MCID: CHL078
MIFTS: 33

Childhood-Onset Schizophrenia

Categories: Rare diseases

Aliases & Classifications for Childhood-Onset Schizophrenia

MalaCards integrated aliases for Childhood-Onset Schizophrenia:

Name: Childhood-Onset Schizophrenia 53 29 6
Schizophrenia, Childhood 73
Childhood Schizophrenia 53

Classifications:



External Ids:

UMLS 73 C0036346

Summaries for Childhood-Onset Schizophrenia

MalaCards based summary : Childhood-Onset Schizophrenia, also known as schizophrenia, childhood, is related to schizophrenia and landau-kleffner syndrome. An important gene associated with Childhood-Onset Schizophrenia is RYR2 (Ryanodine Receptor 2), and among its related pathways/superpathways is Dilated cardiomyopathy (DCM). The drugs Clozapine and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and eye, and related phenotype is Increased transferrin (TF) endocytosis.

Wikipedia : 76 Childhood schizophrenia (also known as childhood-onset schizophrenia, and very early-onset... more...

Related Diseases for Childhood-Onset Schizophrenia

Diseases related to Childhood-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 10.9
2 landau-kleffner syndrome 10.9
3 autism 10.2
4 attention deficit-hyperactivity disorder 10.1
5 autism spectrum disorder 10.0
6 depression 9.9
7 velocardiofacial syndrome 9.8
8 tardive dyskinesia 9.8
9 cognitive function 1, social 9.8
10 aging 9.8
11 alacrima, achalasia, and mental retardation syndrome 9.8
12 neutropenia 9.8
13 pervasive developmental disorder 9.8
14 schizotypal personality disorder 9.8
15 personality disorder 9.8
16 psychotic disorder 9.8
17 tic disorder 9.8
18 mood disorder 9.8
19 cerebritis 9.8
20 mutism 9.8
21 movement disease 9.8
22 neuronitis 9.8
23 hyperprolinemia 9.8
24 early-onset schizophrenia 9.8

Graphical network of the top 20 diseases related to Childhood-Onset Schizophrenia:



Diseases related to Childhood-Onset Schizophrenia

Symptoms & Phenotypes for Childhood-Onset Schizophrenia

GenomeRNAi Phenotypes related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.02 ITGA6 MEST NLRP12 PLXNA3 PTGIS

Drugs & Therapeutics for Childhood-Onset Schizophrenia

Drugs for Childhood-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clozapine Approved Phase 4 5786-21-0 2818
2
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
3 Central Nervous System Depressants Phase 4
4 GABA Agents Phase 4
5 Serotonin Agents Phase 4
6 Serotonin Antagonists Phase 4
7 Serotonin Uptake Inhibitors Phase 4
8 Gastrointestinal Agents Phase 4
9 Neurotransmitter Agents Phase 4
10 Neurotransmitter Uptake Inhibitors Phase 4
11 Tranquilizing Agents Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Antiemetics Phase 4
14 Antipsychotic Agents Phase 4
15 Psychotropic Drugs Phase 4
16 Autonomic Agents Phase 4
17
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
18 Rho(D) Immune Globulin Phase 3
19 gamma-Globulins Phase 3
20 Antibodies Phase 3
21 Immunoglobulins Phase 3
22 Immunoglobulins, Intravenous Phase 3
23
Oxytocin Approved, Vet_approved Phase 1, Phase 2 50-56-6 439302 53477758
24 Oxytocics Phase 1, Phase 2
25
Epinephrine Approved, Vet_approved 51-43-4 5816
26
Racepinephrine Approved 329-65-7 838
27 Epinephryl borate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treating Drug-Resistant Childhood Schizophrenia Completed NCT00048828 Phase 4 Olanzapine;Clozapine
2 Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders Completed NCT00001656 Phase 4 Olanzapine;Clozapine
3 Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg) Completed NCT00001768 Phase 3 Intravenous immunoglobulin
4 Daily Intranasal Oxytocin for Childhood-Onset Schizophrenia Terminated NCT01712646 Phase 1, Phase 2 Intranasal Oxytocin
5 Transcranial Direct Current Brain Stimulation to Treat Patients With Childhood-Onset Schizophrenia Terminated NCT00757497 Phase 1
6 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
7 Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers Recruiting NCT00001246
8 Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia Terminated NCT00001198
9 Screening for Childhood-Onset Psychotic Disorders Terminated NCT00049738

