Childhood Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Childhood Leukemia

MalaCards integrated aliases for Childhood Leukemia:

Name: Childhood Leukemia 12 44 15 74


External Ids:

Disease Ontology 12 DOID:7757
NCIt 51 C4989
UMLS 74 C1332977

Summaries for Childhood Leukemia

MedlinePlus : 44 Leukemia is cancer of the white blood cells. It is the most common type of childhood cancer. Your blood cells form in your bone marrow. White blood cells help your body fight infection. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. Leukemia can develop quickly or slowly. Acute leukemia is a fast growing type while chronic leukemia grows slowly. Children with leukemia usually have one of the acute types. Symptoms include Infections Fever Loss of appetite Tiredness Easy bruising or bleeding Swollen lymph nodes Night sweats Shortness of breath Pain in the bones or joints Risk factors for childhood leukemia include having a brother or sister with leukemia, having certain genetic disorders and having had radiation or chemotherapy. Treatment often cures childhood leukemia. Treatment options include chemotherapy, other drug therapy and radiation. In some cases bone marrow and blood stem cell transplantation might help. NIH: National Cancer Institute

MalaCards based summary : Childhood Leukemia is related to acute lymphoblastic leukemia, childhood and leukemia, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Childhood Leukemia is TCF3 (Transcription Factor 3), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Dexamethasone acetate and Pegaspargase have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are Reduced mammosphere formation and growth/size/body region

Disease Ontology : 12 A leukemia that occurs in children.

Wikipedia : 77 Childhood leukemia is leukemia that occurs in a child and is a type of childhood cancer. Childhood... more...

Related Diseases for Childhood Leukemia

Diseases related to Childhood Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 acute lymphoblastic leukemia, childhood 32.6 ETV6 MTHFR RUNX1
2 leukemia 31.0 ABL1 ETV6 MLLT3 PBX1 PTPN11 RUNX1
3 lymphocytic leukemia 30.7 ETV6 KMT2A PTPN11 RUNX1
4 acute lymphocytic leukemia 30.5 ETV6 MTHFR RUNX1 TYMS
5 leukemia, acute lymphoblastic 30.4 ABL1 ETV6 KMT2A RUNX1
6 acute leukemia 29.5 ETV6 KMT2A MLLT1 MLLT3 MTHFR RUNX1
7 myeloid leukemia 29.4 ABL1 ETV6 PTPN11 RUNX1
8 leukemia, acute myeloid 28.6 ABL1 ETV6 KMT2A MLLT1 MLLT3 PTPN11
9 myelodysplastic syndrome 28.5 ABL1 ETV6 HFE KMT2A NQO1 PTPN11
10 childhood acute myeloid leukemia 11.3
11 pediatric t-cell leukemia 11.1
12 lymphoma 10.4
13 ring chromosome 21 10.4 ETV6 KMT2A
14 b-cell childhood acute lymphoblastic leukemia 10.4 ETV6 RUNX1
15 hemifacial spasm 10.3 MTHFR TYMS
16 cryptogenic cirrhosis 10.3 HFE MTHFR
17 acute myeloid leukemia with t(9;11)(p22;q23) 10.3 KMT2A MLLT3
18 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.3 ETV6 KMT2A RUNX1
19 platelet disorder, familial, with associated myeloid malignancy 10.3 ETV6 RUNX1
20 lymphoid leukemia 10.2 ETV6 KMT2A
21 chronic myelomonocytic leukemia 10.1 ETV6 PTPN11 RUNX1
22 b-cell adult acute lymphocytic leukemia 10.0 ABL1 PBX1
23 neonatal leukemia 10.0 MLLT3 PTPN11
24 hematopoietic stem cell transplantation 10.0
25 osteonecrosis 10.0
26 influenza 10.0
27 precursor t-cell acute lymphoblastic leukemia 9.9 ABL1 ETV6 KMT2A
28 sclerosing cholangitis, neonatal 9.9
29 arthritis 9.9
30 leukemia, chronic myeloid 9.9 ABL1 ETV6 KMT2A RUNX1
31 down syndrome 9.8
32 acute insulin response 9.8
33 glucocorticoid resistance, generalized 9.8
34 hepatitis 9.8
35 brain cancer 9.8
36 pneumonia 9.8
37 rheumatoid arthritis 9.8
38 hemochromatosis, type 1 9.8
39 lymphoma, hodgkin, classic 9.8
40 lymphoma, non-hodgkin, familial 9.8
41 meningioma, familial 9.8
42 spinal meningioma 9.8
43 hyperuricemia 9.8
44 secretory meningioma 9.8
45 juvenile rheumatoid arthritis 9.8
46 measles 9.8
47 juvenile hereditary hemochromatosis 9.8
48 cytomegalic inclusion disease 9.8
49 cytomegalovirus infection 9.8
50 myelodysplastic myeloproliferative cancer 9.7 ABL1 PTPN11

