MCID: CHL057
MIFTS: 32

Childhood Brain Stem Glioma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Childhood Brain Stem Glioma

MalaCards integrated aliases for Childhood Brain Stem Glioma:

Name: Childhood Brain Stem Glioma 12 52 15
Pediatric Glioma of the Brainstem 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6383
NCIt 49 C9042
UMLS 71 C0278600

Summaries for Childhood Brain Stem Glioma

NIH Rare Diseases : 52 Childhood brain stem glioma is a rare condition in which abnormal cells develop in the tissues of the brain stem (the part of the brain connected to the spinal cord). The condition can be benign (noncancerous) or malignant (cancerous). The severity of the condition and the associated signs and symptoms vary based on the size and location of the tumor and how quickly the tumor is growing. Common features include difficulty walking; loss of the ability to move one side of the body or face; vision or hearing problems; headaches (particularly in the morning); nausea and vomiting; unusual sleepiness; and behavioral changes. In most cases, the underlying cause of childhood brain stem glioma is unknown. Certain genetic conditions, such as neurofibromatosis type I , are associated with an increased risk of childhood brainstem glioma. Treatment varies but may include surgery, radiation therapy , chemotherapy , cerebrospinal fluid diversion , observation, and targeted therapy .

MalaCards based summary : Childhood Brain Stem Glioma, also known as pediatric glioma of the brainstem, is related to glial tumor and glioma. An important gene associated with Childhood Brain Stem Glioma is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Levoleucovorin and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and liver.

Related Diseases for Childhood Brain Stem Glioma

Diseases related to Childhood Brain Stem Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 glial tumor 30.3 OLIG2 IDH1
2 glioma 29.8 PDGFRA IDH1 H3C11 H3C1 H3-3A
3 brain stem glioma 26.3 PDGFRA OLIG2 IDH1 H3C8 H3C7 H3C6
4 bone giant cell sarcoma 10.4 H3-3B H3-3A
5 malignant giant cell tumor 10.4 H3-3B H3-3A
6 kunjin encephalitis 10.3 H3-3B H3-3A
7 pneumoconiosis due to talc 10.3 H3-3B H3-3A
8 actinomycosis 10.3 H3-3B H3-3A H2AC18
9 mulibrey nanism 10.3 H3-3B H3-3A H2AC18
10 benign giant cell tumor 10.3 H3-3B H3-3A H2AC18
11 mental retardation, autosomal dominant 56 10.3 H3-3B H3-3A
12 pilocytic astrocytoma of cerebellum 10.3 IDH1 H3C11 H3C10
13 hypotrichosis 1 10.3 H3-3B H3-3A H2AC18
14 pelizaeus-merzbacher disease 10.3 H3-3B H3-3A H2AC18
15 high-grade astrocytoma 10.2 IDH1 ACVR1
16 congenital disorder of glycosylation, type il 10.2 H3-3B H3-3A
17 adult brain stem glioma 10.2 IDH1 H3-3B H3-3A
18 alpha thalassemia-x-linked intellectual disability syndrome 10.2 H3-2 H2AC18 ATRX
19 temporal lobe neoplasm 10.2 IDH1 ATRX
20 amelogenesis imperfecta, type if 10.2 H3-3B H3-3A
21 spinal cord astrocytoma 10.2 IDH1 H3-3B H3-3A
22 spinal cord oligodendroglioma 10.2 IDH1 ATRX
23 immunodeficiency-centromeric instability-facial anomalies syndrome 10.2 H3-2 H2AC18 ATRX
24 retinitis pigmentosa 18 10.2 H3C8 H3C4 H2AC18 ATRX
25 adult oligodendroglioma 10.2 OLIG2 IDH1
26 cerebellar astrocytoma 10.2 IDH1 H3C12 H3C11 H3C10
27 otopalatodigital syndrome, type i 10.2 H3-2 H2AC18
28 mixed oligodendroglioma-astrocytoma 10.1 IDH1 ATRX
29 hypotrichosis 2 10.1 H3-3B H3-3A H3-2 H2AC18
30 pleomorphic xanthoastrocytoma 10.1 IDH1 H3-3A ATRX
31 carbohydrate metabolic disorder 10.1 H3-2 H2AC18 EZH2
32 chondroblastoma 10.1 H3C6 H3C3 H3-3B H3-3A H2AC18
33 adult astrocytic tumour 10.1 PDGFRA IDH1 ATRX
34 clear cell ependymoma 10.1 OLIG2 IDH1
35 tonsil squamous cell carcinoma 10.1 H3C7 H3C12 H3C11 H3C10 H3C1
36 childhood oligodendroglioma 10.0 OLIG2 IDH1 ATRX
37 amelogenesis imperfecta, type ia 10.0 H3-3B H3-3A
38 cerebrum cancer 10.0 OLIG2 IDH1 ATRX
39 cerebral ventricle cancer 10.0 OLIG2 IDH1 ATRX
40 supratentorial primitive neuroectodermal tumor 10.0 OLIG2 IDH1
41 brain glioma 10.0 IDH1 EZH2 ATRX
42 sotos syndrome 1 10.0 H3-2 H2AC18 EZH2 ATRX
43 adult infiltrating astrocytic neoplasm 10.0 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
44 hyperoxaluria, primary, type i 10.0 H3-2 H2AC18 EZH2 ATRX
45 weaver syndrome 10.0 H3-2 H2AC18 EZH2 ATRX
46 primary hyperoxaluria 10.0 H3-2 H2AC18 EZH2 ATRX
47 central nervous system benign neoplasm 9.9 OLIG2 IDH1 H2AC18 ATRX
48 hydrocephalus 9.9
49 seizure disorder 9.9
50 suppression of tumorigenicity 12 9.9 IDH1 H3-2 H2AC18 EZH2

