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CHILD
MCID: CHL079
MIFTS: 27

Children's Interstitial Lung Disease (CHILD)

Categories: Rare diseases, Respiratory diseases
Tissues Related diseases Publications Drugs
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Aliases & Classifications for Children's Interstitial Lung Disease

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MalaCards integrated aliases for Children's Interstitial Lung Disease:

Name: Children's Interstitial Lung Disease 52
Primary Interstitial Lung Disease Specific to Childhood 52 58
Primary Ild Specific to Childhood 52 58
Child 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
Orphanet: 58  
Rare respiratory diseases


External Ids:

Orphanet 58 ORPHA264665
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Summaries for Children's Interstitial Lung Disease

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NIH Rare Diseases : 52 Children's interstitial and diffuse lung disease (chILD) is not a single condition, but a group of rare lung diseases found in infants, children and adolescents that can range from mild to severe . All types of chILD decrease a child's ability to supply oxygen to their body. These diseases make it difficult for the lungs to exchange oxygen and carbon dioxide and can cause fluid and other materials to collect in the lungs. Early diagnosis and treatment is important for any type of chILD. See the Children's Interstitial Lung Disease Foundation to see a list of different ILDs and to find more information about diagnosis, treatment and help finding a specialist.

MalaCards based summary : Children's Interstitial Lung Disease, also known as primary interstitial lung disease specific to childhood, is related to primary interstitial lung disease specific to childhood due to alveolar structure disorder and primary interstitial lung disease specific to childhood due to alveolar vascular disorder. The drugs Nitrazepam and Nitrous oxide have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and brain.

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Related Diseases for Children's Interstitial Lung Disease

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Diseases related to Children's Interstitial Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 primary interstitial lung disease specific to childhood due to alveolar structure disorder 11.6
2 primary interstitial lung disease specific to childhood due to alveolar vascular disorder 11.6
3 primary interstitial lung disease specific to childhood due to pulmonary surfactant protein anomalies 11.6
4 lung disease 10.6
5 interstitial lung disease 10.5
6 glycogen storage disease 10.2
7 neuroendocrine cell hyperplasia of infancy 10.2
8 pulmonary interstitial glycogenosis 10.2
9 surfactant dysfunction 10.1
10 alveolar capillary dysplasia with misalignment of pulmonary veins 9.9
11 respiratory failure 9.9
12 idiopathic interstitial pneumonia 9.9
13 pulmonary fibrosis 9.9

Graphical network of the top 20 diseases related to Children's Interstitial Lung Disease:



Diseases related to Children's Interstitial Lung Disease
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Symptoms & Phenotypes for Children's Interstitial Lung Disease

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Drugs & Therapeutics for Children's Interstitial Lung Disease

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Drugs for Children's Interstitial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1256)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitrazepam Approved Phase 4 146-22-5 4506
2
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
3
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
4
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
5
Ferrous succinate Approved Phase 4 10030-90-7
6
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
7
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
8
Vancomycin Approved Phase 4 1404-90-6 441141 14969
9
Levodopa Approved Phase 4 59-92-7 6047
10
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
11
acetic acid Approved Phase 4 64-19-7 176
12
Clobazam Approved, Illicit Phase 4 22316-47-8 2789
13
Rufinamide Approved Phase 4 106308-44-5 129228
14
Ethosuximide Approved Phase 4 77-67-8 3291
15
Stiripentol Approved Phase 4 49763-96-4
16
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
17
Zonisamide Approved, Investigational Phase 4 68291-97-4 5734
18
Cefazolin Approved Phase 4 25953-19-9 33255 656510
19
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
20
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
21
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
22
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
23
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
24
Calcium carbonate Approved, Investigational Phase 4 471-34-1
25
Azelastine Approved Phase 4 58581-89-8 2267
26
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
27 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
28
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
29
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
30
Simvastatin Approved Phase 4 79902-63-9 54454
31
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
32
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
33
Zinc Approved, Investigational Phase 4 7440-66-6 32051
34
Ferrous fumarate Approved Phase 4 141-01-5
35
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
36
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
37
Iodine Approved, Investigational Phase 4 7553-56-2 807
38
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
39
Cycloserine Approved Phase 4 68-41-7 401 6234
40
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
41
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
42
Lumefantrine Approved Phase 4 82186-77-4 6437380
43
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
44
Nelfinavir Approved Phase 4 159989-64-7 64143
45
Enoxaparin Approved Phase 4 9005-49-6 772
46
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
47
Loratadine Approved, Investigational Phase 4 79794-75-5 3957
48
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
49
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
50
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986

