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CAS
MCID: CHL109
MIFTS: 44

Childhood Apraxia of Speech (CAS)

Categories: Neuronal diseases, Oral diseases, Rare diseases, Smell/Taste diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes
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Aliases & Classifications for Childhood Apraxia of Speech

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MalaCards integrated aliases for Childhood Apraxia of Speech:

Name: Childhood Apraxia of Speech 20 58
Developmental Verbal Dyspraxia 20 58 6
Speech and Language Disorder with Orofacial Dyspraxia 20 58
Cas 20 58
Articulation Disorders, Developmental 70
Developmental Apraxia of Speech 20
Apraxia, Developmental Verbal 70
Developmental Verbal Apraxia 20
Apraxia, Articulatory 70
Articulatory Apraxia 20
Das 20

Characteristics:

Orphanet epidemiological data:

58
childhood apraxia of speech
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Smell/Taste diseases Oral diseases
See all MalaCards categories (disease lists)
Orphanet: 58  
Rare neurological diseases


External Ids:

Orphanet 58 ORPHA209908
UMLS 70 C0236828 C0750927 C3495144
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Summaries for Childhood Apraxia of Speech

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GARD : 20 Childhood apraxia of speech occurs in children and is present from birth. It appears to be more common in boys than girls. Children with this condition have difficulty planning and producing the precise, refined, and specific movements of the tongue, lips, jaw, and palate that are necessary for intelligible speech. In many cases, the underlying cause of childhood apraxia of speech is unknown (idiopathic). Some cases are associated with a known neurological cause (such as intrauterine or early childhood stroke, infection, trauma, brain cancer or tumor resection, traumatic brain injury, etc.), and other cases occur as part of a complex neurobehavioral disorder (such as autism, epilepsy, fragile X syndrome, galactosemia, Rett syndrome, Prader-Willi syndrome or certain types of chromosome abnormalities ). In some cases, researchers have found alterations ( mutations ) in the FOXP2 gene or loss of genetic material involving this gene. Treatment of childhood apraxia of speech involves speech therapy with a speech-language pathologist. Those with more severe cases will require more therapy than those with mild cases. The goal of therapy is to increase speech production and intelligibility. In some cases, augmentative and alternative forms of communication may be needed.

MalaCards based summary : Childhood Apraxia of Speech, also known as developmental verbal dyspraxia, is related to apraxia and speech disorder, and has symptoms including aprosodia An important gene associated with Childhood Apraxia of Speech is FOXP2 (Forkhead Box P2). Affiliated tissues include tongue, caudate nucleus and cortex, and related phenotypes are dysarthria and specific learning disability

Wikipedia : 73 Developmental verbal dyspraxia (DVD), also known as childhood apraxia of speech (CAS) and developmental... more...

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Related Diseases for Childhood Apraxia of Speech

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Diseases related to Childhood Apraxia of Speech via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 636)
# Related Disease Score Top Affiliating Genes
1 apraxia 30.9 FOXP2 ERC1 CNTNAP2
2 speech disorder 30.7 FOXP2 CNTNAP2
3 articulation disorder 30.0 FOXP2 CNTNAP2
4 specific language impairment 30.0 FOXP2 CNTNAP2
5 speech and communication disorders 30.0 FOXP2 CNTNAP2
6 stuttering 29.6 FOXP2 CNTNAP2
7 dyslexia 29.6 FOXP2 CNTNAP2
8 pervasive developmental disorder 29.6 FOXP2 CNTNAP2
9 autism spectrum disorder 29.4 FOXP2 ERC1 CNTNAP2
10 benign epilepsy with centrotemporal spikes 29.3 FOXP2 CNTNAP2
11 learning disability 29.0 FOXP2 CNTNAP2
12 palmoplantar keratoderma and congenital alopecia 2 11.0
13 cold agglutinin disease 11.0
14 occipital horn syndrome 10.9
15 adenoma 10.8
16 hepatocellular adenoma 10.6
17 keratosis 10.5
18 48,xyyy 10.5
19 agnosia 10.5
20 agenesis of corpus callosum, cardiac, ocular, and genital syndrome 10.5
21 foxp2-related speech and language disorders 10.5
22 squamous cell papilloma 10.5
23 papilloma 10.5
24 rheumatoid arthritis 10.4
25 carotid stenosis 10.4
26 tremor 10.3
27 arthritis 10.3
28 autism 10.3
29 dysphasia, familial developmental 10.3
30 grin2a-related speech disorders and epilepsy 10.3
31 primary progressive apraxia of speech 10.3
32 breast fibroadenoma 10.3
33 adenocarcinoma 10.3
34 ataxia and polyneuropathy, adult-onset 10.3
35 cholangiocarcinoma 10.3
36 intrahepatic cholangiocarcinoma 10.3
37 pheochromocytoma 10.2
38 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
39 adrenal gland pheochromocytoma 10.2
40 hepatoblastoma 10.2
41 expressive language disorder 10.2
42 seizure disorder 10.2
43 angiosarcoma 10.2
44 hemangioma 10.2
45 methemoglobinemia 10.2
46 hemosiderosis 10.2
47 hyperparathyroidism 10.1
48 fibroma 10.1
49 benign mesothelioma 10.1
50 fibrosarcoma 10.1

