Childhood Apraxia of Speech disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHL109 MIFTS: 32	Childhood Apraxia of Speech Categories: Rare diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Download Expand all tables

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Aliases & Classifications for Childhood Apraxia of Speech

MalaCards integrated aliases for Childhood Apraxia of Speech:

Name: Childhood Apraxia of Speech ⁵³ ⁵⁹

Speech and Language Disorder with Orofacial Dyspraxia ⁵³ ⁵⁹

Developmental Verbal Dyspraxia ⁵³ ⁵⁹

Cas ⁵³ ⁵⁹

Articulation Disorders, Developmental ⁷³

Developmental Apraxia of Speech ⁵³

Apraxia, Developmental Verbal ⁷³

Developmental Verbal Apraxia ⁵³

Apraxia, Articulatory ⁷³

Articulatory Apraxia ⁵³

Das ⁵³

Characteristics:

Orphanet epidemiological data:

⁵⁹

childhood apraxia of speech
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁹

Rare neurological diseases

External Ids:

Orphanet ⁵⁹ ORPHA209908

UMLS ⁷³ C0236828 C3495144 C0750927

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Summaries for Childhood Apraxia of Speech

NIH Rare Diseases : ⁵³ Childhood apraxia of speech occurs in children and is present from birth. It appears to be more common in boys than girls. Children with this condition have difficulty planning and producing the precise, refined, and specific movements of the tongue, lips, jaw, and palate that are necessary for intelligible speech. In many cases, the underlying cause of childhood apraxia of speech is unknown (idiopathic). Some cases are associated with a known neurological cause (such as intrauterine or early childhood stroke, infection, trauma, brain cancer or tumor resection, traumatic brain injury, etc.), and other cases occur as part of a complex neurobehavioral disorder (such as autism, epilepsy, fragile X syndrome, galactosemia, Rett syndrome, Prader-Willi syndrome or certain types of chromosome abnormalities). In some cases, researchers have found alterations (mutations) in the FOXP2 gene or loss of genetic material involving this gene. Treatment of childhood apraxia of speech involves speech therapy with a speech-language pathologist. Those with more severe cases will require more therapy than those with mild cases. The goal of therapy is to increase speech production and intelligibility. In some cases, augmentative and alternative forms of communication may be needed.

MalaCards based summary : Childhood Apraxia of Speech, also known as speech and language disorder with orofacial dyspraxia, is related to apraxia and specific language impairment, and has symptoms including aprosodia An important gene associated with Childhood Apraxia of Speech is FOXP2 (Forkhead Box P2). Affiliated tissues include brain and tongue.

CDC : ³ Bromobenzylcyanide (CA), Chloroacetophenone (CN), Chlorobenzylidenemalononitrile (CS), Chloropicrin (PS), Dibenzoxazepine (CR)

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Related Diseases for Childhood Apraxia of Speech

Diseases related to Childhood Apraxia of Speech via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)

