MCID: CHL049
MIFTS: 24

Childhood Endodermal Sinus Tumor

Categories: Cancer diseases

Aliases & Classifications for Childhood Endodermal Sinus Tumor

MalaCards integrated aliases for Childhood Endodermal Sinus Tumor:

Name: Childhood Endodermal Sinus Tumor 12 15
Childhood Endodermal Sinus Neoplasm 12
Pediatric Yolk Sac Tumor 12
Childhood Yolk Sac Tumor 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5342
NCIt 51 C27364
UMLS 74 C1333016

Summaries for Childhood Endodermal Sinus Tumor

Disease Ontology : 12 An endodermal sinus tumor that occurs in children.

MalaCards based summary : Childhood Endodermal Sinus Tumor, also known as childhood endodermal sinus neoplasm, is related to endodermal sinus tumor and germ cell and embryonal cancer. An important gene associated with Childhood Endodermal Sinus Tumor is LIN28A (Lin-28 Homolog A), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include testis, kidney and prostate, and related phenotypes are endocrine/exocrine gland and reproductive system

Related Diseases for Childhood Endodermal Sinus Tumor

Graphical network of the top 20 diseases related to Childhood Endodermal Sinus Tumor:



Diseases related to Childhood Endodermal Sinus Tumor

Symptoms & Phenotypes for Childhood Endodermal Sinus Tumor

MGI Mouse Phenotypes related to Childhood Endodermal Sinus Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.26 AFP LIN28A PAX2 PAX8
2 reproductive system MP:0005389 8.92 AFP LIN28A PAX2 PAX8

Drugs & Therapeutics for Childhood Endodermal Sinus Tumor

Search Clinical Trials , NIH Clinical Center for Childhood Endodermal Sinus Tumor

Genetic Tests for Childhood Endodermal Sinus Tumor

Anatomical Context for Childhood Endodermal Sinus Tumor

MalaCards organs/tissues related to Childhood Endodermal Sinus Tumor:

42
Testis, Kidney, Prostate

Publications for Childhood Endodermal Sinus Tumor

Variations for Childhood Endodermal Sinus Tumor

Expression for Childhood Endodermal Sinus Tumor

Search GEO for disease gene expression data for Childhood Endodermal Sinus Tumor.

Pathways for Childhood Endodermal Sinus Tumor

Pathways related to Childhood Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 AFP LIN28A PAX2
2 10.92 AFP LIN28A PAX2
3 10.36 PAX2 PAX8

GO Terms for Childhood Endodermal Sinus Tumor

Biological processes related to Childhood Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 transcription, DNA-templated GO:0006351 9.6 PAX2 PAX8
2 inner ear morphogenesis GO:0042472 9.59 PAX2 PAX8
3 cellular response to glucose stimulus GO:0071333 9.58 LIN28A PAX2
4 branching involved in ureteric bud morphogenesis GO:0001658 9.58 PAX2 PAX8
5 stem cell differentiation GO:0048863 9.57 LIN28A PAX2
6 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.56 PAX2 PAX8
7 urogenital system development GO:0001655 9.55 PAX2 PAX8
8 mesonephros development GO:0001823 9.54 PAX2 PAX8
9 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.52 PAX2 PAX8
10 pronephros development GO:0048793 9.51 PAX2 PAX8
11 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.49 PAX2 PAX8
12 metanephric epithelium development GO:0072207 9.48 PAX2 PAX8
13 metanephric distal convoluted tubule development GO:0072221 9.46 PAX2 PAX8
14 metanephric nephron tubule formation GO:0072289 9.43 PAX2 PAX8
15 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.4 PAX2 PAX8
16 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.37 PAX2 PAX8
17 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.32 PAX2 PAX8
18 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.26 PAX2 PAX8
19 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX2 PAX8
20 positive regulation of metanephric DCT cell differentiation GO:2000594 8.96 PAX2 PAX8
21 pronephric field specification GO:0039003 8.62 PAX2 PAX8

Molecular functions related to Childhood Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 8.62 PAX2 PAX8

Sources for Childhood Endodermal Sinus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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