MCID: CHF001
MIFTS: 22

Chief Cell Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Chief Cell Adenoma

MalaCards integrated aliases for Chief Cell Adenoma:

Name: Chief Cell Adenoma 12 15 71
Chief Cell Adenoma of Parathyroid Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7607
NCIt 49 C4154
SNOMED-CT 67 12205003
UMLS 71 C0334320

Summaries for Chief Cell Adenoma

MalaCards based summary : Chief Cell Adenoma, also known as chief cell adenoma of parathyroid gland, is related to adenoma and hyperparathyroidism. An important gene associated with Chief Cell Adenoma is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Collagen chain trimerization and Surfactant metabolism. Affiliated tissues include bone, breast and pituitary.

Related Diseases for Chief Cell Adenoma

Diseases related to Chief Cell Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adenoma 10.1
2 hyperparathyroidism 9.9
3 hypopituitarism 9.9
4 macular degeneration, age-related, 10 9.9 PGA4 PGA3
5 leukodystrophy, hypomyelinating, 6 9.7 UHRF1BP1L SNAP23
6 atrophic gastritis 9.6 PGA5 PGA4 PGA3
7 gastritis 9.6 PGA5 PGA4 PGA3

Graphical network of the top 20 diseases related to Chief Cell Adenoma:



Diseases related to Chief Cell Adenoma

Symptoms & Phenotypes for Chief Cell Adenoma

Drugs & Therapeutics for Chief Cell Adenoma

Search Clinical Trials , NIH Clinical Center for Chief Cell Adenoma

Genetic Tests for Chief Cell Adenoma

Anatomical Context for Chief Cell Adenoma

MalaCards organs/tissues related to Chief Cell Adenoma:

40
Bone, Breast, Pituitary

Publications for Chief Cell Adenoma

Articles related to Chief Cell Adenoma:

(show all 26)
# Title Authors PMID Year
1
Molecular profiles of oxyphilic and chief cell parathyroid adenoma. 61
28986304 2018
2
Raman Spectroscopy Applied to Parathyroid Tissues: A New Diagnostic Tool to Discriminate Normal Tissue from Adenoma. 61
29227640 2018
3
Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia. 61
29296592 2017
4
Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue. 61
18457912 2008
5
Parathyroid chief cell adenoma associated with massive chronic parathyroiditis in a woman with hyperparathyroidism. 61
17652800 2007
6
Brown tumors mimicking bone metastases. 61
16775919 2006
7
Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. 61
15168774 2004
8
Cox-2 expression in the oxyphilic cells of the normal, hyperplastic, and adenomatous parathyroid gland. 61
15067174 2004
9
Metachronous double parathyroid adenomas involving two different cell types: chief cell and oxyphil cell. 61
14715480 2003
10
[Large parathyroid adenoma in a 38-year old woman with primary hyperparathyroidism]. 61
10994383 2000
11
Familial hyperparathyroidism: report of a case. 61
9934834 1999
12
Hypocalcemia due to spontaneous infarction of parathyroid adenoma and osteomalacia in a patient with primary hyperparathyroidism. 61
10395241 1998
13
Remission of non-insulin-dependent diabetes mellitus following resection of a parathyroid adenoma. 61
9017358 1997
14
Endocrine neoplasia in New World primates. 61
8740950 1996
15
Positron emission tomography with 11C-methionine in hyperparathyroidism. 61
7985105 1994
16
A patient with primary hyperparathyroidism associated with osteomalacia: markedly increased serum levels of intact PTH and 1,25-dihydroxyvitamin D with normo- and hypercalcemia. 61
7951485 1993
17
Cell kinetics in parathyroid adenomas: evidence for decline in rates of cell birth and tumour growth, assuming clonal origin. 61
1934531 1991
18
[A parathyroid cyst and an adenoma associated with primary hyperparathyroidism: report of a case]. 61
2264548 1990
19
Localization of mediastinal parathyroid adenoma by T1-201 scintiscan and SPECT. 61
2355726 1990
20
[Primary hyperparathyroidism in a child with parathyroid crisis--review of 24 cases reported in Japan]. 61
2660505 1989
21
[Multiple hypersecreting lesions of the parathyroid glands during treatment with lithium]. 61
3717817 1986
22
Primary hyperparathyroidism and rickets. A case report and review of the literature. 61
6549555 1984
23
Primary hyperparathyroidism in children. 61
7055756 1982
24
[Calcium induced necroses of cardiac muscle causing death in acute hyperparathyroidism (author's transl)]. 61
7353514 1980
25
Centriolar abnormalities in human neoplasms. 61
579445 1977
26
[Dissociated anterior pituitary insufficiency after surgery of chief cell adenoma]. 61
13512256 1957

Variations for Chief Cell Adenoma

Expression for Chief Cell Adenoma

Search GEO for disease gene expression data for Chief Cell Adenoma.

Pathways for Chief Cell Adenoma

GO Terms for Chief Cell Adenoma

Cellular components related to Chief Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multivesicular body lumen GO:0097486 8.8 PGA5 PGA4 PGA3

Biological processes related to Chief Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.33 PGA5 PGA4 PGA3
2 protein catabolic process GO:0030163 9.13 PGA5 PGA4 PGA3
3 digestion GO:0007586 8.8 PGA5 PGA4 PGA3

Molecular functions related to Chief Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.13 PGA5 PGA4 PGA3
2 aspartic-type endopeptidase activity GO:0004190 8.8 PGA5 PGA4 PGA3

Sources for Chief Cell Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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