chickenpox]

Varicella with other complications

Varicella without complication

External Ids:

Disease Ontology ¹² DOID:8659

ICD9CM ³⁵ 052

MeSH ⁴⁴ D002644

NCIt ⁵⁰ C97132

SNOMED-CT ⁶⁸ 38907003

ICD10 ³³ B01 B01.8 B01.9

EFO ¹⁷ EFO_0007204

UMLS ⁷² C0008049

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Summaries for Chickenpox

MedlinePlus : ⁴³ Chickenpox is an infection caused by the varicella-zoster virus. Most cases are in children under age 15, but older children and adults can get it. It spreads very easily from one person to another. The classic symptom of chickenpox is an uncomfortable, itchy rash. The rash turns into fluid-filled blisters and eventually into scabs. It usually shows up on the face, chest, and back and then spreads to the rest of the body. Other symptoms include Fever Headache Tiredness Loss of appetite Chickenpox is usually mild and lasts 5 to 10 days. Calamine lotions and oatmeal baths can help with itching. Acetaminophen can treat the fever. Do not use aspirin for chickenpox; that combination can cause Reye syndrome. Chickenpox can sometimes cause serious problems. Adults, babies, teenagers, pregnant women, and those with weak immune systems tend to get sicker from it. They may need to take antiviral medicines. Once you catch chickenpox, the virus usually stays in your body. You probably will not get chickenpox again, but the virus can cause shingles in adults. A chickenpox vaccine can help prevent most cases of chickenpox, or make it less severe if you do get it. Centers for Disease Control and Prevention

MalaCards based summary : Chickenpox, also known as varicella, is related to fasciitis and spindle cell sarcoma, and has symptoms including fever, myalgia and anorexia. An important gene associated with Chickenpox is GYPC (Glycophorin C (Gerbich Blood Group)), and among its related pathways/superpathways are T cell receptor signaling pathway and Cell adhesion molecules (CAMs). The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes.

Disease Ontology : ¹² A viral infectious disease that results in infection located in skin, has material basis in Human herpesvirus 3, which is transmitted by direct contact with secretions from the rash, or transmitted by droplet spread of respiratory secretions. The infection has symptom anorexia, has symptom myalgia, has symptom nausea, has symptom fever, has symptom headache, has symptom sore throat, and has symptom blisters.

CDC : ³ Chickenpox is a highly contagious disease caused by the varicella-zoster virus (VZV). It can cause an itchy, blister-like rash. The rash first appears on the chest, back, and face, and then spreads over the entire body, causing between 250 and 500 itchy blisters. Chickenpox can be serious, especially in babies, adolescents, adults, pregnant women, and people with a weakened immune system. The best way to prevent chickenpox is to get the chickenpox vaccine.

PubMed Health : ⁶³ About chickenpox: Chickenpox is a highly contagious viral infection which mainly affects children. Typical symptoms include a very itchy skin rash with red blisters and a mild fever. Because most children are now vaccinated, chickenpox (also referred to as varicella) is much less common than it was in the past. If someone comes down with chickenpox, they are contagious after just one or two days, which is before they have a visible rash. But taking precautions and improving hygiene can help to avoid infecting others. Although chickenpox is unpleasant, it rarely has any serious consequences in children who are otherwise healthy. But it may become more severe in newborns and adults, as well as people who have a weakened immune system.

Wikipedia : ⁷⁵ Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with... more...

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Related Diseases for Chickenpox

Diseases related to Chickenpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 938)

