Childhood Electroclinical Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHL058 MIFTS: 25	Childhood Electroclinical Syndrome Categories: Neuronal diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Childhood Electroclinical Syndrome

MalaCards integrated aliases for Childhood Electroclinical Syndrome:

Name: Childhood Electroclinical Syndrome ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050704

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Summaries for Childhood Electroclinical Syndrome

Disease Ontology : ¹² An electroclinical syndrome with onset in childhood between one and 12 years of age.

MalaCards based summary : Childhood Electroclinical Syndrome is related to early onset absence epilepsy and lennox-gastaut syndrome. An important gene associated with Childhood Electroclinical Syndrome is GABRG2 (Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2), and among its related pathways/superpathways are Developmental Biology and G-Beta Gamma Signaling. Affiliated tissues include heart and temporal lobe, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and behavior/neurological

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Related Diseases for Childhood Electroclinical Syndrome

Diseases related to Childhood Electroclinical Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)

#	Related Disease	Score	Top Affiliating Genes
1	early onset absence epilepsy	31.6	SCN2A SCN1A KCNQ3 KCNQ2 GJA8 GABRG2
2	lennox-gastaut syndrome	30.4	STXBP1 SCN8A SCN2A SCN1A PCDH19 KCNQ3
3	childhood absence epilepsy	29.8	STXBP1 SCN8A SCN2A SCN1A PCDH19 KCNQ3
4	febrile infection-related epilepsy syndrome	10.6	SCN1A PCDH19
5	genetic epilepsy with febrile seizures plus	10.5	SCN2A SCN1A
6	familial febrile seizures	10.5	SCN1A GABRG2
7	sporadic hemiplegic migraine	10.5	SCN1A CACNA1A
8	myoclonic epilepsy of infancy	10.5	SCN8A SCN1A GABRG2
9	high pressure neurological syndrome	10.5	GRIN2A CACNA1H
10	familial or sporadic hemiplegic migraine	10.5	SCN1A CACNA1A
11	epileptic encephalopathy, early infantile, 13	10.5	SCN8A SCN1A
12	epilepsy, familial temporal lobe, 5	10.5	SCN1A GABRG2 GABRD
13	kcnq2-related disorders	10.5	KCNQ3 KCNQ2
14	seizures, benign familial infantile, 3	10.5	SCN2A KCNQ2
15	hereditary episodic ataxia	10.5	SCN2A CACNA1A
16	verbal auditory agnosia	10.5	GRIN2A GABRG2 ELP4
17	reflex epilepsy	10.5	SCN1A GABRG2
18	neuropathy, hereditary sensory and autonomic, type vii	10.5	SCN2A SCN1A
19	ohtahara syndrome	10.5	STXBP1 SCN2A
20	epileptic encephalopathy, childhood-onset	10.5	PCDH19 KCNQ2 GABRA1
21	low-grade astrocytoma	10.5	SCN8A SCN2A SCN1A
22	spinocerebellar ataxia 6	10.5	SCN1A CACNA1H CACNA1A
23	episodic ataxia, type 2	10.5	SCN1A CACNA1H CACNA1A
24	seizures, benign familial infantile, 5	10.5	SCN8A KCNQ3
25	spinocerebellar ataxia 27	10.4	SCN8A SCN1A CACNA1A
26	malignant migrating partial seizures of infancy	10.4	SCN2A SCN1A
27	hyperekplexia	10.4	GABRG2 GABRB3 GABRA1
28	seizures, benign familial neonatal, 2	10.4	KCNQ3 KCNQ2
29	epileptic encephalopathy, early infantile, 25, with amelogenesis imperfecta	10.4	SCN8A SCN1A
30	unverricht-lundborg syndrome	10.4	KCNQ3 GABRG2 EFHC1
31	central nervous system origin vertigo	10.4	SCN2A CACNA1A
32	paroxysmal dyskinesia	10.4	SCN8A PCDH19
33	progressive familial heart block, type ia	10.4	SCN8A SCN1A
34	febrile seizures	10.4	SCN2A SCN1A GABRG2 GABRD
35	epilepsy, nocturnal frontal lobe, 1	10.4	SCN1A KCNQ3 KCNQ2 GABRG2
36	epileptic encephalopathy, early infantile, 1	10.4	SCN1A KCNQ2 GABRB3 CACNA1A
37	episodic ataxia, type 1	10.3	KCNQ3 KCNQ2 CACNA1A
38	ceroid lipofuscinosis, neuronal, 4b, autosomal dominant	10.3	KCNQ3 KCNQ2
39	cataract 1, multiple types	10.3	GJA8 GABRG2
40	angelman syndrome	10.3	GABRG2 GABRB3 GABRA1 CDKL5
41	encephalopathy	10.3	STXBP1 SCN1A PCDH19 CDKL5
42	seizure disorder	10.3	SCN2A SCN1A KCNQ2 CDKL5
43	status epilepticus	10.3	SCN1A PCDH19 KCNQ2 CACNA1A
44	undetermined early-onset epileptic encephalopathy	10.3	STXBP1 SCN8A GABRG2 CACNA1A
45	epilepsy with generalized tonic-clonic seizures	10.3	SCN2A SCN1A GJA8 GABRG2 EFHC1
46	epileptic encephalopathy, early infantile, 7	10.3	STXBP1 SCN8A KCNQ3 KCNQ2
47	coffin-siris syndrome 4	10.2	SCN8A SCN2A
48	partial motor epilepsy	10.2	STXBP1 SCN2A SCN1A KCNQ2 CACNA1G
49	alacrima, achalasia, and mental retardation syndrome	10.2	STXBP1 SCN1A GRIN2A CACNA1A
50	cataract 14, multiple types	10.2	GJA8 GABRG2