Search NIH Clinical Center for Childhood-Onset Schizophrenia

Genetic Tests for Childhood-Onset Schizophrenia

Genetic tests related to Childhood-Onset Schizophrenia:

# Genetic test Affiliating Genes
1 Childhood-Onset Schizophrenia 29

Anatomical Context for Childhood-Onset Schizophrenia

MalaCards organs/tissues related to Childhood-Onset Schizophrenia:

41
Brain, Temporal Lobe, Eye, Testes, Cortex, Cerebellum

Publications for Childhood-Onset Schizophrenia

Articles related to Childhood-Onset Schizophrenia:

(show top 50) (show all 185)
# Title Authors Year
1
Reduced Functional Brain Activation and Connectivity During a Working Memory Task in Childhood-Onset Schizophrenia. ( 29496125 )
2018
2
Missense variants in ATP1A3 and FXYD gene family are associated with childhood-onset schizophrenia. ( 29895895 )
2018
3
Adults With Childhood-Onset Schizophrenia and Their Siblings: Do Age of Onset and Familiality Affect Performance on and the Neural Signature of Working Memory Tasks? ( 29496120 )
2018
4
Symptom dimensions and subgroups in childhood-onset schizophrenia. ( 29146021 )
2017
5
Strong Treatment Response and High Maintenance Rates of Clozapine in Childhood-Onset Schizophrenia. ( 26784704 )
2016
6
Lack of Gender-Related Differences in Childhood-Onset Schizophrenia. ( 27566120 )
2016
7
Altered intra- and inter-network dynamics reflect symptom dimensions in childhood-onset schizophrenia. ( 26747855 )
2016
8
A novel de novo mutation in ATP1A3 and childhood-onset schizophrenia. ( 27626066 )
2016
9
15q13.3 duplication in two patients with childhood-onset schizophrenia. ( 26968334 )
2016
10
DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia. ( 27829189 )
2016
11
Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings. ( 25819937 )
2015
12
Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia. ( 26493637 )
2015
13
De novo variants in sporadic cases of childhood onset schizophrenia. ( 26508570 )
2015
14
Functional and clinical insights from neuroimaging studies in childhood-onset schizophrenia. ( 26234702 )
2015
15
Hippocampal volume change relates to clinical outcome in childhood-onset schizophrenia. ( 25936396 )
2015
16
Cognitive correlates of gray matter abnormalities in adolescent siblings of patients with childhood-onset schizophrenia. ( 25541139 )
2015
17
Childhood-onset schizophrenia case with 2.2A Mb deletion at chromosome 3p12.2-p12.1 and two large chromosomal abnormalities at 16q22.3-q24.3 and Xq23-q28. ( 25914809 )
2015
18
Childhood-onset schizophrenia: what do we really know? ( 25750815 )
2014
19
Comparing Fractional Anisotropy in Patients With Childhood-Onset Schizophrenia, Their Healthy Siblings, and Normal Volunteers Through DTI. ( 25217482 )
2014
20
Looking for childhood-onset schizophrenia: diagnostic algorithms for classifying children and adolescents with psychosis. ( 25019955 )
2014
21
Common polygenic variation and risk for childhood-onset schizophrenia. ( 25510512 )
2014
22
