Childhood Pilocytic Astrocytoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Childhood Pilocytic Astrocytoma

MalaCards integrated aliases for Childhood Pilocytic Astrocytoma:

Name: Childhood Pilocytic Astrocytoma ¹² ¹⁵ ⁷³

Pediatric Pilocytic Astrocytoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6812

NCIt ⁵⁰ C4048

UMLS ⁷³ C1332995

Sources

Summaries for Childhood Pilocytic Astrocytoma

MalaCards based summary : Childhood Pilocytic Astrocytoma, also known as pediatric pilocytic astrocytoma, is related to astrocytoma and pilocytic astrocytoma, and has symptoms including headache An important gene associated with Childhood Pilocytic Astrocytoma is NTM (Neurotrimin), and among its related pathways/superpathways are Neuroscience and L1CAM interactions. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and nervous system

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Related Diseases for Childhood Pilocytic Astrocytoma

Diseases related to Childhood Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	astrocytoma	10.1
2	pilocytic astrocytoma	10.1
3	juvenile pilocytic astrocytoma	9.8	NF1 NTM

Sources

Symptoms & Phenotypes for Childhood Pilocytic Astrocytoma

UMLS symptoms related to Childhood Pilocytic Astrocytoma:

headache

MGI Mouse Phenotypes related to Childhood Pilocytic Astrocytoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.55	CNTNAP1 DOCK2 NF1 PBX3 SH3GL2
2	nervous system	MP:0003631	9.35	CNTNAP1 DOCK2 NF1 PBX3 SH3GL2
3	skeleton	MP:0005390	8.92	CNTNAP1 NF1 PBX3 SH3GL2

Sources

Drugs & Therapeutics for Childhood Pilocytic Astrocytoma

Drugs for Childhood Pilocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Histamine

Approved, Investigational

Phase 3

51-45-6, 75614-87-8

774

Synonyms:

.beta.-Imidazolyl-4-ethylamine

[3H]histamine

1avn

1H-Imidazole-4-ethanamine

1H-Imidazole-5-ethanamine

1qft

2-(1H-imidazol-4-yl)ethan-1-amine

2-(1H-Imidazol-4-yl)ethanamine

2-(1H-Imidazol-4-yl)ethylamine

2-(1H-imidazol-5-yl)ethanamine

2-(1H-Imidazol-5-yl)ethanamine

2-(1H-Imidazol-5-yl)ethylamine

2-(3H-Imidazol-4-yl)-ethylamine

2-(4-Imidazolyl)ethanamine

2-(4-imidazolyl)ethylamine

2-(4-Imidazolyl)ethylamine

2-[4-Imidazolyl]ethylamine

2-Imidazol-4-ylethylamine

2-Imidazol-4-yl-ethylamine

4-(2-Aminoethyl)-1H-imidazole

4-(2-Aminoethyl)imidazole

4-imidazoleethylamine

4-Imidazoleethylamine

51-45-6

53290_FLUKA

5-imidazoleethylamine

5-Imidazoleethylamine

64422-25-9

924364-91-0

AC-13185

AC1L19ZT

AC1Q54BV

AC1Q54BW

AKOS000274386

ALBB-005968

BCBcMAP01_000250

beta-aminoethylglyoxaline

beta-Aminoethylglyoxaline

beta-aminoethylimidazole

beta-Aminoethylimidazole

beta-aminothethylglyoxaline

beta-Aminothethylglyoxaline

beta-Imidazolyl-4-ethylamine

b-Imidazolyl-4-ethylamine

Bio1_000487

Bio1_000976

Bio1_001465

Bio2_000389

Bio2_000869

bmse000744

BSPBio_001117

BSPBio_002124

C00388

CCRIS 6535

Ceplene

CHEBI:18295

CHEMBL90

CID774

D08040

Dihydrochloride, histamine

DivK1c_000308

EINECS 200-100-6

Eramin

Ergamine

Ergotidine

F411C768-A159-4FC0-A195-291A08BB03AA

Free histamine

H7125_SIGMA

histamine

Histamine (DCF)

