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MCID: CHL006
MIFTS: 35

Childhood Oligodendroglioma

Categories: Bone diseases, Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Childhood Oligodendroglioma

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MalaCards integrated aliases for Childhood Oligodendroglioma:

Name: Childhood Oligodendroglioma 12 15
Oligodendroglioma, Childhood 71
Pediatric Oligodendroglioma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3183
MeSH 43 D009837
NCIt 49 C4045
UMLS 71 C0280475
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Summaries for Childhood Oligodendroglioma

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MalaCards based summary : Childhood Oligodendroglioma, also known as oligodendroglioma, childhood, is related to oligoastrocytoma and anaplastic oligodendroglioma, and has symptoms including seizures and headache. An important gene associated with Childhood Oligodendroglioma is KIAA1549 (KIAA1549), and among its related pathways/superpathways are Type I Interferon Signaling Pathways and Transcriptional misregulation in cancer. The drugs Cyclophosphamide and Thiotepa have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord.

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Related Diseases for Childhood Oligodendroglioma

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Diseases related to Childhood Oligodendroglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 oligoastrocytoma 30.3 MGMT IDH2
2 anaplastic oligodendroglioma 30.1 OLIG2 MGMT IDH2
3 oligodendroglioma 28.3 OLIG2 MGMT IDH2 IDH1 FUBP1 FGFR1
4 adult oligodendroglioma 26.8 OLIG2 KIAA1549 IDH2 IDH1 H3-3B H3-3A
5 enchondroma 10.4 IDH2 IDH1
6 breast duct papilloma 10.4 IDH2 IDH1
7 cytogenetically normal acute myeloid leukemia 10.4 IDH2 IDH1
8 intracranial chondrosarcoma 10.4 IDH2 IDH1
9 periosteal chondrosarcoma 10.4 IDH2 IDH1
10 breast hemangioma 10.4 IDH2 IDH1
11 juxtacortical chondroma 10.3 IDH2 IDH1
12 interval angle-closure glaucoma 10.3 IDH2 IDH1
13 undifferentiated pleomorphic sarcoma 10.3 IDH2 IDH1
14 diffuse intrinsic pontine glioma 10.3 H3-3B H3-3A
15 intraductal breast neoplasm 10.3 IDH2 IDH1
16 frontal lobe neoplasm 10.3 MGMT IDH1
17 bone giant cell sarcoma 10.3 H3-3B H3-3A
18 spinal cancer 10.3 KIAA1549 IDH1
19 malignant giant cell tumor 10.3 H3-3B H3-3A
20 glial tumor 10.3 OLIG2 IDH1
21 telangiectatic osteogenic sarcoma 10.3 H3-3B H3-3A
22 intraductal papilloma 10.3 IDH2 IDH1
23 colon leiomyoma 10.3 H3-3B H3-3A
24 glioblastoma classical subtype 10.3 MGMT IDH1
25 tanycytic ependymoma 10.3 OLIG2 IDH1
26 multiple enchondromatosis, maffucci type 10.2 IDH2 IDH1
27 spindle cell hemangioma 10.2 IDH2 IDH1
28 d-2-hydroxyglutaric aciduria 1 10.2 IDH2 IDH1
29 central nervous system rhabdomyosarcoma 10.2 MGMT IDH2 IDH1
30 gemistocytic astrocytoma 10.2 MGMT IDH2 IDH1
31 l-2-hydroxyglutaric aciduria 10.1 IDH2 IDH1
32 alpha thalassemia-x-linked intellectual disability syndrome 10.1 H3-3A ATRX
33 clear cell ependymoma 10.1 OLIG2 KIAA1549 IDH1
34 cerebellar liponeurocytoma 10.1 KIAA1549 FAM131B
35 enchondromatosis, multiple, ollier type 10.1 IDH2 IDH1 ATRX
36 bone giant cell tumor 10.1 H3-3B H3-3A
37 localized chondrosarcoma 10.1 IDH2 FGFR1
38 papillary craniopharyngioma 10.1 KIAA1549 FAM131B
39 spinal cord lipoma 10.0 MGMT FGFR1
40 subependymal glioma 10.0 KIAA1549 FAM131B
41 thoracic benign neoplasm 10.0 IDH2 IDH1
42 systemic mastocytosis 10.0 IDH2 IDH1 FGFR1
43 spinal cord glioma 10.0 KIAA1549 IDH1 H3-3B H3-3A
44 juvenile astrocytoma 10.0 KIAA1549 IDH1 FAM131B
45 clear cell chondrosarcoma 10.0 IDH2 IDH1 H3-3B H3-3A
46 chondroblastic osteosarcoma 10.0 IDH2 IDH1 H3-3B H3-3A
47 brain glioma 10.0 MGMT IDH2 IDH1 FUBP1
48 chondroblastoma 9.9 H3-3B H3-3A FGFR1
49 temporal lobe neoplasm 9.9 MGMT IDH1 FUBP1 ATRX
50 visual epilepsy 9.9

