Children's Interstitial Lung Disease (CHILD)

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Children's Interstitial Lung Disease

MalaCards integrated aliases for Children's Interstitial Lung Disease:

Name: Children's Interstitial Lung Disease 20
Primary Interstitial Lung Disease Specific to Childhood 20 58
Primary Ild Specific to Childhood 20 58
Child 20


Orphanet: 58  
Rare respiratory diseases

External Ids:

Orphanet 58 ORPHA264665

Summaries for Children's Interstitial Lung Disease

GARD : 20 Children's interstitial and diffuse lung disease (chILD) is not a single condition, but a group of rare lung diseases found in infants, children and adolescents that can range from mild to severe. All types of chILD decrease a child's ability to supply oxygen to their body. These diseases make it difficult for the lungs to exchange oxygen and carbon dioxide and can cause fluid and other materials to collect in the lungs. Early diagnosis and treatment is important for any type of chILD. See the Children's Interstitial Lung Disease Foundation to see a list of different ILDs and to find more information about diagnosis, treatment and help finding a specialist.

MalaCards based summary : Children's Interstitial Lung Disease, also known as primary interstitial lung disease specific to childhood, is related to primary interstitial lung disease specific to childhood due to alveolar structure disorder and primary interstitial lung disease specific to childhood due to alveolar vascular disorder. The drugs Valproic acid and Phenytoin have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone.

Related Diseases for Children's Interstitial Lung Disease

Graphical network of the top 20 diseases related to Children's Interstitial Lung Disease:

Diseases related to Children's Interstitial Lung Disease

Symptoms & Phenotypes for Children's Interstitial Lung Disease

Drugs & Therapeutics for Children's Interstitial Lung Disease

Drugs for Children's Interstitial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 715)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
Citalopram Approved Phase 4 59729-33-8 2771
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
Sargramostim Approved, Investigational Phase 4 123774-72-1, 83869-56-1
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
Nitrazepam Approved Phase 4 146-22-5 4506
Clobazam Approved, Illicit Phase 4 22316-47-8 2789
Rufinamide Approved Phase 4 106308-44-5 129228
Vigabatrin Approved Phase 4 60643-86-9, 68506-86-5 5665
Stiripentol Approved Phase 4 49763-96-4
Topiramate Approved Phase 4 97240-79-4 5284627
Levetiracetam Approved Phase 4 102767-28-2 441341
Ethosuximide Approved Phase 4 77-67-8 3291
Zonisamide Approved, Investigational Phase 4 68291-97-4 5734
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
Lopinavir Approved Phase 4 192725-17-0 92727
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
Nevirapine Approved Phase 4 129618-40-2 4463
Zidovudine Approved Phase 4 30516-87-1 35370
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
Calcium carbonate Approved, Investigational Phase 4 471-34-1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
Sodium citrate Approved, Investigational Phase 4 68-04-2
Piperazine Approved, Vet_approved Phase 4 110-85-0 4837
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
Sulfamethoxazole Approved Phase 4 723-46-6 5329
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585 135398745
Metformin Approved Phase 4 657-24-9 14219 4091
Ferrous succinate Approved Phase 4 10030-90-7
Perphenazine Approved Phase 4 58-39-9 4748
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
Racepinephrine Approved Phase 4 329-65-7 838
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
Promethazine Approved, Investigational Phase 4 60-87-7 4927
Indomethacin Approved, Investigational Phase 4 53-86-1 3715

Interventional clinical trials:

(show top 50) (show all 3496)
# Name Status NCT ID Phase Drugs
1 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
2 The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders Unknown status NCT03122158 Phase 4 Escitalopram
3 Comparison of Effect of Peritonsillar Infiltration of Ketamine and Tramadol on Pediatric Posttonsillectomy Pain: A Double-blinded Randomized Placebo-controlled Clinical Trial Unknown status NCT03067103 Phase 4 Tramadol;Ketamine;Placebos
4 Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children Unknown status NCT00494624 Phase 4 prednisolone
5 Obstetrical Gel and Its Impact in Shortening the Duration of Labor in Women Undergoing a Vaginal Birth After Cesarean (VBAC):a Randomized Controlled Trial Unknown status NCT03751553 Phase 4 obsteric gel(k-Y jelly)
6 Effectiveness Trial of Day-care Versus Usual Care Management of Severe Pneumonia With or Without Malnutrition in Children Using the Existing Health System of Bangladesh Unknown status NCT02669654 Phase 4
7 Clinical Study on the Effects of Propofol for Treatment on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Strabismus Surgery Unknown status NCT02738814 Phase 4 propofol
8 Different Doses of Anti-thymocyte Globin With 2.5 or 3.75mg/kg to Treat Child Severe Aplastic Anemia Unknown status NCT01997372 Phase 4 ATG
9 Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child Unknown status NCT01796132 Phase 4 SSRI/SNRI
10 A Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality and to Explore the Role of Maternal Measles Antibodies for the Beneficial Non-specific Effects of Measles Vaccine Unknown status NCT01486355 Phase 4
11 A Two-site Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality in Rural Areas of Burkina Faso and Guinea-Bissau Unknown status NCT01668745 Phase 4
12 A Two-site Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality in Rural Areas of Burkina Faso and Guinea-Bissau Unknown status NCT01644721 Phase 4
13 Emtricitabine for Naive Child Chinese Chronic Hepatitis B Patients Unknown status NCT02327676 Phase 4 Emtricitabine
14 Child With Severe Aplastic Anemia (SAA) Therapy: the Injection of Umbilical Cord Derived Mesenchymal Stem Cells. Unknown status NCT02218437 Phase 4 MSC+ATG
15 Effect of Perineural Dexmedetomidine on the ED50 Ropivacaine for Brachial Plexus Blocks in Pediatric Patients: a Randomized Trial Unknown status NCT02781246 Phase 4 perineural dexmedetomidine
16 Consumption Effect of Probiotic Products on Salivary Cariogenic Bacterial Counts in Preschool Children. Unknown status NCT02692625 Phase 4
17 Effects of Functional Electrical Stimulation on Gait in Children With Hemiplegic and Diplegic Cerebral Palsy Unknown status NCT02462018 Phase 4
18 A Randomised Controlled Trial of the Ketogenic Diet in the Treatment of Epilepsy in Children Under the Age of Two Years Unknown status NCT02205931 Phase 4 Antiepileptic drug therapy
19 A Phase IV,Multi-Center,Open-Label,Unrandomized Study to Evaluate the Persistence of Antibody Response to N.Meningitidis Group C,Before & After 2 Doses of the Conjugate Pneumococcal Vaccine,in Children Seven Months & Older Who Previously Received Immunization With Chiron Meningococcal C Conjugate Vaccine & a Hexavalent Infant Vaccine According to the Applicable Infant Immunization Schedule Completed NCT00316654 Phase 4
20 Comparison of Hospital Admission Rates and Plasma(s)-Albuterol Levels in Children Treated With Racemic Albuterol Versus Levalbuterol for Acute Asthma Exacerbations: A Randomized Double-Blind Clinical Trial Completed NCT00585039 Phase 4 xopenex
21 The Effect of Dexmedetomidine as an Adjuvant to General Anesthesia on Intelligence Development in Pediatric Patients Undergoing Craniotomy: a Randomized, Double-blind and Placebo-controlled Pilot Trial Completed NCT02810899 Phase 4 dexmedetomidine;normal saline
22 Vitamin D and Genetics in Nutritional Rickets Completed NCT00949832 Phase 4
23 A Comparison of Effectiveness of Pudendal Nerve Block vs Caudal Block for Hypospadias Surgery in Children Completed NCT02390388 Phase 4
24 The Effect of Oral Dexmedetomidine Premedication On Preoperative Cooperation and Emergence Delirium In Children Undergoing Dental Treatment Completed NCT03174678 Phase 4 Dexmedetomidine
