MCID: CHL012
MIFTS: 46

Childhood Disintegrative Disease

Categories: Mental diseases, Neuronal diseases, Oral diseases, Rare diseases
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Aliases & Classifications for Childhood Disintegrative Disease

MalaCards integrated aliases for Childhood Disintegrative Disease:

Name: Childhood Disintegrative Disease 11 14
Childhood Disintegrative Disorder 19 58 75 71
Disintegrative Psychosis 11
Shared Paranoid Disorder 71
Symbiotic Psychosis 11
Dementia Infantilis 58
Heller's Syndrome 11
Heller Syndrome 58

Characteristics:


Age Of Onset:

Childhood Disintegrative Disorder: Childhood 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 11 DOID:13487
ICD9CM 34 299.1
NCIt 49 C97164
SNOMED-CT 68 71961003
ICD10 31 F84.3
ICD10 via Orphanet 32 F84.3
UMLS via Orphanet 72 C0236791
Orphanet 58 ORPHA168782
UMLS 71 C0036939 C0236791

Summaries for Childhood Disintegrative Disease

GARD: 19 Childhood disintergrative disorder is a rare pervasive developmental disorder with a disease onset before the age of three and characterized by a dramatic loss of behavioral and developmental functioning after atleast two years of normal development. Manifestations of the disease include loss of speech, incontinence, communication and social interaction problems, stereotypical autistic behaviors and dementia.

MalaCards based summary: Childhood Disintegrative Disease, also known as childhood disintegrative disorder, is related to asperger syndrome and atypical autism. An important gene associated with Childhood Disintegrative Disease is MECP2 (Methyl-CpG Binding Protein 2), and among its related pathways/superpathways are Transmission across Chemical Synapses and Neuroscience. The drugs Metamfetamine and Haloperidol have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are abnormal emotion/affect behavior and progressive language deterioration

Orphanet: 58 Childhood disintergrative disorder is a rare pervasive developmental disorder with a disease onset before the age of three and characterized by a dramatic loss of behavioral and developmental functioning after atleast two years of normal development. Manifestations of the disease include loss of speech, incontinence, communication and social interaction problems, stereotypical autistic behaviors and dementia.

Disease Ontology: 11 A pervasive developmental disorder that is a rare condition characterized by late onset (greater than 3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress.

Wikipedia: 75 Childhood disintegrative disorder (CDD), also known as Heller's syndrome and disintegrative psychosis,... more...

