MCID: CHL061
MIFTS: 51

Childhood Leukemia

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Childhood Leukemia

MalaCards integrated aliases for Childhood Leukemia:

Name: Childhood Leukemia 12 43 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7757
NCIt 50 C4989
UMLS 73 C1332977

Summaries for Childhood Leukemia

MedlinePlus : 43 Leukemia is cancer of the white blood cells. It is the most common type of childhood cancer. Your blood cells form in your bone marrow. White blood cells help your body fight infection. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. Leukemia can develop quickly or slowly. Acute leukemia is a fast growing type while chronic leukemia grows slowly. Children with leukemia usually have one of the acute types. Symptoms include Infections Fever Loss of appetite Tiredness Easy bruising or bleeding Swollen lymph nodes Night sweats Shortness of breath Pain in the bones or joints Risk factors for childhood leukemia include having a brother or sister with leukemia, having certain genetic disorders and having had radiation or chemotherapy. Treatment often cures childhood leukemia. Treatment options include chemotherapy, other drug therapy and radiation. In some cases bone marrow and blood stem cell transplantation might help. NIH: National Cancer Institute

MalaCards based summary : Childhood Leukemia is related to acute lymphoblastic leukemia, childhood and leukemia, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Childhood Leukemia is TCF3 (Transcription Factor 3), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Elliotts B Solution and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and lymph node, and related phenotypes are Reduced mammosphere formation and growth/size/body region

Disease Ontology : 12 A leukemia that occurs in children.

Wikipedia : 76 Childhood leukemia is a type of leukemia, usually acute lymphocytic leukemia (ALL), and a type of... more...

Related Diseases for Childhood Leukemia

Diseases related to Childhood Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 acute lymphoblastic leukemia, childhood 32.4 ETV6 MTHFR RUNX1
2 leukemia 31.2 ABL1 ETV6 MLLT3 PBX1 PTPN11 RUNX1
3 lymphocytic leukemia 30.6 ETV6 KMT2A PTPN11 RUNX1
4 leukemia, acute lymphoblastic 30.5 ABL1 ETV6 KMT2A RUNX1
5 acute lymphocytic leukemia 30.0 ETV6 MTHFR RUNX1
6 acute leukemia 29.6 ETV6 KMT2A MLLT1 MLLT3 MTHFR RUNX1
7 chronic myelomonocytic leukemia 29.5 ETV6 PTPN11 RUNX1
8 myeloid leukemia 29.3 ABL1 ETV6 PTPN11 RUNX1
9 leukemia, acute myeloid 28.8 ABL1 ETV6 KMT2A MLLT1 MLLT3 PTPN11
10 pediatric t-cell leukemia 11.1
11 lymphoma 10.4
12 ring chromosome 21 10.2 ETV6 KMT2A
13 b-cell childhood acute lymphoblastic leukemia 10.2 ETV6 RUNX1
14 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.2 ETV6 KMT2A RUNX1
15 cryptogenic cirrhosis 10.2 HFE MTHFR
16 acute myeloid leukemia with t(9;11)(p22;q23) 10.2 KMT2A MLLT3
17 platelet disorder, familial, with associated myeloid malignancy 10.1 ETV6 RUNX1
18 lymphoid leukemia 10.1 ETV6 KMT2A
19 b-cell adult acute lymphocytic leukemia 10.1 ABL1 PBX1
20 precursor t-cell acute lymphoblastic leukemia 10.0 ABL1 ETV6 KMT2A
21 hematopoietic stem cell transplantation 10.0
22 leukemia, chronic myeloid 9.9 ABL1 ETV6 KMT2A RUNX1
23 osteonecrosis 9.9
24 neonatal leukemia 9.9 MLLT3 PTPN11
25 arthritis 9.9
26 influenza 9.9
27 bone marrow cancer 9.9 ABL1 ETV6 KMT2A PTPN11 RUNX1
28 hematologic cancer 9.9 ABL1 ETV6 KMT2A PTPN11 RUNX1
29 leukemia, acute lymphoblastic 3 9.8 ABL1 ETV6 KMT2A PBX1 RUNX1 TCF3
30 down syndrome 9.8
31 glucocorticoid resistance, generalized 9.8
32 brain cancer 9.8
33 pneumonia 9.8
34 rheumatoid arthritis 9.7
35 hemochromatosis, type 1 9.7
36 lymphoma, hodgkin, classic 9.7
37 lymphoma, non-hodgkin, familial 9.7
38 hepatitis 9.7
39 juvenile rheumatoid arthritis 9.7
40 measles 9.7
41 lymphosarcoma 9.7
42 cytomegalic inclusion disease 9.7
43 cytomegalovirus infection 9.7
44 multiple sclerosis 9.6
45 attention deficit-hyperactivity disorder 9.6
46 myositis 9.6
47 carney complex, type 1 9.6
48 noonan syndrome 1 9.6
49 sturge-weber syndrome 9.6
50 ataxia-telangiectasia 9.6