#	Related Disease	Score	Top Affiliating Genes
1	fasciitis	31.3	MUC1 ACTC1
2	spindle cell sarcoma	30.2	MUC1 ACTC1
3	mammary paget's disease	30.1	PGR MUC1
4	cryptogenic organizing pneumonia	30.0	MUC1 CD8A
5	pneumothorax	29.8	PGR MUC1
6	varicella, severe recurrent	12.2
7	herpes zoster	12.2
8	congenital varicella syndrome	12.1
9	geniculate herpes zoster	11.8
10	postherpetic neuralgia	11.7
11	myoclonus and ataxia	11.6
12	cytomegalic inclusion disease	11.5
13	cytomegalovirus infection	11.3
14	immunodeficiency 50	11.2
15	immunodeficiency 24	11.2
16	salivary gland disease	11.2
17	neurological consequences of cytomegalovirus infection	11.2
18	infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformations	11.1
19	immunodeficiency 62	11.1
20	idiopathic cd4-positive t-lymphocytopenia	11.1
21	adult-onset immunodeficiency with anti-interferon-gamma autoantibodies	11.1
22	torch syndrome	11.1
23	measles	10.7
24	exanthem	10.7
25	cutaneous leiomyosarcoma	10.7	MUC1 ACTC1
26	calcifying aponeurotic fibroma	10.7	PGR ACTC1
27	syringocystadenoma papilliferum	10.7	MUC1 ACTC1
28	parachordoma	10.6	MUC1 ACTC1
29	myxoid leiomyosarcoma	10.6	PGR ACTC1
30	ossifying fibromyxoid tumor	10.6	MUC1 ACTC1
31	bizarre leiomyoma	10.6	PGR ACTC1
32	breast mucoepidermoid carcinoma	10.6	PGR MUC1
33	breast scirrhous carcinoma	10.6	PGR MUC1
34	benign metastasizing leiomyoma	10.6	PGR ACTC1
35	endosalpingiosis	10.6	PGR MUC1
36	adenofibroma	10.6	MUC1 ACTC1
37	spiradenoma	10.6	MUC1 ACTC1
38	cystadenoma	10.6	PGR MUC1
39	ischemic fasciitis	10.6	MUC1 ACTC1
40	apocrine adenocarcinoma	10.6	PGR MUC1
41	endometrial mucinous adenocarcinoma	10.6	PGR MUC1
42	glycogen-rich clear cell breast carcinoma	10.6	PGR ACTC1
43	clear cell meningioma	10.6	PGR MUC1
44	pneumonia	10.6
45	sertoli cell tumor	10.6	PGR MUC1
46	dendritic cell tumor	10.6	MUC1 ACTC1
47	sclerosing hemangioma	10.6	PGR MUC1
48	mumps	10.6
49	sertoli-leydig cell tumor	10.6	PGR MUC1
50	dermoid cyst	10.6	PGR MUC1

Graphical network of the top 20 diseases related to Chickenpox:

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Symptoms & Phenotypes for Chickenpox

Symptoms:

¹²

• fever
• myalgia
• anorexia
• headache

• nausea
• sore throat
• blisters

UMLS symptoms related to Chickenpox:

fever, pruritus, exanthema

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Drugs & Therapeutics for Chickenpox

PubMed Health treatment related to Chickenpox: ⁶³

The treatment usually focuses on relieving the symptoms of chickenpox. In more severe cases, or if there is a greater risk of complications, antiviral drugs can be used to fight off the virus. Lotions, gels and powders are often applied in order to relieve itching and dry out the blisters. Most of them contain tanins, zinc, menthol or polidocanol. Sometimes oral medication like antihistamines is also recommended to stop the itching. But there is no good-quality scientific research on how effective they are. Symptoms like fever or aching muscles can be relieved using medicine that contains acetaminophen (paracetamol). The painkiller ibuprofen is not suitable for children with chickenpox. Children and teenagers should only take acetylsalicylic acid (ASA, the drug in medicines like Aspirin) if it has been prescribed by a doctor, and only as a last resort. This is because it can cause a rare but dangerous side effect called Reye’s syndrome in children and teenagers.

Drugs for Chickenpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 179)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