Graphical network of the top 20 diseases related to Childhood Leukemia:

Diseases related to Childhood Leukemia

Symptoms & Phenotypes for Childhood Leukemia

UMLS symptoms related to Childhood Leukemia:

angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Childhood Leukemia according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.28 C1QC ETV6 HFE KMT2A NQO1 PTPN11

MGI Mouse Phenotypes related to Childhood Leukemia:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.36 ABL1 ACTG1 ARID5B CYP1A1 ETV6 HFE
2 hematopoietic system MP:0005397 10.27 ABL1 ARID5B CYP1A1 ETV6 HFE KMT2A
3 cellular MP:0005384 10.26 ABL1 ARID5B ETV6 HFE KMT2A NQO1
4 homeostasis/metabolism MP:0005376 10.26 ABL1 ARID5B CYP1A1 ETV6 HFE KMT2A
5 immune system MP:0005387 10.23 ABL1 ARID5B CYP1A1 ETV6 HFE KMT2A
6 mortality/aging MP:0010768 10.2 ABL1 ACTG1 ARID5B CYP1A1 EAF2 ETV6
7 endocrine/exocrine gland MP:0005379 10.18 ABL1 ARID5B CYP1A1 EAF2 ETV6 PBX1
8 embryo MP:0005380 10.14 ABL1 ETV6 KMT2A MLLT3 PBX1 PTPN11
9 digestive/alimentary MP:0005381 10.09 ABL1 ACTG1 ARID5B ETV6 HFE PBX1
10 liver/biliary system MP:0005370 10.07 ABL1 CYP1A1 HFE KMT2A MLLT1 MTHFR
11 integument MP:0010771 10.03 EAF2 ETV6 KMT2A MTHFR NQO1 PBX1
12 limbs/digits/tail MP:0005371 9.95 ARID5B HFE KMT2A MTHFR PBX1 PTPN11
13 neoplasm MP:0002006 9.91 EAF2 ETV6 KMT2A MLLT1 MLLT3 NQO1
14 no phenotypic analysis MP:0003012 9.81 CYP1A1 ETV6 HFE KMT2A MLLT3 MTHFR
15 normal MP:0002873 9.65 ABL1 CYP1A1 ETV6 HFE KMT2A MLLT1
16 skeleton MP:0005390 9.28 ABL1 ARID5B HFE KMT2A MLLT3 MTHFR

