MCID: CHL054
MIFTS: 15

Childhood Pleomorphic Rhabdomyosarcoma

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Childhood Pleomorphic Rhabdomyosarcoma

MalaCards integrated aliases for Childhood Pleomorphic Rhabdomyosarcoma:

Name: Childhood Pleomorphic Rhabdomyosarcoma 12
Pleomorphic Childhood Rhabdomyosarcoma 74
Childhood Anaplastic Rhabdomyosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7463
NCIt 51 C7959
UMLS 74 C0279614

Summaries for Childhood Pleomorphic Rhabdomyosarcoma

MalaCards based summary : Childhood Pleomorphic Rhabdomyosarcoma, is also known as pleomorphic childhood rhabdomyosarcoma. An important gene associated with Childhood Pleomorphic Rhabdomyosarcoma is ACTC1 (Actin Alpha Cardiac Muscle 1). The drugs Carboplatin and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and endothelial.

Related Diseases for Childhood Pleomorphic Rhabdomyosarcoma

Symptoms & Phenotypes for Childhood Pleomorphic Rhabdomyosarcoma

Drugs & Therapeutics for Childhood Pleomorphic Rhabdomyosarcoma

Drugs for Childhood Pleomorphic Rhabdomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
2
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
3
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
4
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
5
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
6
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
8
Histamine Approved, Investigational Phase 3 51-45-6 774
9
Cyproheptadine Approved Phase 3 129-03-3 2913
10 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
11 Immunologic Factors Phase 3,Phase 2
12 Etoposide phosphate Phase 3,Phase 2
13 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
14 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
15 Antirheumatic Agents Phase 3,Phase 2
16 Antimitotic Agents Phase 3,Phase 2
17 Anti-Infective Agents Phase 3,Phase 2
18 Antineoplastic Agents, Alkylating Phase 3,Phase 2
19 Immunosuppressive Agents Phase 3,Phase 2
20 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
21
Isophosphamide mustard Phase 3,Phase 2 0
22 Alkylating Agents Phase 3,Phase 2
23 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
24 Histamine Antagonists Phase 3
25 Neurotransmitter Agents Phase 3
26 Gastrointestinal Agents Phase 3
27 Serotonin Agents Phase 3
28 Serotonin Antagonists Phase 3
29 Anti-Allergic Agents Phase 3
30 Antipruritics Phase 3
31 Dermatologic Agents Phase 3
32 Histamine H1 Antagonists Phase 3
33
Histamine Phosphate Phase 3 51-74-1 65513
34
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
35
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
36
Bevacizumab Approved, Investigational Phase 2 216974-75-3
37
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
38
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 5284616 6436030
39
Vinorelbine Approved, Investigational Phase 2 71486-22-1 44424639 60780
40
Doxorubicin Approved, Investigational Phase 2,Phase 1 23214-92-8 31703
41
Lenograstim Approved, Investigational Phase 2 135968-09-1
42
Emodepside Investigational, Vet_approved Phase 2 155030-63-0
43
Doxil Approved June 1999 Phase 2,Phase 1 31703
44 Immunoglobulins Phase 2,Phase 1
45 Immunoglobulin G Phase 2
46 Endothelial Growth Factors Phase 2
47 Mitogens Phase 2
48 Angiogenesis Inhibitors Phase 2
49 Antibodies, Monoclonal Phase 2,Phase 1
50 Antifungal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
2 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
3 Vinorelbine Tartrate and Cyclophosphamide in Combination With Bevacizumab or Temsirolimus in Treating Patients With Recurrent or Refractory Rhabdomyosarcoma Completed NCT01222715 Phase 2 Cyclophosphamide;Temsirolimus;Vinorelbine Tartrate
4 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
5 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
6 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
7 DNA Tests in Detecting Disseminated Disease in Tumor, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma Completed NCT01419509

Search NIH Clinical Center for Childhood Pleomorphic Rhabdomyosarcoma

Genetic Tests for Childhood Pleomorphic Rhabdomyosarcoma

Anatomical Context for Childhood Pleomorphic Rhabdomyosarcoma

MalaCards organs/tissues related to Childhood Pleomorphic Rhabdomyosarcoma:

42
Bone, Testes, Endothelial, Bone Marrow

Publications for Childhood Pleomorphic Rhabdomyosarcoma

Variations for Childhood Pleomorphic Rhabdomyosarcoma

Expression for Childhood Pleomorphic Rhabdomyosarcoma

Search GEO for disease gene expression data for Childhood Pleomorphic Rhabdomyosarcoma.

Pathways for Childhood Pleomorphic Rhabdomyosarcoma

GO Terms for Childhood Pleomorphic Rhabdomyosarcoma

Sources for Childhood Pleomorphic Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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