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MIFTS: 60

Chickenpox

Categories: Immune diseases, Infectious diseases, Reproductive diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Chickenpox

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MalaCards integrated aliases for Chickenpox:

Name: Chickenpox 12 74 42 3 15 62 17 71
Varicella 12 54 15

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases Immune diseases Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8659
ICD9CM 34 052
NCIt 49 C97132
SNOMED-CT 67 38907003
ICD10 32 B01 B01.8 B01.9
UMLS 71 C0008049
Sources

Summaries for Chickenpox

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MedlinePlus : 42 Chickenpox is an infection caused by the varicella-zoster virus. Most cases are in children under age 15, but older children and adults can get it. It spreads very easily from one person to another. The classic symptom of chickenpox is an uncomfortable, itchy rash. The rash turns into fluid-filled blisters and eventually into scabs. It usually shows up on the face, chest, and back and then spreads to the rest of the body. Other symptoms include Fever Headache Tiredness Loss of appetite Chickenpox is usually mild and lasts 5 to 10 days. Calamine lotions and oatmeal baths can help with itching. Acetaminophen can treat the fever. Do not use aspirin for chickenpox; that combination can cause Reye syndrome. Chickenpox can sometimes cause serious problems. Adults, babies, teenagers, pregnant women, and those with weak immune systems tend to get sicker from it. They may need to take antiviral medicines. Once you catch chickenpox, the virus usually stays in your body. You probably will not get chickenpox again, but the virus can cause shingles in adults. A chickenpox vaccine can help prevent most cases of chickenpox, or make it less severe if you do get it. Centers for Disease Control and Prevention

MalaCards based summary : Chickenpox, also known as varicella, is related to herpes zoster and salivary gland disease, and has symptoms including fever, myalgia and anorexia. An important gene associated with Chickenpox is GYPC (Glycophorin C (Gerbich Blood Group)), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are hematopoietic system and cellular

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Human herpesvirus 3, which is transmitted by direct contact with secretions from the rash, or transmitted by droplet spread of respiratory secretions. The infection has symptom anorexia, has symptom myalgia, has symptom nausea, has symptom fever, has symptom headache, has symptom sore throat, and has symptom blisters.

CDC : 3 Chickenpox is a highly contagious disease caused by the varicella-zoster virus (VZV). It can cause an itchy, blister-like rash. The rash first appears on the chest, back, and face, and then spreads over the entire body, causing between 250 and 500 itchy blisters. Chickenpox can be serious, especially in babies, adolescents, adults, pregnant women, and people with a weakened immune system. The best way to prevent chickenpox is to get the chickenpox vaccine.

PubMed Health : 62 About chickenpox: Chickenpox is a highly contagious viral infection which mainly affects children. Typical symptoms include a very itchy skin rash with red blisters and a mild fever. Because most children are now vaccinated, chickenpox (also referred to as varicella) is much less common than it was in the past. If someone comes down with chickenpox, they are contagious after just one or two days, which is before they have a visible rash. But taking precautions and improving hygiene can help to avoid infecting others. Although chickenpox is unpleasant, it rarely has any serious consequences in children who are otherwise healthy. But it may become more severe in newborns and adults, as well as people who have a weakened immune system.

Wikipedia : 74 Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with... more...

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Related Diseases for Chickenpox