#	Related Disease	Score	Top Affiliating Genes
1	apraxia	30.6	FOXP2 ZGRF1
2	specific language impairment	29.7	CNTNAP2 FOXP2
3	pervasive developmental disorder	29.5	CNTNAP2 FOXP2
4	richieri costa da silva syndrome	12.0
5	erythrokeratodermia variabilis et progressiva 1	11.9
6	foxp2-related speech and language disorders	11.8
7	autosomal dominant palmoplantar keratoderma and congenital alopecia	11.6
8	pancreatic cancer	11.3
9	gastric cancer	11.3
10	scott syndrome	11.3
11	esophageal cancer	11.2
12	spinocerebellar ataxia 36	11.2
13	autosomal recessive palmoplantar keratoderma and congenital alopecia	11.2
14	familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis	11.2
15	hepatocellular carcinoma	11.1
16	endometrial cancer	11.1
17	gallbladder cancer	11.0
18	myotonia with skeletal abnormalities and mental retardation	11.0
19	intellectual disability - hypoplastic corpus callosum - preauricular tag	11.0
20	hypomagnesemia 3, renal	11.0
21	carbonic anhydrase va deficiency	11.0
22	tracheal cancer	10.9
23	penile cancer	10.9
24	goiter, multinodular, cystic renal disease, and digital anomalies	10.9
25	orthostatic intolerance	10.9
26	daneman davy mancer syndrome	10.9
27	amyloidosis, hereditary, transthyretin-related	10.8
28	arthrogryposis, distal, type 1a	10.8
29	arthrogryposis, distal, type 5	10.8
30	acrocallosal syndrome	10.8
31	congenital disorder of glycosylation, type ia	10.8
32	occipital horn syndrome	10.8
33	congenital disorder of glycosylation, type id	10.8
34	congenital disorder of glycosylation, type ib	10.8
35	congenital disorder of glycosylation, type ih	10.8
36	congenital disorder of glycosylation, type ik	10.8
37	phosphohydroxylysinuria	10.8
38	brachyolmia type 3	10.8
39	cowden syndrome 1	10.8
40	proteus syndrome	10.8
41	neonatal stroke	10.8
42	galloway-mowat syndrome	10.8
43	liver angiosarcoma	10.8
44	bile duct carcinoma	10.8
45	palmoplantar keratoderma and congenital alopecia 1	10.7
46	palmoplantar keratoderma and congenital alopecia 2	10.7
47	carbonic anhydrase va deficiency, hyperammonemia due to	10.7
48	gastric fundus cancer	10.7
49	pylorus cancer	10.7
50	descending colon cancer	10.7

Graphical network of the top 20 diseases related to Childhood Apraxia of Speech:

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Symptoms & Phenotypes for Childhood Apraxia of Speech

UMLS symptoms related to Childhood Apraxia of Speech:

aprosodia

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Drugs & Therapeutics for Childhood Apraxia of Speech

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Stuttering and Apraxia of Speech: the Efficacy of an Intervention Program	Completed	NCT01097161	Not Applicable
2	Treating Childhood Apraxia of Speech	Recruiting	NCT03238677	Not Applicable

Search NIH Clinical Center for Childhood Apraxia of Speech

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Genetic Tests for Childhood Apraxia of Speech

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Anatomical Context for Childhood Apraxia of Speech

MalaCards organs/tissues related to Childhood Apraxia of Speech:

⁴¹

Brain, Tongue

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Publications for Childhood Apraxia of Speech

Articles related to Childhood Apraxia of Speech:

(show top 50) (show all 96)