6741

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

5755

Ethanol

Approved

Phase 4

64-17-5

702

Budesonide

Approved

Phase 4

51333-22-3

63006 5281004

Interferon beta-1a

Approved, Investigational

Phase 4

145258-61-3

6438354

Interferon beta-1b

Approved

Phase 4

145155-23-3

Fluticasone

Approved, Experimental

Phase 4

90566-53-3

62924

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Racepinephrine

Approved

Phase 4

329-65-7

838

Mercaptopurine

Approved

Phase 4

50-44-2

667490

Certolizumab pegol

Approved

Phase 4

428863-50-7

Adalimumab

Approved

Phase 4

331731-18-1

16219006

Azathioprine

Approved

Phase 4

446-86-6

2265

Tofacitinib

Approved, Investigational

Phase 4

477600-75-2

Methotrexate

Approved

Phase 4

1959-05-2, 59-05-2

126941

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

Hormone Antagonists

Phase 4

glucocorticoids

Phase 4

Hormones

Phase 4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4

Methylprednisolone Acetate

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

Prednisolone acetate

Phase 4

Vaccines

Phase 4

Anti-Inflammatory Agents

Phase 4

Peripheral Nervous System Agents

Phase 4

Respiratory System Agents

Phase 4

Anti-Asthmatic Agents

Phase 4

Autonomic Agents

Phase 4

Bronchodilator Agents

Phase 4

Anti-Infective Agents, Local

Phase 4

Dermatologic Agents

Phase 4

Fingolimod Hydrochloride

Phase 4

(T,G)-A-L

Phase 4

Interferon-beta

Phase 4

Glatiramer Acetate

Phase 4

147245-92-9

3081884

interferons

Phase 4

Anti-Allergic Agents

Phase 4

Epinephryl borate

Phase 4

Antiviral Agents

Phase 4

valacyclovir

Phase 4

Mesalamine

Phase 4

89-57-6

Heptavalent Pneumococcal Conjugate Vaccine

Phase 4

Protein Kinase Inhibitors

Phase 4

Janus Kinase Inhibitors

Phase 4

polysaccharide-K

Phase 4

Methylene blue

Approved, Investigational

Phase 3

61-73-4

Interventional clinical trials:

(show top 50) (show all 253)