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Diseases related to Chickenpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1323)
# Related Disease Score Top Affiliating Genes
1 herpes zoster 32.7 TNF IL2 IFNG IFNA1 GYPC CRP
2 salivary gland disease 31.8 TNF IL6 IL2 CD8A CD40LG CD4
3 neuroretinitis 31.3 CRP CD40LG CD4
4 keratitis, hereditary 31.3 TNF IL6 CD4 CCR6
5 parotitis 31.3 CRP CD40LG CD4
6 smallpox 31.1 TNF IL2 IFNG
7 facial paralysis 31.1 CRP CD8A CD40LG CD4
8 vasculitis 31.1 TNF IL6 CRP CD40LG
9 purpura 31.0 TNF IL6 IFNG CRP CD40LG
10 streptococcal toxic-shock syndrome 31.0 TNF IL6 IL2
11 scarlet fever 31.0 TNF CRP CD40LG
12 encephalitis 31.0 TNF IL6 IFNB1 IFNA1 CD40LG
13 acute retinal necrosis syndrome 31.0 GYPC CD8A CD40LG CD4
14 acute disseminated encephalomyelitis 30.9 IFNB1 CD40LG CCR6
15 necrotizing fasciitis 30.9 IL6 IL2 CRP
16 thrombocytopenic purpura, autoimmune 30.9 CD40LG CD4 CCR6
17 measles 30.9 TNF IL6 IL2 IFNG IFNB1 IFNA1
18 genital herpes 30.9 GYPC CD8A CD40LG CD4 CCR6
19 graft-versus-host disease 30.9 TNF IL6 IL2 IFNG
20 cranial nerve palsy 30.9 CRP CD40LG CD4
21 transverse myelitis 30.8 TNF IL6 CD27
22 neuritis 30.8 TNF IL6 IFNG
23 guillain-barre syndrome 30.8 TNF CD40LG CCR6
24 rubella 30.8 TNF IL6 IL2 IFNG IFNB1 CD40LG
25 chronic graft versus host disease 30.8 IFNG CD4
26 thrombophlebitis 30.8 TNF CRP CD40LG
27 uveitis 30.8 TNF IL6 IL2 IFNG
28 pleural empyema 30.8 CRP CD40LG CD4 ADA
29 covid-19 30.8 IL6 CRP CD8A
30 mumps 30.7 TNF IL6 IL2 IFNG IFNB1 IFNA1
31 pars planitis 30.7 IL2 CD27 CCR6
32 vaccinia 30.7 TNF MUC1 IL6 IL2 IFNB1 IFNA1
33 cold agglutinin disease 30.7 IL6 CRP
34 pneumothorax 30.7 PGR MUC1 CRP ACTC1
35 retinal vasculitis 30.7 TNF IFNB1 CD40LG CD4 CCR6
36 iridocyclitis 30.6 TNF IL6 CRP CD40LG CD4
37 erythema multiforme 30.6 TNF IL6 IL2 IFNG
38 myelitis 30.6 TNF IL6 IFNB1 CD40LG CD27 CCR6
39 acute myocarditis 30.6 TNF CRP CD4
40 granulomatous dermatitis 30.6 TNF CD40LG CD4
41 hemophagocytic lymphohistiocytosis 30.6 TNF IFNG CD27
42 monkeypox 30.6 IFNA1 CD8A CD40LG CD4
43 congenital toxoplasmosis 30.6 CD8A CD40LG CD4
44 pyoderma 30.6 TNF CRP CD40LG CCR6
45 secondary syphilis 30.5 CD8A CD40LG CD4
46 allergic hypersensitivity disease 30.5 TNF IL2 IFNG CD4 CCR6
47 hemolytic anemia 30.5 TNF IL2 IFNG CD40LG ADA
48 ileus 30.5 TNF IL6 IFNG CRP
49 pustulosis of palm and sole 30.5 TNF CRP CCR6
50 macular retinal edema 30.5 TNF IL6 IFNB1

Graphical network of the top 20 diseases related to Chickenpox:



Diseases related to Chickenpox
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Symptoms & Phenotypes for Chickenpox

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Symptoms:

12
  • • fever
  • • myalgia
  • • anorexia
  • • headache
  • • nausea
  • • sore throat
  • • blisters

UMLS symptoms related to Chickenpox:


fever, pruritus, exanthema

MGI Mouse Phenotypes related to Chickenpox:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.2 ADA CCR6 CD19 CD27 CD4 CD40LG
2 cellular MP:0005384 10.18 ACTC1 ADA CD19 CD27 CD4 CD40LG
3 cardiovascular system MP:0005385 10.14 ACTC1 ADA CCR6 CD19 CD40LG CRP
4 homeostasis/metabolism MP:0005376 10.1 ACTC1 ADA CCR6 CD19 CD4 CD40LG
5 immune system MP:0005387 10.03 ADA CCR6 CD19 CD27 CD4 CD40LG
6 neoplasm MP:0002006 9.5 CD19 IFNB1 IFNG IL2 IL6 PGR
7 normal MP:0002873 9.28 ACTC1 ADA CCR6 CD19 CD4 CD8A
Sources

Drugs & Therapeutics for Chickenpox

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PubMed Health treatment related to Chickenpox: 62

The treatment usually focuses on relieving the symptoms of chickenpox . In more severe cases, or if there is a greater risk of complications, antiviral drugs can be used to fight off the virus. Lotions, gels and powders are often applied in order to relieve itching and dry out the blisters . Most of them contain tanins, zinc , menthol or polidocanol . Sometimes oral medication like antihistamines is also recommended to stop the itching. But there is no good-quality scientific research on how effective they are. Symptoms like fever or aching muscles can be relieved using medicine that contains acetaminophen (paracetamol). The painkiller ibuprofen is not suitable for children with chickenpox . Children and teenagers should only take acetylsalicylic acid (ASA, the drug in medicines like Aspirin ) if it has been prescribed by a doctor, and only as a last resort. This is because it can cause a rare but dangerous side effect called Reye’s syndrome in children and teenagers.

