MCID: CHK001
MIFTS: 61

Chikungunya

Categories: Blood diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Chikungunya

MalaCards integrated aliases for Chikungunya:

Name: Chikungunya 12 77 54 60 44 15
Chikungunya Fever 12 54 3 74
Ck 54 3
Arbovirus a Chikungunya Type 54
Chikungunya Virus Infection 54
Chikv Infection 54
Chik 54

Characteristics:

Orphanet epidemiological data:

60
chikungunya
Prevalence: <1/1000000 (France),<1/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050012
ICD10 34 A92.0
ICD10 via Orphanet 35 A92.0
UMLS via Orphanet 75 C0008055
Orphanet 60 ORPHA324625
UMLS 74 C0008055

Summaries for Chikungunya

MedlinePlus : 44 Chikungunya is a virus that spread by the same kinds of mosquitoes that spread dengue and Zika virus. Rarely, it can spread from mother to newborn around the time of birth. It may also possibly spread through infected blood. There have been outbreaks of chikungunya virus in Africa, Asia, Europe, the Indian and Pacific Oceans, the Caribbean, and Central and South America. Most people who are infected will have symptoms, which can be severe. They usually start 3-7 days after being bitten by an infected mosquito. The most common symptoms are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, and rash. Most people feel better within a week. In some cases, however, the joint pain may last for months. People at risk for more severe disease include newborns, older adults, and people with diseases such as high blood pressure, diabetes, or heart disease. A blood test can show whether you have chikungunya virus. There are no vaccines or medicines to treat it. Drinking lots of fluids, resting, and taking non-aspirin pain relievers might help. The best way to prevent chikungunya infection is to avoid mosquito bites: Use insect repellent Wear clothes that cover your arms, legs, and feet Stay in places that have air conditioning or that use window and door screens Centers for Disease Control and Prevention

MalaCards based summary : Chikungunya, also known as chikungunya fever, is related to arthritis and yellow fever, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is OAS3 (2'-5'-Oligoadenylate Synthetase 3), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs chloroquine and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and t cells, and related phenotypes are cardiovascular system and immune system

Disease Ontology : 12 A viral infectious disease that results in infection located in joint, has material basis in Chikungunya virus, which is transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

CDC : 3 Chikungunya virus is spread to people by the bite of an infected mosquito. The most common symptoms of infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with air conditioning or that use window and door screens.

Wikipedia : 77 Chikungunya is an infection caused by the chikungunya virus (CHIKV). Symptoms include fever and joint... more...

Related Diseases for Chikungunya

Diseases related to Chikungunya via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 359)
# Related Disease Score Top Affiliating Genes
1 arthritis 30.5 CCL2 IL1B IL6 TNF
2 yellow fever 30.3 CCL2 CCL5 IL6
3 measles 30.2 DDX58 IL6 STAT1
4 encephalitis 30.1 CCL2 CCL5 DDX58 IL1B
5 west nile encephalitis 30.0 BST2 OAS3
6 joint disorders 30.0 IL1B IL6 TNF
7 anterior uveitis 29.8 CCL2 IL6
8 kawasaki disease 29.7 CCL2 IL6 TNF
9 leptospirosis 29.6 CCL2 IL1B IL6 TNF
10 myocardial infarction 29.6 CCL2 CCL5 IL1B IL6 TNF
11 stomatitis 29.6 BST2 DDX58 IL1B TNF
12 japanese encephalitis 29.5 CCL5 DDX58 STAT1 TNF
13 adult-onset still's disease 29.5 IL1B IL6 TNF
14 acute respiratory distress syndrome 29.5 IL1B IL6 TNF
15 toxoplasmosis 29.5 IL1B IL6 TNF
16 synovitis 29.4 IL1B IL6 TNF
17 malaria 29.3 CCL2 CCL5 IL1B IL6 TNF
18 arteries, anomalies of 29.3 CCL2 IL1B IL6 TNF
19 meningitis 29.3 CCL2 IL1B IL6 TNF
20 rheumatoid arthritis 29.1 CCL2 CCL5 IL1B IL6 TNF
21 neuritis 29.0 CCL2 CCL5 IL1B TNF
22 asthma 28.4 CCL2 CCL5 IL1B IL6 TNF
23 viral infectious disease 28.3 CCL5 DDX58 IL1B IL6 MAVS STAT1
24 systemic lupus erythematosus 27.7 CCL2 CCL5 IL1B IL6 STAT1 TNF
25 ck syndrome 12.7
26 dengue virus 11.6
27 necrotizing autoimmune myopathy 11.3
28 distal myopathy with vocal cord weakness 11.2
29 isolated hyperckemia 11.1
30 chylomicron retention disease 11.0
31 miyoshi muscular dystrophy 1 11.0
32 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 11.0
33 hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency 11.0
34 myopathy, vacuolar, with casq1 aggregates 11.0
35 dysferlinopathy 11.0
36 phosphoglycerate mutase deficiency 11.0
37 welander distal myopathy, swedish type 11.0
38 acute myocardial infarction 10.5
39 dengue disease 10.4
40 diabetic foot ulcers 10.3 CCL2 IL6
41 enthesopathy 10.3
42 leukomalacia 10.3 IL6 TNF
43 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
44 keloid formation 10.2 IL6 UBE2L3
45 autoimmune myocarditis 10.2 IL6 TNF
46 critical limb ischemia 10.2 IL6 TNF
47 streptococcal toxic-shock syndrome 10.2 IL6 TNF
48 denture stomatitis 10.2 CCL2 IL6
49 juvenile ankylosing spondylitis 10.2 IL6 TNF
50 cardiogenic shock 10.2 IL6 TNF

Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to Chikungunya

Symptoms & Phenotypes for Chikungunya

Symptoms:

12
  • fever
  • arthralgia
  • maculopapular rash

UMLS symptoms related to Chikungunya:


fever, pruritus

MGI Mouse Phenotypes related to Chikungunya:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 G3BP1 IL1B IL6 MAVS NDST1 STAT1
2 immune system MP:0005387 9.28 CCL2 CCL5 DDX58 IL1B IL6 MAVS

Drugs & Therapeutics for Chikungunya

Drugs for Chikungunya (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
2 Antirheumatic Agents Phase 3,Not Applicable
3 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Not Applicable
4 Anti-Inflammatory Agents Phase 3,Not Applicable
5 Antiprotozoal Agents Phase 3
6 Analgesics, Non-Narcotic Phase 3
7 Anti-Infective Agents Phase 3
8 Peripheral Nervous System Agents Phase 3
9 Anthelmintics Phase 3
10 Chloroquine diphosphate Phase 3 50-63-5
11 Antimalarials Phase 3
12 Antiparasitic Agents Phase 3
13 Analgesics Phase 3
14
Aluminum sulfate Approved Phase 2 10043-01-3
15
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
16 Antibodies Phase 1, Phase 2,Phase 2
17 Immunoglobulins, Intravenous Phase 1, Phase 2
18 Immunologic Factors Phase 1, Phase 2,Phase 2,Not Applicable
19 Immunoglobulins Phase 1, Phase 2,Phase 2
20 Rho(D) Immune Globulin Phase 1, Phase 2
21 gamma-Globulins Phase 1, Phase 2
22 Pharmaceutical Solutions Phase 2
23 Vaccines Phase 2,Phase 1
24 Antibodies, Monoclonal Phase 1
25
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
26
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
27
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
28
Methotrexate Approved Not Applicable 1959-05-2, 59-05-2 126941
29
leucovorin Approved Not Applicable 58-05-9 143 6006
30
Pantoprazole Approved Not Applicable 102625-70-7 4679
31
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
32
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
33
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
34
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
35
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
36
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
37
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
38 Nucleic Acid Synthesis Inhibitors Not Applicable
39 Vitamin B9 Not Applicable
40 Methylprednisolone Acetate Not Applicable
41 Immunosuppressive Agents Not Applicable
42 Vitamin B Complex Not Applicable
43 Dermatologic Agents Not Applicable
44 Antimetabolites, Antineoplastic Not Applicable
45 Folic Acid Antagonists Not Applicable
46 Folate Not Applicable
47 Antimetabolites Not Applicable
48 Prednisolone acetate Not Applicable

