MCID: CHL158
MIFTS: 24

Childhood Acute Megakaryoblastic Leukemia

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Childhood Acute Megakaryoblastic Leukemia

MalaCards integrated aliases for Childhood Acute Megakaryoblastic Leukemia:

Name: Childhood Acute Megakaryoblastic Leukemia 12 17
Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080794
NCIt 50 C7972

Summaries for Childhood Acute Megakaryoblastic Leukemia

Disease Ontology : 12 An acute megakaryocytic leukemia that is characterized by fusion oncogenes involving transcriptional regulators in childhood.

MalaCards based summary : Childhood Acute Megakaryoblastic Leukemia, also known as pediatric non-down syndrome acute megakaryoblastic leukemia, is related to acute megakaryocytic leukemia and down syndrome. An important gene associated with Childhood Acute Megakaryoblastic Leukemia is CD36 (CD36 Molecule), and among its related pathways/superpathways are MicroRNAs in cancer and Senescence and Autophagy in Cancer.

Related Diseases for Childhood Acute Megakaryoblastic Leukemia

Diseases related to Childhood Acute Megakaryoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 acute megakaryocytic leukemia 30.9 IL3 CD36
2 down syndrome 10.4
3 leukemia, acute myeloid 10.4
4 leukemia 10.3
5 acute megakaryoblastic leukemia without down syndrome 10.2
6 acute megakaryoblastic leukemia in down syndrome 10.2
7 leukemia, acute monocytic 10.1
8 myelofibrosis 10.1
9 childhood acute myeloid leukemia 10.1
10 hematologic cancer 10.1
11 fibrosarcoma of bone 10.1
12 histiocytosis 10.1
13 childhood leukemia 10.1
14 monocytic leukemia 10.1
15 myeloid leukemia 10.1
16 47,xyy 10.1
17 acute monoblastic leukemia 10.1
18 chromosomal triplication 10.1
19 ring chromosome 10.1
20 juvenile arthritis 10.1 IL6 CD36
21 b-cell growth factor 10.1 IL6 IL3
22 stachybotrys chartarum 10.0 IL6 IL3
23 neutrophilia, hereditary 10.0 IL6 IL3
24 gingival fibromatosis 10.0 IL6 CD36
25 nasal cavity disease 10.0 IL6 IL3
26 plasmodium falciparum malaria 10.0 IL6 CD36
27 nose disease 10.0 IL6 IL3
28 chronic urticaria 10.0 IL6 IL3
29 keratoconjunctivitis 10.0 IL6 IL3
30 gingival overgrowth 10.0 IL6 CD36
31 thrombocytosis 10.0 IL6 IL3
32 gastroenteritis 10.0 IL6 IL3
33 gastrointestinal system benign neoplasm 10.0 MIR99A IL6
34 otosclerosis 10.0 IL6 CD36
35 mastocytosis 10.0 IL6 IL3
36 bronchial disease 9.9 IL6 IL3
37 cerebral arterial disease 9.9 MIR125B1 IL6
38 pleural disease 9.9 MIR125B1 IL6
39 autoimmune disease of gastrointestinal tract 9.9 MIR125B1 IL6
40 non-alcoholic steatohepatitis 9.9 IL6 CD36
41 leukocyte disease 9.9 IL6 IL3
42 inguinal hernia 9.9 IL6 CD36
43 blood platelet disease 9.8 IL6 IL3 CD36
44 bone disease 9.8 IL6 IL3 CD36
45 low grade glioma 9.8 MIR125B2 MIR125B1
46 peripheral vertigo 9.8 MIR125B2 MIR125B1
47 bone marrow cancer 9.8 IL6 IL3
48 primary hyperparathyroidism 9.7 IL6 CD36
49 connective tissue disease 9.7 MIR125B1 IL6 CD36
50 respiratory system disease 9.7 MIR99A MIR125B1 IL6

Graphical network of the top 20 diseases related to Childhood Acute Megakaryoblastic Leukemia:



Diseases related to Childhood Acute Megakaryoblastic Leukemia

Symptoms & Phenotypes for Childhood Acute Megakaryoblastic Leukemia

Drugs & Therapeutics for Childhood Acute Megakaryoblastic Leukemia

Search Clinical Trials , NIH Clinical Center for Childhood Acute Megakaryoblastic Leukemia

Genetic Tests for Childhood Acute Megakaryoblastic Leukemia

Anatomical Context for Childhood Acute Megakaryoblastic Leukemia

Publications for Childhood Acute Megakaryoblastic Leukemia

Articles related to Childhood Acute Megakaryoblastic Leukemia:

(show all 18)
# Title Authors PMID Year
1
Clinical Characteristics and Prognosis of 27 Patients with Childhood Acute Megakaryoblastic Leukemia. 61
32532951 2020
2
The changing scenario of non-Down syndrome acute megakaryoblastic leukemia in children. 61
31092368 2019
3
Outcome of Childhood Acute Megakaryoblastic Leukemia: Children's Cancer Hospital Egypt 57357 Experience. 61
30686774 2019
4
Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. 61
28112737 2017
5
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study. 61
26215111 2015
6
MiR-125b and miR-99a encoded on chromosome 21 co-regulate vincristine resistance in childhood acute megakaryoblastic leukemia. 61
25571789 2015
7
Mosaic Trisomy 21 and Trisomy 14 as Acquired Cytogenetic Abnormalities without GATA1 Mutation in A Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia. 61
23467713 2011
8
Ring/marker chromosome derived from chromosome 7 in childhood acute megakaryoblastic leukemia with monosomy 7. 61
20809201 2010
9
[Childhood acute megakaryoblastic leukemia]. 61
17605859 2007
10
CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. 61
17071479 2006
11
Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. 61
12649131 2003
12
Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience. 61
11389009 2001
13
Induction of the erythropoietin receptor gene and acquisition of responsiveness to erythropoietin by stem cell factor in HML/SE, a human leukemic cell line. 61
9642254 1998
14
Expression of MDR-1/P-glycoprotein in childhood acute megakaryoblastic leukemia cells. 61
8590843 1995
15
Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases. 61
8220128 1993
16
[Induction of complete remission in a case of drug-resistant childhood acute megakaryoblastic leukemia by combination of G-CSF and chemotherapy]. 61
1374487 1992
17
Differentiation induction of blast cells in two cases of childhood acute megakaryoblastic leukemia in vitro by interleukin-3 and interleukin-6: an ultrastructural cytochemical study. 61
1655816 1991
18
Childhood acute megakaryoblastic leukemia with internalization of hemic cells. 61
2285130 1990

Variations for Childhood Acute Megakaryoblastic Leukemia

Expression for Childhood Acute Megakaryoblastic Leukemia

Search GEO for disease gene expression data for Childhood Acute Megakaryoblastic Leukemia.

Pathways for Childhood Acute Megakaryoblastic Leukemia

GO Terms for Childhood Acute Megakaryoblastic Leukemia

Cellular components related to Childhood Acute Megakaryoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 9.13 MIR99A MIR125B2 MIR125B1
2 extracellular space GO:0005615 9.1 MIR99A MIR125B2 MIR125B1 IL6 IL3 CD36

Biological processes related to Childhood Acute Megakaryoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.75 MIR99A MIR125B2 MIR125B1
2 immune response GO:0006955 9.72 IL6 IL3 CD36
3 cytokine-mediated signaling pathway GO:0019221 9.67 IL6 IL3 CD36
4 defense response to Gram-positive bacterium GO:0050830 9.59 IL6 CD36
5 miRNA mediated inhibition of translation GO:0035278 9.58 MIR125B2 MIR125B1
6 positive regulation of interleukin-6 production GO:0032755 9.57 IL6 CD36
7 positive regulation of tumor necrosis factor production GO:0032760 9.56 IL6 CD36
8 negative regulation of tumor necrosis factor production GO:0032720 9.54 MIR125B2 MIR125B1
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IL6 IL3
10 NIK/NF-kappaB signaling GO:0038061 9.51 MIR125B2 MIR125B1
11 cellular response to interleukin-6 GO:0071354 9.48 MIR125B2 MIR125B1
12 positive regulation of keratinocyte differentiation GO:0045618 9.46 MIR125B2 MIR125B1
13 negative regulation of keratinocyte proliferation GO:0010839 9.43 MIR125B2 MIR125B1
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.43 IL6 IL3 CD36
15 cellular response to vitamin D GO:0071305 9.4 MIR125B2 MIR125B1
16 negative regulation of monocyte differentiation GO:0045656 9.37 MIR125B2 MIR125B1
17 positive regulation of glial cell proliferation GO:0060252 9.33 MIR125B2 MIR125B1 IL6
18 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.32 MIR125B2 MIR125B1
19 negative regulation of interleukin-6-mediated signaling pathway GO:0070104 9.13 MIR99A MIR125B2 MIR125B1
20 negative regulation of STAT cascade GO:1904893 8.8 MIR99A MIR125B2 MIR125B1

Molecular functions related to Childhood Acute Megakaryoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 8.8 MIR99A MIR125B2 MIR125B1

Sources for Childhood Acute Megakaryoblastic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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