Drugs & Therapeutics for Childhood Leukemia

Drugs for Childhood Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 176)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 1177-87-3
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 130167-69-0
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 2068-78-2, 57-22-7 5978
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4, 65-46-3 6253
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 50-02-2 5743
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 23214-92-8 31703
Methotrexate Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
Mercaptopurine Approved Phase 4,Phase 3,Phase 1,Not Applicable 50-44-2 667490
Thioguanine Approved Phase 4,Phase 3,Phase 1 154-42-7 2723601
Doxil Approved June 1999 Phase 4,Phase 3,Phase 1,Phase 2 31703
12 BB 1101 Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
asparaginase Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
15 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
16 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
17 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
Daunorubicin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 20830-81-3 30323
Cladribine Approved, Investigational Phase 2, Phase 3 4291-63-8 20279
Idarubicin Approved Phase 2, Phase 3,Not Applicable 58957-92-9 42890
Prednisolone Approved, Vet_approved Phase 3,Not Applicable 50-24-8 5755
Prednisolone phosphate Approved, Vet_approved Phase 3,Not Applicable 302-25-0
Methylprednisolone Approved, Vet_approved Phase 3,Not Applicable 83-43-2 6741
Methylprednisolone hemisuccinate Approved Phase 3,Not Applicable 2921-57-5
leucovorin Approved Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 58-05-9 143 6006
Hydrocortisone acetate Approved, Vet_approved Phase 3,Phase 1 50-03-3
Hydrocortisone Approved, Vet_approved Phase 3,Phase 1 50-23-7 5754
Vinblastine Approved Phase 3 865-21-4 241903 13342
Levoleucovorin Approved, Investigational Phase 3,Phase 1 68538-85-2
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
Ifosfamide Approved Phase 3 3778-73-2 3690
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
35 Clove Approved Phase 2, Phase 3
Clofarabine Approved, Investigational Phase 2, Phase 3,Phase 1 123318-82-1 119182
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 1 22916-47-8 4189
Thiotepa Approved, Investigational Phase 3 52-24-4 5453
Zoledronic Acid Approved Phase 3 118072-93-8 68740
Calcium Carbonate Approved, Investigational Phase 3 471-34-1
alemtuzumab Approved, Investigational Phase 3 216503-57-0
Chlorambucil Approved Phase 3 305-03-3 2708
Dasatinib Approved, Investigational Phase 3,Phase 1 302962-49-8 3062316
Vindesine Approved, Investigational Phase 3 53643-48-4, 59917-39-4 40839
rituximab Approved Phase 3 174722-31-7 10201696
Captopril Approved Phase 3 62571-86-2 44093
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 59-30-3 6037
Calcium Approved, Nutraceutical Phase 3,Phase 1 7440-70-2 271
Calcitriol Approved, Nutraceutical Phase 3 32222-06-3 5280453 134070

