MCID: CHL151
MIFTS: 26

Childhood Non-Hodgkin Lymphoma

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Childhood Non-Hodgkin Lymphoma

MalaCards integrated aliases for Childhood Non-Hodgkin Lymphoma:

Name: Childhood Non-Hodgkin Lymphoma 54
Pediatric Non-Hodgkin Lymphoma 54

Classifications:



Summaries for Childhood Non-Hodgkin Lymphoma

MalaCards based summary : Childhood Non-Hodgkin Lymphoma, also known as pediatric non-hodgkin lymphoma, is related to lymphoma, hodgkin, classic and lymphoma, non-hodgkin, familial. An important gene associated with Childhood Non-Hodgkin Lymphoma is ATM (ATM Serine/Threonine Kinase), and among its related pathways/superpathways is Immune response IFN alpha/beta signaling pathway. The drugs leucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and brain, and related phenotypes are Reduced mammosphere formation and neoplasm

Related Diseases for Childhood Non-Hodgkin Lymphoma

Diseases related to Childhood Non-Hodgkin Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 lymphoma, hodgkin, classic 10.7
2 lymphoma, non-hodgkin, familial 10.7
3 lymphoma 10.7
4 yemenite deaf-blind hypopigmentation syndrome 10.0
5 histoplasmosis 10.0
6 leukemia, acute lymphoblastic 10.0
7 acute lymphoblastic leukemia, childhood 10.0
8 leukemia 10.0
9 lymphocytic leukemia 10.0
10 guillain-barre syndrome 10.0

Graphical network of the top 20 diseases related to Childhood Non-Hodgkin Lymphoma:



Diseases related to Childhood Non-Hodgkin Lymphoma

Symptoms & Phenotypes for Childhood Non-Hodgkin Lymphoma

GenomeRNAi Phenotypes related to Childhood Non-Hodgkin Lymphoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.62 ATM TIMP1

MGI Mouse Phenotypes related to Childhood Non-Hodgkin Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.62 ATM TIMP1

Drugs & Therapeutics for Childhood Non-Hodgkin Lymphoma

Drugs for Childhood Non-Hodgkin Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 3,Phase 1,Phase 2 58-05-9 143 6006
2
Methotrexate Approved Phase 3,Phase 1,Phase 2 1959-05-2, 59-05-2 126941
3
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
4
deoxycholic acid Approved Phase 3 83-44-3 222528
5
Nystatin Approved, Vet_approved Phase 3 1400-61-9 11953884
6
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
7
Cytarabine Approved, Experimental, Investigational Phase 3,Phase 2,Phase 1 147-94-4, 65-46-3 6253
8
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
9
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 1 302-25-0
10
Vincristine Approved, Investigational Phase 3,Phase 1 2068-78-2, 57-22-7 5978
11
Doxorubicin Approved, Investigational Phase 3,Phase 1 23214-92-8 31703
12
Prednisolone Approved, Vet_approved Phase 3,Phase 1 50-24-8 5755
13
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1 83-43-2 6741
14
Methylprednisolone hemisuccinate Approved Phase 3,Phase 1 2921-57-5
15
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
17
Daunorubicin Approved Phase 3 20830-81-3 30323
18
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
19
Mercaptopurine Approved Phase 3,Phase 1,Phase 2 50-44-2 667490
20
Thioguanine Approved Phase 3,Phase 1,Phase 2 154-42-7 2723601
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2 59-30-3 6037
22
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
23
Prednisolone hemisuccinate Experimental Phase 3,Phase 1 2920-86-7
24
Doxil Approved June 1999 Phase 3,Phase 1 31703
25 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 1,Phase 2
26 Cyclosporins Phase 3,Phase 2,Phase 1
27 Folic Acid Antagonists Phase 3,Phase 1,Phase 2
28 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
29 Antifungal Agents Phase 3,Phase 2,Phase 1
30 Antirheumatic Agents Phase 3,Phase 2,Phase 1
31 Dermatologic Agents Phase 3,Phase 2,Phase 1
32 Anti-Infective Agents Phase 3,Phase 2,Phase 1
33 Antimetabolites Phase 3,Phase 2,Phase 1
34 Vitamin B9 Phase 3,Phase 1,Phase 2
35 Immunologic Factors Phase 3,Phase 2,Phase 1
36 Folate Phase 3,Phase 1,Phase 2
37 Vitamin B Complex Phase 3,Phase 1,Phase 2
38 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
39 Calcineurin Inhibitors Phase 3,Phase 2,Phase 1
40 Amphotericin B, deoxycholate drug combination Phase 3
41 Hormones Phase 3,Phase 1
42 Steroid Synthesis Inhibitors Phase 3
43 Cytochrome P-450 CYP3A Inhibitors Phase 3
44 Cytochrome P-450 Enzyme Inhibitors Phase 3
45 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
47 Hormone Antagonists Phase 3,Phase 1
48 Antiparasitic Agents Phase 3
49 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
50 Gastrointestinal Agents Phase 3,Phase 1