Graphical network of the top 20 diseases related to Childhood Oligodendroglioma:



Diseases related to Childhood Oligodendroglioma
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Symptoms & Phenotypes for Childhood Oligodendroglioma

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UMLS symptoms related to Childhood Oligodendroglioma:


seizures, headache
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Drugs & Therapeutics for Childhood Oligodendroglioma

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Drugs for Childhood Oligodendroglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 148)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
2
Thiotepa Approved, Investigational Phase 3 52-24-4 5453
3
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
4
leucovorin Approved Phase 3 58-05-9 6006 143
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
7
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
8
Ondansetron Approved Phase 3 99614-02-5 4595
9
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
10
Histamine Approved, Investigational Phase 3 51-45-6 774
11
Cyproheptadine Approved Phase 3 129-03-3 2913
12 Immunosuppressive Agents Phase 3
13 Antirheumatic Agents Phase 3
14 Folic Acid Antagonists Phase 3
15 Antimetabolites Phase 3
16 BB 1101 Phase 3
17 Autonomic Agents Phase 3
18 Emetics Phase 3
19 Antiemetics Phase 3
20 Gastrointestinal Agents Phase 3
21 Neurotransmitter Agents Phase 3
22 Dermatologic Agents Phase 3
23 Antipruritics Phase 3
24 Histamine H1 Antagonists Phase 3
25 Serotonin Agents Phase 3
26 Histamine Antagonists Phase 3
27
Histamine Phosphate Phase 3 51-74-1 65513
28 Serotonin Antagonists Phase 3
29 Anti-Allergic Agents Phase 3
30
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
31
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
32
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
33
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
34
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
35
Tamoxifen Approved Phase 2 10540-29-1 2733526
36
Sodium citrate Approved, Investigational Phase 2 68-04-2
37
Megestrol acetate Approved, Investigational, Vet_approved Phase 2 595-33-5 11683
38
Acetaminophen Approved Phase 2 103-90-2 1983
39
Iodine Approved, Investigational Phase 2 7553-56-2 807
40
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
41
Promethazine Approved, Investigational Phase 2 60-87-7 4927
42
Mechlorethamine Approved, Investigational Phase 1, Phase 2 51-75-2 4033
43
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
44
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
45
Tyrosine Approved, Investigational, Nutraceutical Phase 1, Phase 2 60-18-4 6057
46
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
47 Immunologic Factors Phase 2
48 Alkylating Agents Phase 2
49 Anticonvulsants Phase 1, Phase 2
50
Erlotinib Hydrochloride Phase 1, Phase 2 183319-69-9 176871