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
2 Thiopurine Induced Pancreatitis in IBD Patients Withdrawn NCT02281799 Phase 4 Azathioprine
3 Therapy-Optimization Trial for the Treatment of Acute Myeloid Leukemias (AML) in Children and Adolescents Unknown status NCT00111345 Phase 2, Phase 3 Anthracyclines;liposomal daunorubicin;2-CDA;AI
4 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate
5 Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma Unknown status NCT00006455 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;therapeutic hydrocortisone;vinblastine sulfate
6 Treatment of Acute Lymphoblastic Leukemia in Children Completed NCT00165178 Phase 3 prednisone;dexamethasone;doxorubicin;E. coli asparaginase;vincristine;methotrexate;Leucovorin;Asparaginase;cytarabine;Methotrexate/Hydrocortisone
7 Clove In The Treatment Of Relapsed Or Resistant Acute Leukemia In Children Completed NCT01385891 Phase 2, Phase 3 Clofarabine VP 16 ciclophospahamide
8 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00022737 Phase 3 asparaginase;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;ifosfamide;imatinib mesylate;leucovorin calcium;mercaptopurine tablet;methotrexate;pegaspargase;vincristine sulfate
9 Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00152139 Phase 3 Chemotherapy and antibodies
10 Zometa Study in Pediatric Acute Lymphoblastic Leukemia Completed NCT01656512 Phase 3 zolendronic acid;calcium & vitamin D
11 A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Completed NCT00186901 Phase 3 Calcium carbonate (Tums), vitamin D
12 Efficacy/Safety of Frontline Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Lymphocytic Leukemia Completed NCT00046683 Phase 3 alemtuzumab
13 Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Recruiting NCT03020030 Phase 3 Pegaspargase;Erwinia asparaginase;Cyclophosphamide;CYTARABINE;DASATINIB;DEXAMETHASONE;Dexrazoxane;Doxorubicin;ETOPOSIDE;HYDROCORTISONE;LEUCOVORIN CALCIUM;MERCAPTOPURINE;METHOTREXATE;NELARABINE;Vincristine
14 Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents Recruiting NCT03206671 Phase 3 Rituximab window;Additional doses of Rituximab;Cyclophosphamide;Cytarabine;Dexamethasone;Doxorubicin hydrochloride;Vindesine Sulfate;Etoposide;Ifosfamide;Methotrexate;Prednisolone;Vincristine
15 Prevention of Chemotherapy Induced Cardiotoxicity in Children With Bone Tumors and Acute Myeloid Leukemia Recruiting NCT03389724 Phase 3 Capoten®
16 Treatment of Acute Lymphoblastic Leukemia in Children Active, not recruiting NCT00400946 Phase 3 asparaginase;cyclophosphamide;cytarabine;dexamethasone;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;therapeutic hydrocortisone;vincristine sulfate
17 Liposomal Cytarabine in the Treatment of Central Nervous System Resistant or Relapsed Acute Lymphoblastic Leukemia in Children Unknown status NCT01593488 Phase 2 liposomal cytarabine
18 Safety and Efficacy of Imatinib Added to Chemotherapy in Treatment of Ph+ Acute Lymphoblastic Leukemia in Children Completed NCT00287105 Phase 2 Standard chemotherapy + Imatinib
19 Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL) Completed NCT00440726 Phase 1, Phase 2 bortezomib (Velcade);dexamethasone;PEG-asparaginase;doxorubicin;cytarabine;methotrexate;vincristine
20 Treatment of Newly Diagnosed High Risk Acute Lymphoblastic Leukemia in Children Recruiting NCT02339350 Phase 2 high dose methotrexate;Intrathecal triple chemotherapy
21 NK Cells as Consolidation Therapy of Acute Myeloid Leukemia in Children/Adolescents Recruiting NCT02763475 Phase 2 cyclophosphamide;Fludarabine;IL-2
22 Nivolumab in Combination With 5-azacytidine in Childhood Relapsed/Refractory AML Recruiting NCT03825367 Phase 1, Phase 2 Nivolumab;5-azacytidine
23 T2007-002 Clofarabine, Etoposide, Cyclophosphamide in Relapsed Acute Myelogenous Leukemia (AML) Terminated NCT00939653 Phase 2 clofarabine;etoposide;cyclophosphamide;filgrastim;cytarabine
24 A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL Terminated NCT01483690 Phase 1, Phase 2 Decitabine;Vorinostat;Vincristine;Dexamethasone;Mitoxantrone;Pegaspargase;Methotrexate
25 Clofarabine With Cytarabine for Patients With Minimal Residual Disease Positive Leukemia Terminated NCT01158885 Phase 2 Clofarabine;Cytarabine;Methotrexate;Cytarabine
