MCID: CHL006
MIFTS: 36

Childhood Oligodendroglioma

Categories: Cancer diseases

Aliases & Classifications for Childhood Oligodendroglioma

MalaCards integrated aliases for Childhood Oligodendroglioma:

Name: Childhood Oligodendroglioma 12 15
Oligodendroglioma, Childhood 73
Pediatric Oligodendroglioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3183
MeSH 44 D009837
NCIt 50 C4045
UMLS 73 C0280475

Summaries for Childhood Oligodendroglioma

MalaCards based summary : Childhood Oligodendroglioma, also known as oligodendroglioma, childhood, is related to oligodendroglioma and cerebellar astrocytoma, and has symptoms including seizures and headache. An important gene associated with Childhood Oligodendroglioma is PLPP3 (Phospholipid Phosphatase 3), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Carmustine and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone.

Related Diseases for Childhood Oligodendroglioma

Diseases related to Childhood Oligodendroglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 29.6 GFAP IDH1 OLIG2 SYP TP73
2 cerebellar astrocytoma 10.2 IDH1 KIAA1549
3 pilocytic astrocytoma of cerebellum 10.2 IDH1 KIAA1549
4 mixed glioma 10.2 GFAP IDH1
5 glioma susceptibility 1 10.2 GFAP IDH1
6 spinal cord astrocytoma 10.2 GFAP IDH1
7 inflammatory mfh 10.1 GFAP MDM2
8 periosteal chondrosarcoma 10.1 IDH1 MDM2
9 fibrillary astrocytoma 10.1 GFAP IDH1 KIAA1549
10 pilocytic astrocytoma 10.1 GFAP IDH1 KIAA1549
11 periosteal osteogenic sarcoma 10.1 IDH1 MDM2
12 desmoplastic infantile ganglioglioma 10.1 GFAP SYP
13 lung combined type small cell carcinoma 10.1 GFAP SYP
14 cellular ependymoma 10.1 GFAP SYP
15 chordoid meningioma 10.1 GFAP SYP
16 central nervous system primitive neuroectodermal neoplasm 10.1 GFAP SYP
17 clear cell ependymoma 10.1 GFAP SYP
18 chiari malformation 10.1 GFAP SYP
19 cerebral neuroblastoma 10.1 GFAP SYP
20 subependymal glioma 10.1 GFAP SYP
21 astroblastoma 10.1 GFAP SYP
22 pineal gland cancer 10.1 GFAP SYP
23 melanotic neuroectodermal tumor 10.1 GFAP SYP
24 obstructive hydrocephalus 10.1 GFAP SYP
25 medulloepithelioma 10.1 GFAP SYP
26 pineocytoma 10.1 GFAP SYP
27 subependymoma 10.1 GFAP SYP
28 partial motor epilepsy 10.1 RBFOX3 SYP
29 pineoblastoma 10.1 GFAP SYP
30 gangliocytoma 10.1 RBFOX3 SYP
31 brain glioma 10.1 GFAP IDH1
32 papilloma of choroid plexus 10.1 GFAP SYP
33 cauda equina neoplasm 10.0 RBFOX3 SYP
34 sella turcica neoplasm 10.0 RBFOX3 SYP
35 tuberculum sellae meningioma 10.0 RBFOX3 SYP
36 central neurocytoma 10.0 GFAP SYP
37 gliomatosis cerebri 10.0 GFAP IDH1 MDM2
38 binswanger's disease 10.0 GFAP SYP
39 peripheral osteosarcoma 10.0 IDH1 MDM2
40 cystic teratoma 10.0 GFAP SYP
41 subependymal giant cell astrocytoma 10.0 GFAP SYP
42 central nervous system benign neoplasm 10.0 GFAP SYP
43 von economo's disease 10.0 GFAP SNCA
44 nodular ganglioneuroblastoma 10.0 MDM2 SYP
45 nervous system benign neoplasm 10.0 GFAP SYP
46 benign glioma 10.0 GFAP KIAA1549 SYP
47 extraventricular neurocytoma 10.0 GFAP IDH1 SYP
48 dysembryoplastic neuroepithelial tumor 10.0 GFAP IDH1 SYP
49 pilomyxoid astrocytoma 10.0 GFAP KIAA1549 SYP
50 angiocentric glioma 10.0 GFAP IDH1 SYP