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Dose Intensive Chemotherapy for Children Less Than Ten Years of Age Newly-Diagnosed With Malignant Brain Tumors: A Pilot Study of Two Alternative Intensive Induction Chemotherapy Regimens, Followed by Consolidation With Myeloablative Chemotherapy (Thiotepa and Carboplatin, With or Without Etoposide) and Autologous Stem Cell Rescue [HEAD START III] Unknown status NCT00392886 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;methotrexate;temozolomide;thiotepa;vincristine sulfate
2 Ultimate Low Grade Glioma Study Unknown status NCT00003015 Phase 3 carboplatin;vincristine sulfate
3 Randomized Controlled Trial of Acupressure to Control Chemotherapy-Induced Nausea (CIN) in Children Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
4 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Management of Children Aged Less Than 3 Years With Brain Tumors Unknown status NCT00281905 Phase 2 carboplatin;cisplatin;cyclophosphamide;methotrexate;vincristine sulfate
6 Phase II Study of the Combination of Cisplatin + Temozolomide in Malignant Glial Tumours in Children and Adolescents at Diagnosis or in Relapse Unknown status NCT00360945 Phase 2 cisplatin;temozolomide
7 CAMP 013:- Tandem Thiotepa Regimen For Selected Malignant Gliomas:1) Primary Or Recurrent Glioblastoma Multiforme (GBM); and 2) Recurrent Anaplastic Astrocytomas (AA), Oligodendrogliomas (O), Oligoastrocytomas (OA), Ependymomas And Primitive Neuroectodermal Tumors (PNET) That Have Either Progressed After Primary Therapy Or Are Refractory To Standard Chemotherapy Completed NCT00008008 Phase 2 cyclophosphamide;thiotepa
8 A Phase II Trial of Rebeccamycin Analogue (NSC #655649) in Children With Solid Tumors Completed NCT00006102 Phase 2 becatecarin
9 Phase II Treatment of Children With Newly Diagnosed Malignant Central Nervous System Tumors With Temozolomide Prior to Radiation Therapy Completed NCT00005955 Phase 2 temozolomide
10 A Phase I/II Trial of a New Tyrosine Kinase Inhibitor (Tarceva; Erlotinib Hydrochloride; OSI-774) During and After Radiotherapy in the Treatment of Patients With Newly Diagnosed High Grade Glioma and Unfavorable Low-Grade Glioma Completed NCT00124657 Phase 1, Phase 2 Erlotinib hydrochloride
11 A Phase I/II Trial of Temodar in Pediatric Patients and Young Adults With High-Risk or Recurrent Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
12 PHASE II STUDY OF CARBOPLATIN (CBDCA) IN THE TREATMENT OF CHILDREN AND ADULTS WITH PROGRESSIVE LOW GRADE GLIOMAS Completed NCT00002749 Phase 2 carboplatin
13 A Phase II Study of Conformal Radiotherapy In Patients With Low-Grade Gliomas Completed NCT00238264 Phase 2
14 Treatment of Newly Diagnosed High-Grade Gliomas in Patients Ages Greater Than or Equal to 3 and Less Than or Equal to 21 Years With a Phase II Irinotecan Window Followed by Radiation Therapy and Temozolomide Completed NCT00004068 Phase 2 irinotecan hydrochloride;temozolomide
15 Cisplatin, Doxorubicin and Tamoxifen in the Treatment of Incurable Soft Tissue and Endocrine Malignancies Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
16 The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment Related Cachexia Completed NCT00066248 Phase 2 cyproheptadine hydrochloride;megestrol acetate
17 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
18 Dasatinib With Ifosfamide, Carboplatin, Etoposide: A Pediatric Phase I/II Trial Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
19 A Phase I/II Study Of A Recombinant Chimeric Protein Composed Of Transforming Growth Factor (TGF)-a And A Mutated Pseudomonas Exotoxin Termed PE38 (TP-38) In Pediatric Patients With Recurrent Or Progressive Supratentorial High Grade Gliomas Terminated NCT00074334 Phase 1, Phase 2
20 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
21 Phase I Trial Of Escalating Oral Doses Of SCH 66336 In Pediatric Patients With Refractory Or Recurrent Brain Tumors Completed NCT00015899 Phase 1 lonafarnib
22 Phase I Study of Intrathecal Spartaject-Busulfan in Children With Neoplastic Meningitis Completed NCT00006246 Phase 1 busulfan
23 A Trial of 06-BG and BCNU in Children With CNS Tumors Completed NCT00003765 Phase 1 O6-benzylguanine;carmustine
24 Phase I and Pharmacokinetic Trial of PTC299 in Pediatric Patients With Refractory or Recurrent CNS Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
25 A Phase I Study of Temozolomide, Oral Irinotecan, and Vincristine for Children With Refractory Solid Tumors Completed NCT00138216 Phase 1 irinotecan hydrochloride;temozolomide;vincristine sulfate
