MCID: CHL157
MIFTS: 33

Childhood B-Cell Acute Lymphoblastic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Childhood B-Cell Acute Lymphoblastic Leukemia

MalaCards integrated aliases for Childhood B-Cell Acute Lymphoblastic Leukemia:

Name: Childhood B-Cell Acute Lymphoblastic Leukemia 12 15
B-Cell Childhood Acute Lymphoblastic Leukemia 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0080146
NCIt 49 C9140

Summaries for Childhood B-Cell Acute Lymphoblastic Leukemia

Disease Ontology : 12 A childhood acute lymphoblastic leukemia that has material basis in B-cells.

MalaCards based summary : Childhood B-Cell Acute Lymphoblastic Leukemia, also known as b-cell childhood acute lymphoblastic leukemia, is related to childhood acute lymphocytic leukemia and leukemia, acute lymphoblastic 3. An important gene associated with Childhood B-Cell Acute Lymphoblastic Leukemia is RUNX1 (RUNX Family Transcription Factor 1), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Methylprednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include b cells, b lymphoblasts and liver, and related phenotypes are cellular and hematopoietic system

Related Diseases for Childhood B-Cell Acute Lymphoblastic Leukemia

Graphical network of the top 20 diseases related to Childhood B-Cell Acute Lymphoblastic Leukemia:



Diseases related to Childhood B-Cell Acute Lymphoblastic Leukemia

Symptoms & Phenotypes for Childhood B-Cell Acute Lymphoblastic Leukemia

MGI Mouse Phenotypes related to Childhood B-Cell Acute Lymphoblastic Leukemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 ARID5B CDKN2A CEBPE CRLF2 IKZF1 PAX5
2 hematopoietic system MP:0005397 9.8 ARID5B CDKN2A CEBPE CRLF2 IKZF1 PAX5
3 digestive/alimentary MP:0005381 9.72 ARID5B CDKN2A CEBPE CRLF2 IKZF1
4 immune system MP:0005387 9.7 ARID5B CDKN2A CEBPE CRLF2 IKZF1 PAX5
5 neoplasm MP:0002006 9.35 CDKN2A IKZF1 PAX5 PIP4K2A RUNX1
6 respiratory system MP:0005388 9.02 CDKN2A CEBPE CRLF2 IKZF1 RUNX1

Drugs & Therapeutics for Childhood B-Cell Acute Lymphoblastic Leukemia

Drugs for Childhood B-Cell Acute Lymphoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
2
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
3
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
4 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
7
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
8
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
9
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
10
Daunorubicin Approved Phase 3 20830-81-3 30323
11
Etoposide Approved Phase 3 33419-42-0 36462
12
Lenograstim Approved, Investigational Phase 3 135968-09-1
13
Ifosfamide Approved Phase 3 3778-73-2 3690
14
Sargramostim Approved, Investigational Phase 3 83869-56-1, 123774-72-1
15
Thiotepa Approved, Investigational Phase 3 52-24-4 5453
16
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
17
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492 6473866
18
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
19
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030 46835353
20
Vindesine Approved, Investigational Phase 3 59917-39-4, 53643-48-4 40839
21
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
22
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
23
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
24
leucovorin Approved Phase 3 58-05-9 6006 143
25
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
26
Pegaspargase Approved, Investigational Phase 3 130167-69-0
27
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
28
Mercaptopurine Approved Phase 3 50-44-2 667490
29
Thioguanine Approved Phase 3 154-42-7 2723601
30
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
31
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
32
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
33
Asparagine Approved, Investigational, Nutraceutical Phase 3 70-47-3 6267
34
Aspartic acid Approved, Nutraceutical Phase 3 56-84-8 5960
35
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
36
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
37 Methylprednisolone Acetate Phase 3
38 Analgesics Phase 3
39 Hydrocortisone 17-butyrate 21-propionate Phase 3
40 Hydrocortisone-17-butyrate Phase 3
41 Hydrocortisone hemisuccinate Phase 3
42 Neuroprotective Agents Phase 3
43 Etoposide phosphate Phase 3
44 Adjuvants, Immunologic Phase 3
45
Isophosphamide mustard Phase 3 0
46 Antifungal Agents Phase 3
47 Calcineurin Inhibitors Phase 3
48 Mineralocorticoids Phase 3
49 Tetrahydrofolates Phase 3
50 N-Methylaspartate Phase 3

