CK
MCID: CHK001
MIFTS: 61

Chikungunya (CK)

Categories: Blood diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Chikungunya

MalaCards integrated aliases for Chikungunya:

Name: Chikungunya 12 76 53 59 43 15
Chikungunya Fever 12 53 3 73
Ck 53 3
Arbovirus a Chikungunya Type 53
Chikungunya Virus Infection 53
Chikv Infection 53
Chik 53

Characteristics:

Orphanet epidemiological data:

59
chikungunya
Prevalence: <1/1000000 (France),<1/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050012
Orphanet 59 ORPHA324625
UMLS via Orphanet 74 C0008055
ICD10 via Orphanet 34 A92.0
ICD10 33 A92.0
UMLS 73 C0008055

Summaries for Chikungunya

MedlinePlus : 43 Chikungunya is a virus that spread by the same kinds of mosquitoes that spread dengue and Zika virus. Rarely, it can spread from mother to newborn around the time of birth. It may also possibly spread through infected blood. There have been outbreaks of chikungunya virus in Africa, Asia, Europe, the Indian and Pacific Oceans, the Caribbean, and Central and South America. Most people who are infected will have symptoms, which can be severe. They usually start 3-7 days after being bitten by an infected mosquito. The most common symptoms are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, and rash. Most people feel better within a week. In some cases, however, the joint pain may last for months. People at risk for more severe disease include newborns, older adults, and people with diseases such as high blood pressure, diabetes, or heart disease. A blood test can show whether you have chikungunya virus. There are no vaccines or medicines to treat it. Drinking lots of fluids, resting, and taking non-aspirin pain relievers might help. The best way to prevent chikungunya infection is to avoid mosquito bites: Use insect repellent Wear clothes that cover your arms, legs, and feet Stay in places that have air conditioning or that use window and door screens Centers for Disease Control and Prevention

MalaCards based summary : Chikungunya, also known as chikungunya fever, is related to dengue virus and arthritis, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is OAS3 (2'-5'-Oligoadenylate Synthetase 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs chloroquine and Anti-Inflammatory Agents, Non-Steroidal have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and heart, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A viral infectious disease that results in infection located in joint, has material basis in Chikungunya virus, which is transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

CDC : 3 Chikungunya (pronunciation: chik-en-gun-ye) virus is transmitted to people by mosquitoes. The most common symptoms of chikungunya virus infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with air conditioning or that use window and door screens.

Wikipedia : 76 Chikungunya is an infection caused by the chikungunya virus (CHIKV). Symptoms include fever and joint... more...

Related Diseases for Chikungunya

Diseases related to Chikungunya via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 334)
# Related Disease Score Top Affiliating Genes
1 dengue virus 32.5 DDX58 OAS3 RSAD2
2 arthritis 30.5 CCL2 IL1B IL6 TNF
3 yellow fever 30.1 CCL2 CCL5 IL6 RSAD2
4 viral infectious disease 30.1 CCL5 DDX58 IL1B IL6 MAVS TLR8
5 ischemic heart disease 30.0 CCL2 IL6 TNF
6 encephalitis 30.0 CCL2 CCL5 DDX58 IL1B RSAD2
7 myocardial infarction 29.9 CCL2 CCL5 IL1B IL6 TNF
8 japanese encephalitis 29.9 CCL5 DDX58 TNF
9 malaria 29.7 CCL2 CCL5 IL1B IL6 TNF
10 leptospirosis 29.7 CCL2 IL1B IL6 TNF
11 anterior uveitis 29.6 IL6 TNF
12 stomatitis 29.6 BST2 DDX58 IL1B RSAD2 TNF
13 crimean-congo hemorrhagic fever 29.5 IL6 TLR8 TNF
14 joint disorders 29.5 IL1B IL6 TNF
15 acute respiratory distress syndrome 29.5 IL1B IL6 TNF
16 toxoplasmosis 29.5 IL1B IL6 TNF
17 arteries, anomalies of 29.4 CCL2 IL1B IL6 TNF
18 synovitis 29.4 IL1B IL6 TNF
19 rheumatoid arthritis 29.4 CCL2 CCL5 IL1B IL6 TNF
20 neuritis 29.3 CCL2 CCL5 IL1B TNF
21 asthma 28.7 CCL2 CCL5 IL1B IL6 TNF
22 psoriasis 28.7 CCL2 CCL5 DDX58 IL1B IL6 TNF
23 ck syndrome 12.6
24 necrotizing autoimmune myopathy 11.2
25 distal myopathy with vocal cord weakness 11.1
26 isolated hyperckemia 11.1
27 chylomicron retention disease 11.0
28 miyoshi muscular dystrophy 1 11.0
29 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 11.0
30 hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency 11.0
31 myopathy, vacuolar, with casq1 aggregates 11.0
32 dysferlinopathy 11.0
33 phosphoglycerate mutase deficiency 11.0
34 welander distal myopathy, swedish type 11.0
35 acute myocardial infarction 10.4
36 dengue disease 10.4
37 enthesopathy 10.2
38 diabetic foot ulcers 10.2 CCL2 IL6
39 west nile encephalitis 10.2 BST2 OAS3
40 noonan syndrome 3 10.2 DDX58 MAVS RSAD2
41 leukomalacia 10.2 IL6 TNF
42 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL6 TNF
43 denture stomatitis 10.1 CCL2 IL6
44 critical limb ischemia 10.1 IL6 TNF
45 streptococcal toxic-shock syndrome 10.1 IL6 TNF
46 juvenile ankylosing spondylitis 10.1 IL6 TNF
47 cardiogenic shock 10.1 IL6 TNF
48 null-cell leukemia 10.1 IL6 TNF
49 scleritis 10.1 CCL2 TNF
50 retinitis pigmentosa 55 10.1 IL6 TNF

Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to Chikungunya

Symptoms & Phenotypes for Chikungunya

Symptoms:

12
  • fever
  • arthralgia
  • maculopapular rash

UMLS symptoms related to Chikungunya:


fever, pruritus

MGI Mouse Phenotypes related to Chikungunya:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CCL5 DDX58 IL1B IL6 MAVS NDST1
2 immune system MP:0005387 9.32 CCL2 CCL5 DDX58 IL1B IL6 MAVS

Drugs & Therapeutics for Chikungunya

Drugs for Chikungunya (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
2 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Not Applicable
3 Anti-Inflammatory Agents Phase 3,Not Applicable
4 Antirheumatic Agents Phase 3,Not Applicable
5 Antiparasitic Agents Phase 3
6 Antiprotozoal Agents Phase 3
7 Chloroquine diphosphate Phase 3 50-63-5
8 Analgesics Phase 3
9 Antimalarials Phase 3
10 Analgesics, Non-Narcotic Phase 3
11 Anti-Infective Agents Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Anthelmintics Phase 3
14
Aluminum sulfate Approved Phase 2 10043-01-3
15
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
16 Antibodies Phase 1, Phase 2,Phase 2
17 Immunoglobulins Phase 1, Phase 2,Phase 2
18 Immunologic Factors Phase 1, Phase 2,Phase 2,Not Applicable
19 Immunoglobulins, Intravenous Phase 1, Phase 2
20 gamma-Globulins Phase 1, Phase 2
21 Rho(D) Immune Globulin Phase 1, Phase 2
22 Pharmaceutical Solutions Phase 2
23 Vaccines Phase 2,Phase 1
24
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
25
Methotrexate Approved Not Applicable 59-05-2, 1959-05-2 126941
26
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
27
leucovorin Approved Not Applicable 58-05-9 6006 143
28
Pantoprazole Approved Not Applicable 102625-70-7 4679
29
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
30
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
31
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
32
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
33
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
34
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
35
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
36
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
37 Methylprednisolone acetate Not Applicable
38 Prednisolone acetate Not Applicable
39 Vitamin B9 Not Applicable
40 Antimetabolites, Antineoplastic Not Applicable
41 Immunosuppressive Agents Not Applicable
42 Antimetabolites Not Applicable
43 Vitamin B Complex Not Applicable
44 Nucleic Acid Synthesis Inhibitors Not Applicable
45 Folic Acid Antagonists Not Applicable
46 Dermatologic Agents Not Applicable
47 Folate Not Applicable

