MCID: CHK001
MIFTS: 59

Chikungunya

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Chikungunya

MalaCards integrated aliases for Chikungunya:

Name: Chikungunya 12 76 53 59 43 15
Chikungunya Fever 12 53 3 73
Ck 53 3
Arbovirus a Chikungunya Type 53
Chikungunya Virus Infection 53
Chikv Infection 53
Chik 53

Characteristics:

Orphanet epidemiological data:

59
chikungunya
Prevalence: <1/1000000 (France),<1/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050012
Orphanet 59 ORPHA324625
UMLS via Orphanet 74 C0008055
ICD10 via Orphanet 34 A92.0
ICD10 33 A92.0
UMLS 73 C0008055

Summaries for Chikungunya

MedlinePlus : 43 Chikungunya is a virus that spread by the same kinds of mosquitoes that spread dengue and Zika virus. Rarely, it can spread from mother to newborn around the time of birth. It may also possibly spread through infected blood. There have been outbreaks of chikungunya virus in Africa, Asia, Europe, the Indian and Pacific Oceans, the Caribbean, and Central and South America. Most people who are infected will have symptoms, which can be severe. They usually start 3-7 days after being bitten by an infected mosquito. The most common symptoms are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, and rash. Most people feel better within a week. In some cases, however, the joint pain may last for months. People at risk for more severe disease include newborns, older adults, and people with diseases such as high blood pressure, diabetes, or heart disease. A blood test can show whether you have chikungunya virus. There are no vaccines or medicines to treat it. Drinking lots of fluids, resting, and taking non-aspirin pain relievers might help. The best way to prevent chikungunya infection is to avoid mosquito bites: Use insect repellent Wear clothes that cover your arms, legs, and feet Stay in places that have air conditioning or that use window and door screens Centers for Disease Control and Prevention

MalaCards based summary : Chikungunya, also known as chikungunya fever, is related to dengue virus and anterior uveitis, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is OAS3 (2'-5'-Oligoadenylate Synthetase 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs chloroquine and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and heart, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A viral infectious disease that results in infection located in joint, has material basis in Chikungunya virus, which is transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

CDC : 3 Get Email Updates

Wikipedia : 76 Chikungunya is an infection caused by the chikungunya virus (CHIKV). Symptoms include fever and joint... more...

Related Diseases for Chikungunya

Diseases related to Chikungunya via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 dengue virus 32.6 DDX58 OAS3 RSAD2
2 anterior uveitis 30.3 CCL2 IL6
3 kawasaki disease 29.9 CCL2 IL6 TNF
4 exanthem 29.8 CD40LG IL6 TNF
5 arthritis 29.8 CCL2 IL1B IL6 TNF
6 myocarditis 29.7 CD40LG IL6 TNF
7 stomatitis 29.7 BST2 DDX58 RSAD2
8 hemorrhagic fever 29.6 CD40LG IL6 TNF
9 japanese encephalitis 29.6 CCL5 DDX58 TNF
10 measles 29.5 CD40LG DDX58 IL6
11 hepatitis e 29.3 CD40LG DDX58 TNF
12 meningoencephalitis 29.3 CCL5 CD40LG IL6
13 rheumatic disease 29.2 CD40LG IL1B TNF
14 neuritis 28.8 CCL2 CCL5 IL1B TNF
15 encephalitis 28.7 CCL2 CCL5 DDX58 IL1B RSAD2
16 leptospirosis 28.2 CCL2 CD40LG IL1B IL6 TNF
17 myocardial infarction 28.2 CCL2 CCL5 CD40LG IL1B IL6 TNF
18 systemic lupus erythematosus 28.0 CCL2 CCL5 CD40LG IL6 TNF
19 malaria 27.6 CCL2 CCL5 CD40LG IL1B IL6 TNF
20 rheumatoid arthritis 27.5 CCL2 CCL5 CD40LG IL1B IL6 TNF
21 psoriasis 27.2 CCL2 CCL5 DDX58 IL1B IL6 TNF
22 asthma 27.0 CCL2 CCL5 CD40LG IL1B IL6 TNF
23 ck syndrome 12.5
24 necrotizing autoimmune myopathy 11.1
25 isolated hyperckemia 10.9
26 chylomicron retention disease 10.9
27 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 10.9
28 hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency 10.9
29 myopathy, vacuolar, with casq1 aggregates 10.9
30 phosphoglycerate mutase deficiency 10.9
31 welander distal myopathy, swedish type 10.9
32 west nile encephalitis 10.7 BST2 OAS3
33 leukomalacia 10.7 IL6 TNF
34 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL6 TNF
35 critical limb ischemia 10.6 IL6 TNF
36 streptococcal toxic-shock syndrome 10.6 IL6 TNF
37 null-cell leukemia 10.6 IL6 TNF
38 denture stomatitis 10.6 CCL2 IL6
39 retinitis pigmentosa 55 10.6 IL6 TNF
40 anthracosis 10.6 CCL2 TNF
41 anca-associated vasculitis 10.5 IL6 TNF
42 obesity-hypoventilation syndrome 10.5 CCL5 IL6
43 scleritis 10.4 CCL2 TNF
44 stromal keratitis 10.4 CCL2 IL6 TNF
45 recurrent corneal erosion 10.4 IL1B IL6
46 polyclonal hypergammaglobulinemia 10.4 CD40LG IL6
47 bagassosis 10.4 IL1B IL6
48 trench fever 10.4 CD40LG TNF
49 encephalitozoonosis 10.4 CD40LG TNF
50 rheumatoid lung disease 10.4 CD40LG TNF

Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to Chikungunya

Symptoms & Phenotypes for Chikungunya

Symptoms:

12
  • fever
  • arthralgia
  • maculopapular rash

UMLS symptoms related to Chikungunya:


fever, pruritus

MGI Mouse Phenotypes related to Chikungunya:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 TNF CCL5 CD40LG DDX58 IL1B IL6
2 homeostasis/metabolism MP:0005376 9.65 TNF CD40LG DDX58 IL1B IL6 MAVS
3 immune system MP:0005387 9.36 CCL5 CD40LG DDX58 IL1B IL6 MAVS

Drugs & Therapeutics for Chikungunya

Drugs for Chikungunya (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
2 Anti-Inflammatory Agents Phase 3,Not Applicable
3 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Not Applicable
4 Antirheumatic Agents Phase 3,Not Applicable
5 Analgesics Phase 3
6 Analgesics, Non-Narcotic Phase 3
7 Anthelmintics Phase 3
8 Anti-Infective Agents Phase 3
9 Antimalarials Phase 3
10 Antiparasitic Agents Phase 3
11 Antiprotozoal Agents Phase 3
12 Chloroquine diphosphate Phase 3 50-63-5
13 Peripheral Nervous System Agents Phase 3
14 Antibodies Phase 1, Phase 2,Phase 2
15 gamma-Globulins Phase 1, Phase 2
16 Immunoglobulins Phase 1, Phase 2,Phase 2
17 Immunoglobulins, Intravenous Phase 1, Phase 2
18 Rho(D) Immune Globulin Phase 1, Phase 2
19 Pharmaceutical Solutions Phase 2
20 Vaccines Phase 2,Phase 1
21
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
22
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
23
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
24
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
25
Methotrexate Approved Not Applicable 1959-05-2, 59-05-2 126941
26
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
27
Pantoprazole Approved Not Applicable 102625-70-7 4679
28
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
29
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
30
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
31 Antimetabolites Not Applicable
32 Antimetabolites, Antineoplastic Not Applicable
33 Dermatologic Agents Not Applicable
34 Folic Acid Antagonists Not Applicable
35 Immunosuppressive Agents Not Applicable
36 Methylprednisolone acetate Not Applicable
37 Methylprednisolone Hemisuccinate Not Applicable
38 Nucleic Acid Synthesis Inhibitors Not Applicable
39 Prednisolone acetate Not Applicable
40 Prednisolone hemisuccinate Not Applicable
41 Prednisolone phosphate Not Applicable
42 Vitamin B Complex Not Applicable
43 Folate Nutraceutical Not Applicable
44 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 CuraChik : A Trial of the Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya Disease Terminated NCT00391313 Phase 3 Chloroquine
3 Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous Immunoglobulins Unknown status NCT02230163 Phase 1, Phase 2
4 Phase II Study to Evaluate Safety and Immunogenicity of a Chikungunya Vaccine Completed NCT02861586 Phase 2
5 Study of a Live Attenuated Chikungunya Vaccine in a Previously Epidemic Area Active, not recruiting NCT03101111 Phase 2
6 Trial of a Chikungunya Vaccine, PXVX0317 CHIKV-VLP, in Healthy Adults Active, not recruiting NCT03483961 Phase 2
7 Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults Active, not recruiting NCT02562482 Phase 2
8 Chikungunya Virus Vaccine Trial in Healthy Adults Completed NCT01489358 Phase 1
9 Study to Assess the Safety and Immunogenicity of a Chikungunya Virus Vaccine Candidate (VLA1553) in Healthy Volunteers Recruiting NCT03382964 Phase 1
10 Safety, Tolerability, and Immunogenicity of VAL-181388 in Healthy Subjects Recruiting NCT03325075 Phase 1
11 Phase I Trial of Measles Vectored Chikungungya Vaccine Active, not recruiting NCT03028441 Phase 1
12 Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya Unknown status NCT02281123
13 Chikungunya Arthritis in the Americas Completed NCT02463968
14 Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV Infection Completed NCT02553369
15 Effects of Auriculotherapy on Pain and Functional Capacity of Individuals With Chikungunya Fever Completed NCT03090685 Not Applicable
16 tDCS and Its Therapeutic Effects in CK Fever Completed NCT02993952 Not Applicable
17 A Prospective, Open Label, Treatment Use Study of Patient Safety Following Transfusion of INTERCEPT Platelet Components Completed NCT02305732
18 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
19 Zika and Microcephaly: Case-control Study Completed NCT02741882
20 Pilot Survey of Dengue Fever in Solomon Islands Completed NCT01868399
21 Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of Congo Completed NCT02656862
22 Effectiveness of and Satisfaction With a Pharmacist-managed Travel Medicine Clinic Completed NCT02625129
23 The Pilot Study of Chikungunya Virus Infections in Southern Taiwan Recruiting NCT02174341
24 Impact of the Chikungunya Outbreak in Reunion Island on the Quality of Life After 10 Years Recruiting NCT02901509
25 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico Recruiting NCT02831699
26 Sero-epidemiology of Priority Arboviruses in French Guiana Recruiting NCT03210363 Not Applicable
27 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
28 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Recruiting NCT02794181
29 Applying Wolbachia to Eliminate Dengue Recruiting NCT03055585 Not Applicable
30 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
31 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Recruiting NCT03106714
32 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Recruiting NCT03078894
33 Non Randomized Comparative Study With Control Recruiting NCT03294824
34 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
35 Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children Recruiting NCT03534245
36 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444 Not Applicable
37 ZIKAlliance Pregnant Women Cohort Recruiting NCT03188731
38 Efficacy of Starting Methotrexate Early in Chikungunya Arthritis Active, not recruiting NCT03058471 Not Applicable Methotrexate;NSAID;Steroids
39 Spatial Repellents for Arbovirus Control Enrolling by invitation NCT03553277 Not Applicable
40 World Mosquito Program Noumea - Human Sample Component Not yet recruiting NCT03552094
41 ZIKAlliance Natural History Study Not yet recruiting NCT03204409
42 RT-PCR on Urine Samples: Added Value for the Diagnosis of Chikungunya Virus Infection Suspended NCT02714985

Search NIH Clinical Center for Chikungunya

Genetic Tests for Chikungunya

Anatomical Context for Chikungunya

The Foundational Model of Anatomy Ontology organs/tissues related to Chikungunya:

19
Joint

MalaCards organs/tissues related to Chikungunya:

41
Testes, Heart, Monocytes, T Cells, Bone, Brain, Salivary Gland

Publications for Chikungunya

Articles related to Chikungunya:

(show top 50) (show all 738)
# Title Authors Year
1
Limited Evidence for Infection of Urban and Peri-urban Nonhuman Primates with Zika and Chikungunya Viruses in Brazil. ( 29404420 )
2018
2
Encephalitis and transverse myelitis in dengue and chikungunya coinfection. ( 29972580 )
2018
3
Adult-Onset Still Disease and Macrophage Activation Syndrome Following Chikungunya and Hepatitis E Coinfection. ( 29485548 )
2018
4
Complete Genome Sequences of Two Chikungunya Viruses Imported into China. ( 29954886 )
2018
5
Co-circulation and simultaneous co-infection of dengue, chikungunya, and zika viruses in patients with febrile syndrome at the Colombian-Venezuelan border. ( 29382300 )
2018
6
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. ( 29432457 )
2018
7
Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity. ( 29382880 )
2018
8
Emergence and treatment of chikungunya arthritis. ( 29389830 )
2018
9
Patterns of occurrence of Dengue and Chikungunya, and spatial distribution of mosquito vector Aedes albopictus in Swabi district, Pakistan. ( 29956428 )
2018
10
Evaluation of Aedes aegypti (Diptera: Culicidae) Life Table Attributes Upon Chikungunya Virus Replication Reveals Impact on Egg-Laying Pathways. ( 29931258 )
2018
11
Hematologic Parameters and Viral Status for Zika, Chikungunya, Bluetongue, and Epizootic Hemorrhagic Disease in White-tailed Deer ( Odocoileus virginianus) on St John, US Virgin Islands. ( 29792759 )
2018
12
Delayed central nervous system manifestation of Chikungunya virus with magnetic resonance T2 weighted imaging high signal changes-a case report. ( 29942482 )
2018
13
An Assessment of Household and Individual-Level Mosquito Prevention Methods during the Chikungunya Virus Outbreak in the United States Virgin Islands, 2014-2015. ( 29405105 )
2018
14
A summary of the imported cases of Chikungunya fever in Japan from 2006 to June 2016. ( 29394382 )
2018
15
Evidence of previous but not current transmission of chikungunya virus in southern and central Vietnam: Results from a systematic review and a seroprevalence study in four locations. ( 29425199 )
2018
16
Acute inflammatory arthritis: Methotrexate for chronic chikungunya arthritis? ( 29416137 )
2018
17
Chikungunya in U.S. Travelers: A Double Challenge. ( 29978782 )
2018
18
Competitive suppression of dengue virus replication occurs in chikungunya and dengue co-infected Mexican infants. ( 29970133 )
2018
19
Chikungunya virus evolution following a large 3'UTR deletion results in host-specific molecular changes in protein-coding regions. ( 29942653 )
2018
20
Chikungunya Virus Interacts with Heat Shock Cognate 70 Protein to Facilitate Its Entry into Mosquito Cell Line. ( 29953983 )
2018
21
Chikungunya virus infection, immunosuppression and respiratory tract infections: are they associated? ( 29939393 )
2018
22
Comparison of chikungunya viruses generated using infectious clone or the Infectious Subgenomic Amplicons (ISA) method in Aedes mosquitoes. ( 29953474 )
2018
23
Fatal Human Case of Zika and Chikungunya Virus Co-Infection with Prolonged Viremia and Viruria. ( 29933556 )
2018
24
