MCID: CHL062
MIFTS: 26

Childhood Pilocytic Astrocytoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Childhood Pilocytic Astrocytoma

MalaCards integrated aliases for Childhood Pilocytic Astrocytoma:

Name: Childhood Pilocytic Astrocytoma 12 15 70
Pediatric Pilocytic Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6812
NCIt 50 C4048
UMLS 70 C1332995

Summaries for Childhood Pilocytic Astrocytoma

Disease Ontology : 12 A pilocytic astrocytoma that occurs during childhood.

MalaCards based summary : Childhood Pilocytic Astrocytoma, also known as pediatric pilocytic astrocytoma, is related to pilocytic astrocytoma and malignant astrocytoma, and has symptoms including headache An important gene associated with Childhood Pilocytic Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways/superpathways are Developmental Biology and Oncogenic MAPK signaling. Affiliated tissues include brain, bone and spinal cord.

Related Diseases for Childhood Pilocytic Astrocytoma

Diseases related to Childhood Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 pilocytic astrocytoma 29.5 SRGAP3 NF1 KIAA1549 IDH1 BRAF
2 malignant astrocytoma 29.3 NF1 KIAA1549 IDH1 H3-3B H3-3A BRAF
3 pediatric meningioma 10.3 LUC7L2 KIAA1549
4 malignant giant cell tumor 10.3 H3-3B H3-3A
5 bone giant cell sarcoma 10.3 H3-3B H3-3A
6 telangiectatic osteogenic sarcoma 10.3 H3-3B H3-3A
7 clear cell chondrosarcoma 10.2 H3-3B H3-3A
8 subependymal glioma 10.2 NF1 KIAA1549
9 colon leiomyoma 10.2 H3-3B H3-3A
10 avoidant personality disorder 10.2 SRGAP3 SRGAP2
11 chromosome 3pter-p25 deletion syndrome 10.2 SRGAP3 SRGAP2
12 urachal adenocarcinoma 10.2 NF1 BRAF
13 pulmonic stenosis 10.2 NF1 BRAF
14 optic nerve neoplasm 10.2 NF1 KIAA1549 FAM131B
15 bone benign neoplasm 10.1 H3-3B H3-3A
16 neurofibromatosis, type i 10.1 NF1 KIAA1549 FAM131B
17 spinal cord oligodendroglioma 10.1 NF1 IDH1
18 alpha thalassemia-x-linked intellectual disability syndrome 10.1 H3-3B H3-3A
19 glioma susceptibility 1 10.1
20 neurofibromatosis 10.0
21 mixed glioma 10.0 NF1 IDH1
22 ganglioglioma 10.0 NF1 H3-3A BRAF
23 papillary craniopharyngioma 10.0 KIAA1549 FAM131B BRAF
24 supratentorial primitive neuroectodermal tumor 10.0 LUC7L2 IDH1
25 gliofibroma 10.0 NF1 KIAA1549 IDH1
26 benign ependymoma 10.0 NF1 KIAA1549 IDH1
27 high grade ependymoma 10.0 KIAA1549 IDH1 H3-3A
28 supratentorial cancer 10.0 KIAA1549 IDH1
29 adult brain stem glioma 10.0 IDH1 H3-3B H3-3A
30 multiple enchondromatosis, maffucci type 10.0 IDH1 H3-3B
31 childhood brain stem glioma 10.0 IDH1 H3-3B H3-3A
32 chondroblastic osteosarcoma 10.0 IDH1 H3-3B H3-3A
33 li-fraumeni syndrome 9.9 NF1 LUC7L2 IDH1
34 bone giant cell tumor 9.9 H3-3B H3-3A
35 astroblastoma 9.9 IDH1 BRAF
36 anaplastic astrocytoma 9.9 IDH1 H3-3B H3-3A
37 spinal cord astrocytoma 9.9 KIAA1549 IDH1 H3-3B H3-3A
38 adult oligodendroglioma 9.9 KIAA1549 IDH1 H3-3B H3-3A
39 childhood oligodendroglioma 9.9 KIAA1549 IDH1 H3-3B H3-3A
40 gliomatosis cerebri 9.8 LUC7L2 IDH1
41 diffuse midline glioma, h3 k27m-mutant 9.8 KIAA1549 IDH1 H3-3B H3-3A
42 brain stem cancer 9.8 NF1 IDH1 H3-3B H3-3A
43 dysembryoplastic neuroepithelial tumor 9.8 LUC7L2 KIAA1549 IDH1 FAM131B
44 cerebellum cancer 9.8 NF1 KIAA1549 IDH1 FAM131B
45 infratentorial cancer 9.8 NF1 IDH1 H3-3B H3-3A
46 alpha-thalassemia 9.8 LUC7L2 IDH1 H3-3B H3-3A
47 plasma cell neoplasm 9.8 NF1 IDH1 BRAF
48 glioma 9.7 NF1 IDH1 H3-3A BRAF
49 adult astrocytic tumour 9.7 LUC7L2 KIAA1549 IDH1 H3-3B H3-3A
50 spinal cord glioma 9.7 LUC7L2 KIAA1549 IDH1 H3-3B H3-3A

Graphical network of the top 20 diseases related to Childhood Pilocytic Astrocytoma:



Diseases related to Childhood Pilocytic Astrocytoma

Symptoms & Phenotypes for Childhood Pilocytic Astrocytoma

UMLS symptoms related to Childhood Pilocytic Astrocytoma:


headache

Drugs & Therapeutics for Childhood Pilocytic Astrocytoma

Search Clinical Trials , NIH Clinical Center for Childhood Pilocytic Astrocytoma

Genetic Tests for Childhood Pilocytic Astrocytoma

Anatomical Context for Childhood Pilocytic Astrocytoma

MalaCards organs/tissues related to Childhood Pilocytic Astrocytoma:

40
Brain, Bone, Spinal Cord, Cerebellum, Colon

Publications for Childhood Pilocytic Astrocytoma

Articles related to Childhood Pilocytic Astrocytoma:

(show all 25)
# Title Authors PMID Year
1
Is it a new culprit? "TERT promoter mutation" in an aggressive pediatric pilocytic astrocytoma. 61
32813054 2021
2
mRNA and miRNA Expression Analyses of the MYC/E2F/miR-17-92 Network in the Most Common Pediatric Brain Tumors. 61
33430425 2021
3
Decreased NSG3 enhances PD-L1 expression by Erk1/2 pathway to promote pancreatic cancer progress. 61
33791163 2021
4
Multiple Lesions Accompanied by Postoperative Spontaneous Intracystic Hemorrhage in a Pediatric Patient with Pilocytic Astrocytoma. 61
32656142 2020
5
The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma. 61
30530705 2019
6
Novel Surgical and Radiologic Risk Factors for Progression or Recurrence of Pediatric Pilocytic Astrocytoma. 61
31593969 2019
7
Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior. 61
30428478 2018
8
Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. 61
28002790 2017
9
Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy. 61
28137267 2017
10
Midbrain Gliofibroma Presenting in Adulthood following "Cure" of a Childhood Intraventricular Pilocytic Astrocytoma. 61
28245445 2017
11
Low rates of recurrence and slow progression of pediatric pilocytic astrocytoma after gross-total resection: justification for reducing surveillance imaging. 61
26722760 2016
12
Retraction: Screening genes crucial for pediatric pilocytic astrocytoma using weighted gene coexpression network analysis combined with methylation data analysis. 61
26685762 2016
13
Proteomic study of pilocytic astrocytoma pediatric brain tumor intracystic fluid. 61
25254300 2014
14
Screening genes crucial for pediatric pilocytic astrocytoma using weighted gene coexpression network analysis combined with methylation data analysis. 61
25257306 2014
15
Diagnostic challenges of primary thalamic gliomas-identification of a minimally enhancing neuroradiological subtype with aggressive neuropathology and poor clinical outcome. 61
23708758 2014
16
Radiotherapy in pediatric pilocytic astrocytomas. A subgroup analysis within the prospective multicenter study HIT-LGG 1996 by the German Society of Pediatric Oncology and Hematology (GPOH). 61
23831852 2013
17
MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. 61
23161775 2013
18
[Pediatric pilocytic astrocytoma with monomorphous pilomyxoid features and plexiform pattern: report of a case]. 61
22169652 2011
19
Proteomics studies of childhood pilocytic astrocytoma. 61
21466243 2011
20
Pediatric primary pilocytic astrocytoma of the cerebellopontine angle: a case report. 61
18690462 2009
21
Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma. 61
18670637 2008
22
Expression of SOX9 and SOX10 in central neuroepithelial tumor. 61
16791471 2006
23
Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma. 61
15372294 2005
24
Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood. 61
14595708 2003
25
Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide. 61
8614389 1996

Variations for Childhood Pilocytic Astrocytoma

Expression for Childhood Pilocytic Astrocytoma

Search GEO for disease gene expression data for Childhood Pilocytic Astrocytoma.

Pathways for Childhood Pilocytic Astrocytoma

Pathways related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 SRGAP3 SRGAP2 SH3GL2 NF1 H3-3B H3-3A
2
Show member pathways
11.06 NF1 KIAA1549 FAM131B BRAF
3
Show member pathways
10.89 NF1 BRAF

GO Terms for Childhood Pilocytic Astrocytoma

Cellular components related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Barr body GO:0001740 8.62 H3-3B H3-3A

Biological processes related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell migration GO:0030336 9.58 SRGAP3 SRGAP2 NF1
2 osteoblast differentiation GO:0001649 9.5 NF1 H3-3B H3-3A
3 nucleus organization GO:0006997 9.48 H3-3B H3-3A
4 telomere organization GO:0032200 9.46 H3-3B H3-3A
5 DNA replication-independent nucleosome assembly GO:0006336 9.43 H3-3B H3-3A
6 muscle cell differentiation GO:0042692 9.37 H3-3B H3-3A
7 pericentric heterochromatin assembly GO:0031508 9.26 H3-3B H3-3A
8 regulation of centromere complex assembly GO:0090230 9.16 H3-3B H3-3A
9 negative regulation of chromosome condensation GO:1902340 8.96 H3-3B H3-3A
10 telomeric heterochromatin assembly GO:0031509 8.62 H3-3B H3-3A

Molecular functions related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3-3B H3-3A

Sources for Childhood Pilocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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