MCID: CHL062
MIFTS: 28

Childhood Pilocytic Astrocytoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Childhood Pilocytic Astrocytoma

MalaCards integrated aliases for Childhood Pilocytic Astrocytoma:

Name: Childhood Pilocytic Astrocytoma 12 15 74
Pediatric Pilocytic Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6812
NCIt 51 C4048
UMLS 74 C1332995

Summaries for Childhood Pilocytic Astrocytoma

MalaCards based summary : Childhood Pilocytic Astrocytoma, also known as pediatric pilocytic astrocytoma, is related to pilocytic astrocytoma and astrocytoma, and has symptoms including headache An important gene associated with Childhood Pilocytic Astrocytoma is NTM (Neurotrimin), and among its related pathways/superpathways are Neuroscience and L1CAM interactions. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain and testes, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Childhood Pilocytic Astrocytoma

Diseases related to Childhood Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pilocytic astrocytoma 10.4
2 astrocytoma 10.2
3 heparin-induced thrombocytopenia 10.1
4 juvenile pilocytic astrocytoma 9.7 NF1 NTM

Symptoms & Phenotypes for Childhood Pilocytic Astrocytoma

UMLS symptoms related to Childhood Pilocytic Astrocytoma:


headache

MGI Mouse Phenotypes related to Childhood Pilocytic Astrocytoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 CNTNAP1 DOCK2 NF1 PBX3 SH3GL2
2 nervous system MP:0003631 9.35 CNTNAP1 DOCK2 NF1 PBX3 SH3GL2
3 skeleton MP:0005390 8.92 CNTNAP1 NF1 PBX3 SH3GL2

Drugs & Therapeutics for Childhood Pilocytic Astrocytoma

Drugs for Childhood Pilocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4 Histamine Antagonists Phase 3
5 Neurotransmitter Agents Phase 3
6 Gastrointestinal Agents Phase 3,Not Applicable
7 Serotonin Agents Phase 3
8 Serotonin Antagonists Phase 3
9 Anti-Allergic Agents Phase 3
10 Antipruritics Phase 3
11 Histamine H1 Antagonists Phase 3
12
Histamine Phosphate Phase 3 51-74-1 65513
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Lenalidomide Approved Phase 2 191732-72-6 216326
15 Angiogenesis Modulating Agents Phase 2
16 Immunologic Factors Phase 2
17 Angiogenesis Inhibitors Phase 2
18
Verteporfin Approved, Investigational Phase 1 129497-78-5
19
Trioxsalen Approved Phase 1 3902-71-4 5585
20
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
22
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
23
Imetelstat Investigational Phase 1 868169-64-6
24 Dihematoporphyrin Ether Phase 1
25 Photosensitizing Agents Phase 1
26 Nicotinic Acids Phase 1
27 Vitamin B3 Phase 1
28 Vitamins Phase 1
29 Trace Elements Phase 1
30 Folate Phase 1
31 Vitamin B Complex Phase 1
32
Motesanib diphosphate Phase 1 850649-62-6 11450633
33 Protein Kinase Inhibitors Phase 1
34 Micronutrients Phase 1
35 Nutrients Phase 1
36 Vitamin B9 Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Recruiting NCT01089101 Phase 1, Phase 2 Selumetinib
3 Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma Active, not recruiting NCT01553149 Phase 2 Lenalidomide
4 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
5 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Childhood Pilocytic Astrocytoma

Genetic Tests for Childhood Pilocytic Astrocytoma

Anatomical Context for Childhood Pilocytic Astrocytoma

MalaCards organs/tissues related to Childhood Pilocytic Astrocytoma:

42
Brain, Testes

Publications for Childhood Pilocytic Astrocytoma

Articles related to Childhood Pilocytic Astrocytoma:

# Title Authors Year
1
Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior. ( 30428478 )
2018
2
The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma. ( 30530705 )
2018
3
Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. ( 28002790 )
2017
4
Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy. ( 28137267 )
2017
5
Retraction: Screening genes crucial for pediatric pilocytic astrocytoma using weighted gene coexpression network analysis combined with methylation data analysis. ( 26685762 )
2016
6
Low rates of recurrence and slow progression of pediatric pilocytic astrocytoma after gross-total resection: justification for reducing surveillance imaging. ( 26722760 )
2016
7
Screening genes crucial for pediatric pilocytic astrocytoma using weighted gene coexpression network analysis combined with methylation data analysis. ( 25257306 )
2014
8
MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. ( 23161775 )
2013
9
Proteomics studies of childhood pilocytic astrocytoma. ( 21466243 )
2011
10
Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma. ( 18670637 )
2008

Variations for Childhood Pilocytic Astrocytoma

Expression for Childhood Pilocytic Astrocytoma

Search GEO for disease gene expression data for Childhood Pilocytic Astrocytoma.

Pathways for Childhood Pilocytic Astrocytoma

Pathways related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 CNTNAP1 NF1 SH3GL2
2
Show member pathways
11.05 CNTNAP1 SH3GL2

GO Terms for Childhood Pilocytic Astrocytoma

Cellular components related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 presynapse GO:0098793 8.62 NF1 SH3GL2

Biological processes related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton organization GO:0007010 9.26 CNTNAP1 DOCK2
2 actin cytoskeleton organization GO:0030036 9.16 DOCK2 NF1
3 neuron projection development GO:0031175 8.96 CNTNAP1 SH3GL2
4 myelination in peripheral nervous system GO:0022011 8.62 CNTNAP1 NF1

Sources for Childhood Pilocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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