Interventional clinical trials:

(show top 50) (show all 9190)
# Name Status NCT ID Phase Drugs
1 Emtricitabine for Naive Child Chinese Chronic Hepatitis B Patients Unknown status NCT02327676 Phase 4 Emtricitabine
2 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
3 Children's Healthy Living Program for Remote Underserved Minority Populations in the Pacific Region Unknown status NCT01881373 Phase 4
4 A Two-site Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality in Rural Areas of Burkina Faso and Guinea-Bissau Unknown status NCT01644721 Phase 4
5 A Two-site Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality in Rural Areas of Burkina Faso and Guinea-Bissau Unknown status NCT01668745 Phase 4
6 A Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality and to Explore the Role of Maternal Measles Antibodies for the Beneficial Non-specific Effects of Measles Vaccine Unknown status NCT01486355 Phase 4
7 Child With Severe Aplastic Anemia (SAA) Therapy: the Injection of Umbilical Cord Derived Mesenchymal Stem Cells. Unknown status NCT02218437 Phase 4 MSC+ATG
8 The Impact of Reducing Overtreatment on Quality of Life in Children With Refractory Epilepsy Unknown status NCT00647322 Phase 4
9 Branched-chain Amino Acid (BCAA) on Progression of Advanced Liver Disease (BRAVE): Korean Nation-wide Multicenter Retrospective and Prospective Observational Cohort Study Unknown status NCT02837302 Phase 4 Livact
10 Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child Unknown status NCT01796132 Phase 4 SSRI/SNRI
11 Randomized, Controlled Study of Iron Supplementation of Infants With Birth Weights 2000-2500 g Unknown status NCT00558454 Phase 4 Iron
12 Cohort Prospective Study of Children With Head and Neck Cystic Malformation Who Are Treated With Intracystic OK432 Unknown status NCT01699347 Phase 4 Intracystic injection of OK432 under US guiding
13 Comparing Rapid Bronchodilatory Effect of Formoterol and Salbutamol in Children Between 5-15 Years With Mild to Moderate Acute Exacerbation of Asthma- A Double Blind Randomized Controlled Trial Unknown status NCT00900874 Phase 4 salbutamol;Formoterol
14 Clinical Study on the Effects of Propofol for Treatment on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Strabismus Surgery Unknown status NCT02738814 Phase 4 propofol
15 Effect of Dexamethasone or Clonidine When Given as Adjuncts to Ropivacaine for Caudal Analgesia on Duration of Analgesia Compared to Placebo in Children Unknown status NCT02773602 Phase 4 Dexamethasone;Clonidine;Normal Saline
16 Efficacy and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for the Treatment of Uncomplicated Malaria in Guinea-Bissau. Unknown status NCT01704508 Phase 4 Artemether-lumefantrine;Dihydroartemisinin-piperaquine
17 The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau Unknown status NCT00137566 Phase 4 acetaminophen (paracetamol)
18 Prospective Comparative Study of the Efficacy of Common Antipyretic Treatments in Febrile Children Unknown status NCT02294071 Phase 4 Ibuprofen;Acetaminophen
19 Effect of Vitamin D Supplementation in Young Children With Acute Lower Respiratory Tract Infection at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02054182 Phase 4 Vitamin D
20 Efficacy of Concerta in Treating ADHD in Mothers of Children With ADHD Unknown status NCT00318981 Phase 4 Concerta
21 Use of Silicone Gel to Improve Retroauricular Scar in Microtia Patients Unknown status NCT02518035 Phase 4 Silicone Gel
22 Efficacy of Combined Oral L-Ornithine-L-Aspartate and Oral Lactulose in Patients With Hepatic Encephalopathy Unknown status NCT00740142 Phase 4 L-ornithine-L-aspartate and lactulose;placebo and lactulose
23 Entecavir for Patients With Decompensated HBV-Related Cirrhosis:a Prospective Randomized Controlled Trial Unknown status NCT00663182 Phase 4 Entecavir
24 Evaluation of Family Intervention Program for the Treatment of Overweight or Obese Children (Nereu Program): Randomized Clinical Trial Unknown status NCT01878994 Phase 4
25 Different Doses of Anti-thymocyte Globin With 2.5 or 3.75mg/kg to Treat Child Severe Aplastic Anemia Unknown status NCT01997372 Phase 4 ATG
26 The Effect on Overall Mortality of a National Policy of Limiting Measles Vaccination to Children Below 12 Months of Age Unknown status NCT01306006 Phase 4