Graphical network of the top 20 diseases related to Childhood Apraxia of Speech:



Diseases related to Childhood Apraxia of Speech
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Symptoms & Phenotypes for Childhood Apraxia of Speech

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Human phenotypes related to Childhood Apraxia of Speech:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dysarthria 58 31 frequent (33%) Frequent (79-30%) HP:0001260
2 specific learning disability 58 31 frequent (33%) Frequent (79-30%) HP:0001328
3 speech apraxia 58 31 frequent (33%) Frequent (79-30%) HP:0011098
4 expressive language delay 58 31 frequent (33%) Frequent (79-30%) HP:0002474
5 poor fine motor coordination 58 31 frequent (33%) Frequent (79-30%) HP:0007010
6 incomprehensible speech 58 31 frequent (33%) Frequent (79-30%) HP:0002546
7 poor speech 58 31 frequent (33%) Frequent (79-30%) HP:0002465
8 grammar-specific speech disorder 58 31 frequent (33%) Frequent (79-30%) HP:0006977
9 abnormal speech prosody 58 31 frequent (33%) Frequent (79-30%) HP:0031434
10 receptive language delay 58 31 frequent (33%) Frequent (79-30%) HP:0010863
11 delayed social development 58 31 occasional (7.5%) Occasional (29-5%) HP:0012434
12 feeding difficulties 58 31 occasional (7.5%) Occasional (29-5%) HP:0011968
13 drooling 58 31 occasional (7.5%) Occasional (29-5%) HP:0002307
14 caudate atrophy 58 31 occasional (7.5%) Occasional (29-5%) HP:0002340
15 poor gross motor coordination 58 31 occasional (7.5%) Occasional (29-5%) HP:0007015
16 high, narrow palate 58 31 very rare (1%) Very rare (<4-1%) HP:0002705
17 overfolded helix 58 31 very rare (1%) Very rare (<4-1%) HP:0000396
18 submucous cleft hard palate 58 31 very rare (1%) Very rare (<4-1%) HP:0000176
19 autistic behavior 58 31 very rare (1%) Very rare (<4-1%) HP:0000729
20 horizontal eyebrow 58 31 very rare (1%) Very rare (<4-1%) HP:0011228
21 neurological speech impairment 58 Very frequent (99-80%)
22 delayed speech and language development 58 Very frequent (99-80%)
23 abnormal caudate nucleus morphology 58 Occasional (29-5%)

UMLS symptoms related to Childhood Apraxia of Speech:


aprosodia

GenomeRNAi Phenotypes related to Childhood Apraxia of Speech according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00236-A-1 9.02 RFC3
2 Decreased homologous recombination repair frequency GR00236-A-2 9.02 RFC3 ZGRF1
3 Decreased homologous recombination repair frequency GR00236-A-3 9.02 RFC3 ZGRF1
Sources

