Aliases & Classifications for Chlamydia

MalaCards integrated aliases for Chlamydia:

Name: Chlamydia 12 76 3 15
Chlamydial Infection 12 55
Chlamydia Trachomatis Infectious Disease 12
Chlamydia Infections 73
Chlamydial Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11263
ICD10 33 A56.2 A74.9
UMLS 73 C0008149

Summaries for Chlamydia

Disease Ontology : 12 A commensal bacterial infectious disease that is caused by Chlamydia trachomatis.

MalaCards based summary : Chlamydia, also known as chlamydial infection, is related to trachoma and pelvic inflammatory disease, and has symptoms including fever, pelvic pain and pruritus. An important gene associated with Chlamydia is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Women under 25 and older women with risk factors need testing every year.

Wikipedia : 76 Chlamydia infection, often simply known as chlamydia, is a sexually transmitted infection caused by the... more...

Related Diseases for Chlamydia

Diseases related to Chlamydia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 542)
# Related Disease Score Top Affiliating Genes
1 trachoma 33.3 HSPD1 IDO1 IL10 TNF
2 pelvic inflammatory disease 31.8 CD40LG CRP HSPD1 TLR2 TLR4
3 conjunctivitis 31.5 CXCL8 IFNG IL6
4 reactive arthritis 31.3 CD79A CRP HSPD1 IFNG IL10 IL6
5 vaginitis 31.2 CXCL8 IL1B IL6
6 endometritis 31.2 IL1B IL6 TNF
7 urethritis 31.0 CD40LG CD79A HSPD1
8 arthritis 30.8 CXCL8 IFNG IL10 IL1B IL6 TNF
9 salpingitis 30.8 CD40LG CD79A HSPD1
10 pharyngitis 30.8 CRP CXCL8 IL1B
11 arteries, anomalies of 30.8 CRP IL1B IL6 TNF
12 ischemic heart disease 30.7 CRP IL6 TNF
13 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.7 HSPD1 IFNG IL10
14 mycobacterium chelonae 30.6 CXCL8 TLR2
15 prostatitis 30.6 CXCL8 IL10 IL1B IL6 TNF
16 vulvovaginitis 30.6 CXCL8 HSPD1 IL10
17 spondyloarthropathy 30.5 IFNG IL10 IL6 TNF
18 acute transverse myelitis 30.5 CXCL8 IL10 IL6
19 poliomyelitis 30.5 IFNG IL10 TNF
20 chronic follicular conjunctivitis 30.4 CD79A IL1B
21 arteriosclerosis 30.4 CRP HSPD1 IL10 IL6
22 avian influenza 30.4 CXCL8 IL6 TNF
23 rosacea 30.4 IL6 TLR2 TNF
24 campylobacteriosis 30.3 IFNG IL1B TLR4
25 keratoconjunctivitis 30.3 CD79A CXCL8 IFNG TNF
26 aortic aneurysm, familial abdominal, 1 30.3 CRP IL1B IL6
27 neuritis 30.3 IFNG IL1B TNF
28 chronic salpingitis 30.2 CD79A MCL1 TNF
29 erythema multiforme 30.2 CD79A IFNG TNF
30 transverse myelitis 30.2 CXCL8 IL10 IL6 TNF
31 adult respiratory distress syndrome 30.2 CXCL8 IL10 IL6 TNF
32 relapsing-remitting multiple sclerosis 30.1 IFNG IL10 TNF
33 hemophagocytic lymphohistiocytosis 30.1 CXCL8 IFNG IL10 TNF
34 cytomegalovirus infection 30.1 CXCL8 IFNG IL10 IL6 TNF
35 coronary stenosis 30.1 CRP IL6 TLR4
36 rubella 30.1 CD40LG IL10 TNF
37 listeriosis 30.0 IDO1 IL10 IL6 TNF
38 cat-scratch disease 30.0 CD40LG HSPD1 IFNG
39 acute salpingitis 30.0 CD40LG CD79A MCL1 TNF
40 temporal arteritis 30.0 CD40LG CRP IFNG IL6
41 bacterial vaginosis 30.0 CXCL8 IL1B IL6 TLR2 TLR4 TNF
42 bronchiolitis obliterans 29.9 CXCL8 IFNG IL10 IL6 TNF
43 mumps 29.8 CD40LG IFNG TNF
44 vascular disease 29.7 CRP HSPD1 IL6 NOS2 TNF
45 kawasaki disease 29.7 CRP HSPD1 IL10 IL6 TNF
46 tonsillitis 29.6 CD79A CXCL8 IFNG IL1B IL6 TNF
47 gingivitis 29.6 CD79A CXCL8 IL1B IL6 TNF
48 keratoconjunctivitis sicca 29.5 CD79A IL10 IL1B IL6 TNF
49 pneumonia 29.4 CD40LG CRP CXCL8 IL10 IL1B IL6
50 lymphadenitis 29.4 CXCL8 IFNG IL10 IL1B TLR4 TNF