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Graft-Versus-Host Disease Prevention in Treating Patients Who Are Undergoing Bone Marrow Transplantation Completed NCT00002456 Phase 3 cyclosporine;methotrexate
2 Antifungal Therapy for Fever and Neutropenia in Patients Receiving Treatment for Hematologic Cancer Completed NCT00002742 Phase 3 amphotericin B deoxycholate;nystatin
3 Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma Terminated NCT00275106 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisolone;thioguanine;vincristine sulfate
4 Improve the Survival Rate of Chinese Children and Adolescents With Non-Hodgkin's Lymphoma Completed NCT01761500 Phase 2
5 Statin Therapy in Young Adult Survivors of Childhood Cancer Completed NCT01733953 Phase 2 Atorvastatin;Sugar Pill (Placebo)
6 Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia Completed NCT01008462 Phase 2 Carmustine;Cyclophosphamide;Cytarabine;Etoposide;Fludarabine Phosphate;Melphalan;Mycophenolate Mofetil;Tacrolimus
7 Phase II Open Label Trial to Determine Safety & Efficacy of Tisagenlecleucel in Pediatric Non-Hodgkin Lymphoma Patients Recruiting NCT03610724 Phase 2
8 MB-CART19.1 r/r CD19+ B-cell Malignancies (BCM) Recruiting NCT03853616 Phase 1, Phase 2
9 Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) Recruiting NCT03233204 Phase 2 Olaparib
10 Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial) Recruiting NCT03220035 Phase 2 Vemurafenib
11 Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) Recruiting NCT03213691 Phase 2 Selumetinib;Selumetinib Sulfate
12 Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) Recruiting NCT03210714 Phase 2 Erdafitinib
13 Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) Recruiting NCT03155620 Phase 2 Ensartinib;Erdafitinib;Larotrectinib;Olaparib;Palbociclib;PI3K/mTOR Inhibitor LY3023414;Selumetinib Sulfate;Tazemetostat;Ulixertinib;Vemurafenib
14 Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial) Recruiting NCT03213652 Phase 2 Ensartinib
15 Mitoxantrone and Clofarabine for Treatment of Recurrent NHL or Acute Leukemia Recruiting NCT01842672 Phase 1, Phase 2 Clofarabine;Mitoxantrone
16 Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) Recruiting NCT03213665 Phase 2 Tazemetostat
17 Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant Recruiting NCT01251575 Phase 2 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil;Sirolimus
18 Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial) Recruiting NCT03213704 Phase 2 Larotrectinib;Larotrectinib Sulfate
19 Autologous Stem Cell Transplant Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Lymphoma Active, not recruiting NCT00005803 Phase 1, Phase 2 Carmustine;Cyclophosphamide;Cyclosporine;Cytarabine;Etoposide;Fludarabine Phosphate;Melphalan;Mycophenolate Mofetil
20 Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer Active, not recruiting NCT00027820 Phase 1, Phase 2 Fludarabine Phosphate;Cyclosporine;Mycophenolate Mofetil
21 Study of 6-Thioguanine in Combination With 6-Mercaptopurine During Maintenance Therapy of Childhood Lymphoma Withdrawn NCT02141100 Phase 1, Phase 2 6-thioguanine
22 Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL) Recruiting NCT03792256 Phase 1 Palbociclib;Cytarabine;Methotrexate;Hydrocortisone;Doxorubicin;Prednisolone;Vincristine;Pegaspargase
23 BL22 Immunotoxin In Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma Suspended NCT00077493 Phase 1 BL22 immunotoxin
24 Sirolimus and Mycophenolate Mofetil in Preventing GVHD in Patients With Hematologic Malignancies Undergoing HSCT Terminated NCT02728700 Phase 1 Mycophenolate Mofetil;Sirolimus
25 Metabolic Syndrome in Childhood Cancer Survivors Completed NCT00920738
26 Collecting and Storing Samples of Bone Marrow and Blood From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma Active, not recruiting NCT00897325
27 Dietary and Exercise Interventions in Preventing Cardiovascular Disease in Younger Survivors of Leukemia, Lymphoma, or Brain Tumors Withdrawn NCT02000986 Not Applicable