Drugs for Chickenpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
6
Ethanol Approved Phase 4 64-17-5 702
7
Budesonide Approved Phase 4 51333-22-3 63006 5281004
8
Interferon beta-1b Approved Phase 4 145155-23-3
9
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
10
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
11
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
12
Racepinephrine Approved Phase 4 329-65-7 838
13
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
14
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
15
Adalimumab Approved Phase 4 331731-18-1 16219006
16
Certolizumab pegol Approved Phase 4 428863-50-7
17
Mercaptopurine Approved Phase 4 50-44-2 667490
18
Azathioprine Approved Phase 4 446-86-6 2265
19
Infliximab Approved Phase 4 170277-31-3
20
Tofacitinib Approved, Investigational Phase 4 477600-75-2
21
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
22 Hormones Phase 4
23 Hormone Antagonists Phase 4
24 glucocorticoids Phase 4
25 Methylprednisolone Acetate Phase 4
26 Antineoplastic Agents, Hormonal Phase 4
27 Vaccines Phase 4
28 Respiratory System Agents Phase 4
29 Anti-Asthmatic Agents Phase 4
30 Bronchodilator Agents Phase 4
31 Anti-Inflammatory Agents Phase 4
32 Dermatologic Agents Phase 4
33 Interferon-beta Phase 4
34 (T,G)-A-L Phase 4
35 Fingolimod Hydrochloride Phase 4
36 interferons Phase 4
37
Glatiramer Acetate Phase 4 147245-92-9 3081884
38 Anti-Allergic Agents Phase 4
39 Epinephryl borate Phase 4
40 valacyclovir Phase 4
41 Antiviral Agents Phase 4
42 Janus Kinase Inhibitors Phase 4
43 polysaccharide-K Phase 4
44 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
45 Mesalamine Phase 4 89-57-6
46
Methylene blue Approved, Investigational Phase 3 61-73-4
47
Altretamine Approved Phase 3 645-05-6 2123
48
Acyclovir Approved Phase 3 59277-89-3 2022
49
Lactitol Approved, Investigational Phase 3 585-88-6, 585-86-4 493591
50
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345

Interventional clinical trials:

(show top 50) (show all 273)
# Name Status NCT ID Phase Drugs
1 A Study of Immune Persistence After Inoculated With One-dose Freeze-dried Live Attenuated Varicella Vaccine in Children Aged 1-6 Years Unknown status NCT01982409 Phase 4
2 Study on Effectiveness of 2-dose Live Attenuated Varicella Vaccine Unknown status NCT02146469 Phase 4
3 Phase 4 Study of the Varicella Vaccine After the 2nd Dose Vaccination Unknown status NCT01830283 Phase 4
4 Phase 4 Study of Live Attenuated Varicella Vaccine After the 2 Doses Vaccination Unknown status NCT01866566 Phase 4
5 Safety and Immunogenicity of Live Attenuated Herpes Zoster Vaccine in Patients Undergoing Living Donor Kidney Transplantations Unknown status NCT00940940 Phase 4
6 A Pilot Study to Characterize the Immune Response Induced by a Commercial Varicella Zoster Virus Vaccine in Healthy Adult Females in Nairobi, Kenya. Unknown status NCT02514018 Phase 4
7 Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children Unknown status NCT00494624 Phase 4 prednisolone
8 A Study to Evaluate the Immunogenicity and Safety of 2 Doses of Live Attenuated Varicella Vaccine Completed NCT01817270 Phase 4
9 Rates of Seroconversion Following Varicella Vaccination of Asthmatic Children Between the Ages of One and Eight Years Treated With Pulmicort Respules® Versus Non-Steroidal Conventional Asthma Therapy Completed NCT00641446 Phase 4 budesonide;varicella zoster virus
10 A Study to Evaluate the Immunogenicity and Safety of 2 Doses of Live Attenuated Varicella Vaccine Completed NCT02173899 Phase 4
11 Blinded, Randomised Study to Assess the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Live Attenuated Measles-mumps-rubella-varicella Candidate Vaccine When Given to Healthy Children in Their Second Year of Life Completed NCT00126997 Phase 4
12 A Study to Evaluate the Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Live Attenuated JE Vaccine Completed NCT01815073 Phase 4
13 Safety of a Second Dose of Biken's Varicella Vaccine Administered at 4 to 6 Years of Age in Healthy Children in Argentina Completed NCT00830648 Phase 4
14 A Double-blind, Randomised, Controlled, Multi-centre Safety Study of a Refrigerator-stable Formulation of VARIVAX® in Healthy 12 to 15 Month-old Infants. Completed NCT00432731 Phase 4
15 Evaluation of Safety and Immunogenicity Receiving Live Attenuated Vaccine Against Varicella Without Gelatin Completed NCT01684072 Phase 4
16 An Open, Multicenter Study of the Safety and Tolerability of VAQTA(TM) and ProQuad(TM) in Healthy Children 12 to 23 Months of Age Completed NCT00326183 Phase 4
17 Live Attenuated Varicella Vaccine: A New Effective Adjuvant Weapon in the Battlefield Against Severe Resistant Psoriasis, a Randomized Controlled Trial Completed NCT01356004 Phase 4 live attenuated chicken pox vaccine;saline, efficacy
18 The Immunogenicity of Varicella-zoster Virus Vaccine in HIV-infected Children Completed NCT01138215 Phase 4
19 T Cell Responses to Varicella Zoster Virus After Vaccination and Viral Escape Completed NCT01911065 Phase 4
20 Immunogenicity and Safety of a Herpes Zoster Vaccine (Zostavax) in Patients With Systemic Lupus Erythematosus: a Randomized Controlled Trial Completed NCT02477150 Phase 4
21 An Open, Randomized, Multicenter Study of the Safety, Tolerability, & Immunogenicity of VAQTAâ„¢ Given Concomitantly With PROQUADâ„¢ and PREVNARâ„¢ in Healthy Children 12 Months of Age Completed NCT00312858 Phase 4
22 An Open-label, Single-arm, Phase IV Study Assessing the Immunogenicity and Safety of ZOSTAVAX® at Minimum Release Specification Approaching Expiry Potency in Subjects ≥50 Years Old. Completed NCT00681031 Phase 4
23 Palatability Testing of a New Paediatric Formulation of Valacyclovir for the Prophylaxis and Treatment of VZV and HSV Infections in Children Completed NCT01682109 Phase 4 Valacyclovir
24 Immune Response to Shingles Vaccination Completed NCT02624375 Phase 4 Zoster Vaccine Live
25 Effectiveness Assessment of Vaccinating Schoolchildren Against Influenza the in São Paulo, 2009 Completed NCT01693380 Phase 4
26 Placebo Controlled Evaluation of the Cell Mediated Immune Response of Cirrhotic Subjects to Zostavaxâ„¢ Completed NCT02958345 Phase 4
27 Immunogenicity and Safety of a Tetanus-diphtheria Vaccine and a 13-valent Pneumococcal Conjugate Vaccine After Concomitant Vaccination in ≥50-year-old Adults Completed NCT03552445 Phase 4