Drugs & Therapeutics for Childhood Apraxia of Speech

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ASSIST: Child Apraxia Speech Treatment Recruiting NCT03903120 Phase 1
2 Treating Childhood Apraxia of Speech: Role of Biofeedback & Practice Distribution Recruiting NCT03238677
3 Childhood Apraxia of Speech: Neurobiological and Behavioural Markers and Experience Dependent Changes of Neural Connectivity Induced by Treatment Enrolling by invitation NCT04832503
4 A Randomized Control Trial of Motor-based Intervention for Childhood Apraxia of Speech Not yet recruiting NCT04642053

Search NIH Clinical Center for Childhood Apraxia of Speech

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Genetic Tests for Childhood Apraxia of Speech

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Anatomical Context for Childhood Apraxia of Speech

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MalaCards organs/tissues related to Childhood Apraxia of Speech:

40
Tongue, Caudate Nucleus, Cortex
Sources

Publications for Childhood Apraxia of Speech

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Articles related to Childhood Apraxia of Speech:

(show top 50) (show all 247)
# Title Authors PMID Year
1
Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech. 6 61
27120335 2016
2
Monoallelic expression of the human FOXP2 speech gene. 61 6
25422445 2015
3
Small intragenic deletion in FOXP2 associated with childhood apraxia of speech and dysarthria. 61 6
23918746 2013
4
Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization. 61 6
22766611 2012
5
The DISC1 promoter: characterization and regulation by FOXP2. 6 61
22434823 2012
6
Mosaic 7q31 deletion involving FOXP2 gene associated with language impairment. 6 61
22144704 2012
7
Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex. 61 6
20858596 2010
8
Deletion of 7q31.1 supports involvement of FOXP2 in language impairment: clinical report and review. 61 6
17330859 2007
9
Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia. 6 61
17033973 2006
10
Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. 6 61
15877281 2005
11
An extended family with a dominantly inherited speech disorder. 61 6
2332125 1990
12
Language impairment in a case of a complex chromosomal rearrangement with a breakpoint downstream of FOXP2. 6
26060509 2015
13
A chromosomal rearrangement in a child with severe speech and language disorder separates FOXP2 from a functional enhancer. 6
26300977 2015
14
Maternally and paternally inherited deletion of 7q31 involving the FOXP2 gene in two families. 6
22105961 2012
15
Phenotype of FOXP2 haploinsufficiency in a mother and son. 6
22106036 2012
16
Language features in a mother and daughter of a chromosome 7;13 translocation involving FOXP2. 6
19797137 2009
17
Speech, prosody, and voice characteristics of a mother and daughter with a 7;13 translocation affecting FOXP2. 6
16787893 2006
18
Speech and language impairment and oromotor dyspraxia due to deletion of 7q31 that involves FOXP2. 6
16470794 2006
19
A forkhead-domain gene is mutated in a severe speech and language disorder. 6
11586359 2001
20
The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder. 6
10880297 2000
21
Comparing global motor characteristics in children and adults with childhood apraxia of speech to a cerebellar stroke patient: evidence for the cerebellar hypothesis in a developmental motor speech disorder. 61
33327803 2021
22
Digitomotography in children with orofacial dysfunction (OFD, orofacial myofunctional disorders) and childhood apraxia of speech (CAS). 61