Reality Testing in Children with Childhood-Onset Schizophrenia and Normal Children: A Comparison using the Ego Impairment Index on the Rorschach. ( 23682251 )
2013
23
Unremitting impulsive aggression in a child with childhood onset schizophrenia and pervasive development disorder-not otherwise specified: the role of stimulants, atypical antipsychotics and mood stabilizers. ( 23782130 )
2013
24
Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. ( 23622854 )
2013
25
At the boundary of the self: The insular cortex in patients with childhood-onset schizophrenia, their healthy siblings, and normal volunteers. ( 23770018 )
2013
26
Childhood onset schizophrenia and early onset schizophrenia spectrum disorders. ( 24012072 )
2013
27
Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia. ( 21613381 )
2013
28
Evidence for Corticostriatal Dysfunction During Cognitive Skill Learning in Adolescent Siblings of Patients With Childhood-Onset Schizophrenia. ( 24162516 )
2013
29
High circulatory titer of platelet-associated autoantibodies in childhood onset schizophrenia and its diagnostic implications. ( 23881299 )
2013
30
Genetics of childhood-onset schizophrenia. ( 24012080 )
2013
31
Absence of anatomic corpus callosal abnormalities in childhood-onset schizophrenia patients and healthy siblings. ( 23154096 )
2013
32
Aspirin as an adjunctive treatment for childhood onset schizophrenia. ( 24138014 )
2013
33
A Comparison of Neuroimaging Findings in Childhood Onset Schizophrenia and Autism Spectrum Disorder: A Review of the Literature. ( 24391605 )
2013
34
High rate of disease-related copy number variations in childhood onset schizophrenia. ( 23689535 )
2013
35
Violence in childhood-onset schizophrenia. ( 25478126 )
2013
36
The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth. ( 23821644 )
2013
37
Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia. ( 23510445 )
2013
38
[Childhood-onset schizophrenia]. ( 23678603 )
2013
39
White matter integrity, language, and childhood onset schizophrenia. ( 22405729 )
2012
40
Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls. ( 22675310 )
2012
41
Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. ( 22214315 )
2012
42
A case report on the relationship between treatment-resistant childhood-onset schizophrenia and an abnormally enlarged cavum septum pellucidum combined with cavum vergae. ( 22613614 )
2012
43
17 years of treatment-resistant mutism in non-catatonic, childhood-onset schizophrenia: a rare case report. ( 22450644 )
2012
44
Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophrenia. ( 22945617 )
2012
45
Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. ( 21245087 )
2011
46
A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders. ( 20479756 )
2011
47
Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls. ( 21620981 )
2011
48
Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder. ( 20955775 )
2011
49
Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia. ( 22032743 )
2011
50
Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia. ( 21703497 )
2011