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) Recruiting NCT03037164 Phase 3
2 CuraChik : A Trial of the Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya Disease Terminated NCT00391313 Phase 3 Chloroquine
3 Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous Immunoglobulins Unknown status NCT02230163 Phase 1, Phase 2
4 Phase II Study to Evaluate Safety and Immunogenicity of a Chikungunya Vaccine Completed NCT02861586 Phase 2
5 Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults Completed NCT02562482 Phase 2
6 Safety, Tolerability and Long-term Immunogenicity of Different Formulations of a Chikungunya Vaccine Recruiting NCT03635086 Phase 2
7 Study of a Live Attenuated Chikungunya Vaccine in a Previously Epidemic Area Active, not recruiting NCT03101111 Phase 2
8 Trial of a Chikungunya Vaccine, PXVX0317 CHIKV-VLP, in Healthy Adults Active, not recruiting NCT03483961 Phase 2
9 Chikungunya Vaccine Study in Previously Exposed Adults Not yet recruiting NCT03807843 Phase 2
10 Chikungunya Virus Vaccine Trial in Healthy Adults Completed NCT01489358 Phase 1
11 Phase I Trial of Measles Vectored Chikungungya Vaccine Completed NCT03028441 Phase 1
12 Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of mRNA-1944 in Healthy Adults. Recruiting NCT03829384 Phase 1
13 Safety and Immunogenicity of a Candidate CHIKV Vaccine (CHIK001) Recruiting NCT03590392 Phase 1
14 Study to Assess the Safety and Immunogenicity of a Chikungunya Virus Vaccine Candidate (VLA1553) in Healthy Volunteers Active, not recruiting NCT03382964 Phase 1
15 Safety, Tolerability, and Immunogenicity of VAL-181388 in Healthy Subjects Active, not recruiting NCT03325075 Phase 1
16 Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya Unknown status NCT02281123
17 A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru Unknown status NCT03078894
18 Chikungunya Arthritis in the Americas Completed NCT02463968
19 The Pilot Study of Chikungunya Virus Infections in Southern Taiwan Completed NCT02174341
20 Impact of the Chikungunya Outbreak in Reunion Island on the Quality of Life After 10 Years Completed NCT02901509
21 Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV Infection Completed NCT02553369
22 Effects of Auriculotherapy on Pain and Functional Capacity of Individuals With Chikungunya Fever Completed NCT03090685 Not Applicable
23 Efficacy of Starting Methotrexate Early in Chikungunya Arthritis Completed NCT03058471 Not Applicable Methotrexate;NSAID;Steroids
24 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico Completed NCT02831699
25 tDCS and Its Therapeutic Effects in CK Fever Completed NCT02993952 Not Applicable
26 A Prospective, Open Label, Treatment Use Study of Patient Safety Following Transfusion of INTERCEPT Platelet Components Completed NCT02305732
27 Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Completed NCT02794181
28 Spatial Repellents for Arbovirus Control Completed NCT03553277 Not Applicable
29 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
30 Zika and Microcephaly: Case-control Study Completed NCT02741882
31 Pilot Survey of Dengue Fever in Solomon Islands Completed NCT01868399
32 Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of Congo Completed NCT02656862
33 Effectiveness of and Satisfaction With a Pharmacist-managed Travel Medicine Clinic Completed NCT02625129
34 Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya Recruiting NCT03690648
35 Resistance Exercise Program on the Functionality of Individuals With Chikungunya Fever Recruiting NCT03702348 Not Applicable
36 Impact of Wolbachia Deployment on Arboviral Disease Incidence in Medellin and Bello, Colombia Recruiting NCT03631719
37 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
38 Applying Wolbachia to Eliminate Dengue Recruiting NCT03055585 Not Applicable
39 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
40 World Mosquito Program Noumea - Human Sample Component Recruiting NCT03552094
41 Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil Recruiting NCT03106714
42 Non Randomized Comparative Study With Control Recruiting NCT03294824
43 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
44 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Recruiting NCT03161444 Not Applicable
45 ZIKAlliance Pregnant Women Cohort Recruiting NCT03188731
46 Sero-epidemiology of Priority Arboviruses in French Guiana Active, not recruiting NCT03210363 Not Applicable
47 Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children Active, not recruiting NCT03534245
48 RT-PCR on Urine Samples: Added Value for the Diagnosis of Chikungunya Virus Infection Suspended NCT02714985
49 ZIKAlliance Natural History Study Suspended NCT03204409

Search NIH Clinical Center for Chikungunya

Genetic Tests for Chikungunya

Anatomical Context for Chikungunya

MalaCards organs/tissues related to Chikungunya:

42
Testes, Heart, T Cells, Kidney, Brain, Prostate, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Chikungunya:

20
Joint

Publications for Chikungunya

Articles related to Chikungunya:

(show top 50) (show all 2549)
# Title Authors Year
1
Acute Disseminated Encephalomyelitis After Chikungunya Infection. ( 30830174 )
2019
2
Brief report: the disability of chronic chikungunya arthritis. ( 30963336 )
2019
3
The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis. ( 30909365 )
2019
4
Emerging trend of dengue and chikungunya fever in Pakistan; Lesson learnt from the past? ( 30980956 )
2019
5
RNA recombination at Chikungunya virus 3'UTR as an evolutionary mechanism that provides adaptability. ( 30986247 )
2019
6
Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus. ( 30987160 )
2019
7
Clinical and laboratory profiles of children with severe chikungunya infection. ( 30994798 )
2019
8
Beyond Fever and Pain: Diagnostic Methods for Chikungunya Virus. ( 30995993 )
2019
9
Epidemiological trend of chikungunya outbreak in Pakistan: 2016-2018. ( 30998759 )
2019
10
Experimental Vertical Transmission of Chikungunya Virus by Brazilian and Florida Aedes Albopictus Populations. ( 30999594 )
2019
11
Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase. ( 31000599 )
2019
12
Intraviral interactome of Chikungunya virus reveals the homo-oligomerization and palmitoylation of structural protein TF. ( 31005258 )
2019
13
Chikungunya Virus Infection-related Rhabdomyolysis: A Case Report. ( 31011498 )
2019
14
Association between air travel and importation of chikungunya into the United States. ( 31011752 )
2019
15
Rare variant of Guillain-Barré syndrome after chikungunya viral fever. ( 31015248 )
2019
16
Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate. ( 31015278 )
2019
17
Frequency, Awareness, and Symptoms of Chikungunya Among Patients in a Tertiary Care Hospital of Karachi: A Cross-Sectional Study. ( 31016081 )
2019
18
Neutralizing Antibodies from Convalescent Chikungunya Virus Patients Can Cross-Neutralize Mayaro and Una Viruses. ( 31017081 )
2019
19
Chikungunya-induced inflammatory myositis: a case report in India. ( 31018774 )
2019
20
Application of a targeted-enrichment methodology for full-genome sequencing of Dengue 1-4, Chikungunya and Zika viruses directly from patient samples. ( 31022183 )
2019
21
Aedes-Chikungunya Virus Interaction: Key Role of Vector Midguts Microbiota and Its Saliva in the Host Infection. ( 31024463 )
2019
22
Vaccination with a chikungunya virus-like particle vaccine exacerbates disease in aged mice. ( 31026260 )
2019
23
P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages. ( 31031770 )
2019
24
Manifestations of Atypical Symptoms of Chikungunya during the Dhaka Outbreak (2017) in Bangladesh. ( 31038100 )
2019
25
Comparative assessment of the replication efficiency of dengue, yellow fever, and chikungunya arboviruses in some insect and mammalian cell lines. ( 31038623 )
2019
26
Short-term pregnancy outcomes in patients chikungunya infection: An observational study. ( 31041238 )
2019
27
An adjuvanted adenovirus 5-based vaccine elicits neutralizing antibodies and protects mice against chikungunya virus-induced footpad swelling. ( 31047675 )
2019
28
Development of an E2 ELISA Methodology to Assess Chikungunya Seroprevalence in Patients from an Endemic Region of Mexico. ( 31052472 )
2019
29
Immunogenicity and Efficacy of a Measles Virus-vectored Chikungunya Vaccine in Nonhuman Primates. ( 31053842 )
2019
30
Severe chikungunya requiring intensive care in two travellers returning to the UK. ( 31066458 )
2019
31
A computational method for the identification of Dengue, Zika and Chikungunya virus species and genotypes. ( 31067235 )
2019
32
IL-27 in patients with Chikungunya Fever: a possible chronicity biomarker? ( 31075222 )
2019
33
Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor. ( 31080061 )
2019
34
Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein. ( 31080063 )
2019
35
Multiplexed kit based on Luminex technology and achievements in synthetic biology discriminates Zika, chikungunya, and dengue viruses in mosquitoes. ( 31088375 )
2019
36
Chikungunya Virus and Zika Virus, Two Different Viruses Examined with a Common Aim: Role of Pattern Recognition Receptors on the Inflammatory Response. ( 31090481 )
2019
37
Infectious Chikungunya Virus with a Complete Capsid Deletion: a New Approach for CHIKV Vaccine. ( 31092567 )
2019
38
Genome sequencing reveals coinfection by multiple chikungunya virus genotypes in a recent outbreak in Brazil. ( 31095561 )
2019
39
Re-emergence of chikungunya in the Republic of the Congo in 2019 associated with a possible vector-host switch. ( 31096054 )
2019
40
A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection. ( 31101672 )
2019
41
Using Big Data to Monitor the Introduction and Spread of Chikungunya, Europe, 2017. ( 31107221 )
2019
42
El Niño southern Oscillation, overseas arrivals and imported chikungunya cases in Australia: A time series analysis. ( 31107863 )
2019
43
Spatiotemporal Heterogeneity in the Distribution of Chikungunya and Zika Virus Case Incidences during their 2014 to 2016 Epidemics in Barranquilla, Colombia. ( 31109024 )
2019
44
In silico T-cell and B-cell Epitope Based Vaccine Design Against Alphavirus Strain of Chikungunya. ( 31109281 )
2019
45
Clinical and Laboratory Characteristics of an Acute Chikungunya Outbreak in Bangladesh in 2017. ( 30526743 )
2019
46
Molecular Virology of Chikungunya Virus. ( 30599050 )
2019
47
Measles-vectored vaccine approaches against viral infections: a focus on chikungunya. ( 30601074 )
2019
48
Duplex nucleic acid test for the detection of chikungunya and dengue RNA viruses in blood donations. ( 30610766 )
2019
49
Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. ( 30640900 )
2019
50
Emergence of chikungunya and Zika in a municipality endemic to dengue, Santa Luzia, MG, Brazil, 2015-2017. ( 30652797 )
2019

