Children's Interstitial Lung Disease (CHILD)

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Children's Interstitial Lung Disease

MalaCards integrated aliases for Children's Interstitial Lung Disease:

Name: Children's Interstitial Lung Disease 52
Primary Interstitial Lung Disease Specific to Childhood 52 58
Primary Ild Specific to Childhood 52 58
Child 52


Orphanet: 58  
Rare respiratory diseases

External Ids:

Orphanet 58 ORPHA264665

Summaries for Children's Interstitial Lung Disease

NIH Rare Diseases : 52 Children's interstitial and diffuse lung disease (chILD) is not a single condition, but a group of rare lung diseases found in infants, children and adolescents that can range from mild to severe . All types of chILD decrease a child's ability to supply oxygen to their body. These diseases make it difficult for the lungs to exchange oxygen and carbon dioxide and can cause fluid and other materials to collect in the lungs. Early diagnosis and treatment is important for any type of chILD. See the Children's Interstitial Lung Disease Foundation to see a list of different ILDs and to find more information about diagnosis, treatment and help finding a specialist.

MalaCards based summary : Children's Interstitial Lung Disease, also known as primary interstitial lung disease specific to childhood, is related to primary interstitial lung disease specific to childhood due to alveolar structure disorder and primary interstitial lung disease specific to childhood due to alveolar vascular disorder. The drugs Nitrazepam and Nitrous oxide have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and brain.

Related Diseases for Children's Interstitial Lung Disease

Graphical network of the top 20 diseases related to Children's Interstitial Lung Disease:

Diseases related to Children's Interstitial Lung Disease

Symptoms & Phenotypes for Children's Interstitial Lung Disease

Drugs & Therapeutics for Children's Interstitial Lung Disease

Drugs for Children's Interstitial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1249)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Nitrazepam Approved Phase 4 146-22-5 4506
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
Ferrous succinate Approved Phase 4 10030-90-7
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
Vancomycin Approved Phase 4 1404-90-6 441141 14969
Levodopa Approved Phase 4 59-92-7 6047
Reboxetine Approved, Experimental Phase 4 71620-89-8, 98769-81-4 123628 65856
acetic acid Approved Phase 4 64-19-7 176
Rufinamide Approved Phase 4 106308-44-5 129228
Zonisamide Approved, Investigational Phase 4 68291-97-4 5734
Clobazam Approved, Illicit Phase 4 22316-47-8 2789
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
Ethosuximide Approved Phase 4 77-67-8 3291
Stiripentol Approved Phase 4 49763-96-4
Cefazolin Approved Phase 4 25953-19-9 656510 33255
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
Racepinephrine Approved Phase 4 329-65-7 838
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
Calcium carbonate Approved, Investigational Phase 4 471-34-1
Azelastine Approved Phase 4 58581-89-8 2267
28 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 468682 2826718
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
Simvastatin Approved Phase 4 79902-63-9 54454
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
Ferrous fumarate Approved Phase 4 141-01-5
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
Iodine Approved, Investigational Phase 4 7553-56-2 807
Cycloserine Approved Phase 4 68-41-7 401 6234
Sertraline Approved Phase 4 79617-96-2 68617
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
Lumefantrine Approved Phase 4 82186-77-4 6437380
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Nelfinavir Approved Phase 4 159989-64-7 64143
Loratadine Approved, Investigational Phase 4 79794-75-5 3957
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
Enoxaparin Approved Phase 4 9005-49-6 772

Interventional clinical trials:

(show top 50) (show all 9190)
# Name Status NCT ID Phase Drugs
1 Emtricitabine for Naive Child Chinese Chronic Hepatitis B Patients Unknown status NCT02327676 Phase 4 Emtricitabine
2 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
3 Children's Healthy Living Program for Remote Underserved Minority Populations in the Pacific Region Unknown status NCT01881373 Phase 4
4 A Two-site Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality in Rural Areas of Burkina Faso and Guinea-Bissau Unknown status NCT01668745 Phase 4
5 A Two-site Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality in Rural Areas of Burkina Faso and Guinea-Bissau Unknown status NCT01644721 Phase 4
6 Branched-chain Amino Acid (BCAA) on Progression of Advanced Liver Disease (BRAVE): Korean Nation-wide Multicenter Retrospective and Prospective Observational Cohort Study Unknown status NCT02837302 Phase 4 Livact
7 Child With Severe Aplastic Anemia (SAA) Therapy: the Injection of Umbilical Cord Derived Mesenchymal Stem Cells. Unknown status NCT02218437 Phase 4 MSC+ATG
8 A Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality and to Explore the Role of Maternal Measles Antibodies for the Beneficial Non-specific Effects of Measles Vaccine Unknown status NCT01486355 Phase 4
9 The Impact of Reducing Overtreatment on Quality of Life in Children With Refractory Epilepsy Unknown status NCT00647322 Phase 4
10 Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child Unknown status NCT01796132 Phase 4 SSRI/SNRI
11 Randomized, Controlled Study of Iron Supplementation of Infants With Birth Weights 2000-2500 g Unknown status NCT00558454 Phase 4 Iron
12 Cohort Prospective Study of Children With Head and Neck Cystic Malformation Who Are Treated With Intracystic OK432 Unknown status NCT01699347 Phase 4 Intracystic injection of OK432 under US guiding
13 Comparing Rapid Bronchodilatory Effect of Formoterol and Salbutamol in Children Between 5-15 Years With Mild to Moderate Acute Exacerbation of Asthma- A Double Blind Randomized Controlled Trial Unknown status NCT00900874 Phase 4 salbutamol;Formoterol
14 Effect of Dexamethasone or Clonidine When Given as Adjuncts to Ropivacaine for Caudal Analgesia on Duration of Analgesia Compared to Placebo in Children Unknown status NCT02773602 Phase 4 Dexamethasone;Clonidine;Normal Saline
15 Clinical Study on the Effects of Propofol for Treatment on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Strabismus Surgery Unknown status NCT02738814 Phase 4 propofol
16 Efficacy and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for the Treatment of Uncomplicated Malaria in Guinea-Bissau. Unknown status NCT01704508 Phase 4 Artemether-lumefantrine;Dihydroartemisinin-piperaquine
17 The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau Unknown status NCT00137566 Phase 4 acetaminophen (paracetamol)
18 Effect of Vitamin D Supplementation in Young Children With Acute Lower Respiratory Tract Infection at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02054182 Phase 4 Vitamin D
19 Prospective Comparative Study of the Efficacy of Common Antipyretic Treatments in Febrile Children Unknown status NCT02294071 Phase 4 Ibuprofen;Acetaminophen
20 Use of Silicone Gel to Improve Retroauricular Scar in Microtia Patients Unknown status NCT02518035 Phase 4 Silicone Gel
21 Efficacy of Concerta in Treating ADHD in Mothers of Children With ADHD Unknown status NCT00318981 Phase 4 Concerta
22 Evaluation of Family Intervention Program for the Treatment of Overweight or Obese Children (Nereu Program): Randomized Clinical Trial Unknown status NCT01878994 Phase 4
23 Efficacy of Combined Oral L-Ornithine-L-Aspartate and Oral Lactulose in Patients With Hepatic Encephalopathy Unknown status NCT00740142 Phase 4 L-ornithine-L-aspartate and lactulose;placebo and lactulose
24 Different Doses of Anti-thymocyte Globin With 2.5 or 3.75mg/kg to Treat Child Severe Aplastic Anemia Unknown status NCT01997372 Phase 4 ATG
25 Randomized,Double-blind, Placebo Controlled Clinical Trial to Evaluate the Efficacy of the Phytotherapic Compound "Bromelin" on Acute Irritative Cough Unknown status NCT01356693 Phase 4 Bromelin;Placebo
26 Propofol and Fentanyl Versus Midazolam and Fentanyl for Sedation During Diagnostic or Therapeutic Gastrointestinal Endoscopy in Cirrhotic Patients Unknown status NCT00906139 Phase 4 Propofol;Midazolam;Fentanyl
27 Tolerance and Effect of Antipsychotics in Children and Adolescents With Psychosis- An Investigator-initiated, Phase IV, Randomised Double-blind Multi-centre Trial of the Benefits and Harms of Aripiprazole Versus Quetiapine in Children and Adolescents With Psychosis Unknown status NCT01119014 Phase 4 Aripiprazole;Quetiapine
28 Entecavir for Patients With Decompensated HBV-Related Cirrhosis:a Prospective Randomized Controlled Trial Unknown status NCT00663182 Phase 4 Entecavir
29 A 12-Month Open Label Safety Study of Methylphenidate Hydrochloride Extended-Release Capsules (Aptensio XR®) in Children Ages 4-5 Years Diagnosed With Attention-Deficit/Hyperactivity Disorder (ADHD) Unknown status NCT02677519 Phase 4 Aptensio XR
30 The Effect on Overall Mortality of a National Policy of Limiting Measles Vaccination to Children Below 12 Months of Age Unknown status NCT01306006 Phase 4
31 Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma: a Randomized Clinical Trial. Unknown status NCT01494974 Phase 4
32 Multicenter Study Evaluating the Efficacy of Dicopeg Junior in Comparison With Lactulose for the Treatment of Functional Constipation in Children Aged 6 Months to 6 Years. A Prospective, Randomized Study. Unknown status NCT03177434 Phase 4 polyethylene glycols (PEG) 3350;Lactulose Oral Product
33 The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders Unknown status NCT03122158 Phase 4 Escitalopram
34 Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island Unknown status NCT02904070 Phase 4
35 Healthy Opportunities for Physical Activity and Nutrition (HOP'N) After-School Project Unknown status NCT01015599 Phase 4
36 Effect of Perineural Dexmedetomidine on the ED50 Ropivacaine for Brachial Plexus Blocks in Pediatric Patients: a Randomized Trial Unknown status NCT02781246 Phase 4 perineural dexmedetomidine
37 Effects of a Probiotic Supplement on Symptoms of ADHD and Anxiety in Children Unknown status NCT02545634 Phase 4
38 Effect of Vitamin d Supplementation on the Control of Persistent Asthma in Children at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02053402 Phase 4 Vitamin D
39 Randomized and Controlled Study of Endoscopic Ligation, Nadolol and Isosorbide Mononitrate vs Endoscopic Ligation and Nadolol Alone, or Associated With Isosorbide Mononitrate or Prazosin, Depending of the Hemodinamyc Response Unknown status NCT00563602 Phase 4
40 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
41 Phase 4 Study of Sarpogrelate That Prevent Contrast-induced Nephropathy Unknown status NCT01165567 Phase 4 sarpogrelate
42 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
43 Double-Blind Randomised Investigation of Tibolone Alone or in Adjunct to Standard Antidepressant Treatment for Depression in Menopausal Women Unknown status NCT01470092 Phase 4 Tibolone
44 Immunogenicity Of A Prophylactic Quadrivalent Human Papillomavirus (Types 6, 11, 16, And 18) L1 Virus-Like Particle Vaccine In Male And Female Adolescent Transplant Recipients. Unknown status NCT01101750 Phase 4
45 A Multicenter Study to Evaluate the Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
46 Oxytocin-based Pharmacotherapy for Autism Spectrum Disorders: Investigating the Neural and Behavioral Effects of a Promising Intervention Approach Unknown status NCT02940574 Phase 4 Syntocinon (Oxytocin)
47 Trial of Ablation of Small Hepatocellular Carcinomas in Patients of Cirrhosis Unknown status NCT01438437 Phase 4
48 Chemoembolization With or Without Antiviral Therapy for Unresectable HBV-related Hepatocellular Carcinoma With Low HBV DNA Replication: Effectiveness and Safety. A Prospective and Randomized Clinical Trial Unknown status NCT01894269 Phase 4 Lamivudine 100mg once daily; or Entecavir 0.5mg once daily.
49 A Comparison of Two Doses of Intranasal Dexmedetomidine for Premedication in Children - a Double- Blind Randomised Controlled Trial Unknown status NCT02459509 Phase 4 Dexmedetomidine
50 Effectiveness Of Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia: Randomized Placebo-Controlled Clinical Trial Unknown status NCT01361425 Phase 4 methildopa;placebo

Search NIH Clinical Center for Children's Interstitial Lung Disease

Genetic Tests for Children's Interstitial Lung Disease

Anatomical Context for Children's Interstitial Lung Disease

MalaCards organs/tissues related to Children's Interstitial Lung Disease:

Testes, Liver, Brain, Lung, Bone, Heart, Breast

Publications for Children's Interstitial Lung Disease

Articles related to Children's Interstitial Lung Disease:

(show all 30)
# Title Authors PMID Year
One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD). 61
31748256 2020
Patient education for children with interstitial lung diseases and their caregivers: A pilot study. 61
30709570 2019
Long-Term Lung Function and Exercise Capacity in Postinfectious chILD. 61
31032143 2019
ChILD - Children's interstitial lung disease. 61
30519307 2018
The European research collaboration for Children's Interstitial Lung Disease (ChILDEU) ERS Clinical Research Collaboration. 61
30523205 2018
Development and validation of a health-related quality of life questionnaire for pediatric patients with interstitial lung disease. 61
29687642 2018
Diagnostic accuracy and therapeutic relevance of thoracoscopic lung biopsies in children. 61
29578653 2018
International management platform for children's interstitial lung disease (chILD-EU). 61
29056600 2018
Increased Risk of Interstitial Lung Disease in Children with a Single R288K Variant of ABCA3. 61
26928390 2016
Update on Diffuse Lung Disease in Children. 61
26502226 2016
Transforming growth factor-beta 1 in humidifier disinfectant-associated children's interstitial lung disease. 61
26111363 2016
Humidifier disinfectant-associated children's interstitial lung disease: Computed tomographic features, histopathologic correlation and comparison between survivors and non-survivors. 61
25991482 2016
[Modern Views on Children's Interstitial Lung Disease]. 61
26234096 2015
Humidifier disinfectant-associated children's interstitial lung disease. 61
24199596 2014
[Neuroendocrine cell hyperplasia of infancy--case study]. 61
24964239 2014
Diffuse lung disease in infancy and childhood: expanding the chILD classification. 61
24117670 2013
Interstitial lung disease in children. 61
23973003 2013
Inhalation toxicity of humidifier disinfectants as a risk factor of children's interstitial lung disease in Korea: a case-control study. 61
23755124 2013
New coding in the International Classification of Diseases, Ninth Revision, for children's interstitial lung disease. 61
22948581 2012
Paediatric interstitial lung disease: classification and definitions. 61
22018036 2011
Familial neuroendocrine cell hyperplasia of infancy. 61
20623780 2010
ChILD Family Education. 61
22332033 2010
Infants and Young Children with Children's Interstitial Lung Disease. 61
22332029 2010
Round Table Discussion: Children's Interstitial Lung Disease. 61
22332034 2010
Genetic Basis of Children's Interstitial Lung Disease. 61
22087432 2010
Expanding Our Understanding of Children's Interstitial Lung Disease. 61
22332027 2010
Serum KL-6 differentiates neuroendocrine cell hyperplasia of infancy from the inborn errors of surfactant metabolism. 61
19237389 2009
Evaluating infants and children with interstitial lung disease. 61
17562503 2007
How to evaluate and treat children's interstitial lung disease. 61
16798580 2006
Surfactant dysfunction mutations in children's interstitial lung disease and beyond. 61
16216835 2005

Variations for Children's Interstitial Lung Disease

Expression for Children's Interstitial Lung Disease

Search GEO for disease gene expression data for Children's Interstitial Lung Disease.

Pathways for Children's Interstitial Lung Disease

GO Terms for Children's Interstitial Lung Disease

Sources for Children's Interstitial Lung Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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