Variations for Childhood-Onset Schizophrenia

ClinVar genetic disease variations for Childhood-Onset Schizophrenia:

6
(show all 42)
# Gene Variation Type Significance SNP ID Assembly Location
1 HSPG2 NM_005529.6(HSPG2): c.4233C> T (p.Tyr1411=) single nucleotide variant Conflicting interpretations of pathogenicity rs745452577 GRCh37 Chromosome 1, 22192291: 22192291
2 HSPG2 NM_005529.6(HSPG2): c.4233C> T (p.Tyr1411=) single nucleotide variant Conflicting interpretations of pathogenicity rs745452577 GRCh38 Chromosome 1, 21865798: 21865798
3 RYR2 NM_001035.2(RYR2): c.2236C> T (p.Gln746Ter) single nucleotide variant Likely pathogenic rs863223354 GRCh37 Chromosome 1, 237664043: 237664043
4 RYR2 NM_001035.2(RYR2): c.2236C> T (p.Gln746Ter) single nucleotide variant Likely pathogenic rs863223354 GRCh38 Chromosome 1, 237500743: 237500743
5 RYR2 NM_001035.2(RYR2): c.2238A> C (p.Gln746His) single nucleotide variant Likely pathogenic rs863223355 GRCh37 Chromosome 1, 237664045: 237664045
6 RYR2 NM_001035.2(RYR2): c.2238A> C (p.Gln746His) single nucleotide variant Likely pathogenic rs863223355 GRCh38 Chromosome 1, 237500745: 237500745
7 GPR153 NM_207370.3(GPR153): c.217C> T (p.Arg73Cys) single nucleotide variant Likely pathogenic rs776061422 GRCh37 Chromosome 1, 6314749: 6314749
8 GPR153 NM_207370.3(GPR153): c.217C> T (p.Arg73Cys) single nucleotide variant Likely pathogenic rs776061422 GRCh38 Chromosome 1, 6254689: 6254689
9 ITGA6 NM_001079818.2(ITGA6): c.3186_3188delAGA (p.Glu1063del) deletion Likely pathogenic rs863223349 GRCh38 Chromosome 2, 172504162: 172504164
10 ITGA6 NM_001079818.2(ITGA6): c.3186_3188delAGA (p.Glu1063del) deletion Likely pathogenic rs863223349 GRCh37 Chromosome 2, 173368890: 173368892
11 PDZRN3 NM_015009.2(PDZRN3): c.820G> A (p.Asp274Asn) single nucleotide variant Likely pathogenic rs748809996 GRCh38 Chromosome 3, 73602452: 73602452
12 PDZRN3 NM_015009.2(PDZRN3): c.820G> A (p.Asp274Asn) single nucleotide variant Likely pathogenic rs748809996 GRCh37 Chromosome 3, 73651603: 73651603
13 TTBK1 NM_032538.2(TTBK1): c.773G> A (p.Arg258Gln) single nucleotide variant Likely pathogenic rs759748655 GRCh38 Chromosome 6, 43255768: 43255768
14 TTBK1 NM_032538.2(TTBK1): c.773G> A (p.Arg258Gln) single nucleotide variant Likely pathogenic rs759748655 GRCh37 Chromosome 6, 43223506: 43223506
15 MEST NM_177524.2(MEST): c.532C> T (p.Pro178Ser) single nucleotide variant Likely pathogenic rs863223353 GRCh37 Chromosome 7, 130139739: 130139739
16 MEST NM_177524.2(MEST): c.532C> T (p.Pro178Ser) single nucleotide variant Likely pathogenic rs863223353 GRCh38 Chromosome 7, 130499898: 130499898
17 GTF2IRD1 NM_001199207.1(GTF2IRD1): c.1069C> T (p.Arg357Cys) single nucleotide variant Likely pathogenic rs863223350 GRCh38 Chromosome 7, 74521264: 74521264
18 GTF2IRD1 NM_001199207.1(GTF2IRD1): c.1069C> T (p.Arg357Cys) single nucleotide variant Likely pathogenic rs863223350 GRCh37 Chromosome 7, 73935594: 73935594
19 RELA NM_021975.3(RELA): c.329T> C (p.Ile110Thr) single nucleotide variant Likely pathogenic rs863223356 GRCh38 Chromosome 11, 65661693: 65661693
20 RELA NM_021975.3(RELA): c.329T> C (p.Ile110Thr) single nucleotide variant Likely pathogenic rs863223356 GRCh37 Chromosome 11, 65429164: 65429164
21 B3GNT6 NM_138706.4(B3GNT6): c.552C> G (p.Asp184Glu) single nucleotide variant Likely pathogenic rs781821239 GRCh37 Chromosome 11, 76751147: 76751147
22 B3GNT6 NM_138706.4(B3GNT6): c.552C> G (p.Asp184Glu) single nucleotide variant Likely pathogenic rs781821239 GRCh38 Chromosome 11, 77040103: 77040103
