CK
MCID: CHK001
MIFTS: 61

Chikungunya (CK)

Categories: Blood diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Chikungunya

MalaCards integrated aliases for Chikungunya:

Name: Chikungunya 12 77 54 60 44 15
Chikungunya Fever 12 54 74 3
Ck 54 3
Arbovirus a Chikungunya Type 54
Chikungunya Virus Infection 54
Chikv Infection 54
Chik 54

Characteristics:

Orphanet epidemiological data:

60
chikungunya
Prevalence: <1/1000000 (France),<1/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050012
ICD10 34 A92.0
ICD10 via Orphanet 35 A92.0
UMLS via Orphanet 75 C0008055
Orphanet 60 ORPHA324625
UMLS 74 C0008055

Summaries for Chikungunya

MedlinePlus : 44 Chikungunya is a virus that spread by the same kinds of mosquitoes that spread dengue and Zika virus. Rarely, it can spread from mother to newborn around the time of birth. It may also possibly spread through infected blood. There have been outbreaks of chikungunya virus in Africa, Asia, Europe, the Indian and Pacific Oceans, the Caribbean, and Central and South America. Most people who are infected will have symptoms, which can be severe. They usually start 3-7 days after being bitten by an infected mosquito. The most common symptoms are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, and rash. Most people feel better within a week. In some cases, however, the joint pain may last for months. People at risk for more severe disease include newborns, older adults, and people with diseases such as high blood pressure, diabetes, or heart disease. A blood test can show whether you have chikungunya virus. There are no vaccines or medicines to treat it. Drinking lots of fluids, resting, and taking non-aspirin pain relievers might help. The best way to prevent chikungunya infection is to avoid mosquito bites: Use insect repellent Wear clothes that cover your arms, legs, and feet Stay in places that have air conditioning or that use window and door screens Centers for Disease Control and Prevention

MalaCards based summary : Chikungunya, also known as chikungunya fever, is related to dengue virus and arthritis, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is OAS3 (2'-5'-Oligoadenylate Synthetase 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs chloroquine and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and heart, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A viral infectious disease that results in infection located in joint, has material basis in Chikungunya virus, which is transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

CDC : 3 Chikungunya virus is spread to people by the bite of an infected mosquito. The most common symptoms of infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with air conditioning or that use window and door screens.

Wikipedia : 77 Chikungunya is an infection caused by the chikungunya virus (CHIKV). Symptoms include fever and joint... more...

Related Diseases for Chikungunya

Diseases related to Chikungunya via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 346)
# Related Disease Score Top Affiliating Genes
1 dengue virus 32.8 DDX58 OAS3 RSAD2
2 arthritis 30.5 CCL2 IL1B IL6 TNF
3 yellow fever 30.1 CCL2 CCL5 IL6 RSAD2
4 japanese encephalitis 29.9 CCL5 DDX58 TNF
5 joint disorders 29.8 IL1B IL6 TNF
6 encephalitis 29.8 CCL2 CCL5 DDX58 IL1B RSAD2
7 kawasaki disease 29.6 CCL2 IL6 TNF
8 crimean-congo hemorrhagic fever 29.6 IL6 TLR8 TNF
9 leptospirosis 29.6 CCL2 IL1B IL6 TNF
10 myocardial infarction 29.6 CCL2 CCL5 IL1B IL6 TNF
11 acute respiratory distress syndrome 29.5 IL1B IL6 TNF
12 toxoplasmosis 29.4 IL1B IL6 TNF
13 synovitis 29.4 IL1B IL6 TNF
14 anterior uveitis 29.4 CCL2 IL6
15 stomatitis 29.3 BST2 DDX58 IL1B RSAD2 TNF
16 malaria 29.3 CCL2 CCL5 IL1B IL6 TNF
17 arteries, anomalies of 29.3 CCL2 IL1B IL6 TNF
18 meningitis 29.3 CCL2 IL1B IL6 TNF
19 rheumatoid arthritis 29.1 CCL2 CCL5 IL1B IL6 TNF
20 neuritis 29.0 CCL2 CCL5 IL1B TNF
21 asthma 28.3 CCL2 CCL5 IL1B IL6 TNF
22 viral infectious disease 28.2 CCL5 DDX58 IL1B IL6 MAVS TLR8
23 systemic lupus erythematosus 28.1 CCL2 CCL5 IL1B IL6 TNF UBE2L3
24 ck syndrome 12.6
25 necrotizing autoimmune myopathy 11.3
26 distal myopathy with vocal cord weakness 11.2
27 isolated hyperckemia 11.1
28 chylomicron retention disease 11.0
29 miyoshi muscular dystrophy 1 11.0
30 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 11.0
31 hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency 11.0
32 myopathy, vacuolar, with casq1 aggregates 11.0
33 dysferlinopathy 11.0
34 phosphoglycerate mutase deficiency 11.0
35 welander distal myopathy, swedish type 11.0
36 acute myocardial infarction 10.4
37 dengue disease 10.4
38 diabetic foot ulcers 10.3 CCL2 IL6
39 noonan syndrome 3 10.3 DDX58 MAVS RSAD2
40 enthesopathy 10.3
41 west nile encephalitis 10.3 BST2 OAS3
42 leukomalacia 10.2 IL6 TNF
43 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
44 keloid formation 10.2 IL6 UBE2L3
45 autoimmune myocarditis 10.2 IL6 TNF
46 critical limb ischemia 10.2 IL6 TNF
47 streptococcal toxic-shock syndrome 10.2 IL6 TNF
48 denture stomatitis 10.2 CCL2 IL6
49 juvenile ankylosing spondylitis 10.2 IL6 TNF
50 cardiogenic shock 10.2 IL6 TNF

Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to Chikungunya

Symptoms & Phenotypes for Chikungunya

Symptoms:

12
  • fever
  • arthralgia
  • maculopapular rash

UMLS symptoms related to Chikungunya:


fever, pruritus

MGI Mouse Phenotypes related to Chikungunya:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CCL5 DDX58 IL1B IL6 MAVS NDST1
2 immune system MP:0005387 9.32 CCL2 CCL5 DDX58 IL1B IL6 MAVS

Drugs & Therapeutics for Chikungunya

Drugs for Chikungunya (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
2 Anti-Inflammatory Agents Phase 3,Not Applicable
3 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Not Applicable
4 Antirheumatic Agents Phase 3,Not Applicable
5 Peripheral Nervous System Agents Phase 3
6 Chloroquine diphosphate Phase 3 50-63-5
7 Anthelmintics Phase 3
8 Anti-Infective Agents Phase 3
9 Antimalarials Phase 3
10 Antiparasitic Agents Phase 3
11 Analgesics Phase 3
12 Antiprotozoal Agents Phase 3
13 Analgesics, Non-Narcotic Phase 3
14
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
15
Aluminum sulfate Approved Phase 2 10043-01-3
16 Antibodies Phase 1, Phase 2,Phase 2
17 Immunologic Factors Phase 1, Phase 2,Phase 2,Not Applicable
18 Immunoglobulins, Intravenous Phase 1, Phase 2
19 gamma-Globulins Phase 1, Phase 2
20 Rho(D) Immune Globulin Phase 1, Phase 2
21 Immunoglobulins Phase 1, Phase 2,Phase 2
22 Vaccines Phase 2,Phase 1
23 Pharmaceutical Solutions Phase 2
24 Antibodies, Monoclonal Phase 1
25
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
26
Pantoprazole Approved Not Applicable 102625-70-7 4679
27
leucovorin Approved Not Applicable 58-05-9 6006 143
28
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
29
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
30
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
31
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
32
Methotrexate Approved Not Applicable 1959-05-2, 59-05-2 126941
33
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
34
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
35
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
36
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
37
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
38 Antimetabolites, Antineoplastic Not Applicable
39 Nucleic Acid Synthesis Inhibitors Not Applicable
40 Methylprednisolone Acetate Not Applicable
41 Vitamin B9 Not Applicable
42 Folate Not Applicable
43 Folic Acid Antagonists Not Applicable
44 Dermatologic Agents Not Applicable
45 Antimetabolites Not Applicable
46 Vitamin B Complex Not Applicable
47 Immunosuppressive Agents Not Applicable
48 Prednisolone acetate Not Applicable