Related Diseases for Childhood Disintegrative Disease

Diseases related to Childhood Disintegrative Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 asperger syndrome 31.5 NLGN4X NLGN3 MECP2 GABRB3 BDNF
2 atypical autism 31.2 SHANK2 NRXN1 NLGN4X NLGN3 MECP2 GABRB3
3 rett syndrome 29.3 UBE3A MECP2 GABRB3 BDNF
4 psychotic disorder 28.7 SHANK2 NRXN3 NRXN2 NRXN1 MECP2 GABRB3
5 autism spectrum disorder 28.6 UBE3A SHANK2 NRXN3 NRXN2 NRXN1 NLGN4X
6 phelan-mcdermid syndrome 28.5 UBE3A SHANK2 NRXN3 NRXN2 NRXN1 NLGN4X
7 autism 28.1 UBE3A SHANK2 NRXN3 NRXN2 NRXN1 NLGN4X
8 pervasive developmental disorder 27.9 UBE3A SHANK2 NRXN3 NRXN2 NRXN1 NLGN4X
9 pitt-hopkins-like syndrome 10.3 NRXN1 CNTNAP2
10 valproate embryopathy 10.3 NLGN3 MECP2
11 chronic tic disorder 10.2 NRXN1 NLGN4X CNTNAP2
12 potocki-lupski syndrome 10.2 NRXN1 NLGN3 MECP2
13 syndromic x-linked intellectual disability najm type 10.2 NRXN2 NRXN1
14 timothy syndrome 10.1 SHANK2 NRXN1 MECP2
15 stereotypic movement disorder 10.1 NRXN1 NLGN4X NLGN3 MECP2
16 dissociative amnesia 10.1 CNTNAP2 BDNF
17 meier-gorlin syndrome 2 10.1 FMR1 CNTNAP2
18 epilepsy, idiopathic generalized 9 10.1 FMR1 CNTNAP2
19 mucopolysaccharidosis, type iiia 10.1
20 tay-sachs disease 10.1
21 hyperhomocysteinemia 10.1
22 developmental delay with or without dysmorphic facies and autism 10.1
23 vitamin b12 deficiency 10.1
24 physical disorder 10.1
25 gangliosidosis 10.1
26 gm2 gangliosidosis 10.1
27 mutism 10.1
28 encephalitis 10.1
29 rare pervasive developmental disorder 10.1
30 nmda receptor encephalitis 10.1
31 early-onset schizophrenia 10.1
32 anterograde amnesia 10.1 CNTNAP2 BDNF
33 schizophreniform disorder 10.0 NRXN1 BDNF
34 early infantile epileptic encephalopathy 10.0 NRXN1 MECP2 GABRB3 CNTNAP2
35 epilepsy 10.0
36 aphasia 10.0
37 apraxia 10.0
38 gait apraxia 10.0
39 measles 10.0
40 chromosome 22q11.2 deletion syndrome, distal 10.0 NRXN1 NLGN4X MECP2 FMR1
41 velocardiofacial syndrome 10.0 NRXN1 MECP2 FMR1 CNTNAP2
42 focal epilepsy 10.0 MECP2 CNTNAP2 BDNF
43 dravet syndrome 10.0 MECP2 GABRB3 CNTNAP2
44 familial adult myoclonic epilepsy 10.0
45 pitt-hopkins-like syndrome 2 10.0 NRXN3 NRXN2 NRXN1 NLGN4X CNTNAP2
46 dementia 9.9
47 childhood-onset schizophrenia 9.9
48 cerebral atrophy 9.9
49 tobacco addiction 9.9 NRXN3 NRXN1 BDNF
50 chromosomal duplication syndrome 9.9 MECP2 FMR1 BDNF

Graphical network of the top 20 diseases related to Childhood Disintegrative Disease:



Diseases related to Childhood Disintegrative Disease

Symptoms & Phenotypes for Childhood Disintegrative Disease

Human phenotypes related to Childhood Disintegrative Disease:

58 30 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormal emotion/affect behavior 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0100851
2 progressive language deterioration 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0007064
3 bowel incontinence 58 30 Frequent (33%) Frequent (79-30%)
HP:0002607
4 absent speech 58 30 Frequent (33%) Frequent (79-30%)
HP:0001344
5 anxiety 58 30 Frequent (33%) Frequent (79-30%)
HP:0000739
6 urinary incontinence 58 30 Frequent (33%) Frequent (79-30%)
HP:0000020
7 impaired social interactions 58 30 Frequent (33%) Frequent (79-30%)
HP:0000735
8 social and occupational deterioration 58 30 Frequent (33%) Frequent (79-30%)
HP:0007086
9 motor stereotypy 30 Frequent (33%) HP:0000733
10 developmental regression 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002376
11 intellectual disability, severe 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0010864
12 motor deterioration 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002333
13 dementia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000726
14 seizure 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001250
15 stereotypy 58 Frequent (79-30%)
16 mental deterioration 58 Very frequent (99-80%)
17 autistic behavior 58 Very frequent (99-80%)

MGI Mouse Phenotypes related to Childhood Disintegrative Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.77 BDNF CDH9 CNTNAP2 FMR1 GABRB3 MECP2
2 no phenotypic analysis MP:0003012 9.7 BDNF GABRB3 MECP2 NLGN3 NRXN3 SHANK2
3 behavior/neurological MP:0005386 9.44 BDNF CDH9 CNTNAP2 FMR1 GABRB3 MECP2