#	Title	Authors	Year
1	Treating Childhood Apraxia of Speech With the Kaufman Speech to Language Protocol: A Phase I Pilot Study. ( 29625432 )	Gomez M....Purcell A.	2018
2	Interventions for childhood apraxia of speech. ( 29845607 )	Morgan A.T....LiAcgeois F.J.	2018
3	Model-Driven Treatment of Childhood Apraxia of Speech: Positive Effects of the Speech Motor Learning Approach. ( 29222568 )	van der Merwe A....Steyn M.	2018
4	Poor Speech Perception Is Not a Core Deficit of Childhood Apraxia of Speech: Preliminary Findings. ( 29450502 )	Zuk J....Hogan T.P.	2018
5	A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: III. Theoretical Coherence of the Pause Marker with Speech Processing Deficits in Childhood Apraxia of Speech. ( 28384751 )	Shriberg L.D....Wilson D.L.	2017
6	Parental experiences and perceptions related to childhood apraxia of speech: Focus on functional implications. ( 28786692 )	Rusiewicz H.L....Ptakowski T.	2017
7	A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: II. Validity Studies of the Pause Marker. ( 28384803 )	Shriberg L.D....Wilson D.L.	2017
8	Parent experiences of variations in service delivery of Rapid Syllable Transition (ReST) treatment for childhood apraxia of speech. ( 28534689 )	Thomas D.C....Bricker-Katz G.	2017
9	Changes in movement transitions across a practice period in childhood apraxia of speech. ( 29281317 )	Grigos M.I....Case J.	2017
10	A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: IV. The Pause Marker Index. ( 28384662 )	Shriberg L.D....Wilson D.L.	2017
11	Sequential processing deficit as a shared persisting biomarker in dyslexia and childhood apraxia of speech. ( 28933620 )	Peter B....Stoel-Gammon C.	2017
12	Speech Inconsistency in Children With Childhood Apraxia of Speech, Language Impairment, and Speech Delay: Depends on the Stimuli. ( 28395359 )	Iuzzini-Seigel J....GREEN J.R.	2017
13	Combined clinician-parent delivery of rapid syllable transition (ReST) treatment for childhood apraxia of speech. ( 28443686 )	Thomas D.C....Ballard K.J.	2017
14	The Effect of Hand Gesture Cues Within the Treatment of /r/ for a College-Aged Adult With Persisting Childhood Apraxia of Speech. ( 29114768 )	Rusiewicz H.L....Rivera J.L.	2017
15	Variable Practice to Enhance Speech Learning in Ultrasound Biofeedback Treatment for Childhood Apraxia of Speech: A Single Case Experimental Study. ( 28715554 )	Preston J.L....Maas E.	2017
16	A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: I. Development and Description of the Pause Marker. ( 28384779 )	Shriberg L.D....Wilson D.L.	2017
17	A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: Introduction. ( 28384695 )	Shriberg L.D....Wilson D.L.	2017
18	Expanding the phenotypic profile of Kleefstra syndrome: A female with low-average intelligence and childhood apraxia of speech. ( 26833960 )	Samango-Sprouse C....Gropman A.	2016
19	Childhood apraxia of speech: A survey of praxis and typical speech characteristics. ( 27241138 )	Malmenholt A....McAllister A.	2016
20	Neuroanatomical correlates of childhood apraxia of speech: A connectomic approach. ( 27882295 )	Fiori S....Chilosi A.	2016
21	Articulatory Control in Childhood Apraxia of Speech in a Novel Word-Learning Task. ( 27750297 )	Case J....Grigos M.I.	2016
22	Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech. ( 27120335 )	Peter B....Raskind W.H.	2016
23	Cognitive, Linguistic, and Motor Abilities in a Multigenerational Family with Childhood Apraxia of Speech. ( 27707700 )	Carrigg B....Ballard K.J.	2016
24	A highly penetrant form of childhood apraxia of speech due to deletion of 16p11.2. ( 26763793 )	Fedorenko E....Kanwisher N.	2016