26 Trial of Nelarabine, Etoposide and Cyclophosphamide in Relapsed T-cell ALL and T-cell LL Terminated NCT00981799 Phase 1, Phase 2 Nelarabine;Etoposide;Cyclophosphamide;Methotrexate;Filgrastim
27 Clofarabine for Langerhans in Pedi Withdrawn NCT01796405 Phase 2 Clofarabine
28 Study of IRNEA (Irinotecan, Etoposide, Cytarabine) for Refractory or Relapsed Acute Leukemia in Children and Adolescents Unknown status NCT01239485 Phase 1 Irinotecan
29 Clofarabine and Low Dose Total Body Irradiation as a Preparative Regimen for Stem Cell Transplant in Leukemia. Completed NCT01041508 Phase 1 Clofarabine;Cyclosporins;Mycophenolate mofetil
30 Bendamustine Hydrochloride, Clofarabine, and Etoposide in Treating Younger Patients With Relapsed or Refractory Hematologic Malignancies Completed NCT01900509 Phase 1 Bendamustine;Clofarabine;Etoposide;Etoposide phosphate;Dexamethasone
31 A Phase I Study of 5-Azacytidine in Combination With Chemotherapy for Children With Relapsed or Refractory ALL or AML Completed NCT01861002 Phase 1 Azacytidine;Fludarabine;Cytarabine
32 A Phase I Study of AC220 for Children With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia Completed NCT01411267 Phase 1 AC220;Cytarabine;Etoposide;Methotrexate
33 A Study Of Panobinostat In Children With Refractory Hematologic Malignancies Completed NCT01321346 Phase 1 Panobinostat;Cytarabine;Panobinostat
34 Dose Escalation Study of Clofarabine in Patients With Relapsed or Refractory Low Grade or Intermediate-Grade B-Cell Lymphoma Completed NCT00338494 Phase 1 Clofarabine
35 Cytokine Induced Memory-like NK Cell Adoptive Therapy for Relapsed AML After Allogeneic Hematopoietic Cell Transplant Recruiting NCT03068819 Phase 1 CIML NK Cell Infusion
36 PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Recruiting NCT03817320 Phase 1 Ixazomib;Vincristine;Dexamethasone;Asparaginase;Doxorubicin
37 Epigenetic Reprogramming in Relapse/Refractory AML Recruiting NCT03263936 Phase 1 Decitabine;Vorinostat;Filgrastim (G-CSF);Fludarabine;Cytarabine
38 Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults With Relapsed ALL Recruiting NCT02879643 Phase 1 Marqibo
39 A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma Recruiting NCT01614197 Phase 1 Temsirolimus;Etoposide;Etoposide;Cyclophosphamide;Methotrexate;Hydrocortisone;Cytarabine
40 Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia Recruiting NCT02303821 Phase 1 Carfilzomib;Dexamethasone;Mitoxantrone;PEG-asparaginase;Vincristine;Intrathecal (IT) Methotrexate;Intrathecal Triple Therapy (Intrathecal Cytarabine, Hydrocortisone, and Methotrexate);6-Mercaptopurine;Cyclophosphamide;Cytarabine;Daunorubicin
41 Monitoring and Treatment of Relapsed Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation in Children Active, not recruiting NCT02484261 Phase 1 Bortezomib;Pravastatin
42 Study of Dasatinib in Children and Adolescents With Relapsed or Refractory Leukemia Active, not recruiting NCT00306202 Phase 1 Dasatinib;Dasatinib;Dasatinib
43 Safety of Fluvastatin-Celebrex Association in Low-grade and High Grade Optico-chiasmatic Gliomas Active, not recruiting NCT02115074 Phase 1 Fluvastatine;Celebrex
44 Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML Active, not recruiting NCT02091245 Phase 1 KPT-330
45 ABT-751 With Chemotherapy for Relapsed Pediatric ALL Terminated NCT00439296 Phase 1 ABT-751;dexamethasone;PEG-asparaginase;doxorubicin;cytarabine;methotrexate;cyclophosphamide;6-thioguanine
46 Phase I Study of GNKG168 in Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia Terminated NCT01743807 Phase 1 GNKG168
47 Panobinostat With Fludarabine and Cytarabine for Treatment of Children With Acute Myeloid Leukemia or Myelodysplastic Syndrome Terminated NCT02676323 Phase 1 Panobinostat;Fludarabine;Cytarabine;Intrathecal Triples;Leucovorin
48 EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL) Terminated NCT01186328 Phase 1 EZN-3042;Cytarabine;Doxorubicin;Prednisone;Vincristine;Pegaspargase;Methotrexate
49 Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224) Terminated NCT00928200 Phase 1 Erwinase;Vincristine;Dexamethasone;Doxorubicin;Cytarabine;Methotrexate;Triple Intrathecal Therapy;Dexrazoxane
50 Prevalence of Psychocognitive Impairments in Adolescents Surviving Childhood Leukemia : LEA-PsyCog Unknown status NCT01741662 Not Applicable