Drugs & Therapeutics for Childhood Disintegrative Disease

Drugs for Childhood Disintegrative Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metamfetamine Approved, Illicit, Withdrawn Phase 4 537-46-2 10836
2
Haloperidol Approved Phase 4 52-86-8 3559
3
Histamine Approved, Investigational Phase 4 51-45-6 774
4
Cinnarizine Approved, Investigational Phase 4 298-57-7 1547484
5
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
6
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
7
Dexmedetomidine Approved, Experimental, Vet_approved Phase 4 86347-14-0, 113775-47-6 68602 5311068
8
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
9
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 70-16-6 1130
10
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
11 Folate Phase 4
12 Vitamins Phase 4
13 Vitamin B9 Phase 4
14 Hormones Phase 4
15 Trace Elements Phase 4
16 Anti-Anxiety Agents Phase 4
17 Vitamin B1 Phase 4
18 Vitamin B Complex Phase 4
19 Calcium, Dietary Phase 4
20 Antiemetics Phase 4
21 Anesthetics, Intravenous Phase 4
22 Anticonvulsants Phase 4
23 Anesthetics, General Phase 4
24
Histamine phosphate Phase 4 51-74-1 134614
25 calcium channel blockers Phase 4
26
Haloperidol decanoate Phase 4 52919
27 Anesthetics Phase 4
28 Hypnotics and Sedatives Phase 4
29 Histamine H1 Antagonists Phase 4
30 GABA Modulators Phase 4
31 Histamine Antagonists Phase 4
32 Gastrointestinal Agents Phase 4
33 Micronutrients Phase 4
34 Thiamin Phase 4
35 Excitatory Amino Acid Antagonists Phase 4
36 Anesthetics, Dissociative Phase 4
37 Pharmaceutical Solutions Phase 4
38 Analgesics Phase 4
39 Adrenergic alpha-Agonists Phase 4
40 Adrenergic Agonists Phase 4
41 Adrenergic Agents Phase 4
42 N-Methylaspartate Phase 4
43 Analgesics, Non-Narcotic Phase 4
44
Calcium Nutraceutical Phase 4 7440-70-2 271
45
Dopamine Approved Phase 2, Phase 3 62-31-7, 51-61-6 681
46
Aripiprazole Approved, Investigational Phase 2, Phase 3 129722-12-9 60795
47 Neurotransmitter Agents Phase 2, Phase 3
48 Psychotropic Drugs Phase 2, Phase 3
49 Antipsychotic Agents Phase 2, Phase 3
50 Central Nervous System Stimulants Phase 2, Phase 3

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Therapeutic Effect Between Quetiapine and Haloperidol on the Treatment of Methamphetamine - Induced Psychosis Completed NCT01939093 Phase 4 Diazepam;Stugeron
2 A Randomized Control Trial Employing fMRI to Investigate the Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers Completed NCT05320991 Phase 4 Ketamine;Nacl 0.9%
3 Prevention of NMDA Antagonist-induced Psychosis and Memory Impairment in Children Completed NCT00205712 Phase 4 Ketamine;Dexmedetomidine
4 Substance Misuse To Psychosis for Stimulants (SToP-S)--An Early Assertive Pharmacotherapy Intervention Study Recruiting NCT03485417 Phase 2, Phase 3 Aripiprazole;Paliperidone
5 The Pharmaco-genetic and Brain Mechanisms Associated With Cannabis- Induced Psychosis Unknown status NCT01565174
6 Advanced Grandparental Age as a Risk Factor for Autism and Other Pervasive Developmental Disorders Completed NCT00464477
7 Effect of Individual Cognitive Stimulation at Home in Adults With Psychotic Disorders: Randomised Controlled Trial Completed NCT04783285
8 The Study of Pharmacological Treatment Pattern for Cannabis-induced Psychosis Completed NCT04945031
9 Prevention of Weight Gain in Early Psychoses Completed NCT01075295
10 Effectiveness of Intensive Lifestyle Interventions in the Management of Diabetes in Individuals With Psychosis Completed NCT01828931
11 Multicentric Descriptive Cross-sectional Study Evaluating Cocaine Users in Treatment Center Completed NCT01569347
12 ED to EPI: Using SMS (Text) Messaging to Improve the Transition From the Emergency Department to Early Psychosis Intervention for Young People With Psychosis Recruiting NCT04298450
13 The OPUS YOUNG Study. The Efficacy of Early Intervention Service Versus Treatment as Usual for Adolescents Aged 12 - 17 With First-episode Psychosis, a Pragmatic Randomized Clinical Trial Recruiting NCT04916626
14 The PROBAS-Study: Developing a Process-based and Modular Group Therapy for Acute Psychiatric Patients With Psychotic Symptoms: a Single-arm Feasibility Study Active, not recruiting NCT04874974
15 Longitudinal and Biological Study of Childhood Disintegrative Disorder Terminated NCT00004458

