CK
MCID: CHK001
MIFTS: 57

Chikungunya (CK)

Categories: Blood diseases, Bone diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Chikungunya

MalaCards integrated aliases for Chikungunya:

Name: Chikungunya 12 74 52 58 42 15
Chikungunya Fever 12 52 3 71
Arbovirus a Chikungunya Type 52
Chikungunya Virus Infection 52
Chikv Infection 52
Syndrome, Ck 39
Chik 52
Ck 52

Characteristics:

Orphanet epidemiological data:

58
chikungunya
Prevalence: <1/1000000 (France),<1/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050012
ICD10 32 A92.0
ICD10 via Orphanet 33 A92.0
UMLS via Orphanet 72 C0008055
Orphanet 58 ORPHA324625
UMLS 71 C0008055

Summaries for Chikungunya

MedlinePlus : 42 Chikungunya is a virus that spread by the same kinds of mosquitoes that spread dengue and Zika virus. Rarely, it can spread from mother to newborn around the time of birth. It may also possibly spread through infected blood. There have been outbreaks of chikungunya virus in Africa, Asia, Europe, the Indian and Pacific Oceans, the Caribbean, and Central and South America. Most people who are infected will have symptoms, which can be severe. They usually start 3-7 days after being bitten by an infected mosquito. The most common symptoms are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, and rash. Most people feel better within a week. In some cases, however, the joint pain may last for months. People at risk for more severe disease include newborns, older adults, and people with diseases such as high blood pressure, diabetes, or heart disease. A blood test can show whether you have chikungunya virus. There are no vaccines or medicines to treat it. Drinking lots of fluids, resting, and taking non-aspirin pain relievers might help. The best way to prevent chikungunya infection is to avoid mosquito bites: Use insect repellent Wear clothes that cover your arms, legs, and feet Stay in places that have air conditioning or that use window and door screens Centers for Disease Control and Prevention

MalaCards based summary : Chikungunya, also known as chikungunya fever, is related to dengue virus and exanthem, and has symptoms including fever, arthralgia and maculopapular rash. An important gene associated with Chikungunya is G3BP1 (G3BP Stress Granule Assembly Factor 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs chloroquine and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and skin, and related phenotypes are arthritis and seizures

Disease Ontology : 12 A viral infectious disease that results in infection located in joint, has material basis in Chikungunya virus, which is transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom arthralgia, and has symptom maculopapular rash.

CDC : 3 Chikungunya virus is spread to people by the bite of an infected mosquito. The most common symptoms of infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus, use insect repellent, wear long sleeves and pants, and stay in places with air conditioning or that use window and door screens.

Wikipedia : 74 Chikungunya is an infection caused by the Chikungunya virus (CHIKV). Symptoms include fever and joint... more...

