CHILD
MCID: CHL079
MIFTS: 27

Children's Interstitial Lung Disease (CHILD)

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Children's Interstitial Lung Disease

MalaCards integrated aliases for Children's Interstitial Lung Disease:

Name: Children's Interstitial Lung Disease 52
Primary Interstitial Lung Disease Specific to Childhood 52 58
Primary Ild Specific to Childhood 52 58
Child 52

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

Orphanet 58 ORPHA264665

Summaries for Children's Interstitial Lung Disease

NIH Rare Diseases : 52 Children's interstitial and diffuse lung disease (chILD) is not a single condition, but a group of rare lung diseases found in infants, children and adolescents that can range from mild to severe . All types of chILD decrease a child's ability to supply oxygen to their body. These diseases make it difficult for the lungs to exchange oxygen and carbon dioxide and can cause fluid and other materials to collect in the lungs. Early diagnosis and treatment is important for any type of chILD. See the Children's Interstitial Lung Disease Foundation to see a list of different ILDs and to find more information about diagnosis, treatment and help finding a specialist.

MalaCards based summary : Children's Interstitial Lung Disease, also known as primary interstitial lung disease specific to childhood, is related to primary interstitial lung disease specific to childhood due to alveolar structure disorder and primary interstitial lung disease specific to childhood due to alveolar vascular disorder. The drugs Nitrazepam and Lamotrigine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and brain.

Related Diseases for Children's Interstitial Lung Disease

Graphical network of the top 20 diseases related to Children's Interstitial Lung Disease:



Diseases related to Children's Interstitial Lung Disease

Symptoms & Phenotypes for Children's Interstitial Lung Disease

Drugs & Therapeutics for Children's Interstitial Lung Disease

Drugs for Children's Interstitial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1222)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitrazepam Approved Phase 4 146-22-5 4506
2
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
3
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
4
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
5
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
6
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
7
Vancomycin Approved Phase 4 1404-90-6 14969 441141
8
Levodopa Approved Phase 4 59-92-7 6047
9
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
10
Ethosuximide Approved Phase 4 77-67-8 3291
11
acetic acid Approved Phase 4 64-19-7 176
12
Rufinamide Approved Phase 4 106308-44-5 129228
13
Clobazam Approved, Illicit Phase 4 22316-47-8 2789
14
Stiripentol Approved Phase 4 49763-96-4
15
Cefoxitin Approved Phase 4 35607-66-0 441199
16
Cefazolin Approved Phase 4 25953-19-9 656510 33255
17
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
18
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
19
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
20
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
21
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
22
Racepinephrine Approved Phase 4 329-65-7 838
23
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
24
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
25
Lactitol Approved, Investigational Phase 4 585-88-6, 585-86-4 493591
26
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
27
Calcium carbonate Approved, Investigational Phase 4 471-34-1
28
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 2826718 468682
29
Azelastine Approved Phase 4 58581-89-8 2267
30 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
31
Simvastatin Approved Phase 4 79902-63-9 54454
32
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
33
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
34
Ferrous fumarate Approved Phase 4 141-01-5
35
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
36
Zinc Approved, Investigational Phase 4 7440-66-6 32051
37
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
38
Iodine Approved, Investigational Phase 4 7553-56-2 807
39
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
40
Cycloserine Approved Phase 4 68-41-7 401 6234
41
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
42
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
43
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
44
Lumefantrine Approved Phase 4 82186-77-4 6437380
45
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
46
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
47
Nelfinavir Approved Phase 4 159989-64-7 64143
48
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
49
Loratadine Approved, Investigational Phase 4 79794-75-5 3957
50
Valproic acid Approved, Investigational Phase 4 99-66-1 3121

Interventional clinical trials:

(show top 50) (show all 9780)
# Name Status NCT ID Phase Drugs
1 Emtricitabine for Naive Child Chinese Chronic Hepatitis B Patients Unknown status NCT02327676 Phase 4 Emtricitabine
2 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
3 Obstetrical Gel Use to Shorten Labor and Prevent Lower Genital Tract Trauma: A Randomized Controlled Trial Unknown status NCT03518684 Phase 4 Natalis
4 A Two-site Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality in Rural Areas of Burkina Faso and Guinea-Bissau Unknown status NCT01668745 Phase 4
5 A Two-site Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality in Rural Areas of Burkina Faso and Guinea-Bissau Unknown status NCT01644721 Phase 4
6 Assessment of Intellectual, Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Pregnancy Unknown status NCT01779817 Phase 4
7 Child With Severe Aplastic Anemia (SAA) Therapy: the Injection of Umbilical Cord Derived Mesenchymal Stem Cells. Unknown status NCT02218437 Phase 4 MSC+ATG
8 The Impact of Reducing Overtreatment on Quality of Life in Children With Refractory Epilepsy Unknown status NCT00647322 Phase 4
9 A Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality and to Explore the Role of Maternal Measles Antibodies for the Beneficial Non-specific Effects of Measles Vaccine Unknown status NCT01486355 Phase 4
10 Branched-chain Amino Acid (BCAA) on Progression of Advanced Liver Disease (BRAVE): Korean Nation-wide Multicenter Retrospective and Prospective Observational Cohort Study Unknown status NCT02837302 Phase 4 Livact
11 Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child Unknown status NCT01796132 Phase 4 SSRI/SNRI
12 Discoloration of Carious Primary Teeth After Application of Silver Diamine Fluoride Versus Sodium Fluoride Varnish: A Randomized Clinical Trial Unknown status NCT03557996 Phase 4 Silver Diamine Fluoride;Sodium Fluoride Varnish
13 Effect of Dexamethasone or Clonidine When Given as Adjuncts to Ropivacaine for Caudal Analgesia on Duration of Analgesia Compared to Placebo in Children Unknown status NCT02773602 Phase 4 Dexamethasone;Clonidine;Normal Saline
14 Clinical Study on the Effects of Propofol for Treatment on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Strabismus Surgery Unknown status NCT02738814 Phase 4 propofol
15 Cohort Prospective Study of Children With Head and Neck Cystic Malformation Who Are Treated With Intracystic OK432 Unknown status NCT01699347 Phase 4 Intracystic injection of OK432 under US guiding
16 Comparing Rapid Bronchodilatory Effect of Formoterol and Salbutamol in Children Between 5-15 Years With Mild to Moderate Acute Exacerbation of Asthma- A Double Blind Randomized Controlled Trial Unknown status NCT00900874 Phase 4 salbutamol;Formoterol
17 Efficacy and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for the Treatment of Uncomplicated Malaria in Guinea-Bissau. Unknown status NCT01704508 Phase 4 Artemether-lumefantrine;Dihydroartemisinin-piperaquine
18 The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau Unknown status NCT00137566 Phase 4 acetaminophen (paracetamol)
19 Effect of Vitamin D Supplementation in Young Children With Acute Lower Respiratory Tract Infection at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02054182 Phase 4 Vitamin D
20 Use of Silicone Gel to Improve Retroauricular Scar in Microtia Patients Unknown status NCT02518035 Phase 4 Silicone Gel
21 Efficacy of Concerta in Treating ADHD in Mothers of Children With ADHD Unknown status NCT00318981 Phase 4 Concerta
22 Prospective Comparative Study of the Efficacy of Common Antipyretic Treatments in Febrile Children Unknown status NCT02294071 Phase 4 Ibuprofen;Acetaminophen
23 Different Doses of Anti-thymocyte Globin With 2.5 or 3.75mg/kg to Treat Child Severe Aplastic Anemia Unknown status NCT01997372 Phase 4 ATG
24 Evaluation of Family Intervention Program for the Treatment of Overweight or Obese Children (Nereu Program): Randomized Clinical Trial Unknown status NCT01878994 Phase 4
25 Randomized,Double-blind, Placebo Controlled Clinical Trial to Evaluate the Efficacy of the Phytotherapic Compound "Bromelin" on Acute Irritative Cough Unknown status NCT01356693 Phase 4 Bromelin;Placebo
