MCID: CHL049
MIFTS: 19

Childhood Endodermal Sinus Tumor

Categories: Cancer diseases

Aliases & Classifications for Childhood Endodermal Sinus Tumor

MalaCards integrated aliases for Childhood Endodermal Sinus Tumor:

Name: Childhood Endodermal Sinus Tumor 12 15
Childhood Endodermal Sinus Neoplasm 12
Childhood Endodermal Sinus Tumour 12
Paediatric Yolk Sac Tumour 12
Pediatric Yolk Sac Tumor 12
Childhood Yolk Sac Tumor 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5342
NCIt 50 C27364
UMLS 70 C1333016

Summaries for Childhood Endodermal Sinus Tumor

Disease Ontology : 12 An endodermal sinus tumor that occurs in children.

MalaCards based summary : Childhood Endodermal Sinus Tumor, also known as childhood endodermal sinus neoplasm, is related to dysgerminoma and dysgerminoma of ovary. An important gene associated with Childhood Endodermal Sinus Tumor is ILF2 (Interleukin Enhancer Binding Factor 2). Related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Childhood Endodermal Sinus Tumor

Graphical network of the top 20 diseases related to Childhood Endodermal Sinus Tumor:



Diseases related to Childhood Endodermal Sinus Tumor

Symptoms & Phenotypes for Childhood Endodermal Sinus Tumor

GenomeRNAi Phenotypes related to Childhood Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.96 CDK11A ILF2 ILF3
2 Increased Nanog expression GR00371-A-2 9.96 CDK11A
3 Increased Nanog expression GR00371-A-3 9.96 CDK11A ILF2 ILF3
4 Increased Nanog expression GR00371-A-4 9.96 ILF3
5 Increased Nanog expression GR00371-A-5 9.96 CDK11A ILF3
6 Increased viability with 4OH tamoxifen GR00200-A 8.62 CDK11A CDK11B

Drugs & Therapeutics for Childhood Endodermal Sinus Tumor

Search Clinical Trials , NIH Clinical Center for Childhood Endodermal Sinus Tumor

Genetic Tests for Childhood Endodermal Sinus Tumor

Anatomical Context for Childhood Endodermal Sinus Tumor

Publications for Childhood Endodermal Sinus Tumor

Articles related to Childhood Endodermal Sinus Tumor:

# Title Authors PMID Year
1
RNA-binding protein LIN28 is a sensitive marker of pediatric yolk sac tumors. 61
27357399 2016
2
[Treatment of endodermal sinus tumor in children]. 61
24568900 2014
3
PAX8 and PAX2 immunostaining facilitates the diagnosis of primary epithelial neoplasms of the male genital tract. 61
21934480 2011
4
Cytodiagnosis of yolk sac tumor. 61
15531841 2004

Variations for Childhood Endodermal Sinus Tumor

Expression for Childhood Endodermal Sinus Tumor

Search GEO for disease gene expression data for Childhood Endodermal Sinus Tumor.

Pathways for Childhood Endodermal Sinus Tumor

GO Terms for Childhood Endodermal Sinus Tumor

Biological processes related to Childhood Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell growth GO:0001558 9.26 CDK11B CDK11A
2 SMAD protein signal transduction GO:0060395 9.16 GDF3 AFP
3 regulation of mitotic cell cycle GO:0007346 8.96 CDK11B CDK11A
4 regulation of mRNA processing GO:0050684 8.62 CDK11B CDK11A

Molecular functions related to Childhood Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded RNA binding GO:0003725 8.96 ILF3 ILF2
2 cyclin-dependent protein serine/threonine kinase activity GO:0004693 8.62 CDK11B CDK11A

Sources for Childhood Endodermal Sinus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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