Related Diseases for Chikungunya

Diseases related to Chikungunya via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 726)
# Related Disease Score Top Affiliating Genes
1 dengue virus 33.3 RSAD2 OAS3 DDX58 CD209
2 exanthem 32.0 TNF IL6 IL1B
3 dengue disease 31.5 TNF CD209 CCL5
4 west nile virus 31.4 RSAD2 DDX58 CD209
5 conjunctivitis 31.2 TNF IL6 CCL2
6 yellow fever 31.2 RSAD2 IL6 IL1B CCL5 CCL2
7 meningoencephalitis 31.0 TNF IL6 IL1B CCL5
8 arthritis 30.9 TNF IL6 IL1B CCL5 CCL2
9 myositis 30.9 TNF IL6 IL1B CCL2
10 myocarditis 30.9 TNF IL6 IL1B CCL2
11 optic neuritis 30.9 TNF IL6 IL1B
12 leptospirosis 30.8 TNF IL6 IL1B CCL2
13 toxic shock syndrome 30.8 TNF IL6 IL1B
14 uveitis 30.7 TNF IL6 IL1B CCL2
15 bronchitis 30.7 TNF IL6 IL1B CCL5
16 neuritis 30.6 TNF IL6 IL1B CCL5 CCL2
17 encephalitis 30.6 TNF RSAD2 IL6 IL1B DDX58 CD209
18 japanese encephalitis 30.6 TNF TLR7 RSAD2 CD209 CCL5 CCL2
19 rubella 30.6 TNF IL6 IL1B DDX58
20 aphthous stomatitis 30.5 TNF IL6 IL1B
21 stomatitis 30.5 TNF RSAD2 IL6 IL1B DDX58 BST2
22 pericarditis 30.5 TNF IL6 IL1B
23 carpal tunnel syndrome 30.5 IL6 IL1B CCL2
24 filariasis 30.5 TNF IL6 CCL5
25 allergic encephalomyelitis 30.5 CCL5 CCL2
26 cellulitis 30.5 TNF IL6 IL1B
27 tendinitis 30.5 TNF IL6 IL1B
28 typhoid fever 30.5 TNF IL6 IL1B
29 pharyngitis 30.4 TNF IL6 IL1B
30 septic arthritis 30.4 TNF IL6 IL1B
31 dengue hemorrhagic fever 30.4 TNF TLR8 TLR7 IL6 CD209
32 cryoglobulinemia 30.4 TNF IL6 IL1B
33 autoimmune disease 30.4 TNF IL6 IL1B CCL5 CCL2
34 thrombocytopenia 30.4 TNF TLR7 IL6 IL1B CD209 CCL2
35 lymphocytic choriomeningitis 30.3 MAVS IL6 DDX58
36 plague 30.3 TNF IL6 IL1B DDX58
37 tick-borne encephalitis 30.3 RSAD2 OAS3 DDX58 CD209
38 african tick-bite fever 30.3 TNF IL6 CCL5
39 lichen planus 30.3 TNF IL6 CCL5
40 syphilis 30.2 TNF IL6 CD209
41 graft-versus-host disease 30.2 TNF IL6 IL1B
42 erysipelas 30.2 TNF IL6 IL1B
43 somatoform disorder 30.2 TNF IL6 IL1B
44 measles 30.2 TNF TLR7 IL6 IL1B DDX58 CD209
45 gingivitis 30.1 TNF IL6 IL1B CCL5 CCL2
46 hepatitis a 30.1 TNF MAVS IL1B
47 central nervous system disease 30.1 TNF IL6 IL1B CCL2
48 chorioamnionitis 30.1 TNF IL6 IL1B CCL2
49 mental depression 30.1 TNF IL6 IL1B
50 proteasome-associated autoinflammatory syndrome 1 30.1 TNF IL6 IL1B CCL5 CCL2

Graphical network of the top 20 diseases related to Chikungunya:



Diseases related to Chikungunya

Symptoms & Phenotypes for Chikungunya

Human phenotypes related to Chikungunya:

58 (show top 50) (show all 51)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthritis 58 Frequent (79-30%)
2 seizures 58 Very rare (<4-1%)
3 joint stiffness 58 Frequent (79-30%)
4 photophobia 58 Occasional (29-5%)
5 vomiting 58 Occasional (29-5%)
6 fatigue 58 Very frequent (99-80%)
7 fever 58 Very frequent (99-80%)
8 peripheral neuropathy 58 Occasional (29-5%)
9 skin rash 58 Frequent (79-30%)
10 pruritus 58 Occasional (29-5%)
11 cutaneous photosensitivity 58 Occasional (29-5%)
12 arthralgia 58 Very frequent (99-80%)
13 abnormal blistering of the skin 58 Occasional (29-5%)
14 erythema 58 Frequent (79-30%)
15 macule 58 Frequent (79-30%)
16 skin vesicle 58 Occasional (29-5%)
17 gingival bleeding 58 Occasional (29-5%)
18 osteolysis 58 Very rare (<4-1%)
19 myalgia 58 Frequent (79-30%)
20 depressivity 58 Occasional (29-5%)
21 joint swelling 58 Frequent (79-30%)
22 red eye 58 Occasional (29-5%)
23 paresthesia 58 Very rare (<4-1%)
24 epistaxis 58 Occasional (29-5%)
25 petechiae 58 Occasional (29-5%)
26 headache 58 Frequent (79-30%)
27 abnormal bleeding 58 Occasional (29-5%)
28 encephalitis 58 Very rare (<4-1%)
29 lymphadenopathy 58 Very rare (<4-1%)
30 pedal edema 58 Frequent (79-30%)
31 diarrhea 58 Occasional (29-5%)
32 constrictive median neuropathy 58 Very rare (<4-1%)
33 cervical lymphadenopathy 58 Occasional (29-5%)
34 raynaud phenomenon 58 Very rare (<4-1%)
35 crusting erythematous dermatitis 58 Occasional (29-5%)
36 facial edema 58 Occasional (29-5%)
37 enthesitis 58 Occasional (29-5%)
38 synovitis 58 Occasional (29-5%)
39 erythema nodosum 58 Occasional (29-5%)
40 maculopapular exanthema 58 Frequent (79-30%)
41 depigmentation/hyperpigmentation of skin 58 Frequent (79-30%)
42 chills 58 Occasional (29-5%)
43 shoulder pain 58 Frequent (79-30%)
44 peripheral nerve compression 58 Very rare (<4-1%)
45 periostitis 58 Occasional (29-5%)
46 knee pain 58 Frequent (79-30%)
47 diminished motivation 58 Frequent (79-30%)
48 stiff interphalangeal joints 58 Frequent (79-30%)
49 bursitis 58 Occasional (29-5%)
50 ankle joint effusion 58 Occasional (29-5%)

