MCID: CHL057
MIFTS: 19

Childhood Brain Stem Glioma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Childhood Brain Stem Glioma

MalaCards integrated aliases for Childhood Brain Stem Glioma:

Name: Childhood Brain Stem Glioma 12 53 15
Pediatric Glioma of the Brainstem 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6383
NCIt 50 C9042
UMLS 72 C0278600

Summaries for Childhood Brain Stem Glioma

NIH Rare Diseases : 53 Childhood brain stem glioma is a rare condition in which abnormal cells develop in the tissues of the brain stem (the part of the brain connected to the spinal cord). The condition can be benign (noncancerous) or malignant (cancerous). The severity of the condition and the associated signs and symptoms vary based on the size and location of the tumor and how quickly the tumor is growing. Common features include difficulty walking; loss of the ability to move one side of the body or face; vision or hearing problems; headaches (particularly in the morning); nausea and vomiting; unusual sleepiness; and behavioral changes. In most cases, the underlying cause of childhood brain stem glioma is unknown. Certain genetic conditions, such as neurofibromatosis type I, are associated with an increased risk of childhood brainstem glioma. Treatment varies but may include surgery, radiation therapy, chemotherapy, cerebrospinal fluid diversion, observation, and targeted therapy.

MalaCards based summary : Childhood Brain Stem Glioma, also known as pediatric glioma of the brainstem, is related to brain stem glioma and hydrocephalus. An important gene associated with Childhood Brain Stem Glioma is SNORD13 (Small Nucleolar RNA, C/D Box 13). The drugs Levoleucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and liver.

Related Diseases for Childhood Brain Stem Glioma

Diseases related to Childhood Brain Stem Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 brain stem glioma 10.1
2 hydrocephalus 9.9
3 congenital hydrocephalus 9.9
4 glioma 9.9
5 seizure disorder 9.9
6 glial tumor 9.9

Graphical network of the top 20 diseases related to Childhood Brain Stem Glioma:



Diseases related to Childhood Brain Stem Glioma

Symptoms & Phenotypes for Childhood Brain Stem Glioma

Drugs & Therapeutics for Childhood Brain Stem Glioma

Drugs for Childhood Brain Stem Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 183)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
2
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
3
leucovorin Approved Phase 3 58-05-9 143 6006
4
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
5
Procarbazine Approved, Investigational Phase 3 671-16-9 4915
6
Lomustine Approved, Investigational Phase 3 13010-47-4 3950
7
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
8
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
10
Thioguanine Approved Phase 3 154-42-7 2723601
11
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
12
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
13
Ondansetron Approved Phase 3 99614-02-5 4595
14
Histamine Approved, Investigational Phase 3 51-45-6 774
15
Cyproheptadine Approved Phase 3 129-03-3 2913
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
17
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
18 Folic Acid Antagonists Phase 3
19 Folate Phase 3
20 Vitamin B9 Phase 3
21 Vitamin B Complex Phase 3
22 Nucleic Acid Synthesis Inhibitors Phase 3
23 Calcium, Dietary Phase 3
24 Antirheumatic Agents Phase 3
25 Anti-Inflammatory Agents Phase 3
26 Hormones Phase 3
27 Hormone Antagonists Phase 3
28 Antineoplastic Agents, Hormonal Phase 3
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
30 glucocorticoids Phase 3
31 Antimetabolites Phase 3
32 Antimetabolites, Antineoplastic Phase 3
33 Tubulin Modulators Phase 3
34 Antimitotic Agents Phase 3
35 Peripheral Nervous System Agents Phase 3
36 BB 1101 Phase 3
37 Antiemetics Phase 3
38 Autonomic Agents Phase 3
39 Emetics Phase 3
40 Dermatologic Agents Phase 3
41 Neurotransmitter Agents Phase 3
42 Gastrointestinal Agents Phase 3
43 Anti-Allergic Agents Phase 3
44 Serotonin Antagonists Phase 3
45 Histamine H1 Antagonists Phase 3
46 Histamine Antagonists Phase 3
47 Serotonin Agents Phase 3
48
Histamine Phosphate Phase 3 51-74-1 65513
49 Antipruritics Phase 3
50
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Treatment of Children and Adolescents With Diffuse Intrinsic Pontine Glioma and High Grade Glioma Unknown status NCT00278278 Phase 3 cisplatin;etoposide;ifosfamide;lomustine;methotrexate;prednisone;vincristine sulfate
2 Chemotherapy for Progressive Low Grade Astrocytoma in Children Less Than Ten Years Old Completed NCT00002944 Phase 3 carboplatin;lomustine;procarbazine hydrochloride;thioguanine;vincristine sulfate
3 Randomized Controlled Trial of Acupressure to Control Chemotherapy-Induced Nausea (CIN) in Children Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
4 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 A Phase II Multi-Centre Study of Concomitant and Prolonged Adjuvant Temozolomide With Radiotherapy in Diffuse Pontine Gliomas Unknown status NCT00514397 Phase 2 motexafin gadolinium;temozolomide
6 Management of Children Aged Less Than 3 Years With Brain Tumors Unknown status NCT00281905 Phase 2 carboplatin;cisplatin;cyclophosphamide;methotrexate;vincristine sulfate
7 Phase II Treatment of Adults and Children With Progressive Low Grade Gliomas With Temodal Completed NCT00003466 Phase 2 temozolomide
8 PHASE II STUDY OF CARBOPLATIN (CBDCA) IN THE TREATMENT OF CHILDREN AND ADULTS WITH PROGRESSIVE LOW GRADE GLIOMAS Completed NCT00002749 Phase 2 carboplatin
9 Phase II Study of Antineoplastons A10 and AS2-1 In Patients With Brain Stem Glioma Completed NCT00003459 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
10 Phase II Study of Phenylacetate in Pediatric Patients With Central Nervous System Tumors Completed NCT00003241 Phase 2 phenylacetate
11 A PHASE II STUDY OF DOCETAXEL (TAXOTERE) (NSC# 628503) IN CHILDREN WITH RECURRENT SOLID TUMORS Completed NCT00002825 Phase 2 docetaxel
12 A Phase II Study of Motexafin-Gadolinium (NSC 695238, IND #55583) and Involved Field Radiation Therapy for Intrinsic Pontine Glioma of Childhood Completed NCT00387790 Phase 2 motexafin gadolinium
13 A Phase I/II Trial of Temodar in Pediatric Patients and Young Adults With High-Risk or Recurrent Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
14 A Phase II Trial of O6-Benzylguanine and Temozolomide in Pediatric Patients With Recurrent or Progressive High-Grade Gliomas and Recurrent or Progressive Brainstem Tumors Completed NCT00275002 Phase 2 O6-benzylguanine;temozolomide
15 A Phase II Trial of Rebeccamycin Analogue (NSC #655649) in Children With Solid Tumors Completed NCT00006102 Phase 2 becatecarin
16 Treatment of Newly Diagnosed High-Grade Gliomas in Patients Ages Greater Than or Equal to 3 and Less Than or Equal to 21 Years With a Phase II Irinotecan Window Followed by Radiation Therapy and Temozolomide Completed NCT00004068 Phase 2 irinotecan hydrochloride;temozolomide
17 A TRIAL OF INTENSIVE CHEMOTHERAPY AND AUTOLOGOUS STEM CELL RECONSTITUTION FOR PATIENTS BETWEEN SIX AND SIXTY YEARS OF AGE, WITH NON-PROGRESSIVE GLIOBLASTOMA MULTIFORME OR DIFFUSE INTRINSIC BRAINSTEM TUMORS, FOLLOWING INITIAL LOCAL-FIELD IRRADIATION Completed NCT00002619 Phase 2 carboplatin;thiotepa
18 Cisplatin, Doxorubicin and Tamoxifen in the Treatment of Incurable Soft Tissue and Endocrine Malignancies Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
19 The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment Related Cachexia Completed NCT00066248 Phase 2 cyproheptadine hydrochloride;megestrol acetate
20 Phase II Trial Of High Dose Cyclophosphamide, Cisplatin And Carmustine With Stem Cell Reconstitution Followed By Specific Cellular Therapy In Patients With Recurrent Or Refractory Brain Tumors Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
21 Phase I/II Trial of R115777 and XRT in Pediatric Patients With Newly Diagnosed Non-Disseminated Intrinsic Diffuse Brainstem Gliomas Completed NCT00079339 Phase 1, Phase 2 tipifarnib