33797781 2021
23
Concurrent Validity Between Two Sound Sequencing Tasks Used to Identify Childhood Apraxia of Speech in School-Age Children. 61
33684299 2021
24
Procedural Learning, Grammar, and Motor Skills in Children With Childhood Apraxia of Speech, Speech Sound Disorder, and Typically Developing Speech. 61
33784194 2021
25
Autism-Centered Therapy for Childhood Apraxia of Speech (ACT4CAS): A Single-Case Experimental Design Study. 61
33684309 2021
26
Differential Diagnosis of Childhood Apraxia of Speech Compared to Other Speech Sound Disorders: A Systematic Review. 61
33151751 2021
27
Self-limited focal epilepsy and childhood apraxia of speech with WAC pathogenic variants. 61
33387902 2021
28
Re-Evaluating Evidence for Best Practice in Paediatric Speech-Language Pathology. 61
31940655 2021
29
Speech in children with cerebral palsy. 61
32588921 2020
30
Vowel variability and contrast in Childhood Apraxia of Speech: acoustics and articulation. 61
33322970 2020
31
Application of childhood apraxia of speech clinical markers to French-speaking children: A preliminary study. 61
33666129 2020
32
Simplification of syllable structure in childhood apraxia of speech: a 2-year follow-up French case study. 61
33305632 2020
33
Autism Spectrum Disorder and Childhood Apraxia of Speech: Early Language-Related Hallmarks across Structural MRI Study. 61
33322765 2020
34
Feature-driven classification reveals potential comorbid subtypes within childhood apraxia of speech. 61
33187500 2020
35
A Framework of Motoric Complexity: An Investigation in Children With Typical and Impaired Speech Development. 61
32946304 2020
36
Differential Diagnosis of Apraxia of Speech in Children and Adults: A Scoping Review. 61
32783767 2020
37
Factor analysis of signs of childhood apraxia of speech. 61
32877838 2020
38
The influence of type of feedback during tablet-based delivery of intensive treatment for childhood apraxia of speech. 61
32693310 2020
39
A retrospective video analysis of canonical babbling and volubility in infants later diagnosed with childhood apraxia of speech. 61
31661338 2020
40
Speech and language development in children with 49,XXXXY syndrome. 61
32725750 2020
41
Severe childhood speech disorder: Gene discovery highlights transcriptional dysregulation. 61
32345733 2020
42
The Applicability of the Clinical Features of English Childhood Apraxia of Speech to Cantonese: A Modified Delphi Survey. 61
32097033 2020
43
GATAD2B-associated neurodevelopmental disorder (GAND): clinical and molecular insights into a NuRD-related disorder. 61
31949314 2020
44
Look at Mummy: challenges in training parents to deliver a home treatment program for childhood apraxia of speech in a rural Canadian community. 61
32343906 2020
45
Dynamic Temporal and Tactile Cueing: A Treatment Strategy for Childhood Apraxia of Speech. 61
31846588 2020
46
Lexical stress in childhood apraxia of speech: acoustic and kinematic findings. 61
30744428 2020
47
Protocol for the Connected Speech Transcription of Children with Speech Disorders: An Example from Childhood Apraxia of Speech. 61
31269497 2020
48
The Language Development Via FOXP2 in Autism Spectrum Disorder: A Review. 61
32912122 2020
49
Use of Transcription when Assessing Children's Speech: Australian Speech-Language Pathologists' Practices, Challenges, and Facilitators. 61
31597152 2020
50
Speech, language, and feeding phenotypes of SATB2-associated syndrome. 61
31392730 2019
Sources