#	Name	Status	NCT ID	Phase	Drugs
1	A Study of Immune Persistence After Inoculated With One-dose Freeze-dried Live Attenuated Varicella Vaccine in Children Aged 1-6 Years	Unknown status	NCT01982409	Phase 4
2	Study on Effectiveness of 2-dose Live Attenuated Varicella Vaccine	Unknown status	NCT02146469	Phase 4
3	Phase 4 Study of the Varicella Vaccine After the 2nd Dose Vaccination	Unknown status	NCT01830283	Phase 4
4	Phase 4 Study of Live Attenuated Varicella Vaccine After the 2 Doses Vaccination	Unknown status	NCT01866566	Phase 4
5	Safety and Immunogenicity of Live Attenuated Herpes Zoster Vaccine in Patients Undergoing Living Donor Kidney Transplantations	Unknown status	NCT00940940	Phase 4
6	A Pilot Study to Characterize the Immune Response Induced by a Commercial Varicella Zoster Virus Vaccine in Healthy Adult Females in Nairobi, Kenya.	Unknown status	NCT02514018	Phase 4
7	Immunodeficiency in Cartilage-hair Hypoplasia: Correlation With Pulmonary Disease, Infections and Malignancy	Unknown status	NCT02383797	Phase 4
8	Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children	Unknown status	NCT00494624	Phase 4	prednisolone
9	A Study to Evaluate the Immunogenicity and Safety of 2 Doses of Live Attenuated Varicella Vaccine	Completed	NCT01817270	Phase 4
10	Rates of Seroconversion Following Varicella Vaccination of Asthmatic Children Between the Ages of One and Eight Years Treated With Pulmicort Respules® Versus Non-Steroidal Conventional Asthma Therapy	Completed	NCT00641446	Phase 4	budesonide;varicella zoster virus
11	A Study to Evaluate the Immunogenicity and Safety of 2 Doses of Live Attenuated Varicella Vaccine	Completed	NCT02173899	Phase 4
12	Blinded, Randomised Study to Assess the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Live Attenuated Measles-mumps-rubella-varicella Candidate Vaccine When Given to Healthy Children in Their Second Year of Life	Completed	NCT00126997	Phase 4
13	A Study to Evaluate the Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Live Attenuated JE Vaccine	Completed	NCT01815073	Phase 4
14	Safety of a Second Dose of Biken's Varicella Vaccine Administered at 4 to 6 Years of Age in Healthy Children in Argentina	Completed	NCT00830648	Phase 4
15	A Double-blind, Randomised, Controlled, Multi-centre Safety Study of a Refrigerator-stable Formulation of VARIVAX® in Healthy 12 to 15 Month-old Infants.	Completed	NCT00432731	Phase 4
16	Evaluation of Safety and Immunogenicity Receiving Live Attenuated Vaccine Against Varicella Without Gelatin	Completed	NCT01684072	Phase 4
17	An Open, Multicenter Study of the Safety and Tolerability of VAQTA(TM) and ProQuad(TM) in Healthy Children 12 to 23 Months of Age	Completed	NCT00326183	Phase 4
18	Live Attenuated Varicella Vaccine: A New Effective Adjuvant Weapon in the Battlefield Against Severe Resistant Psoriasis, a Randomized Controlled Trial	Completed	NCT01356004	Phase 4	live attenuated chicken pox vaccine;saline, efficacy
19	The Immunogenicity of Varicella-zoster Virus Vaccine in HIV-infected Children	Completed	NCT01138215	Phase 4
20	T Cell Responses to Varicella Zoster Virus After Vaccination and Viral Escape	Completed	NCT01911065	Phase 4
21	An Open, Randomized, Multicenter Study of the Safety, Tolerability, & Immunogenicity of VAQTA™ Given Concomitantly With PROQUAD™ and PREVNAR™ in Healthy Children 12 Months of Age	Completed	NCT00312858	Phase 4
22	An Open-label, Single-arm, Phase IV Study Assessing the Immunogenicity and Safety of ZOSTAVAX® at Minimum Release Specification Approaching Expiry Potency in Subjects ≥50 Years Old.	Completed	NCT00681031	Phase 4
23	Palatability Testing of a New Paediatric Formulation of Valacyclovir for the Prophylaxis and Treatment of VZV and HSV Infections in Children	Completed	NCT01682109	Phase 4	Valacyclovir
24	Effectiveness Assessment of Vaccinating Schoolchildren Against Influenza the in São Paulo, 2009	Completed	NCT01693380	Phase 4
25	Placebo Controlled Evaluation of the Cell Mediated Immune Response of Cirrhotic Subjects to Zostavax™	Completed	NCT02958345	Phase 4
26	Immunogenicity and Safety of a Tetanus-diphtheria Vaccine and a 13-valent Pneumococcal Conjugate Vaccine After Concomitant Vaccination in ≥50-year-old Adults	Completed	NCT03552445	Phase 4
27	The Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection Adaptive Immune Responses and Repertoire in Influenza Vaccination and Infection	Completed	NCT03453801	Phase 4