Search NIH Clinical Center for Childhood Non-Hodgkin Lymphoma

Genetic Tests for Childhood Non-Hodgkin Lymphoma

Anatomical Context for Childhood Non-Hodgkin Lymphoma

MalaCards organs/tissues related to Childhood Non-Hodgkin Lymphoma:

42
Bone, Bone Marrow, Brain, Kidney, Testes, B Cells, Endothelial

Publications for Childhood Non-Hodgkin Lymphoma

Articles related to Childhood Non-Hodgkin Lymphoma:

(show all 47)
# Title Authors Year
1
Pediatric non-Hodgkin lymphoma: Characteristics, stratification, and treatment at a single institute in Thailand. ( 30734424 )
2019
2
Outcome of pediatric non-Hodgkin lymphoma in Central America: A report of the Association of Pediatric Hematology Oncology of Central America (AHOPCA). ( 30677231 )
2019
3
Fluorodeoxyglucose Detected Changes in Brain Metabolism After Chemotherapy in Pediatric Non-Hodgkin Lymphoma. ( 30630683 )
2019
4
Neurocognitive, psychosocial, and quality-of-life outcomes in adult survivors of childhood non-Hodgkin lymphoma. ( 28915338 )
2018
5
Late outcomes of adult survivors of childhood non-Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study. ( 27860222 )
2017
6
Contribution of solid organ transplant recipients to the pediatric non-hodgkin lymphoma burden in the United States. ( 28759103 )
2017
7
Vascular endothelial growth factor expression in pediatric non-Hodgkin lymphoma: A prospective study. ( 27184774 )
2016
8
Serial assessment of circulating T regulatory cells and T helper 17 cells in pediatric non-Hodgkin lymphoma: a prospective study. ( 26690272 )
2016
9
Revised International Pediatric Non-Hodgkin Lymphoma Staging System. ( 25940716 )
2015
10
International Pediatric Non-Hodgkin Lymphoma Response Criteria. ( 25940725 )
2015
11
Disease patterns of pediatric non-Hodgkin lymphoma: A study from a developing area in Egypt. ( 25469284 )
2015
12
Childhood acute lymphoblastic leukemia-associated risk-loci IKZF1, ARID5B and CEBPE and risk of pediatric non-Hodgkin lymphoma: a report from the Berlin-Frankfurt-Münster Study Group. ( 25005032 )
2015
13
Characteristics and outcome of pediatric non-Hodgkin lymphoma patients with ovarian infiltration at presentation. ( 23868611 )
2013
14
Endocrine late sequelae in long-term survivors of childhood non-Hodgkin lymphoma. ( 22048153 )
2012
15
Roles and limitations of FDG PET in pediatric non-Hodgkin lymphoma. ( 22691506 )
2012
16
Is rituximab approved in pediatric non Hodgkin lymphoma? ( 22700674 )
2012
17
Pediatric non-Hodgkin lymphoma: a retrospective 14-year experience with Berlin-Frankfurt-Münster (BFM) protocols from a tertiary care hospital in Serbia. ( 22376014 )
2012
18
High-dose busulfan and cyclophosphamide as a conditioning regimen for autologous peripheral blood stem cell transplantation in childhood non-Hodgkin lymphoma patients: a long-term follow-up study. ( 21358341 )
2011
19
Acute onset flaccid quadriparesis in pediatric non-Hodgkin lymphoma: vincristine induced or Guillain-Barré syndrome? ( 20544812 )
2010
20
Jaundice as a presenting manifestation of pediatric non-Hodgkin lymphoma: etiology, management, and outcome. ( 20445407 )
2010
21
Rare pediatric non-hodgkin lymphoma. ( 20490722 )
2010
22
Cavernous sinus syndrome as the initial presentation of childhood non-hodgkin lymphoma. ( 19645404 )
2009
23