Regulation of the chikungunya-virus-induced innate inflammatory response by protein tyrosine phosphatase non-receptor 6 in muscle cells. ( 29058147 )
2018
25
Effect of Chikungunya Virus Infection on Individuals and the Healthcare System. ( 29437205 )
2018
26
Clinical Profile, Intensive Care Unit Course, and Outcome of Patients Admitted in Intensive Care Unit with Chikungunya. ( 29422725 )
2018
27
Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones. ( 29406692 )
2018
28
Identification of Dengue and Chikungunya Cases Among Suspected Cases of Yellow Fever in the Democratic Republic of the Congo. ( 29768102 )
2018
29
Development of multiplex real time reverse transcriptase PCR assay for simultaneous detection of Zika, Dengue, Yellow Fever and Chikungunya Viruses in a single tube. ( 29979812 )
2018
30
Chikungunya: A rheumatologist's perspective. ( 29431292 )
2018
31
The Burden of Chikungunya Virus Infection: The Need for Systematic and Geriatric-Specific Epidemiological Monitoring. ( 29437206 )
2018
32
Seroprevalence of Dengue Virus, West Nile Virus, Chikungunya Virus, and Zika Virus in International Travelers Attending a Travel and Migration Center in 2015-2017, Southern Italy. ( 29683399 )
2018
33
Susceptibility of Chikungunya Virus to Inactivation by Heat and Commercially and WHO-Recommended Biocides. ( 29917109 )
2018
34
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. ( 29415070 )
2018
35
Ocular manifestations of emerging arboviruses: Dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever. ( 29929827 )
2018
36
Broad and long-lasting immune protection against various Chikungunya genotypes demonstrated by participants in a cross-sectional study in a Cambodian rural community. ( 29410416 )
2018
37
Chikungunya in Children: A Clinical Review. ( 29965820 )
2018
38
Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope. ( 29955082 )
2018
39
Zika, chikungunya and dengue: the causes and threats of new and re-emerging arboviral diseases. ( 29435366 )
2018
40
Chikungunya in Children: A Clinical Review. ( 29965819 )
2018
41
Anti-viral Activities of<i>Oroxylum indicum</i>Extracts on Chikungunya Virus Infection. ( 29434399 )
2018
42
Circulation of Chikungunya virus in Aedes aegypti in MaranhALo, Northeast Brazil. ( 29932932 )
2018
43
The MTase-like domain of chikungunya virus nsP2 inhibits the interferon response by promoting the nuclear export of STAT1. ( 29925658 )
2018
44
Case Report: An Acute Chikungunya Infection and a Recent Secondary Dengue Infection in a Peripartum Case in Ecuador. ( 29363451 )
2018
45
Chikungunya Virus-Induced Arthritis: Role of Host and Viral Factors in the Pathogenesis. ( 28910194 )
2017
46
Chikungunya Infection in Hospitalized Febrile Infants Younger Than 3 Months of Age. ( 28060043 )
2017
47
Glutathionylation of chikungunya nsP2 protein affects protease activity. ( 27984114 )
2017
48
Increased number of deaths during a chikungunya epidemic in Pernambuco, Brazil. ( 28902292 )
2017
49
Genital Aphthous Ulcers and a Case of Suspected Chikungunya: A Short Clinical Case. ( 28915309 )
2017
50
Atypical Clinical Presentations of Acute Phase Chikungunya Virus Infection in Older Adults. ( 28940357 )
2017