Graphical network of the top 20 diseases related to Childhood Brain Stem Glioma:



Diseases related to Childhood Brain Stem Glioma

Symptoms & Phenotypes for Childhood Brain Stem Glioma

Drugs & Therapeutics for Childhood Brain Stem Glioma

Drugs for Childhood Brain Stem Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 158)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
2
leucovorin Approved Phase 3 58-05-9 6006 143
3
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
4
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
5
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
6
Procarbazine Approved, Investigational Phase 3 671-16-9 4915
7
Lomustine Approved, Investigational Phase 3 13010-47-4 3950
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
10
Thioguanine Approved Phase 3 154-42-7 2723601
11
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
12
Ondansetron Approved Phase 3 99614-02-5 4595
13
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
14
Histamine Approved, Investigational Phase 3 51-45-6 774
15
Cyproheptadine Approved Phase 3 129-03-3 2913
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
17 Vitamin B Complex Phase 3
18 Hormones Phase 3
19 Folic Acid Antagonists Phase 3
20 Folate Phase 3
21 Calcium, Dietary Phase 3
22 Antirheumatic Agents Phase 3
23 Vitamin B9 Phase 3
24 Hormone Antagonists Phase 3
25 Antineoplastic Agents, Hormonal Phase 3
26 Anti-Inflammatory Agents Phase 3
27 glucocorticoids Phase 3
28 Antimetabolites Phase 3
29 Tubulin Modulators Phase 3
30 Antimitotic Agents Phase 3
31 Antiemetics Phase 3
32 Emetics Phase 3
33 Dermatologic Agents Phase 3
34 Neurotransmitter Agents Phase 3
35 Histamine Antagonists Phase 3
36 Anti-Allergic Agents Phase 3
37
Histamine Phosphate Phase 3 51-74-1 65513
38 Histamine H1 Antagonists Phase 3
39 Gastrointestinal Agents Phase 3
40
Calcium Nutraceutical Phase 3 7440-70-2 271
41
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
42
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
43
Phenylacetic acid Approved Phase 2 103-82-2 999
44
Sodium citrate Approved, Investigational Phase 2 68-04-2
45
Tamoxifen Approved Phase 2 10540-29-1 2733526
46
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
47
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
48
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
49
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
50
Carmustine Approved, Investigational Phase 2 154-93-8 2578

Interventional clinical trials:

(show top 50) (show all 72)
# Name Status NCT ID Phase Drugs
1 Treatment of Children and Adolescents With Diffuse Intrinsic Pontine Glioma and High Grade Glioma Unknown status NCT00278278 Phase 3 cisplatin;etoposide;ifosfamide;lomustine;methotrexate;prednisone;vincristine sulfate
2 Chemotherapy for Progressive Low Grade Astrocytoma in Children Less Than Ten Years Old Completed NCT00002944 Phase 3 carboplatin;lomustine;procarbazine hydrochloride;thioguanine;vincristine sulfate
3 Randomized Controlled Trial of Acupressure to Control Chemotherapy-Induced Nausea (CIN) in Children Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
4 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Treatment of Children With Newly Diagnosed Diffuse Pontine Gliomas Using Conventional Radiotherapy and High Dose Tamoxifen Unknown status NCT00024336 Phase 2 tamoxifen citrate
6 A Phase II Multi-Centre Study of Concomitant and Prolonged Adjuvant Temozolomide With Radiotherapy in Diffuse Pontine Gliomas Unknown status NCT00514397 Phase 2 motexafin gadolinium;temozolomide
7 Management of Children Aged Less Than 3 Years With Brain Tumors Unknown status NCT00281905 Phase 2 carboplatin;cisplatin;cyclophosphamide;methotrexate;vincristine sulfate
8 Phase II Treatment of Adults and Children With Progressive Low Grade Gliomas With Temodal Completed NCT00003466 Phase 2 temozolomide
9 PHASE II STUDY OF CARBOPLATIN (CBDCA) IN THE TREATMENT OF CHILDREN AND ADULTS WITH PROGRESSIVE LOW GRADE GLIOMAS Completed NCT00002749 Phase 2 carboplatin
10 Phase II Study of Antineoplastons A10 and AS2-1 In Patients With Brain Stem Glioma Completed NCT00003459 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
11 Phase II Study of Phenylacetate in Pediatric Patients With Central Nervous System Tumors Completed NCT00003241 Phase 2 phenylacetate
12 A Phase II Study of Temozolomide in the Treatment of Children With High Grade Glioma Completed NCT00028795 Phase 2 temozolomide
13 A Phase II Study of Motexafin-Gadolinium (NSC 695238, IND #55583) and Involved Field Radiation Therapy for Intrinsic Pontine Glioma of Childhood Completed NCT00387790 Phase 2 motexafin gadolinium
14 A PHASE II STUDY OF DOCETAXEL (TAXOTERE) (NSC# 628503) IN CHILDREN WITH RECURRENT SOLID TUMORS Completed NCT00002825 Phase 2 docetaxel
15 A Phase I/II Trial of Temodar in Pediatric Patients and Young Adults With High-Risk or Recurrent Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
16 A Phase II Trial of Rebeccamycin Analogue (NSC #655649) in Children With Solid Tumors Completed NCT00006102 Phase 2 becatecarin
17 Treatment of Newly Diagnosed High-Grade Gliomas in Patients Ages Greater Than or Equal to 3 and Less Than or Equal to 21 Years With a Phase II Irinotecan Window Followed by Radiation Therapy and Temozolomide Completed NCT00004068 Phase 2 irinotecan hydrochloride;temozolomide
18 A TRIAL OF INTENSIVE CHEMOTHERAPY AND AUTOLOGOUS STEM CELL RECONSTITUTION FOR PATIENTS BETWEEN SIX AND SIXTY YEARS OF AGE, WITH NON-PROGRESSIVE GLIOBLASTOMA MULTIFORME OR DIFFUSE INTRINSIC BRAINSTEM TUMORS, FOLLOWING INITIAL LOCAL-FIELD IRRADIATION Completed NCT00002619 Phase 2 carboplatin;thiotepa
19 Cisplatin, Doxorubicin and Tamoxifen in the Treatment of Incurable Soft Tissue and Endocrine Malignancies Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
20 A Phase II Trial of O6-Benzylguanine and Temozolomide in Pediatric Patients With Recurrent or Progressive High-Grade Gliomas and Recurrent or Progressive Brainstem Tumors Completed NCT00275002 Phase 2 O6-benzylguanine;temozolomide
21 The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment Related Cachexia Completed NCT00066248 Phase 2 cyproheptadine hydrochloride;megestrol acetate
22 Phase I/II Trial of R115777 and XRT in Pediatric Patients With Newly Diagnosed Non-Disseminated Intrinsic Diffuse Brainstem Gliomas Completed NCT00079339 Phase 1, Phase 2 tipifarnib
23 Phase II Trial Of High Dose Cyclophosphamide, Cisplatin And Carmustine With Stem Cell Reconstitution Followed By Specific Cellular Therapy In Patients With Recurrent Or Refractory Brain Tumors Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
24 Phase II, Single Arm, Open Label Clinical Trial With Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas Completed NCT01574092 Phase 2 Combination of two marketed drugs (irinotecan and cisplatin)
25 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
26 Dasatinib With Ifosfamide, Carboplatin, Etoposide: A Pediatric Phase I/II Trial Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