Symptoms:

12
  • fever
  • arthralgia
  • maculopapular rash

UMLS symptoms related to Chikungunya:


fever, pruritus

MGI Mouse Phenotypes related to Chikungunya:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 CCL2 CCL5 DDX58 FURIN IL1B IL6

Drugs & Therapeutics for Chikungunya

Drugs for Chikungunya (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
2 Antirheumatic Agents Phase 3
3 Anti-Infective Agents Phase 3
4 Antiparasitic Agents Phase 3
5 Amebicides Phase 3
6 Chloroquine diphosphate Phase 3 50-63-5
7 Antiprotozoal Agents Phase 3
8 Antimalarials Phase 3
9
Hydroxychloroquine Approved Phase 2 118-42-3 3652
10
Aluminum sulfate Approved Phase 2 10043-01-3
11
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
12 Rho(D) Immune Globulin Phase 1, Phase 2
13 Immunoglobulins, Intravenous Phase 1, Phase 2
14 gamma-Globulins Phase 1, Phase 2
15
Protoporphyrin IX Experimental Phase 1 553-12-8
16 Vaccines Phase 1
17 Immunoglobulins Phase 1
18 Antibodies Phase 1
19 Antibodies, Monoclonal Phase 1
20 Pharmaceutical Solutions Phase 1
21 Dermatologic Agents Phase 1
22 Photosensitizing Agents Phase 1
23 Tin protoporphyrin IX Phase 1
24
Methylprednisolone Approved, Vet_approved 83-43-2 6741
25
leucovorin Approved 58-05-9 6006 143
26
Methotrexate Approved 59-05-2, 1959-05-2 126941
27
Prednisolone phosphate Approved, Vet_approved 302-25-0
28
Methylprednisolone hemisuccinate Approved 2921-57-5
29
Pantoprazole Approved 102625-70-7 4679
30 Prednisolone acetate Approved, Vet_approved 52-21-1
31
Prednisolone Approved, Vet_approved 50-24-8 5755
32
Mechlorethamine Approved, Investigational 51-75-2 4033
33
Albendazole Approved, Vet_approved 54965-21-8 2082
34
Mebendazole Approved, Vet_approved 31431-39-7 4030
35
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 6474909
36
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
37
Prednisolone hemisuccinate Experimental 2920-86-7
38 Vitamin B Complex
39 Folic Acid Antagonists
40 Methylprednisolone Acetate
41 Anti-Inflammatory Agents
42 Immunosuppressive Agents
43 Folate
44 Antimetabolites
45 Vitamin B9
46 Anti-Inflammatory Agents, Non-Steroidal
47 Sunflower
48 Immunologic Factors