Variations for Chikungunya

Expression for Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for Chikungunya

Pathways related to Chikungunya according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 BST2 CCL2 CCL5 CD40LG DDX58 IL1B
2
Show member pathways
13.36 CCL2 CCL5 CD40LG IL1B IL6 TLR8
3
Show member pathways
13.23 CCL2 CCL5 CD40LG IL1B IL6 TNF
4
Show member pathways
13.01 BST2 CCL2 CCL5 CD40LG DDX58 IL1B
5
Show member pathways
12.89 CCL2 CCL5 IL1B IL6 MAVS OAS3
6
Show member pathways
12.69 CCL5 DDX58 IL1B IL6 MAVS TNF
7
Show member pathways
12.67 CD40LG IL1B IL6 TLR8 TNF
8
Show member pathways
12.57 BST2 IL1B IL6 OAS3 RSAD2 TNF
9
Show member pathways
12.53 CCL2 IL1B IL6 TNF
10
Show member pathways
12.51 DDX58 IL6 MAVS TNF
11
Show member pathways
12.48 BST2 DDX58 OAS3 RSAD2
12
Show member pathways
12.47 CD40LG IL1B TLR8 TNF
13
Show member pathways
12.39 CD40LG IL1B IL6 TNF
14
Show member pathways
12.3 CCL2 IL1B IL6 TNF
15
Show member pathways
12.3 CCL2 CCL5 DDX58 IL1B IL6 MAVS
16
Show member pathways
12.25 CCL2 CCL5 IL1B IL6 TNF
17
Show member pathways
12.23 IL1B IL6 TLR8 TNF
18
Show member pathways
12.19 IL1B IL6 TLR8 TNF
19
Show member pathways
12.15 IL1B IL6 TLR8 TNF
20 12.02 CCL2 IL1B TNF
21 12.02 DDX58 MAVS OAS3 TNF
22
Show member pathways
12.01 CCL2 CCL5 IL1B IL6
23 11.96 CCL2 IL1B IL6 TNF
24 11.93 CCL2 IL1B IL6 TNF
25 11.91 CCL2 CCL5 IL1B IL6 TNF
26 11.86 CCL2 IL1B IL6 TNF
27 11.85 IL1B IL6 TNF
28 11.84 IL1B IL6 TNF
29 11.84 CD40LG DDX58 IL1B TNF
30 11.81 CCL2 CCL5 IL1B IL6 TNF
31 11.79 CCL2 CCL5 CD40LG DDX58 IL1B MAVS
32 11.73 IL1B IL6 TNF
33 11.72 IL1B IL6 TNF
34
Show member pathways
11.61 CD40LG IL1B IL6 TNF
35 11.58 IL1B IL6 TNF
36 11.57 CCL2 CCL5 IL1B IL6 TNF
37 11.51 CCL2 IL1B TNF
38 11.47 IL1B IL6 TNF
39 11.41 CCL2 CCL5 IL1B IL6 TNF
40 11.35 IL1B IL6 TNF
41 11.34 IL1B IL6 TNF
42 11.34 CCL5 IL1B IL6
43 11.34 CCL2 CD40LG IL1B IL6 TNF
44 11.29 IL1B IL6 TNF
45 11.27 IL1B IL6 TNF
46 11.24 IL1B IL6 TNF
47 11.05 IL1B TNF
48 11.05 IL6 TNF
49 10.98 IL6 TNF
50 10.92 CCL2 IL1B TNF