Search NIH Clinical Center for Childhood Disintegrative Disease

Genetic Tests for Childhood Disintegrative Disease

Anatomical Context for Childhood Disintegrative Disease

Organs/tissues related to Childhood Disintegrative Disease:

MalaCards : Brain

Publications for Childhood Disintegrative Disease

Articles related to Childhood Disintegrative Disease:

(show top 50) (show all 137)
# Title Authors PMID Year
1
Later onset of Childhood Disintegrative Disorder (CDD): a case report. 62
36369699 2022
2
Childhood Disintegrative Disorder (CDD): Symptomatology of the Norwegian Patient Population and Parents' Experiences of Patient Regression. 62
33934283 2022
3
The Characteristics and Results of Parent Training Interventions in Children with Autism Spectrum Disorder: A Systematic Review. 62
35865044 2022
4
Critical role of dysfunctional mitochondria and defective mitophagy in autism spectrum disorders. 62
33400955 2021
5
Clinical Relevance of Methylenetetrahydrofolate Reductase Genetic Testing in Autism: A Case Report of Successful Clinical Outcome. 62
33577628 2021
6
Childhood disintegrative disorder and autism spectrum disorder: a systematic review. 62
30548847 2019
7
Childhood disintegrative disorder: part of the autism spectrum? 62
30740653 2019
8
Two cases of variant late infantile ceroid lipofuscinosis in Jordan. 62
30705896 2019
9
De novo variant of TRRAP in a patient with very early onset psychosis in the context of non-verbal learning disability and obsessive-compulsive disorder: a case report. 62
30424743 2018
10
Identification of the Genetic Cause for Childhood Disintegrative Disorder by Whole-Exome Sequencing. 62
28283807 2017
11
Neurogenetic analysis of childhood disintegrative disorder. 62
28392909 2017
12
Autism Spectrum Disorder: Primary Care Principles. 62
28075089 2016
13
Trauma and Violence in Autism. 62
27236175 2016
14
CSF N-glycan profile reveals sialylation deficiency in a patient with GM2 gangliosidosis presenting as childhood disintegrative disorder. 62
26286102 2016
15
Childhood disintegrative disorder with seasonal total mutism: A rare clinical presentation. 62
27069898 2016
16
Childhood Disintegrative Disorder as a Complication of Chicken Pox. 62
27011406 2016
17
Case report: an unexpected link between partial deletion of the SHANK3 gene and Heller's dementia infantilis, a rare subtype of autism spectrum disorder. 62
26489495 2015
18
Approach to autism spectrum disorder: Using the new DSM-V diagnostic criteria and the CanMEDS-FM framework. 62
25971758 2015
19
Childhood disintegrative disorder: a case report. 62
26211118 2015
20
Psychosocial short stature with psychosis: a case report. 62
25520002 2015
21
[A late debut of childhood disintegrative disorder]. 62
25613094 2015
22
Recent update of autism spectrum disorders. 62
25729393 2015
23
A new structured interview for children with autism spectrum disorder based on the DSM-IV. 62
25518287 2014
24
[Autism spectrum disorders - epidemiology, symptoms, comorbidity and diagnosis]. 62
25314794 2014
25
Childhood disintegrative disorder: distinction from autistic disorder and predictors of outcome. 62
23340080 2013
26
Brief report: childhood disintegrative disorder as a likely manifestation of vitamin B12 deficiency. 62
23334842 2013
27
Autism, an overwhelming condition: history, etiopathogenesis, types, diagnosis, therapy and prognosis. 62
24502031 2013
28
Revisiting regression in autism: Heller's dementia infantilis. Includes a translation of Über Dementia Infantilis. 62
22677931 2013
29
Care of the patient with an autism spectrum disorder by the general physician. 62
22427366 2012
30
Co-morbidity and factor analysis on attention deficit hyperactivity disorder and autism spectrum disorder DSM-IV-derived items. 62
23267399 2012
31
[Anti-NMDA-receptor encephalitis: a new axis-III disorder in the differential diagnosis of childhood disintegrative disorder, early onset schizophrenia and late onset autism]. 62
22588963 2012
32
Autism and related disorders. 62
22608634 2012
33
Childhood disintegrative disorder. 62
22837782 2012
34
Brief report: childhood disintegrative disorder: a brief examination of eight case studies. 62
20607378 2011
35
Prevalence of pervasive developmental disorders among children at the English Montreal School Board. 62
21070699 2010
36
Catatonia is hidden in plain sight among different pediatric disorders: a review article. 62
20933172 2010
37
Late onset autistic symptoms and other fluctuating behaviors. 62
20414073 2010
38
Late onset autistic symptoms and other fluctuating behaviors. 62
19996905 2009
39
Genetic studies in children with intellectual disability and autistic spectrum of disorders. 62
21088714 2009
40
EEG and MRI findings and their relation with intellectual disability in pervasive developmental disorders. 62
19693463 2009
41
The quality of life of children with pervasive developmental disorders. 62
19752845 2009
42
Corticosteroid treatment of behaviour, language and motor regression in childhood disintegrative disorder. 62
18625572 2009
43
Epidemiology of pervasive developmental disorders. 62
19218885 2009
44
Epilepsy-aphasia syndromes. 62
19496686 2009
45
A case study of childhood disintegrative disorder using systematic analysis of family home movies. 62
18454311 2008
46
Understanding the autistic dental patient. 62
18348375 2008
47
[Pervasive developmental disorders. Clinical and genetics aspects]. 62
18422083 2007
48
[Non-autistic pervasive developmental disorders: Rett syndrome, disintegrative disorder and pervasive developmental disorder not otherwise specified]. 62
16791387 2006
49
Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy. 62
16181614 2006
50
Childhood Disintegrative Disorder, an atypical presentation: a case report. 62
16283078 2005