28	A 12-month, Prospective, Randomized, Active-controlled, Open-label Study to Evaluate the Patient Retention of Fingolimod vs. Approved First-line Disease Modifying Therapies in Adults With Relapsing Remitting Multiple Sclerosis (PREFERMS)	Completed	NCT01623596	Phase 4	Fingolimod;Disease Modifying therapy
29	Multicenter Randomised Controlled Trial of Episodic Fluticasone Versus Placebo in Viral-induced Asthma in Children	Completed	NCT00238927	Phase 4	inhaled fluticasone 750 mcg/day twice daily until 2 days without symptoms (maximum 15 consecutive days)
30	Double-Blind Placebo-Controlled Clinical Effectiveness Trial of the 23-Valent Pneumococcal Vaccine Among Military Trainees At Increased Risk of Respiratory Disease	Completed	NCT02079701	Phase 4
31	Safety and Immunogenicity of Measles Vaccine, Varicella Vaccine and Hepatitis-A Vaccine in HIV-exposed and HIV-unexposed South African Children	Recruiting	NCT03330171	Phase 4
32	Occupational Exposure to Human Papilloma Virus (HPV) and Prophylactic Vaccination (Version IV Dated 24Oct2017)	Recruiting	NCT03350698	Phase 4
33	Immune Response to Shingles Vaccination	Recruiting	NCT02624375	Phase 4	Zoster Vaccine Live
34	Safety and Immunogenicity of Non-live, Recombinant Subunit Herpes Zoster Vaccine Before and After Lung Transplantation	Recruiting	NCT03493776	Phase 4
35	Safety and Tolerability of Herpes Zoster Vaccine in Patients With Rheumatoid Arthritis Immunized Prior to Biologics and Tofacitinib Therapy Initiation	Recruiting	NCT03016884	Phase 4
36	The Immunogenicity and Safety of Shingrix Vaccine in Patients With Moderate to Severe Ulcerative Colitis on Tofacitinib	Recruiting	NCT03591770	Phase 4
37	Long-term Suppressive Valacyclovir Treatment for Herpes Zoster Ophthalmicus	Recruiting	NCT03134196	Phase 4	Masked Placebo;Masked Oral Valacyclovir
38	Immunogenicity and Safety of a Herpes Zoster Vaccine (Zostavax) in Patients With Systemic Lupus Erythematosus: a Randomized Controlled Trial	Active, not recruiting	NCT02477150	Phase 4
39	Vaccinating Children After Chemotherapy for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study	Active, not recruiting	NCT02447718	Phase 4
40	Persistence of Varicella Immunity in Hospital Employees Receiving Varicella Vaccine	Not yet recruiting	NCT02026089	Phase 4
41	The Immunogenicity and Efficacy of Subunit Vaccine Against Herpes Zoster in RA Treated With JAK-inhibitors (VACCIMIL-ZOSTER)	Not yet recruiting	NCT03886038	Phase 4
42	Safety and Immunogenicity of Recombinant Glycoprotein E Herpes Zoster Subunit (HZ/su) Vaccine in Renal Transplant Recipients	Not yet recruiting	NCT03993717	Phase 4
43	A Double Blind Placebo-controlled Randomized Study of Varicella Zoster Vaccine in Patients With Moderate-to-severe Plaque Psoriasis Who Are Candidates for Biologic Therapy	Terminated	NCT02408159	Phase 4	Varicella Zoster Vaccine;Placebo
44	Induction and Maintenance of Immunity Against Varicella in Pediatric Orthotopic Liver Transplantation Recipients: a Retrospective and Prospective Nationwide Study in Switzerland	Unknown status	NCT00492739	Phase 2, Phase 3
45	Serological Evaluation of Chickenpox (Varicella) and Hepatitis A Vaccines Using Disposable Needle-Free Syringe Jet Injector (DSJI) Delivery	Unknown status	NCT00926419	Phase 2, Phase 3
46	Safety and Immunogenicity of Live Attenuated Oka/Merck Varicella Vaccine in Children Listed to Undergo Solid Organ Transplantation	Unknown status	NCT00213304	Phase 3
47	A Comparative Study of Tzanck Smear With Methylene Blue Versus Giemsa Stain to Diagnose Herpes Simplex, Herpes Zoster and Varicella Zoster Skin Infections	Unknown status	NCT03178747	Phase 3
48	Clinical Evaluation of Valaciclovir Hydrochloride: 256U87 in Patients With Chickenpox - Open Uncontrolled Study.	Completed	NCT00169416	Phase 3	valaciclovir HCl granules
49	Pharmacokinetics and Safety of Famciclovir Oral Pediatric Formulation in Children 1-12 Years of Age With Varicella Zoster Infection	Completed	NCT00098046	Phase 3	famciclovir
50	Blinded, Randomised, Controlled Study to Evaluate the Immunogenicity and Safety of GlaxoSmithKline Biologicals' Combined Measles-mumps-rubella-varicella Candidate Vaccine Given to Healthy Children in Their Second Year of Life	Completed	NCT00127023	Phase 3