GO Terms for Chikungunya

Cellular components related to Chikungunya according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CCL2 CCL5 CD40LG IL1B IL6 OAS3

Biological processes related to Chikungunya according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 DDX58 IL1B IL6 PHB TNF
2 MAPK cascade GO:0000165 9.98 CCL2 CCL5 IL1B TNF
3 cytokine-mediated signaling pathway GO:0019221 9.97 CCL2 CCL5 IL1B IL6 TNF
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL2 CCL5 PHB TNF
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 BST2 IL1B MAVS TNF
6 cellular response to lipopolysaccharide GO:0071222 9.89 CCL2 IL6 TNF
7 animal organ morphogenesis GO:0009887 9.88 CCL2 NDST1 TNF
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 CD40LG IL1B IL6 TNF
9 inflammatory response GO:0006954 9.86 CCL2 CCL5 CD40LG IL1B IL6 NDST1
10 cellular response to organic cyclic compound GO:0071407 9.84 CCL2 CCL5 IL1B TNF
11 regulation of insulin secretion GO:0050796 9.83 CCL5 IL1B TNF
12 neutrophil chemotaxis GO:0030593 9.83 CCL2 CCL5 IL1B
13 positive regulation of T cell proliferation GO:0042102 9.83 CCL5 CD40LG IL1B IL6
14 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 DDX58 IL1B IL6 MAVS TNF
15 type I interferon signaling pathway GO:0060337 9.82 BST2 OAS3 RSAD2
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 CCL5 IL6 TNF
17 humoral immune response GO:0006959 9.81 BST2 CCL2 IL6 TNF
18 positive regulation of interleukin-6 production GO:0032755 9.8 DDX58 IL1B IL6 TNF
19 protein kinase B signaling GO:0043491 9.78 CCL2 CCL5 IL1B TNF
20 monocyte chemotaxis GO:0002548 9.77 CCL2 CCL5 IL6
21 positive regulation of endothelial cell apoptotic process GO:2000353 9.71 CCL2 CD40LG
22 positive regulation of chemokine production GO:0032722 9.71 IL6 TNF
23 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CCL2 CCL5 IL1B TNF
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 IL1B TNF
26 cellular response to exogenous dsRNA GO:0071360 9.7 DDX58 MAVS
27 obsolete positive regulation of transcription factor import into nucleus GO:0042993 9.7 DDX58 MAVS
28 macrophage chemotaxis GO:0048246 9.7 CCL2 CCL5
29 defense response to virus GO:0051607 9.7 BST2 DDX58 IL6 MAVS OAS3 RSAD2
30 positive regulation of interferon-alpha production GO:0032727 9.69 DDX58 MAVS
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
32 positive regulation of tumor necrosis factor secretion GO:1904469 9.69 DDX58 MAVS
33 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 DDX58 IL1B
34 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
35 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
36 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 TLR8 TNF
37 positive regulation of interferon-alpha secretion GO:1902741 9.67 DDX58 MAVS
38 positive regulation of interleukin-8 production GO:0032757 9.67 DDX58 IL1B MAVS TNF
39 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
40 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.64 IL6 RSAD2
41 positive regulation of response to cytokine stimulus GO:0060760 9.64 DDX58 MAVS
42 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
43 positive regulation of interferon-beta secretion GO:0035549 9.62 DDX58 MAVS
44 regulation of immunoglobulin secretion GO:0051023 9.62 CD40LG TNF
45 positive regulation of interleukin-6 secretion GO:2000778 9.62 DDX58 IL1B MAVS TLR8
46 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IL1B TNF
48 response to virus GO:0009615 9.5 BST2 CCL5 DDX58 OAS3 RSAD2 TLR8
49 negative regulation of viral genome replication GO:0045071 9.1 BST2 CCL5 MAVS OAS3 RSAD2 TNF
50 immune system process GO:0002376 10.07 DDX58 MAVS OAS3 RSAD2 TLR8

Molecular functions related to Chikungunya according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.8 BST2 CCL2 CCL5 CD40LG DDX58 IL1B
2 double-stranded RNA binding GO:0003725 9.33 DDX58 OAS3 TLR8
3 cytokine activity GO:0005125 9.1 CCL2 CCL5 CD40LG IL1B IL6 TNF

Sources for Chikungunya

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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62 PubMed
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69 SNOMED-CT via HPO
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71 TGDB
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74 UMLS via Orphanet
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