28 A 12-month, Prospective, Randomized, Active-controlled, Open-label Study to Evaluate the Patient Retention of Fingolimod vs. Approved First-line Disease Modifying Therapies in Adults With Relapsing Remitting Multiple Sclerosis (PREFERMS) Completed NCT01623596 Phase 4 Fingolimod;Disease Modifying therapy
29 Multicenter Randomised Controlled Trial of Episodic Fluticasone Versus Placebo in Viral-induced Asthma in Children Completed NCT00238927 Phase 4 inhaled fluticasone 750 mcg/day twice daily until 2 days without symptoms (maximum 15 consecutive days)
30 Double-Blind Placebo-Controlled Clinical Effectiveness Trial of the 23-Valent Pneumococcal Vaccine Among Military Trainees At Increased Risk of Respiratory Disease Completed NCT02079701 Phase 4
31 Occupational Exposure to Human Papilloma Virus (HPV) and Prophylactic Vaccination (Version IV Dated 24Oct2017) Recruiting NCT03350698 Phase 4
32 The Immunogenicity and Efficacy of Subunit Vaccine Against Herpes Zoster in RA Treated With JAK-inhibitors (VACCIMIL-ZOSTER) Recruiting NCT03886038 Phase 4
33 Long-term Suppressive Valacyclovir Treatment for Herpes Zoster Ophthalmicus Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
34 Safety and Immunogenicity of Recombinant Glycoprotein E Herpes Zoster Subunit (HZ/su) Vaccine in Renal Transplant Recipients Recruiting NCT03993717 Phase 4
35 Safety and Immunogenicity of Measles Vaccine, Varicella Vaccine and Hepatitis-A Vaccine in HIV-exposed and HIV-unexposed South African Children Active, not recruiting NCT03330171 Phase 4
36 Immunodeficiency in Cartilage-hair Hypoplasia: Correlation With Pulmonary Disease, Infections and Malignancy Active, not recruiting NCT02383797 Phase 4
37 Safety and Immunogenicity of Non-live, Recombinant Subunit Herpes Zoster Vaccine Before and After Lung Transplantation Active, not recruiting NCT03493776 Phase 4
38 Safety and Tolerability of Herpes Zoster Vaccine in Patients With Rheumatoid Arthritis Immunized Prior to Biologics and Tofacitinib Therapy Initiation Active, not recruiting NCT03016884 Phase 4
39 Vaccinating Children After Chemotherapy for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study Active, not recruiting NCT02447718 Phase 4
40 A Cross-over, Open-label, Single-group Study to Evaluate the Safety and Immunogenicity of Live Attenuated Varicella Vaccine Skyvaricella Injection (Inj.) Developed by SK Bioscience (Company Limited) Co., Ltd of South Korea in Healthy Volunteer Vietnamese Children From 12 Months to 12 Years Old Not yet recruiting NCT04384016 Phase 4
41 Persistence of Varicella Immunity in Hospital Employees Receiving Varicella Vaccine Not yet recruiting NCT02026089 Phase 4
42 VZV-specific Tissue Resident Memory T-cells After Shingrix Vaccination Not yet recruiting NCT04403139 Phase 4 Shingrix
43 The Immunogenicity and Safety of Shingrix Vaccine in Patients With Moderate to Severe Ulcerative Colitis on Tofacitinib Suspended NCT03591770 Phase 4
44 A Double Blind Placebo-controlled Randomized Study of Varicella Zoster Vaccine in Patients With Moderate-to-severe Plaque Psoriasis Who Are Candidates for Biologic Therapy Terminated NCT02408159 Phase 4 Varicella Zoster Vaccine;Placebo
45 Induction and Maintenance of Immunity Against Varicella in Pediatric Orthotopic Liver Transplantation Recipients: a Retrospective and Prospective Nationwide Study in Switzerland Unknown status NCT00492739 Phase 2, Phase 3
46 Serological Evaluation of Chickenpox (Varicella) and Hepatitis A Vaccines Using Disposable Needle-Free Syringe Jet Injector (DSJI) Delivery Unknown status NCT00926419 Phase 2, Phase 3
47 Safety and Immunogenicity of Live Attenuated Oka/Merck Varicella Vaccine in Children Listed to Undergo Solid Organ Transplantation Unknown status NCT00213304 Phase 3
48 A Multi-center, Randomized, Double-blinded, Phase 3 Trial to Evaluate the Efficacy Against Herpes Zoster of a Live Attenuated Varicella-Zoster Virus Vaccine in Adults Over 40 Years of Age Unknown status NCT03314103 Phase 3
49 A Comparative Study of Tzanck Smear With Methylene Blue Versus Giemsa Stain to Diagnose Herpes Simplex, Herpes Zoster and Varicella Zoster Skin Infections Unknown status NCT03178747 Phase 3
50 A Phase II/III, Single-blind(Stage 1), Double-blinded(Stage 2), Randomized, Active-controlled, Dose-escalation(Stage 1), Non-inferiority(Stage 2) Study to Evaluate Immunogenicity and Safety of MG1111 in Healthy Children Unknown status NCT03375502 Phase 2, Phase 3 Varicella Vaccine