Graphical network of the top 20 diseases related to Childhood Leukemia:



Diseases related to Childhood Leukemia

Symptoms & Phenotypes for Childhood Leukemia

UMLS symptoms related to Childhood Leukemia:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Childhood Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.28 C1QC ETV6 HFE KMT2A NQO1 PTPN11

MGI Mouse Phenotypes related to Childhood Leukemia:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.41 ABL1 ACTG1 ARID5B CYP1A1 ETV6 HFE
2 hematopoietic system MP:0005397 10.4 ABL1 AKR1C3 ARID5B CYP1A1 ETV6 HFE
3 homeostasis/metabolism MP:0005376 10.36 ABL1 AKR1C3 ARID5B CYP1A1 ETV6 HFE
4 immune system MP:0005387 10.34 ABL1 ARID5B CYP1A1 ETV6 HFE KMT2A
5 cellular MP:0005384 10.32 ABL1 ARID5B ETV6 HFE KMT2A NQO1
6 mortality/aging MP:0010768 10.31 ABL1 ACTG1 ARID5B CYP1A1 EAF2 ETV6
7 cardiovascular system MP:0005385 10.24 ABL1 CYP1A1 EAF2 ETV6 KMT2A PBX1
8 embryo MP:0005380 10.21 ABL1 ETV6 KMT2A MLLT3 PBX1 PTPN11
9 liver/biliary system MP:0005370 10.21 ABL1 CYP1A1 HFE KMT2A MLLT1 MTHFR
10 endocrine/exocrine gland MP:0005379 10.2 ABL1 ARID5B CYP1A1 EAF2 ETV6 PBX1
11 digestive/alimentary MP:0005381 10.17 ABL1 ACTG1 ARID5B ETV6 HFE PBX1
12 integument MP:0010771 10.13 EAF2 ETV6 KMT2A MTHFR NQO1 PBX1
13 neoplasm MP:0002006 10.02 EAF2 ETV6 KMT2A MLLT1 MLLT3 NQO1
14 nervous system MP:0003631 10.02 ABL1 ACTG1 HFE KMT2A MTHFR PBX1
15 limbs/digits/tail MP:0005371 10 ARID5B HFE KMT2A MTHFR PBX1 PTPN11
16 no phenotypic analysis MP:0003012 9.96 CYP1A1 ETV6 HFE KMT2A MLLT3 MTHFR
17 normal MP:0002873 9.9 ABL1 CYP1A1 ETV6 HFE KMT2A MLLT1
18 reproductive system MP:0005389 9.56 AKR1C3 ARID5B EAF2 KMT2A MTHFR PBX1
19 skeleton MP:0005390 9.28 ABL1 ARID5B HFE KMT2A MLLT3 MTHFR

Drugs & Therapeutics for Childhood Leukemia

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Elliotts B Solution 18 CALCIUM CHLORIDE; DEXTROSE; MAGNESIUM SULFATE; POTASSIUM CHLORIDE; SODIUM BICARBONATE; SODIUM CHLORIDE; SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE Orphan Medical October 1996