Variations for Chikungunya

Expression for Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for Chikungunya

Pathways related to Chikungunya according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 BST2 CCL2 CCL5 DDX58 IL1B IL6
2
Show member pathways
12.97 CCL2 CCL5 IL1B IL6 MAVS OAS3
3
Show member pathways
12.96 BST2 CCL2 CCL5 DDX58 IL1B IL6
4
Show member pathways
12.72 CCL5 DDX58 IL1B IL6 MAVS TNF
5
Show member pathways
12.55 CCL2 IL1B IL6 STAT1 TNF
6
Show member pathways
12.54 IL1B IL6 STAT1 TNF
7
Show member pathways
12.49 BST2 DDX58 OAS3 STAT1
8
Show member pathways
12.4 BST2 CCL2 CCL5 DDX58 IL1B IL6
9 12.38 CCL2 CCL5 DDX58 IL1B MAVS STAT1
10
Show member pathways
12.31 CCL2 IL1B IL6 TNF
11
Show member pathways
12.3 CCL2 CCL5 IL1B IL6 TNF
12
Show member pathways
12.29 IL1B IL6 STAT1 TNF
13 12.22 IL1B IL6 STAT1 TNF
14
Show member pathways
12.21 IL1B IL6 STAT1 TNF
15
Show member pathways
12.21 BST2 IL1B IL6 OAS3 STAT1 TNF
16
Show member pathways
12.19 IL1B IL6 STAT1 TNF
17
Show member pathways
12.17 IL1B IL6 STAT1 TNF
18
Show member pathways
12.05 CCL2 CCL5 IL1B IL6 STAT1
19 12.03 CCL2 IL1B TNF
20
Show member pathways
12.03 IL1B IL6 STAT1 TNF
21 12.01 IL6 STAT1 TNF
22 11.99 IL1B STAT1 TNF
23
Show member pathways
11.98 IL1B IL6 TNF
24 11.97 CCL2 IL1B IL6 TNF
25 11.95 CCL2 IL1B IL6 STAT1 TNF
26 11.92 CCL2 CCL5 IL1B IL6 TNF
27 11.87 DDX58 IL1B TNF
28 11.86 IL1B IL6 TNF
29 11.85 IL1B IL6 TNF
30 11.85 CCL2 IL1B IL6 STAT1 TNF
31 11.76 CCL2 CCL5 IL1B IL6 TNF
32 11.74 IL1B IL6 TNF
33 11.72 IL1B IL6 TNF
34
Show member pathways
11.65 IL1B IL6 TNF
35 11.62 CCL2 CCL5 IL1B IL6 TNF
36 11.59 IL1B IL6 TNF
37 11.52 CCL2 IL1B TNF
38 11.5 CCL2 IL1B IL6 TNF
39 11.48 IL1B IL6 TNF
40 11.45 CCL2 CCL5 IL1B IL6 TNF
41 11.38 IL1B IL6 TNF
42 11.35 IL1B IL6 TNF
43 11.35 CCL5 IL1B IL6
44 11.3 IL1B IL6 TNF
45 11.27 IL1B IL6 TNF
46 11.24 IL1B IL6 TNF
47 11.18 CCL2 CCL5 IL1B IL6 TNF
48
Show member pathways
11.12 DDX58 MAVS STAT1
49 10.99 CCL2 STAT1
50 10.99 IL6 TNF

