MCID: CHL151
MIFTS: 24

Childhood Non-Hodgkin Lymphoma

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Childhood Non-Hodgkin Lymphoma

MalaCards integrated aliases for Childhood Non-Hodgkin Lymphoma:

Name: Childhood Non-Hodgkin Lymphoma 53
Pediatric Non-Hodgkin Lymphoma 53

Classifications:



Summaries for Childhood Non-Hodgkin Lymphoma

MalaCards based summary : Childhood Non-Hodgkin Lymphoma, also known as pediatric non-hodgkin lymphoma, is related to lymphoma, non-hodgkin, familial and lymphoma, hodgkin, classic. An important gene associated with Childhood Non-Hodgkin Lymphoma is ATM (ATM Serine/Threonine Kinase), and among its related pathways/superpathways is Immune response IFN alpha/beta signaling pathway. The drugs Miconazole and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and endothelial, and related phenotypes are Reduced mammosphere formation and neoplasm

Related Diseases for Childhood Non-Hodgkin Lymphoma

Diseases related to Childhood Non-Hodgkin Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 lymphoma, non-hodgkin, familial 10.7
2 lymphoma, hodgkin, classic 10.7
3 lymphoma 10.6
4 lymphoblastic lymphoma 10.5
5 burkitt lymphoma 10.3
6 b-cell lymphoma 10.3
7 anaplastic large cell lymphoma 10.2
8 b-cell non-hodgkin lymphoma 10.2
9 kearns-sayre syndrome 10.0
10 leukemia, acute myeloid 10.0
11 yemenite deaf-blind hypopigmentation syndrome 10.0
12 leukemia, acute lymphoblastic 10.0
13 leukemia, acute lymphoblastic 3 10.0
14 diffuse large b-cell lymphoma 10.0
15 ptosis 10.0
16 mucositis 10.0
17 lymphocytic leukemia 10.0
18 thrombocytopenia 10.0
19 histoplasmosis 10.0
20 paraplegia 10.0
21 exophthalmos 10.0
22 headache 10.0
23 t-cell non-hodgkin lymphoma 10.0
24 nasopharyngeal carcinoma 10.0
25 marginal zone b-cell lymphoma 10.0
26 peripheral t-cell lymphoma 10.0
27 follicular lymphoma 10.0
28 cutaneous t cell lymphoma 10.0
29 childhood acute lymphocytic leukemia 10.0
30 nodal marginal zone lymphoma 10.0
31 castleman disease 10.0
32 autonomic neuropathy 10.0
33 leukemia 10.0
34 leiomyoma 10.0
35 guillain-barre syndrome 10.0
36 obstructive jaundice 10.0
37 panniculitis 10.0
38 leiomyosarcoma 10.0
39 nervous system cancer 10.0
40 central nervous system lymphoma 10.0
41 central nervous system cancer 10.0
42 adult lymphoma 10.0
43 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.0
44 neuropathy 10.0
45 lymphosarcoma 10.0
46 primary central nervous system lymphoma 10.0

Graphical network of the top 20 diseases related to Childhood Non-Hodgkin Lymphoma:



Diseases related to Childhood Non-Hodgkin Lymphoma

Symptoms & Phenotypes for Childhood Non-Hodgkin Lymphoma

GenomeRNAi Phenotypes related to Childhood Non-Hodgkin Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.62 ATM TIMP1

MGI Mouse Phenotypes related to Childhood Non-Hodgkin Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.62 ATM TIMP1