27 A Phase I/II Trial Of STI571 In Children With Newly Diagnosed Poor Prognosis Brainstem Gliomas And Recurrent Intracranial Malignant Gliomas Terminated NCT00021229 Phase 1, Phase 2 imatinib mesylate
28 A Phase I/II Study of Topotecan With G-CSF and Radiation Therapy in Children With Malignant Intrinsic Pontine Brainstem Gliomas of Childhood Terminated NCT00107471 Phase 1, Phase 2 topotecan hydrochloride
29 Phase I Studies of TARCEVA™ (ERLOTINIB HYDROCHLORIDE, OSI-774) as Single Agent in Children With Refractory and Relapsed Malignant Brain Tumors and in Combination With Irradiation in Newly Diagnosed Brain Stem Glioma Unknown status NCT00360854 Phase 1 erlotinib hydrochloride
30 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
31 Study to Determine the Maximum Tolerated Time of Infusion for High-Dose Methotrexate, Administered as a Continuous Intravenous Infusion at a Dose of 6g/m² Per 24 Hours of Infusion Time Completed NCT00513981 Phase 1 leucovorin calcium;methotrexate
32 A PHASE I STUDY OF FLAVOPIRIDOL (NSC# 649890; IND# 46211) IN PATIENTS WITH RELAPSED OR REFRACTORY PEDIATRIC SOLID TUMORS OR LYMPHOMAS Completed NCT00012181 Phase 1 alvocidib
33 Phase I Trial of Vandetanib (ZD6474, ZACTIMA) With Concurrent Radiation in Treatment of Newly Diagnosed Brainstem Glioma Completed NCT00472017 Phase 1 vandetanib
34 A Pilot Study of Dose-Intensified Procarbazine, CCNU, Vincristine (PCV) for Poor Prognosis Pediatric and Adult Brain Tumors Utilizing Fibronectin-Assisted, Retroviral-Mediated Modification of CD34+ Peripheral Blood Cells With O6-Methylguanine DNA Methyltransferase Completed NCT00005796 Phase 1 lomustine;procarbazine hydrochloride;vincristine sulfate
35 A Phase I Dose Escalation Study of Intravenous DX-8951f Administered Daily for Five Days Every Three Weeks to Pediatric Patients With Advanced Solid Tumors and Lymphomas Completed NCT00004212 Phase 1 exatecan mesylate
36 Phase I Study of Doxorubicin HCl Liposome in Pediatric Patients With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
37 A Phase I Trial of Arsenic Trioxide in the Treatment of Infiltrating Gliomas of Childhood Completed NCT00095771 Phase 1 arsenic trioxide
38 Phase I Study of Concurrent Cereport and Carboplatin With Radiation Therapy for Children With Newly-Diagnosed Brain Stem Gliomas Completed NCT00005602 Phase 1 carboplatin;cereport
39 Treatment of Children With Diffuse Intrinsic Brain Stem Glioma With Standard Dose Irradiation and Vincristine Plus Oral VP-16, A POG Pilot Study Completed NCT00003935 Phase 1 etoposide;vincristine sulfate
40 A Phase I Study of Motexafin Gadolinium (Xcytrin, NSC 695238) and Involved Field Radiation Therapy for Intrinsic Pontine Glioma of Childhood Completed NCT00003909 Phase 1 motexafin gadolinium
41 Phase I and Pharmacokinetic Trial of PTC299 in Pediatric Patients With Refractory or Recurrent CNS Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
42 Phase I Study Of Cloretazine (VNP40101M) In Children With Recurrent, Progressive Or Refractory Primary Brain Tumors Completed NCT00098761 Phase 1 laromustine
43 Phase I Study of Intrathecal Spartaject-Busulfan in Children With Neoplastic Meningitis Completed NCT00006246 Phase 1 busulfan
44 A Trial of 06-BG and BCNU in Children With CNS Tumors Completed NCT00003765 Phase 1 O6-benzylguanine;carmustine
45 Vincristine, Etoposide and Cyclosporine A in Concert With Standard Dose Radiation Therapy in Diffuse Intrinsic Brain Stem Glioma - A Phase I Study of Dose Escalation of Vincristine Completed NCT00003625 Phase 1 cyclosporine;etoposide;vincristine sulfate
46 Phase I Study of Intrathecal 131-I-3F8 Monoclonal Antibody in Patients With GD2 Positive Leptomeningeal Neoplasms Completed NCT00003022 Phase 1
47 High Dose Carboplatin Combined With Oral VP-16 In The Treatment Of Pediatric CNS Malignancies Completed NCT00053118 Phase 1 carboplatin;etoposide
48 A Phase I Trial of Capecitabine Rapidly Disintegrating Tablets and Concomitant Radiation Therapy in Children With Newly Diagnosed Brainstem Gliomas and High Grade Gliomas Completed NCT00357253 Phase 1 capecitabine
49 A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children With Refractory or Recurrent Solid Tumors and Lymphomas Completed NCT01273090 Phase 1 imetelstat sodium
50 A Phase I Study of Valproic Acid in Children With Recurrent/Progressive Solid Tumors Including CNS Tumors Completed NCT00107458 Phase 1 valproic acid