Graphical network of the top 20 diseases related to Childhood Oligodendroglioma:



Diseases related to Childhood Oligodendroglioma

Symptoms & Phenotypes for Childhood Oligodendroglioma

UMLS symptoms related to Childhood Oligodendroglioma:


seizures, headache

Drugs & Therapeutics for Childhood Oligodendroglioma

Drugs for Childhood Oligodendroglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 365)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carmustine Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 154-93-8 2578
2
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 57-22-7, 2068-78-2 5978
3
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
4
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
5
leucovorin Approved Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
6
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 6055-19-2, 50-18-0 2907
7
Thiotepa Approved, Investigational Phase 3,Phase 2,Phase 1 52-24-4 5453
8
Methotrexate Approved Phase 3,Phase 2,Not Applicable 59-05-2, 1959-05-2 126941
9
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
10
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 85622-93-1 5394
11
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
12
Dacarbazine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 4342-03-4 5351166
13
Procarbazine Approved, Investigational Phase 3,Phase 2,Phase 1 671-16-9 4915
14
Lomustine Approved, Investigational Phase 3,Phase 2,Phase 1 13010-47-4 3950
15
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
16
Ondansetron Approved Phase 3 99614-02-5 4595
17
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
18
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
20
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
21
Histamine Approved, Investigational Phase 3,Phase 2 51-45-6, 75614-87-8 774
22
Cyproheptadine Approved Phase 3,Phase 2 129-03-3 2913
23
Dopamine Approved Phase 3,Early Phase 1,Not Applicable 51-61-6, 62-31-7 681
24
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
25
Isotretinoin Approved Phase 3,Phase 1 4759-48-2 5538 5282379
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
27
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 1 302-79-4 5538 444795
28 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
29 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
32 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
33 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
34 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
36 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
37 Vitamin B Complex Phase 3,Phase 2,Phase 1,Not Applicable
38 Dermatologic Agents Phase 3,Phase 1,Phase 2,Not Applicable
39 Folic Acid Antagonists Phase 3,Phase 2,Not Applicable
40 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Not Applicable
41 Antimetabolites Phase 3,Phase 2,Phase 1,Not Applicable
42 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
43 Folate Phase 3,Phase 2,Phase 1,Not Applicable
44 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
45 Vitamin B9 Phase 3,Phase 2,Phase 1,Not Applicable
46 Antiemetics Phase 3,Phase 2,Phase 1
47 Emetics Phase 3,Phase 2
48 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
49 Liver Extracts Phase 3,Phase 2,Phase 1
50 Keratolytic Agents Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 366)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Newly Diagnosed Malignant Glioma Unknown status NCT01656980 Phase 3 Carmustine
2 Carboplatin Plus Vincristine in Treating Children and Adolescents With Low Grade Glioma Unknown status NCT00003015 Phase 3 carboplatin;vincristine sulfate
3 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;methotrexate;temozolomide;thiotepa;vincristine sulfate
4 Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma Completed NCT00002840 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
5 Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic Oligodendroglioma Completed NCT00002569 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
6 Randomized Phase III Study of Sequential Radiochemotherapy of Anaplastic Glioma With PCV or Temozolomide Completed NCT00717210 Phase 3 Temozolomide
7 Radiation Therapy or Temozolomide in Treating Patients With Gliomas Completed NCT00182819 Phase 3 temozolomide
8 Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma Completed NCT00003375 Phase 2, Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
9 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
10 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
11 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
12 Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Glioma Recruiting NCT01649830 Phase 3 Temozolomide
13 Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma Recruiting NCT00887146 Phase 3 concomitant temozolomide (TMZ);procarbazine;adjuvant temozolomide (TMZ);CCNU;vincristine