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial of the I-BFM-SG for the Management of Childhood Non-B Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
2 High Risk B-Precursor Acute Lymphoblastic Leukemia Unknown status NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
3 The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
4 A Pilot Study of Dose Intensification of Methotrexate in Patients With Advanced-Stage (III/IV) Small Non-Cleaved Cell Non-Hodgkins Lymphoma and B-Cell All Completed NCT00005977 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;vincristine sulfate
5 A Randomized Trial of Sirolimus-Based Graft Versus Host Disease Prophylaxis After Hematopoietic Stem Cell Transplantation in Relapsed Acute Lymphoblastic Leukemia Completed NCT00382109 Phase 3 thiotepa;cyclophosphamide;tacrolimus;methotrexate;sirolimus
6 ALinC 17: Protocol for Patients With Newly Diagnosed High Risk Acute Lymphoblastic Leukemia (ALL) - Evaluation of the Augmented BFM Regimen: A Phase III Study Completed NCT00005603 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
7 ALINC #17 Treatment for Patients With Low Risk Acute Lymphoblastic Leukemia: A Pediatric Oncology Group Phase III Study Completed NCT00005585 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
8 ALL-BFM 2000 Multi-Center Study for the Treatment of Children and Adolescents With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
9 A Multicenter Study of Treatment Protocol for Childhood Acute Lymphoblastic Leukemia in China, 2008. Completed NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
10 Intensive Treatment for Intermediate-Risk Relapse of Childhood B-precursor Acute Lymphoblastic Leukemia (ALL): A Randomized Trial of Vincristine Strategies Completed NCT00381680 Phase 3 vincristine sulfate;prednisone;doxorubicin hydrochloride;pegaspargase;cytarabine;methotrexate;dexamethasone;etoposide;cyclophosphamide;leucovorin calcium;asparaginase;mercaptopurine
11 Standard Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Active, not recruiting NCT00103285 Phase 3 doxorubicin hydrochloride;cytarabine;dexamethasone;pegaspargase;methotrexate;leucovorin calcium;mercaptopurine;cyclophosphamide;thioguanine;vincristine sulfate
12 Multicenter Therapy Study for Children With Mature B-NHL or B-ALL With a Rituximab - Window Before Chemotherapy Completed NCT00324779 Phase 2
13 A Phase I/II Study of Combined Enrichment of CD34+ Cells and Depletion of B-Cells From Peripheral Blood Stem Cell Components for Patients With B-Lymphoid Malignancies Completed NCT00003874 Phase 1, Phase 2
14 Protocol for Patients With Newly Diagnosed Better Risk Acute Lymphoblastic Leukemia (ALL): A POG Pilot Study Completed NCT00003671 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;thioguanine;vincristine sulfate
15 TREATMENT OF ISOLATED CNS RELAPSE OF ACUTE LYMPHOBLASTIC LEUKEMIA -- A PEDIATRIC ONCOLOGY GROUP-WIDE PHASE II STUDY Completed NCT00002704 Phase 2 asparaginase;cyclophosphamide;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;liposomal cytarabine;mercaptopurine;mesna;methotrexate;therapeutic hydrocortisone;thiotepa;vincristine sulfate
16 Phase II Trial of Intensive, Short-Course Combination Chemotherapy in the Treatment of Newly Diagnosed Patients With Poor-Risk Nonlymphoblastic Lymphoma and Acute B-Lymphoblastic Leukemia and in Patients With Recurrent Non-Hodgkin's Lymphoma Completed NCT00002471 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;methotrexate;methylprednisolone;therapeutic hydrocortisone;thiotepa;vincristine sulfate
17 ALinC 17: Continuous Intensification for Very High Risk Acute Lymphocytic Leukemia (A.L.L.): A Pediatric Oncology Group Pilot Study Completed NCT00003783 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;idarubicin;leucovorin calcium;mercaptopurine;methotrexate;prednisone;vincristine sulfate
18 A Phase II Study of Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma Active, not recruiting NCT01700946 Phase 2 dexamethasone;vincristine sulfate;clofarabine;cyclophosphamide;etoposide;pegaspargase;methotrexate;mercaptopurine;cytarabine;mitoxantrone;teniposide;vinblastine;therapeutic hydrocortisone