25	Telehealth delivery of Rapid Syllable Transitions (ReST) treatment for childhood apraxia of speech. ( 27161038 )	Thomas D.C....Lincoln M.	2016
26	A Randomized Controlled Trial for children with Childhood Apraxia of Speech comparing Rapid Syllable Transition Treatment and the Nuffield Dyspraxia Programme (3rd edition). ( 25807891 )	Murray E....Ballard K.J.	2015
27	Simultaneous natural speech and AAC interventions for children with childhood apraxia of speech: lessons from a speech-language pathologist focus group. ( 25664542 )	Oommen E.R....McCarthy J.W.	2015
28	A highly penetrant form of childhood apraxia of speech due to deletion of 16p11.2. ( 26173965 )	Fedorenko E....Kanwisher N.	2015
29	Oral Articulatory Control in Childhood Apraxia of Speech. ( 25951237 )	Grigos M.I....Lu Y.	2015
30	Reliance on auditory feedback in children with childhood apraxia of speech. ( 25662298 )	Iuzzini-Seigel J....GREEN J.R.	2015
31	Motor functions and adaptive behaviour in children with childhood apraxia of speech. ( 25740430 )	TA1kel A.9....Eliasson A.C.	2015
32	The role of candidate-gene CNTNAP2 in childhood apraxia of speech and specific language impairment. ( 26097074 )	Centanni T.M....Hogan T.P.	2015
33	Treatment intensity and childhood apraxia of speech. ( 25581372 )	Namasivayam A.K....van Lieshout P.	2015
34	Behavioral and neurobiological correlates of childhood apraxia of speech in Italian children. ( 26552038 )	Chilosi A.M....Cioni G.	2015
35	Tools for the assessment of childhood apraxia of speech. ( 26691627 )	Gubiani M.B....Keske-Soares M.	2015
36	Volubility, consonant, and syllable characteristics in infants and toddlers later diagnosed with childhood apraxia of speech: A pilot study. ( 25934424 )	Overby M....Caspari S.S.	2015
37	Differential diagnosis of children with suspected childhood apraxia of speech. ( 25480674 )	Murray E....Ballard K.J.	2015
38	Cognitive functions in Childhood Apraxia of Speech. ( 25675214 )	Nijland L....Maassen B.	2015
39	Neurophysiology of speech differences in childhood apraxia of speech. ( 25090016 )	Preston J.L....Landi N.	2014
40	Motor-based intervention protocols in treatment of childhood apraxia of speech (CAS). ( 25313348 )	Maas E....Stoeckel R.	2014
41	Using randomized variable practice in the treatment of childhood apraxia of speech. ( 25017177 )	Skelton S.L....Hagopian A.L.	2014
42	Rapid Syllable Transitions (ReST) treatment for Childhood Apraxia of Speech: The effect of lower dose-Frequency. ( 25052390 )	Thomas D.C....Ballard K.J.	2014
43	Orthographically sensitive treatment for dysprosody in children with childhood apraxia of speech using ReST intervention. ( 24694312 )	McCabe P....Arciuli J.	2014
44	Impact of speech-generating devices on the language development of a child with childhood apraxia of speech: a case study. ( 24773213 )	LA1ke C.	2014
45	A systematic review of treatment outcomes for children with childhood apraxia of speech. ( 24686844 )	Murray E....Ballard K.J.	2014
46	Treating speech subsystems in childhood apraxia of speech with tactual input: the PROMPT approach. ( 23813194 )	Dale P.S....Hayden D.A.	2013
47	Deficits in sequential processing manifest in motor and linguistic tasks in a multigenerational family with childhood apraxia of speech. ( 23339324 )	Peter B....Raskind W.H.	2013
48	Whole-exome sequencing supports genetic heterogeneity in childhood apraxia of speech. ( 24083349 )	Worthey E.A....Shriberg L.D.	2013
49	12p13.33 microdeletion including ELKS/ERC1, a new locus associated with childhood apraxia of speech. ( 22713806 )	Thevenon J....Faivre L.	2013
50	Childhood Apraxia of Speech (CAS) in two patients with 16p11.2 microdeletion syndrome. ( 22909774 )	Raca G....Shriberg L.D.	2013