Drugs & Therapeutics for Childhood Non-Hodgkin Lymphoma

Drugs for Childhood Non-Hodgkin Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
2
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
3
Nystatin Approved, Vet_approved Phase 3 1400-61-9 11953884
4
deoxycholic acid Approved Phase 3 83-44-3 222528
5
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
6
leucovorin Approved Phase 3 58-05-9 143 6006
7
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
8
Mercaptopurine Approved Phase 3 50-44-2 667490
9
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
10
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
11
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
12
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
14
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
15
Daunorubicin Approved Phase 3 20830-81-3 30323
16
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
17
Thioguanine Approved Phase 3 154-42-7 2723601
18
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
19
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
20
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
21
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
22
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
23
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
24 Cyclosporins Phase 3
25 Antifungal Agents Phase 3
26 Calcineurin Inhibitors Phase 3
27 14-alpha Demethylase Inhibitors Phase 3
28 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
29 Cytochrome P-450 CYP3A Inhibitors Phase 3
30 Steroid Synthesis Inhibitors Phase 3
31 Amphotericin B, deoxycholate drug combination Phase 3
32 Liposomal amphotericin B Phase 3
33 Cholagogues and Choleretics Phase 3
34 Antiparasitic Agents Phase 3
35 Cytochrome P-450 Enzyme Inhibitors Phase 3
36 Ionophores Phase 3
37 Antiprotozoal Agents Phase 3
38 Folic Acid Antagonists Phase 3
39 Immunologic Factors Phase 3
40 Anti-Infective Agents Phase 3
41 Folate Phase 3
42 Vitamin B Complex Phase 3
43 Vitamin B9 Phase 3
44 Immunosuppressive Agents Phase 3
45 Dermatologic Agents Phase 3
46 Nucleic Acid Synthesis Inhibitors Phase 3
47 Antimetabolites Phase 3
48 Antimetabolites, Antineoplastic Phase 3
49 Antirheumatic Agents Phase 3
50 Hormones Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Postgrafting Methotrexate and Cyclosporine for the Prevention of Graft-Versus-Host Disease Completed NCT00002456 Phase 3 cyclosporine;methotrexate
2 A PROSPECTIVE RANDOMIZED, DOUBLE-BLIND, COMPARATIVE, MULTICENTER STUDY TO EVALUATE EFFICACY AND SAFETY OF NYSTATIN AND AMPHOTERICIN B FOR EMPIRIC ANTIFUNGAL TREATMENT IN NEUTROPENIC PATIENTS Completed NCT00002742 Phase 3 amphotericin B deoxycholate;nystatin
3 Treatment Protocol for T-Cell and B-Precursor Cell Lymphoblastic Lymphoma of the European Inter-group Co-operation on Childhood Non-Hodgkin-Lymphoma (EICNHL) Terminated NCT00275106 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisolone;thioguanine;vincristine sulfate
4 Pediatric Phase I Trial of BL22 for Refractory CD22-Positive Leukemias and Lymphomas Suspended NCT00077493 Phase 1 BL22 immunotoxin
5 Metabolic Syndrome in Childhood Cancer Survivors Completed NCT00920738
6 Rare And Cutaneous Non-Hodgkin Lymphoma Registry Active, not recruiting NCT01000753

Search NIH Clinical Center for Childhood Non-Hodgkin Lymphoma

Genetic Tests for Childhood Non-Hodgkin Lymphoma

Anatomical Context for Childhood Non-Hodgkin Lymphoma

MalaCards organs/tissues related to Childhood Non-Hodgkin Lymphoma:

41
T Cells, B Cells, Endothelial, Brain, Bone, Bone Marrow, Spinal Cord

Publications for Childhood Non-Hodgkin Lymphoma

Articles related to Childhood Non-Hodgkin Lymphoma:

(show top 50) (show all 79)
# Title Authors PMID Year
1
Clinical Characteristics and Treatment Outcomes of Pediatric Patients with non-Hodgkin Lymphoma in East Asia. 38
31352772 2019
2
Seroepidemiological analysis and literature review of the prevalence of Epstein-Barr virus and herpesvirus infections in pediatric cases with non-Hodgkin lymphoma in Central Europe. 38
30977593 2019
3
Long-term survivors of childhood, adolescent and young adult non-Hodgkin lymphoma. 38
30714126 2019
4
Outcome of pediatric non-Hodgkin lymphoma in Central America: A report of the Association of Pediatric Hematology Oncology of Central America (AHOPCA). 38
30677231 2019
5
Fluorodeoxyglucose Detected Changes in Brain Metabolism After Chemotherapy in Pediatric Non-Hodgkin Lymphoma. 38
30630683 2019
6
Pediatric non-Hodgkin lymphoma: Characteristics, stratification, and treatment at a single institute in Thailand. 38
30734424 2019
7
[Recent advances in pediatric non-Hodgkin lymphoma. Report on a retrospective single-center cohort and review of the literature]. 38
30540862 2018
8
Outcome of Early Stage Pediatric Non-Lymphoblastic Non-Hodgkin Lymphoma. 38
29417460 2018
9
A Case of ALK+ Anaplastic Large-Cell Lymphoma With Aberrant Myeloperoxidase Expression and Initial Cutaneous Presentation. 38
29905579 2018
10
Neurocognitive, psychosocial, and quality-of-life outcomes in adult survivors of childhood non-Hodgkin lymphoma. 38
28915338 2018
11
Contribution of solid organ transplant recipients to the pediatric non-hodgkin lymphoma burden in the United States. 38
28759103 2017
12
Late outcomes of adult survivors of childhood non-Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study. 38
27860222 2017
13
Management of Non-Hodgkin Lymphoma: ICMR Consensus Document. 38
28378140 2017
14
Recent progress in the treatment of pediatric lymphoma in Japan. 38
28978862 2017
15
Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents. 38
27515251 2016
16
Serial assessment of circulating T regulatory cells and T helper 17 cells in pediatric non-Hodgkin lymphoma: a prospective study. 38
26690272 2016
17
Pediatric B-Cell Lymphoma With Lymphoblastic Morphology, TdT Expression, MYC Rearrangement, and Features Overlapping With Burkitt Lymphoma. 38
26785246 2016
18
Vascular endothelial growth factor expression in pediatric non-Hodgkin lymphoma: A prospective study. 38
27184774 2016
19
Primary cutaneous precursor B cell lymphoblastic lymphoma in a child, complicated by fatal disseminated varicella zoster virus. 38
25959984 2015
20
Non-Hodgkin lymphoma in children with an associated inherited condition: A retrospective analysis of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP). 38
26011068 2015
21
Revised International Pediatric Non-Hodgkin Lymphoma Staging System. 38
25940716 2015
22
International Pediatric Non-Hodgkin Lymphoma Response Criteria. 38
25940725 2015
23
Childhood acute lymphoblastic leukemia-associated risk-loci IKZF1, ARID5B and CEBPE and risk of pediatric non-Hodgkin lymphoma: a report from the Berlin-Frankfurt-Münster Study Group. 38
25005032 2015
24
Disease patterns of pediatric non-Hodgkin lymphoma: A study from a developing area in Egypt. 38
25469284 2015
25
Clinical characteristics and treatment outcomes of children with anaplastic large cell lymphoma: a single center experience. 38
25548758 2014
26
Histone deacetylase inhibitor prevents cell growth in Burkitt's lymphoma by regulating PI3K/Akt pathways and leads to upregulation of miR-143, miR-145, and miR-101. 38
24577510 2014
27
Neurological complication of non Hodgkin lymphoma in childhood: experience from a single center in Turkey. 38
23989474 2014
28
Characteristics and outcome of pediatric non-Hodgkin lymphoma patients with ovarian infiltration at presentation. 38
23868611 2013
29
Subcutaneous Panniculitis-like T-cell lymphoma in two pediatric patients: an HIV-positive adolescent and a 4-month-old infant. 38
23092204 2013
30
Non-Hodgkin lymphoma in children and adolescents. 38
23700066 2013
31
Rapid detection of neoplastic cells in serous cavity effusions in children with flow cytometry immunophenotyping. 38
22288605 2012
32
Roles and limitations of FDG PET in pediatric non-Hodgkin lymphoma. 38
22691506 2012
33
Endocrine late sequelae in long-term survivors of childhood non-Hodgkin lymphoma. 38
22048153 2012
34
Is rituximab approved in pediatric non Hodgkin lymphoma? 38
22700674 2012
35
Pediatric non-Hodgkin lymphoma: a retrospective 14-year experience with Berlin-Frankfurt-Münster (BFM) protocols from a tertiary care hospital in Serbia. 38
22376014 2012
36
Agreement between diagnoses of childhood lymphoma assigned in Uganda and by an international reference laboratory. 38
23277743 2012
37
High-dose busulfan and cyclophosphamide as a conditioning regimen for autologous peripheral blood stem cell transplantation in childhood non-Hodgkin lymphoma patients: a long-term follow-up study. 38
21358341 2011
38
Acute onset flaccid quadriparesis in pediatric non-Hodgkin lymphoma: vincristine induced or Guillain-Barré syndrome? 38
20544812 2010
39
Rare pediatric non-hodgkin lymphoma. 38
20490722 2010
40
Jaundice as a presenting manifestation of pediatric non-Hodgkin lymphoma: etiology, management, and outcome. 38
20445407 2010
41
Cavernous sinus syndrome as the initial presentation of childhood non-hodgkin lymphoma. 38
19645404 2009
42
Possible Mitochondria-Associated Enzymatic Role in Non-Hodgkin Lymphoma Residual Disease. 38
19936279 2008
43
Pediatric diffuse large B-cell lymphoma demonstrates a high proliferation index, frequent c-Myc protein expression, and a high incidence of germinal center subtype: Report of the French-American-British (FAB) international study group. 38
18493992 2008
44
Pediatric non-Hodgkin lymphoma. 38
20425462 2008
45
[Correlation of Epstein-Barr virus infection and childhood lymphoma]. 38
18953837 2008
46
Treatment of pediatric non-Hodgkin lymphoma in Hungary: 15 years experience with NHL-BFM 90 and 95 protocols. 38
17366531 2008
47
Role of gelatinases (MMP-2 and MMP-9), TIMP-1, vascular endothelial growth factor (VEGF), and microvessel density on the clinicopathological behavior of childhood non-Hodgkin lymphoma. 38
18231955 2008
48
[Malignant lymphoma]. 38
17301521 2007
49
Diagnosis and treatment of childhood non-hodgkin lymphoma. 38
18024642 2007
50
ATM alterations in childhood non-Hodgkin lymphoma. 38
16631465 2006

Variations for Childhood Non-Hodgkin Lymphoma

Expression for Childhood Non-Hodgkin Lymphoma

Search GEO for disease gene expression data for Childhood Non-Hodgkin Lymphoma.

Pathways for Childhood Non-Hodgkin Lymphoma

Pathways related to Childhood Non-Hodgkin Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.83 TIMP1 ATM

GO Terms for Childhood Non-Hodgkin Lymphoma

Sources for Childhood Non-Hodgkin Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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