19 A Phase II Study of Rituximab (IND #7028) and Ifosfamide, Carboplatin and Etoposide (ICE) Chemotherapy in Children With Recurrent/Refractory B-cell (CD20+) Non-Hodgkin Lymphoma and B-cell Acute Lymphoblastic Leukemia Terminated NCT00058461 Phase 2 ifosfamide;etoposide;carboplatin;methotrexate;cytarabine
20 Phase I Study of Adoptive Immunotherapy With CD8 Minor Histocompatibility (H) Antigen-Specific CTL Clones for Patients With Relapsed of AML or ALL After Allogeneic Hematopoietic Stem Cell Transplant Completed NCT00107354 Phase 1 cytarabine;etoposide;mitoxantrone hydrochloride
21 A Pilot Study of Dose Intensification of Methotrexate and Cyclophosphamide in Patients With Advanced-Stage (III/IV) Small Non-Cleaved Non-Hodgkins Lymphoma and B-Cell All- A Limited Institution Phase III Pilot Study Completed NCT00003217 Phase 1 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;methotrexate;vincristine sulfate
22 Phase I Trial and Pharmacokinetic Study of BMS-247550 (NSC 710428, Ixabepilone), an Epothilone B Analog, in Pediatric Patients With Refractory Solid Tumors and Leukemias Completed NCT00030108 Phase 1 ixabepilone
23 A Phase I Study of DT2219ARL, A Bispecific Singe Chain Immunotoxin for the Treatment of Relapsed or Refractory CD19(+), CD22(+) B-Lineage Leukemia or Lymphoma Completed NCT00889408 Phase 1
24 A Phase I Study of Photochemically Treated Donor T-Cell Supplements in HLA Haplotype Mismatched Hematopoietic Stem Cell Transplantation Completed NCT00005092 Phase 1 Cyclophosphamide;Psoralen;Thiotepa
25 Genomic Analysis of Adolescent and Young Adult Acute Lymphoblastic Leukemia Unknown status NCT01653613
26 Multicentric Study for the Treatment of Children With Acute Lymphoblastic Leukemia Unknown status NCT00343369 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;teniposide;thioguanine;vincristine sulfate
27 Feasibility of Minimal Residual Disease (MRD) Determination in Pediatric B-Lineage ALL Using Deep Sequencing of the Immunoglobulin Heavy Chain Locus Completed NCT01629745
28 Identifying Rare Genetic Variants Involved in High Risk Acute Lymphoblastic Leukemia (ALL) Via Pooled DNA Sequencing Completed NCT01119586
29 Molecular Taxonomy of Pediatric Cancer Completed NCT01625143
30 B-precursor Acute Lymphoblastic Leukemia (ALL): Studying the Mechanisms Behind Dexamethasone and Prednisone Sensitivity in High-Risk Patients Completed NCT01553162
31 OBSERVATIONAL: Replication Profiling as a Diagnostic Tool in B-cell Acute Lymphoblastic Leukemia (ALL) Completed NCT01540578
32 Next-Generation Sequencing of Immunoglobulin Heavy Chain Variable Region to Identify Previously Undetectable Minimal Residual Disease in Children With Acute Lymphoblastic Leukemia With Prognostic Significance Completed NCT01533168
33 The Metabolic Syndrome in Pediatric Acute Lymphoblastic Leukemia (ALL). Completed NCT00801346
34 Molecular Correlates of Methotrexate in Childhood ALL Completed NCT00898404
35 Childhood Cancer Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative High-Risk ALL Pilot Project: Application of Array-Based Methods and Gene Re-Sequencing to Identify Candidate Molecular Targets for High-Risk Pediatric Acute Lymphoblastic Leukemia Completed NCT00896766
36 ALinC 17, Classification ©), B-precursor Induction Treatment (I) Completed NCT01225874 SC-PEG E. coli L-asparaginase;cytarabine;daunorubicin hydrochloride;dexamethasone;methotrexate;pegaspargase;prednisone;vincristine sulfate
37 Treatment of Late Isolated Extramedullary Relapse From Acute Lymphoblastic Leukemia (ALL) (Initial CR1≥ 18 Months) Completed NCT00096135 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;therapeutic hydrocortisone;vincristine sulfate
38 Translational Research - Observational Study for Identification of New Possible Prognostic Factors and Future Therapeutic Targets in Children With Acute Lymphoblastic Leukemia (ALL) Active, not recruiting NCT01185886
39 A Phase I Study of Vaccination With Autologous CD40-Activated Acute Lymphoblastic Leukemia Cells Terminated NCT00020670 Early Phase 1

