Childhood Acute Megakaryoblastic Leukemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Childhood Acute Megakaryoblastic Leukemia

MalaCards integrated aliases for Childhood Acute Megakaryoblastic Leukemia:

Name: Childhood Acute Megakaryoblastic Leukemia ¹¹ ¹⁴ ¹⁶

Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Blood diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0080794

NCIt ⁴⁹ C7972

EFO ¹⁶ EFO_1001943

Sources

Summaries for Childhood Acute Megakaryoblastic Leukemia

Disease Ontology: ¹¹ An acute megakaryocytic leukemia that is characterized by fusion oncogenes involving transcriptional regulators in childhood.

MalaCards based summary: Childhood Acute Megakaryoblastic Leukemia, also known as pediatric non-down syndrome acute megakaryoblastic leukemia, is related to leukemia, acute monocytic and acute megakaryoblastic leukemia without down syndrome. An important gene associated with Childhood Acute Megakaryoblastic Leukemia is CBFA2T3 (CBFA2/RUNX1 Partner Transcriptional Co-Repressor 3), and among its related pathways/superpathways is Assembly of the pre-replicative complex.

Sources

Related Diseases for Childhood Acute Megakaryoblastic Leukemia

Diseases related to Childhood Acute Megakaryoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)

#	Related Disease	Score	Top Affiliating Genes
1	leukemia, acute monocytic	29.8	NUP98 KMT2A
2	acute megakaryoblastic leukemia without down syndrome	29.6	NUP98 KMT2A KDM5A GLIS2 CBFA2T3
3	myelodysplastic syndrome	29.5	NUP98 KMT2A GP1BA GATA1
4	childhood leukemia	29.5	NUP98 KMT2A GATA1 CBFA2T3
5	childhood acute myeloid leukemia	29.3	NUP98 KMT2A KDM5A GLIS2 CBFA2T3
6	acute megakaryocytic leukemia	29.1	NUP98 KMT2A KDM5A ITGA2B GP1BA GLIS2
7	leukemia, acute myeloid	29.0	NUP98 KMT2A KDM5A ITGA2B GLIS2 GATA1
8	down syndrome	10.5
9	leukemia	10.3
10	acute myeloid leukemia with recurrent genetic anomaly	10.3
11	acute megakaryoblastic leukemia in down syndrome	10.2
12	myelofibrosis	10.1
13	histiocytic sarcoma	10.1
14	hematologic cancer	10.1
15	fibrosarcoma of bone	10.1
16	histiocytosis	10.1
17	monocytic leukemia	10.1
18	acute monoblastic leukemia	10.1
19	ring chromosome	10.1
20	myeloid leukemia associated with down syndrome	10.0	GLIS2 GATA1 CBFA2T3
21	pseudo-von willebrand disease	10.0	GP1BA GATA1
22	fetal and neonatal alloimmune thrombocytopenia	10.0	ITGA2B GP1BA
23	autosomal dominant macrothrombocytopenia	10.0	ITGA2B GP1BA
24	gray platelet syndrome	10.0	ITGA2B GATA1
25	qualitative platelet defect	10.0	ITGA2B GP1BA
26	acquired thrombocytopenia	10.0	ITGA2B GP1BA
27	bleeding disorder, platelet-type, 11	10.0	ITGA2B GP1BA
28	carotid artery thrombosis	10.0	ITGA2B GP1BA
29	thrombasthenia	9.9	ITGA2B GP1BA
30	infective endocarditis	9.9	ITGA2B GP1BA
31	fetal hemoglobin quantitative trait locus 1	9.9	ITGA2B GATA1
32	primary thrombocytopenia	9.9	ITGA2B GP1BA
33	coronary thrombosis	9.9	ITGA2B GP1BA
34	thrombocytopenia due to platelet alloimmunization	9.9	ITGA2B GP1BA
35	acute erythroid leukemia	9.9	ITGA2B GATA1 CBFA2T3
36	von willebrand's disease	9.9	ITGA2B GP1BA
37	neonatal leukemia	9.9	KMT2A GATA1
38	beta-thalassemia major	9.9	ITGA2B GATA1
39	thrombocytopenic purpura, autoimmune	9.9	ITGA2B GP1BA
40	purpura	9.9	ITGA2B GP1BA
41	amegakaryocytic thrombocytopenia, congenital	9.8	ITGA2B GP1BA GATA1
42	bernard-soulier syndrome	9.8	ITGA2B GP1BA GATA1
43	glanzmann thrombasthenia 1	9.8	ITGA2B GP1BA
44	blood platelet disease	9.8	ITGA2B GP1BA GATA1
45	essential thrombocythemia	9.8	ITGA2B GP1BA GATA1
46	precursor t-cell acute lymphoblastic leukemia	9.7	NUP98 KMT2A
47	acute leukemia	9.7	NUP98 KMT2A GATA1
48	hemorrhagic disease	9.6	ITGA2B GP1BA
49	myeloid leukemia	9.6	NUP98 KMT2A KDM5A CBFA2T3
50	myeloproliferative syndrome, transient	9.1	KMT2A ITGA2B GP1BA GLIS2 GATA1 CBFA2T3