Role of gelatinases (MMP-2 and MMP-9), TIMP-1, vascular endothelial growth factor (VEGF), and microvessel density on the clinicopathological behavior of childhood non-Hodgkin lymphoma. ( 18231955 )
2008
24
Pediatric non-Hodgkin lymphoma. ( 20425462 )
2008
25
Treatment of pediatric non-Hodgkin lymphoma in Hungary: 15 years experience with NHL-BFM 90 and 95 protocols. ( 17366531 )
2008
26
Diagnosis and treatment of childhood non-hodgkin lymphoma. ( 18024642 )
2007
27
ATM alterations in childhood non-Hodgkin lymphoma. ( 16631465 )
2006
28
Methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and risk of pediatric non-Hodgkin lymphoma in a German study population. ( 15632215 )
2005
29
Acute blindness as a presenting sign in childhood non-Hodgkin lymphoma. ( 12544777 )
2003
30
High survival rate in childhood non-Hodgkin lymphoma without CNS involvement: results of BFM 95 study in Kuwait. ( 12554521 )
2003
31
Assessment of minimal residual disease in childhood non-hodgkin lymphoma by polymerase chain reaction using patient-specific primers. ( 12571460 )
2003
32
Childhood non-Hodgkin lymphoma presenting as hemophagocytic syndrome. ( 11787866 )
2002
33
Assessment of Epstein-Barr virus association with pediatric non-hodgkin lymphoma in immunocompetent and in immunocompromised patients in Argentina. ( 11860309 )
2002
34
Second malignancy after treatment of childhood non-Hodgkin lymphoma. ( 11745271 )
2001
35
Anterior mediastinal mass in childhood non-Hodgkin lymphoma: dilemma of post-therapy imaging. ( 10657883 )
2000
36
Primary pleural lymphoma: an unusual presentation of childhood non-Hodgkin lymphoma. ( 11127402 )
2000
37
Primary epidural non-Hodgkin lymphoma: spinal cord compression syndrome as the initial form of presentation in childhood non-Hodgkin lymphoma. ( 9950197 )
1999
38
Factors contributing to the prognostic significance of bone marrow involvement in childhood non-Hodgkin lymphoma. ( 8058006 )
1994
39
Imaging of childhood non-Hodgkin lymphoma: assessment by histologic subtype. ( 8128042 )
1994
40
Cytogenetic characteristics of childhood non-Hodgkin lymphoma. ( 1623487 )
1992
41
Biology and staging of childhood non-Hodgkin lymphoma. ( 3063151 )
1988
42
Short-term intensive therapy for childhood non-Hodgkin lymphoma. ( 2884500 )
1987
43
Short-term intensive therapy for childhood non-Hodgkin lymphoma. ( 2886850 )
1987
44
Use of cytosar in pediatric non-Hodgkin lymphoma. ( 6962321 )
1982
45
Predictive ability of Lukes-Collins classification for immunologic phenotypes of childhood non-Hodgkin lymphoma: an institutional series and literature review. ( 6975158 )
1981
46
A new therapy schedule for pediatric non-Hodgkin lymphoma toxicity with preliminary results. ( 7003336 )
1980
47
Histoplasmosis mimicking childhood non-Hodgkin lymphoma. ( 522825 )
1979

Variations for Childhood Non-Hodgkin Lymphoma

Expression for Childhood Non-Hodgkin Lymphoma

Search GEO for disease gene expression data for Childhood Non-Hodgkin Lymphoma.

Pathways for Childhood Non-Hodgkin Lymphoma

Pathways related to Childhood Non-Hodgkin Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.83 ATM TIMP1

GO Terms for Childhood Non-Hodgkin Lymphoma

Sources for Childhood Non-Hodgkin Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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