14 Phase III Trial of Anaplastic Glioma Without 1p/19q LOH Active, not recruiting NCT00626990 Phase 3 temozolomide
15 Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma Active, not recruiting NCT00978458 Phase 3 temozolomide
16 Treatment Strategy for Low-grade Gliomas Terminated NCT00897377 Phase 3 Temozolomide
17 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
18 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
19 Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas Withdrawn NCT00003564 Phase 3 Isotretinoin;Procarbazine Hydrochloride
20 Phase I/II Trial of Safety and Anti-tumor Efficacy of AXL1717(Picropodophyllin) in the Treatment of Recurrent Malignant Astrocytomas Unknown status NCT01721577 Phase 1, Phase 2 AXL1717
21 A Prospective Cohort to Study the Effect of Temozolomide on IDH Mutational Low Grade Gliomas Unknown status NCT02209428 Phase 2 Temozolomide
22 A Study of 131I-TM601 in Adults With Recurrent Malignant Glioma Unknown status NCT00683761 Phase 1, Phase 2 131I-TM601
23 Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas Unknown status NCT02238496 Phase 2 Perifosine;Temsirolimus
24 Temozolomide in Treating Patients With Recurrent or Progressive Malignant Glioma Unknown status NCT00004204 Phase 2 temozolomide
25 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
26 Cisplatin and Temozolomide in Treating Young Patients With Malignant Glioma Unknown status NCT00360945 Phase 2 cisplatin;temozolomide
27 Radiation Therapy in Treating Young Patients With Gliomas Unknown status NCT00238264 Phase 2
28 Bevacizumab in Recurrent Grade II and III Glioma Unknown status NCT01164189 Phase 2 Temozolomide
29 Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors Unknown status NCT00281905 Phase 2 carboplatin;cisplatin;cyclophosphamide;methotrexate;vincristine sulfate
30 A Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain Unknown status NCT01403311 Phase 2 5-Aminolevuline Acid
31 Carmustine Followed By Surgery in Treating Patients With Recurrent Supratentorial Malignant Glioma or Metastatic Brain Neoplasm Unknown status NCT00009854 Phase 1, Phase 2 carmustine in ethanol
32 Temozolomide in Relapsed or Advanced Anaplastic Oligodendroglioma and Oligoastrocytoma: Single-arm, Phase II Trial Completed NCT01847235 Phase 2 Temozolomide
33 Temozolomide in Patients With Newly Diagnosed Anaplastic Oligodendroglioma and Mixed Oligoastrocytoma Completed NCT00362570 Phase 2 Temozolomide
34 Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With Oligodendroglioma Completed NCT00003101 Phase 2 busulfan;lomustine;procarbazine hydrochloride;thiotepa;vincristine sulfate
35 Temozolomide in Treating Patients With Newly Diagnosed Anaplastic Oligodendroglioma or Mixed Oligoastrocytoma Completed NCT00400816 Phase 2 temozolomide
36 Temozolomide in Treating Patients With Anaplastic Oligodendroglioma Completed NCT00003465 Phase 2 temozolomide
37 Temozolomide Plus Radiation Therapy in Treating Patients With Newly Diagnosed Anaplastic Oligodendrogliomas or Mixed Anaplastic Oligoastrocytomas Completed NCT00033280 Phase 2 temozolomide
38 Biological Therapy Following Surgery and Radiation Therapy in Treating Patients With Primary or Recurrent Astrocytoma or Oligodendroglioma Completed NCT00004024 Phase 2
39 Topotecan in Treating Patients With Recurrent Brain Tumors Completed NCT00003372 Phase 2 topotecan hydrochloride
40 Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma Completed NCT01663012 Phase 2 Etirinotecan pegol
41 Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Malignant Glioma Completed NCT00008008 Phase 2 cyclophosphamide;thiotepa
42 Prolonged Daily Temozolomide for Low-Grade Glioma Completed NCT00165360 Phase 2 Temozolomide
43 Phase II Trial of RAD001 in Patients With Recurrent Low Grade Glioma Completed NCT00823459 Phase 2 RAD001
44 Phase II Imatinib + Hydroxyurea in Treatment of Patients With Recurrent/Progressive Grade II Low-Grade Glioma (LGG) Completed NCT00615927 Phase 2 Imatinib Mesylate & Hydroxyurea
45 Tandutinib Plus Bevacizumab to Treat Recurrent Brain Tumors Completed NCT00667394 Phase 2 MLN-518 (Tandutinib)
46 Temozolomide in Treating Patients With Recurrent Oligodendroglial Tumors Completed NCT00003304 Phase 2 temozolomide
47 Chemotherapy in Treating Patients With Progressive or Recurrent Brain Tumors Completed NCT00012038 Phase 1, Phase 2 irofulven
48 Procarbazine in Treating Patients With Recurrent Brain Tumor Completed NCT00004004 Phase 1, Phase 2 procarbazine hydrochloride
49 Efficacy of Protracted Temozolomide in Patients With Progressive High Grade Glioma Completed NCT00575887 Phase 2 Temozolomide
50 The Effects of Continuous 28-day (28/28) Temozolomide Chemotherapy in Subjects With Recurrent Malignant Glioma Who Have Failed the Conventional 5-day (5/28) Treatment (P04601) Completed NCT00392171 Phase 2 Temozolomide