23 GALNT4; POC1B; POC1B-GALNT4 NM_001199781.1(POC1B-GALNT4): c.1185C> T (p.Asn395=) single nucleotide variant Likely pathogenic rs863223348 GRCh38 Chromosome 12, 89523356: 89523356
24 GALNT4; POC1B; POC1B-GALNT4 NM_001199781.1(POC1B-GALNT4): c.1185C> T (p.Asn395=) single nucleotide variant Likely pathogenic rs863223348 GRCh37 Chromosome 12, 89917133: 89917133
25 FREM2 NM_207361.5(FREM2): c.8351G> A (p.Arg2784Lys) single nucleotide variant Likely pathogenic rs863223346 GRCh37 Chromosome 13, 39450228: 39450228
26 FREM2 NM_207361.5(FREM2): c.8351G> A (p.Arg2784Lys) single nucleotide variant Likely pathogenic rs863223346 GRCh38 Chromosome 13, 38876091: 38876091
27 PPP1R13B NM_015316.2(PPP1R13B): c.215G> A (p.Arg72Gln) single nucleotide variant Benign rs863223358 GRCh37 Chromosome 14, 104251194: 104251194
28 PPP1R13B NM_015316.2(PPP1R13B): c.215G> A (p.Arg72Gln) single nucleotide variant Benign rs863223358 GRCh38 Chromosome 14, 103784857: 103784857
29 SEZ6 NM_178860.4(SEZ6): c.678_686delTACCACCAC (p.Thr227_Thr229del) deletion Likely pathogenic rs863223347 GRCh38 Chromosome 17, 28981409: 28981417
30 SEZ6 NM_178860.4(SEZ6): c.678_686delTACCACCAC (p.Thr227_Thr229del) deletion Likely pathogenic rs863223347 GRCh37 Chromosome 17, 27308427: 27308435
31 STAC2 NM_198993.4(STAC2): c.257G> A (p.Arg86Lys) single nucleotide variant Likely pathogenic rs863223351 GRCh37 Chromosome 17, 37374260: 37374260
32 STAC2 NM_198993.4(STAC2): c.257G> A (p.Arg86Lys) single nucleotide variant Likely pathogenic rs863223351 GRCh38 Chromosome 17, 39218007: 39218007
33 ARL16 NM_001040025.2(ARL16): c.32G> T (p.Arg11Leu) single nucleotide variant Likely pathogenic rs863223352 GRCh38 Chromosome 17, 81683794: 81683794
34 ARL16 NM_001040025.2(ARL16): c.32G> T (p.Arg11Leu) single nucleotide variant Likely pathogenic rs863223352 GRCh37 Chromosome 17, 79650824: 79650824
35 NLRP12 NM_001277126.1(NLRP12): c.858C> G (p.Pro286=) single nucleotide variant Likely pathogenic rs145171629 GRCh38 Chromosome 19, 53810801: 53810801
36 NLRP12 NM_001277126.1(NLRP12): c.858C> G (p.Pro286=) single nucleotide variant Likely pathogenic rs145171629 GRCh37 Chromosome 19, 54314055: 54314055
37 PTGIS NM_000961.3(PTGIS): c.824G> A (p.Arg275Gln) single nucleotide variant Likely pathogenic rs61734270 GRCh37 Chromosome 20, 48140626: 48140626
38 PTGIS NM_000961.3(PTGIS): c.824G> A (p.Arg275Gln) single nucleotide variant Likely pathogenic rs61734270 GRCh38 Chromosome 20, 49524089: 49524089
39 PISD NM_014338.3(PISD): c.45G> A (p.Ala15=) single nucleotide variant Benign rs863223357 GRCh37 Chromosome 22, 32021757: 32021757
40 PISD NM_014338.3(PISD): c.45G> A (p.Ala15=) single nucleotide variant Benign rs863223357 GRCh38 Chromosome 22, 31625771: 31625771
41 PLXNA3 NM_017514.4(PLXNA3): c.1847G> A (p.Arg616Gln) single nucleotide variant Benign rs200042650 GRCh38 Chromosome X, 154464420: 154464420
42 PLXNA3 NM_017514.4(PLXNA3): c.1847G> A (p.Arg616Gln) single nucleotide variant Benign rs200042650 GRCh37 Chromosome X, 153692763: 153692763

Expression for Childhood-Onset Schizophrenia

Search GEO for disease gene expression data for Childhood-Onset Schizophrenia.

Pathways for Childhood-Onset Schizophrenia

Pathways related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.86 ITGA6 RYR2

GO Terms for Childhood-Onset Schizophrenia

Biological processes related to Childhood-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 8.96 NLRP12 PTGIS
2 negative regulation of NF-kappaB transcription factor activity GO:0032088 8.62 NLRP12 PTGIS

Sources for Childhood-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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