MCID: CHL078
MIFTS: 29

Childhood-Onset Schizophrenia

Categories: Rare diseases

Aliases & Classifications for Childhood-Onset Schizophrenia

MalaCards integrated aliases for Childhood-Onset Schizophrenia:

Name: Childhood-Onset Schizophrenia 20 29 6
Schizophrenia, Childhood 70
Childhood Schizophrenia 20

Classifications:



External Ids:

UMLS 70 C0036346

Summaries for Childhood-Onset Schizophrenia

MalaCards based summary : Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to schizophrenia and landau-kleffner syndrome. An important gene associated with Childhood-Onset Schizophrenia is RYR2 (Ryanodine Receptor 2). The drugs Olanzapine and Clozapine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and temporal lobe.

Wikipedia : 73 Childhood schizophrenia (also known as childhood-onset schizophrenia, and very early-onset... more...

Related Diseases for Childhood-Onset Schizophrenia

Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 28.9 TTBK1 RYR2 GPR153 FREM2 B3GNT6 ARL16
2 landau-kleffner syndrome 11.0
3 early-onset schizophrenia 10.6
4 attention deficit-hyperactivity disorder 10.4
5 autism spectrum disorder 10.4
6 agenesis of corpus callosum, cardiac, ocular, and genital syndrome 10.3
7 psychotic disorder 10.3
8 autism 10.3
9 schizoaffective disorder 10.3
10 hand skill, relative 10.2
11 alacrima, achalasia, and mental retardation syndrome 10.2
12 pervasive developmental disorder 10.2
13 tardive dyskinesia 10.1
14 schizotypal personality disorder 10.1
15 personality disorder 10.1
16 mood disorder 10.1
17 mutism 10.1
18 schizophrenia 1 10.0
19 velocardiofacial syndrome 10.0
20 anxiety 10.0
21 major affective disorder 8 10.0
22 major affective disorder 9 10.0
23 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 10.0
24 speech and communication disorders 10.0
25 alternating hemiplegia of childhood 10.0
26 parkinsonism 10.0
27 hemiplegia 10.0
28 bipolar disorder 10.0
29 47,xyy 10.0
30 elective mutism 10.0
31 granulocytopenia 10.0
32 overgrowth syndrome 10.0
33 huntington disease 9.9
34 obsessive-compulsive disorder 9.9
35 schizophrenia 13 9.9
36 oppositional defiant disorder 9.9
37 hyperprolinemia 9.9
38 separation anxiety disorder 9.9
39 dysthymic disorder 9.9
40 neutropenia 9.9
41 conduct disorder 9.9
42 generalized anxiety disorder 9.9
43 tic disorder 9.9
44 central nervous system disease 9.9
45 dyslexia 9.9
46 movement disease 9.9
47 dystonia 9.9
48 learning disability 9.9
49 15q duplication syndrome and related disorders 9.9
50 atp1a3-related neurologic disorders 9.9

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to Childhood-Onset Schizophrenia

Symptoms & Phenotypes for Childhood-Onset Schizophrenia

Drugs & Therapeutics for Childhood-Onset Schizophrenia

Drugs for Childhood-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585 135398745
2
Clozapine Approved Phase 4 5786-21-0 2818
3 Neurotransmitter Agents Phase 4
4 Psychotropic Drugs Phase 4
5 Gastrointestinal Agents Phase 4
6 Antiemetics Phase 4
7 Serotonin Uptake Inhibitors Phase 4
8 Antipsychotic Agents Phase 4
9
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
10
Oxytocin Approved, Vet_approved Phase 1, Phase 2 50-56-6 53477758 439302

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Childhood Onset Psychotic Disorders: Characterization and Treatment With Atypical Neuroleptics Completed NCT00001656 Phase 4 Olanzapine;Clozapine
2 Treating Refractory Childhood Schizophrenia Completed NCT00048828 Phase 4 Olanzapine;Clozapine
3 The Use of Daily, Intranasal Oxytocin for the Treatment of Childhood-Onset Schizophrenia (COS), a Randomized Double-Blind Trial Terminated NCT01712646 Phase 1, Phase 2 Intranasal Oxytocin
4 Safety of Transcranial Direct Current Brain Stimulation (TDCS) for Improvement of Psychotic Symptoms and Cognitive Functioning in Childhood Onset Schizophrenia (COS) Terminated NCT00757497 Phase 1
5 Enhancing Evidence-Based Practice for Youth and Emerging Adults With Early Psychosis: Implementation and Evaluation in Diverse Service Settings Recruiting NCT03919760