Graphical network of the top 20 diseases related to Childhood Electroclinical Syndrome:

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Symptoms & Phenotypes for Childhood Electroclinical Syndrome

GenomeRNAi Phenotypes related to Childhood Electroclinical Syndrome according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Resistant to vaccinia virus (VACV-A4L) infection	GR00351-A-1	9.23	CACNA1G EFHC1 GABRA1 GRIN2A KCNQ2 SCN1A

MGI Mouse Phenotypes related to Childhood Electroclinical Syndrome:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.21	CACNA1A CACNA1G CACNA1H CDKL5 EFHC1 GABRA1
2	growth/size/body region	MP:0005378	9.93	CACNA1A CACNA1G CACNA1H GABRA1 GABRB3 GABRG2
3	nervous system	MP:0003631	9.89	CACNA1A CACNA1G CACNA1H CDKL5 EFHC1 GABRA1
4	reproductive system	MP:0005389	9.28	CACNA1A GABRA1 GABRB3 GABRD GABRG2 GJA8

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Drugs & Therapeutics for Childhood Electroclinical Syndrome

Search Clinical Trials , NIH Clinical Center for Childhood Electroclinical Syndrome

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Genetic Tests for Childhood Electroclinical Syndrome

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Anatomical Context for Childhood Electroclinical Syndrome

MalaCards organs/tissues related to Childhood Electroclinical Syndrome:

⁴⁰

Heart, Temporal Lobe

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Publications for Childhood Electroclinical Syndrome

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Genes for Childhood Electroclinical Syndrome

Genes related to Childhood Electroclinical Syndrome (0 elite genes):