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 CuraChik : A Trial of the Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya Disease Terminated NCT00391313 Phase 3 Chloroquine
3 Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous Immunoglobulins Unknown status NCT02230163 Phase 1, Phase 2
4 Phase II Study to Evaluate Safety and Immunogenicity of a Chikungunya Vaccine Completed NCT02861586 Phase 2
5 Safety, Tolerability and Long-term Immunogenicity of Different Formulations of a Chikungunya Vaccine Recruiting NCT03635086 Phase 2
6 Study of a Live Attenuated Chikungunya Vaccine in a Previously Epidemic Area Active, not recruiting NCT03101111 Phase 2
7 Trial of a Chikungunya Vaccine, PXVX0317 CHIKV-VLP, in Healthy Adults Active, not recruiting NCT03483961 Phase 2
8 Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults Active, not recruiting NCT02562482 Phase 2
9 Chikungunya Vaccine Study in Previously Exposed Adults Not yet recruiting NCT03807843 Phase 2
10 Chikungunya Virus Vaccine Trial in Healthy Adults Completed NCT01489358 Phase 1
11 Safety and Immunogenicity of a Candidate CHIKV Vaccine (CHIK001) Recruiting NCT03590392 Phase 1
12 Study to Assess the Safety and Immunogenicity of a Chikungunya Virus Vaccine Candidate (VLA1553) in Healthy Volunteers Active, not recruiting NCT03382964 Phase 1
13 Safety, Tolerability, and Immunogenicity of VAL-181388 in Healthy Subjects Active, not recruiting NCT03325075 Phase 1
14 Phase I Trial of Measles Vectored Chikungungya Vaccine Active, not recruiting NCT03028441 Phase 1
15 Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya Unknown status NCT02281123
16 Chikungunya Arthritis in the Americas Completed NCT02463968
17 Impact of the Chikungunya Outbreak in Reunion Island on the Quality of Life After 10 Years Completed NCT02901509
18 Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV Infection Completed NCT02553369
19 Effects of Auriculotherapy on Pain and Functional Capacity of Individuals With Chikungunya Fever Completed NCT03090685 Not Applicable
20 Efficacy of Starting Methotrexate Early in Chikungunya Arthritis Completed NCT03058471 Not Applicable Methotrexate;NSAID;Steroids
21 tDCS and Its Therapeutic Effects in CK Fever Completed NCT02993952 Not Applicable
22 A Prospective, Open Label, Treatment Use Study of Patient Safety Following Transfusion of INTERCEPT Platelet Components Completed NCT02305732
23 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
24 Zika and Microcephaly: Case-control Study Completed NCT02741882
25 Pilot Survey of Dengue Fever in Solomon Islands Completed NCT01868399
26 Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of Congo Completed NCT02656862
27 Effectiveness of and Satisfaction With a Pharmacist-managed Travel Medicine Clinic Completed NCT02625129
28 The Pilot Study of Chikungunya Virus Infections in Southern Taiwan Recruiting NCT02174341
29 Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya Recruiting NCT03690648
30 Resistance Exercise Program on the Functionality of Individuals With Chikungunya Fever Recruiting NCT03702348 Not Applicable
31 Sero-epidemiology of Priority Arboviruses in French Guiana Recruiting NCT03210363 Not Applicable
32 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
33 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Recruiting NCT02794181
34 Applying Wolbachia to Eliminate Dengue Recruiting NCT03055585 Not Applicable
35 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
36 Wolbachia Disease Impact in Medellin and Bello Recruiting NCT03631719
37 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Recruiting NCT03106714
38 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Recruiting NCT03078894
39 Non Randomized Comparative Study With Control Recruiting NCT03294824
40 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
41 Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children Recruiting NCT03534245
42 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444 Not Applicable
43 ZIKAlliance Pregnant Women Cohort Recruiting NCT03188731
44 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico Active, not recruiting NCT02831699
45 Spatial Repellents for Arbovirus Control Enrolling by invitation NCT03553277 Not Applicable
46 World Mosquito Program Noumea - Human Sample Component Not yet recruiting NCT03552094
47 ZIKAlliance Natural History Study Not yet recruiting NCT03204409
48 RT-PCR on Urine Samples: Added Value for the Diagnosis of Chikungunya Virus Infection Suspended NCT02714985

Search NIH Clinical Center for Chikungunya

Genetic Tests for Chikungunya

Anatomical Context for Chikungunya

The Foundational Model of Anatomy Ontology organs/tissues related to Chikungunya:

19
Joint

MalaCards organs/tissues related to Chikungunya:

41
Testes, Heart, Skin, T Cells, Kidney, Bone, Brain

Publications for Chikungunya

Articles related to Chikungunya:

(show top 50) (show all 1639)
# Title Authors Year
1
Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin. ( 30388630 )
2019
2
Going Viral 2019: Zika, Chikungunya, and Dengue. ( 30466692 )
2019
3
Temperature dependent transmission potential model for chikungunya in India. ( 30077856 )
2019
4
Limited Evidence for Infection of Urban and Peri-urban Nonhuman Primates with Zika and Chikungunya Viruses in Brazil. ( 29404420 )
2018
5
Encephalitis and transverse myelitis in dengue and chikungunya coinfection. ( 29972580 )
2018
6
Adult-Onset Still Disease and Macrophage Activation Syndrome Following Chikungunya and Hepatitis E Coinfection. ( 29485548 )
2018
7
Complete Genome Sequences of Two Chikungunya Viruses Imported into China. ( 29954886 )
2018
8
Co-circulation and simultaneous co-infection of dengue, chikungunya, and zika viruses in patients with febrile syndrome at the Colombian-Venezuelan border. ( 29382300 )
2018
9
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. ( 29432457 )
2018
10
Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity. ( 29382880 )
2018
11
Emergence and treatment of chikungunya arthritis. ( 29389830 )
2018
12
Patterns of occurrence of Dengue and Chikungunya, and spatial distribution of mosquito vector Aedes albopictus in Swabi district, Pakistan. ( 29956428 )
2018
13
Evaluation of Aedes aegypti (Diptera: Culicidae) Life Table Attributes Upon Chikungunya Virus Replication Reveals Impact on Egg-Laying Pathways. ( 29931258 )
2018
14
Hematologic Parameters and Viral Status for Zika, Chikungunya, Bluetongue, and Epizootic Hemorrhagic Disease in White-tailed Deer ( Odocoileus virginianus) on St John, US Virgin Islands. ( 29792759 )
2018
15
Delayed central nervous system manifestation of Chikungunya virus with magnetic resonance T2 weighted imaging high signal changes-a case report. ( 29942482 )
2018
16
An Assessment of Household and Individual-Level Mosquito Prevention Methods during the Chikungunya Virus Outbreak in the United States Virgin Islands, 2014-2015. ( 29405105 )
2018
17
A summary of the imported cases of Chikungunya fever in Japan from 2006 to June 2016. ( 29394382 )
2018
18
Evidence of previous but not current transmission of chikungunya virus in southern and central Vietnam: Results from a systematic review and a seroprevalence study in four locations. ( 29425199 )
2018
19
Acute inflammatory arthritis: Methotrexate for chronic chikungunya arthritis? ( 29416137 )
2018
20
Chikungunya in U.S. Travelers: A Double Challenge. ( 29978782 )
2018
21
Competitive suppression of dengue virus replication occurs in chikungunya and dengue co-infected Mexican infants. ( 29970133 )
2018
22
Chikungunya virus evolution following a large 3'UTR deletion results in host-specific molecular changes in protein-coding regions. ( 29942653 )
2018
23
Chikungunya Virus Interacts with Heat Shock Cognate 70 Protein to Facilitate Its Entry into Mosquito Cell Line. ( 29953983 )
2018
24
Chikungunya virus infection, immunosuppression and respiratory tract infections: are they associated? ( 29939393 )
2018
25
Comparison of chikungunya viruses generated using infectious clone or the Infectious Subgenomic Amplicons (ISA) method in Aedes mosquitoes. ( 29953474 )
2018
26
Fatal Human Case of Zika and Chikungunya Virus Co-Infection with Prolonged Viremia and Viruria. ( 29933556 )
2018
27
Regulation of the chikungunya-virus-induced innate inflammatory response by protein tyrosine phosphatase non-receptor 6 in muscle cells. ( 29058147 )
2018
28
Effect of Chikungunya Virus Infection on Individuals and the Healthcare System. ( 29437205 )
2018
29
Clinical Profile, Intensive Care Unit Course, and Outcome of Patients Admitted in Intensive Care Unit with Chikungunya. ( 29422725 )
2018
30
Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones. ( 29406692 )
2018
31
Identification of Dengue and Chikungunya Cases Among Suspected Cases of Yellow Fever in the Democratic Republic of the Congo. ( 29768102 )
2018
32
Development of multiplex real time reverse transcriptase PCR assay for simultaneous detection of Zika, Dengue, Yellow Fever and Chikungunya Viruses in a single tube. ( 29979812 )
2018
33
Chikungunya: A rheumatologist's perspective. ( 29431292 )
2018
34
The Burden of Chikungunya Virus Infection: The Need for Systematic and Geriatric-Specific Epidemiological Monitoring. ( 29437206 )
2018
35
Seroprevalence of Dengue Virus, West Nile Virus, Chikungunya Virus, and Zika Virus in International Travelers Attending a Travel and Migration Center in 2015-2017, Southern Italy. ( 29683399 )
2018
36
Susceptibility of Chikungunya Virus to Inactivation by Heat and Commercially and WHO-Recommended Biocides. ( 29917109 )
2018
37
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. ( 29415070 )
2018
38
Ocular manifestations of emerging arboviruses: Dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever. ( 29929827 )
2018
39
Broad and long-lasting immune protection against various Chikungunya genotypes demonstrated by participants in a cross-sectional study in a Cambodian rural community. ( 29410416 )
2018
40
Chikungunya in Children: A Clinical Review. ( 29965820 )
2018
41
Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope. ( 29955082 )
2018
42
Zika, chikungunya and dengue: the causes and threats of new and re-emerging arboviral diseases. ( 29435366 )
2018
43
Chikungunya in Children: A Clinical Review. ( 29965819 )
2018
44
Successful Methotrexate Treatment of Chronic Chikungunya Arthritis. ( 30520824 )
2018
45
The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection. ( 30347791 )
2018
46
Correction of Terminology and Clarification Regarding Chikungunya Antigen Persistence in the Review by Zaid et al (Arthritis Rheumatol, April 2018). ( 30260596 )
2018
47
Vector competence of Aedes bromeliae and Aedes vitattus mosquito populations from Kenya for chikungunya virus. ( 30321181 )
2018
48
Engineering and evaluation of amyloid assemblies as a nanovaccine against the Chikungunya virus. ( 30324958 )
2018
49
Perinatal Outcomes in Vertically Infected Neonates During a Chikungunya Outbreak on the Island of Curaçao. ( 30328407 )
2018
50
Ultrastructural Analysis of Chikungunya Virus Dissemination from the Midgut of the Yellow Fever Mosquito, Aedes aegypti. ( 30340365 )
2018