Drugs for Childhood Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 175)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 1177-87-3
2
Methotrexate Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
3
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 130167-69-0
4
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
5
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 23214-92-8 31703
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 50-02-2 5743
7
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 147-94-4 6253
8
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 57-22-7, 2068-78-2 5978
9
Thioguanine Approved Phase 4,Phase 3,Phase 1 154-42-7 2723601
10
Azathioprine Approved Phase 4 446-86-6 2265
11
Doxil Approved June 1999 Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 31703
12 BB 1101 Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
13
asparaginase Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
15 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
16 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
17 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
18 6-Mercaptopurine Phase 4,Phase 3,Phase 1,Not Applicable
19 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
20 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21
Cladribine Approved, Investigational Phase 2, Phase 3 4291-63-8 20279
22
Idarubicin Approved Phase 2, Phase 3,Not Applicable 58957-92-9 42890
23
Daunorubicin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 20830-81-3 30323
24
leucovorin Approved Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 58-05-9 6006 143
25
Prednisolone Approved, Vet_approved Phase 3,Not Applicable 50-24-8 5755
26
Methylprednisolone Approved, Vet_approved Phase 3,Not Applicable 83-43-2 6741
27
Methylprednisolone hemisuccinate Approved Phase 3,Not Applicable 2921-57-5
28
Prednisolone phosphate Approved, Vet_approved Phase 3,Not Applicable 302-25-0
29
Vinblastine Approved Phase 3 865-21-4 241903 13342
30
Hydrocortisone Approved, Vet_approved Phase 3,Phase 1 50-23-7 5754
31
Ifosfamide Approved Phase 3,Early Phase 1 3778-73-2 3690
32
Etoposide Approved Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
33
Levoleucovorin Approved, Investigational Phase 3,Phase 1 68538-85-2
34
Hydrocortisone acetate Approved, Vet_approved Phase 3,Phase 1 50-03-3
35
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
36 Clove Approved Phase 2, Phase 3
37
Clofarabine Approved, Investigational Phase 2, Phase 3,Phase 1 123318-82-1 119182
38
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 1 22916-47-8 4189
39
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
40
Thiotepa Approved, Investigational Phase 3 52-24-4 5453
41
Zoledronic acid Approved Phase 3 118072-93-8 68740
42
Calcium Carbonate Approved, Investigational Phase 3 471-34-1
43
Chlorambucil Approved Phase 3 305-03-3 2708
44
alemtuzumab Approved, Investigational Phase 3 216503-57-0
45
Dasatinib Approved, Investigational Phase 3,Phase 1 302962-49-8 3062316
46
rituximab Approved Phase 3 174722-31-7 10201696
47
Vindesine Approved, Investigational Phase 3 59917-39-4, 53643-48-4 40839
48
Captopril Approved Phase 3 62571-86-2 44093
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 59-30-3 6037
50
Calcitriol Approved, Nutraceutical Phase 3 32222-06-3 5280453 134070

Interventional clinical trials:

(show top 50) (show all 81)
# Name Status NCT ID Phase Drugs
1 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
2 Thiopurine Induced Pancreatitis in IBD Patients Recruiting NCT02281799 Phase 4 Azathioprine
3 Therapy-Optimization Trial for the Treatment of Acute Myeloid Leukemias (AML) in Children and Adolescents Unknown status NCT00111345 Phase 2, Phase 3 Anthracyclines;liposomal daunorubicin;2-CDA;AI
4 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate
5 Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma Unknown status NCT00006455 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;therapeutic hydrocortisone;vinblastine sulfate
6 Treatment of Acute Lymphoblastic Leukemia in Children Completed NCT00165178 Phase 3 prednisone;dexamethasone;doxorubicin;E. coli asparaginase;vincristine;methotrexate;Leucovorin;Asparaginase;cytarabine;Methotrexate/Hydrocortisone
7 Clove In The Treatment Of Relapsed Or Resistant Acute Leukemia In Children Completed NCT01385891 Phase 2, Phase 3 Clofarabine VP 16 ciclophospahamide
8 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00022737 Phase 3 asparaginase;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;ifosfamide;imatinib mesylate;leucovorin calcium;mercaptopurine tablet;methotrexate;pegaspargase;vincristine sulfate
9 Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00152139 Phase 3 Chemotherapy and antibodies
10 Zometa Study in Pediatric Acute Lymphoblastic Leukemia Completed NCT01656512 Phase 3 zolendronic acid;calcium & vitamin D
11 A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Completed NCT00186901 Phase 3 Calcium carbonate (Tums), vitamin D
12 Efficacy/Safety of Frontline Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Lymphocytic Leukemia Completed NCT00046683 Phase 3 alemtuzumab
13 Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Recruiting NCT03020030 Phase 3 Pegaspargase;Erwinia asparaginase;Cyclophosphamide;CYTARABINE;DASATINIB;DEXAMETHASONE;Dexrazoxane;Doxorubicin;ETOPOSIDE;HYDROCORTISONE;LEUCOVORIN CALCIUM;MERCAPTOPURINE;METHOTREXATE;NELARABINE;Vincristine
14 Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents Recruiting NCT03206671 Phase 3 Rituximab window;Additional doses of Rituximab;Cyclophosphamide;Cytarabine;Dexamethasone;Doxorubicin hydrochloride;Vindesine Sulfate;Etoposide;Ifosfamide;Methotrexate;Prednisolone;Vincristine
15 Prevention of Chemotherapy Induced Cardiotoxicity in Children With Bone Tumors and Acute Myeloid Leukemia Recruiting NCT03389724 Phase 3 Capoten®
16 Treatment of Acute Lymphoblastic Leukemia in Children Active, not recruiting NCT00400946 Phase 3 asparaginase;cyclophosphamide;cytarabine;dexamethasone;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;therapeutic hydrocortisone;vincristine sulfate
17 Safety and Efficacy of Imatinib Added to Chemotherapy in Treatment of Ph+ Acute Lymphoblastic Leukemia in Children Completed NCT00287105 Phase 2 Standard chemotherapy + Imatinib
18 Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL) Completed NCT00440726 Phase 1, Phase 2 bortezomib (Velcade);dexamethasone;PEG-asparaginase;doxorubicin;cytarabine;methotrexate;vincristine
19 Treatment of Newly Diagnosed High Risk Acute Lymphoblastic Leukemia in Children Recruiting NCT02339350 Phase 2 high dose methotrexate;Intrathecal triple chemotherapy
20 NK Cells as Consolidation Therapy of Acute Myeloid Leukemia in Children/Adolescents Recruiting NCT02763475 Phase 2 cyclophosphamide;Fludarabine;IL-2
21 Liposomal Cytarabine in the Treatment of Central Nervous System Resistant or Relapsed Acute Lymphoblastic Leukemia in Children Recruiting NCT01593488 Phase 2 liposomal cytarabine
22 T2007-002 Clofarabine, Etoposide, Cyclophosphamide in Relapsed Acute Myelogenous Leukemia (AML) Terminated NCT00939653 Phase 2 clofarabine;etoposide;cyclophosphamide;filgrastim;cytarabine
23 A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL Terminated NCT01483690 Phase 1, Phase 2 Decitabine;Vorinostat;Vincristine;Dexamethasone;Mitoxantrone;Pegaspargase;Methotrexate
24 Clofarabine With Cytarabine for Patients With Minimal Residual Disease Positive Leukemia Terminated NCT01158885 Phase 2 Clofarabine;Cytarabine;Methotrexate;Cytarabine
25 Trial of Nelarabine, Etoposide and Cyclophosphamide in Relapsed T-cell ALL and T-cell LL Terminated NCT00981799 Phase 1, Phase 2 Nelarabine;Etoposide;Cyclophosphamide;Methotrexate;Filgrastim