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Genes for Childhood Apraxia of Speech

Genes related to Childhood Apraxia of Speech (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FOXP2	Forkhead Box P2	Protein Coding	750	Pathogenic ⁶ Causative germline mutation ⁵⁹
2	CNTNAP2	Contactin Associated Protein Like 2	Protein Coding	17.33	GeneCards inferred via : Publications (show sections)
3	ERC1	ELKS/RAB6-Interacting/CAST Family Member 1	Protein Coding	17.33	GeneCards inferred via : Publications (show sections)
4	ZGRF1	Zinc Finger GRF-Type Containing 1	Protein Coding	17.33	GeneCards inferred via : Publications (show sections)

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Variations for Childhood Apraxia of Speech

ClinVar genetic disease variations for Childhood Apraxia of Speech:

⁶

(show top 50) (show all 210)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	FOXP2	NM_014491.3(FOXP2): c.1658G> A (p.Arg553His)	single nucleotide variant	Pathogenic	rs121908377	GRCh37	Chromosome 7, 114302130: 114302130
2	FOXP2	NM_014491.3(FOXP2): c.1658G> A (p.Arg553His)	single nucleotide variant	Pathogenic	rs121908377	GRCh38	Chromosome 7, 114662075: 114662075
3	FOXP2	NM_014491.3(FOXP2): c.982C> T (p.Arg328Ter)	single nucleotide variant	Pathogenic	rs121908378	GRCh37	Chromosome 7, 114282671: 114282671
4	FOXP2	NM_014491.3(FOXP2): c.982C> T (p.Arg328Ter)	single nucleotide variant	Pathogenic	rs121908378	GRCh38	Chromosome 7, 114642616: 114642616
5	FOXP2	NM_014491.3(FOXP2): c.741C> T (p.Gly247=)	single nucleotide variant	Benign	rs61732741	GRCh37	Chromosome 7, 114271726: 114271726
6	FOXP2	NM_014491.3(FOXP2): c.741C> T (p.Gly247=)	single nucleotide variant	Benign	rs61732741	GRCh38	Chromosome 7, 114631671: 114631671
7	FOXP2	NM_014491.3(FOXP2): c.1770-4dupT	duplication	Conflicting interpretations of pathogenicity	rs398005923	GRCh37	Chromosome 7, 114303501: 114303501
8	FOXP2	NM_014491.3(FOXP2): c.1770-4dupT	duplication	Conflicting interpretations of pathogenicity	rs398005923	GRCh38	Chromosome 7, 114663446: 114663446
9	FOXP2	NM_014491.3(FOXP2): c.50A> T (p.Gln17Leu)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs201649896	GRCh37	Chromosome 7, 114066616: 114066616
10	FOXP2	NM_014491.3(FOXP2): c.50A> T (p.Gln17Leu)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs201649896	GRCh38	Chromosome 7, 114426561: 114426561
11	FOXP2	GRCh37/hg19 7q31.1(chr7: 113925160..113934427)x1	copy number loss	Benign		GRCh37	Chromosome 7, 113925160: 113934427
12	FOXP2	GRCh37/hg19 7q31.1(chr7: 113925160..113934427)x1	copy number loss	Benign		GRCh38	Chromosome 7, 114285105: 114294372
13	FOXP2	NM_014491.3(FOXP2): c.1266+8C> T	single nucleotide variant	Likely benign	rs139649711	GRCh37	Chromosome 7, 114294072: 114294072
14	FOXP2	NM_014491.3(FOXP2): c.1266+8C> T	single nucleotide variant	Likely benign	rs139649711	GRCh38	Chromosome 7, 114654017: 114654017
15	FOXP2	t(7;13)(q31.1;q13.2)	Translocation	Pathogenic		GRCh38	Chromosome 13, 33833892: 33833897
16	FOXP2	t(7;13)(q31.1;q13.2)	Translocation	Pathogenic		GRCh38	Chromosome 7, 114637586: 114637591
17	IMMP2L; LRRN3	NC_000007.13: g.109049659_111130658del2081000	deletion	Pathogenic		GRCh37	Chromosome 7, 109049659: 111130658
18	FOXP2	NC_000007.12: g.111781517_120142536del	deletion	Pathogenic		NCBI36	Chromosome 7, 111781517: 120142536
19	FOXP2	7q31.1-q31.2, 6.5 Mb deletion	deletion	Pathogenic		NCBI36	Chromosome 7, 108290244: 114759023
20	FOXP2	NM_148898.3(FOXP2): c.570_581dupACAACAGCAGCA (p.Gln216_His217insGlnGlnGlnGln)	duplication	Pathogenic	rs879253770	GRCh37	Chromosome 7, 114269958: 114269969