(show all 34)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GABRG2	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2	Protein Coding	8.46	DISEASES inferred ¹⁵
2	SCN1A	Sodium Voltage-Gated Channel Alpha Subunit 1	Protein Coding	8.4	DISEASES inferred ¹⁵
3	CACNA1H	Calcium Voltage-Gated Channel Subunit Alpha1 H	Protein Coding	8.39	DISEASES inferred ¹⁵
4	GABRB3	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta3	Protein Coding	8.05	DISEASES inferred ¹⁵
5	GABRA1	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha1	Protein Coding	8.05	DISEASES inferred ¹⁵
6	EFHC1	EF-Hand Domain Containing 1	Protein Coding	7.8	DISEASES inferred ¹⁵
7	CACNA1G	Calcium Voltage-Gated Channel Subunit Alpha1 G	Protein Coding	7.76	DISEASES inferred ¹⁵
8	ELP4	Elongator Acetyltransferase Complex Subunit 4	Protein Coding	7.58	DISEASES inferred ¹⁵
9	SCN8A	Sodium Voltage-Gated Channel Alpha Subunit 8	Protein Coding	7.51	DISEASES inferred ¹⁵
10	KCNQ2	Potassium Voltage-Gated Channel Subfamily Q Member 2	Protein Coding	7.47	DISEASES inferred ¹⁵
11	CACNA1I	Calcium Voltage-Gated Channel Subunit Alpha1 I	Protein Coding	7.45	DISEASES inferred ¹⁵
12	GJA8	Gap Junction Protein Alpha 8	Protein Coding	7.45	DISEASES inferred ¹⁵
13	GABRD	Gamma-Aminobutyric Acid Type A Receptor Subunit Delta	Protein Coding	7.44	DISEASES inferred ¹⁵
14	PCDH19	Protocadherin 19	Protein Coding	7.39	DISEASES inferred ¹⁵
15	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	7.37	DISEASES inferred ¹⁵
16	SCN2A	Sodium Voltage-Gated Channel Alpha Subunit 2	Protein Coding	7.36	DISEASES inferred ¹⁵
17	STXBP1	Syntaxin Binding Protein 1	Protein Coding	7.32	DISEASES inferred ¹⁵
18	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	7.17	DISEASES inferred ¹⁵
19	CDKL5	Cyclin Dependent Kinase Like 5	Protein Coding	7.15	DISEASES inferred ¹⁵
20	KCNQ3	Potassium Voltage-Gated Channel Subfamily Q Member 3	Protein Coding	7.15	DISEASES inferred ¹⁵
21	SLC6A1	Solute Carrier Family 6 Member 1	Protein Coding	7.1	DISEASES inferred ¹⁵
22	SCN1B	Sodium Voltage-Gated Channel Beta Subunit 1	Protein Coding	7.1	DISEASES inferred ¹⁵
23	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	7.04	DISEASES inferred ¹⁵
24	CLCN2	Chloride Voltage-Gated Channel 2	Protein Coding	7.03	DISEASES inferred ¹⁵
25	KCNT1	Potassium Sodium-Activated Channel Subfamily T Member 1	Protein Coding	7.03	DISEASES inferred ¹⁵
26	MLST8	MTOR Associated Protein, LST8 Homolog	Protein Coding	6.9	DISEASES inferred ¹⁵
27	PCDH10	Protocadherin 10	Protein Coding	6.84	DISEASES inferred ¹⁵
28	POMC	Proopiomelanocortin	Protein Coding	6.83	DISEASES inferred ¹⁵
29	SRPX2	Sushi Repeat Containing Protein X-Linked 2	Protein Coding	6.81	DISEASES inferred ¹⁵
30	CACNG3	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3	Protein Coding	6.79	DISEASES inferred ¹⁵
31	CACNB4	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4	Protein Coding	6.78	DISEASES inferred ¹⁵
32	GABRR3	Gamma-Aminobutyric Acid Type A Receptor Subunit Rho3 (Gene/Pseudogene)	Protein Coding	6.77	DISEASES inferred ¹⁵
33	PVALB	Parvalbumin	Protein Coding	6.71	DISEASES inferred ¹⁵
34	GABRA5	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha5	Protein Coding	6.69	DISEASES inferred ¹⁵

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Variations for Childhood Electroclinical Syndrome

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Expression for Childhood Electroclinical Syndrome

Search GEO for disease gene expression data for Childhood Electroclinical Syndrome.