Graphical network of the top 20 diseases related to Chlamydia:



Diseases related to Chlamydia

Symptoms & Phenotypes for Chlamydia

UMLS symptoms related to Chlamydia:


fever, pelvic pain, pruritus

GenomeRNAi Phenotypes related to Chlamydia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 IL10 IL1B MCL1 CASP1 NOS2 CD40LG
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 CXCL8 IL10 IL1B MCL1 CASP1 NOS2
3 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 9.35 MAPK14 MCL1 NOS2 RAC1 RAF1

MGI Mouse Phenotypes related to Chlamydia:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.48 CASP1 CD40LG CD79A HSPD1 IDO1 IFNG
2 cardiovascular system MP:0005385 10.46 TLR4 TNF CASP1 CD40LG CRP IDO1
3 hematopoietic system MP:0005397 10.43 MAPK14 MCL1 NOS2 RAC1 RAF1 TLR2
4 immune system MP:0005387 10.42 TNF CASP1 CD40LG CD79A CRP IDO1
5 homeostasis/metabolism MP:0005376 10.41 CASP1 CD40LG CD79A CRP IDO1 IFNG
6 endocrine/exocrine gland MP:0005379 10.33 CASP1 CD40LG IFNG IL10 IL6 MAPK14
7 integument MP:0010771 10.32 CASP1 CD40LG IFNG IL10 IL1B IL6
8 growth/size/body region MP:0005378 10.31 HSPD1 IFNG IL10 IL1B IL6 MAPK14
9 mortality/aging MP:0010768 10.31 RAF1 TLR2 TLR4 TNF CASP1 CD40LG
10 nervous system MP:0003631 10.2 MAPK14 NOS2 RAC1 RAF1 TLR2 TLR4
11 muscle MP:0005369 10.18 MAPK14 NOS2 RAC1 RAF1 TLR2 TLR4
12 digestive/alimentary MP:0005381 10.16 CASP1 IFNG IL10 IL6 NOS2 TLR2
13 liver/biliary system MP:0005370 10.16 NOS2 RAF1 TLR2 TLR4 TNF CD79A
14 neoplasm MP:0002006 10.15 CASP1 CD79A IFNG IL10 IL1B IL6
15 craniofacial MP:0005382 10.11 RAC1 RAF1 TNF IFNG IL10 IL1B
16 reproductive system MP:0005389 9.97 CASP1 CD40LG HSPD1 IDO1 IFNG IL10
17 renal/urinary system MP:0005367 9.91 CASP1 CD40LG CD79A IDO1 IFNG IL6
18 respiratory system MP:0005388 9.61 RAF1 TLR2 TLR4 TNF IFNG IL10
19 skeleton MP:0005390 9.36 CD40LG IFNG IL10 IL1B IL6 MAPK14