26 Phase I Trial and Pharmacokinetic Study of ABT-751, an Orally Bioavailable Tubulin Binding Agent, on a 7 Day and 21 Day Dosing Schedule in Pediatric Patients With Refractory Solid Tumors Completed NCT00036959 Phase 1 ABT-751
27 Phase I Trial and Pharmacokinetic Study of Temozolomide and O6-Benzylguanine in Childhood Solid Tumors Completed NCT00020150 Phase 1 O6-benzylguanine;temozolomide
28 Phase I Study of Doxorubicin HCl Liposome in Pediatric Patients With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
29 A Phase I Dose Escalation Study of Intravenous DX-8951f Administered Daily for Five Days Every Three Weeks to Pediatric Patients With Advanced Solid Tumors and Lymphomas Completed NCT00004212 Phase 1 exatecan mesylate
30 Phase I Trial and Pharmacokinetic Study of BMS-247550 (NSC 710428, Ixabepilone), an Epothilone B Analog, in Pediatric Patients With Refractory Solid Tumors and Leukemias Completed NCT00030108 Phase 1 ixabepilone
31 TREATMENT OF CHILDREN AND YOUNG ADULTS WITH RECURRENT/REFRACTORY SOLID TUMORS WITH HIGH DOSE ETOPOSIDE AND CARBOPLATIN PLUS ESCALATING DOSE CYCLOPHOSPHAMIDE, FOLLOWED BY HEMATOPOIETIC RESCUE USING AUTOLOGOUS CD34+ SELECTED BLOOD STEM CELLS: A PILOT STUDY Completed NCT00007813 Phase 1 carboplatin;cyclophosphamide;etoposide
32 A Phase I Study Of Vaccination With Telomerase Peptide Plus GM-CSF Completed NCT00069940 Phase 1
33 Phase I Dose Escalation Study of Autologous Tumor Lysate-Pulsed Dendritic Cell Immunotherapy for Malignant Gliomas in Pediatric Patients Completed NCT00107185 Phase 1
34 A Phase I Study of Vinblastine in Combination With Carboplatin for Children With Newly Diagnosed and Recurrent Low-Grade Gliomas Completed NCT00352495 Phase 1 carboplatin;vinblastine sulfate
35 Phase I and Pharmacokinetic Study of Enzastaurin (LY317615) in Children and Adolescents With Refractory Primary CNS Tumors Completed NCT00503724 Phase 1 enzastaurin hydrochloride
36 A Pilot Study of Dose-Intensified Procarbazine, CCNU, Vincristine (PCV) for Poor Prognosis Pediatric and Adult Brain Tumors Utilizing Fibronectin-Assisted, Retroviral-Mediated Modification of CD34+ Peripheral Blood Cells With O6-Methylguanine DNA Methyltransferase Completed NCT00005796 Phase 1 lomustine;procarbazine hydrochloride;vincristine sulfate
37 A Phase I Trial and Pharmacokinetic Study of Talabostat (PT-100, Val-Boro-Pro) in Combination With Temozolomide or Carboplatin in Pediatric Patients With Relapsed or Refractory Solid Tumors Including Brain Tumors Completed NCT00303940 Phase 1 carboplatin;talabostat mesylate;temozolomide
38 A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children With Refractory or Recurrent Solid Tumors and Lymphomas Completed NCT01273090 Phase 1 imetelstat sodium
39 A Phase I Study of SU5416 in Pediatric Patients With Recurrent or Progressive Poor Prognosis Brain Tumors Terminated NCT00006247 Phase 1 semaxanib
40 Phase I Dose Escalation Study of N-Acetylcysteine Administered in Conjunction With Carboplatin, Cyclophosphamide, and Etoposide Phosphate BBBD, in Children With Malignant Brain Tumors Terminated NCT00238173 Phase 1 acetylcysteine;carboplatin;cyclophosphamide;etoposide phosphate;mannitol;sodium thiosulfate
41 A Phase I Study of MK-0752 in Pediatric Patients With Recurrent or Refractory CNS Malignancies Terminated NCT00572182 Phase 1 MK-0752
42 A Phase I Pharmacokinetic Optimal Dosing Study of Intraventricular Topotecan for Children With Neoplastic Meningitis Terminated NCT00112619 Phase 1 topotecan hydrochloride
43 Efficacy of Gelclairâ„¢ in Reducing the Pain of Oral Mucositis in Children and Young People With Cancer (SC 2005 07) Unknown status NCT00349024 polyvinylpyrrolidone-sodium hyaluronate gel
44 Translation Study for Children and Adolescents With Low Grade Glioma Unknown status NCT00891722
45 A Pilot Study Using Carboplatin, Vincristine And Temozolomide For Children ≤ 10 Years With Progressive/Symptomatic Low-Grade Gliomas Completed NCT00077207 carboplatin;temozolomide;vincristine sulfate
46 Metabolic Syndrome in Childhood Cancer Survivors Completed NCT00920738
47 Barriers to Patient Enrollment Onto Frontline Therapeutic Clinical Trials and Development of Intervention Strategies to Increase the Proportion of Enrollment Completed NCT00002485
48 Diagnostic and Prognostic Markers in Low-Grade Gliomas Completed NCT01004523
49 A Pharmacokinetic Participation Questionnaire Study Completed NCT00890435
50 Cooperative Multicenter Study for Children and Adolescents With Low Grade Glioma Completed NCT00276640 vincristine, carboplatin;vincristine, carboplatin, etoposide