26 Clofarabine for Langerhans in Pedi Withdrawn NCT01796405 Phase 2 Clofarabine
27 Study of IRNEA (Irinotecan, Etoposide, Cytarabine) for Refractory or Relapsed Acute Leukemia in Children and Adolescents Unknown status NCT01239485 Phase 1 Irinotecan
28 Clofarabine and Low Dose Total Body Irradiation as a Preparative Regimen for Stem Cell Transplant in Leukemia. Completed NCT01041508 Phase 1 Clofarabine;Cyclosporins;Mycophenolate mofetil
29 Bendamustine Hydrochloride, Clofarabine, and Etoposide in Treating Younger Patients With Relapsed or Refractory Hematologic Malignancies Completed NCT01900509 Phase 1 Bendamustine;Clofarabine;Etoposide;Etoposide phosphate;Dexamethasone
30 A Phase I Study of 5-Azacytidine in Combination With Chemotherapy for Children With Relapsed or Refractory ALL or AML Completed NCT01861002 Phase 1 Azacytidine;Fludarabine;Cytarabine
31 A Phase I Study of AC220 for Children With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia Completed NCT01411267 Phase 1 AC220;Cytarabine;Etoposide;Methotrexate
32 A Study Of Panobinostat In Children With Refractory Hematologic Malignancies Completed NCT01321346 Phase 1 Panobinostat;Cytarabine;Panobinostat
33 Dose Escalation Study of Clofarabine in Patients With Relapsed or Refractory Low Grade or Intermediate-Grade B-Cell Lymphoma Completed NCT00338494 Phase 1 Clofarabine
34 Cytokine Induced Memory-like NK Cell Adoptive Therapy for Relapsed AML After Allogeneic Hematopoietic Cell Transplant Recruiting NCT03068819 Phase 1 CIML NK Cell Infusion
35 PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Recruiting NCT03817320 Phase 1 Ixazomib;Vincristine;Dexamethasone;Asparaginase;Doxorubicin
36 Epigenetic Reprogramming in Relapse/Refractory AML Recruiting NCT03263936 Phase 1 Decitabine;Vorinostat;Filgrastim (G-CSF);Fludarabine;Cytarabine
37 Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults With Relapsed ALL Recruiting NCT02879643 Phase 1 Marqibo in combination with UK ALL R3
38 A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma Recruiting NCT01614197 Phase 1 Temsirolimus;Etoposide;Etoposide;Cyclophosphamide;Methotrexate;Hydrocortisone;Cytarabine
39 Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia Recruiting NCT02303821 Phase 1 Carfilzomib;Dexamethasone;Mitoxantrone;PEG-asparaginase;Vincristine;Intrathecal (IT) Methotrexate;Intrathecal Triple Therapy (Intrathecal Cytarabine, Hydrocortisone, and Methotrexate);6-Mercaptopurine;Cyclophosphamide;Cytarabine;Daunorubicin
40 Monitoring and Treatment of Relapsed Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation in Children Active, not recruiting NCT02484261 Phase 1 Bortezomib;Pravastatin
41 Study of Dasatinib in Children and Adolescents With Relapsed or Refractory Leukemia Active, not recruiting NCT00306202 Phase 1 Dasatinib;Dasatinib;Dasatinib
42 Safety of Fluvastatin-Celebrex Association in Low-grade and High Grade Optico-chiasmatic Gliomas Active, not recruiting NCT02115074 Phase 1 Fluvastatine;Celebrex
43 Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML Active, not recruiting NCT02091245 Phase 1 KPT-330
44 Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224) Terminated NCT00928200 Phase 1 Erwinase;Vincristine;Dexamethasone;Doxorubicin;Cytarabine;Methotrexate;Triple Intrathecal Therapy
45 ABT-751 With Chemotherapy for Relapsed Pediatric ALL Terminated NCT00439296 Phase 1 ABT-751;dexamethasone;PEG-asparaginase;doxorubicin;cytarabine;methotrexate;cyclophosphamide;6-thioguanine
46 Phase I Study of GNKG168 in Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia Terminated NCT01743807 Phase 1 GNKG168
47 Panobinostat With Fludarabine and Cytarabine for Treatment of Children With Acute Myeloid Leukemia or Myelodysplastic Syndrome Terminated NCT02676323 Phase 1 Panobinostat;Fludarabine;Cytarabine;Intrathecal Triples;Leucovorin
48 EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL) Terminated NCT01186328 Phase 1 EZN-3042;Cytarabine;Doxorubicin;Prednisone;Vincristine;Pegaspargase;Methotrexate
49 Prevalence of Psychocognitive Impairments in Adolescents Surviving Childhood Leukemia : LEA-PsyCog Unknown status NCT01741662 Not Applicable
50 The Metabolic Syndrome Among Leukemia Survivors: Physiopathological Analysis Unknown status NCT02696304 Not Applicable