Variations for Chikungunya

Expression for Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for Chikungunya

Pathways related to Chikungunya according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 BST2 CCL2 CCL5 DDX58 IL1B IL6
2
Show member pathways
13.33 CCL2 CCL5 IL1B IL6 TLR8 TNF
3
Show member pathways
13.07 BST2 CCL2 CCL5 DDX58 IL1B IL6
4
Show member pathways
12.94 BST2 CCL2 CCL5 DDX58 IL1B IL6
5
Show member pathways
12.86 CCL2 CCL5 IL1B IL6 MAVS OAS3
6
Show member pathways
12.72 CCL5 DDX58 IL1B IL6 MAVS TNF
7
Show member pathways
12.63 IL1B IL6 TLR8 TNF
8
Show member pathways
12.53 CCL2 IL1B IL6 TNF
9
Show member pathways
12.48 BST2 DDX58 OAS3 RSAD2
10
Show member pathways
12.3 CCL2 IL1B IL6 TNF
11
Show member pathways
12.29 CCL2 CCL5 IL1B IL6 TNF
12 12.25 DDX58 IL6 MAVS OAS3 TNF
13
Show member pathways
12.21 BST2 IL1B IL6 OAS3 RSAD2 TNF
14
Show member pathways
12.19 IL1B IL6 TLR8 TNF
15
Show member pathways
12.17 IL1B IL6 TLR8 TNF
16 12.07 CCL2 CCL5 DDX58 IL1B MAVS RSAD2
17 12.04 DDX58 MAVS OAS3 TNF
18
Show member pathways
12.03 IL1B IL6 TLR8 TNF
19 12.02 CCL2 IL1B TNF
20
Show member pathways
12.01 CCL2 CCL5 IL1B IL6
21 11.98 CCL2 IL1B IL6 TNF
22
Show member pathways
11.97 IL1B IL6 TNF
23
Show member pathways
11.96 CCL2 CCL5 DDX58 IL1B IL6 MAVS
24 11.95 CCL2 IL1B IL6 TNF
25 11.92 CCL2 CCL5 IL1B IL6 TNF
26 11.88 CCL2 IL1B IL6 TNF
27 11.85 IL1B IL6 TNF
28 11.84 IL1B IL6 TNF
29 11.84 DDX58 IL1B TNF
30 11.79 CCL2 CCL5 IL1B IL6 TNF
31 11.74 IL1B IL6 TNF
32 11.72 IL1B IL6 TNF
33
Show member pathways
11.64 IL1B IL6 TNF
34 11.62 CCL2 CCL5 IL1B IL6 TNF
35 11.58 IL1B IL6 TNF
36 11.52 CCL2 IL1B TNF
37 11.52 CCL2 CCL5 IL1B IL6 TNF
38 11.5 CCL2 IL1B IL6 TNF
39 11.48 IL1B IL6 TNF
40 11.36 IL1B IL6 TNF
41 11.36 IL1B IL6 TNF
42 11.35 CCL5 IL1B IL6
43 11.31 IL1B IL6 TNF
44 11.28 IL1B IL6 TNF
45 11.24 IL1B IL6 TNF
46 11.24 CCL2 CCL5 IL1B IL6 TNF
47 11.16 CCL2 CCL5 IL1B IL6 TNF
48
Show member pathways
11.08 DDX58 MAVS
49 11.05 IL1B TNF
50 11.05 IL6 TNF