Search NIH Clinical Center for Childhood Oligodendroglioma

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Genetic Tests for Childhood Oligodendroglioma

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Anatomical Context for Childhood Oligodendroglioma

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MalaCards organs/tissues related to Childhood Oligodendroglioma:

40
Brain, Bone, Spinal Cord, Breast, Cerebellum, Liver, Colon
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Publications for Childhood Oligodendroglioma

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Articles related to Childhood Oligodendroglioma:

# Title Authors PMID Year
1
Predictors of clinical outcome in pediatric oligodendroglioma: meta-analysis of individual patient data and multiple imputation. 61
29192869 2018
2
Outcomes and Prognostic Factors in Pediatric Oligodendroglioma: A Population-Based Study. 61
29131101 2018
3
Molecular Analysis of Pediatric Oligodendrogliomas Highlights Genetic Differences with Adult Counterparts and Other Pediatric Gliomas. 61
26206478 2016
4
Conventional and advanced (DTI/SWI) neuroimaging findings in pediatric oligodendroglioma. 61
25813856 2015
5
Well-differentiated pediatric glial neoplasms with features of oligodendroglioma, angiocentric glioma and dysembryoplastic neuroepithelial tumors: a morphological diagnostic challenge. 61
24448703 2014
6
Homozygous deletion of TNFRSF4, TP73, PPAP2B and DPYD at 1p and PDCD5 at 19q identified by multiplex ligation-dependent probe amplification (MLPA) analysis in pediatric anaplastic glioma with questionable oligodendroglial component. 61
24387276 2014
7
Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. 61
22941225 2012
8
Assessment of 1p/19q status by fluorescence in situ hybridization assay: A comparative study in oligodendroglial, mixed oligoastrocytic and astrocytic tumors. 61
19934553 2009
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Variations for Childhood Oligodendroglioma