Drugs & Therapeutics for Chlamydia

Drugs for Chlamydia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 195)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 83905-01-5 55185 447043
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 60-54-8 5353990
5
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 143491-57-0 60877
6
Cefixime Approved, Investigational Phase 4,Phase 3,Not Applicable 79350-37-1 54362 5362065
7
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
8
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
9
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
10
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 114-07-8 12560
11
Albendazole Approved, Vet_approved Phase 4,Not Applicable 54965-21-8 2082
12
Ivermectin Approved, Investigational, Vet_approved Phase 4,Not Applicable 70288-86-7 6474909
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
14 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
15 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
16 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
17 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
19 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Phase 2,Not Applicable
23 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
24 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
25
Tenofovir Phase 4,Phase 3,Phase 2,Not Applicable 147127-20-6 464205
26 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
27 Contraceptive Agents Phase 4,Phase 3,Not Applicable
28 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
29 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
30 Erythromycin Estolate Phase 4,Phase 3,Phase 2
31 Erythromycin Ethylsuccinate Phase 4,Phase 3,Phase 2
32 Erythromycin stearate Phase 4,Phase 3,Phase 2
33 N-Methylaspartate Phase 4,Phase 3
34 Anthelmintics Phase 4,Phase 3,Not Applicable
35 Antimitotic Agents Phase 4,Not Applicable
36 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Carboxymethylcellulose Sodium Phase 4,Phase 2
38 Cathartics Phase 4,Phase 2
39 Laxatives Phase 4,Phase 2
40 alanine Nutraceutical Phase 4,Phase 3
41 Aspartic Acid Nutraceutical Phase 4,Phase 3
42
Ganciclovir Approved, Investigational Phase 3 82410-32-0 3454
43
Ethanol Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 64-17-5 702
44
Rifampicin Approved Phase 3,Phase 2 13292-46-1 5458213 5381226
45
Ceftriaxone Approved Phase 3,Phase 2,Not Applicable 73384-59-5 5479530 5361919
46
Metronidazole Approved Phase 3 443-48-1 4173
47 silver nitrate Approved, Investigational Phase 3
48
Estradiol Approved, Investigational, Vet_approved Phase 3,Not Applicable 50-28-2 5757
49 Estradiol valerate Approved, Investigational, Vet_approved Phase 3,Not Applicable 979-32-8
50
Ethinyl Estradiol Approved Phase 3,Not Applicable 57-63-6 5991

Interventional clinical trials:

(show top 50) (show all 295)
# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya Unknown status NCT01015989 Phase 4
3 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4 emtricitabine/tenofovir disoproxil fumarate
4 Washington State Community Expedited Partner Treatment (EPT) Trial Completed NCT01665690 Phase 4
5 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4 Azithromcyin;Azithromycin
6 Trachoma Amelioration in Northern Amhara (TANA) Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
7 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
8 Trachoma Elimination Follow-up Completed NCT00221364 Phase 4 Mass treatment with oral azithromycin to an entire village
9 Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania Completed NCT00347763 Phase 4
10 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
11 Microorganism in Overactive Bladder Patients Completed NCT00883818 Phase 4 azithromycin, doxycycline
12 Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
13 Doxycycline Prophylaxis at Vacuum Aspiration Trial Completed NCT00547170 Phase 4 Doxycycline pre-operatively;Doxycycline post-operatively
14 A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery Completed NCT00522860 Phase 4
15 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
16 Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania Completed NCT00347607 Phase 4
17 Mortality Reduction After Oral Azithromycin: Morbidity Study Completed NCT02048007 Phase 4 Azithromycin;Placebo
18 Stage Matched Intervention to Increase Dual Method Use Completed NCT00436306 Phase 4
19 Effectiveness of Integrating Prenatal Care in Reducing HIV/STDs Among Young Pregnant Women Completed NCT00628771 Phase 4
20 AZithromycin Against pLacebo in Exacerbations of Asthma Completed NCT01444469 Phase 4 Zithromax;Placebo
21 HPTN 073 Black Men Who Have Sex With Men (MSM) Pre-Exposure Prophylaxis (PrEP) Completed NCT01808352 Phase 4 FTC/TDF
22 PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5 Completed NCT02149888 Phase 4 Tenofovir/emtricitabine
23 Partnership for Rapid Elimination of Trachoma Completed NCT00792922 Phase 4 Azithromycin;Azithromycin
24 Sanitation, Water, and Instruction in Face-washing for Trachoma Recruiting NCT02754583 Phase 4 Azithromycin;Tetracycline;Albendazole
25 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Recruiting NCT03233880 Phase 4 Azithromycin 1gm
26 Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection Not yet recruiting NCT03532464 Phase 4 azithromycin;doxycycline
27 Trachoma Elimination Study by Focused Antibiotic (TESFA) Not yet recruiting NCT03523156 Phase 4 Azithromycin mass treatment;Azithromycin targeted treatment
28 Kebele Elimination of Trachoma for Ocular Health Not yet recruiting NCT03335072 Phase 4 Azithromycin
29 Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin Not yet recruiting NCT03570814 Phase 4 Administration of Albendazole on Day 1;Administration of Ivermectin on Day 1;Administration of Azithromycin on Day 1;Administration of Azithromycin on Day 15
30 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
31 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4 Azithromycin
32 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
33 PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients Unknown status NCT00251849 Phase 3 Rifalazil
34 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
35 Identigene STD Test Collection Kit Validation Study Unknown status NCT01471392 Phase 3
36 Evaluate the Use of Ganciclovir Gel 0.3% for the Treatment of Conjunctivitis Caused by Adenovirus Unknown status NCT01600365 Phase 3 Ophthalmic gel (placebo);Ganciclovir
37 Partner Notification for Chlamydia in Primary Care Completed NCT00112255 Phase 3
38 Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin Completed NCT01113931 Phase 3 Doxycyline Hyclate tablet;Vibramycin (doxycyline hyclate) capsule
39 Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities Completed NCT00980148 Phase 3 Azithromycin;Doxycycline
40 Home Screening for Chlamydia Surveillance Completed NCT00177437 Phase 3
41 Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
42 Efficacy and Safety Study of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea Completed NCT02210325 Phase 3 solithromycin;ceftriaxone;azithromycin
43 Bacterial Vaginosis Home Screening to Prevent STDs Completed NCT00667368 Phase 3 Metronidazole
44 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
45 The CLARICOR Trial: Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease Completed NCT00121550 Phase 3 clarithromycin
46 ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study Completed NCT00245908 Phase 3 azithromycin
47 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
48 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3 PRO 2000/5;Placebo
49 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
50 HIV Prevention for African American Teens Completed NCT00279799 Phase 3

Search NIH Clinical Center for Chlamydia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Chlamydia

Anatomical Context for Chlamydia

MalaCards organs/tissues related to Chlamydia:

41
Testes, Eye, Endothelial, T Cells, Heart, Prostate, Monocytes

Publications for Chlamydia

Articles related to Chlamydia:

(show top 50) (show all 1591)
# Title Authors Year
1
Chlamydia pneumoniae infection promotes monocyte transendothelial migration by increasing vascular endothelial cell permeability via the tyrosine phosphorylation of VE-cadherin. ( 29462613 )
2018
2
Impact of screening on chlamydia infections. ( 29970588 )
2018
3
Impact of the Levonorgestrel-Releasing Intrauterine System on the Progression of Chlamydia trachomatis Infection to Pelvic Inflammatory Disease in a Baboon Model. ( 29253201 )
2018
4
Interferon-I^ interferes with host cell metabolism during intracellular Chlamydia trachomatis infection. ( 29885991 )
2018
5
Screening for Chlamydia trachomatis and Neisseria gonorrhoeae Infections in Men Who Have Sex With Men: Diagnostic Accuracy of Nucleic Acid Amplification Test on Pooled Urine, Anorectal, and Pharyngeal Specimens. ( 29419710 )
2018
6
The Chlamydia trachomatis PmpD adhesin forms higher order structures through disulphide-mediated covalent interactions. ( 29912892 )
2018
7
Diagnostic accuracy of a prototype rapid chlamydia and gonorrhoea recombinase polymerase amplification assay: a multi-centre cross-sectional pre-clinical evaluation. ( 29906594 )
2018
8
Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein (MOMP)-based Fusion Antigen CTH522 into Protein Nanoparticles. ( 29452143 )
2018
9
HPV and Chlamydia trachomatis coinfection in women with Pap smear abnormality: baseline data of the HPV Pathogen ISS study. ( 29932086 )
2018
10
Clinical signs of trachoma are prevalent among Solomon Islanders who have no persistent markers of prior infection with <i>Chlamydia trachomatis</i>. ( 29588922 )
2018
11
Chlamydia trachomatis paralyses neutrophils to evade the host innate immune response. ( 29946164 )
2018
12
Genital<i>Chlamydia trachomatis</i>infections in young adults - a school-based bio-behavioural study in urban areas, Poland, 2012 to 2015. ( 29439753 )
2018
13
Association of asymptomatic Chlamydia trachomatis infection with male infertility and the effect of antibiotic therapy in improvement of semen quality in infected infertile men. ( 29292525 )
2018
14
Observational study of anorectal Chlamydia trachomatis infections in France through the lymphogranuloma venereum surveillance network, 2010-2015. ( 29973128 )
2018
15
Preliminary evidence of the seroprevalence and risk factors associated with Chlamydia abortus infection in goats on the Canary Islands, Spain. ( 29980954 )
2018
16
Molecular mechanisms of Chlamydia trachomatis resistance to antimicrobial drugs. ( 28930567 )
2018
17
Detection of urinary Chlamydia trachomatis, Mycoplasma genitalium and human papilloma virus in the first trimester of pregnancy by PCR method. ( 29866110 )
2018
18
Effect of rectal douching/enema on rectal gonorrhoea and chlamydia among a cohort of men who have sex with men on HIV pre-exposure prophylaxis. ( 29907624 )
2018
19
Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein. ( 29964134 )
2018
20
Detection of<i>Chlamydia trachomatis</i>in rectal specimens in women and its association with anal intercourse: a systematic review and meta-analysis. ( 29431148 )
2018
21
Conjunctival transcriptome profiling of Solomon Islanders with active trachoma in the absence of Chlamydia trachomatis infection. ( 29467021 )
2018
22
Rising Chlamydia and Gonorrhoea Incidence and Associated Risk Factors Among Female Sex Workers in Australia: A Retrospective Cohort Study. ( 29420449 )
2018
23
Association of Chlamydia trachomatis infections with preterm delivery; a systematic review and meta-analysis. ( 29914397 )
2018
24
Repeat Chlamydia Diagnoses Increase the Hazard of Pelvic Inflammatory Disease among U.S. Army females: A Retrospective Cohort Analysis. ( 29870505 )
2018
25
Detection of Chlamydiaceae and Chlamydia-like organisms on the ocular surface of children and adults from a trachoma-endemic region. ( 29743637 )