Variations for Childhood Disintegrative Disease

Expression for Childhood Disintegrative Disease

Search GEO for disease gene expression data for Childhood Disintegrative Disease.

Pathways for Childhood Disintegrative Disease

GO Terms for Childhood Disintegrative Disease

Cellular components related to Childhood Disintegrative Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 10.18 FMR1 GABRB3 MECP2 NLGN3 NLGN4X NRXN1
2 glutamatergic synapse GO:0098978 10.09 UBE3A SHANK2 NRXN2 NRXN1 CDH10
3 postsynaptic membrane GO:0045211 9.91 CDH9 FMR1 GABRB3 NLGN3 NLGN4X SHANK2
4 excitatory synapse GO:0060076 9.88 NRXN1 NLGN4X NLGN3
5 asymmetric, glutamatergic, excitatory synapse GO:0098985 9.83 NLGN4X NLGN3
6 symmetric, GABA-ergic, inhibitory synapse GO:0098983 9.8 NLGN4X NLGN3
7 anchoring junction GO:0070161 9.8 SHANK2 NLGN4X NLGN3 GABRB3 FMR1 CNTNAP2
8 inhibitory synapse GO:0060077 9.63 NRXN1 NLGN4X NLGN3
9 postsynaptic specialization membrane GO:0099634 9.61 NLGN4X NLGN3 CDH10
10 obsolete integral component of presynaptic active zone membrane GO:0099059 9.54 NRXN1 CDH10
11 obsolete integral component of postsynaptic specialization membrane GO:0099060 9.54 NLGN4X NLGN3 CDH10
12 obsolete spanning component of membrane GO:0089717 9.51 NLGN4X NLGN3
13 GABA-ergic synapse GO:0098982 9.43 NRXN3 NRXN1 NLGN4X NLGN3 CDH10
14 neuron to neuron synapse GO:0098984 9.33 NRXN1 NLGN4X NLGN3
15 presynapse GO:0098793 9.32 NRXN3 NRXN2 NRXN1 NLGN4X NLGN3 FMR1