Graphical network of the top 20 diseases related to Childhood Acute Megakaryoblastic Leukemia:

Sources

Symptoms & Phenotypes for Childhood Acute Megakaryoblastic Leukemia

Sources

Drugs & Therapeutics for Childhood Acute Megakaryoblastic Leukemia

Search Clinical Trials, NIH Clinical Center for Childhood Acute Megakaryoblastic Leukemia

Sources

Genetic Tests for Childhood Acute Megakaryoblastic Leukemia

Sources

Anatomical Context for Childhood Acute Megakaryoblastic Leukemia

Sources

Publications for Childhood Acute Megakaryoblastic Leukemia

Articles related to Childhood Acute Megakaryoblastic Leukemia:

(show all 19)

#	Title	Authors	PMID	Year
1	Frequent detection of CBFA2T3::GLIS2 fusion and RAM-phenotype in pediatric non-Down syndrome acute megakaryoblastic leukemia: a possible novel relationship with aberrant cytoplasmic CD3 expression. ⁶²	Chen Wongworawat Y...Fisher KE	36346368	2022
2	Clinical Characteristics and Prognosis of 27 Patients with Childhood Acute Megakaryoblastic Leukemia. ⁶²	Qi H...Zhou G	32532951	2020
3	The changing scenario of non-Down syndrome acute megakaryoblastic leukemia in children. ⁶²	Masetti R...Pession A	31092368	2019
4	Outcome of Childhood Acute Megakaryoblastic Leukemia: Children's Cancer Hospital Egypt 57357 Experience. ⁶²	Maarouf N...Elhaddad A	30686774	2019
5	Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. ⁶²	de Rooij JD...Gruber TA	28112737	2017
6	Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study. ⁶²	Inaba H...Raimondi SC	26215111	2015
7	MiR-125b and miR-99a encoded on chromosome 21 co-regulate vincristine resistance in childhood acute megakaryoblastic leukemia. ⁶²	Kandi R...Gutti RK	25571789	2015
8	Mosaic Trisomy 21 and Trisomy 14 as Acquired Cytogenetic Abnormalities without GATA1 Mutation in A Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia. ⁶²	Xiao Y...Zhang YC	23467713	2011
9	Ring/marker chromosome derived from chromosome 7 in childhood acute megakaryoblastic leukemia with monosomy 7. ⁶²	Fujino H...Adachi S	20809201	2010
10	[Childhood acute megakaryoblastic leukemia]. ⁶²	Lei Q...Tang SQ	17605859	2007
11	CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. ⁶²	Savasan S...Ravindranath Y	17071479	2006
12	Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. ⁶²	Rainis L...Izraeli S	12649131	2003
13	Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience. ⁶²	Athale UH...Ribeiro RC	11389009	2001
14	Induction of the erythropoietin receptor gene and acquisition of responsiveness to erythropoietin by stem cell factor in HML/SE, a human leukemic cell line. ⁶²	Sato T...Nakahata T	9642254	1998
15	Expression of MDR-1/P-glycoprotein in childhood acute megakaryoblastic leukemia cells. ⁶²	Ota S...Tsuruo T	8590843	1995
16	Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases. ⁶²	Ribeiro RC...Crist WM	8220128	1993
17	[Induction of complete remission in a case of drug-resistant childhood acute megakaryoblastic leukemia by combination of G-CSF and chemotherapy]. ⁶²	Sugita K...Miyauchi J	1374487	1992
18	Differentiation induction of blast cells in two cases of childhood acute megakaryoblastic leukemia in vitro by interleukin-3 and interleukin-6: an ultrastructural cytochemical study. ⁶²	Miyauchi J...Shimizu K	1655816	1991
19	Childhood acute megakaryoblastic leukemia with internalization of hemic cells. ⁶²	Shimizu H...Fujimoto T	2285130	1990