Search NIH Clinical Center for Chickenpox

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Acyclovir
Acyclovir Sodium
Sources

Genetic Tests for Chickenpox

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Sources

Anatomical Context for Chickenpox

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The Foundational Model of Anatomy Ontology organs/tissues related to Chickenpox:

19
Skin

MalaCards organs/tissues related to Chickenpox:

40
Skin, T Cells, Testes, Bone, Bone Marrow, Liver, Kidney
Sources

Publications for Chickenpox

About this section

Articles related to Chickenpox:

(show top 50) (show all 15341)
# Title Authors PMID Year
1
Seroepidemiology of hepatitis viruses, measles, mumps, rubella and varicella among healthcare workers and students: Should we screen before vaccination? 42 61
32113699 2020
2
Risk of herpes zoster after exposure to varicella to explore the exogenous boosting hypothesis: self controlled case series study using UK electronic healthcare data. 42 61
31969318 2020
3
Herpes zoster: vaccination status and virtuous experiences. 42
32286762 2020
4
[Adenosine deaminase deficiency associated severe combined immunodeficiency with disseminated varicella infection after vaccination: a case report]. 61 54
19099832 2008
5
[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]. 61 54
12604384 2003
6
New variant of varicella-zoster virus. 54 61
12498673 2002
7
Expression of the simian varicella virus glycoprotein E. 61 54
11551643 2001
8
Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants. 61 54
10027650 1999
9
Identification of immunodominant regions and linear B cell epitopes of the gE envelope protein of varicella-zoster virus. 54 61
8553555 1995
10
Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine. 61 54
7486953 1995
11
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine. 61 54
8045919 1994
12
Susceptibility of Oka varicella vaccine strain to antiviral drugs. 54 61
8310756 1993
13
Association between climatic factors and varicella incidence in Guangzhou, Southern China, 2006-2018. 61
32330739 2020
14
Low complication rate in immunocompromised children with varicella-zoster virus infections in a single centre. 61
31785008 2020
15
Analysis of the reiteration regions (R1 to R5) of varicella-zoster virus. 61
32452416 2020
16
Epidemiology of Toscana virus in South Tuscany over the years 2011-2019. 61
32474372 2020
17
Reply to "Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients": Discussing specificity. 61
32380215 2020
18
Varicella-like exanthem as a specific COVID-19-associated skin manifestation: Multicenter case series of 22 patients. 61
32305439 2020
19
Epidemiology of herpes simplex and varicella zoster virus in cerebrospinal fluid of patients suffering from meningitis in Iran. 61
32528686 2020
20
Challenges in the Diagnosis of Medulloblastoma Recurrence at an Unusual Site in a Patient With Prader-Willi Syndrome. 61
31306337 2020
21
Non-invasive detection of IgG antibodies from common pathogenic viruses using oral flocked swabs. 61
32444155 2020
22
Oculomotor nerve palsy in herpes zoster ophthalmicus: Presentation of 4 cases. 61
32505385 2020
23
Determinants of neurological syndromes caused by varicella zoster virus (VZV). 61
32495195 2020
24
Varicella-Zoster Virus (VZV) Small Noncoding RNAs Antisense to the VZV Latency-Encoded Transcript VLT Enhance Viral Replication. 61
32295909 2020
25
Viral ribonucleotide reductase attenuates the anti-herpes activity of acyclovir in contrast to amenamevir. 61
32569704 2020
26
A Varicella Case After Herpes-Zoster Vaccination in a Patient Treated With a Tumor Necrosis Factor Inhibitor. 61
32501941 2020
27
Evaluation of glycoprotein E subunit and live attenuated varicella-zoster virus vaccines formulated with a single-strand RNA-based adjuvant. 61
32167678 2020
28
Detection of herpes simplex and varicella-zoster virus from skin lesions: comparison of RT-PCR and isothermal amplification for rapid identification. 61
32088016 2020
29
Herpesvirus Infections Potentiated by Biologics. 61
32444012 2020
30
Hypertrophic genital herpes in an HIV-infected female patient: Imiquimod as an alternative treatment. 61
32311452 2020
31
Causes and Clinical Features of Childhood Encephalitis: A Multicenter, Prospective Cohort Study. 61
31549170 2020
32
Cerebrospinal fluid biomarkers in patients with central nervous system infections: a retrospective study. 61
31130152 2020
33
Acute myocarditis following varicella zoster infection in an immunocompetent adolescent: An uncommon complication. 61
32470266 2020
34
Clinical utility of aqueous humor polymerase chain reaction and serologic testing for suspected infectious uveitis: a single-center retrospective study in South Korea. 61
32560636 2020
35
Varicella and herpes zoster appearing over sites of tinea corporis, hitherto unreported examples of immunocompromised districts: a case series. 61
32072634 2020
36
Intravenous Vitamin C as Ancillary Treatment for Cranial Polyneuritis and Meningitis due to Varicella Zoster Virus Reactivation. 61
32577025 2020
37
[Five cases of optic neuropathy associated with varicella zoster virus infection]. 61
32536128 2020
38
[Successful early treatment with acyclovir and corticosteroids for acute myelitis associated with zoster sine herpete: a case report]. 61
32536667 2020
39
Clinical features of aseptic meningitis with varicella zoster virus infection diagnosed by next-generation sequencing: case reports. 61
32571239 2020
40
Varicella infection following vaccination in a pediatric kidney transplant recipient. 61
32068320 2020
41
Oral mucosa lesions in COVID-19. 61
32558983 2020
42
Psoriasis and risk of the COVID-19 infection: Is there a role for Angiotensin Converting Enzyme (ACE)? 61
32543296 2020
43
Histopathological Study of a Broad Spectrum of Skin Dermatoses in Patients Affected or Highly Suspected of Infection by COVID-19 in the Northern Part of Italy: Analysis of the Many Faces of the Viral-Induced Skin Diseases in Previous and New Reported Cases. 61
32576730 2020
44
Polyneuritis cranialis and vasculopathy caused by varicella zoster virus without rash. 61
32524536 2020
45
Histology of skin lesions establishes that the vesicular rash associated with COVID-19 is not "varicella-like". 61
32500642 2020
46
A Bilateral Lumbar Multidermatomal Herpes Zoster in an Elderly Woman with Chronic Kidney Disease. 61
32514691 2020
47
Herpes Zoster (shingles) complicating the course of COVID19 infection. 61
32543328 2020
48
Attitudes towards varicella vaccination in parents and paediatric healthcare providers in Hungary. 61
32546413 2020
49
Persistence of Varicella-Zoster Virus-Specific Plasma Cells in Adult Human Bone Marrow following Childhood Vaccination. 61
32321817 2020
50
Binding varicella zoster virus: an underestimated facet of insulin-degrading enzyme´s implication for Alzheimer´s disease pathology? 61
30806771 2020
Sources

