MCID: CHL010
MIFTS: 41

Childhood Kidney Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Childhood Kidney Cell Carcinoma

MalaCards integrated aliases for Childhood Kidney Cell Carcinoma:

Name: Childhood Kidney Cell Carcinoma 12 15
Pediatric Renal Cell Carcinoma 12
Childhood Renal Cell Carcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4454
NCIt 51 C6568
UMLS 74 C1333001

Summaries for Childhood Kidney Cell Carcinoma

MalaCards based summary : Childhood Kidney Cell Carcinoma, also known as pediatric renal cell carcinoma, is related to renal cell carcinoma, nonpapillary and central nervous system mesenchymal non-meningothelial tumor, and has symptoms including flank pain An important gene associated with Childhood Kidney Cell Carcinoma is TPM3 (Tropomyosin 3), and among its related pathways/superpathways are Endometrial cancer and Glioma. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and liver, and related phenotypes are cellular and mortality/aging

Related Diseases for Childhood Kidney Cell Carcinoma

Diseases related to Childhood Kidney Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 renal cell carcinoma, nonpapillary 30.0 MITF PAX2 PRCC TFE3 TFEB TSC2
2 central nervous system mesenchymal non-meningothelial tumor 10.3 FOXO1 PAX3
3 waardenburg syndrome, type 3 10.3 MITF PAX3
4 waardenburg syndrome, type 4b 10.3 MITF PAX3
5 appendix carcinoid tumor 10.3 MLH1 MSH2
6 colorectal cancer, hereditary nonpolyposis, type 7 10.3 MLH1 MSH2
7 adenosquamous colon carcinoma 10.3 MLH1 MSH2
8 sebaceous adenoma 10.3 MLH1 MSH2
9 lower lip cancer 10.3 MLH1 MSH2
10 anal fistula 10.3 MLH1 MSH2
11 pleomorphic rhabdomyosarcoma 10.3 FOXO1 PAX3
12 tietz albinism-deafness syndrome 10.3 MITF PAX3
13 clear cell papillary renal cell carcinoma 10.3 MITF TFE3
14 kidney benign neoplasm 10.2 PAX2 TSC2
15 rhabdomyosarcoma 2 10.2 ALK FOXO1 PAX3
16 mismatch repair cancer syndrome 10.2 MLH1 MSH2 PAX3
17 autosomal genetic disease 10.1 MLH1 MSH2 TSC2
18 waardenburg's syndrome 10.1 MITF PAX3 TFE3
19 autosomal dominant disease 10.1 MLH1 MSH2 PAX3
20 melanocytic nevus syndrome, congenital 10.1 MLH1 MSH2
21 waardenburg syndrome, type 2a 10.1 MITF TFE3 TFEB
22 lung papillary adenocarcinoma 10.1 ALK EML4
23 rhabdomyosarcoma 10.0 ALK FOXO1 MSH2 PAX3
24 inflammatory myofibroblastic tumor 10.0 ALK EML4 TPM3
25 lung adenoid cystic carcinoma 10.0 ALK EML4
26 alveolar soft part sarcoma 10.0 ASPSCR1 MLH1 TFE3
27 mesenchymal cell neoplasm 10.0 ALK TPM3
28 muscle cancer 9.9 ASPSCR1 FOXO1 PAX3 TFE3
29 skeletal muscle cancer 9.9 ASPSCR1 FOXO1 PAX3 TFE3
30 mucinous tubular and spindle renal cell carcinoma 9.9 PRCC TFE3
31 renal cell carcinoma, papillary, 1 9.9 MITF MSH2 PRCC TFE3
32 microphthalmia 9.8 MITF PAX2 PAX3 TFE3 TFEB
33 leiomyosarcoma 9.8
34 heart leiomyosarcoma 9.8
35 muscular disease 9.8 ASPSCR1 FOXO1 PAX3 TFE3 TPM3
36 renal cell carcinoma, xp11-associated 9.7 ASPSCR1 PRCC TFE3 TFEB

Graphical network of the top 20 diseases related to Childhood Kidney Cell Carcinoma:



Diseases related to Childhood Kidney Cell Carcinoma

Symptoms & Phenotypes for Childhood Kidney Cell Carcinoma

UMLS symptoms related to Childhood Kidney Cell Carcinoma:


flank pain

MGI Mouse Phenotypes related to Childhood Kidney Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 F3 FOXO1 GPX7 MITF MLH1 MSH2
2 mortality/aging MP:0010768 10.1 ALK F3 FOXO1 GPX7 MITF MLH1
3 integument MP:0010771 10.02 ALK F3 FOXO1 MITF MLH1 MSH2
4 embryo MP:0005380 9.97 F3 FOXO1 MITF PAX2 PAX3 TFEB
5 neoplasm MP:0002006 9.76 ALK F3 FOXO1 GPX7 MLH1 MSH2
6 pigmentation MP:0001186 9.43 ALK MITF PAX2 PAX3 TFE3 TFEB
7 vision/eye MP:0005391 9.23 ALK F3 MITF MLH1 PAX2 PAX3

Drugs & Therapeutics for Childhood Kidney Cell Carcinoma

Drugs for Childhood Kidney Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 38904 498142
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
4
Etoposide Approved Phase 2,Phase 1 33419-42-0 36462
5
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
6
Dactinomycin Approved, Investigational Phase 2 50-76-0 457193 2019
7
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
8
Fludarabine Approved Phase 1, Phase 2,Phase 2,Not Applicable 75607-67-9, 21679-14-1 30751
9
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2,Phase 2,Not Applicable 22916-47-8 4189
10
Mycophenolic acid Approved Phase 1, Phase 2,Phase 2,Not Applicable 24280-93-1 446541
11
Vidarabine Approved, Investigational Phase 1, Phase 2,Phase 2,Not Applicable 24356-66-9 21704 32326
12
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
13
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
14
Mechlorethamine Approved, Investigational Phase 1, Phase 2 51-75-2 4033
15
Doxil Approved June 1999 Phase 2 31703
16 topoisomerase I inhibitors Phase 2
17 Antimitotic Agents Phase 2
18 Alkylating Agents Phase 2,Phase 1
19 Antineoplastic Agents, Alkylating Phase 2,Phase 1
20 Immunosuppressive Agents Phase 2,Phase 1,Not Applicable
21 Anti-Infective Agents Phase 2,Phase 1,Not Applicable
22 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
23 Antirheumatic Agents Phase 2,Phase 1,Not Applicable
24 Etoposide phosphate Phase 2,Phase 1
25 Immunologic Factors Phase 2,Phase 1,Not Applicable
26 Antibiotics, Antitubercular Phase 2,Phase 1,Not Applicable
27 Nucleic Acid Synthesis Inhibitors Phase 2
28 Anti-Bacterial Agents Phase 2,Phase 1,Not Applicable
29 Topoisomerase Inhibitors Phase 2,Phase 1
30 Liver Extracts Phase 1, Phase 2
31 Cyclosporins Phase 1, Phase 2,Phase 2,Not Applicable
32 Vidarabine Phosphate Phase 1, Phase 2,Phase 2,Not Applicable
33 Antimetabolites, Antineoplastic Phase 1, Phase 2,Phase 2,Not Applicable
34 Antiviral Agents Phase 1, Phase 2,Phase 2,Not Applicable
35 Antitubercular Agents Phase 1, Phase 2,Phase 2,Not Applicable
36 Antifungal Agents Phase 1, Phase 2,Phase 2,Not Applicable
37 Calcineurin Inhibitors Phase 1, Phase 2,Phase 2,Not Applicable
38 Dermatologic Agents Phase 1, Phase 2,Phase 2,Not Applicable
39 Antimetabolites Phase 1, Phase 2,Phase 2,Not Applicable
40 Protein Kinase Inhibitors Phase 1, Phase 2
41
Isophosphamide mustard Phase 1, Phase 2 0
42
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
43
Mesna Approved, Investigational Phase 1 3375-50-6 598
44
Busulfan Approved, Investigational Phase 1 55-98-1 2478
45
Lenograstim Approved, Investigational Phase 1 135968-09-1
46
Melphalan Approved Phase 1 148-82-3 460612 4053
47
Thiotepa Approved, Investigational Phase 1 52-24-4 5453
48 Cola Phase 1
49 Vaccines Phase 1
50 Protective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Completed NCT00335556 Phase 2 Doxorubicin Hydrochloride;Irinotecan Hydrochloride;Cyclophosphamide;Etoposide;Carboplatin;Vincristine Sulfate
2 Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer Active, not recruiting NCT00027820 Phase 1, Phase 2 Fludarabine Phosphate;Cyclosporine;Mycophenolate Mofetil
3 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant Active, not recruiting NCT00078858 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
4 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
5 Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor Completed NCT00161187 Phase 1
6 Vaccine Trial for Clear Cell Sarcoma, Pediatric Renal Cell Carcinoma, Alveolar Soft Part Sarcoma and Children With Stage IV Melanoma Active, not recruiting NCT00258687 Phase 1
7 MT2004-30: Tomotherapy for Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
8 Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer Active, not recruiting NCT00005799 Not Applicable fludarabine phosphate;cyclosporine;mycophenolate mofetil
9 Studying Tumor Tissue Samples From Patients Who Have Undergone Surgery for Localized Kidney Cancer Withdrawn NCT00908739