22 Phase II, Single Arm, Open Label Clinical Trial With Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas Completed NCT01574092 Phase 2 Combination of two marketed drugs (irinotecan and cisplatin)
23 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
24 Dasatinib With Ifosfamide, Carboplatin, Etoposide: A Pediatric Phase I/II Trial Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
25 A Phase I/II Study of Topotecan With G-CSF and Radiation Therapy in Children With Malignant Intrinsic Pontine Brainstem Gliomas of Childhood Terminated NCT00107471 Phase 1, Phase 2 topotecan hydrochloride
26 Phase I Studies of TARCEVA™ (ERLOTINIB HYDROCHLORIDE, OSI-774) as Single Agent in Children With Refractory and Relapsed Malignant Brain Tumors and in Combination With Irradiation in Newly Diagnosed Brain Stem Glioma Unknown status NCT00360854 Phase 1 erlotinib hydrochloride
27 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
28 Study to Determine the Maximum Tolerated Time of Infusion for High-Dose Methotrexate, Administered as a Continuous Intravenous Infusion at a Dose of 6g/m² Per 24 Hours of Infusion Time Completed NCT00513981 Phase 1 leucovorin calcium;methotrexate
29 Phase I Trial of Vandetanib (ZD6474, ZACTIMA) With Concurrent Radiation in Treatment of Newly Diagnosed Brainstem Glioma Completed NCT00472017 Phase 1 vandetanib
30 Phase I Study of Doxorubicin HCl Liposome in Pediatric Patients With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
31 A Pilot Study of Dose-Intensified Procarbazine, CCNU, Vincristine (PCV) for Poor Prognosis Pediatric and Adult Brain Tumors Utilizing Fibronectin-Assisted, Retroviral-Mediated Modification of CD34+ Peripheral Blood Cells With O6-Methylguanine DNA Methyltransferase Completed NCT00005796 Phase 1 lomustine;procarbazine hydrochloride;vincristine sulfate
32 A Phase I Dose Escalation Study of Intravenous DX-8951f Administered Daily for Five Days Every Three Weeks to Pediatric Patients With Advanced Solid Tumors and Lymphomas Completed NCT00004212 Phase 1 exatecan mesylate
33 A PHASE I STUDY OF FLAVOPIRIDOL (NSC# 649890; IND# 46211) IN PATIENTS WITH RELAPSED OR REFRACTORY PEDIATRIC SOLID TUMORS OR LYMPHOMAS Completed NCT00012181 Phase 1 alvocidib
34 A Phase I Trial of Arsenic Trioxide in the Treatment of Infiltrating Gliomas of Childhood Completed NCT00095771 Phase 1 arsenic trioxide
35 Phase I Study of Concurrent Cereport and Carboplatin With Radiation Therapy for Children With Newly-Diagnosed Brain Stem Gliomas Completed NCT00005602 Phase 1 carboplatin;cereport
36 Treatment of Children With Diffuse Intrinsic Brain Stem Glioma With Standard Dose Irradiation and Vincristine Plus Oral VP-16, A POG Pilot Study Completed NCT00003935 Phase 1 etoposide;vincristine sulfate
37 A Phase I Study of Motexafin Gadolinium (Xcytrin, NSC 695238) and Involved Field Radiation Therapy for Intrinsic Pontine Glioma of Childhood Completed NCT00003909 Phase 1 motexafin gadolinium
38 Phase I and Pharmacokinetic Trial of PTC299 in Pediatric Patients With Refractory or Recurrent CNS Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
39 Phase I Study of Intrathecal Spartaject-Busulfan in Children With Neoplastic Meningitis Completed NCT00006246 Phase 1 busulfan
40 Phase I Study Of Cloretazine (VNP40101M) In Children With Recurrent, Progressive Or Refractory Primary Brain Tumors Completed NCT00098761 Phase 1 laromustine
41 A Trial of 06-BG and BCNU in Children With CNS Tumors Completed NCT00003765 Phase 1 O6-benzylguanine;carmustine
42 Vincristine, Etoposide and Cyclosporine A in Concert With Standard Dose Radiation Therapy in Diffuse Intrinsic Brain Stem Glioma - A Phase I Study of Dose Escalation of Vincristine Completed NCT00003625 Phase 1 cyclosporine;etoposide;vincristine sulfate
43 High Dose Carboplatin Combined With Oral VP-16 In The Treatment Of Pediatric CNS Malignancies Completed NCT00053118 Phase 1 carboplatin;etoposide
44 Phase I Study of Intrathecal 131-I-3F8 Monoclonal Antibody in Patients With GD2 Positive Leptomeningeal Neoplasms Completed NCT00003022 Phase 1
45 A Phase I Trial and Pharmacokinetic Study of Talabostat (PT-100, Val-Boro-Pro) in Combination With Temozolomide or Carboplatin in Pediatric Patients With Relapsed or Refractory Solid Tumors Including Brain Tumors Completed NCT00303940 Phase 1 carboplatin;talabostat mesylate;temozolomide
46 A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children With Refractory or Recurrent Solid Tumors and Lymphomas Completed NCT01273090 Phase 1 imetelstat sodium
47 A Phase I Trial of Capecitabine Rapidly Disintegrating Tablets and Concomitant Radiation Therapy in Children With Newly Diagnosed Brainstem Gliomas and High Grade Gliomas Completed NCT00357253 Phase 1 capecitabine
48 A Phase I Study of Valproic Acid in Children With Recurrent/Progressive Solid Tumors Including CNS Tumors Completed NCT00107458 Phase 1 valproic acid
49 A Phase I Study of Thrombopoietin (rhTPO) Plus G-CSF in Children Receiving Ifosfamide, Carboplatin, and Etoposide (I.C.E.) Chemotherapy for Recurrent or Refractory Solid Tumors Completed NCT00003597 Phase 1 carboplatin;etoposide;ifosfamide
50 A Pilot Study of Intensive Chemotherapy With Peripheral Stem Cell Support for Infants With Malignant Brain Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate

Search NIH Clinical Center for Childhood Brain Stem Glioma

Genetic Tests for Childhood Brain Stem Glioma

Anatomical Context for Childhood Brain Stem Glioma

MalaCards organs/tissues related to Childhood Brain Stem Glioma:

41
Brain, Spinal Cord, Liver, Bone

Publications for Childhood Brain Stem Glioma

Variations for Childhood Brain Stem Glioma

Expression for Childhood Brain Stem Glioma

Search GEO for disease gene expression data for Childhood Brain Stem Glioma.

Pathways for Childhood Brain Stem Glioma

GO Terms for Childhood Brain Stem Glioma

Sources for Childhood Brain Stem Glioma

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