MCID: CHL158
MIFTS: 20

Childhood Acute Megakaryoblastic Leukemia

Categories: Blood diseases, Cancer diseases
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Aliases & Classifications for Childhood Acute Megakaryoblastic Leukemia

MalaCards integrated aliases for Childhood Acute Megakaryoblastic Leukemia:

Name: Childhood Acute Megakaryoblastic Leukemia 11 14 16
Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia 11

Classifications:



External Ids:

Disease Ontology 11 DOID:0080794
NCIt 49 C7972

Summaries for Childhood Acute Megakaryoblastic Leukemia

Disease Ontology: 11 An acute megakaryocytic leukemia that is characterized by fusion oncogenes involving transcriptional regulators in childhood.

MalaCards based summary: Childhood Acute Megakaryoblastic Leukemia, also known as pediatric non-down syndrome acute megakaryoblastic leukemia, is related to leukemia, acute monocytic and acute megakaryoblastic leukemia without down syndrome. An important gene associated with Childhood Acute Megakaryoblastic Leukemia is CBFA2T3 (CBFA2/RUNX1 Partner Transcriptional Co-Repressor 3), and among its related pathways/superpathways is Assembly of the pre-replicative complex.

Related Diseases for Childhood Acute Megakaryoblastic Leukemia

Diseases related to Childhood Acute Megakaryoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute monocytic 29.8 NUP98 KMT2A
2 acute megakaryoblastic leukemia without down syndrome 29.6 NUP98 KMT2A KDM5A GLIS2 CBFA2T3
3 myelodysplastic syndrome 29.5 NUP98 KMT2A GP1BA GATA1
4 childhood leukemia 29.5 NUP98 KMT2A GATA1 CBFA2T3
5 childhood acute myeloid leukemia 29.3 NUP98 KMT2A KDM5A GLIS2 CBFA2T3
6 acute megakaryocytic leukemia 29.1 NUP98 KMT2A KDM5A ITGA2B GP1BA GLIS2
7 leukemia, acute myeloid 29.0 NUP98 KMT2A KDM5A ITGA2B GLIS2 GATA1
8 down syndrome 10.5
9 leukemia 10.3
10 acute myeloid leukemia with recurrent genetic anomaly 10.3
11 acute megakaryoblastic leukemia in down syndrome 10.2
12 myelofibrosis 10.1
13 histiocytic sarcoma 10.1
14 hematologic cancer 10.1
15 fibrosarcoma of bone 10.1
16 histiocytosis 10.1
17 monocytic leukemia 10.1
18 acute monoblastic leukemia 10.1
19 ring chromosome 10.1
20 myeloid leukemia associated with down syndrome 10.0 GLIS2 GATA1 CBFA2T3
21 pseudo-von willebrand disease 10.0 GP1BA GATA1
22 fetal and neonatal alloimmune thrombocytopenia 10.0 ITGA2B GP1BA
23 autosomal dominant macrothrombocytopenia 10.0 ITGA2B GP1BA
24 gray platelet syndrome 10.0 ITGA2B GATA1
25 qualitative platelet defect 10.0 ITGA2B GP1BA
26 acquired thrombocytopenia 10.0 ITGA2B GP1BA
27 bleeding disorder, platelet-type, 11 10.0 ITGA2B GP1BA
28 carotid artery thrombosis 10.0 ITGA2B GP1BA
29 thrombasthenia 9.9 ITGA2B GP1BA
30 infective endocarditis 9.9 ITGA2B GP1BA
31 fetal hemoglobin quantitative trait locus 1 9.9 ITGA2B GATA1
32 primary thrombocytopenia 9.9 ITGA2B GP1BA
33 coronary thrombosis 9.9 ITGA2B GP1BA
34 thrombocytopenia due to platelet alloimmunization 9.9 ITGA2B GP1BA
35 acute erythroid leukemia 9.9 ITGA2B GATA1 CBFA2T3
36 von willebrand's disease 9.9 ITGA2B GP1BA
37 neonatal leukemia 9.9 KMT2A GATA1
38 beta-thalassemia major 9.9 ITGA2B GATA1
39 thrombocytopenic purpura, autoimmune 9.9 ITGA2B GP1BA
40 purpura 9.9 ITGA2B GP1BA
41 amegakaryocytic thrombocytopenia, congenital 9.8 ITGA2B GP1BA GATA1
42 bernard-soulier syndrome 9.8 ITGA2B GP1BA GATA1
43 glanzmann thrombasthenia 1 9.8 ITGA2B GP1BA
44 blood platelet disease 9.8 ITGA2B GP1BA GATA1
45 essential thrombocythemia 9.8 ITGA2B GP1BA GATA1
46 precursor t-cell acute lymphoblastic leukemia 9.7 NUP98 KMT2A
47 acute leukemia 9.7 NUP98 KMT2A GATA1
48 hemorrhagic disease 9.6 ITGA2B GP1BA
49 myeloid leukemia 9.6 NUP98 KMT2A KDM5A CBFA2T3
50 myeloproliferative syndrome, transient 9.1 KMT2A ITGA2B GP1BA GLIS2 GATA1 CBFA2T3