2018
26
Plasmid Negative Regulation of CPAF Expression Is Pgp4 Independent and Restricted to Invasive<i>Chlamydia trachomatis</i>Biovars. ( 29382731 )
2018
27
Prevalence of<i>Chlamydia trachomatis</i>-Specific Antibodies before and after Mass Drug Administration for Trachoma in Community-Wide Surveys of Four Communities in Nepal. ( 29141720 )
2018
28
Barriers and Facilitators of Partner Treatment of Chlamydia: A Qualitative Investigation with Prescribers and Community Pharmacists. ( 29419807 )
2018
29
Chlamydia trachomatis genotypes A and B from urogenital specimens of patients in Spain: an organotropism-related gene and multilocus sequence typing study. ( 29427803 )
2018
30
Evaluation of the reproducibility of a serological test for antibodies to Chlamydia trachomatis pgp3: A potential surveillance tool for trachoma programs. ( 29501689 )
2018
31
Pathology after<i>Chlamydia trachomatis</i>infection is driven by nonprotective immune cells that are distinct from protective populations. ( 29440378 )
2018
32
Chlamydia trachomatis inhibits the production of pro-inflammatory cytokines in human PBMCs through induction of IL-10. ( 29388547 )
2018
33
Pelvic inflammatory disease risk following negative results from chlamydia nucleic acid amplification tests (NAATs) versus non-NAATs in Denmark: A retrospective cohort. ( 29293503 )
2018
34
Stimulated peripheral blood mononuclear cells from chlamydia-infected women release predominantly Th1-polarizing cytokines. ( 29914793 )
2018
35
Population-based analysis of ocular Chlamydia trachomatis in trachoma-endemic West African communities identifies genomic markers of disease severity. ( 29482619 )
2018
36
Association between Prior <i>Chlamydia trachomatis</i> Infection and Ectopic Pregnancy at a Tertiary Care Hospital in South Western Uganda. ( 29686708 )
2018
37
Transformation of Chlamydia: Current approaches and impact on our understanding of chlamydial infection biology. ( 29409975 )
2018
38
Overfilled urine specimens for gonorrhea and chlamydia testing: Implications for practice. ( 29422146 )
2018
39
Only recent sexual partners contribute to oropharyngeal gonorrhoea positivity: the number of sexual partners over different time periods as an indicator of gonorrhoea and chlamydia infection duration among men who have sex with men. ( 29973330 )
2018
40
Risk of Pelvic Inflammatory Disease in Relation to Chlamydia and Gonorrhea Testing, Repeat Testing, and Positivity: A Population-Based Cohort Study. ( 29136127 )
2018
41
Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease. ( 29426279 )
2018
42
Fitz-Hugh-Curtis syndrome in a man positive for Chlamydia trachomatis. ( 29417387 )
2018
43
Racial/ethnic disparities in the lifetime risk of Chlamydia trachomatis diagnosis and adverse reproductive health outcomes among women in King County, Washington. ( 29420716 )
2018
44
National prevalence estimates of chlamydia and gonorrhoea in the Netherlands. ( 29925670 )
2018
45
Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1I^ Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. ( 29937375 )
2018
46
Vaccination of koalas (Phascolarctos cinereus) against Chlamydia pecorum using synthetic peptides derived from the major outer membrane protein. ( 29953523 )
2018
47
An Online Risk Index for the Cross-Sectional Prediction of New HIV Chlamydia, and Gonorrhea Diagnoses Across U.S. Counties and Across Years. ( 29427233 )
2018
48
Prevalence of Chlamydia trachomatis in Pregnant Iranian Women: A Systematic Review and Meta-Analysis. ( 29935063 )
2018
49
Chlamydia trachomatis and Adverse Pregnancy Outcomes: Meta-analysis of Patients With and Without Infection. ( 29417367 )
2018
50
Chlamydia trachomatis in Cervical Lymph Node of Man with Lymphogranuloma Venereum, Croatia, 2014<sup>1</sup>. ( 29553338 )
2018