Search NIH Clinical Center for Childhood Leukemia

Genetic Tests for Childhood Leukemia

Anatomical Context for Childhood Leukemia

MalaCards organs/tissues related to Childhood Leukemia:

Myeloid, Bone, Bone Marrow, B Cells, Lymph Node, Brain, T Cells

Publications for Childhood Leukemia

Articles related to Childhood Leukemia:

(show top 50) (show all 1106)
# Title Authors Year
High rates of ovarian function preservation after hematopoietic cell transplantation with melphalan-based reduced intensity conditioning for pediatric acute leukemia: an analysis from the Japan Association of Childhood Leukemia Study (JACLS). ( 30864117 )
Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium. ( 30776582 )
The association between birth order and childhood leukemia may be modified by paternal age and birth weight. Pooled results from the International Childhood Cancer Cohort Consortium (I4C). ( 30098208 )
The Association Between Childhood Leukemia and Population Mixing: An Artifact of Focusing on Clusters? ( 30247205 )
Somatic Structural Alterations in Childhood Leukemia Can Be Backtracked in Neonatal Dried Blood Spots by Use of Whole-Genome Sequencing and Digital PCR. ( 30518665 )
Fluctuations in dietary intake during treatment for childhood leukemia: A report from the DALLT cohort. ( 30639117 )
Silencing the PIK3CA Gene Enhances the Sensitivity of Childhood Leukemia Cells to Chemotherapy Drugs by Suppressing the Phosphorylation of Akt. ( 30666840 )
School performance in childhood leukemia survivors. ( 30684977 )
Childhood leukemia risk in the California Power Line Study: Magnetic fields versus distance from power lines. ( 30743245 )
Microstructural white matter alterations associated to neurocognitive deficits in childhood leukemia survivors treated with cranial radiotherapy - a diffusional kurtosis study. ( 30747019 )
Long-term risk of hospitalization among five-year survivors of childhood leukemia in the Nordic countries. ( 30753563 )
Childhood leukemia, late effects, and a person-centric model of follow-up. ( 30753660 )
Predictors of residential mobility and its impact on air pollution exposure among children diagnosed with early childhood leukemia. ( 30770842 )
Association of Matrix Metallopeptidase-2 Promoter Polymorphisms With the Risk of Childhood Leukemia. ( 30842148 )
Meningioma Screening With MRI in Childhood Leukemia Survivors Treated With Cranial Radiation. ( 30880270 )
The impact of severe late-effects after 12 Gy fractionated total body irradiation and allogeneic stem cell transplantation for childhood leukemia (1988-2010). ( 30978121 )
Infant milk-feeding practices and childhood leukemia: a systematic review. ( 30982871 )
Re: The association between childhood leukemia and population mixing: . ( 30985535 )
Association between Outdoor Air Pollution and Childhood Leukemia: A Systematic Review and Dose-Response Meta-Analysis. ( 31017485 )
A Meta-analysis of Traffic-related Air Pollution and Risk of Childhood Leukemia. ( 31026249 )
Parental Occupational Exposure to Pesticides, Animals, and Organic Dust and Risk of Childhood Leukemia and Central Nervous System Tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C). ( 31054169 )
Reduced brain microstructural asymmetry in patients with childhood leukemia treated with chemotherapy compared with healthy controls. ( 31071157 )
Disparities in Survival and Health Outcomes in Childhood Leukemia. ( 31073772 )
Maternal residential pesticide use and risk of childhood leukemia in Costa Rica. ( 29658108 )
Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta-analyses from the Childhood Leukemia International Consortium. ( 29663688 )
SLCO1B1 Polymorphisms are Associated With Drug Intolerance in Childhood Leukemia Maintenance Therapy. ( 29683944 )
Acid-suppressing Drugs and a Low 1 Level of Antithrombin as Risk Factors for L-Asparaginase-associated Pancreatitis: A Case-control Study in the Japan Association of Childhood Leukemia Study (JACLS). ( 29697579 )
Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment. ( 29716390 )
Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study. ( 29728694 )
Re: Kheifets et al. (2017): Residential magnetic fields exposure and childhood leukemia: a population-based case-control study in California. ( 29736896 )
Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium. ( 29761423 )
Family interactions in childhood leukemia: an exploratory descriptive study. ( 29948395 )
dbLGL: an online leukemia gene and literature database for the retrospective comparison of adult and childhood leukemia genetics with literature evidence. ( 29961819 )
Radiation exposure from computerized tomography and risk of childhood leukemia: Finnish register-based case-control study of childhood leukemia (FRECCLE). ( 29976736 )
Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment. ( 30054283 )
Genetic polymorphisms in candidate genes are not associated with increased vincristine-related peripheral neuropathy in Arab children treated for acute childhood leukemia: a single institution study. ( 30119132 )
Protective effect of breastfeeding against childhood leukemia in Zhejiang Province, P. R. China: a retrospective case-control study. ( 30138041 )
Putative new childhood leukemia cancer predisposition syndrome caused by germline bi-allelic missense mutations in DDX41. ( 30144193 )
Echocardiographic evolution of left ventricular function in childhood leukemia survivors. ( 30166052 )
Extracorporeal membrane oxygenation offers long-term survival in childhood leukemia and acute respiratory failure. ( 30241492 )
Single-cell mass cytometry and machine learning predict relapse in childhood leukemia. ( 30263942 )
Nonclonal Chromosomal Aberrations in Childhood Leukemia Survivors. ( 30273079 )
Uncommon Presentation of Childhood Leukemia in Emergency Department: The Usefulness of an Early Multidisciplinary Approach. ( 30461671 )
Improving diagnosis and treatment of acute childhood leukemia in Uganda: impact of flow cytometry. ( 30504192 )
Lower quality of life in young men after pediatric kidney transplantation when compared to healthy controls and survivors of childhood leukemia-a cross-sectional study. ( 28850735 )
Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures. ( 29017430 )
Gestational age and childhood leukemia: A meta-analysis of epidemiologic studies. ( 29099685 )
Long-term sequelae in survivors of childhood leukemia with Down syndrome: A childhood cancer survivor study report. ( 29105081 )
Clinical Presentation, Prognostic Factors, and Outcome in Neutropenic Enteropathy of Childhood Leukemia. ( 29293190 )
A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium. ( 29339403 )