Variations for Chickenpox

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Expression for Chickenpox

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Search GEO for disease gene expression data for Chickenpox.
Sources

Pathways for Chickenpox

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Pathways related to Chickenpox according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.97 TNF MUC1 IL6 IL2 IFNG IFNB1
2
PEDF Induced Signaling 63
Show member pathways
 13.67 TNF IL6 IL2 IFNG IFNB1 IFNA1
3
PAK Pathway 63
Show member pathways
 13.31 TNF IL6 IL2 CD40LG CD4 CD27
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.3 TNF MUC1 IL6 IL2 IFNG IFNB1
5
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.07 TNF IL6 IL2 IFNG IFNB1 IFNA1
6
PI3K-Akt signaling pathway 36
Show member pathways
 13.01 TNF IL6 IL2 IFNB1 IFNA1 CD19
7
Herpes simplex virus 1 infection 36
12.8 TNF IL6 IFNG IFNB1 IFNA1
8
Measles 36
Show member pathways
 12.8 TNF IL6 IL2 IFNG IFNB1 IFNA1
9
Allograft rejection 1 36
Show member pathways
 12.78 TNF IL6 IL2 IFNG IFNA1 CD8A
10
4-1BB Pathway 63
Show member pathways
 12.68 TNF IFNG CD40LG CD4 CD27
11
Immune response NFAT in immune response 22
Show member pathways
 12.65 TNF IL2 IFNG CD40LG CD4
12
Th17 cell differentiation 36
Show member pathways
 12.6 TNF IL6 IL2 IFNG CD4
13
Immune response IL-23 signaling pathway 22
Show member pathways
 12.6 TNF IL6 IL2 IFNG CD4
14
T cell receptor signaling pathway 36
Show member pathways
 12.56 TNF IL6 IL2 IFNG CD8A CD40LG
15
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.53 TNF IL2 IFNG IFNB1 IFNA1
16
NF-kappaB Signaling 4
12.52 TNF IL2 IFNG IFNA1 CD8A CD40LG
17
JAK-STAT signaling pathway 36
Show member pathways
 12.47 IL6 IL2 IFNG IFNB1 IFNA1
18
Human T-cell leukemia virus 1 infection 36
12.35 TNF IL6 IL2 CD4
19
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.34 TNF IL6 IL2 CCR6
20
Folate Metabolism 1
Show member pathways
 12.34 TNF IL6 IL2 IFNG CRP
21
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.27 TNF IL6 IL2 IFNG IFNB1 IFNA1
22
NOD-like receptor signaling pathway 36
12.25 TNF IL6 IFNB1 IFNA1
23
Tuberculosis 36
12.24 TNF IL6 IFNG IFNB1 IFNA1
24
Necroptosis 36
Show member pathways
 12.22 TNF IFNG IFNB1 IFNA1
25
Bacterial infections in CF airways 22
Show member pathways
 12.19 TNF MUC1 IL6 IFNG IFNB1
26
Yersinia infection 36
12.02 TNF IL6 IL2 IFNB1
27
Spinal Cord Injury 1
12.02 TNF IL6 IL2 IFNG
28
IL12-mediated signaling events 1
Show member pathways
 11.99 IL2 IFNG CD8A CD4
29
IL27-mediated signaling events 1
Show member pathways
 11.95 TNF IL6 IL2 IFNG CD4
30
Hematopoietic cell lineage 36
11.9 TNF IL6 CD8A CD4 CD19
31
Interferon Pathway 63
11.88 IL6 IFNG IFNB1 IFNA1
32
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.78 TNF IL2 IFNG CD40LG
33
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.76 TNF IL6 IL2 IFNG CD8A CD4
34
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.65 TNF IL2 IFNG CD8A
35
Innate Lymphoid Cells Differentiation 64
11.64 TNF IL2 IFNG CD8A CD4 CCR6
36
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 TNF IL6 IL2 IFNG CD40LG
37
Photodynamic therapy-induced AP-1 survival signaling. 1
11.57 TNF IL6 IL2 IFNG
38
Aryl Hydrocarbon Receptor Pathway 1
11.54 TNF IL2 IFNG
39
all-trans-Retinoic Acid Mediated Apoptosis 63
11.53 IL6 IFNB1 IFNA1
40
Th2 Differentiation 64
11.52 IL2 IFNG CD4
41
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.51 TNF IL6 IFNG
42
Malaria 36
11.47 TNF IL6 IFNG GYPC CD40LG
43
African trypanosomiasis 36
11.41 TNF IL6 IFNG
44
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.39 TNF IL2 IFNG
45
Inflammatory Response Pathway 1
11.35 IL2 IFNG CD40LG
46
Development and heterogeneity of the ILC family 1
11.33 TNF IL6 IFNG
47
Primary immunodeficiency 36
11.3 CD8A CD40LG CD4 CD19 ADA
48
IL12 signaling mediated by STAT4 1
11.25 IL2 IFNG CD4
49
Dendritic Cells Developmental Lineage Pathway 64
11.09 TNF IL6 IL2 IFNG IFNB1 CD8A
50
Overview of nanoparticle effects 1
11.06 TNF IL6 CRP
Sources