Search NIH Clinical Center for Childhood Leukemia

Genetic Tests for Childhood Leukemia

Anatomical Context for Childhood Leukemia

MalaCards organs/tissues related to Childhood Leukemia:

41
Bone, Bone Marrow, Lymph Node, Brain, Myeloid, B Cells, T Cells

Publications for Childhood Leukemia

Articles related to Childhood Leukemia:

(show top 50) (show all 1011)
# Title Authors Year
1
The association between birth order and childhood leukemia may be modified by paternal age and birth weight. Pooled results from the International Childhood Cancer Cohort Consortium (I4C). ( 30098208 )
2019
2
The Association Between Childhood Leukemia and Population Mixing: An Artifact of Focusing on Clusters? ( 30247205 )
2019
3
Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group. ( 29360413 )
2018
4
A greater birthweight increases the risk of acute leukemias in Mexican children-experience from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia (MIGICCL). ( 29533016 )
2018
5
Long-term sequelae in survivors of childhood leukemia with Down syndrome: A childhood cancer survivor study report. ( 29105081 )
2018
6
dbLGL: an online leukemia gene and literature database for the retrospective comparison of adult and childhood leukemia genetics with literature evidence. ( 29961819 )
2018
7
Ambient benzene at the residence and risk for subtypes of childhood leukemia, lymphoma and CNS tumor. ( 29633247 )
2018
8
Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment. ( 29716390 )
2018
9
Prevalence and characteristics of metabolic syndrome in adults from the French childhood leukemia survivors' cohort: A comparison with controls from the French population. ( 29351982 )
2018
10
Residential mobility and childhood leukemia. ( 29574256 )
2018
11
Maternal residential pesticide use and risk of childhood leukemia in Costa Rica. ( 29658108 )
2018
12
Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study. ( 29728694 )
2018
13
Acid-suppressing Drugs and a Low 1 Level of Antithrombin as Risk Factors for L-Asparaginase-associated Pancreatitis: A Case-control Study in the Japan Association of Childhood Leukemia Study (JACLS). ( 29697579 )
2018
14
Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta-analyses from the Childhood Leukemia International Consortium. ( 29663688 )
2018
15
Re: Kheifets et al. (2017): Residential magnetic fields exposure and childhood leukemia: a population-based case-control study in California. ( 29736896 )
2018
16
Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium. ( 29761423 )
2018
17
SLCO1B1 Polymorphisms are Associated With Drug Intolerance in Childhood Leukemia Maintenance Therapy. ( 29683944 )
2018
18
Family interactions in childhood leukemia: an exploratory descriptive study. ( 29948395 )
2018
19
Radiation exposure from computerised tomography and risk of childhood leukemia: Finnish register-based case-control study of childhood leukemia (FRECCLE). ( 29976736 )
2018
20
Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: a pooled analysis from the childhood Leukemia International Consortium. ( 29600472 )
2018
21
Brain Connectivity and Cognitive Flexibility in Nonirradiated Adult Survivors of Childhood Leukemia. ( 29514304 )
2018
22
A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from TACL consortium. ( 29339403 )
2018
23
Changes in Oxidant Defense, Apoptosis, and Cognitive Abilities During Treatment for Childhood Leukemia. ( 29514461 )
2018
24
Neurocognitive Consequences of Childhood Leukemia and Its Treatment. ( 29398801 )
2018
25
Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment. ( 30054283 )
2018
26
Genetic polymorphisms in candidate genes are not associated with increased vincristine-related peripheral neuropathy in Arab children treated for acute childhood leukemia: a single institution study. ( 30119132 )
2018
27
Protective effect of breastfeeding against childhood leukemia in Zhejiang Province, P. R. China: a retrospective case-control study. ( 30138041 )
2018
28
Putative new childhood leukemia cancer predisposition syndrome caused by germline bi-allelic missense mutations in DDX41. ( 30144193 )
2018
29
Echocardiographic evolution of left ventricular function in childhood leukemia survivors. ( 30166052 )
2018
30
Extracorporeal membrane oxygenation offers long-term survival in childhood leukemia and acute respiratory failure. ( 30241492 )
2018
31
Single-cell mass cytometry and machine learning predict relapse in childhood leukemia. ( 30263942 )
2018
32
Nonclonal Chromosomal Aberrations in Childhood Leukemia Survivors. ( 30273079 )
2018
33
Uncommon Presentation of Childhood Leukemia in Emergency Department: The Usefulness of an Early Multidisciplinary Approach. ( 30461671 )
2018
34
Improving diagnosis and treatment of acute childhood leukemia in Uganda: impact of flow cytometry. ( 30504192 )
2018
35
Somatic Structural Alterations in Childhood Leukemia Can Be Backtracked in Neonatal Dried Blood Spots by Use of Whole-Genome Sequencing and Digital PCR. ( 30518665 )
2018
36
Lower quality of life in young men after pediatric kidney transplantation when compared to healthy controls and survivors of childhood leukemia-a cross-sectional study. ( 28850735 )
2017
37
Gestational age and childhood leukemia: A meta-analysis of epidemiologic studies. ( 29099685 )
2017
38
Feasibility of baseline neurocognitive assessment using Cogstate during the first month of therapy for childhood leukemia. ( 27726029 )
2017
39
Microstructure alterations in the Hypothalamus in cranially radiated Childhood Leukemia survivors but not in Craniopharyngioma patients unaffected by hypothalamic damage. ( 28502079 )
2017
40
Phase I Study of Clofarabine and 2-Gy Total Body Irradiation as a Nonmyeloablative Preparative Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patients with Hematologic Malignancies: A Therapeutic Advances in Childhood Leukemia Consortium Study. ( 28396162 )
2017
41
Infectious Agents in Childhood Leukemia. ( 29157671 )
2017
42
Long-term Results of the Risk-adapted Treatment for Childhood B-Cell Acute Lymphoblastic Leukemia: Report From the Japan Association of Childhood Leukemia Study ALL-97 Trial. ( 28169879 )
2017
43
The Contribution of MMP-8 Promoter Genotypes to Childhood Leukemia. ( 29102926 )
2017
44
Geographical Distribution and Cluster Detection of Childhood Leukemia in the Metropolitan Area of Guadalajara, Mexico. ( 28613286 )
2017
45
Residential magnetic fields exposure and childhood leukemia: a population-based case-control study in California. ( 28900736 )
2017
46
50 Years Ago in The Journal of Pediatrics: Prevention and Management of Acute Hyperuricemia in Childhood Leukemia. ( 29173302 )
2017
47
Trends in childhood leukemia incidence over two decades from 1992 to 2013. ( 27778348 )
2017
48
Space-Time Clustering of Childhood Leukemia: Evidence of an Association with ETV6-RUNX1 (TEL-AML1) Fusion. ( 28129329 )
2017
49
Residential Proximity to Gasoline Stations and Risk of Childhood Leukemia. ( 27923798 )
2017
50
Contribution of Matrix Metalloproteinase-7 Genotypes to the Risk of Non-solid Tumor, Childhood Leukemia. ( 29187444 )
2017