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 CuraChik : A Trial of the Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya Disease Terminated NCT00391313 Phase 3 Chloroquine
3 Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous Immunoglobulins Unknown status NCT02230163 Phase 1, Phase 2
4 Phase II Study to Evaluate Safety and Immunogenicity of a Chikungunya Vaccine Completed NCT02861586 Phase 2
5 Safety, Tolerability and Long-term Immunogenicity of Different Formulations of a Chikungunya Vaccine Recruiting NCT03635086 Phase 2
6 Study of a Live Attenuated Chikungunya Vaccine in a Previously Epidemic Area Active, not recruiting NCT03101111 Phase 2
7 Trial of a Chikungunya Vaccine, PXVX0317 CHIKV-VLP, in Healthy Adults Active, not recruiting NCT03483961 Phase 2
8 Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults Active, not recruiting NCT02562482 Phase 2
9 Chikungunya Vaccine Study in Previously Exposed Adults Not yet recruiting NCT03807843 Phase 2
10 Chikungunya Virus Vaccine Trial in Healthy Adults Completed NCT01489358 Phase 1
11 Phase I Trial of Measles Vectored Chikungungya Vaccine Completed NCT03028441 Phase 1
12 Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of mRNA-1944 in Healthy Adults. Recruiting NCT03829384 Phase 1
13 Safety and Immunogenicity of a Candidate CHIKV Vaccine (CHIK001) Recruiting NCT03590392 Phase 1
14 Study to Assess the Safety and Immunogenicity of a Chikungunya Virus Vaccine Candidate (VLA1553) in Healthy Volunteers Active, not recruiting NCT03382964 Phase 1
15 Safety, Tolerability, and Immunogenicity of VAL-181388 in Healthy Subjects Active, not recruiting NCT03325075 Phase 1
16 Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya Unknown status NCT02281123
17 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Unknown status NCT03078894
18 Chikungunya Arthritis in the Americas Completed NCT02463968
19 The Pilot Study of Chikungunya Virus Infections in Southern Taiwan Completed NCT02174341
20 Impact of the Chikungunya Outbreak in Reunion Island on the Quality of Life After 10 Years Completed NCT02901509
21 Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV Infection Completed NCT02553369
22 Effects of Auriculotherapy on Pain and Functional Capacity of Individuals With Chikungunya Fever Completed NCT03090685 Not Applicable
23 Efficacy of Starting Methotrexate Early in Chikungunya Arthritis Completed NCT03058471 Not Applicable Methotrexate;NSAID;Steroids
24 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico Completed NCT02831699
25 tDCS and Its Therapeutic Effects in CK Fever Completed NCT02993952 Not Applicable
26 A Prospective, Open Label, Treatment Use Study of Patient Safety Following Transfusion of INTERCEPT Platelet Components Completed NCT02305732
27 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Completed NCT02794181
28 Spatial Repellents for Arbovirus Control Completed NCT03553277 Not Applicable
29 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
30 Zika and Microcephaly: Case-control Study Completed NCT02741882
31 Pilot Survey of Dengue Fever in Solomon Islands Completed NCT01868399
32 Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of Congo Completed NCT02656862
33 Effectiveness of and Satisfaction With a Pharmacist-managed Travel Medicine Clinic Completed NCT02625129
34 Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya Recruiting NCT03690648
35 Resistance Exercise Program on the Functionality of Individuals With Chikungunya Fever Recruiting NCT03702348 Not Applicable
36 Impact of Wolbachia Deployment on Arboviral Disease Incidence in Medellin and Bello, Colombia Recruiting NCT03631719
37 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
38 Applying Wolbachia to Eliminate Dengue Recruiting NCT03055585 Not Applicable
39 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
40 World Mosquito Program Noumea - Human Sample Component Recruiting NCT03552094
41 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Recruiting NCT03106714
42 Non Randomized Comparative Study With Control Recruiting NCT03294824
43 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
44 Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children Recruiting NCT03534245
45 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444 Not Applicable
46 ZIKAlliance Pregnant Women Cohort Recruiting NCT03188731
47 Sero-epidemiology of Priority Arboviruses in French Guiana Active, not recruiting NCT03210363 Not Applicable
48 ZIKAlliance Natural History Study Not yet recruiting NCT03204409
49 RT-PCR on Urine Samples: Added Value for the Diagnosis of Chikungunya Virus Infection Suspended NCT02714985

Search NIH Clinical Center for Chikungunya

Genetic Tests for Chikungunya

Anatomical Context for Chikungunya

The Foundational Model of Anatomy Ontology organs/tissues related to Chikungunya:

20
Joint

MalaCards organs/tissues related to Chikungunya:

42
Testes, Heart, T Cells, Brain, Kidney, Skin, Salivary Gland

Publications for Chikungunya

Articles related to Chikungunya:

(show top 50) (show all 2500)
# Title Authors Year
1
Acute Disseminated Encephalomyelitis After Chikungunya Infection. ( 30830174 )
2019
2
The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis. ( 30909365 )
2019
3
Chikungunya in Infants and Children: Is Pathogenesis Increasing? ( 30909568 )
2019
4
Understanding the mechanism of Chikungunya virus vector competence in three species of mosquitoes. ( 30913314 )
2019
5
Novel Mutations in nsP2 Abolish Chikungunya Virus-Induced Transcriptional Shutoff and Make the Virus Less Cytopathic without Affecting Its Replication Rates. ( 30487275 )
2019
6
A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses. ( 30521835 )
2019
7
Clinical and Laboratory Characteristics of an Acute Chikungunya Outbreak in Bangladesh in 2017. ( 30526743 )
2019
8
Molecular Virology of Chikungunya Virus. ( 30599050 )
2019
9
Measles-vectored vaccine approaches against viral infections: a focus on chikungunya. ( 30601074 )
2019
10
Duplex nucleic acid test for the detection of chikungunya and dengue RNA viruses in blood donations. ( 30610766 )
2019
11
Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. ( 30640900 )
2019
12
Emergence of chikungunya and Zika in a municipality endemic to dengue, Santa Luzia, MG, Brazil, 2015-2017. ( 30652797 )
2019
13
Chikungunya as a paradigm for emerging viral diseases: Evaluating disease impact and hurdles to vaccine development. ( 30653504 )
2019
14
Chronic Chikungunya Virus Disease. ( 30656438 )
2019
15
Late Identification of Chikungunya Virus in the Central Nervous System of a 2-Month-Old Infant: Persistence of Maternal-Neonatal Infection? ( 30657982 )
2019
16
Healthcare workers knowledge and diagnostic practices: a need for dengue and chikungunya training in Moshi Municipality, Kilimanjaro Tanzania. ( 30658696 )
2019
17
Viperin controls chikungunya virus-specific pathogenic T cell IFNγ Th1 stimulation in mice. ( 30665948 )
2019
18
Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil. ( 30666934 )
2019
19
East/Central/South African Genotype in a Chikungunya Outbreak, Dhaka, Bangladesh, 2017. ( 30666947 )
2019
20
Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription. ( 30668592 )
2019
21
Infection Pattern of Mayaro Virus in Aedes aegypti (Diptera: Culicidae) and Transmission Potential of the Virus in Mixed Infections With Chikungunya Virus. ( 30668762 )
2019
22
Chikungunya Masquerading as Acute Rheumatism in an Omani Traveler. ( 30671186 )
2019
23
Spectrum of neurological complications in chikungunya fever: experience at a tertiary care centre and review of literature. ( 30678544 )
2019
24
Antiviral activity of ethanolic extract of Nilavembu Kudineer against dengue and chikungunya virus through in vitro evaluation. ( 30685096 )
2019
25
Dengue fever with chikungunya concurrent infection. ( 30692836 )
2019
26
The Italian 2017 Outbreak Chikungunya Virus Belongs to an Emerging Aedes albopictus-Adapted Virus Cluster Introduced From the Indian Subcontinent. ( 30697571 )
2019
27
Correction: The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. ( 30703090 )
2019
28
Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar. ( 30703150 )
2019
29
Chikungunya virus inhibition by synthetic coumarin-guanosine conjugates. ( 30703657 )
2019
30
Virus load and clinical features during the acute phase of Chikungunya infection in children. ( 30707708 )
2019
31
Transcriptional Profile of Aedes aegypti Leucine-Rich Repeat Proteins in Response to Zika and Chikungunya Viruses. ( 30708982 )
2019
32
Excess deaths associated with the 2014 chikungunya epidemic in Jamaica. ( 30714498 )
2019
33
Epidemiology of chikungunya based on laboratory surveillance data-India, 2016-2018. ( 30715511 )
2019
34
Analysis of Salivary Glands and Saliva from Aedes albopictus and Aedes aegypti Infected with Chikungunya Viruses. ( 30717086 )
2019
35
Treatment of Chronic Chikungunya With Methotrexate. ( 30720703 )
2019
36
Comparative study of chikungunya Virus-Like Particles and Pseudotyped-Particles used for serological detection of specific immunoglobulin M. ( 30721816 )
2019
37
Genome sequences of chikungunya virus isolates circulating in midwestern Brazil. ( 30729309 )
2019
38
Phenotypic and genotypic pyrethroid resistance of Aedes albopictus, with focus on the 2017 chikungunya outbreak in Italy. ( 30729706 )
2019
39
Detection of chikungunya virus-specific IgM on laser-cut paper-based device using pseudo-particles as capture antigen. ( 30734316 )
2019
40
51 years in of Chikungunya clinical vaccine development: A historical perspective. ( 30735447 )
2019
41
Tropism of the Chikungunya Virus. ( 30791607 )
2019
42
Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc-FcγR interaction on monocytes. ( 30796092 )
2019
43
Chikungunya and Zika in Huila: Mapping their Incidence in a Neglected Area of Colombia. ( 30799053 )
2019
44
Zika and Chikungunya Virus and Risk for Venous Thromboembolism. ( 30808213 )
2019
45
No chikungunya virus infections among Dutch long-term travellers to (sub)tropical countries: a prospective study 2008-2011. ( 30808283 )
2019
46
Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection. ( 30809003 )
2019
47
A systematic review of individual and community mitigation measures for prevention and control of chikungunya virus. ( 30811438 )
2019
48
Modelling and Analyzing Virus Mutation Dynamics of Chikungunya Outbreaks. ( 30814598 )
2019
49
Undetected Chikungunya virus co-infections in a Brazilian region presenting hyper-endemic circulation of Dengue and Zika. ( 30836281 )
2019
50
Chikungunya Virus: A Back-Breaking Problem. ( 30840767 )
2019