Search NIH Clinical Center for Childhood B-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Childhood B-Cell Acute Lymphoblastic Leukemia

Anatomical Context for Childhood B-Cell Acute Lymphoblastic Leukemia

MalaCards organs/tissues related to Childhood B-Cell Acute Lymphoblastic Leukemia:

40
B Cells, B Lymphoblasts, Liver, T Cells, Testes, Myeloid

Publications for Childhood B-Cell Acute Lymphoblastic Leukemia

Articles related to Childhood B-Cell Acute Lymphoblastic Leukemia:

(show all 46)
# Title Authors PMID Year
1
RUNX1 amplification in lineage conversion of childhood B-cell acute lymphoblastic leukemia to acute myelogenous leukemia. 61 54
17889714 2007
2
Complex karyotype with cryptic FUS gene rearrangement and deletion of NR3C1 and VPREB1 genes in childhood B-cell acute lymphoblastic leukemia: A case report. 61
32218851 2020
3
Identifying IGH disease clones for MRD monitoring in childhood B-cell acute lymphoblastic leukemia using RNA-Seq. 61
32099036 2020
4
Priapism in Childhood B-Cell Acute Lymphoblastic Leukemia: A Rare Presentation. 61
32174697 2020
5
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID. 61
31804490 2019
6
Expression of ZNF695 Transcript Variants in Childhood B-Cell Acute Lymphoblastic Leukemia. 61
31527520 2019
7
Novel ETV6-RUNX1 Mouse Model to Study the Role of ELF-MF in Childhood B-Acute Lymphoblastic Leukemia: a Pilot Study. 61
31157932 2019
8
An investigation of methylation pattern changes in the IKZF1 promoter in patients with childhood B-cell acute lymphoblastic leukemia. 61
31309094 2019
9
Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells. 61
30628662 2019
10
Author Correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. 61
30664635 2019
11
Mir-pharmacogenetics of Vincristine and peripheral neurotoxicity in childhood B-cell acute lymphoblastic leukemia. 61
29282364 2018
12
[Childhood B-cell acute lymphoblastic leukemia of nonL3 morphology with mature phenotype and MLL-AF9 gene fusion: a case report and literatures review]. 61
30486594 2018
13
Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study. 61
30044693 2018
14
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. 61
29632299 2018
15
Is intrachromosomal amplification of chromosome 21 (iAMP21) always intrachromosomal? 61
29153092 2017
16
Upregulation of microRNA-21 is a poor prognostic marker in patients with childhood B cell acute lymphoblastic leukemia. 61
28253825 2017
17
Long-term Results of the Risk-adapted Treatment for Childhood B-Cell Acute Lymphoblastic Leukemia: Report From the Japan Association of Childhood Leukemia Study ALL-97 Trial. 61
28169879 2017
18
Prognostic significance of P2RY8-CRLF2 and CRLF2 overexpression may vary across risk subgroups of childhood B-cell acute lymphoblastic leukemia. 61
27637012 2017
19
Specific expression of novel long non-coding RNAs in high-hyperdiploid childhood acute lymphoblastic leukemia. 61
28346506 2017
20
Family-based exome-wide assessment of maternal genetic effects on susceptibility to childhood B-cell acute lymphoblastic leukemia in hispanics. 61
27529658 2016
21
MiR-pharmacogenetics of methotrexate in childhood B-cell acute lymphoblastic leukemia. 61
27649261 2016
22
[Application of Combined Detection of Fusion Gene and BIOMED-2 Standardized Ig Gene Rearrangement System in Childhood B-cell Acute Lymphoblastic Leukemia]. 61
27150991 2016
23
[Clinical value of minimal residual disease detection by flow cytometry in childhood B-cell acute lymphoblastic leukemia]. 61
25523574 2014
24
Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL. 61
25298122 2014
25
Repetitive genomic elements and overall DNA methylation changes in acute myeloid and childhood B-cell lymphoblastic leukemia patients. 61
24841671 2014
26
Chimeric fusion karyotypes in childhood B-cell acute lymphoblastic leukemia. 61
24632701 2014
27
An unusual case of high hyperdiploid childhood ALL with cryptic BCR/ABL1 rearrangement. 61
25360156 2014
28
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. 61
23996088 2013
29
Aberrations of chromosomes 9 and 22 in acute lymphoblastic leukemia cases detected by ES-fluorescence in situ hybridization. 61
22360868 2012
30
Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell acute lymphoblastic leukemia. 61
21813177 2012
31
[Clinical significance of sequential monitoring minimal residual disease in childhood B-cell acute lymphoblastic leukemia]. 61
21781499 2011
32
DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia. 61
22122053 2010
33
Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia. 61
20460642 2010
34
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood. 61
20042726 2010
35
[Clinical importance of minimal residual disease testing in the therapy of childhood B-cell acute lymphoblastic leukemia]. 61
18554462 2008
36
[Prognostic value of minimal residual disease in childhood B-cell acute lymphoblastic leukemia]. 61
16732969 2006
37
The t(12:21) is underrepresented in childhood B-lineage acute lymphoblastic leukemia in Kerala, Southern India. 61
15749681 2005
38
[Real-time quantitative study of minimal residual disease in childhood B cell acute lymphoblastic leukemia]. 61
15347448 2004
39
[Characteristics of immunoglobulin heavy chain variable region genes in childhood B-cell acute lymphoblastic leukemia]. 61
14990068 2004
40
Recent thymic emigrants and prognosis in T- and B-cell childhood hematopoietic malignancies. 61
12209591 2002
41
Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia. 61
11867721 2002
42
Functional characterization of TEL/AML1 fusion protein in the regulation of human CR1 gene promoter. 61
10597047 1999
43
Childhood B-cell acute lymphoblastic leukemia with FAB-L1 morphology and a t(9;11) translocation involving the MLL gene. 61
8974790 1996
44
Indirect and direct disruption of transcriptional regulation in cancer: E2F and AML-1. 54
8834231 1995
45
Cytogenetic features of Hodgkin's disease suggest possible origin from a lymphocyte. 61
3370310 1988
46
Idiotype as a tumor-specific marker in childhood B cell acute lymphoblastic leukemia. 61
3128346 1988