26 Tolerance and Effect of Antipsychotics in Children and Adolescents With Psychosis- An Investigator-initiated, Phase IV, Randomised Double-blind Multi-centre Trial of the Benefits and Harms of Aripiprazole Versus Quetiapine in Children and Adolescents With Psychosis Unknown status NCT01119014 Phase 4 Aripiprazole;Quetiapine
27 The Effect on Overall Mortality of a National Policy of Limiting Measles Vaccination to Children Below 12 Months of Age Unknown status NCT01306006 Phase 4
28 Efficacy of Combined Oral L-Ornithine-L-Aspartate and Oral Lactulose in Patients With Hepatic Encephalopathy Unknown status NCT00740142 Phase 4 L-ornithine-L-aspartate and lactulose;placebo and lactulose
29 A 12-Month Open Label Safety Study of Methylphenidate Hydrochloride Extended-Release Capsules (Aptensio XR®) in Children Ages 4-5 Years Diagnosed With Attention-Deficit/Hyperactivity Disorder (ADHD) Unknown status NCT02677519 Phase 4 Aptensio XR
30 Entecavir for Patients With Decompensated HBV-Related Cirrhosis:a Prospective Randomized Controlled Trial Unknown status NCT00663182 Phase 4 Entecavir
31 Propofol and Fentanyl Versus Midazolam and Fentanyl for Sedation During Diagnostic or Therapeutic Gastrointestinal Endoscopy in Cirrhotic Patients Unknown status NCT00906139 Phase 4 Propofol;Midazolam;Fentanyl
32 Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma: a Randomized Clinical Trial. Unknown status NCT01494974 Phase 4
33 Multicenter Study Evaluating the Efficacy of Dicopeg Junior in Comparison With Lactulose for the Treatment of Functional Constipation in Children Aged 6 Months to 6 Years. A Prospective, Randomized Study. Unknown status NCT03177434 Phase 4 polyethylene glycols (PEG) 3350;Lactulose Oral Product
34 The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders Unknown status NCT03122158 Phase 4 Escitalopram
35 Healthy Opportunities for Physical Activity and Nutrition (HOP'N) After-School Project Unknown status NCT01015599 Phase 4
36 Effect of Perineural Dexmedetomidine on the ED50 Ropivacaine for Brachial Plexus Blocks in Pediatric Patients: a Randomized Trial Unknown status NCT02781246 Phase 4 perineural dexmedetomidine
37 Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island Unknown status NCT02904070 Phase 4
38 Effects of a Probiotic Supplement on Symptoms of ADHD and Anxiety in Children Unknown status NCT02545634 Phase 4
39 Effect of Vitamin d Supplementation on the Control of Persistent Asthma in Children at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02053402 Phase 4 Vitamin D
40 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
41 Randomized and Controlled Study of Endoscopic Ligation, Nadolol and Isosorbide Mononitrate vs Endoscopic Ligation and Nadolol Alone, or Associated With Isosorbide Mononitrate or Prazosin, Depending of the Hemodinamyc Response Unknown status NCT00563602 Phase 4
42 Phase 4 Study of Sarpogrelate That Prevent Contrast-induced Nephropathy Unknown status NCT01165567 Phase 4 sarpogrelate
43 Phase4, to Assess Time to Progression (TTP) and Safety Profile of Doxorubicin-Eluting-Bead Embolization(DEBDOX) in Patients With Advanced HCC Unknown status NCT02525380 Phase 4
44 The Protective Effect of the α2-agonist Dexmedetomidine on Mitochondrial Structure and Function for Children With Non-cyanotic Congenital Heart Defects Having Cardiac Surgery: A Randomized Controlled Trial. Unknown status NCT02299063 Phase 4 Dexmedetomidine;0.9% NaCl
45 The Effect of Probiotics on Asthma Risk in Animal Laboratory Workers: A Randomized Controlled Trial. Unknown status NCT03021161 Phase 4 Probiotic Formula
46 A Multicenter Study to Evaluate the Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
47 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
48 Immunogenicity Of A Prophylactic Quadrivalent Human Papillomavirus (Types 6, 11, 16, And 18) L1 Virus-Like Particle Vaccine In Male And Female Adolescent Transplant Recipients. Unknown status NCT01101750 Phase 4
49 A Comparison of Two Doses of Intranasal Dexmedetomidine for Premedication in Children - a Double- Blind Randomised Controlled Trial Unknown status NCT02459509 Phase 4 Dexmedetomidine
50 Chemoembolization With or Without Antiviral Therapy for Unresectable HBV-related Hepatocellular Carcinoma With Low HBV DNA Replication: Effectiveness and Safety. A Prospective and Randomized Clinical Trial Unknown status NCT01894269 Phase 4 Lamivudine 100mg once daily; or Entecavir 0.5mg once daily.