Graphical network of the top 20 diseases related to Childhood Acute Megakaryoblastic Leukemia:



Diseases related to Childhood Acute Megakaryoblastic Leukemia

Symptoms & Phenotypes for Childhood Acute Megakaryoblastic Leukemia

Drugs & Therapeutics for Childhood Acute Megakaryoblastic Leukemia

Search Clinical Trials, NIH Clinical Center for Childhood Acute Megakaryoblastic Leukemia

Genetic Tests for Childhood Acute Megakaryoblastic Leukemia

Anatomical Context for Childhood Acute Megakaryoblastic Leukemia

Publications for Childhood Acute Megakaryoblastic Leukemia

Articles related to Childhood Acute Megakaryoblastic Leukemia:

(show all 19)
# Title Authors PMID Year
1
Frequent detection of CBFA2T3::GLIS2 fusion and RAM-phenotype in pediatric non-Down syndrome acute megakaryoblastic leukemia: a possible novel relationship with aberrant cytoplasmic CD3 expression. 62
36346368 2022
2
Clinical Characteristics and Prognosis of 27 Patients with Childhood Acute Megakaryoblastic Leukemia. 62
32532951 2020
3
The changing scenario of non-Down syndrome acute megakaryoblastic leukemia in children. 62
31092368 2019
4
Outcome of Childhood Acute Megakaryoblastic Leukemia: Children's Cancer Hospital Egypt 57357 Experience. 62
30686774 2019
5
Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. 62
28112737 2017
6
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study. 62
26215111 2015
7
MiR-125b and miR-99a encoded on chromosome 21 co-regulate vincristine resistance in childhood acute megakaryoblastic leukemia. 62
25571789 2015
8
Mosaic Trisomy 21 and Trisomy 14 as Acquired Cytogenetic Abnormalities without GATA1 Mutation in A Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia. 62
23467713 2011
9
Ring/marker chromosome derived from chromosome 7 in childhood acute megakaryoblastic leukemia with monosomy 7. 62
20809201 2010
10
[Childhood acute megakaryoblastic leukemia]. 62
17605859 2007
11
CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. 62
17071479 2006
12
Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. 62
12649131 2003
13
Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience. 62
11389009 2001
14
Induction of the erythropoietin receptor gene and acquisition of responsiveness to erythropoietin by stem cell factor in HML/SE, a human leukemic cell line. 62
9642254 1998
15
Expression of MDR-1/P-glycoprotein in childhood acute megakaryoblastic leukemia cells. 62
8590843 1995
16
Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases. 62
8220128 1993
17
[Induction of complete remission in a case of drug-resistant childhood acute megakaryoblastic leukemia by combination of G-CSF and chemotherapy]. 62
1374487 1992
18
Differentiation induction of blast cells in two cases of childhood acute megakaryoblastic leukemia in vitro by interleukin-3 and interleukin-6: an ultrastructural cytochemical study. 62
1655816 1991
19
Childhood acute megakaryoblastic leukemia with internalization of hemic cells. 62
2285130 1990

Variations for Childhood Acute Megakaryoblastic Leukemia

Expression for Childhood Acute Megakaryoblastic Leukemia

Search GEO for disease gene expression data for Childhood Acute Megakaryoblastic Leukemia.

Pathways for Childhood Acute Megakaryoblastic Leukemia

Pathways related to Childhood Acute Megakaryoblastic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.86 KMT2A ITGA2B GP1BA GATA1

GO Terms for Childhood Acute Megakaryoblastic Leukemia

Biological processes related to Childhood Acute Megakaryoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-templated transcription GO:0045893 9.65 NUP98 KMT2A KDM5A GLIS2 GATA1
2 homeostasis of number of cells within a tissue GO:0048873 9.46 KMT2A GATA1
3 embryonic hemopoiesis GO:0035162 8.8 KMT2A GATA1

Sources for Childhood Acute Megakaryoblastic Leukemia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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