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

Genetic tests related to Childhood-Onset Schizophrenia:

# Genetic test Affiliating Genes
1 Childhood-Onset Schizophrenia 29

Anatomical Context for Childhood-Onset Schizophrenia

MalaCards organs/tissues related to Childhood-Onset Schizophrenia:

40
Eye, Brain, Temporal Lobe, Cortex, Cerebellum

Publications for Childhood-Onset Schizophrenia

Articles related to Childhood-Onset Schizophrenia:

(show top 50) (show all 358)
# Title Authors PMID Year
1
De novo variants in sporadic cases of childhood onset schizophrenia. 6 61
26508570 2016
2
Sleep neurophysiology in childhood onset schizophrenia. 61
32350968 2021
3
Functional outcomes and patient satisfaction following inpatient treatment for childhood-onset schizophrenia spectrum disorders vs non-psychotic disorders in children in the United Kingdom. 61
32431095 2021
4
Expansion of the GRIA2 phenotypic representation: a novel de novo loss of function mutation in a case with childhood onset schizophrenia. 61
32948840 2021
5
A novel microduplication in INPP5A segregates with schizophrenia spectrum disorder in the family of a patient with both childhood onset schizophrenia and autism spectrum disorder. 61
33720513 2021
6
Atteintes Neurodéveloppementales, Comorbidités Psychiatriques Et Pathologies Associées Chez Des Patients Atteints de Schizophrénie Très Précoce Avec Symptômes Autistiques Prémorbides.: Neurodevelopmental Disorders, Psychiatric Comorbidities and Associated Pathologies in Patients with Childhood-Onset Schizophrenia and Premorbid Autistic Symptoms. 61
33563032 2021
7
Comparison of clinical characteristics and treatment efficacy in childhood-onset schizophrenia and adolescent-onset schizophrenia in mainland China: A retrospective study. 61
33465837 2021
8
Predictive factors in early onset schizophrenia. 61
33149774 2020
9
Sleep spindle activity in childhood onset schizophrenia: Diminished and associated with clinical symptoms. 61
32980206 2020
10
Sex differences in circulating neuregulin1-β1 and β-secretase 1 expression in childhood-onset schizophrenia. 61
32430144 2020
11
Evidence of shared familial factors influencing neurocognitive endophenotypes in adult- and childhood-onset schizophrenia. 61
31362798 2020
12
Co-Occurrence of Autistic Spectrum Disorder and Childhood-Onset Schizophrenia. 61
32470234 2020
13
Missense variants in ATP1A3 and FXYD gene family are associated with childhood-onset schizophrenia. 61
29895895 2020
14
Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update. 61
31708054 2020
15
Genetics of Childhood-onset Schizophrenia 2019 Update. 61
31708045 2020
16
Chromatin remodeling dysfunction extends the etiological spectrum of schizophrenia: a case report. 61
31914951 2020
17
Whatever happened to multiple complex developmental disorder? 61
33061748 2020
18
Effects of ketamine on prepubertal Wistar rats: Implications on behavioral parameters for Childhood-Onset Schizophrenia. 61
31678549 2019
19
Age Matters: an Atypical Association Between Polymorphism of MTHFR and Clinical Phenotypes in Children with Schizophrenia. 61
31302825 2019
20
Increased prevalence of psychopathy and childhood trauma in homicide offenders with schizophrenia compared to nonviolent individuals with schizophrenia. 61