Histamine [USAN]

Histamine Base

Histamine dihydrochloride

Histamine hydrochloride

Histamine, Free Base

Histaminum

Histaminum (TN)

HMS1362G19

HMS1792G19

HMS1990G19

HSDB 3338

HSM

Hydrochloride, histamine

IDI1_000308

IDI1_002144

Imidazole-4-ethylamine

Istamina

Istamina [Italian]

KBio1_000308

KBio2_000457

KBio2_001325

KBio2_003025

KBio2_003893

KBio2_005593

KBio2_006461

KBio3_000853

KBio3_000854

KBio3_001344

KBioGR_000457

KBioGR_001580

KBioSS_000457

KBioSS_001325

L000292

L-Histamin base

L-histamine

L-Histamine

Lopac0_000595

Lopac-H-7250

LS-75835

MLS000069447

MolPort-001-785-597

MolPort-002-042-264

NCGC00015513-01

NCGC00015513-08

NCGC00093371-02

NCGC00093371-03

NCGC00093371-04

NCGC00093371-05

nchembio.87-comp54

nchembio714-comp1

NINDS_000308

NSC 33792

NSC33792

Peremin

SDCCGMLS-0066601.P001

SMP1_000151

SMR000059091

SPBio_000729

Spectrum_000845

Spectrum2_000665

Spectrum3_000452

Spectrum4_000960

Spectrum5_000796

ST073926

STK346752

STOCK5S-55669

Theramine

UNII-820484N8I3

WLN: T5M CNJ D2Z

ZERO/004089

2

Cyproheptadine

Approved

Phase 3

129-03-3

2913

Synonyms:

129-03-3

1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine

1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine

1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine

1-Methyl-4-(5H-dibenzo(a,D)cycloheptenylidene)piperidine

4-(5-dibenzo(a,D)Cyclohepten-5-ylidine)-1-methylpiperidine

4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine

4-(5-Dibenzo(a,D)cyclohepten-5-ylidine)-1-methylpiperidine

4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene

4-(5H-dibenzo(a,D)Cyclohepten-5-ylidene)-1-methylpiperidine

4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine

4-(5H-Dibenzo(a,D)cyclohepten-5-ylidene)-1-methylpiperidine

4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine

4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine

41354-29-4

4-dibenzo[a,D]Cyclohepten-5-ylidene-1-methyl-piperidine

4-Dibenzo[a,D]cyclohepten-5-ylidene-1-methyl-piperidine

5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene

5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene

5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,D)cyclopheptene

5-20-08-00500 (Beilstein Handbook Reference)

AC1L1ER8

AKOS004119847

Antergan

Axoprol

BIDD:GT0324

Biomol-NT_000131

BPBio1_000096

BPBio1_000155

BRD-K28143534-001-01-4

BRD-K28143534-003-03-6

BRN 1685976

BSPBio_000086

C06935

CAS-969-33-5

CCRIS 5232

CHEBI:4046

CHEMBL516

CID2913

Ciproheptadina

Ciproheptadina [INN-Spanish]

Ciprovit

Ciprovit (TN)

Cypoheptadine

Cyproheptadiene

Cyproheptadin

Cyproheptadine

CYPROHEPTADINE

Cyproheptadine (INN)

Cyproheptadine [INN:BAN]

Cyproheptadine Hcl

Cyproheptadinum

Cyproheptadinum [INN-Latin]