Variations for Childhood B-Cell Acute Lymphoblastic Leukemia

Expression for Childhood B-Cell Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for Childhood B-Cell Acute Lymphoblastic Leukemia.

Pathways for Childhood B-Cell Acute Lymphoblastic Leukemia

Pathways related to Childhood B-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 RUNX1 PAX5 IKZF1
2 11.42 RUNX1 PAX5 CEBPE
3 10.84 RUNX1 IKZF1
4 10.7 RUNX1 IKZF1 CRLF2

GO Terms for Childhood B-Cell Acute Lymphoblastic Leukemia

Biological processes related to Childhood B-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.35 RUNX1 PAX5 IKZF1 CEBPE CDKN2A
2 regulation of B cell receptor signaling pathway GO:0050855 8.62 RUNX1 PAX5

Molecular functions related to Childhood B-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.63 RUNX1 PAX5 IKZF1 CEBPE CDKN2A ARID5B
2 transcription regulatory region sequence-specific DNA binding GO:0000976 9.43 RUNX1 IKZF1 ARID5B
3 transcription regulatory region DNA binding GO:0044212 9.13 RUNX1 IKZF1 ARID5B
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.92 RUNX1 PAX5 IKZF1 CEBPE

Sources for Childhood B-Cell Acute Lymphoblastic Leukemia

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