27 A 12-Month Open Label Safety Study of Methylphenidate Hydrochloride Extended-Release Capsules (Aptensio XR®) in Children Ages 4-5 Years Diagnosed With Attention-Deficit/Hyperactivity Disorder (ADHD) Unknown status NCT02677519 Phase 4 Aptensio XR
28 Randomized,Double-blind, Placebo Controlled Clinical Trial to Evaluate the Efficacy of the Phytotherapic Compound "Bromelin" on Acute Irritative Cough Unknown status NCT01356693 Phase 4 Bromelin;Placebo
29 Propofol and Fentanyl Versus Midazolam and Fentanyl for Sedation During Diagnostic or Therapeutic Gastrointestinal Endoscopy in Cirrhotic Patients Unknown status NCT00906139 Phase 4 Propofol;Midazolam;Fentanyl
30 Tolerance and Effect of Antipsychotics in Children and Adolescents With Psychosis- An Investigator-initiated, Phase IV, Randomised Double-blind Multi-centre Trial of the Benefits and Harms of Aripiprazole Versus Quetiapine in Children and Adolescents With Psychosis Unknown status NCT01119014 Phase 4 Aripiprazole;Quetiapine
31 Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma: a Randomized Clinical Trial. Unknown status NCT01494974 Phase 4
32 Multicenter Study Evaluating the Efficacy of Dicopeg Junior in Comparison With Lactulose for the Treatment of Functional Constipation in Children Aged 6 Months to 6 Years. A Prospective, Randomized Study. Unknown status NCT03177434 Phase 4 polyethylene glycols (PEG) 3350;Lactulose Oral Product
33 The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders Unknown status NCT03122158 Phase 4 Escitalopram
34 Healthy Opportunities for Physical Activity and Nutrition (HOP'N) After-School Project Unknown status NCT01015599 Phase 4
35 Effect of Perineural Dexmedetomidine on the ED50 Ropivacaine for Brachial Plexus Blocks in Pediatric Patients: a Randomized Trial Unknown status NCT02781246 Phase 4 perineural dexmedetomidine
36 Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island Unknown status NCT02904070 Phase 4
37 Effect of Vitamin d Supplementation on the Control of Persistent Asthma in Children at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02053402 Phase 4 Vitamin D
38 Effects of a Probiotic Supplement on Symptoms of ADHD and Anxiety in Children Unknown status NCT02545634 Phase 4
39 Randomized and Controlled Study of Endoscopic Ligation, Nadolol and Isosorbide Mononitrate vs Endoscopic Ligation and Nadolol Alone, or Associated With Isosorbide Mononitrate or Prazosin, Depending of the Hemodinamyc Response Unknown status NCT00563602 Phase 4
40 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
41 Phase 4 Study of Sarpogrelate That Prevent Contrast-induced Nephropathy Unknown status NCT01165567 Phase 4 sarpogrelate
42 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
43 Double-Blind Randomised Investigation of Tibolone Alone or in Adjunct to Standard Antidepressant Treatment for Depression in Menopausal Women Unknown status NCT01470092 Phase 4 Tibolone
44 A Multicenter Study to Evaluate the Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
45 Immunogenicity Of A Prophylactic Quadrivalent Human Papillomavirus (Types 6, 11, 16, And 18) L1 Virus-Like Particle Vaccine In Male And Female Adolescent Transplant Recipients. Unknown status NCT01101750 Phase 4
46 Oxytocin-based Pharmacotherapy for Autism Spectrum Disorders: Investigating the Neural and Behavioral Effects of a Promising Intervention Approach Unknown status NCT02940574 Phase 4 Syntocinon (Oxytocin)
47 A Comparison of Two Doses of Intranasal Dexmedetomidine for Premedication in Children - a Double- Blind Randomised Controlled Trial Unknown status NCT02459509 Phase 4 Dexmedetomidine
48 Trial of Ablation of Small Hepatocellular Carcinomas in Patients of Cirrhosis Unknown status NCT01438437 Phase 4
49 Cymbalta for Depression as a Complication of Bereavement Unknown status NCT00658931 Phase 4 Drug treatment with Cymbalta
50 Chemoembolization With or Without Antiviral Therapy for Unresectable HBV-related Hepatocellular Carcinoma With Low HBV DNA Replication: Effectiveness and Safety. A Prospective and Randomized Clinical Trial Unknown status NCT01894269 Phase 4 Lamivudine 100mg once daily; or Entecavir 0.5mg once daily.