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 Randomized, Double-Blind, Controlled, Parallel Group Study With the INTERCEPT Blood System for RBCs in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections and Treatment Use Open-Label Extension Study Recruiting NCT03037164 Phase 3
2 CuraChik : Double Blind Placebo-controlled Randomized Trial : Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya Disease. Terminated NCT00391313 Phase 3 Chloroquine
3 Prevention of Chikungunya Infection in Neonates: Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous Immunoglobulins Unknown status NCT02230163 Phase 1, Phase 2
4 Phase 2 Randomized, Placebo-Controlled Trial to Evaluate the Safety and Immunogenicity of a Chikungunya Virus-Like Particle Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults Completed NCT02562482 Phase 2
5 Double Blinded, Randomized, Priorix®- and Placebo-controlled, Trial to Evaluate the Optimal Dose of MV-CHIK Vaccine (Against Chikungunya Virus) in Regard to Immunogenicity, Safety and Tolerability in Healthy Volunteers Completed NCT02861586 Phase 2
6 Phase 2 Study of a Live Attenuated Measles Virus-Vectored Chikungunya Vaccine in a Previously Epidemic Area Completed NCT03101111 Phase 2
7 Phase 2 Study of a Live Attenuated Measles Virus-Vectored Chikungunya Vaccine in Previously Exposed Adults Recruiting NCT03807843 Phase 2
8 A Phase 2 Open-label Study to Assess the Safety and Immunogenicity of an Alum-adjuvanted Chikungunya Virus-like Particle Vaccine (PXVX0317) in Prior Recipients of Other Alphavirus Vaccines Versus Alphavirus naïve Controls. Recruiting NCT03992872 Phase 2
9 Hydroxychloroquine for Outpatients With Confirmed COVID-19 Recruiting NCT04342169 Phase 2 Hydroxychloroquine;Placebo oral tablet
10 Observer Blinded, Randomised Study to Investigate Safety, Tolerability and Long-term Immunogenicity of Different Dose Regimens and Formulations of MV-CHIK in Healthy Volunteers Active, not recruiting NCT03635086 Phase 2
11 A Phase 2 Parallel-Group, Randomized, Double-Blind Study to Assess the Safety and Immunogenicity of PXVX0317 (Chikungunya Virus Virus-Like Particle Vaccine [CHIKV-VLP], Unadjuvanted or Alum-adjuvanted) Active, not recruiting NCT03483961 Phase 2
12 A Phase 1, Double Blinded, Placebo Controlled, Dose Comparison Trial to Evaluate the Safety, Immunogenicity and Schedule of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults Completed NCT03028441 Phase 1
13 A Phase I Study to Determine the Safety and Immunogenicity of the Candidate Chikungunya Virus (CHIKV) Vaccine ChAdOx1 Chik in Healthy Adult Volunteers Completed NCT03590392 Phase 1
14 A Phase 1, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety and Immunogenicity of VAL-181388 in Healthy Adults in a Non Endemic Chikungunya Region Completed NCT03325075 Phase 1
15 A Randomized, Observer-Blinded, Dose-Escalation Phase 1 Study to Assess the Safety and Immunogenicity of Three Different Dose Levels of a Live-Attenuated Chikungunya Virus Vaccine Candidate (VLA1553) in Healthy Volunteers Aged 18 To 45 Years Completed NCT03382964 Phase 1
16 VRC 311: A Phase 1 Open Label, Dose-Escalation Clinical Trial to Evaluate the Safety and Immunogenicity of a Virus-Like Particle (VLP) Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults Completed NCT01489358 Phase 1
17 Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine Completed NCT03055000 Phase 1
18 A Phase 1, Randomized, Placebo-Controlled, Dose Ranging Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-1944, Encoding for an Anti-Chikungunya Virus Monoclonal Antibody, in Healthy Adults Recruiting NCT03829384 Phase 1
19 A Phase I Study to Determine the Safety and Immunogenicity of the Candidate Zika Virus (ZIKV) Vaccine ChAdOx1 Zika in Healthy Adult Volunteers Given as a Standalone Vaccine or Co-administered With the Chikungunya Virus (CHIKV) Candidate Vaccine ChAdOx1 Chik Recruiting NCT04015648 Phase 1
20 Characterization of Skin Immunity to Aedes Aegypti Saliva in Dengue-Endemic Participants in Cambodia Recruiting NCT04350905 Phase 1