Variations for Childhood Leukemia

Expression for Childhood Leukemia

Search GEO for disease gene expression data for Childhood Leukemia.

Pathways for Childhood Leukemia

Pathways related to Childhood Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 NQO1 PBX1 RUNX1 TCF3

GO Terms for Childhood Leukemia

Cellular components related to Childhood Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 ABL1 ARID5B EAF2 KMT2A MLLT1 MLLT3
2 transcription elongation factor complex GO:0008023 8.8 EAF2 MLLT1 MLLT3
3 nucleus GO:0005634 10 ABL1 ACTG1 ARID5B EAF2 ETV6 KMT2A

Biological processes related to Childhood Leukemia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.93 EAF2 KMT2A MLLT3 RUNX1 TCF3
2 response to organic cyclic compound GO:0014070 9.74 CYP1A1 NQO1 TYMS
3 response to toxic substance GO:0009636 9.69 CYP1A1 NQO1 TYMS
4 regulation of transcription, DNA-templated GO:0006355 9.65 ABL1 ARID5B EAF2 ETV6 KMT2A MLLT1
5 transcription elongation from RNA polymerase II promoter GO:0006368 9.61 EAF2 MLLT1 MLLT3
6 adrenal gland development GO:0030325 9.56 ARID5B PBX1
7 response to vitamin A GO:0033189 9.55 CYP1A1 TYMS
8 embryonic hemopoiesis GO:0035162 9.52 KMT2A PBX1
9 hematopoietic stem cell proliferation GO:0071425 9.49 ETV6 RUNX1
10 tetrahydrofolate interconversion GO:0035999 9.48 MTHFR TYMS
11 tetrahydrofolate metabolic process GO:0046653 9.46 MTHFR TYMS
12 transcription by RNA polymerase II GO:0006366 9.46 EAF2 KMT2A MLLT1 MLLT3
13 platelet-derived growth factor receptor signaling pathway GO:0048008 9.43 ABL1 ARID5B PTPN11
14 Bergmann glial cell differentiation GO:0060020 9.4 ABL1 PTPN11
15 positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 9.37 ABL1 MLLT3
16 response to folic acid GO:0051593 9.32 MTHFR TYMS
17 regulation of hematopoietic stem cell differentiation GO:1902036 8.92 ABL1 KMT2A RUNX1 TCF3
18 positive regulation of transcription by RNA polymerase II GO:0045944 10.05 EAF2 ETV6 KMT2A PBX1 RUNX1 TCF3

Molecular functions related to Childhood Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.91 ABL1 ARID5B ETV6 KMT2A MLLT1 PBX1
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.56 ARID5B ETV6 KMT2A MLLT1 MLLT3 PBX1
3 lysine-acetylated histone binding GO:0070577 9.32 KMT2A MLLT3
4 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.02 ARID5B EAF2 ETV6 PBX1 RUNX1
5 protein binding GO:0005515 10.09 ABL1 ACTG1 ARID5B C1QC CYP1A1 EAF2

Sources for Childhood Leukemia

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
33 HPO
34 ICD10
35 ICD10 via Orphanet
39 LifeMap
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
56 Novoseek
59 OMIM via Orphanet
63 PubMed
71 SNOMED-CT via Orphanet
73 Tocris
75 UMLS via Orphanet
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