Search NIH Clinical Center for Children's Interstitial Lung Disease

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Genetic Tests for Children's Interstitial Lung Disease

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Anatomical Context for Children's Interstitial Lung Disease

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MalaCards organs/tissues related to Children's Interstitial Lung Disease:

40
Testes, Liver, Brain, Bone, Heart, Lung, Breast
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Publications for Children's Interstitial Lung Disease

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Articles related to Children's Interstitial Lung Disease:

(show all 30)
# Title Authors PMID Year
1
One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD). 61
31748256 2019
2
Patient education for children with interstitial lung diseases and their caregivers: A pilot study. 61
30709570 2019
3
Long-Term Lung Function and Exercise Capacity in Postinfectious chILD. 61
31032143 2019
4
ChILD - Children's interstitial lung disease. 61
30519307 2018
5
The European research collaboration for Children's Interstitial Lung Disease (ChILDEU) ERS Clinical Research Collaboration. 61
30523205 2018
6
Development and validation of a health-related quality of life questionnaire for pediatric patients with interstitial lung disease. 61
29687642 2018
7
Diagnostic accuracy and therapeutic relevance of thoracoscopic lung biopsies in children. 61
29578653 2018
8
International management platform for children's interstitial lung disease (chILD-EU). 61
29056600 2018
9
Increased Risk of Interstitial Lung Disease in Children with a Single R288K Variant of ABCA3. 61
26928390 2016
10
Update on Diffuse Lung Disease in Children. 61
26502226 2016
11
Transforming growth factor-beta 1 in humidifier disinfectant-associated children's interstitial lung disease. 61
26111363 2016
12
Humidifier disinfectant-associated children's interstitial lung disease: Computed tomographic features, histopathologic correlation and comparison between survivors and non-survivors. 61
25991482 2016
13
[Modern Views on Children's Interstitial Lung Disease]. 61
26234096 2015
14
Humidifier disinfectant-associated children's interstitial lung disease. 61
24199596 2014
15
[Neuroendocrine cell hyperplasia of infancy--case study]. 61
24964239 2014
16
Diffuse lung disease in infancy and childhood: expanding the chILD classification. 61
24117670 2013
17
Interstitial lung disease in children. 61
23973003 2013
18
Inhalation toxicity of humidifier disinfectants as a risk factor of children's interstitial lung disease in Korea: a case-control study. 61
23755124 2013
19
New coding in the International Classification of Diseases, Ninth Revision, for children's interstitial lung disease. 61
22948581 2012
20
Paediatric interstitial lung disease: classification and definitions. 61
22018036 2011
21
Familial neuroendocrine cell hyperplasia of infancy. 61
20623780 2010
22
ChILD Family Education. 61
22332033 2010
23
Infants and Young Children with Children's Interstitial Lung Disease. 61
22332029 2010
24
Round Table Discussion: Children's Interstitial Lung Disease. 61
22332034 2010
25
Genetic Basis of Children's Interstitial Lung Disease. 61
22087432 2010
26
Expanding Our Understanding of Children's Interstitial Lung Disease. 61
22332027 2010
27
Serum KL-6 differentiates neuroendocrine cell hyperplasia of infancy from the inborn errors of surfactant metabolism. 61
19237389 2009
28
Evaluating infants and children with interstitial lung disease. 61
17562503 2007
29
How to evaluate and treat children's interstitial lung disease. 61
16798580 2006
30
Surfactant dysfunction mutations in children's interstitial lung disease and beyond. 61
16216835 2005
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Variations for Children's Interstitial Lung Disease

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Expression for Children's Interstitial Lung Disease

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Search GEO for disease gene expression data for Children's Interstitial Lung Disease.
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Pathways for Children's Interstitial Lung Disease

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GO Terms for Children's Interstitial Lung Disease

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Sources for Children's Interstitial Lung Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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