Variations for Chikungunya

Expression for Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for Chikungunya

Pathways related to Chikungunya according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 BST2 CCL2 CCL5 DDX58 IL1B IL6
2
Show member pathways
13.07 BST2 CCL2 CCL5 DDX58 IL1B IL6
3
Show member pathways
13.06 CCL2 CCL5 IL1B IL6 MAVS OAS3
4
Show member pathways
12.87 BST2 CCL2 CCL5 DDX58 IL1B IL6
5
Show member pathways
12.71 CCL5 DDX58 IL1B IL6 MAVS TNF
6
Show member pathways
12.52 CCL2 IL1B IL6 TNF
7
Show member pathways
12.48 BST2 DDX58 OAS3 RSAD2
8
Show member pathways
12.29 CCL2 IL1B IL6 TNF
9
Show member pathways
12.29 CCL2 CCL5 IL1B IL6 TNF
10
Show member pathways
12.21 BST2 IL1B IL6 OAS3 RSAD2 TNF
11
Show member pathways
12.19 IL1B IL6 TLR8 TNF
12
Show member pathways
12.16 IL1B IL6 TLR8 TNF
13 12.07 CCL2 CCL5 DDX58 IL1B MAVS RSAD2
14
Show member pathways
12.03 IL1B IL6 TLR8 TNF
15 12.02 CCL2 IL1B TNF
16
Show member pathways
12 CCL2 CCL5 IL1B IL6
17
Show member pathways
11.97 IL1B IL6 TNF
18 11.97 CCL2 IL1B IL6 TNF
19 11.94 CCL2 IL1B IL6 TNF
20 11.93 CCL2 CCL5 IL1B IL6 TNF
21 11.88 CCL2 IL1B IL6 TNF
22 11.84 IL1B IL6 TNF
23 11.84 IL1B IL6 TNF
24 11.83 DDX58 IL1B TNF
25 11.76 CCL2 CCL5 IL1B IL6 TNF
26
Show member pathways
11.76 CCL2 CCL5 DDX58 IL1B IL6 MAVS
27 11.73 IL1B IL6 TNF
28 11.71 IL1B IL6 TNF
29
Show member pathways
11.64 IL1B IL6 TNF
30 11.62 CCL2 CCL5 IL1B IL6 TNF
31 11.57 IL1B IL6 TNF
32 11.52 CCL2 CCL5 IL1B IL6 TNF
33 11.51 CCL2 IL1B TNF
34 11.5 CCL2 IL1B IL6 TNF
35 11.47 IL1B IL6 TNF
36 11.38 IL1B IL6 TNF
37 11.35 IL1B IL6 TNF
38 11.34 CCL5 IL1B IL6
39 11.3 IL1B IL6 TNF
40 11.27 IL1B IL6 TNF
41 11.24 IL1B IL6 TNF
42 11.24 CCL2 CCL5 IL1B IL6 TNF
43 11.16 CCL2 CCL5 IL1B IL6 TNF
44 10.97 IL6 TNF
45 10.97 CCL2 CCL5 IL1B IL6 TNF
46 10.93 CCL2 IL1B TNF