GO Terms for Chickenpox

About this section

Cellular components related to Chickenpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 TNF MUC1 IL6 IL2 IFNG IFNB1
2 integral component of plasma membrane GO:0005887 9.81 TNF MUC1 GYPC CD8A CD40LG CD4
3 cell surface GO:0009986 9.8 TNF CD40LG CD4 CD27 CCR6 ADA
4 extracellular space GO:0005615 9.73 TNF MUC1 MIR122 IL6 IL2 IFNG
5 external side of plasma membrane GO:0009897 9.23 TNF CD8A CD40LG CD4 CD27 CD19

Biological processes related to Chickenpox according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.02 TNF IL6 IFNG CRP ACTC1
2 negative regulation of apoptotic process GO:0043066 9.99 IL6 IL2 CD40LG CD27 ADA ACTC1
3 cell surface receptor signaling pathway GO:0007166 9.95 IFNG IFNB1 CD8A CD4 CD27
4 defense response to virus GO:0051607 9.89 IL6 IFNG IFNB1 IFNA1
5 positive regulation of protein phosphorylation GO:0001934 9.88 TNF IL2 IFNG CD4
6 B cell differentiation GO:0030183 9.8 IFNB1 IFNA1 CD40LG
7 adaptive immune response GO:0002250 9.8 IL2 IFNG IFNB1 IFNA1 CD8A CD4
8 immune response GO:0006955 9.76 TNF IL6 IL2 IFNG CD8A CD40LG
9 T cell activation GO:0042110 9.75 CD8A CD4 ADA
10 extrinsic apoptotic signaling pathway GO:0097191 9.73 TNF IFNG CD27
11 B cell proliferation GO:0042100 9.71 IFNB1 IFNA1 CD40LG
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TNF IL6 IL2 IFNG
13 positive regulation of T cell proliferation GO:0042102 9.67 IL6 IL2 CD40LG CD4
14 positive regulation of T cell differentiation GO:0045582 9.63 IL2 CD27 ADA
15 negative regulation of amyloid-beta clearance GO:1900222 9.61 TNF IFNG
16 negative regulation of T cell apoptotic process GO:0070233 9.61 DOCK8 CD27
17 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.61 IFNG IFNB1 IFNA1
18 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.6 TNF IFNG
19 regulation of immunoglobulin secretion GO:0051023 9.57 TNF CD40LG
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 TNF IFNG
21 negative regulation of lipid storage GO:0010888 9.5 TNF IL6 CRP
22 cytokine-mediated signaling pathway GO:0019221 9.5 TNF MUC1 IL6 IL2 IFNB1 IFNA1
23 positive regulation of vitamin D biosynthetic process GO:0060557 9.49 TNF IFNG
24 positive regulation of nitrogen compound metabolic process GO:0051173 9.48 TNF IFNG
25 humoral immune response GO:0006959 9.1 TNF IL6 IFNG IFNB1 IFNA1 CCR6

Molecular functions related to Chickenpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 TNF IL6 IL2 IFNG IFNB1 IFNA1
Sources

Sources for Chickenpox

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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