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Pathways for Childhood Electroclinical Syndrome

Pathways related to Childhood Electroclinical Syndrome according to GeneCards Suite gene sharing:

(show all 25)

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁵ Show member pathways Axon guidance ⁶⁵	13.38	SCN8A SCN2A SCN1A KCNQ3 KCNQ2 GRIN2A
2	G-Beta Gamma Signaling ⁶³ Show member pathways CRHR Pathway ⁶³ GHRH Signaling ⁶³ Hedgehog Signaling in Mammals ⁶³ Relaxin Pathway ⁶³ Signaling in Gap Junctions ⁶³	12.93	SCN8A SCN2A SCN1A GJA8 CACNA1I CACNA1H
3	Sweet Taste Signaling ⁶³ Show member pathways Bitter Taste Signaling ⁶³ Cellular Effects of Sildenafil ⁶³ Melatonin Signaling ⁶³ Sperm Motility ⁶³	12.91	GABRG2 GABRD GABRB3 GABRA1 CDKL5 CACNA1I
4	Transmission across Chemical Synapses ⁶⁵ Show member pathways Neuronal System ⁶⁵ Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ⁶⁵	12.86	STXBP1 KCNQ3 KCNQ2 GRIN2A GABRG2 GABRB3
5	Circadian entrainment ³⁶ Show member pathways Cholinergic synapse ³⁶ Dopaminergic synapse ³⁶ Glutamatergic synapse ³⁶ Synaptic Neurotransmission Pathways: Glutamatergic Excitation ⁶⁴	12.59	SCN1A KCNQ3 KCNQ2 GRIN2A CACNA1I CACNA1H
6	Neuroscience ⁴	12.49	STXBP1 SCN8A SCN2A SCN1A KCNQ2 GRIN2A
7	GABAergic synapse ³⁶ Show member pathways Morphine addiction ³⁶ Retrograde endocannabinoid signaling ³⁶	12.47	GABRG2 GABRD GABRB3 GABRA1 CACNA1A
8	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.33	GABRG2 GABRD GABRB3 GABRA1
9	Dopamine-DARPP32 Feedback onto cAMP Pathway ⁶³	12.25	KCNQ3 KCNQ2 GRIN2A CACNA1A
10	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.21	CACNA1I CACNA1H CACNA1G CACNA1A
11	Calcium signaling pathway ³⁶ Show member pathways Oxytocin signaling ¹	12.19	GRIN2A CACNA1I CACNA1H CACNA1G CACNA1A
12	Presenilin-Mediated Signaling ⁶³	12	CACNA1I CACNA1H CACNA1G CACNA1A
13	Fc-GammaR Pathway ⁶³ Show member pathways Fc-Gamma-RIIB Signaling in B-Cells ⁶³	11.94	CACNA1I CACNA1H CACNA1G CACNA1A
14	L1CAM interactions ⁶⁵ Show member pathways CHL1 interactions ⁶⁵ Neurofascin interactions ⁶⁵ NrCAM interactions ⁶⁵	11.93	SCN8A SCN2A SCN1A KCNQ3 KCNQ2
15	Taste transduction ³⁶ Show member pathways Class C/3 (Metabotropic glutamate/pheromone receptors) ⁶⁵	11.89	SCN2A GABRA1 CACNA1A
16	Phase 0 - rapid depolarisation ⁶⁵ Show member pathways Phase 2 - plateau phase ⁶⁵	11.65	SCN8A SCN2A SCN1A
17	G-protein signaling_RhoA regulation pathway ²²	11.61	CACNA1I CACNA1H CACNA1G CACNA1A
18	GnRH secretion ³⁶	11.56	CACNA1I CACNA1H CACNA1G
19	Ligand-gated ion channel transport ⁶⁵ Show member pathways GABA A (rho) receptor activation ⁶⁵ GABA A receptor activation ⁶⁵	11.37	GABRG2 GABRB3 GABRA1
20	NCAM1 interactions ⁶⁵	11.28	CACNA1I CACNA1H CACNA1G
21	Celecoxib Pathway, Pharmacodynamics ⁶⁰	11.2	KCNQ3 KCNQ2 CACNA1I CACNA1H CACNA1G CACNA1A
22	Interaction between L1 and Ankyrins ⁶⁵	11.03	SCN8A SCN2A SCN1A KCNQ3 KCNQ2
23	Benzodiazepine Pathway, Pharmacodynamics ⁶⁰ Show member pathways Reuptake of GABA ⁶⁵	10.87	GABRG2 GABRA1
24	Synaptic Neurotransmission Pathways: GABAergic Inhibition ⁶⁴	10.79	GABRG2 GABRD GABRB3 GABRA1
25	Nicotine addiction ³⁶	10.7	GRIN2A GABRG2 GABRD GABRB3 GABRA1 CACNA1A