31443617 2019
21
Case Report of Childhood-Onset Psychosis in a Patient with a Known WNT10A Mutation. 61
31798653 2019
22
Exome sequencing of sporadic childhood-onset schizophrenia suggests the contribution of X-linked genes in males. 61
30378261 2019
23
Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling. 61
31242417 2019
24
Complexity in Evaluation and Pharmacological Treatment of Early Onset Psychosis with Mood Symptoms: Childhood Onset Schizophrenia or Affective Disorder? 61
30946619 2019
25
Childhood Trauma in Schizophrenia: Current Findings and Research Perspectives. 61
30983960 2019
26
Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study. 61
30697262 2019
27
Childhood-Onset Schizophrenia: A Systematic Overview of Its Genetic Heterogeneity From Classical Studies to the Genomic Era. 61
31921276 2019
28
7 T MRI reveals hippocampal structural abnormalities associated with memory intrusions in childhood-onset schizophrenia. 61
30029830 2018
29
Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells. 61
30513688 2018
30
Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples. 61
29567402 2018
31
The effects of antipsychotics on the density of cannabinoid receptors in selected brain regions of male and female adolescent juvenile rats. 61
29576413 2018
32
Attenuated resting-state functional connectivity in patients with childhood- and adult-onset schizophrenia. 61
29310911 2018
33
Symptom dimensions and subgroups in childhood-onset schizophrenia. 61
29146021 2018
34
Adults With Childhood-Onset Schizophrenia and Their Siblings: Do Age of Onset and Familiality Affect Performance on and the Neural Signature of Working Memory Tasks? 61
29496120 2018
35
Reduced Functional Brain Activation and Connectivity During a Working Memory Task in Childhood-Onset Schizophrenia. 61
29496125 2018
36
An overview of medical risk factors for childhood psychosis: Implications for research and treatment. 61
28526280 2018
37
Childhood cognitive development in 22q11.2 deletion syndrome: case-control study. 61
28882829 2017
38
Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders. 61
27834153 2017
39
DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia. 61
27829189 2016
40
Childhood maltreatment increases the risk of suicide attempt in schizophrenia. 61
27236409 2016
41
Transcranial direct current stimulation in children and adolescents: a comprehensive review. 61
27173384 2016
42
A novel de novo mutation in ATP1A3 and childhood-onset schizophrenia. 61
27626066 2016
43
15q13.3 duplication in two patients with childhood-onset schizophrenia. 61
26968334 2016
44
Transcranial Direct Current Stimulation in Child and Adolescent Psychiatry. 61
27027666 2016
45
Lack of Gender-Related Differences in Childhood-Onset Schizophrenia. 61
27566120 2016
46
Challenges and Promises of Pediatric Psychopharmacology. 61
27064142 2016
47
A Review of Childhood-Onset Schizophrenia. 61
31975813 2016
48
Strong Treatment Response and High Maintenance Rates of Clozapine in Childhood-Onset Schizophrenia. 61
26784704 2016
49
Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings. 61
25819937 2016
50
Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms. 61
26802780 2016