Search NIH Clinical Center for Childhood Kidney Cell Carcinoma

Genetic Tests for Childhood Kidney Cell Carcinoma

Anatomical Context for Childhood Kidney Cell Carcinoma

MalaCards organs/tissues related to Childhood Kidney Cell Carcinoma:

42
Kidney, Lung, Liver, Lymph Node, Colon, Heart, Skeletal Muscle

Publications for Childhood Kidney Cell Carcinoma

Articles related to Childhood Kidney Cell Carcinoma:

(show all 23)
# Title Authors Year
1
Treatment of advanced pediatric renal cell carcinoma. ( 31012542 )
2019
2
Nephron-sparing surgery in the treatment of pediatric renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusions. ( 28365106 )
2017
3
Characterization of adolescent and pediatric renal cell carcinoma: A report from the Children's Oncology Group study AREN03B2. ( 25845370 )
2015
4
Biological characteristics of pediatric renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions. ( 24726108 )
2014
5
Persistent complete response after single-agent sunitinib treatment in a case of TFE translocation positive relapsed metastatic pediatric renal cell carcinoma. ( 22995920 )
2013
6
A robotic-assisted laparoscopic approach for pediatric renal cell carcinoma allows for both nephron-sparing surgery and extended lymph node dissection. ( 23084214 )
2012
7
CT and MRI appearances and radiologic staging of pediatric renal cell carcinoma. ( 22249598 )
2012
8
Pediatric Renal Cell Carcinoma. ( 21057600 )
2010
9
Retroperitoneal lymph node dissection for pediatric renal cell carcinoma. ( 19003909 )
2009
10
Pediatric renal cell carcinoma. ( 19443274 )
2009
11
Pediatric renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion. ( 18203790 )
2008
12
Cytologic and cytogenetic diagnosis of pediatric renal cell carcinoma associated with t(X;17). ( 18540314 )
2008
13
Local lymph node involvement in pediatric renal cell carcinoma: a report from the Italian TREP project. ( 18561180 )
2008
14
Pediatric renal cell carcinoma as second malignancy: reports of two cases and a review of the literature. ( 18163925 )
2007
15
Cytogenetic findings in pediatric renal cell carcinoma. ( 17284375 )
2007
16
Pediatric renal cell carcinoma with oncocytoid features occurring in a child after chemotherapy for cardiac leiomyosarcoma. ( 17656235 )
2007
17
Pediatric renal cell carcinoma: clinical, pathologic, and molecular abnormalities associated with the members of the mit transcription factor family. ( 16880148 )
2006
18
Pediatric renal cell carcinoma: single institution 25-year case series and initial experience with partial nephrectomy. ( 16516019 )
2006
19
Pediatric renal-cell carcinoma. ( 15880715 )
2005
20
Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma. ( 15674850 )
2005
21
Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma. ( 15378495 )
2004
22
Partial nephrectomy for pediatric renal cell carcinoma: an unusual case presentation. ( 9123719 )
1997
23
Pediatric renal cell carcinoma: a complete response to recombinant interleukin-2 in a child with metastatic disease at diagnosis. ( 8058009 )
1994

Variations for Childhood Kidney Cell Carcinoma

Cosmic variations for Childhood Kidney Cell Carcinoma:

9 (show top 50) (show all 260)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6941466 XIAP kidney,NS,carcinoma,renal cell carcinoma unclassified c.563G>C p.G188A 23:123886225-123886225 0
2 COSM17872 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.217C>T p.Q73* 3:10142064-10142064 0
3 COSM14425 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.341-2A>T p.? 3:10146512-10146512 0
4 COSM18097 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.482G>A p.R161Q 3:10149805-10149805 0
5 COSM17983 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.500G>A p.R167Q 3:10149823-10149823 0
6 COSM17875 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.234T>G p.N78K 3:10142081-10142081 0
7 COSM25676 VHL kidney,NS,carcinoma,renal cell c.485G>T p.C162F 3:10149808-10149808 0
8 COSM14382 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.245G>C p.R82P 3:10142092-10142092 0
9 COSM14305 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.266T>A p.L89H 3:10142113-10142113 0
10 COSM17957 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.292T>G p.Y98D 3:10142139-10142139 0
11 COSM18350 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.256C>T p.P86S 3:10142103-10142103 0
12 COSM14380 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.548C>A p.S183* 3:10149871-10149871 0
13 COSM14312 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.353T>C p.L118P 3:10146526-10146526 0
14 COSM27269 UMPS kidney,NS,carcinoma,renal cell c.528G>A p.L176L 3:124737785-124737785 0
15 COSM6943738 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.975+1G>T p.? 16:2058874-2058874 0
16 COSM1272079 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.3412C>T p.R1138* 16:2080179-2080179 0
17 COSM7349616 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1717-1G>C p.? 16:2070455-2070455 0
18 COSM6957851 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.541G>A p.V181M 16:2055461-2055461 0
19 COSM7349636 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1189C>T p.Q397* 16:2061940-2061940 0
20 COSM7349639 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.731G>T p.C244F 16:2056726-2056726 0
21 COSM7349621 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.774+1G>A p.? 16:2056770-2056770 0
22 COSM7349321 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1600-1G>T p.? 16:2065518-2065518 0
23 COSM7349619 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.390C>G p.Y130* 16:2054349-2054349 0
24 COSM7349602 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1636G>T p.E546* 16:2065555-2065555 0
25 COSM7349594 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2356-1G>C p.? 16:2074199-2074199 0
26 COSM7349613 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.976-1G>A p.? 16:2060669-2060669 0
27 COSM7349320 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1119+1G>T p.? 16:2060814-2060814 0
28 COSM29770 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.508+1G>T p.? 9:132923347-132923347 0
29 COSM6963117 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1001C>A p.S334* 9:132911481-132911481 0
30 COSM6942356 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2287C>T p.Q763* 9:132902709-132902709 0
31 COSM7349331 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1276G>T p.D426Y 9:132907358-132907358 0
32 COSM7349328 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1835T>A p.L612* 9:132905743-132905743 0
33 COSM30474 TRIO kidney,NS,carcinoma,renal cell c.9008A>G p.N3003S 5:14508136-14508136 0
34 COSM45135 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.673-1G>T p.? 17:7674291-7674291 0
35 COSM6922197 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.97-2A>C p.? 17:7676274-7676274 0
36 COSM44310 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.738G>A p.M246I 17:7674225-7674225 0
37 COSM45243 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.374C>G p.T125R 17:7675995-7675995 0
38 COSM10656 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.742C>T p.R248W 17:7674221-7674221 0
39 COSM10647 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.404G>T p.C135F 17:7675208-7675208 0
40 COSM6929752 TBX3 kidney,NS,carcinoma,renal cell carcinoma unclassified c.510G>T p.W170C 12:114681026-114681026 0
41 COSM6975582 STAG2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1348A>T p.R450* 23:124057909-124057909 0
42 COSM6979493 STAG2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2096+1G>A p.? 23:124065947-124065947 0
43 COSM6023628 STAG2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2860C>T p.R954C 23:124081464-124081464 0
44 COSM6963119 SPOP kidney,NS,carcinoma,renal cell carcinoma unclassified c.265T>G p.L89V 17:49619321-49619321 0
45 COSM989 SMARCB1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1130G>A p.R377H 22:23834152-23834152 0
46 COSM6964939 SMARCB1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.987-2A>T p.? 22:23833570-23833570 0
47 COSM1266238 SMARCA4 kidney,NS,carcinoma,renal cell carcinoma unclassified c.3575G>A p.R1192H 19:11033318-11033318 0
48 COSM4794860 SETD2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.5922+1G>A p.? 3:47019759-47019759 0
49 COSM4118007 SETD2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.3266G>A p.R1089Q 3:47106061-47106061 0
50 COSM6975580 SETD2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.4736C>G p.S1579* 3:47062211-47062211 0

Expression for Childhood Kidney Cell Carcinoma

Search GEO for disease gene expression data for Childhood Kidney Cell Carcinoma.

Pathways for Childhood Kidney Cell Carcinoma

GO Terms for Childhood Kidney Cell Carcinoma

Cellular components related to Childhood Kidney Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.61 ASPSCR1 FOXO1 MITF MLH1 MSH2 PAX3
2 mismatch repair complex GO:0032300 8.62 MLH1 MSH2

Biological processes related to Childhood Kidney Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 FOXO1 MITF PAX2 PAX3 TFE3 TFEB
2 humoral immune response GO:0006959 9.5 MITF TFE3 TFEB
3 somatic hypermutation of immunoglobulin genes GO:0016446 9.46 MLH1 MSH2
4 isotype switching GO:0045190 9.43 MLH1 MSH2
5 positive regulation of transcription, DNA-templated GO:0045893 9.43 FOXO1 MITF PAX2 PAX3 TFE3 TFEB
6 regulation of osteoclast differentiation GO:0045670 9.4 MITF TFE3
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.37 MLH1 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.26 MLH1 MSH2
9 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MLH1 MSH2
10 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MLH1 MSH2

Molecular functions related to Childhood Kidney Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MLH1 MSH2
2 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2
3 protein binding GO:0005515 10.03 ALK ASPSCR1 F3 FOXO1 MITF GPX7

Sources for Childhood Kidney Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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