25 Stimulant and Risperidone in Children With Severe Physical Aggression Completed NCT00796302 Phase 4 Methylphenidate HCl;Risperidone;Placebo
26 Delivery of Iron and Zinc Supplements: Evaluation of Interaction Effect on Biochemical and Clinical Outcomes Completed NCT00470158 Phase 4
27 Universal Versus Conditional Three-day Follow-up Visit for Children With Unclassified Fever at the Community Level: A Study to be Conducted in Ethiopia Completed NCT02926625 Phase 4
28 Methylphenidate Study in Young Children With Developmental Disorders Completed NCT00517504 Phase 4 Methylphenidate
29 Obstetrical Gel Use to Shorten Labor and Prevent Lower Genital Tract Trauma: A Randomized Controlled Trial Completed NCT03518684 Phase 4 Natalis
30 Atomoxetine Pilot Study in Preschool Children With ADHD Completed NCT00517647 Phase 4 ATMX
31 The Effect of a Cash Transfer Program and Preventive Nutrition Packages on Household Welfare and Child Nutritional Status in Mali Completed NCT02858011 Phase 4
32 The Efficacy OF Oral DexmedetomidineVersus Oral Midazolam/Ketamine ON Parental Separation AND Face Mask Acceptance IN Pediatrics Undergoing Adenotonsillectomy Completed NCT03551067 Phase 4 Dexmedetomidine
33 Reading ICARD: Interventions for Children With Attention and Reading Disorders Completed NCT01133847 Phase 4 Methylphenidate;Mixed Salt Amphetamine;Atomoxetine;Guanfacine
34 Efficacy of Breast Milk Expressed Versus Sucrose Relief Procedural Pain of Venipuncture in Preterm. Completed NCT02133716 Phase 4
35 Adolescent Family-Based Alcohol Prevention Completed NCT00858065 Phase 4
36 A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children Completed NCT02435069 Phase 4 Dose Response - NS and USP Glycerin - First Intervention;Effectiveness - NS and USP Glycerin - Second Intervention
37 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. A Controlled and Randomized Clinical Trial. Completed NCT03642353 Phase 4 Triclosan;Placebo
38 Prospective Randomized Study of Immune Response to Licensed Influenza Vaccines in Children and Adolescents Completed NCT02250274 Phase 4
39 Use of Metoclopramide for the Prevention of Gastroesophageal Reflux in Premature Infants Followed in an Outpatient Kangaroo Mother Care Clinic Before 40 Weeks of Gestational Age: A Randomized Controlled Trial Completed NCT02907632 Phase 4 Metoclopramide;Placebo
40 Home Care Management of Pediatric Pain Completed NCT00251628 Phase 4
41 Ondansetron Administration to Children With Gastroenteritis, Vomiting and SOME Dehydration in Emergency Departments in Pakistan Completed NCT01870648 Phase 4 Ondansetron;Placebo
42 Ondansetron Administration to WELL Children With Gastroenteritis Associated Vomiting in Emergency Departments in Pakistan Completed NCT01870635 Phase 4 Ondansetron;Placebo
43 Media Use in Preschooler Study (MUPS) An Office Based Intervention to Improve Media Use in Preschool Children: a Randomized Controlled Trial Completed NCT00959309 Phase 4
44 Pilot Study of the Effect of Aripiprazole Treatment in Autism Spectrum Disorders on Functional Magnetic Resonance Imaging (fMRI) Activation Patterns and Symptoms Completed NCT01028820 Phase 4 Aripiprazole
45 Guanfacine for the Treatment of Hyperactivity in Pervasive Developmental Disorder Completed NCT01238575 Phase 4 extended-release guanfacine
46 Metabolic Effects of Antipsychotics in Children Completed NCT00205699 Phase 4 risperidone;olanzapine;aripiprazole
47 A Study of Memantine Hydrochloride (Namenda®) for Cognitive and Behavioral Impairment in Adults With Autism Spectrum Disorders Completed NCT01333865 Phase 4 Memantine
48 Open-Label Treatment Trial to Assess the Short-Term Tolerability, Safety, and Efficacy of Methylphenidate Hydrochloride Extended-Release Liquid Formulation in High-Functioning Autism Spectrum Disorder Adults With Attention-Deficit/Hyperactivity Disorder Completed NCT02096952 Phase 4 Methylphenidate extended-release liquid formulation
49 Randomized, Controlled Study of Iron Supplementation of Infants With Birth Weights 2000-2500 g Completed NCT00558454 Phase 4 Iron
50 Improving Driving in Young People With Autism Spectrum Disorders Completed NCT03538431 Phase 4 Buspirone

Search NIH Clinical Center for Children's Interstitial Lung Disease

Genetic Tests for Children's Interstitial Lung Disease

Anatomical Context for Children's Interstitial Lung Disease

MalaCards organs/tissues related to Children's Interstitial Lung Disease:

Lung, Liver, Bone, Skin, Eye, Heart, Bone Marrow

Publications for Children's Interstitial Lung Disease

Articles related to Children's Interstitial Lung Disease:

(show all 33)
# Title Authors PMID Year
Pediatric pulmonology 2019 year in review: rare and diffuse lung disease. 61
33559960 2021
Pulmonary function testing in children's interstitial lung disease. 61
32699025 2020
Overview of the ChILD Research Network: A roadmap for progress and success in defining rare diseases. 61
32533913 2020
One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD). 61
31748256 2020
Patient education for children with interstitial lung diseases and their caregivers: A pilot study. 61
30709570 2019
Long-Term Lung Function and Exercise Capacity in Postinfectious chILD. 61
31032143 2019
The European research collaboration for Children's Interstitial Lung Disease (ChILDEU) ERS Clinical Research Collaboration. 61
30523205 2018
ChILD - Children's interstitial lung disease. 61
30519307 2018
Development and validation of a health-related quality of life questionnaire for pediatric patients with interstitial lung disease. 61
29687642 2018
Diagnostic accuracy and therapeutic relevance of thoracoscopic lung biopsies in children. 61
29578653 2018
International management platform for children's interstitial lung disease (chILD-EU). 61
29056600 2018
Increased Risk of Interstitial Lung Disease in Children with a Single R288K Variant of ABCA3. 61
26928390 2016
Update on Diffuse Lung Disease in Children. 61
26502226 2016
Transforming growth factor-beta 1 in humidifier disinfectant-associated children's interstitial lung disease. 61
26111363 2016
Humidifier disinfectant-associated children's interstitial lung disease: Computed tomographic features, histopathologic correlation and comparison between survivors and non-survivors. 61
25991482 2016
[Modern Views on Children's Interstitial Lung Disease]. 61
26234096 2015
Humidifier disinfectant-associated children's interstitial lung disease. 61
24199596 2014
[Neuroendocrine cell hyperplasia of infancy--case study]. 61
24964239 2014
Diffuse lung disease in infancy and childhood: expanding the chILD classification. 61
24117670 2013
Interstitial lung disease in children. 61
23973003 2013
Inhalation toxicity of humidifier disinfectants as a risk factor of children's interstitial lung disease in Korea: a case-control study. 61
23755124 2013
New coding in the International Classification of Diseases, Ninth Revision, for children's interstitial lung disease. 61
22948581 2012
Paediatric interstitial lung disease: classification and definitions. 61
22018036 2011
Familial neuroendocrine cell hyperplasia of infancy. 61
20623780 2010
ChILD Family Education. 61
22332033 2010
Genetic Basis of Children's Interstitial Lung Disease. 61
22087432 2010
Infants and Young Children with Children's Interstitial Lung Disease. 61
22332029 2010
Expanding Our Understanding of Children's Interstitial Lung Disease. 61
22332027 2010
Round Table Discussion: Children's Interstitial Lung Disease. 61
22332034 2010
Serum KL-6 differentiates neuroendocrine cell hyperplasia of infancy from the inborn errors of surfactant metabolism. 61
19237389 2009
Evaluating infants and children with interstitial lung disease. 61
17562503 2007
How to evaluate and treat children's interstitial lung disease. 61
16798580 2006
Surfactant dysfunction mutations in children's interstitial lung disease and beyond. 61
16216835 2005

Variations for Children's Interstitial Lung Disease

Expression for Children's Interstitial Lung Disease

Search GEO for disease gene expression data for Children's Interstitial Lung Disease.

Pathways for Children's Interstitial Lung Disease

GO Terms for Children's Interstitial Lung Disease

Sources for Children's Interstitial Lung Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
70 Tocris
72 UMLS via Orphanet
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