GO Terms for Chikungunya

Biological processes related to Chikungunya according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.98 CCL2 CCL5 IL1B TNF
2 cytokine-mediated signaling pathway GO:0019221 9.95 CCL2 CCL5 IL1B IL6 STAT1 TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.93 BST2 IL1B MAVS TNF
4 cellular response to lipopolysaccharide GO:0071222 9.92 CCL2 IL1B IL6 TNF
5 cellular response to interferon-gamma GO:0071346 9.88 CCL2 CCL5 STAT1
6 neutrophil chemotaxis GO:0030593 9.87 CCL2 CCL5 IL1B
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 CCL2 CCL5 PHB TNF
8 regulation of insulin secretion GO:0050796 9.86 CCL5 IL1B TNF
9 type I interferon signaling pathway GO:0060337 9.85 BST2 OAS3 STAT1
10 positive regulation of T cell proliferation GO:0042102 9.85 CCL5 IL1B IL6
11 response to cytokine GO:0034097 9.83 CCL5 PHB STAT1
12 positive regulation of interleukin-6 production GO:0032755 9.83 DDX58 IL1B IL6 TNF
13 humoral immune response GO:0006959 9.81 BST2 CCL2 IL6 TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 CCL5 IL6 STAT1 TNF
15 monocyte chemotaxis GO:0002548 9.79 CCL2 CCL5 IL6
16 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
17 positive regulation of defense response to virus by host GO:0002230 9.77 DDX58 MAVS STAT1
18 positive regulation of DNA-binding transcription factor activity GO:0051091 9.77 DDX58 IL1B IL6 MAVS TNF
19 positive regulation of interleukin-6 secretion GO:2000778 9.76 DDX58 IL1B MAVS
20 protein kinase B signaling GO:0043491 9.76 CCL2 CCL5 IL1B TNF
21 positive regulation of chemokine production GO:0032722 9.73 IL6 TNF
22 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
23 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
24 positive regulation of glial cell proliferation GO:0060252 9.73 IL1B IL6 TNF
25 animal organ morphogenesis GO:0009887 9.72 CCL2 TNF
26 cellular response to exogenous dsRNA GO:0071360 9.72 DDX58 MAVS
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
28 interleukin-6-mediated signaling pathway GO:0070102 9.72 IL6 STAT1
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL1B TNF
30 positive regulation of interferon-alpha production GO:0032727 9.72 DDX58 MAVS STAT1
31 response to virus GO:0009615 9.72 BST2 CCL5 DDX58 OAS3 TNF
32 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 CCL2 STAT1
33 positive regulation of tumor necrosis factor secretion GO:1904469 9.71 DDX58 MAVS
34 macrophage chemotaxis GO:0048246 9.71 CCL2 CCL5
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CCL2 CCL5 IL1B TNF
36 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.7 DDX58 IL1B
37 positive regulation of interferon-alpha secretion GO:1902741 9.7 DDX58 MAVS
38 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
39 response to interferon-beta GO:0035456 9.69 BST2 STAT1
40 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
41 response to glucocorticoid GO:0051384 9.68 IL6 TNF
42 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
43 positive regulation of myeloid dendritic cell cytokine production GO:0002735 9.67 DDX58 MAVS
44 positive regulation of response to cytokine stimulus GO:0060760 9.66 DDX58 MAVS
45 response to peptide hormone GO:0043434 9.65 PHB STAT1
46 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
47 positive regulation of interferon-beta secretion GO:0035549 9.64 DDX58 MAVS
48 defense response to virus GO:0051607 9.63 BST2 DDX58 IL6 MAVS OAS3 STAT1
49 sequestering of triglyceride GO:0030730 9.62 IL1B TNF
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF

Molecular functions related to Chikungunya according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL2 CCL5 IL1B IL6 TNF
2 CCR5 chemokine receptor binding GO:0031730 8.96 CCL5 STAT1
3 protein binding GO:0005515 10 BST2 CCL2 CCL5 DDX58 G3BP1 IL1B

Sources for Chikungunya

3 CDC
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17 EFO
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