GO Terms for Chikungunya

Biological processes related to Chikungunya according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.98 CCL2 CCL5 IL1B IL6 TNF
2 MAPK cascade GO:0000165 9.97 CCL2 CCL5 IL1B TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 BST2 IL1B MAVS TNF
4 cellular response to lipopolysaccharide GO:0071222 9.91 CCL2 IL1B IL6 TNF
5 animal organ morphogenesis GO:0009887 9.89 CCL2 NDST1 TNF
6 inflammatory response GO:0006954 9.87 CCL2 CCL5 IL1B IL6 NDST1 TLR8
7 neutrophil chemotaxis GO:0030593 9.86 CCL2 CCL5 IL1B
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 CCL2 CCL5 PHB TNF
9 regulation of insulin secretion GO:0050796 9.85 CCL5 IL1B TNF
10 type I interferon signaling pathway GO:0060337 9.84 BST2 OAS3 RSAD2
11 positive regulation of T cell proliferation GO:0042102 9.84 CCL5 IL1B IL6
12 cellular response to organic cyclic compound GO:0071407 9.84 CCL2 CCL5 IL1B TNF
13 humoral immune response GO:0006959 9.83 BST2 CCL2 IL6 TNF
14 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 DDX58 IL1B IL6 MAVS TNF
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 CCL5 IL6 TNF
16 protein kinase B signaling GO:0043491 9.8 CCL2 CCL5 IL1B TNF
17 monocyte chemotaxis GO:0002548 9.77 CCL2 CCL5 IL6
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 CCL2 CCL5 IL1B TNF
19 negative regulation of neurogenesis GO:0050768 9.75 IL1B IL6 TNF
20 positive regulation of chemokine production GO:0032722 9.72 IL6 TNF
21 microglial cell activation GO:0001774 9.72 TLR8 TNF
22 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
23 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
24 positive regulation of glial cell proliferation GO:0060252 9.72 IL1B IL6 TNF
25 cellular response to exogenous dsRNA GO:0071360 9.71 DDX58 MAVS
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
28 positive regulation of tumor necrosis factor secretion GO:1904469 9.71 DDX58 MAVS
29 positive regulation of interleukin-8 production GO:0032757 9.71 DDX58 IL1B MAVS TNF
30 macrophage chemotaxis GO:0048246 9.7 CCL2 CCL5
31 positive regulation of interferon-alpha production GO:0032727 9.7 DDX58 MAVS
32 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.7 DDX58 IL1B
33 defense response to virus GO:0051607 9.7 BST2 DDX58 IL6 MAVS OAS3 RSAD2
34 positive regulation of interferon-alpha secretion GO:1902741 9.69 DDX58 MAVS
35 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR8 TNF
36 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
37 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
38 response to glucocorticoid GO:0051384 9.68 IL6 TNF
39 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
40 positive regulation of interleukin-6 secretion GO:2000778 9.67 DDX58 IL1B MAVS TLR8
41 positive regulation of myeloid dendritic cell cytokine production GO:0002735 9.66 DDX58 MAVS
42 positive regulation of response to cytokine stimulus GO:0060760 9.65 DDX58 MAVS
43 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.65 IL6 RSAD2
44 positive regulation of neuroinflammatory response GO:0150078 9.65 IL1B IL6 TNF
45 positive regulation of interleukin-6 production GO:0032755 9.65 DDX58 IL1B IL6 TLR8 TNF
46 positive regulation of fever generation GO:0031622 9.64 IL1B TNF
47 positive regulation of interferon-beta secretion GO:0035549 9.63 DDX58 MAVS
48 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.59 IL1B TNF
50 response to virus GO:0009615 9.5 BST2 CCL5 DDX58 OAS3 RSAD2 TLR8

Molecular functions related to Chikungunya according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded RNA binding GO:0003725 9.13 DDX58 OAS3 TLR8
2 cytokine activity GO:0005125 9.02 CCL2 CCL5 IL1B IL6 TNF

Sources for Chikungunya

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