Childhood Pilocytic Astrocytoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Childhood Pilocytic Astrocytoma

MalaCards integrated aliases for Childhood Pilocytic Astrocytoma:

Name: Childhood Pilocytic Astrocytoma ¹¹ ¹⁴ ⁷¹

Pediatric Pilocytic Astrocytoma ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:6812

NCIt ⁴⁹ C4048

UMLS ⁷¹ C1332995

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Summaries for Childhood Pilocytic Astrocytoma

Disease Ontology: ¹¹ A pilocytic astrocytoma that occurs during childhood.

MalaCards based summary: Childhood Pilocytic Astrocytoma, also known as pediatric pilocytic astrocytoma, is related to pilocytic astrocytoma and spinal cord astrocytoma, and has symptoms including headache An important gene associated with Childhood Pilocytic Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways/superpathways are Oncogenic MAPK signaling and G-protein signaling TC21 regulation pathway. The drugs Lenalidomide and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain.

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Related Diseases for Childhood Pilocytic Astrocytoma

Diseases related to Childhood Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)

#	Related Disease	Score	Top Affiliating Genes
1	pilocytic astrocytoma	28.9	RNF130 NF1 KIAA1549 FGFR1 FAM131B BRAF
2	spinal cord astrocytoma	10.2	NF1 KIAA1549
3	epidural spinal canal neoplasm	10.2	NF1 KIAA1549
4	spinal cord glioma	10.2	NF1 KIAA1549
5	neurofibromatosis, type i	10.2
6	neurofibromatosis-noonan syndrome	10.2
7	neurofibromatosis	10.2
8	spinal cancer	10.2	NF1 KIAA1549
9	subependymal glioma	10.2	NF1 KIAA1549
10	obstructive hydrocephalus	10.1	NF1 KIAA1549
11	acral lentiginous melanoma	10.1	NF1 BRAF
12	optic nerve neoplasm	10.1	NF1 KIAA1549 FAM131B
13	optic nerve glioma	10.1	NF1 KIAA1549 FAM131B
14	non-langerhans-cell histiocytosis	10.1	NF1 BRAF
15	diffuse astrocytoma	10.1	NF1 KIAA1549 FAM131B
16	benign ependymoma	10.1	NF1 KIAA1549
17	pulmonic stenosis	10.1	NF1 BRAF
18	nodular malignant melanoma	10.1	NF1 BRAF
19	childhood astrocytic tumor	10.1	KIAA1549 FAM131B BRAF
20	simple partial epilepsy	10.1	KIAA1549 FGFR1
21	glioma susceptibility 1	10.1
22	brain cancer	10.1
23	adult oligodendroglioma	10.1	KIAA1549 FGFR1
24	alpha-thalassemia/mental retardation syndrome, x-linked	10.1
25	childhood oligodendroglioma	10.0	KIAA1549 FGFR1
26	spinal cord oligodendroglioma	10.0	NF1 FGFR1
27	mucosal melanoma	10.0	NF1 BRAF
28	subependymal giant cell astrocytoma	10.0	NF1 KIAA1549
29	juvenile pilocytic astrocytoma	10.0	RSBN1L NF1 KIAA1549
30	neurofibrosarcoma	10.0	NF1 FGFR1
31	pleomorphic xanthoastrocytoma	10.0	NF1 KIAA1549 FAM131B BRAF
32	spinal cord disease	9.9	NF1 KIAA1549 FGFR1
33	fibrillary astrocytoma	9.9	SRGAP2 NF1 KIAA1549 FAM131B
34	giant cell glioblastoma	9.9	NF1 FGFR1 BRAF
35	oligodendroglioma	9.8	NF1 FGFR1 BRAF
36	low grade glioma	9.8	NF1 KIAA1549 FGFR1 FAM131B
37	central nervous system benign neoplasm	9.8	NF1 KIAA1549 FGFR1 FAM131B
38	brain stem glioma	9.8	FGFR1 BRAF
39	gliosarcoma	9.8	NF1 FGFR1 BRAF
40	rasopathy	9.7	NF1 KIAA1549 FGFR1 BRAF
41	cerebellum cancer	9.7	RNF130 NF1 KIAA1549 FAM131B
42	papillary craniopharyngioma	9.7	RNF130 KIAA1549 FAM131B BRAF
43	pilocytic astrocytoma of cerebellum	9.5	RNF130 NF1 KIAA1549 FAM131B BRAF
44	cerebellar astrocytoma	9.5	RNF130 NF1 KIAA1549 FAM131B BRAF
45	gastrointestinal stromal tumor	9.5	NF1 FGFR1 BRAF
46	dysembryoplastic neuroepithelial tumor	9.4	RNF130 NF1 KIAA1549 FGFR1 FAM131B
47	pilomyxoid astrocytoma	9.0	SRGAP2 RNF130 NF1 KIAA1549 FGFR1 FAM131B

Graphical network of the top 20 diseases related to Childhood Pilocytic Astrocytoma:

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Symptoms & Phenotypes for Childhood Pilocytic Astrocytoma

UMLS symptoms related to Childhood Pilocytic Astrocytoma:

headache

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Drugs & Therapeutics for Childhood Pilocytic Astrocytoma

Drugs for Childhood Pilocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Lenalidomide

Approved

Phase 2

191732-72-6

216326

2

Angiogenesis Inhibitors

Phase 2

3

Immunologic Factors

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase 1 and Phase II and Re-Treatment Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma	Active, not recruiting	NCT01089101	Phase 1, Phase 2	Selumetinib
2	A Phase II Randomized Trial of Lenalidomide (NSC # 703813) in Pediatric Patients With Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas	Active, not recruiting	NCT01553149	Phase 2	Lenalidomide
3	Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors	Withdrawn	NCT02194452

Search NIH Clinical Center for Childhood Pilocytic Astrocytoma

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Genetic Tests for Childhood Pilocytic Astrocytoma

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Anatomical Context for Childhood Pilocytic Astrocytoma

Organs/tissues related to Childhood Pilocytic Astrocytoma:

MalaCards : Brain

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Publications for Childhood Pilocytic Astrocytoma

Articles related to Childhood Pilocytic Astrocytoma:

(show all 30)

#	Title	Authors	PMID	Year
1	Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling. ⁶²	Anastasaki C...Gutmann DH	35986378	2022
2	Genetic and histopathological associations with outcome in pediatric pilocytic astrocytoma. ⁶²	Cler SJ...Strahle JM	35148515	2022
3	Primary pilocytic astrocytoma of the cerebellopontine angle in pediatric patient with neurofibromatosis type 1: a case report. ⁶²	Zakaria Z...Rahman NAA	36061231	2022
4	Is it a new culprit? "TERT promoter mutation" in an aggressive pediatric pilocytic astrocytoma. ⁶²	Francis JV...Ozek MM	32813054	2021
5	hTERT Transduction Extends the Lifespan of Primary Pediatric Low-Grade Glioma Cells While Preserving the Biological Response to NGF. ⁶²	Franzese O...Ruggiero A	34257579	2021
6	mRNA and miRNA Expression Analyses of the MYC/E2F/miR-17-92 Network in the Most Common Pediatric Brain Tumors. ⁶²	Gruszka R...Zakrzewska M	33430425	2021
7	Decreased NSG3 enhances PD-L1 expression by Erk1/2 pathway to promote pancreatic cancer progress. ⁶²	Xia X...Wang R	33791163	2021
8	Immune Checkpoint-Associated Locations of Diffuse Gliomas Comparing Pediatric With Adult Patients Based on Voxel-Wise Analysis. ⁶²	Zhang L...Zhang J	33815356	2021
9	Multiple Lesions Accompanied by Postoperative Spontaneous Intracystic Hemorrhage in a Pediatric Patient with Pilocytic Astrocytoma. ⁶²	Parenrengi MA...Aji YK	32656142	2020
10	The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma. ⁶²	Buhl JL...Milde T	30530705	2019
11	Novel Surgical and Radiologic Risk Factors for Progression or Recurrence of Pediatric Pilocytic Astrocytoma. ⁶²	Villanueva KG...Krieger MD	31593969	2019
12	Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior. ⁶²	Tu A...Krieger M	30428478	2018
13	Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. ⁶²	Selt F...Milde T	28002790	2017
14	Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy. ⁶²	Xi G...Tomita T	28137267	2017
15	Midbrain Gliofibroma Presenting in Adulthood following "Cure" of a Childhood Intraventricular Pilocytic Astrocytoma. ⁶²	Ahmad MU...Jenkinson MD	28245445	2017
16	Low rates of recurrence and slow progression of pediatric pilocytic astrocytoma after gross-total resection: justification for reducing surveillance imaging. ⁶²	Dodgshun AJ...Sullivan MJ	26722760	2016
17	Retraction: Screening genes crucial for pediatric pilocytic astrocytoma using weighted gene coexpression network analysis combined with methylation data analysis. ⁶²		26685762	2016
18	Proteomic study of pilocytic astrocytoma pediatric brain tumor intracystic fluid. ⁶²	Inserra I...Desiderio C	25254300	2014
19	Screening genes crucial for pediatric pilocytic astrocytoma using weighted gene coexpression network analysis combined with methylation data analysis. ⁶²	Zhao H...Liu S	25257306	2014
20	Diagnostic challenges of primary thalamic gliomas-identification of a minimally enhancing neuroradiological subtype with aggressive neuropathology and poor clinical outcome. ⁶²	Kurian KM...Bradley M	23708758	2014
21	Radiotherapy in pediatric pilocytic astrocytomas. A subgroup analysis within the prospective multicenter study HIT-LGG 1996 by the German Society of Pediatric Oncology and Hematology (GPOH). ⁶²	Muller K...Kortmann RD	23831852	2013
22	MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. ⁶²	Ho CY...Rodriguez FJ	23161775	2013
23	[Pediatric pilocytic astrocytoma with monomorphous pilomyxoid features and plexiform pattern: report of a case]. ⁶²	Zhou J...Yang GY	22169652	2011
24	Proteomics studies of childhood pilocytic astrocytoma. ⁶²	Anagnostopoulos AK...Tsangaris GT	21466243	2011
25	Pediatric primary pilocytic astrocytoma of the cerebellopontine angle: a case report. ⁶²	Mirone G...George B	18690462	2009
26	Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma. ⁶²	Potter N...Warr TJ	18670637	2008
27	Expression of SOX9 and SOX10 in central neuroepithelial tumor. ⁶²	Kordes U...Hagel C	16791471	2006
28	Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma. ⁶²	Cirak B...Avellino AM	15372294	2005
29	Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood. ⁶²	Gesundheit B...Becker L	14595708	2003
30	Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide. ⁶²	McCowage G...Friedman HS	8614389	1996

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Genes for Childhood Pilocytic Astrocytoma

Genes related to Childhood Pilocytic Astrocytoma (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KIAA1549	KIAA1549	Protein Coding	7.41	DISEASES inferred ¹⁴
2	IGBP1-AS1	IGBP1 Antisense RNA 1	RNA Gene	6.34	DISEASES inferred ¹⁴
3	CALY	Calcyon Neuron Specific Vesicular Protein	Protein Coding	6.11	DISEASES inferred ¹⁴
4	FAM131B	Family With Sequence Similarity 131 Member B	Protein Coding	5.65	DISEASES inferred ¹⁴
5	NF1	Neurofibromin 1	Protein Coding	5.5	DISEASES inferred ¹⁴
6	TUBG2	Tubulin Gamma 2	Protein Coding	5.25	DISEASES inferred ¹⁴
7	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	5.11	DISEASES inferred ¹⁴
8	ARHGEF7-AS2	ARHGEF7 Antisense RNA 2	RNA Gene	5.02	DISEASES inferred ¹⁴
9	MIR3684	MicroRNA 3684	RNA Gene	4.94	DISEASES inferred ¹⁴
10	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	4.89	DISEASES inferred ¹⁴
11	USP46-DT	USP46 Divergent Transcript	RNA Gene	4.88	DISEASES inferred ¹⁴
12	MIR4280	MicroRNA 4280	RNA Gene	4.82	DISEASES inferred ¹⁴
13	RSBN1L	Round Spermatid Basic Protein 1 Like	Protein Coding	4.82	DISEASES inferred ¹⁴
14	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	4.82	DISEASES inferred ¹⁴
15	RNF130	Ring Finger Protein 130	Protein Coding	4.82	DISEASES inferred ¹⁴
16	SRGAP2	SLIT-ROBO Rho GTPase Activating Protein 2	Protein Coding	4.8	DISEASES inferred ¹⁴

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Variations for Childhood Pilocytic Astrocytoma

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Expression for Childhood Pilocytic Astrocytoma

Search GEO for disease gene expression data for Childhood Pilocytic Astrocytoma.

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Pathways for Childhood Pilocytic Astrocytoma

Pathways related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Oncogenic MAPK signaling ⁶⁶ Show member pathways Signaling by BRAF and RAF1 fusions ⁶⁶	11.1	NF1 KIAA1549 FAM131B BRAF
2	G-protein signaling TC21 regulation pathway ²² Show member pathways G-protein signaling M-RAS regulation pathway ²² Negative feedback regulation of MAPK pathway ⁶⁶ Signaling by MAP2K mutants ⁶⁶	10.72	NF1 BRAF

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GO Terms for Childhood Pilocytic Astrocytoma

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Sources for Childhood Pilocytic Astrocytoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CHL062 MIFTS: 23	Childhood Pilocytic Astrocytoma Categories: Cancer diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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