Search NIH Clinical Center for Childhood Oligodendroglioma

Genetic Tests for Childhood Oligodendroglioma

Anatomical Context for Childhood Oligodendroglioma

MalaCards organs/tissues related to Childhood Oligodendroglioma:

41
Brain, Liver, Bone, Lung, Spinal Cord, Pineal, Cerebellum

Publications for Childhood Oligodendroglioma

Articles related to Childhood Oligodendroglioma:

# Title Authors Year
1
Outcomes and Prognostic Factors in Pediatric Oligodendroglioma: A Population-Based Study. ( 29131101 )
2018
2
Predictors of clinical outcome in pediatric oligodendroglioma: meta-analysis of individual patient data and multiple imputation. ( 29192869 )
2018
3
Conventional and advanced (DTI/SWI) neuroimaging findings in pediatric oligodendroglioma. ( 25813856 )
2015

Variations for Childhood Oligodendroglioma

Expression for Childhood Oligodendroglioma

Search GEO for disease gene expression data for Childhood Oligodendroglioma.

Pathways for Childhood Oligodendroglioma

Pathways related to Childhood Oligodendroglioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 GFAP RBFOX3 SNCA SYP
2 10.7 GFAP OLIG2 SYP
3
Show member pathways
10.5 MDM2 TP73

GO Terms for Childhood Oligodendroglioma

Biological processes related to Childhood Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to cocaine GO:0042220 9.4 MDM2 SNCA
2 synaptic vesicle endocytosis GO:0048488 9.37 SNCA SYP
3 response to steroid hormone GO:0048545 9.32 IDH1 MDM2
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 SNCA SYP
5 regulation of neuronal synaptic plasticity GO:0048168 9.16 SNCA SYP
6 positive regulation of oligodendrocyte differentiation GO:0048714 8.96 OLIG2 TP73
7 response to magnesium ion GO:0032026 8.62 MDM2 SNCA

Molecular functions related to Childhood Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.16 DPYD IDH1
2 identical protein binding GO:0042802 9.1 GFAP IDH1 MDM2 SNCA SYP TP73
3 beta-tubulin binding GO:0048487 8.96 PDCD5 SNCA

Sources for Childhood Oligodendroglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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