21	FOXP2	NM_148898.3(FOXP2): c.570_581dupACAACAGCAGCA (p.Gln216_His217insGlnGlnGlnGln)	duplication	Pathogenic	rs879253770	GRCh38	Chromosome 7, 114629903: 114629914
22	FOXP2	NM_014491.3(FOXP2): c.1168_1169delCA (p.Gln390ValfsTer7)	deletion	Pathogenic	rs879253771	GRCh37	Chromosome 7, 114292331: 114292332
23	FOXP2	NM_014491.3(FOXP2): c.1168_1169delCA (p.Gln390ValfsTer7)	deletion	Pathogenic	rs879253771	GRCh38	Chromosome 7, 114652276: 114652277
24	FOXP2	NM_014491.3(FOXP2): c.1789A> C (p.Asn597His)	single nucleotide variant	Uncertain significance	rs766476648	GRCh37	Chromosome 7, 114303524: 114303524
25	FOXP2	NM_014491.3(FOXP2): c.1789A> C (p.Asn597His)	single nucleotide variant	Uncertain significance	rs766476648	GRCh38	Chromosome 7, 114663469: 114663469
26	FOXP2	t(3;7)(q23;q31.2)	Translocation	Pathogenic
27	FOXP2	t(5;7)(q22;q31.2)	Translocation	Pathogenic
28	FOXP2	7q31.1-q31.3, 14.8 Mb deletion	deletion	Pathogenic
29	FOXP2	7q31.1-q31.2, 1.57 Mb deletion	deletion	Pathogenic
30	FOXP2	7q31.1-q31.2, 9.1 Mb deletion	deletion	Pathogenic
31	FOXP2	7q31.1-q31.3, 16 Mb deletion	deletion	Pathogenic
32	FOXP2	7q31.1-q31.3, 11 Mb deletion	deletion	Pathogenic
33	FOXP2	7q31.1-q31.3, 15 Mb deletion	deletion	Pathogenic
34	FOXP2	NC_000007.12: g.112946520_114520576del	deletion	Pathogenic		NCBI36	Chromosome 7, 112946520: 114520576
35	FOXP2	7q31.2-q32, 13 Mb deletion	deletion	Pathogenic
36	FOXP2	7q31.2-q32, 14 Mb deletion	deletion	Pathogenic
37	FOXP2	7q31.2-q32, 15 Mb deletion	deletion	Pathogenic
38	FOXP2	7q31.2-q32, 26 Mb deletion	deletion	Pathogenic
39	FOXP2	7q22-q31.3 deletion (15 Mb)	deletion	Pathogenic
40	FOXP2	7q22-q31.33, 22 Mb deletion	deletion	Pathogenic
41	FOXP2	NC_000007.13	undetermined variant	Pathogenic
42	FOXP2	Uniparental disomy of chromosome 7	complex	Pathogenic
43	FOXP2	NM_014491.3(FOXP2): c.1591T> C (p.Tyr531His)	single nucleotide variant	Pathogenic	rs879253772	GRCh37	Chromosome 7, 114299672: 114299672
44	FOXP2	NM_014491.3(FOXP2): c.1591T> C (p.Tyr531His)	single nucleotide variant	Pathogenic	rs879253772	GRCh38	Chromosome 7, 114659617: 114659617
45	FOXP2	NM_014491.3(FOXP2): c.-335A> G	single nucleotide variant	Uncertain significance	rs531957198	GRCh38	Chromosome 7, 114415036: 114415036
46	FOXP2	NM_014491.3(FOXP2): c.-335A> G	single nucleotide variant	Uncertain significance	rs531957198	GRCh37	Chromosome 7, 114055091: 114055091
47	FOXP2	NM_014491.3(FOXP2): c.-99G> A	single nucleotide variant	Benign	rs116320717	GRCh38	Chromosome 7, 114415272: 114415272
48	FOXP2	NM_014491.3(FOXP2): c.-99G> A	single nucleotide variant	Benign	rs116320717	GRCh37	Chromosome 7, 114055327: 114055327
49	FOXP2	NM_014491.3(FOXP2): c.-16G> A	single nucleotide variant	Uncertain significance	rs886061914	GRCh38	Chromosome 7, 114415355: 114415355
50	FOXP2	NM_014491.3(FOXP2): c.-16G> A	single nucleotide variant	Uncertain significance	rs886061914	GRCh37	Chromosome 7, 114055410: 114055410

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Expression for Childhood Apraxia of Speech

Search GEO for disease gene expression data for Childhood Apraxia of Speech.

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Pathways for Childhood Apraxia of Speech

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GO Terms for Childhood Apraxia of Speech

Biological processes related to Childhood Apraxia of Speech according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cerebral cortex development	GO:0021987	8.96	CNTNAP2 FOXP2
2	vocal learning	GO:0042297	8.62	CNTNAP2 FOXP2

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