21 A Single Centre, Double-blind, Double-dummy Placebo-controlled, Randomised Phase Ib Study to Evaluate the Safety & Immunogenicity of the Candidate Chikungunya Vaccine ChAdOx1 Chik & the Zika Vaccine ChAdOx1 Zika in Healthy Adults in Mexico Not yet recruiting NCT04440774 Phase 1
22 A Phase 1, Randomized, Double-Blind, Single Center, Single Dose Escalation Study to Evaluate the Safety, Pharmacokinetics, and Immunogenicity of SAR440894 vs Placebo in Healthy Adults Not yet recruiting NCT04441905 Phase 1
23 Efficacy of Based MRI Contrast Media Against Covid-19 Not yet recruiting NCT04371822 Phase 1 SnPP Protoporphyrin plus Sunlight exposure;SnPP Protoporphyrin plus Sunlight exposure;SnPP Protoporphyrin plus Sunlight exposure;Sulfonatoporphyrin(TPPS) plus Sunlight exposure.
24 Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya Unknown status NCT02281123
25 A Pilot Study Examining for the Presence of Fecal Coliforms in Peruvian Water Sources and the Association of Tropical Diseases Within Peru Unknown status NCT03078894
26 Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. Unknown status NCT03161444
27 Study of Natural Killer Immunity During Infections With CMV or AdV After Allogeneic Hematopoietic Stem Cells Unknown status NCT03294824
28 A Prospective Study to Detect Novel Pathogens and Characterize Emerging Infections Unknown status NCT01979705
29 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment: Cohort Study in Fiocruz/IFF Unknown status NCT03255369
30 Investigate the Prevalence of Serum Chikungunya Virus Infection, and Against Those Suspected Dengue Fever, Chikungunya Disease-related Tests Conducted Completed NCT02174341
31 Study of Zika Virus and Related Arbovirus Infections in Deferred Blood Donors Completed NCT02794181
32 Transcranial Direct Current Stimulation (tDCS) and Its Therapeutic Effects in Chikungunya Fever Completed NCT02993952
33 Efficacy of Starting Methotrexate Early in Chikungunya Arthritis:A 24 Week Randomized Controlled Open Label Crossover Trial Completed NCT03058471 Methotrexate;NSAID;Steroids
34 Effects of Auriculotherapy on Pain and Functional Capacity of Individuals With Chikungunya Fever Completed NCT03090685
35 Epidémie de Chikungunya à l'île de La Réunion : Effet à Dix Ans de l'Infection Sur la qualité de Vie Dans la Cohorte TELECHIK Completed NCT02901509
36 Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV Infection Completed NCT02553369
37 A Pilot Study of the Pathogenesis of Chikungunya Arthritis in the Americas Completed NCT02463968
38 A Prospective, Open Label, Treatment Use Study of Patient Safety Following Transfusion of INTERCEPT Platelet Components Completed NCT02305732
39 The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico (Zik01) Completed NCT02831699
40 Quantification of GADD34 Expression in Rheumatoid Arthritis Completed NCT02401165
41 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Completed NCT03206541
42 Pilot Survey of Dengue Fever in Solomon Islands Completed NCT01868399
43 Prospective Surveillance and Case Definition Study of Zika Virus Disease and Infection in Adolescents and Adults in Latin America in Preparation for an Efficacy Trial of a Zika Virus Whole Virion, Purified Inactivated Vaccine Completed NCT03158233
44 Spatial Repellent Products for Control of Vector-borne Diseases - Dengue Completed NCT03553277
45 Rash Accompanied by Three or More Dengue-like Symptoms During Pregnancy and Microcephaly: Case-control Study Completed NCT02741882
46 Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of Congo Completed NCT02656862
47 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
48 Clinical Effectiveness of Standard Versus Pathogen-reduced Buffy Coat-derived Platelet Concentrates in Plasma in Hemato-oncological Patients. Completed NCT02783313
49 Defining Skin Immunity of a Bite of Key Insect Vectors in Humans Completed NCT03641339
50 Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya Fever: Genome-wide Association Study Recruiting NCT03690648

Search NIH Clinical Center for Chikungunya

Genetic Tests for Chikungunya

Anatomical Context for Chikungunya

The Foundational Model of Anatomy Ontology organs/tissues related to Chikungunya:

19
Joint

MalaCards organs/tissues related to Chikungunya:

40
Testes, Skin, Heart, T Cells, Brain, Monocytes, Eye

Publications for Chikungunya

Articles related to Chikungunya:

(show top 50) (show all 5148)
# Title Authors PMID Year
1
Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. 61 42
32559197 2020
2
Development of a portable reverse transcription loop-mediated isothermal amplification system to detect the E1 region of Chikungunya virus in a cost-effective manner. 61 42
32562326 2020
3
Inverse association between dengue, chikungunya, and Zika virus infection and indicators of household air pollution in Santa Rosa, Guatemala: A case-control study, 2011-2018. 61 42
32559225 2020
4
A review on Zika virus outbreak, epidemiology, transmission and infection dynamics. 61
32158705 2020
5
Ontology-driven aspect-based sentiment analysis classification: An infodemiological case study regarding infectious diseases in Latin America. 61
32572291 2020
6
Emerging vaccine manufacturers are innovating for the next decade. 61
32462140 2020
7
Chikungunya phylogeography reveals persistent global transmissions of the Indian Ocean Lineage from India in association with mutational fitness. 61
32198074 2020
8
[Indoor thermal fogging of the mixture of flupyradifurone and transflutrin on Aedes aegypti mosquitoes susceptible and resistant to pyrethroids in southern Mexico]. 61
32250091 2020
9
Green synthesis of nanometal impregnated biomass - antiviral potential. 61
32409081 2020
10
Microsatellite typing of Aedes albopictus (Diptera: Culicidae) populations from Germany suggests regular introductions. 61
32045712 2020
11
The V1016G mutation of the voltage-gated sodium channel (VGSC) gene contributes to the insecticide resistance of Aedes aegypti from Makassar, Indonesia. 61
32458116 2020
12
Impact of venereal transmission on the dynamics of vertically transmitted viral diseases among mosquitoes. 61
32387647 2020
13
Transmission of Chikungunya Virus in an Urban Slum, Brazil. 61
32568045 2020
14
Alphavirus capsid protease inhibitors as potential antiviral agents for Chikungunya infection. 61
32380148 2020
15
Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches? 61
32333884 2020
16
Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti. 61
32378259 2020
17
Proteomic analysis of CHIKV-infected human fibroblast-like synoviocytes: Identification of host factors potentially associated with CHIKV replication and cellular pathogenesis. 61
32246487 2020
18
Assessment of Resistance to Organophosphates and Pyrethroids in Aedes aegypti (Diptera: Culicidae): Do Synergists Affect Mortality? 61
32484559 2020
19
Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells. 61
32374474 2020
20
Antiviral Natural Products for Arbovirus Infections. 61
32560438 2020
21
AYUSH for COVID-19: Science or Superstition? 61
32496237 2020
22
Reconstructing Mayaro virus circulation in French Guiana shows frequent spillovers. 61
32503971 2020
23
Understanding risk perception from traditional knowledge of Mayan farmers on Rickettsioses. 61
32552437 2020
24
Implementation of geographical information systems for the study of diseases caused by vector-borne arboviruses in Southeast Asia: A review based on the publication record. 61
32575973 2020
25
Evaluation of the public health risk for autochthonous transmission of mosquito-borne viruses in southern Switzerland. 61
31802522 2020
26
The limited knowledge of placental damage due to neglected infections: ongoing problems in Latin America. 61
32482148 2020
27
Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen. 61
32533071 2020
28
Characteristics of Chikungunya virus infection in patients with established rheumatoid arthritis. 61
32514679 2020
29
Environmental influences on Aedes aegypti catches in Biogents Sentinel traps during a Californian "rear and release" program: Implications for designing surveillance programs. 61
32530921 2020
30
Mobile Laboratory Reveals the Circulation of Dengue Virus Serotype I of Asian Origin in Medina Gounass (Guediawaye), Senegal. 61
32560073 2020
31
Hydroxychloroquine use in the COVID-19 patient. 61
32371558 2020
32
Chikungunya in Indonesia: Epidemiology and diagnostic challenges. 61
32479497 2020
33
Harnessing Dengue Rapid Diagnostic Tests for the Combined Surveillance of Dengue, Zika, and Chikungunya Viruses in Laos. 61
32157991 2020
34
Coordination among neighbors improves the efficacy of Zika control despite economic costs. 61
32569323 2020
35
Dynamic proteomic analysis of Aedes aegypti Aag-2 cells infected with Mayaro virus. 61
32522239 2020
36
Experience in diagnosing congenital Zika syndrome in Brazilian children born to asymptomatic mothers. 61
32165128 2020
37
Tracing temporal and geographic distribution of resistance to pyrethroids in the arboviral vector Aedes albopictus. 61
32569337 2020
38
Insecticide resistance, fitness and susceptibility to Zika infection of an interbred Aedes aegypti population from Rio de Janeiro, Brazil. 61
32513248 2020
39
INCREASED SERUM LEVELS OF GALECTIN-9 IN PATIENTS WITH CHIKUNGUNYA FEVER. 61
32565125 2020
40
Chikungunya outbreak (2015) in the Colombian Caribbean: Latent classes and gender differences in virus infection. 61
32492017 2020
41
Musculoskeletal Disorders due to Chikungunya Virus: A Real Experience in a Rheumatology Department in Neiva, Huila. 61
32576537 2020
42
Serotonergic Drugs Inhibit Chikungunya Virus Infection at Different Stages of the Cell Entry Pathway. 61
32321803 2020
43
Factors Associated with Chikungunya Relapse in Acapulco, Mexico: A Cross-Sectional Study. 61
32552425 2020
44
Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery. 61
32340991 2020
45
Investigating the utility of Google trends for Zika and Chikungunya surveillance in Venezuela. 61
32546159 2020
46
Standardization of ELISA for anti-chikungunya-IgG antibodies and age-stratified prevalence of anti-chikungunya-IgG antibodies in Pune, India. 61
32504313 2020
47
Chikungunya Virus Infection Impairs the Function of Osteogenic Cells. 61
32493723 2020
48
Chikungunya vaccine: a single shot for a long protection? 61
32497525 2020
49
About 3 cases of post-acute retinopathy of chikungunya fever. 61
32505386 2020
50
[Chronic chikungunya arthritis]. 61
32333101 2020

Variations for Chikungunya

Expression for Chikungunya

Search GEO for disease gene expression data for Chikungunya.

Pathways for Chikungunya

Pathways related to Chikungunya according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNF TLR8 TLR7 RSAD2 OAS3 MAVS
2
Show member pathways
13.29 TNF RSAD2 OAS3 KPNA4 IL6 IL1B
3
Show member pathways
12.93 TNF IL6 IL1B CCL5 CCL2 BST2
4
Show member pathways
12.78 TNF TLR8 TLR7 RSAD2 OAS3 MAVS
5
Show member pathways
12.72 TNF TLR8 TLR7 IL6 IL1B
6
Show member pathways
12.7 TNF TLR8 TLR7 IL6 IL1B
7 12.6 TNF OAS3 MAVS IL6 IL1B DDX58
8
Show member pathways
12.56 MAVS IL6 IL1B DDX58 CCL5
9
Show member pathways
12.54 RSAD2 OAS3 KPNA4 DDX58 BST2
10
Show member pathways
12.33 TNF IL6 IL1B CCL2
11
Show member pathways
12.33 TNF IL6 CCL5 CCL2
12 12.31 TNF KPNA4 IL6 IL1B
13
Show member pathways
12.31 TNF IL6 IL1B CCL5 CCL2
14
Show member pathways
12.26 TNF TLR8 TLR7 IL6
15
Show member pathways
12.24 TNF RSAD2 OAS3 IL6 IL1B BST2
16 12.23 TNF IL6 IL1B CD209
17
Show member pathways
12.2 TNF TLR8 IL6 IL1B CD209
18 12.19 TNF TLR8 TLR7 IL6
19
Show member pathways
12.16 TNF TLR8 TLR7 IL6 IL1B
20 12.12 TNF OAS3 MAVS IL6 IL1B CCL5
21 12.12 TNF TLR8 TLR7 RSAD2 MAVS IL1B
22
Show member pathways
12.07 TNF TLR7 RSAD2 OAS3 MAVS IL6
23 12.01 TNF IL6 IL1B CCL2
24 12 TNF IL6 IL1B CCL2
25 11.97 TNF IL6 IL1B CCL2
26 11.96 TNF IL6 IL1B CCL5 CCL2
27
Show member pathways
11.92 TNF TLR8 TLR7 IL6 IL1B
28 11.9 TNF IL6 IL1B CCL2
29
Show member pathways
11.85 TLR8 TLR7 IL6 IL1B
30 11.82 TNF IL6 IL1B CCL5 CCL2
31 11.75 TNF IL6 IL1B
32 11.7 TNF TLR7 IL6 IL1B CD209
33
Show member pathways
11.66 TNF IL6 IL1B
34 11.61 TNF IL6 IL1B
35 11.6 TNF IL6 IL1B CCL5 CCL2
36 11.54 TNF IL6 IL1B CCL2
37 11.52 TNF IL1B CCL2
38 11.49 TNF IL6 IL1B
39 11.46 TNF IL6 IL1B CCL5 CCL2
40 11.39 TNF IL6 IL1B
41 11.36 IL6 IL1B CCL5
42 11.36 TNF IL6 IL1B
43 11.31 TNF IL6 IL1B
44 11.28 TNF IL6 IL1B
45 11.24 TNF IL6 IL1B
46 10.96 TNF IL1B CCL2
47 10.78 IL6 IL1B