Sources

Genes for Childhood Acute Megakaryoblastic Leukemia

Genes related to Childhood Acute Megakaryoblastic Leukemia (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CBFA2T3	CBFA2/RUNX1 Partner Transcriptional Co-Repressor 3	Protein Coding	6.9	DISEASES inferred ¹⁴
2	GLIS2	GLIS Family Zinc Finger 2	Protein Coding	6.85	DISEASES inferred ¹⁴
3	KDM5A	Lysine Demethylase 5A	Protein Coding	5.48	DISEASES inferred ¹⁴
4	NUP98	Nucleoporin 98 And 96 Precursor	Protein Coding	5.42	DISEASES inferred ¹⁴
5	GATA1	GATA Binding Protein 1	Protein Coding	5.34	DISEASES inferred ¹⁴
6	FAM53C	Family With Sequence Similarity 53 Member C	Protein Coding	5.06	DISEASES inferred ¹⁴
7	ZBTB47	Zinc Finger And BTB Domain Containing 47	Protein Coding	4.95	DISEASES inferred ¹⁴
8	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	4.82	DISEASES inferred ¹⁴
9	DLGAP1	DLG Associated Protein 1	Protein Coding	4.82	DISEASES inferred ¹⁴
10	KMT2A	Lysine Methyltransferase 2A	Protein Coding	4.76	DISEASES inferred ¹⁴
11	GP1BA	Glycoprotein Ib Platelet Subunit Alpha	Protein Coding	4.73	DISEASES inferred ¹⁴

Sources

Variations for Childhood Acute Megakaryoblastic Leukemia

Sources

Expression for Childhood Acute Megakaryoblastic Leukemia

Search GEO for disease gene expression data for Childhood Acute Megakaryoblastic Leukemia.

Sources

Pathways for Childhood Acute Megakaryoblastic Leukemia

Pathways related to Childhood Acute Megakaryoblastic Leukemia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Assembly of the pre-replicative complex ⁶⁶ Show member pathways DNA Replication ⁶⁶ DNA Replication Pre-Initiation ⁶⁶ RUNX1 regulates transcription of genes involved in differentiation of HSCs ⁶⁶ Transcriptional regulation by RUNX1 ⁶⁶	11.86	KMT2A ITGA2B GP1BA GATA1

Sources

GO Terms for Childhood Acute Megakaryoblastic Leukemia

Biological processes related to Childhood Acute Megakaryoblastic Leukemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of DNA-templated transcription	GO:0045893	9.65	NUP98 KMT2A KDM5A GLIS2 GATA1
2	homeostasis of number of cells within a tissue	GO:0048873	9.46	KMT2A GATA1
3	embryonic hemopoiesis	GO:0035162	8.8	KMT2A GATA1

Sources

Sources for Childhood Acute Megakaryoblastic Leukemia

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CHL158 MIFTS: 20	Childhood Acute Megakaryoblastic Leukemia Categories: Blood diseases, Cancer diseases	Data Licensing For inquiries, contact: [email protected]
Genes Related diseases Publications Expand all tables