Variations for Chlamydia

Expression for Chlamydia

Search GEO for disease gene expression data for Chlamydia.

Pathways for Chlamydia

Pathways related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 CASP1 CD40LG CD79A CRP CXCL8 IFNG
2
Show member pathways
13.96 CD40LG CXCL8 IL10 IL1B IL6 MAPK14
3
Show member pathways
13.84 CASP1 CD40LG CXCL8 IFNG IL10 IL1B
4
Show member pathways
13.63 CXCL8 IFNG IL10 IL1B IL6 MAPK14
5
Show member pathways
13.58 CD40LG CXCL8 IL10 IL1B IL6 MAPK14
6
Show member pathways
13.53 CASP1 CD40LG CXCL8 IFNG IL10 IL1B
7
Show member pathways
13.42 CASP1 CD40LG CXCL8 IL10 IL1B IL6
8
Show member pathways
13.11 IL6 MCL1 RAC1 RAF1 TLR2 TLR4
9
Show member pathways
13.06 CASP1 CD40LG CD79A MAPK14 RAC1 RAF1
10
Show member pathways
13.06 CASP1 CXCL8 IFNG IL10 IL1B IL6
11
Show member pathways
13.04 MAPK14 NOS2 RAB14 RAC1 RAF1 TNF
12
Show member pathways
13.04 CD40LG CXCL8 HSPD1 IFNG IL10 IL1B
13
Show member pathways
13.01 CASP1 IL6 MAPK14 RAC1 RAF1 TNF
14
Show member pathways
12.99 CD79A IFNG IL1B MAPK14 RAC1 RAF1
15 12.96 CXCL8 IFNG IL6 NOS2 RAC1 RAF1
16
Show member pathways
12.96 CASP1 CXCL8 IFNG IL1B IL6 MAPK14
17
Show member pathways
12.96 CASP1 CXCL8 IFNG IL1B IL6 MAPK14
18 12.9 CASP1 IL1B MAPK14 RAC1 RAF1 TNF
19
Show member pathways
12.84 CD40LG IL1B IL6 TLR2 TLR4 TNF
20
Show member pathways
12.82 CXCL8 IFNG IL10 IL1B IL6 MCL1
21
Show member pathways
12.81 CD40LG IFNG IL1B MAPK14 RAF1 TNF
22
Show member pathways
12.79 IFNG IL10 IL1B IL6 MAPK14 NOS2
23
Show member pathways
12.77 CXCL8 IL6 MAPK14 RAC1 RAF1 TLR2
24 12.75 CD40LG CD79A IDO1 IFNG IL10 IL1B
25
Show member pathways
12.7 CD79A MAPK14 RAC1 RAF1 TNF
26
Show member pathways
12.7 CASP1 CD40LG IL1B MAPK14 TLR2 TLR4
27
Show member pathways
12.63 IFNG IL10 IL1B IL6 MAPK14 TLR2
28
Show member pathways
12.61 IL1B MAPK14 NOS2 RAC1 RAF1
29
Show member pathways
12.61 CD40LG IFNG IL10 IL1B IL6 MAPK14
30
Show member pathways
12.54 MAPK14 RAC1 RAF1 TLR2 TLR4
31
Show member pathways
12.54 CXCL8 IFNG IL1B IL6 MAPK14 TLR2
32 12.49 MAPK14 RAC1 RAF1 TLR2 TLR4 TNF
33
Show member pathways
12.48 CXCL8 MAPK14 NOS2 RAC1 RAF1
34
Show member pathways
12.47 CRP IFNG IL1B IL6 TNF
35
Show member pathways
12.46 CD79A MAPK14 RAC1 RAF1
36
Show member pathways
12.46 IFNG IL10 IL1B IL6 TLR2 TLR4
37
Show member pathways
12.45 CXCL8 IFNG IL1B IL6 MAPK14 NOS2
38
Show member pathways
12.41 CXCL8 IL6 TLR2 TLR4 TNF
39
Show member pathways
12.41 CASP1 IL10 IL1B IL6 MAPK14 RAF1
40
Show member pathways
12.41 CXCL8 IL1B IL6 MAPK14 NOS2 RAF1
41
Show member pathways
12.4 IFNG IL6 MAPK14 RAC1
42 12.39 IFNG IL6 NOS2 TLR2 TLR4 TNF
43 12.39 CXCL8 HSPD1 IL10 IL1B IL6 TNF
44
Show member pathways
12.36 CASP1 IFNG IL1B TLR4 TNF
45 12.35 CASP1 CD40LG MCL1 TNF
46
Show member pathways
12.34 CXCL8 IFNG IL1B IL6 NOS2 TLR2
47
Show member pathways
12.33 CD40LG IFNG IL10 IL1B MAPK14 NOS2
48 12.31 HSPD1 IFNG IL10 IL1B IL6 MAPK14
49 12.28 CXCL8 IL6 MAPK14 RAF1
50
Show member pathways
12.28 MAPK14 RAC1 RAF1 TNF

GO Terms for Chlamydia

Cellular components related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 CASP1 CD40LG CRP CXCL8 IFNG IL10
2 extracellular space GO:0005615 9.61 CD40LG CRP CXCL8 HSPD1 IFNG IL10
3 intracellular GO:0005622 9.32 CD40LG CXCL8 IFNG MAPK14 NOS2 RAB14
4 lipopolysaccharide receptor complex GO:0046696 9.26 HSPD1 TLR4