Variations for Childhood-Onset Schizophrenia

ClinVar genetic disease variations for Childhood-Onset Schizophrenia:

6 (show all 21)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 GTF2IRD1 NM_005685.4(GTF2IRD1):c.973C>T (p.Arg325Cys) SNV Likely pathogenic 208388 rs863223350 GRCh37: 7:73935594-73935594
GRCh38: 7:74521264-74521264
2 NLRP12 NM_001277126.1(NLRP12):c.858C>G (p.Pro286=) SNV Likely pathogenic 208384 rs145171629 GRCh37: 19:54314055-54314055
GRCh38: 19:53810801-53810801
3 PDZRN3 NM_015009.3(PDZRN3):c.820G>A (p.Asp274Asn) SNV Likely pathogenic 208395 rs748809996 GRCh37: 3:73651603-73651603
GRCh38: 3:73602452-73602452
4 GPR153 NM_207370.4(GPR153):c.217C>T (p.Arg73Cys) SNV Likely pathogenic 208391 rs776061422 GRCh37: 1:6314749-6314749
GRCh38: 1:6254689-6254689
5 TTBK1 NM_032538.3(TTBK1):c.773G>A (p.Arg258Gln) SNV Likely pathogenic 208398 rs759748655 GRCh37: 6:43223506-43223506
GRCh38: 6:43255768-43255768
6 PTGIS NM_000961.4(PTGIS):c.824G>A (p.Arg275Gln) SNV Likely pathogenic 208402 rs61734270 GRCh37: 20:48140626-48140626
GRCh38: 20:49524089-49524089
7 POC1B , POC1B-GALNT4 , GALNT4 NM_003774.5(GALNT4):c.1194C>T (p.Asn398=) SNV Likely pathogenic 208386 rs863223348 GRCh37: 12:89917133-89917133
GRCh38: 12:89523356-89523356
8 RYR2 NM_001035.3(RYR2):c.2236C>T (p.Gln746Ter) SNV Likely pathogenic 208396 rs863223354 GRCh37: 1:237664043-237664043
GRCh38: 1:237500743-237500743
9 B3GNT6 NM_138706.5(B3GNT6):c.552C>G (p.Asp184Glu) SNV Likely pathogenic 208399 rs781821239 GRCh37: 11:76751147-76751147
GRCh38: 11:77040103-77040103
10 SEZ6 NM_178860.5(SEZ6):c.678_686del (p.Thr227_Thr229del) Deletion Likely pathogenic 208383 rs863223347 GRCh37: 17:27308427-27308435
GRCh38: 17:28981409-28981417
11 ITGA6 NM_001079818.3(ITGA6):c.3183_3185AGA[1] (p.Glu1063del) Microsatellite Likely pathogenic 208387 rs863223349 GRCh37: 2:173368886-173368888
GRCh38: 2:172504158-172504160
12 RELA NM_021975.4(RELA):c.329T>C (p.Ile110Thr) SNV Likely pathogenic 208401 rs863223356 GRCh37: 11:65429164-65429164
GRCh38: 11:65661693-65661693
13 ARL16 , LOC112533681 NM_001040025.2(ARL16):c.32G>T (p.Arg11Leu) SNV Likely pathogenic 208393 rs863223352 GRCh37: 17:79650824-79650824
GRCh38: 17:81683794-81683794
14 HSPG2 NM_005529.7(HSPG2):c.4233C>T (p.Tyr1411=) SNV Likely pathogenic 208389 rs745452577 GRCh37: 1:22192291-22192291
GRCh38: 1:21865798-21865798
15 MEST NM_002402.4(MEST):c.559C>T (p.Pro187Ser) SNV Likely pathogenic 208394 rs863223353 GRCh37: 7:130139739-130139739
GRCh38: 7:130499898-130499898
16 FREM2 NM_207361.6(FREM2):c.8351G>A (p.Arg2784Lys) SNV Likely pathogenic 208382 rs863223346 GRCh37: 13:39450228-39450228
GRCh38: 13:38876091-38876091
17 STAC2 NM_198993.5(STAC2):c.257G>A (p.Arg86Lys) SNV Likely pathogenic 208390 rs863223351 GRCh37: 17:37374260-37374260
GRCh38: 17:39218007-39218007
18 RYR2 NM_001035.3(RYR2):c.2238A>C (p.Gln746His) SNV Likely pathogenic 208397 rs863223355 GRCh37: 1:237664045-237664045
GRCh38: 1:237500745-237500745
19 PLXNA3 NM_017514.5(PLXNA3):c.1847G>A (p.Arg616Gln) SNV Benign 208405 rs200042650 GRCh37: X:153692763-153692763
GRCh38: X:154464420-154464420
20 LOC110121499 , PISD NM_001326411.1(PISD):c.322-3886G>A SNV Benign 208404 rs863223357 GRCh37: 22:32021757-32021757
GRCh38: 22:31625771-31625771
21 PPP1R13B NM_015316.3(PPP1R13B):c.215G>A (p.Arg72Gln) SNV Benign 208406 rs863223358 GRCh37: 14:104251194-104251194
GRCh38: 14:103784857-103784857

Expression for Childhood-Onset Schizophrenia

Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for Childhood-Onset Schizophrenia

GO Terms for Childhood-Onset Schizophrenia

Sources for Childhood-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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