GO Terms for Chikungunya

Biological processes related to Chikungunya according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.98 CCL2 CCL5 IL1B IL6 TNF
2 MAPK cascade GO:0000165 9.97 CCL2 CCL5 IL1B TNF
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL2 CCL5 IL1B PHB TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 BST2 IL1B MAVS TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 IL1B IL6 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.9 CCL2 IL1B IL6 TNF
7 animal organ morphogenesis GO:0009887 9.89 CCL2 NDST1 TNF
8 neutrophil chemotaxis GO:0030593 9.87 CCL2 CCL5 IL1B
9 inflammatory response GO:0006954 9.87 CCL2 CCL5 IL1B IL6 NDST1 TLR8
10 regulation of insulin secretion GO:0050796 9.85 CCL5 IL1B TNF
11 response to glucocorticoid GO:0051384 9.85 IL1B IL6 TNF
12 type I interferon signaling pathway GO:0060337 9.85 BST2 OAS3 RSAD2
13 positive regulation of T cell proliferation GO:0042102 9.84 CCL5 IL1B IL6
14 cellular response to organic cyclic compound GO:0071407 9.84 CCL2 CCL5 IL1B TNF
15 humoral immune response GO:0006959 9.83 BST2 CCL2 IL6 TNF
16 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 DDX58 IL1B IL6 MAVS TNF
17 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 CCL5 IL6 TNF
18 protein kinase B signaling GO:0043491 9.81 CCL2 CCL5 IL1B TNF
19 monocyte chemotaxis GO:0002548 9.78 CCL2 CCL5 IL6
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 CCL2 CCL5 IL1B TNF
21 negative regulation of neurogenesis GO:0050768 9.75 IL1B IL6 TNF
22 eosinophil chemotaxis GO:0048245 9.73 CCL2 CCL5
23 positive regulation of chemokine production GO:0032722 9.72 IL6 TNF
24 microglial cell activation GO:0001774 9.72 TLR8 TNF
25 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
26 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
27 positive regulation of glial cell proliferation GO:0060252 9.72 IL1B IL6 TNF
28 cellular response to exogenous dsRNA GO:0071360 9.71 DDX58 MAVS
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
31 positive regulation of tumor necrosis factor secretion GO:1904469 9.71 DDX58 MAVS
32 positive regulation of interleukin-8 production GO:0032757 9.71 DDX58 IL1B MAVS TNF
33 macrophage chemotaxis GO:0048246 9.7 CCL2 CCL5
34 positive regulation of interferon-alpha production GO:0032727 9.7 DDX58 MAVS
35 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.7 DDX58 IL1B
36 positive regulation of interferon-alpha secretion GO:1902741 9.7 DDX58 MAVS
37 defense response to virus GO:0051607 9.7 BST2 DDX58 IL6 MAVS OAS3 RSAD2
38 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR8 TNF
39 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
40 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
41 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
42 positive regulation of neuroinflammatory response GO:0150078 9.67 IL1B IL6 TNF
43 positive regulation of interleukin-6 secretion GO:2000778 9.67 DDX58 IL1B MAVS TLR8
44 positive regulation of myeloid dendritic cell cytokine production GO:0002735 9.66 DDX58 MAVS
45 positive regulation of response to cytokine stimulus GO:0060760 9.65 DDX58 MAVS
46 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.65 IL6 RSAD2
47 positive regulation of interleukin-6 production GO:0032755 9.65 DDX58 IL1B IL6 TLR8 TNF
48 positive regulation of fever generation GO:0031622 9.64 IL1B TNF
49 positive regulation of interferon-beta secretion GO:0035549 9.64 DDX58 MAVS
50 chronic inflammatory response to antigenic stimulus GO:0002439 9.62 IL1B TNF

Molecular functions related to Chikungunya according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded RNA binding GO:0003725 9.13 DDX58 OAS3 TLR8
2 cytokine activity GO:0005125 9.02 CCL2 CCL5 IL1B IL6 TNF

Sources for Chikungunya

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