D07765

DB00434

Dibenzosuberonone/Cyproheptadine

Dihexazin

Dronactin

EINECS 204-928-9

Eiproheptadine

Glutodina

HMS2090P20

HSDB 3048

L001016

Lopac0_000246

Lopac-C-6022

LS-114933

MK 141

MolPort-002-507-777

NCGC00015252-01

NCGC00015252-02

NCGC00015252-03

NCGC00015252-09

NCGC00024293-02

NCGC00024293-04

NCGC00024293-05

nchembio.559-comp10

Oprea1_498140

PDSP1_001229

PDSP2_001213

Periactin

Periactine

Periactinol

Peritol

Prestwick0_000103

Prestwick1_000103

Prestwick2_000103

Prestwick3_000103

SPBio_002025

STK802098

Tocris-0996

UNII-2YHB6175DO

Viternum

3

Dermatologic Agents

Phase 3,Phase 1

4

Serotonin Agents

Phase 3

5

Anti-Allergic Agents

Phase 3

6

Serotonin Antagonists

Phase 3

7

Histamine H1 Antagonists

Phase 3

8

Histamine Phosphate

Phase 3

51-74-1

65513

Synonyms:

1H-Imidazole-4-ethanamine, phosphate (1:2)

2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)

4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)

4-(2-Aminoethyl)imidazole di-acid phosphate

4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate

51-74-1

53623-99-7

74-56-6

AC1L23E4

CID65513

D04445

DB00667

EINECS 200-118-4

H0147

Histamine acid phosphate

Histamine biphosphate

Histamine dihydrogen phosphate

Histamine diphosphate

Histamine phosphate (1:2)

Histamine phosphate (TN)

Histamine phosphate (USP)

Histamine phosphate [USP]

Histamine positive

LS-78569

UNII-QWB37T4WZZ

9

Antipruritics

Phase 3

10

Neurotransmitter Agents

Phase 3

11

Histamine Antagonists

Phase 3

12

Gastrointestinal Agents

Phase 3,Not Applicable

13

Serotonin

Investigational, Nutraceutical

Phase 3

50-67-9

5202

Synonyms:

3-(2-Aminoethyl)-1H-indol-5-ol

3-(2-Aminoethyl)indol-5-ol

3-(b-Aminoethyl)-5-hydroxyindole

5 Hydroxytryptamine

5-HT

5-HTA

5-Hydroxy-3-(b-aminoethyl)indole

5-Hydroxyltryptamine

5-Hydroxytriptamine

5-Hydroxytryptamine

5-Hydroxy-tryptamine

Antemovis

DS Substance

Enteramin

Enteramine

Hippophaine

Hydroxytryptamine

Serotonine

sérotonine

thrombocytin

Thrombocytin

thrombotonin

Thrombotonin

14

Lenalidomide

Approved

Phase 2

191732-72-6

216326

Synonyms:

191732-72-6

1-oxo-2-(2,6-Dioxopiperidin-3-yl)-4-aminoisoindoline

3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione

3-(4-amino-1-Oxoisoindolin-2-yl)piperidine-2,6-dione

3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione

346670-73-3

443912-14-9

AC1L50II

AC-914

AKOS005146276

ALBB-015321

Bio-0168

C467567

CC 5013

CC5013

CC-5013

CC-5013, Revlimid, Lenalidomide

CDC 501

CDC-501

CDC-5013

Celgene brand of lenalidomide

Celgene brand OF lenalidomide

CHEMBL848

CID216326

D04687

DB00480

EC-000.2340

ENMD-0997

I06-0831

IMid-1

IMID-1

IMiD3

IMiD3 cpd

IMiD3 CPD

IMID-5013

lenalidomide

Lenalidomide

Lenalidomide (USAN/INN)

Lenalidomide [USAN]

LS-184040

MolPort-003-848-370

NCGC00167491-01

NSC747972

Revamid

Revimid

Revlimid

Revlimid (Celgene)

Revlimid (TN)

S1029_Selleck

STK639603

Thalidomide analog CC-5013

UNII-F0P408N6V4

15

Anti-Bacterial Agents

Phase 2

16

Immunosuppressive Agents

Phase 2

17

Angiogenesis Modulating Agents

Phase 2

18

Angiogenesis Inhibitors

Phase 2

19

Immunologic Factors

Phase 2

20

Anti-Infective Agents

Phase 2

21

Verteporfin

Approved, Investigational

Phase 1

129497-78-5

22

Trioxsalen

Approved

Phase 1

3902-71-4

5585

Synonyms:

2',4,8-Trimethylpsoralen

2,5,9-Trimethyl-7H-furo(3,2-g)benzopyran-7-one

4,5',8-Trimethylpsoralen

4,8,5'-Trimethylpsoralen

6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylate, delta-lactone

6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylate, δ-lactone

6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone

6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone

6-Hydroxy-beta,2,7-trimethyl-5-benzofuranacrylate, delta-lactone

6-Hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone

6-Hydroxy-β,2,7-trimethyl-5-benzofuranacrylate, δ-lactone

6-Hydroxy-β,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone

ICN brand OF trioxsalen

trimethylpsoralen

Trimethylpsoralen

Trioxisaleno

Trioxisalenum

Trioxsalen

trioxysalen

Trioxysalen

Trioxysalene

Trioxysalenum

trisoralen

Trisoralen

23

Photosensitizing Agents

Phase 1

24

Dihematoporphyrin Ether

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer	Terminated	NCT01132547	Phase 3	cyproheptadine hydrochloride
2	Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma	Recruiting	NCT01089101	Phase 1, Phase 2	Selumetinib
3	Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma	Active, not recruiting	NCT01553149	Phase 2	Lenalidomide
4	Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors	Unknown status	NCT00002647	Phase 1	verteporfin
5	Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma	Completed	NCT01273090	Phase 1	imetelstat sodium
6	Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors	Withdrawn	NCT02194452	Not Applicable

Search NIH Clinical Center for Childhood Pilocytic Astrocytoma

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Genetic Tests for Childhood Pilocytic Astrocytoma

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Anatomical Context for Childhood Pilocytic Astrocytoma

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Publications for Childhood Pilocytic Astrocytoma

Articles related to Childhood Pilocytic Astrocytoma:

#	Title	Authors	Year
1	Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior. ( 30428478 )	Tu A...Krieger M	2018
2	The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma. ( 30530705 )	Buhl JL...Milde T	2018
3	Proteomics studies of childhood pilocytic astrocytoma. ( 21466243 )		2011
4	Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma. ( 18670637 )	Potter N...Warr TJ	2008

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Genes for Childhood Pilocytic Astrocytoma

Genes related to Childhood Pilocytic Astrocytoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NTM	Neurotrimin	Protein Coding	15.72	DISEASES inferred ¹⁵
2	DOCK2	Dedicator Of Cytokinesis 2	Protein Coding	15.45	DISEASES inferred ¹⁵
3	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	15.43	DISEASES inferred ¹⁵
4	NF1	Neurofibromin 1	Protein Coding	15.33	DISEASES inferred ¹⁵
5	CNTNAP1	Contactin Associated Protein 1	Protein Coding	15.26	DISEASES inferred ¹⁵
6	PBX3	PBX Homeobox 3	Protein Coding	15.2	DISEASES inferred ¹⁵

Sources

Variations for Childhood Pilocytic Astrocytoma

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Expression for Childhood Pilocytic Astrocytoma

Search GEO for disease gene expression data for Childhood Pilocytic Astrocytoma.

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Pathways for Childhood Pilocytic Astrocytoma

Pathways related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	11.33	CNTNAP1 NF1 SH3GL2
2	L1CAM interactions ⁶⁶ Show member pathways CHL1 interactions ⁶⁶ Neurofascin interactions ⁶⁶ NrCAM interactions ⁶⁶	11.05	CNTNAP1 SH3GL2

Sources

GO Terms for Childhood Pilocytic Astrocytoma

Cellular components related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	presynapse	GO:0098793	8.62	NF1 SH3GL2

Biological processes related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoskeleton organization	GO:0007010	9.26	CNTNAP1 DOCK2
2	actin cytoskeleton organization	GO:0030036	9.16	DOCK2 NF1
3	neuron projection development	GO:0031175	8.96	CNTNAP1 SH3GL2
4	myelination in peripheral nervous system	GO:0022011	8.62	CNTNAP1 NF1

Sources

Sources for Childhood Pilocytic Astrocytoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

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⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

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⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia