Aliases & Classifications for Chlamydia

MalaCards integrated aliases for Chlamydia:

Name: Chlamydia 12 76 3 15
Chlamydial Infection 12 55 15
Chlamydia Trachomatis Infectious Disease 12
Chlamydia Infections 73
Chlamydial Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11263
ICD10 33 A56.2 A74.9
UMLS 73 C0008149

Summaries for Chlamydia

Disease Ontology : 12 A commensal bacterial infectious disease that is caused by Chlamydia trachomatis.

MalaCards based summary : Chlamydia, also known as chlamydial infection, is related to trachoma and pelvic inflammatory disease, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Chlamydia is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Doxycycline and Lymecycline have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Women under 25 and older women with risk factors need testing every year.

Wikipedia : 76 Chlamydia infection, often simply known as chlamydia, is a sexually transmitted infection caused by the... more...

Related Diseases for Chlamydia

Diseases related to Chlamydia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 588)
# Related Disease Score Top Affiliating Genes
1 trachoma 33.0 HSPD1 IDO1 IL10 TNF
2 pelvic inflammatory disease 32.4 CRP HSPD1 TLR2 TLR4
3 reactive arthritis 32.3 CRP HSPD1 IFNG IL10 TNF
4 salpingitis 31.0 CRP HSPD1 TNF
5 arthritis 31.0 CXCL8 IFNG IL10 IL1B IL6 TNF
6 arteries, anomalies of 30.9 CRP IL1B IL6 TNF
7 endometritis 30.7 IL1B IL6 TNF
8 conjunctivitis 30.7 CXCL8 IFNG IL4 IL6
9 pneumonia 30.6 CRP CXCL8 IL10 IL1B IL6 TLR2
10 heart disease 30.5 CRP CXCL8 IL10 IL1B IL6 TNF
11 prostatitis 30.4 CXCL8 IL10 IL1B IL6 TNF
12 ischemic heart disease 30.4 CRP IL6 TNF
13 bacterial vaginosis 30.3 CXCL8 IL1B IL6 TLR2 TLR4 TNF
14 temporal arteritis 30.3 CRP IFNG IL6 TNF
15 myocarditis 30.2 IL6 NOS2 TNF
16 pharyngitis 30.1 CRP CXCL8 IL1B
17 vascular disease 30.1 CRP HSPD1 IL6 NOS2 TNF
18 cytomegalovirus infection 30.1 CXCL8 IL1B IL6 TNF
19 bacteriuria 30.1 CXCL8 IL6 TLR4
20 asthma 30.0 CXCL8 IFNG IL10 IL1B IL4 IL6
21 cerebrovascular disease 30.0 CRP IL6 TLR4 TNF
22 spondyloarthropathy 1 30.0 CRP TLR4 TNF
23 spondylitis 30.0 CRP IL6 TNF
24 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.0 HSPD1 IFNG IL10
25 arteriosclerosis 30.0 CRP HSPD1 IL10 IL6 TLR4
26 avian influenza 30.0 CXCL8 IL6 TNF
27 keratoconjunctivitis 30.0 CXCL8 IFNG IL4 TNF
28 diabetes mellitus 29.9 CRP HSPD1 IFNG IL1B IL6 TNF
29 aortic aneurysm, familial abdominal, 1 29.9 CRP IL1B IL6
30 hemophagocytic lymphohistiocytosis 29.9 CXCL8 IFNG IL10 TNF
31 anterior uveitis 29.9 IL6 TLR2 TLR4 TNF
32 cystitis 29.9 CRP CXCL8 IL6 TLR4 TNF
33 uveitis 29.9 IFNG IL10 IL4 TNF
34 myocardial infarction 29.9 CASP1 CRP IL10 IL1B IL6 TLR4
35 multiple sclerosis 29.9 IFNG IL10 IL1B IL4 IL6 NOS2
36 preterm premature rupture of the membranes 29.8 CRP CXCL8 IL1B IL6
37 atherosclerosis susceptibility 29.8 CRP IL6 TLR4 TNF
38 mycobacterium chelonae 29.8 CXCL8 TLR2
39 pre-eclampsia 29.8 IL10 IL6 NOS2 TLR4 TNF
40 vulvovaginitis 29.8 CXCL8 HSPD1 IL10
41 sudden infant death syndrome 29.8 IL10 IL1B IL6 TNF
42 acute transverse myelitis 29.8 CXCL8 IL10 IL6
43 vaginitis 29.8 CXCL8 IL1B IL6
44 pertussis 29.8 IL10 IL1B IL6 TLR4 TNF
45 echinococcosis 29.7 IFNG IL10 IL6 TLR2 TLR4 TNF
46 genital herpes 29.7 IL10 IL4 TLR2
47 campylobacteriosis 29.7 IFNG IL1B TLR4
48 rosacea 29.7 IL6 TLR2 TNF
49 listeriosis 29.7 IDO1 IL6 TNF
50 acute cystitis 29.7 CRP CXCL8 IL6

Graphical network of the top 20 diseases related to Chlamydia:



Diseases related to Chlamydia

Symptoms & Phenotypes for Chlamydia

UMLS symptoms related to Chlamydia:


fever, pruritus, pelvic pain

GenomeRNAi Phenotypes related to Chlamydia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 CASP1 CXCL8 IL10 IL1B MCL1 NOS2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 CASP1 CXCL8 IL10 IL1B MCL1 NOS2
3 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 9.35 MAPK14 MCL1 NOS2 RAC1 RAF1

MGI Mouse Phenotypes related to Chlamydia:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.49 CASP1 CD79A HSPD1 IDO1 IFNG IL10
2 homeostasis/metabolism MP:0005376 10.47 CASP1 CD79A CRP IDO1 IFNG IL10
3 hematopoietic system MP:0005397 10.45 CASP1 CD79A IDO1 IFNG IL10 IL1B
4 immune system MP:0005387 10.45 CASP1 CD79A CRP IDO1 IFNG IL10
5 cardiovascular system MP:0005385 10.44 CASP1 CRP IDO1 IFNG IL10 IL1B
6 growth/size/body region MP:0005378 10.4 HSPD1 IFNG IL10 IL1B IL4 IL6
7 integument MP:0010771 10.39 CASP1 IFNG IL10 IL1B IL4 IL6
8 mortality/aging MP:0010768 10.38 CASP1 HSPD1 IFNG IL10 IL1B IL4
9 behavior/neurological MP:0005386 10.35 HSPD1 IFNG IL10 IL6 MAPK14 NECTIN1
10 endocrine/exocrine gland MP:0005379 10.35 CASP1 IFNG IL10 IL4 IL6 MAPK14
11 nervous system MP:0003631 10.28 CASP1 CD79A HSPD1 IFNG IL10 IL1B
12 craniofacial MP:0005382 10.24 IFNG IL10 IL1B IL4 NECTIN1 NOS2
13 liver/biliary system MP:0005370 10.24 CD79A IFNG IL10 IL4 IL6 MAPK14
14 digestive/alimentary MP:0005381 10.23 CASP1 IFNG IL10 IL4 IL6 NOS2
15 muscle MP:0005369 10.23 HSPD1 IDO1 IFNG IL10 IL6 MAPK14
16 neoplasm MP:0002006 10.21 CASP1 CD79A IFNG IL10 IL1B IL6
17 reproductive system MP:0005389 10.07 CASP1 HSPD1 IDO1 IFNG IL10 IL4
18 normal MP:0002873 10.02 CD79A IFNG IL10 IL4 MAPK14 MCL1
19 renal/urinary system MP:0005367 9.97 CASP1 CD79A IDO1 IFNG IL4 IL6
20 respiratory system MP:0005388 9.85 IFNG IL10 IL4 IL6 MAPK14 NOS2
21 skeleton MP:0005390 9.73 IFNG IL10 IL1B IL4 IL6 MAPK14
22 vision/eye MP:0005391 9.28 IFNG IL10 IL4 IL6 NECTIN1 NOS2