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GO Terms for Childhood Electroclinical Syndrome

Cellular components related to Childhood Electroclinical Syndrome according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane	GO:0016020	10.45	STXBP1 SCN8A SCN2A SCN1A PCDH19 KCNQ3
2	integral component of membrane	GO:0016021	10.34	SCN8A SCN2A SCN1A PCDH19 KCNQ3 KCNQ2
3	plasma membrane	GO:0005886	10.19	STXBP1 SCN8A SCN2A SCN1A PCDH19 KCNQ3
4	integral component of plasma membrane	GO:0005887	10.11	SCN2A PCDH19 KCNQ3 KCNQ2 GRIN2A GJA8
5	cell junction	GO:0030054	10.09	SCN8A GRIN2A GJA8 GABRG2 GABRD GABRB3
6	neuron projection	GO:0043005	9.97	GRIN2A GABRG2 GABRD GABRB3 GABRA1
7	axon	GO:0030424	9.97	STXBP1 SCN8A SCN2A SCN1A GABRG2
8	glutamatergic synapse	GO:0098978	9.97	STXBP1 SCN2A GRIN2A GABRD CDKL5 CACNA1A
9	postsynaptic membrane	GO:0045211	9.93	GRIN2A GABRG2 GABRD GABRB3 GABRA1
10	cytoplasmic vesicle membrane	GO:0030659	9.86	GRIN2A GABRG2 GABRB3 GABRA1
11	synapse	GO:0045202	9.85	KCNQ3 KCNQ2 GRIN2A GABRG2 GABRD GABRB3
12	GABA-ergic synapse	GO:0098982	9.81	GABRG2 GABRD GABRB3 GABRA1
13	postsynapse	GO:0098794	9.77	STXBP1 GABRG2 GABRA1
14	chloride channel complex	GO:0034707	9.76	GABRG2 GABRD GABRB3 GABRA1
15	voltage-gated calcium channel complex	GO:0005891	9.71	CACNA1I CACNA1H CACNA1G CACNA1A
16	GABA-A receptor complex	GO:1902711	9.65	GABRG2 GABRB3 GABRA1
17	axon initial segment	GO:0043194	9.62	SCN8A SCN1A KCNQ3 KCNQ2
18	sodium channel complex	GO:0034706	9.58	SCN2A SCN1A
19	node of Ranvier	GO:0033268	9.35	SCN8A SCN2A SCN1A KCNQ3 KCNQ2
20	voltage-gated sodium channel complex	GO:0001518	9.1	SCN8A SCN2A SCN1A CACNA1I CACNA1H CACNA1G