Variations for Childhood Apraxia of Speech

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ClinVar genetic disease variations for Childhood Apraxia of Speech:

6 (show top 50) (show all 160)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 FOXP2 7q31.1-q31.3, 16 Mb deletion Deletion Pathogenic 242962 GRCh37:
GRCh38:
2 FOXP2 NC_000007.12:g.112946520_114520576del Deletion Pathogenic 242965 GRCh37:
GRCh38:
3 FOXP2 7q31.2-q32, 15 Mb deletion Deletion Pathogenic 242968 GRCh37:
GRCh38:
4 FOXP2 7q22-q31.33, 22 Mb deletion Deletion Pathogenic 242971 GRCh37:
GRCh38:
5 FOXP2 t(3;7)(q23;q31.2) Translocation Pathogenic 242953 GRCh37:
GRCh38:
6 FOXP2 7q31.1-q31.2, 1.57 Mb deletion Deletion Pathogenic 242960 GRCh37:
GRCh38:
7 FOXP2 7q31.1-q31.3, 11 Mb deletion Deletion Pathogenic 242963 GRCh37:
GRCh38:
8 FOXP2 NC_000007.12:g.111781517_120142536del Deletion Pathogenic 242957 GRCh37:
GRCh38:
9 FOXP2 t(5;7)(q22;q31.2) Translocation Pathogenic 242954 GRCh37:
GRCh38:
10 FOXP2 7q31.2-q32, 13 Mb deletion Deletion Pathogenic 242966 GRCh37:
GRCh38:
11 FOXP2 7q31.2-q32, 26 Mb deletion Deletion Pathogenic 242969 GRCh37:
GRCh38:
12 FOXP2 , RFC3 t(7;13)(q31.1;q13.2) Translocation Pathogenic 242955 GRCh37:
GRCh38: 7:114637586-114637591
13 FOXP2 7q31.1-q31.3, 15 Mb deletion Deletion Pathogenic 242964 GRCh37:
GRCh38:
14 FOXP2 NM_014491.4(FOXP2):c.1591T>C (p.Tyr531His) SNV Pathogenic 242975 rs879253772 GRCh37: 7:114299672-114299672
GRCh38: 7:114659617-114659617
15 FOXP2 7q31.1-q31.2, 9.1 Mb deletion Deletion Pathogenic 242961 GRCh37:
GRCh38:
16 FOXP2 Uniparental disomy of chromosome 7 Complex Pathogenic 242973 GRCh37:
GRCh38:
17 FOXP2 7q31.2-q32, 14 Mb deletion Deletion Pathogenic 242967 GRCh37:
GRCh38:
18 FOXP2 7q22-q31.3 deletion (15 Mb) Deletion Pathogenic 242970 GRCh37:
GRCh38:
19 overlap with 2 genes NC_000007.13:g.109049659_111130658del Deletion Pathogenic 242956 GRCh37: 7:109049659-111130658
GRCh38:
20 FOXP2 7q31.1-q31.3, 14.8 Mb deletion Deletion Pathogenic 242959 GRCh37:
GRCh38:
21 FOXP2 NM_014491.4(FOXP2):c.1426C>T (p.Arg476Ter) SNV Pathogenic 617625 rs1178491246 GRCh37: 7:114298280-114298280
GRCh38: 7:114658225-114658225
22 FOXP2 7q31.1-q31.2, 6.5 Mb deletion Deletion Pathogenic 242958 GRCh37:
GRCh38:
23 FOXP2 NM_014491.4(FOXP2):c.553C>T (p.Gln185Ter) SNV Pathogenic 807606 rs1584969672 GRCh37: 7:114270016-114270016
GRCh38: 7:114629961-114629961
24 overlap with 508 genes NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv Inversion Pathogenic 242972 GRCh37: 7:20954043-114556605
GRCh38:
25 FOXP2 NM_014491.4(FOXP2):c.1658G>A (p.Arg553His) SNV Pathogenic 5067 rs121908377 GRCh37: 7:114302130-114302130
GRCh38: 7:114662075-114662075
26 FOXP2 NM_014491.4(FOXP2):c.982C>T (p.Arg328Ter) SNV Pathogenic 5068 rs121908378 GRCh37: 7:114282671-114282671
GRCh38: 7:114642616-114642616
27 FOXP2 NM_014491.4(FOXP2):c.1168_1169del (p.Gln390fs) Deletion Pathogenic 242949 rs879253771 GRCh37: 7:114292330-114292331
GRCh38: 7:114652275-114652276
28 FOXP2 NM_014491.4(FOXP2):c.1266+18del Deletion Pathogenic 1031833 GRCh37: 7:114294080-114294080
GRCh38: 7:114654025-114654025
29 FOXP2 NM_014491.4(FOXP2):c.1769+2T>C SNV Likely pathogenic 431153 rs1135401820 GRCh37: 7:114302243-114302243
GRCh38: 7:114662188-114662188
30 ZGRF1 NM_018392.4(ZGRF1):c.4087G>A (p.Glu1363Lys) SNV Likely pathogenic 617843 rs76187047 GRCh37: 4:113506711-113506711
GRCh38: 4:112585555-112585555
31 ZGRF1 NM_018392.4(ZGRF1):c.142C>A (p.Leu48Met) SNV Likely pathogenic 617844 rs61745597 GRCh37: 4:113544993-113544993
