MCID: CHL062
MIFTS: 23

Childhood Pilocytic Astrocytoma

Categories: Cancer diseases, Neuronal diseases
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Aliases & Classifications for Childhood Pilocytic Astrocytoma

MalaCards integrated aliases for Childhood Pilocytic Astrocytoma:

Name: Childhood Pilocytic Astrocytoma 11 14 71
Pediatric Pilocytic Astrocytoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:6812
NCIt 49 C4048
UMLS 71 C1332995

Summaries for Childhood Pilocytic Astrocytoma

Disease Ontology: 11 A pilocytic astrocytoma that occurs during childhood.

MalaCards based summary: Childhood Pilocytic Astrocytoma, also known as pediatric pilocytic astrocytoma, is related to pilocytic astrocytoma and spinal cord astrocytoma, and has symptoms including headache An important gene associated with Childhood Pilocytic Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways/superpathways are Oncogenic MAPK signaling and G-protein signaling TC21 regulation pathway. The drugs Lenalidomide and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Childhood Pilocytic Astrocytoma

Diseases related to Childhood Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 pilocytic astrocytoma 28.9 RNF130 NF1 KIAA1549 FGFR1 FAM131B BRAF
2 spinal cord astrocytoma 10.2 NF1 KIAA1549
3 epidural spinal canal neoplasm 10.2 NF1 KIAA1549
4 spinal cord glioma 10.2 NF1 KIAA1549
5 neurofibromatosis, type i 10.2
6 neurofibromatosis-noonan syndrome 10.2
7 neurofibromatosis 10.2
8 spinal cancer 10.2 NF1 KIAA1549
9 subependymal glioma 10.2 NF1 KIAA1549
10 obstructive hydrocephalus 10.1 NF1 KIAA1549
11 acral lentiginous melanoma 10.1 NF1 BRAF
12 optic nerve neoplasm 10.1 NF1 KIAA1549 FAM131B
13 optic nerve glioma 10.1 NF1 KIAA1549 FAM131B
14 non-langerhans-cell histiocytosis 10.1 NF1 BRAF
15 diffuse astrocytoma 10.1 NF1 KIAA1549 FAM131B
16 benign ependymoma 10.1 NF1 KIAA1549
17 pulmonic stenosis 10.1 NF1 BRAF
18 nodular malignant melanoma 10.1 NF1 BRAF
19 childhood astrocytic tumor 10.1 KIAA1549 FAM131B BRAF
20 simple partial epilepsy 10.1 KIAA1549 FGFR1
21 glioma susceptibility 1 10.1
22 brain cancer 10.1
23 adult oligodendroglioma 10.1 KIAA1549 FGFR1
24 alpha-thalassemia/mental retardation syndrome, x-linked 10.1
25 childhood oligodendroglioma 10.0 KIAA1549 FGFR1
26 spinal cord oligodendroglioma 10.0 NF1 FGFR1
27 mucosal melanoma 10.0 NF1 BRAF
28 subependymal giant cell astrocytoma 10.0 NF1 KIAA1549
29 juvenile pilocytic astrocytoma 10.0 RSBN1L NF1 KIAA1549
30 neurofibrosarcoma 10.0 NF1 FGFR1
31 pleomorphic xanthoastrocytoma 10.0 NF1 KIAA1549 FAM131B BRAF
32 spinal cord disease 9.9 NF1 KIAA1549 FGFR1
33 fibrillary astrocytoma 9.9 SRGAP2 NF1 KIAA1549 FAM131B
34 giant cell glioblastoma 9.9 NF1 FGFR1 BRAF
35 oligodendroglioma 9.8 NF1 FGFR1 BRAF
36 low grade glioma 9.8 NF1 KIAA1549 FGFR1 FAM131B
37 central nervous system benign neoplasm 9.8 NF1 KIAA1549 FGFR1 FAM131B
38 brain stem glioma 9.8 FGFR1 BRAF
39 gliosarcoma 9.8 NF1 FGFR1 BRAF
40 rasopathy 9.7 NF1 KIAA1549 FGFR1 BRAF
41 cerebellum cancer 9.7 RNF130 NF1 KIAA1549 FAM131B
42 papillary craniopharyngioma 9.7 RNF130 KIAA1549 FAM131B BRAF
43 pilocytic astrocytoma of cerebellum 9.5 RNF130 NF1 KIAA1549 FAM131B BRAF
44 cerebellar astrocytoma 9.5 RNF130 NF1 KIAA1549 FAM131B BRAF
45 gastrointestinal stromal tumor 9.5 NF1 FGFR1 BRAF
46 dysembryoplastic neuroepithelial tumor 9.4 RNF130 NF1 KIAA1549 FGFR1 FAM131B
47 pilomyxoid astrocytoma 9.0 SRGAP2 RNF130 NF1 KIAA1549 FGFR1 FAM131B

Graphical network of the top 20 diseases related to Childhood Pilocytic Astrocytoma:



Diseases related to Childhood Pilocytic Astrocytoma

Symptoms & Phenotypes for Childhood Pilocytic Astrocytoma

UMLS symptoms related to Childhood Pilocytic Astrocytoma:


headache

Drugs & Therapeutics for Childhood Pilocytic Astrocytoma

Drugs for Childhood Pilocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenalidomide Approved Phase 2 191732-72-6 216326
2 Angiogenesis Inhibitors Phase 2
3 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 1 and Phase II and Re-Treatment Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma Active, not recruiting NCT01089101 Phase 1, Phase 2 Selumetinib
2 A Phase II Randomized Trial of Lenalidomide (NSC # 703813) in Pediatric Patients With Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas Active, not recruiting NCT01553149 Phase 2 Lenalidomide
3 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Childhood Pilocytic Astrocytoma

Genetic Tests for Childhood Pilocytic Astrocytoma

Anatomical Context for Childhood Pilocytic Astrocytoma

Organs/tissues related to Childhood Pilocytic Astrocytoma:

MalaCards : Brain

Publications for Childhood Pilocytic Astrocytoma

Articles related to Childhood Pilocytic Astrocytoma:

(show all 30)
# Title Authors PMID Year
1
Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling. 62
35986378 2022
2
Genetic and histopathological associations with outcome in pediatric pilocytic astrocytoma. 62
35148515 2022
3
Primary pilocytic astrocytoma of the cerebellopontine angle in pediatric patient with neurofibromatosis type 1: a case report. 62
36061231 2022
4
Is it a new culprit? "TERT promoter mutation" in an aggressive pediatric pilocytic astrocytoma. 62
32813054 2021
5
hTERT Transduction Extends the Lifespan of Primary Pediatric Low-Grade Glioma Cells While Preserving the Biological Response to NGF. 62
34257579 2021
6
mRNA and miRNA Expression Analyses of the MYC/E2F/miR-17-92 Network in the Most Common Pediatric Brain Tumors. 62
33430425 2021
7
Decreased NSG3 enhances PD-L1 expression by Erk1/2 pathway to promote pancreatic cancer progress. 62
33791163 2021
8
Immune Checkpoint-Associated Locations of Diffuse Gliomas Comparing Pediatric With Adult Patients Based on Voxel-Wise Analysis. 62
33815356 2021
9
Multiple Lesions Accompanied by Postoperative Spontaneous Intracystic Hemorrhage in a Pediatric Patient with Pilocytic Astrocytoma. 62
32656142 2020
10
The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma. 62
30530705 2019
11
Novel Surgical and Radiologic Risk Factors for Progression or Recurrence of Pediatric Pilocytic Astrocytoma. 62
31593969 2019
12
Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior. 62
30428478 2018
13
Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. 62
28002790 2017
14
Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy. 62
28137267 2017
15
Midbrain Gliofibroma Presenting in Adulthood following "Cure" of a Childhood Intraventricular Pilocytic Astrocytoma. 62
28245445 2017
16
Low rates of recurrence and slow progression of pediatric pilocytic astrocytoma after gross-total resection: justification for reducing surveillance imaging. 62
26722760 2016
17
Retraction: Screening genes crucial for pediatric pilocytic astrocytoma using weighted gene coexpression network analysis combined with methylation data analysis. 62
26685762 2016
18
Proteomic study of pilocytic astrocytoma pediatric brain tumor intracystic fluid. 62
25254300 2014
19
Screening genes crucial for pediatric pilocytic astrocytoma using weighted gene coexpression network analysis combined with methylation data analysis. 62
25257306 2014
20
Diagnostic challenges of primary thalamic gliomas-identification of a minimally enhancing neuroradiological subtype with aggressive neuropathology and poor clinical outcome. 62
23708758 2014
21
Radiotherapy in pediatric pilocytic astrocytomas. A subgroup analysis within the prospective multicenter study HIT-LGG 1996 by the German Society of Pediatric Oncology and Hematology (GPOH). 62
23831852 2013
22
MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. 62
23161775 2013
23
[Pediatric pilocytic astrocytoma with monomorphous pilomyxoid features and plexiform pattern: report of a case]. 62
22169652 2011
24
Proteomics studies of childhood pilocytic astrocytoma. 62
21466243 2011
25
Pediatric primary pilocytic astrocytoma of the cerebellopontine angle: a case report. 62
18690462 2009
26
Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma. 62
18670637 2008
27
Expression of SOX9 and SOX10 in central neuroepithelial tumor. 62
16791471 2006
28
Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma. 62
15372294 2005
29
Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood. 62
14595708 2003
30
Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide. 62
8614389 1996

Variations for Childhood Pilocytic Astrocytoma

Expression for Childhood Pilocytic Astrocytoma

Search GEO for disease gene expression data for Childhood Pilocytic Astrocytoma.

Pathways for Childhood Pilocytic Astrocytoma

Pathways related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.1 NF1 KIAA1549 FAM131B BRAF
2
Show member pathways
10.72 NF1 BRAF

GO Terms for Childhood Pilocytic Astrocytoma

Sources for Childhood Pilocytic Astrocytoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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