Search NIH Clinical Center for Chickenpox

Inferred drug relations via UMLS ⁷² / NDF-RT ⁵¹ :

Acyclovir

Acyclovir Sodium

Measles virus strain enders' attenuated edmonston live antigen

Mumps virus strain b level jeryl lynn live antigen

Rubella virus vaccine

Valaciclovir

Varicella Zoster Vaccine (Live/Attenuated)

Cochrane evidence based reviews: chickenpox

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Genetic Tests for Chickenpox

Sources

Anatomical Context for Chickenpox

MalaCards organs/tissues related to Chickenpox:

⁴¹

Skin, T Cells, Testes, Bone, Bone Marrow, Liver, Brain

The Foundational Model of Anatomy Ontology organs/tissues related to Chickenpox:

¹⁹

Skin

Sources

Publications for Chickenpox

Articles related to Chickenpox:

(show top 50) (show all 14905)

#	Title	Authors	PMID	Year
1	Burden of varicella in Latin America and the Caribbean: findings from a systematic literature review. ³⁸ ¹⁷	Arlant LHF...Wolfson LJ	31068173	2019
2	Immunogenicity, Safety, and Tolerability of Live Attenuated VaricellaZoster Virus Vaccine (ZOSTAVAX™) in Healthy Adults in India. ³⁸ ¹⁷	Sreenivasamurthy L...Naik R	31325263	2018
3	Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial. ¹⁷	Bastidas A...ZOE-HSCT Study Group Collaborators	31287523	2019
4	[Adenosine deaminase deficiency associated severe combined immunodeficiency with disseminated varicella infection after vaccination: a case report]. ⁹ ³⁸	Zhang WX...Zhao W	19099832	2008
5	[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]. ⁹ ³⁸	Morfin F...Thouvenot D	12604384	2003
6	New variant of varicella-zoster virus. ⁹ ³⁸	Tipples GA...Grose C	12498673	2002
7	Expression of the simian varicella virus glycoprotein E. ⁹ ³⁸	Gray WL...Soike KF	11551643	2001
8	Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants. ⁹ ³⁸	Ida M...Shiraki K	10027650	1999
9	Identification of immunodominant regions and linear B cell epitopes of the gE envelope protein of varicella-zoster virus. ⁹ ³⁸	Fowler WJ...Layton GT	8553555	1995
10	Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine. ⁹ ³⁸	Kodama E...Shigeta S	7486953	1995
11	Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine. ⁹ ³⁸	Keizer HJ...De Clercq E	8045919	1994
12	Susceptibility of Oka varicella vaccine strain to antiviral drugs. ⁹ ³⁸	Shiraki K...Aiba N	8310756	1993
13	Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity. ³⁸	de Oliveira Costa GN...Barreto ML	31357023	2019
14	Ramsay Hunt syndrome: a rare complication of herpes zoster infection in a lung cancer patient. ³⁸	Mercier T...Nackaerts K	30189789	2019
15	Progeny Varicella-Zoster Virus Capsids Exit the Nucleus but Never Undergo Secondary Envelopment during Autophagic Flux Inhibition by Bafilomycin A1. ³⁸	Girsch JH...Grose C	31217243	2019
16	Age at cytomegalovirus, Epstein Barr virus and varicella zoster virus infection and risk of atopy: The Born in Bradford cohort, UK. ³⁸	Pembrey L...Wright J	31188509	2019
17	Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes: a CIBMTR contemporary longitudinal study. ³⁸	Abidi MZ...Riches M	30696997	2019
18	Infectious causes of peripheral facial nerve palsy in children-a retrospective cohort study with long-term follow-up. ³⁸	Papan C...Tenenbaum T	31372902	2019
19	Pathogen-Specific T Cells Beyond CMV, EBV and Adenovirus. ³⁸	Jiang W...Blyth E	31228095	2019
20	Quantification of a cell-mediated immune response against varicella zoster virus by assessing responder CD4high memory cell proliferation in activated whole blood cultures. ³⁸	Haredy AM...Ebina H	31358406	2019
21	Avoiding a lumbar puncture may be a rash decision: a case report of varicella-zoster virus-associated radiculopathy in advanced HIV infection. ³⁸	Wallis E...Kulasegaram R	31403892	2019
22	Prudence Using Serology to Determine Vaccine-Induced Immunity to Measles and Varicella in Patients With Inflammatory Bowel Disease. ³⁸	Caldera F...Hayney MS	31165856	2019
23	Otherwise Healthy 15-Month-Old With Rapid-Onset Soft Tissue Swelling. ³⁸	Anderson JJ...Kaila R	31373950	2019
24	Varicella zoster virus vaccine in patients with haematological malignancies. ³⁸	Ljungman P	31399379	2019
25	Measles, mumps, rubella (vaccine) and varicella vaccines in pediatric liver transplant: An initial analysis of post-transplant immunity. ³⁸	Yoeli JK...Munoz-Rivas F	31219224	2019
26	Field Test and Validation of the Multiplier Measles, Mumps, Rubella, and Varicella-Zoster Multiplexed Assay System in the Democratic Republic of the Congo by Using Dried Blood Spots. ³⁸	Higgins SG...Rimoin AW	31413172	2019
27	Calibration and Evaluation of Quantitative Antibody Titers for Varicella-Zoster Virus by Use of the BioPlex 2200. ³⁸	McLachlan E...Immunity of Canadians and Risk of Epidemics (iCARE) Laboratory Group and the Canadian Immunization Research Network (CIRN)	31167847	2019
28	Safety and efficacy of inactivated varicella zoster virus vaccine in immunocompromised patients with malignancies: a two-arm, randomised, double-blind, phase 3 trial. ³⁸	Mullane KM...V212 Protocol 011 Trial Team	31399378	2019
29	Estradiol Acts in Lateral Thalamic Region to Attenuate Varicella Zoster Virus Associated Affective Pain. ³⁸	Stinson C...Kramer PR	31271831	2019
30	Do varicella vaccination programs change the epidemiology of herpes zoster? A comprehensive review, with focus on the United States. ³⁸	Harpaz R	31318605	2019
31	Reply letter: trends in varicella and herpes zoster epidemiology before and after the implementation of universal one-dose varicella vaccination over one decade in South Korea, 2003-2015. ³⁸	Park SH...Kang JH	31311411	2019
32	[Therapy of herpes zoster and postherpetic neuralgia]. ³⁸	Huning S...Nashan D	31270550	2019
33	The changing epidemiology of herpes zoster over a decade in South Korea, 2006-2015. ³⁸	Choi JK...Yoo JH	31377077	2019
34	Herpes zoster vaccination efficacy in the long-term care facility population: a qualitative systematic review. ³⁸	Senderovich H...Mujtaba M	30913912	2019
35	Epidemiology of viral infections among children undergoing hematopoietic stem cell transplant: Α prospective single-center study. ³⁸	Tsoumakas K...Pavlopoulou ID	30993823	2019
36	Concomitant dengue fever in Varicella zoster infection - A rare presentation. ³⁸	Shaiful Ehsan SM...Mohd Ashraf AR	31424049	2019
37	Prevention of Opportunistic Infections in Women With HIV Infection. ³⁸	Duff P	31433312	2019
38	The clinical and economic burden of varicella in the Middle East: a systematic literature review. ³⁸	Al Kaabi N...Wolfson LJ	31373864	2019
39	Gadolinium enhancement in perforating arteries in a patient with varicella zoster virus vasculopathy: A case report. ³⁸	Yamaguchi Y...Wada M	31276861	2019
40	Varicella-zoster virus vasculopathy in a multiple sclerosis patient on fingolimod. ³⁸	Muccilli A...Poppe AY	31276860	2019
41	Development of Acute Retinal Necrosis in a Patient with Ocular Sarcoidosis: A Case Report. ³⁸	Takayama K...Takeuchi M	31414927	2019
42	Chronic myelitis associated with zoster sine herpete: A case report. ³⁸	Miyake Z...Tamaoka A	31393366	2019
43	Varicella Zoster Virus Encephalitis Mimicking Nivolumab-Induced Autoimmune Neuropathy in a Patient with Lung Cancer. ³⁸	Watanabe Y...Aoshiba K	31345336	2019
44	Long-segment transverse myelitis in an immunocompetent patient due to varicella zoster virus reactivation. ³⁸	Goyal T...Khan Z	31376078	2019
45	Ultrasound-guided peri-brachial plexus polydeoxyribonucleotide injection for a patient with postherpetic brachial plexopathy: A case report. ³⁸	Kim JY...Park D	31374058	2019
46	Adjuvant treatment of severe varicella pneumonia with intravenous varicella zoster virus-specific immunoglobulins. ³⁸	Mangioni D...Bandera A	31132473	2019
47	Varicella Virus Vaccine Live: A 22-Year Review of Postmarketing Safety Data. ³⁸	Woodward M...Straus W	31392326	2019
48	Acute ataxia in paediatric emergency departments: a multicentre Italian study. ³⁸	Garone G...Raucci U	30948362	2019
49	Neurologic Acyclovir Toxicity in the Absence of Kidney Injury. ³⁸	Patel J...Mastenbrook J	31171414	2019
50	Safety and Seropositivity after Live Attenuated Vaccine in Adult Patients Receiving Hematopoietic Stem Cell Transplantation. ³⁸	Aoki T...Miyamoto T	30959161	2019