GRCh38: 4:112623837-112623837
32 FOXP2 NM_014491.4(FOXP2):c.774A>G (p.Gln258=) SNV Uncertain significance 619976 GRCh37: 7:114271759-114271759
GRCh38: 7:114631704-114631704
33 FOXP2 NM_014491.4(FOXP2):c.892T>G (p.Ser298Ala) SNV Uncertain significance 908850 GRCh37: 7:114282581-114282581
GRCh38: 7:114642526-114642526
34 FOXP2 NM_014491.4(FOXP2):c.*366G>A SNV Uncertain significance 908906 GRCh37: 7:114330347-114330347
GRCh38: 7:114690292-114690292
35 FOXP2 NM_014491.4(FOXP2):c.*686A>G SNV Uncertain significance 908907 GRCh37: 7:114330667-114330667
GRCh38: 7:114690612-114690612
36 FOXP2 NM_014491.4(FOXP2):c.*2449A>G SNV Uncertain significance 908973 GRCh37: 7:114332430-114332430
GRCh38: 7:114692375-114692375
37 FOXP2 NM_014491.4(FOXP2):c.*2922T>G SNV Uncertain significance 908975 GRCh37: 7:114332903-114332903
GRCh38: 7:114692848-114692848
38 FOXP2 NM_014491.4(FOXP2):c.989+6T>A SNV Uncertain significance 909703 GRCh37: 7:114282684-114282684
GRCh38: 7:114642629-114642629
39 FOXP2 NM_014491.4(FOXP2):c.1344C>T (p.Thr448=) SNV Uncertain significance 909704 GRCh37: 7:114298198-114298198
GRCh38: 7:114658143-114658143
40 FOXP2 NM_014491.4(FOXP2):c.*1222G>C SNV Uncertain significance 909773 GRCh37: 7:114331203-114331203
GRCh38: 7:114691148-114691148
41 FOXP2 NM_014491.4(FOXP2):c.*1415A>T SNV Uncertain significance 909774 GRCh37: 7:114331396-114331396
GRCh38: 7:114691341-114691341
42 FOXP2 NM_014491.4(FOXP2):c.*1585T>C SNV Uncertain significance 909775 GRCh37: 7:114331566-114331566
GRCh38: 7:114691511-114691511
43 FOXP2 NM_014491.4(FOXP2):c.*1598G>A SNV Uncertain significance 909776 GRCh37: 7:114331579-114331579
GRCh38: 7:114691524-114691524
44 FOXP2 NM_014491.4(FOXP2):c.*3414G>C SNV Uncertain significance 909846 GRCh37: 7:114333395-114333395
GRCh38: 7:114693340-114693340
45 FOXP2 NM_014491.4(FOXP2):c.-290A>C SNV Uncertain significance 910570 GRCh37: 7:114055136-114055136
GRCh38: 7:114415081-114415081
46 FOXP2 NM_014491.4(FOXP2):c.*3643T>C SNV Uncertain significance 358672 rs536004145 GRCh37: 7:114333624-114333624
GRCh38: 7:114693569-114693569
47 FOXP2 NM_014491.4(FOXP2):c.183A>G (p.Ala61=) SNV Uncertain significance 358602 rs747126499 GRCh37: 7:114174686-114174686
GRCh38: 7:114534631-114534631
48 FOXP2 NM_014491.4(FOXP2):c.*1701A>C SNV Uncertain significance 358638 rs886061929 GRCh37: 7:114331682-114331682
GRCh38: 7:114691627-114691627
49 FOXP2 NM_014491.4(FOXP2):c.*1210A>G SNV Uncertain significance 358635 rs886061927 GRCh37: 7:114331191-114331191
GRCh38: 7:114691136-114691136
50 FOXP2 NM_014491.4(FOXP2):c.*708T>G SNV Uncertain significance 358632 rs886061925 GRCh37: 7:114330689-114330689
GRCh38: 7:114690634-114690634
Sources

Expression for Childhood Apraxia of Speech

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Search GEO for disease gene expression data for Childhood Apraxia of Speech.
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Pathways for Childhood Apraxia of Speech

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GO Terms for Childhood Apraxia of Speech

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Biological processes related to Childhood Apraxia of Speech according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cerebral cortex development GO:0021987 8.62 FOXP2 CNTNAP2
Sources

Sources for Childhood Apraxia of Speech

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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