Variations for Childhood Leukemia

Expression for Childhood Leukemia

Search GEO for disease gene expression data for Childhood Leukemia.

Pathways for Childhood Leukemia

Pathways related to Childhood Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 NQO1 PBX1 RUNX1 TCF3
2 11.44 ETV6 KMT2A MLLT1 MLLT3 PBX1 RUNX1

GO Terms for Childhood Leukemia

Cellular components related to Childhood Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 ABL1 ARID5B EAF2 KMT2A MLLT1 MLLT3
2 HFE-transferrin receptor complex GO:1990712 9.16 HFE TFRC
3 transcription elongation factor complex GO:0008023 8.8 EAF2 MLLT1 MLLT3
4 nucleus GO:0005634 10.1 ABL1 ACTG1 AKR1C3 ARID5B EAF2 ETV6

Biological processes related to Childhood Leukemia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 EAF2 KMT2A MLLT3 RUNX1 TCF3
2 transcription by RNA polymerase II GO:0006366 9.7 EAF2 ETV6 KMT2A MLLT1 MLLT3 PBX1
3 regulation of transcription, DNA-templated GO:0006355 9.65 ABL1 ARID5B EAF2 ETV6 KMT2A MLLT1
4 transcription elongation from RNA polymerase II promoter GO:0006368 9.58 EAF2 MLLT1 MLLT3
5 adrenal gland development GO:0030325 9.49 ARID5B PBX1
6 embryonic hemopoiesis GO:0035162 9.46 KMT2A PBX1
7 hematopoietic stem cell proliferation GO:0071425 9.43 ETV6 RUNX1
8 platelet-derived growth factor receptor signaling pathway GO:0048008 9.43 ABL1 ARID5B PTPN11
9 Bergmann glial cell differentiation GO:0060020 9.37 ABL1 PTPN11
10 positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 9.32 ABL1 MLLT3
11 regulation of hematopoietic stem cell differentiation GO:1902036 8.92 ABL1 KMT2A RUNX1 TCF3

Molecular functions related to Childhood Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.91 ABL1 ARID5B ETV6 KMT2A MLLT1 PBX1
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.76 ARID5B ETV6 KMT2A MLLT1 MLLT3 PBX1
3 protein binding GO:0005515 9.58 ABL1 ACTG1 ARID5B C1QC CYP1A1 EAF2
4 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.35 ARID5B EAF2 ETV6 PBX1 RUNX1
5 lysine-acetylated histone binding GO:0070577 9.32 KMT2A MLLT3

Sources for Childhood Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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