GO Terms for Chikungunya

Biological processes related to Chikungunya according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.1 TLR8 TLR7 RSAD2 OAS3 MAVS G3BP2
2 viral process GO:0016032 10.09 RSAD2 MXRA8 MAVS KPNA4 G3BP2 G3BP1
3 immune response GO:0006955 10.08 TNF TLR8 TLR7 OAS3 IL6 IL1B
4 inflammatory response GO:0006954 10.04 TNF TLR8 TLR7 IL6 IL1B CCL5
5 cytokine-mediated signaling pathway GO:0019221 10.03 TNF IL6 IL1B CCL5 CCL2
6 innate immune response GO:0045087 10.02 TLR8 TLR7 RSAD2 OAS3 MAVS G3BP2
7 cellular protein metabolic process GO:0044267 10 ZDHHC2 MXRA8 IL6 FURIN
8 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 TNF MAVS IL1B BST2
9 cellular response to lipopolysaccharide GO:0071222 9.96 TNF IL6 IL1B CCL2
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 TNF MAVS IL6 IL1B DDX58
11 cellular response to mechanical stimulus GO:0071260 9.89 TLR8 TLR7 IL1B
12 neutrophil chemotaxis GO:0030593 9.89 IL1B CCL5 CCL2
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 TNF IL6 CCL5
14 cellular response to organic cyclic compound GO:0071407 9.88 TNF IL1B CCL5 CCL2
15 regulation of insulin secretion GO:0050796 9.87 TNF IL1B CCL5
16 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.87 TNF TLR8 TLR7
17 type I interferon signaling pathway GO:0060337 9.87 RSAD2 OAS3 BST2
18 regulation of protein phosphorylation GO:0001932 9.87 TNF TLR8 TLR7
19 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.86 TNF TLR7 IL1B
20 positive regulation of T cell proliferation GO:0042102 9.86 IL6 IL1B CD209 CCL5
21 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 TNF IL6 CCL5
22 humoral immune response GO:0006959 9.85 TNF IL6 CCL2
23 positive regulation of interleukin-6 secretion GO:2000778 9.85 TNF TLR8 MAVS IL1B DDX58
24 protein kinase B signaling GO:0043491 9.83 TNF IL1B CCL5 CCL2
25 monocyte chemotaxis GO:0002548 9.82 IL6 CCL5 CCL2
26 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF IL1B CCL5 CCL2
27 positive regulation of JAK-STAT cascade GO:0046427 9.8 TNF IL6 CCL5
28 microglial cell activation GO:0001774 9.79 TNF TLR8 TLR7
29 negative regulation of neurogenesis GO:0050768 9.79 TNF IL6 IL1B
30 positive regulation of chemokine production GO:0032722 9.77 TNF TLR7 IL6
31 positive regulation of glial cell proliferation GO:0060252 9.77 TNF IL6 IL1B
32 positive regulation of interleukin-8 production GO:0032757 9.77 TNF TLR7 MAVS IL1B DDX58
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.76 TNF IL1B FURIN
34 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TNF TLR8 TLR7
35 positive regulation of interleukin-6 production GO:0032755 9.73 TNF TLR8 TLR7 IL6 IL1B DDX58
36 positive regulation of chemokine biosynthetic process GO:0045080 9.72 TNF IL1B
37 positive regulation of interferon-alpha production GO:0032727 9.72 MAVS DDX58
38 positive regulation of neuroinflammatory response GO:0150078 9.72 TNF IL6 IL1B
39 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.71 IL1B DDX58
40 positive regulation of interferon-alpha secretion GO:1902741 9.71 MAVS DDX58
41 negative regulation of lipid storage GO:0010888 9.71 TNF IL6
42 response to virus GO:0009615 9.7 TNF TLR8 RSAD2 OAS3 DDX58 CCL5
43 regulation of establishment of endothelial barrier GO:1903140 9.69 TNF IL1B
44 positive regulation of interferon-beta biosynthetic process GO:0045359 9.68 TLR8 TLR7
45 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.68 RSAD2 IL6
46 positive regulation of response to cytokine stimulus GO:0060760 9.67 MAVS DDX58
47 positive regulation of myeloid dendritic cell cytokine production GO:0002735 9.66 MAVS DDX58
48 positive regulation of interferon-beta secretion GO:0035549 9.65 MAVS DDX58
49 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
50 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.64 TLR8 TLR7

Molecular functions related to Chikungunya according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 TNF IL6 IL1B CCL5 CCL2
2 single-stranded RNA binding GO:0003727 9.33 TLR8 TLR7 DDX58
3 double-stranded RNA binding GO:0003725 8.92 TLR8 TLR7 OAS3 DDX58

Sources for Chikungunya

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
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36 KEGG
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61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
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70 Tocris
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72 UMLS via Orphanet
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