Search NIH Clinical Center for Children's Interstitial Lung Disease

Genetic Tests for Children's Interstitial Lung Disease

Anatomical Context for Children's Interstitial Lung Disease

MalaCards organs/tissues related to Children's Interstitial Lung Disease:

40
Testes, Liver, Brain, Bone, Heart, Lung, Breast

Publications for Children's Interstitial Lung Disease

Articles related to Children's Interstitial Lung Disease:

(show all 31)
# Title Authors PMID Year
1
Overview of the ChILD Research Network: A roadmap for progress and success in defining rare diseases. 61
32533913 2020
2
One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD). 61
31748256 2020
3
Patient education for children with interstitial lung diseases and their caregivers: A pilot study. 61
30709570 2019
4
Long-Term Lung Function and Exercise Capacity in Postinfectious chILD. 61
31032143 2019
5
ChILD - Children's interstitial lung disease. 61
30519307 2018
6
The European research collaboration for Children's Interstitial Lung Disease (ChILDEU) ERS Clinical Research Collaboration. 61
30523205 2018
7
Development and validation of a health-related quality of life questionnaire for pediatric patients with interstitial lung disease. 61
29687642 2018
8
Diagnostic accuracy and therapeutic relevance of thoracoscopic lung biopsies in children. 61
29578653 2018
9
International management platform for children's interstitial lung disease (chILD-EU). 61
29056600 2018
10
Increased Risk of Interstitial Lung Disease in Children with a Single R288K Variant of ABCA3. 61
26928390 2016
11
Update on Diffuse Lung Disease in Children. 61
26502226 2016
12
Transforming growth factor-beta 1 in humidifier disinfectant-associated children's interstitial lung disease. 61
26111363 2016
13
Humidifier disinfectant-associated children's interstitial lung disease: Computed tomographic features, histopathologic correlation and comparison between survivors and non-survivors. 61
25991482 2016
14
[Modern Views on Children's Interstitial Lung Disease]. 61
26234096 2015
15
Humidifier disinfectant-associated children's interstitial lung disease. 61
24199596 2014
16
[Neuroendocrine cell hyperplasia of infancy--case study]. 61
24964239 2014
17
Diffuse lung disease in infancy and childhood: expanding the chILD classification. 61
24117670 2013
18
Interstitial lung disease in children. 61
23973003 2013
19
Inhalation toxicity of humidifier disinfectants as a risk factor of children's interstitial lung disease in Korea: a case-control study. 61
23755124 2013
20
New coding in the International Classification of Diseases, Ninth Revision, for children's interstitial lung disease. 61
22948581 2012
21
Paediatric interstitial lung disease: classification and definitions. 61
22018036 2011
22
Familial neuroendocrine cell hyperplasia of infancy. 61
20623780 2010
23
ChILD Family Education. 61
22332033 2010
24
Infants and Young Children with Children's Interstitial Lung Disease. 61
22332029 2010
25
Round Table Discussion: Children's Interstitial Lung Disease. 61
22332034 2010
26
Genetic Basis of Children's Interstitial Lung Disease. 61
22087432 2010
27
Expanding Our Understanding of Children's Interstitial Lung Disease. 61
22332027 2010
28
Serum KL-6 differentiates neuroendocrine cell hyperplasia of infancy from the inborn errors of surfactant metabolism. 61
19237389 2009
29
Evaluating infants and children with interstitial lung disease. 61
17562503 2007
30
How to evaluate and treat children's interstitial lung disease. 61
16798580 2006
31
Surfactant dysfunction mutations in children's interstitial lung disease and beyond. 61
16216835 2005

Variations for Children's Interstitial Lung Disease

Expression for Children's Interstitial Lung Disease

Search GEO for disease gene expression data for Children's Interstitial Lung Disease.

Pathways for Children's Interstitial Lung Disease

GO Terms for Children's Interstitial Lung Disease

Sources for Children's Interstitial Lung Disease

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61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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