Biological processes related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 activation of MAPK activity GO:0000187 9.98 IL1B MAPK14 TLR4 TNF
2 platelet activation GO:0030168 9.98 CD40LG IL6 RAC1 RAF1
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.98 IL10 IL1B IL6 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.96 CRP IL6 TLR2 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 CD40LG IL1B IL6 TLR2 TLR4 TNF
6 cellular response to mechanical stimulus GO:0071260 9.94 CASP1 IL1B RAC1 TLR4
7 regulation of insulin secretion GO:0050796 9.92 IFNG IL1B NOS2 TNF
8 B cell differentiation GO:0030183 9.91 CD40LG CD79A IL10
9 positive regulation of JNK cascade GO:0046330 9.91 IL1B TLR4 TNF
10 response to glucocorticoid GO:0051384 9.91 IL10 IL6 TNF
11 positive regulation of T cell proliferation GO:0042102 9.9 CD40LG IL1B IL6
12 humoral immune response GO:0006959 9.9 IFNG IL6 TNF
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 IL1B TLR2 TLR4 TNF
14 cellular response to organic substance GO:0071310 9.88 CASP1 IL1B MAPK14
15 positive regulation of interferon-gamma production GO:0032729 9.88 HSPD1 IL1B TLR4 TNF
16 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.87 IL1B MCL1 TNF
17 response to bacterium GO:0009617 9.87 CASP1 NOS2 TLR4
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.86 HSPD1 TLR2 TLR4
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 IFNG IL1B TLR4 TNF
20 cellular response to lipopolysaccharide GO:0071222 9.86 CASP1 CXCL8 IL10 IL6 MAPK14 NOS2
21 positive regulation of cytokine secretion GO:0050715 9.85 CASP1 IL10 TNF
22 negative regulation of interleukin-6 production GO:0032715 9.85 IL10 TLR4 TNF
23 B cell proliferation GO:0042100 9.85 CD40LG CD79A HSPD1 IL10
24 positive regulation of interleukin-8 production GO:0032757 9.84 IL1B TLR2 TLR4 TNF
25 positive regulation of interleukin-10 production GO:0032733 9.83 CD40LG HSPD1 TLR2 TLR4
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.81 IFNG IL1B TNF
27 positive regulation of macrophage activation GO:0043032 9.8 HSPD1 IL10 TLR4
28 positive regulation of chemokine production GO:0032722 9.8 IL6 TLR2 TLR4 TNF
29 positive regulation of interleukin-6 production GO:0032755 9.8 HSPD1 IL1B IL6 TLR2 TLR4 TNF
30 response to molecule of bacterial origin GO:0002237 9.79 CXCL8 IL10 TLR2
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.78 IL10 IL1B TNF
32 cellular response to lipoteichoic acid GO:0071223 9.77 MAPK14 TLR2 TLR4
33 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL1B MAPK14 TLR2 TLR4 TNF
34 negative regulation of lipid storage GO:0010888 9.76 CRP IL6 TNF
35 regulation of cytokine secretion GO:0050707 9.74 TLR2 TLR4
36 negative regulation of interleukin-17 production GO:0032700 9.74 IFNG TLR4
37 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF
38 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR4 TNF
39 death-inducing signaling complex assembly GO:0071550 9.73 RAF1 TNF
40 endothelial cell apoptotic process GO:0072577 9.73 IL10 TNF
41 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 IL10 TLR4
42 regulation of establishment of endothelial barrier GO:1903140 9.72 IL1B TNF
43 negative regulation of cytokine secretion involved in immune response GO:0002740 9.72 IL10 TNF
44 positive regulation of fever generation GO:0031622 9.71 IL1B TNF
45 regulation of cytokine production involved in inflammatory response GO:1900015 9.71 MAPK14 NOS2
46 regulation of immunoglobulin secretion GO:0051023 9.71 CD40LG TNF
47 interleukin-1 beta production GO:0032611 9.7 CASP1 IL1B
48 positive regulation of killing of cells of other organism GO:0051712 9.7 IFNG NOS2
49 sequestering of triglyceride GO:0030730 9.7 IL1B TNF
50 receptor biosynthetic process GO:0032800 9.69 IL10 TNF

Molecular functions related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 CASP1 CD40LG CD79A CRP CXCL8 HSPD1
2 lipopolysaccharide binding GO:0001530 9.33 HSPD1 TLR2 TLR4
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
4 cytokine activity GO:0005125 9.17 CD40LG CXCL8 IFNG IL10 IL1B IL6

Sources for Chlamydia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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