Search NIH Clinical Center for Childhood Brain Stem Glioma

Genetic Tests for Childhood Brain Stem Glioma

Anatomical Context for Childhood Brain Stem Glioma

MalaCards organs/tissues related to Childhood Brain Stem Glioma:

40
Brain, Spinal Cord, Liver

Publications for Childhood Brain Stem Glioma

Variations for Childhood Brain Stem Glioma

Expression for Childhood Brain Stem Glioma

Search GEO for disease gene expression data for Childhood Brain Stem Glioma.

Pathways for Childhood Brain Stem Glioma

Pathways related to Childhood Brain Stem Glioma according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.17 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
2
Show member pathways
14 PDGFRA IDH1 H3C8 H3C7 H3C6 H3C4
3
Show member pathways
13.91 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
4
Show member pathways
13.91 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
5
Show member pathways
13.88 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
6
Show member pathways
13.86 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
7
Show member pathways
13.86 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
8
Show member pathways
13.65 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
9
Show member pathways
13.63 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
10
Show member pathways
13.61 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
11
Show member pathways
13.53 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
12
Show member pathways
13.46 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
13
Show member pathways
13.42 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
14
Show member pathways
13.29 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
15
Show member pathways
13.19 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
16
Show member pathways
13.18 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
17
Show member pathways
13.16 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
18
Show member pathways
12.83 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
19 12.57 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
20 12.49 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
21
Show member pathways
12.39 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
22 12.35 H3C1 H3-3A EZH2 ATRX
23
Show member pathways
12.35 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
24 12.3 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
25
Show member pathways
12.12 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
26 12.11 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
27
Show member pathways
11.9 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
28 11.71 PDGFRA OLIG2 EZH2
29 11.62 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2

GO Terms for Childhood Brain Stem Glioma

Cellular components related to Childhood Brain Stem Glioma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.39 PDGFRA OLIG2 H3C8 H3C7 H3C6 H3C4
2 nucleoplasm GO:0005654 10.28 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
3 extracellular region GO:0005576 10.27 IDH1 H3C8 H3C7 H3C6 H3C4 H3C3
4 extracellular exosome GO:0070062 10.21 IDH1 H3C8 H3C7 H3C6 H3C4 H3C3
5 protein-containing complex GO:0032991 10.13 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
6 nuclear nucleosome GO:0000788 10.03 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
7 nuclear chromosome GO:0000228 9.97 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
8 nucleosome GO:0000786 9.8 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
9 nuclear chromosome, telomeric region GO:0000784 9.67 H3-3B H3-3A ATRX
10 chromosome GO:0005694 9.5 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
11 Barr body GO:0001740 9.48 H3-3B H3-3A

Biological processes related to Childhood Brain Stem Glioma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene silencing by miRNA GO:0060964 10.23 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
2 regulation of gene silencing GO:0060968 10.21 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
3 regulation of megakaryocyte differentiation GO:0045652 10.21 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
4 interleukin-7-mediated signaling pathway GO:0038111 10.19 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
5 DNA replication-dependent nucleosome assembly GO:0006335 10.18 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
6 cellular protein metabolic process GO:0044267 10.18 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
7 telomere organization GO:0032200 10.15 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
8 blood coagulation GO:0007596 10.1 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
9 chromatin silencing at rDNA GO:0000183 10.03 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
10 negative regulation of gene expression, epigenetic GO:0045814 9.97 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
11 nucleosome assembly GO:0006334 9.77 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
12 multicellular organism growth GO:0035264 9.75 H3-3B H3-3A ATRX
13 DNA replication-independent nucleosome assembly GO:0006336 9.7 H3-3B H3-3A ATRX
14 muscle cell differentiation GO:0042692 9.58 H3-3B H3-3A
15 pericentric heterochromatin assembly GO:0031508 9.57 H3-3B H3-3A
16 regulation of centromere complex assembly GO:0090230 9.56 H3-3B H3-3A
17 negative regulation of chromosome condensation GO:1902340 9.55 H3-3B H3-3A
18 telomeric heterochromatin assembly GO:0031509 9.54 H3-3B H3-3A
19 chromatin organization GO:0006325 9.44 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2

Molecular functions related to Childhood Brain Stem Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 10.09 OLIG2 H3C8 H3C7 H3C6 H3C4 H3C3
2 cadherin binding GO:0045296 9.73 IDH1 H3C8 H3C7 H3C6 H3C4 H3C3
3 protein heterodimerization activity GO:0046982 9.47 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
4 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.43 H3-3B H3-3A EZH2

Sources for Childhood Brain Stem Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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