Biological processes related to Childhood Electroclinical Syndrome according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane transport	GO:0055085	10.13	SCN8A SCN2A SCN1A KCNQ3 KCNQ2 GJA8
2	chemical synaptic transmission	GO:0007268	10.06	KCNQ3 KCNQ2 GRIN2A GABRG2 GABRD GABRB3
3	calcium ion transport	GO:0006816	9.97	GRIN2A CACNA1I CACNA1H CACNA1G CACNA1A
4	calcium ion transmembrane transport	GO:0070588	9.96	GRIN2A CACNA1I CACNA1H CACNA1G CACNA1A
5	sodium ion transmembrane transport	GO:0035725	9.93	SCN8A SCN2A SCN1A CACNA1I CACNA1H CACNA1G
6	regulation of ion transmembrane transport	GO:0034765	9.91	SCN8A SCN2A SCN1A KCNQ3 KCNQ2 CACNA1I
7	chloride transmembrane transport	GO:1902476	9.89	GABRG2 GABRD GABRB3 GABRA1
8	chloride transport	GO:0006821	9.88	GABRG2 GABRD GABRB3 GABRA1
9	regulation of postsynaptic membrane potential	GO:0060078	9.88	GRIN2A GABRG2 GABRD GABRA1
10	nervous system process	GO:0050877	9.88	GABRG2 GABRD GABRB3 GABRA1 CACNA1A
11	neuronal action potential	GO:0019228	9.85	SCN8A SCN2A SCN1A CACNA1I CACNA1H CACNA1G
12	gamma-aminobutyric acid signaling pathway	GO:0007214	9.83	GABRG2 GABRB3 GABRA1 CACNA1A
13	calcium ion import	GO:0070509	9.81	CACNA1I CACNA1H CACNA1G CACNA1A
14	regulation of membrane potential	GO:0042391	9.81	SCN1A GRIN2A GABRG2 GABRD GABRB3 GABRA1
15	positive regulation of calcium ion-dependent exocytosis	GO:0045956	9.8	STXBP1 CACNA1I CACNA1H CACNA1G
16	membrane depolarization during action potential	GO:0086010	9.8	SCN8A SCN2A SCN1A CACNA1I CACNA1H CACNA1G
17	sodium ion transport	GO:0006814	9.79	SCN8A SCN2A SCN1A
18	inhibitory synapse assembly	GO:1904862	9.72	GABRG2 GABRB3 GABRA1
19	cellular response to histamine	GO:0071420	9.71	GABRG2 GABRB3 GABRA1
20	ion transmembrane transport	GO:0034220	9.7	SCN8A SCN2A SCN1A GRIN2A GABRG2 GABRD
21	cardiac muscle cell action potential involved in contraction	GO:0086002	9.61	SCN1A CACNA1G
22	synaptic transmission, GABAergic	GO:0051932	9.61	GABRG2 GABRA1
23	sleep	GO:0030431	9.6	GRIN2A CACNA1I
24	ion transport	GO:0006811	9.47	SCN8A SCN2A SCN1A KCNQ3 KCNQ2 GRIN2A

Molecular functions related to Childhood Electroclinical Syndrome according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	chloride channel activity	GO:0005254	9.8	GABRG2 GABRD GABRB3 GABRA1
2	calcium channel activity	GO:0005262	9.8	GRIN2A CACNA1I CACNA1H CACNA1G CACNA1A
3	extracellular ligand-gated ion channel activity	GO:0005230	9.76	GABRG2 GABRD GABRB3 GABRA1
4	voltage-gated calcium channel activity	GO:0005245	9.73	CACNA1I CACNA1H CACNA1G CACNA1A
5	sodium channel activity	GO:0005272	9.69	SCN8A SCN2A SCN1A
6	GABA-gated chloride ion channel activity	GO:0022851	9.65	GABRG2 GABRB3 GABRA1
7	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	GO:1904315	9.65	GRIN2A GABRG2 GABRD GABRB3 GABRA1
8	voltage-gated sodium channel activity	GO:0005248	9.63	SCN8A SCN2A SCN1A CACNA1I CACNA1H CACNA1G
9	GABA-A receptor activity	GO:0004890	9.62	GABRG2 GABRD GABRB3 GABRA1
10	voltage-gated ion channel activity	GO:0005244	9.61	SCN8A SCN2A SCN1A KCNQ3 KCNQ2 CACNA1I
11	benzodiazepine receptor activity	GO:0008503	9.54	GABRG2 GABRA1
12	low voltage-gated calcium channel activity	GO:0008332	9.54	CACNA1I CACNA1H CACNA1G
13	inhibitory extracellular ligand-gated ion channel activity	GO:0005237	9.52	GABRG2 GABRA1
14	ion channel activity	GO:0005216	9.4	SCN8A SCN2A SCN1A GRIN2A GABRG2 GABRD

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Sources for Childhood Electroclinical Syndrome

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