Biological processes related to Childhood Disintegrative Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 10.21 NRXN3 NRXN2 NRXN1 NLGN4X NLGN3 MECP2
2 cell adhesion GO:0007155 10.15 NRXN3 NRXN2 NRXN1 NLGN4X NLGN3 CNTNAP2
3 learning GO:0007612 10.13 CNTNAP2 MECP2 NLGN3 NLGN4X NRXN1 NRXN3
4 synapse assembly GO:0007416 10.13 SHANK2 NRXN3 NRXN2 NRXN1 NLGN3 MECP2
5 cell-cell adhesion GO:0098609 10.08 NRXN3 NRXN2 NRXN1 CDH9 CDH10
6 positive regulation of synapse assembly GO:0051965 10.07 NRXN1 NLGN3 BDNF
7 neuron cell-cell adhesion GO:0007158 10.07 NRXN3 NRXN2 NRXN1 NLGN4X NLGN3
8 modulation of chemical synaptic transmission GO:0050804 10.05 UBE3A NLGN4X NLGN3 BDNF
9 postsynaptic membrane assembly GO:0097104 10.01 NLGN3 NLGN4X NRXN1 NRXN2
10 neuron projection morphogenesis GO:0048812 10 NRXN1 CNTNAP2 BDNF
11 adult behavior GO:0030534 10 CNTNAP2 NLGN3 NLGN4X NRXN1 NRXN2 NRXN3
12 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 9.97 CDH10 CDH9 NRXN1
13 neurotransmitter secretion GO:0007269 9.96 NRXN3 NRXN2 NRXN1
14 vocal learning GO:0042297 9.93 NRXN2 NRXN1 CNTNAP2
15 regulation of respiratory gaseous exchange by nervous system process GO:0002087 9.91 NLGN3 MECP2
16 postsynaptic density protein 95 clustering GO:0097119 9.88 NRXN2 NRXN1
17 presynaptic membrane assembly GO:0097105 9.88 NLGN3 NLGN4X NRXN1
18 gephyrin clustering involved in postsynaptic density assembly GO:0097116 9.87 NRXN2 NRXN1
19 social behavior GO:0035176 9.86 SHANK2 NRXN3 NRXN2 NRXN1 NLGN4X NLGN3
20 neuroligin clustering involved in postsynaptic membrane assembly GO:0097118 9.85 NRXN2 NRXN1
21 synaptic membrane adhesion GO:0099560 9.83 CDH10 CDH9 NRXN1
22 vocalization behavior GO:0071625 9.47 SHANK2 NRXN3 NRXN2 NRXN1 NLGN4X NLGN3

Molecular functions related to Childhood Disintegrative Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.72 NRXN3 NRXN2 NRXN1 GABRB3
2 siRNA binding GO:0035197 9.56 MECP2 FMR1
3 calcium channel regulator activity GO:0005246 9.55 NRXN3 NRXN2 NRXN1
4 neuroligin family protein binding GO:0097109 9.43 NRXN3 NRXN2 NRXN1
5 cell adhesion molecule binding GO:0050839 9.32 NRXN3 NRXN2 NRXN1 NLGN4X NLGN3

Sources for Childhood Disintegrative Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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