Sources

Genes for Chickenpox

Genes related to Chickenpox (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	GYPC	Glycophorin C (Gerbich Blood Group)	Protein Coding	21.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	8553555 11551643 12498673
2	CD40LG	CD40 Ligand	Protein Coding	17.45	DISEASES inferred ¹⁵
3	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	16.78	GeneCards inferred via : Publications (show sections)
4	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	16.78	GeneCards inferred via : Publications (show sections)
5	PGR	Progesterone Receptor	Protein Coding	16.78	GeneCards inferred via : Publications (show sections)
6	CD4	CD4 Molecule	Protein Coding	16.5	DISEASES inferred ¹⁵
7	AMHR2	Anti-Mullerian Hormone Receptor Type 2	Protein Coding	16.14	DISEASES inferred ¹⁵
8	CD8A	CD8a Molecule	Protein Coding	15.91	DISEASES inferred ¹⁵
9	TRIM23	Tripartite Motif Containing 23	Protein Coding	15.89	DISEASES inferred ¹⁵
10	ADA	Adenosine Deaminase	Protein Coding	15.83	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	19099832
11	DNAJC28	DnaJ Heat Shock Protein Family (Hsp40) Member C28	Protein Coding	15.16	DISEASES inferred ¹⁵
12	CTTNBP2	Cortactin Binding Protein 2	Protein Coding	14.88	DISEASES inferred ¹⁵
13	POLR3C	RNA Polymerase III Subunit C	Protein Coding	14.88	DISEASES inferred ¹⁵

Sources

Variations for Chickenpox

Sources

Expression for Chickenpox

Search GEO for disease gene expression data for Chickenpox.

Sources

Pathways for Chickenpox

Pathways related to Chickenpox according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	T cell receptor signaling pathway ³⁷ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁷ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	11.87	CD8A CD40LG CD4
2	Cell adhesion molecules (CAMs) ³⁷	11.3	CD8A CD40LG CD4
3	Primary immunodeficiency ³⁷	10.49	CD8A CD40LG CD4 ADA

Sources

GO Terms for Chickenpox

Cellular components related to Chickenpox according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.43	MUC1 GYPC CD8A CD40LG CD4 AMHR2
2	T cell receptor complex	GO:0042101	9.16	CD8A CD4
3	external side of plasma membrane	GO:0009897	8.92	CD8A CD40LG CD4 ADA

Biological processes related to Chickenpox according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lung alveolus development	GO:0048286	9.26	PGR ADA
2	positive regulation of T cell activation	GO:0050870	9.16	CD4 ADA
3	positive regulation of calcium-mediated signaling	GO:0050850	8.96	CD4 ADA
4	T cell activation	GO:0042110	8.8	CD8A CD4 ADA

Molecular functions related to Chickenpox according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:0015026	8.62	CD8A CD4

Sources

Sources for Chickenpox

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia

Chickenpox

Aliases & Classifications for Chickenpox

MalaCards integrated aliases for Chickenpox:

Classifications:

External Ids:

Summaries for Chickenpox

Related Diseases for Chickenpox

Diseases related to Chickenpox via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Chickenpox:

Symptoms & Phenotypes for Chickenpox

Symptoms:

UMLS symptoms related to Chickenpox:

Drugs & Therapeutics for Chickenpox

PubMed Health treatment related to Chickenpox: 63

Drugs for Chickenpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 72 / NDF-RT 51 :

Cochrane evidence based reviews: chickenpox

Genetic Tests for Chickenpox

Anatomical Context for Chickenpox

MalaCards organs/tissues related to Chickenpox:

The Foundational Model of Anatomy Ontology organs/tissues related to Chickenpox:

Publications for Chickenpox

Articles related to Chickenpox:

Genes for Chickenpox

Genes related to Chickenpox (0 elite genes):

Variations for Chickenpox

Expression for Chickenpox

Pathways for Chickenpox

Pathways related to Chickenpox according to GeneCards Suite gene sharing:

GO Terms for Chickenpox

Cellular components related to Chickenpox according to GeneCards Suite gene sharing:

Biological processes related to Chickenpox according to GeneCards Suite gene sharing:

Molecular functions related to Chickenpox according to GeneCards Suite gene sharing:

Sources for Chickenpox

PubMed Health treatment related to Chickenpox: ⁶³

Inferred drug relations via UMLS ⁷² / NDF-RT ⁵¹ :