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Expression for Childhood Oligodendroglioma

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Search GEO for disease gene expression data for Childhood Oligodendroglioma.
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Pathways for Childhood Oligodendroglioma

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Pathways related to Childhood Oligodendroglioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Type I Interferon Signaling Pathways 64
Show member pathways
 11.88 H3C10 H3-3B H3-3A
2
Transcriptional misregulation in cancer 36
11.77 H3C10 H3-3B H3-3A
3
Factors involved in megakaryocyte development and platelet production 65
11.63 H3C10 H3-3B H3-3A
4
UVA-Induced MAPK Signaling 63
Show member pathways
 11.43 H3C10 H3-3B H3-3A
5
PKMTs methylate histone lysines 65
Show member pathways
 11.28 H3C10 H3-3B H3-3A
6
Cell cycle_Chromosome condensation in prometaphase 22
10.89 H3-3B H3-3A
7
Cytosine methylation 1
Show member pathways
 9.74 IDH2 IDH1
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GO Terms for Childhood Oligodendroglioma

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Cellular components related to Childhood Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 10.02 MGMT H3C10 H3-3B H3-3A FUBP1 FAM131B
2 nuclear chromosome, telomeric region GO:0000784 9.58 H3-3B H3-3A ATRX
3 chromosome GO:0005694 9.55 H3C10 H3-3B H3-3A CENPM ATRX
4 nucleosome GO:0000786 9.5 H3C10 H3-3B H3-3A
5 Barr body GO:0001740 9.26 H3-3B H3-3A
6 nuclear nucleosome GO:0000788 9.13 H3C10 H3-3B H3-3A
7 nuclear chromosome GO:0000228 8.92 H3C10 H3-3B H3-3A ATRX

Biological processes related to Childhood Oligodendroglioma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.77 H3C10 H3-3B H3-3A
2 multicellular organism growth GO:0035264 9.72 H3-3B H3-3A ATRX
3 regulation of gene silencing by miRNA GO:0060964 9.7 H3C10 H3-3B H3-3A
4 regulation of megakaryocyte differentiation GO:0045652 9.69 H3C10 H3-3B H3-3A
5 negative regulation of gene expression, epigenetic GO:0045814 9.65 H3C10 H3-3B H3-3A
6 nucleus organization GO:0006997 9.58 H3-3B H3-3A
7 DNA methylation GO:0006306 9.58 MGMT ATRX
8 chromatin silencing at rDNA GO:0000183 9.58 H3C10 H3-3B H3-3A
9 muscle cell differentiation GO:0042692 9.57 H3-3B H3-3A
10 2-oxoglutarate metabolic process GO:0006103 9.56 IDH2 IDH1
11 NADP metabolic process GO:0006739 9.54 IDH2 IDH1
12 isocitrate metabolic process GO:0006102 9.49 IDH2 IDH1
13 pericentric heterochromatin assembly GO:0031508 9.46 H3-3B H3-3A
14 regulation of centromere complex assembly GO:0090230 9.43 H3-3B H3-3A
15 negative regulation of chromosome condensation GO:1902340 9.37 H3-3B H3-3A
16 telomere organization GO:0032200 9.33 H3C10 H3-3B H3-3A
17 telomeric heterochromatin assembly GO:0031509 9.32 H3-3B H3-3A
18 glyoxylate cycle GO:0006097 9.26 IDH2 IDH1
19 nucleosome assembly GO:0006334 9.26 H3C10 H3-3B H3-3A ATRX
20 DNA replication-independent nucleosome assembly GO:0006336 8.8 H3-3B H3-3A ATRX

Molecular functions related to Childhood Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.7 OLIG2 MGMT H3C10 H3-3B H3-3A FUBP1
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.32 H3-3B H3-3A
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 IDH2 IDH1
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1
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Sources for Childhood Oligodendroglioma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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