MCID: CHL062
MIFTS: 24

Childhood Pilocytic Astrocytoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Childhood Pilocytic Astrocytoma

MalaCards integrated aliases for Childhood Pilocytic Astrocytoma:

Name: Childhood Pilocytic Astrocytoma 12 15 73
Pediatric Pilocytic Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6812
NCIt 50 C4048
UMLS 73 C1332995

Summaries for Childhood Pilocytic Astrocytoma

MalaCards based summary : Childhood Pilocytic Astrocytoma, also known as pediatric pilocytic astrocytoma, is related to astrocytoma and pilocytic astrocytoma, and has symptoms including headache An important gene associated with Childhood Pilocytic Astrocytoma is NTM (Neurotrimin), and among its related pathways/superpathways are Neuroscience and L1CAM interactions. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and nervous system

Related Diseases for Childhood Pilocytic Astrocytoma

Diseases related to Childhood Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 astrocytoma 10.1
2 pilocytic astrocytoma 10.1
3 juvenile pilocytic astrocytoma 9.8 NF1 NTM

Symptoms & Phenotypes for Childhood Pilocytic Astrocytoma

UMLS symptoms related to Childhood Pilocytic Astrocytoma:


headache

MGI Mouse Phenotypes related to Childhood Pilocytic Astrocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 CNTNAP1 DOCK2 NF1 PBX3 SH3GL2
2 nervous system MP:0003631 9.35 CNTNAP1 DOCK2 NF1 PBX3 SH3GL2
3 skeleton MP:0005390 8.92 CNTNAP1 NF1 PBX3 SH3GL2

Drugs & Therapeutics for Childhood Pilocytic Astrocytoma

Drugs for Childhood Pilocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4 Serotonin Agents Phase 3
5 Anti-Allergic Agents Phase 3
6 Serotonin Antagonists Phase 3
7 Histamine H1 Antagonists Phase 3
8
Histamine Phosphate Phase 3 51-74-1 65513
9 Antipruritics Phase 3
10 Neurotransmitter Agents Phase 3
11 Histamine Antagonists Phase 3
12 Gastrointestinal Agents Phase 3,Not Applicable
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Lenalidomide Approved Phase 2 191732-72-6 216326
15 Anti-Bacterial Agents Phase 2
16 Immunosuppressive Agents Phase 2
17 Angiogenesis Modulating Agents Phase 2
18 Angiogenesis Inhibitors Phase 2
19 Immunologic Factors Phase 2
20 Anti-Infective Agents Phase 2
21
Verteporfin Approved, Investigational Phase 1 129497-78-5
22
Trioxsalen Approved Phase 1 3902-71-4 5585
23 Photosensitizing Agents Phase 1
24 Dihematoporphyrin Ether Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Recruiting NCT01089101 Phase 1, Phase 2 Selumetinib
3 Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma Active, not recruiting NCT01553149 Phase 2 Lenalidomide
4 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
5 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Childhood Pilocytic Astrocytoma

Genetic Tests for Childhood Pilocytic Astrocytoma

Anatomical Context for Childhood Pilocytic Astrocytoma

Publications for Childhood Pilocytic Astrocytoma

Articles related to Childhood Pilocytic Astrocytoma:

# Title Authors Year
1
Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior. ( 30428478 )
2018
2
The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma. ( 30530705 )
2018
3
Proteomics studies of childhood pilocytic astrocytoma. ( 21466243 )
2011
4
Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma. ( 18670637 )
2008

Variations for Childhood Pilocytic Astrocytoma

Expression for Childhood Pilocytic Astrocytoma

Search GEO for disease gene expression data for Childhood Pilocytic Astrocytoma.

Pathways for Childhood Pilocytic Astrocytoma

Pathways related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 CNTNAP1 NF1 SH3GL2
2
Show member pathways
11.05 CNTNAP1 SH3GL2

GO Terms for Childhood Pilocytic Astrocytoma

Cellular components related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 presynapse GO:0098793 8.62 NF1 SH3GL2

Biological processes related to Childhood Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton organization GO:0007010 9.26 CNTNAP1 DOCK2
2 actin cytoskeleton organization GO:0030036 9.16 DOCK2 NF1
3 neuron projection development GO:0031175 8.96 CNTNAP1 SH3GL2
4 myelination in peripheral nervous system GO:0022011 8.62 CNTNAP1 NF1

Sources for Childhood Pilocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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