Drugs & Therapeutics for Chlamydia

Drugs for Chlamydia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 200)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 564-25-0 54671203
2
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
3
Tetracycline Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 60-54-8 5353990
4
Azithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 83905-01-5 55185 447043
5
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 143491-57-0 60877
6
Cefixime Approved, Investigational Phase 4,Phase 3,Not Applicable 79350-37-1 5362065 54362
7
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
8
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
9
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
10
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 114-07-8 12560
11
Albendazole Approved, Vet_approved Phase 4,Phase 3,Not Applicable 54965-21-8 2082
12
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 70288-86-7 6474909
13
Oxytetracycline Approved, Investigational, Vet_approved Phase 4 79-57-2 5280972
14
Tenofovir Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 147127-20-6 464205
15 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
16 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
17 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
19 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
20 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
24 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
25 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Phase 2,Not Applicable
27 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Contraceptive Agents Phase 4,Phase 3,Not Applicable
29 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
30 Erythromycin stearate Phase 4,Phase 3,Phase 2
31 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
32 Erythromycin Estolate Phase 4,Phase 3,Phase 2
33 Erythromycin Ethylsuccinate Phase 4,Phase 3,Phase 2
34 Aspartic Acid Phase 4,Phase 3
35 alanine Phase 4,Phase 3
36 N-Methylaspartate Phase 4,Phase 3
37 Antimitotic Agents Phase 4,Phase 3,Not Applicable
38 Anthelmintics Phase 4,Phase 3,Not Applicable
39 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Laxatives Phase 4,Phase 2
41 Carboxymethylcellulose Sodium Phase 4,Phase 2
42 Cathartics Phase 4,Phase 2
43
Ganciclovir Approved, Investigational Phase 3 82410-32-0 3454
44
Ethanol Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 64-17-5 702
45
Rifampicin Approved Phase 3,Phase 2 13292-46-1 5458213 5381226
46
Ceftriaxone Approved Phase 3,Phase 2,Not Applicable 73384-59-5 5479530 5361919
47
Metronidazole Approved Phase 3 443-48-1 4173
48 silver nitrate Approved, Investigational Phase 3
49
Estradiol Approved, Investigational, Vet_approved Phase 3,Not Applicable 50-28-2 5757
50
Ethinyl Estradiol Approved Phase 3,Not Applicable 57-63-6 5991

Interventional clinical trials:

(show top 50) (show all 310)
# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4 emtricitabine/tenofovir disoproxil fumarate
3 Washington State Community Expedited Partner Treatment (EPT) Trial Completed NCT01665690 Phase 4
4 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4 Azithromcyin;Azithromycin
5 Trachoma Amelioration in Northern Amhara (TANA) Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
6 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
7 Trachoma Elimination Follow-up Completed NCT00221364 Phase 4 Mass treatment with oral azithromycin to an entire village
8 Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania Completed NCT00347763 Phase 4
9 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
10 Microorganism in Overactive Bladder Patients Completed NCT00883818 Phase 4 azithromycin, doxycycline
11 Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
12 Doxycycline Prophylaxis at Vacuum Aspiration Trial Completed NCT00547170 Phase 4 Doxycycline pre-operatively;Doxycycline post-operatively
13 A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery Completed NCT00522860 Phase 4
14 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
15 Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania Completed NCT00347607 Phase 4
16 Stage Matched Intervention to Increase Dual Method Use Completed NCT00436306 Phase 4
17 Effectiveness of Integrating Prenatal Care in Reducing HIV/STDs Among Young Pregnant Women Completed NCT00628771 Phase 4
18 AZithromycin Against pLacebo in Exacerbations of Asthma Completed NCT01444469 Phase 4 Zithromax;Placebo
19 HPTN 073 Black Men Who Have Sex With Men (MSM) Pre-Exposure Prophylaxis (PrEP) Completed NCT01808352 Phase 4 FTC/TDF
20 PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5 Completed NCT02149888 Phase 4 Tenofovir/emtricitabine
21 Partnership for Rapid Elimination of Trachoma Completed NCT00792922 Phase 4 Azithromycin;Azithromycin
22 Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM Recruiting NCT03608774 Phase 4 Azithromycin;Doxycycline
23 Sanitation, Water, and Instruction in Face-washing for Trachoma Recruiting NCT02754583 Phase 4 Azithromycin;Tetracycline;Albendazole
24 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Recruiting NCT03233880 Phase 4 Azithromycin 1gm
25 Mortality Reduction After Oral Azithromycin: Morbidity Study Enrolling by invitation NCT02048007 Phase 4 Azithromycin;Placebo
26 Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection Not yet recruiting NCT03532464 Phase 4 azithromycin;doxycycline
27 Kebele Elimination of Trachoma for Ocular Health Not yet recruiting NCT03335072 Phase 4 Azithromycin
28 Trachoma Elimination Study by Focused Antibiotic (TESFA) Not yet recruiting NCT03523156 Phase 4 Azithromycin mass treatment;Azithromycin targeted treatment
29 Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin Not yet recruiting NCT03570814 Phase 4 Administration of Albendazole on Day 1;Administration of Ivermectin on Day 1;Administration of Azithromycin on Day 1;Administration of Azithromycin on Day 15
30 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
31 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4 Azithromycin
32 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
33 PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients Unknown status NCT00251849 Phase 3 Rifalazil
34 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
35 Identigene STD Test Collection Kit Validation Study Unknown status NCT01471392 Phase 3
36 Evaluate the Use of Ganciclovir Gel 0.3% for the Treatment of Conjunctivitis Caused by Adenovirus Unknown status NCT01600365 Phase 3 Ophthalmic gel (placebo);Ganciclovir
37 Partner Notification for Chlamydia in Primary Care Completed NCT00112255 Phase 3
38 Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin Completed NCT01113931 Phase 3 Doxycyline Hyclate tablet;Vibramycin (doxycyline hyclate) capsule
39 Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities Completed NCT00980148 Phase 3 Azithromycin;Doxycycline
40 Home Screening for Chlamydia Surveillance Completed NCT00177437 Phase 3
41 Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
42 Efficacy and Safety Study of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea Completed NCT02210325 Phase 3 solithromycin;ceftriaxone;azithromycin
43 Bacterial Vaginosis Home Screening to Prevent STDs Completed NCT00667368 Phase 3 Metronidazole
44 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
45 The CLARICOR Trial: Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease Completed NCT00121550 Phase 3 clarithromycin
46 ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study Completed NCT00245908 Phase 3 azithromycin
47 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
48 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3 PRO 2000/5;Placebo
49 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
50 HIV Prevention for African American Teens Completed NCT00279799 Phase 3

Search NIH Clinical Center for Chlamydia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Chlamydia

Anatomical Context for Chlamydia

MalaCards organs/tissues related to Chlamydia:

41
Testes, Endothelial, T Cells, Heart, Eye, Lung, Monocytes

Publications for Chlamydia

Articles related to Chlamydia:

(show top 50) (show all 3941)
# Title Authors Year
1
We need to consider collateral damage to resistomes when we decide how frequently to screen for chlamydia/gonorrhoea in preexposure prophylaxis cohorts. ( 30234609 )
2019
2
Adult conjunctivitis secondary to dual infection with Chlamydia trachomatis and Neisseria gonorrhoeae - A case report. ( 30505977 )
2019
3
Chlamydia pneumoniae infection promotes monocyte transendothelial migration by increasing vascular endothelial cell permeability via the tyrosine phosphorylation of VE-cadherin. ( 29462613 )
2018
4
Impact of screening on chlamydia infections. ( 29970588 )
2018
5
Impact of the Levonorgestrel-Releasing Intrauterine System on the Progression of Chlamydia trachomatis Infection to Pelvic Inflammatory Disease in a Baboon Model. ( 29253201 )
2018
6
Interferon-I^ interferes with host cell metabolism during intracellular Chlamydia trachomatis infection. ( 29885991 )
2018
7
Screening for Chlamydia trachomatis and Neisseria gonorrhoeae Infections in Men Who Have Sex With Men: Diagnostic Accuracy of Nucleic Acid Amplification Test on Pooled Urine, Anorectal, and Pharyngeal Specimens. ( 29419710 )
2018
8
The Chlamydia trachomatis PmpD adhesin forms higher order structures through disulphide-mediated covalent interactions. ( 29912892 )
2018
9
Diagnostic accuracy of a prototype rapid chlamydia and gonorrhoea recombinase polymerase amplification assay: a multi-centre cross-sectional pre-clinical evaluation. ( 29906594 )
2018
10
Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein (MOMP)-based Fusion Antigen CTH522 into Protein Nanoparticles. ( 29452143 )
2018
11
HPV and Chlamydia trachomatis coinfection in women with Pap smear abnormality: baseline data of the HPV Pathogen ISS study. ( 29932086 )
2018
12
Clinical signs of trachoma are prevalent among Solomon Islanders who have no persistent markers of prior infection with <i>Chlamydia trachomatis</i>. ( 29588922 )
2018
13
Chlamydia trachomatis paralyses neutrophils to evade the host innate immune response. ( 29946164 )
2018
14
Genital<i>Chlamydia trachomatis</i>infections in young adults - a school-based bio-behavioural study in urban areas, Poland, 2012 to 2015. ( 29439753 )
2018
15
Association of asymptomatic Chlamydia trachomatis infection with male infertility and the effect of antibiotic therapy in improvement of semen quality in infected infertile men. ( 29292525 )
2018
16
Observational study of anorectal Chlamydia trachomatis infections in France through the lymphogranuloma venereum surveillance network, 2010-2015. ( 29973128 )
2018
17
Preliminary evidence of the seroprevalence and risk factors associated with Chlamydia abortus infection in goats on the Canary Islands, Spain. ( 29980954 )
2018
18
Molecular mechanisms of Chlamydia trachomatis resistance to antimicrobial drugs. ( 28930567 )
2018
19
Detection of urinary Chlamydia trachomatis, Mycoplasma genitalium and human papilloma virus in the first trimester of pregnancy by PCR method. ( 29866110 )
2018
20
Effect of rectal douching/enema on rectal gonorrhoea and chlamydia among a cohort of men who have sex with men on HIV pre-exposure prophylaxis. ( 29907624 )
2018
21
Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein. ( 29964134 )
2018
22
Detection of<i>Chlamydia trachomatis</i>in rectal specimens in women and its association with anal intercourse: a systematic review and meta-analysis. ( 29431148 )
2018
23
Conjunctival transcriptome profiling of Solomon Islanders with active trachoma in the absence of Chlamydia trachomatis infection. ( 29467021 )
2018
24
Rising Chlamydia and Gonorrhoea Incidence and Associated Risk Factors Among Female Sex Workers in Australia: A Retrospective Cohort Study. ( 29420449 )
2018
25
Association of Chlamydia trachomatis infections with preterm delivery; a systematic review and meta-analysis. ( 29914397 )
2018
26
Repeat Chlamydia Diagnoses Increase the Hazard of Pelvic Inflammatory Disease among U.S. Army females: A Retrospective Cohort Analysis. ( 29870505 )
2018
27
Detection of Chlamydiaceae and Chlamydia-like organisms on the ocular surface of children and adults from a trachoma-endemic region. ( 29743637 )
2018
28
Plasmid Negative Regulation of CPAF Expression Is Pgp4 Independent and Restricted to Invasive<i>Chlamydia trachomatis</i>Biovars. ( 29382731 )
2018
29
Prevalence of<i>Chlamydia trachomatis</i>-Specific Antibodies before and after Mass Drug Administration for Trachoma in Community-Wide Surveys of Four Communities in Nepal. ( 29141720 )
2018
30
Barriers and Facilitators of Partner Treatment of Chlamydia: A Qualitative Investigation with Prescribers and Community Pharmacists. ( 29419807 )
2018
31
Chlamydia trachomatis genotypes A and B from urogenital specimens of patients in Spain: an organotropism-related gene and multilocus sequence typing study. ( 29427803 )
2018
32
Evaluation of the reproducibility of a serological test for antibodies to Chlamydia trachomatis pgp3: A potential surveillance tool for trachoma programs. ( 29501689 )
2018
33
Pathology after<i>Chlamydia trachomatis</i>infection is driven by nonprotective immune cells that are distinct from protective populations. ( 29440378 )
2018
34
Chlamydia trachomatis inhibits the production of pro-inflammatory cytokines in human PBMCs through induction of IL-10. ( 29388547 )
2018
35
Pelvic inflammatory disease risk following negative results from chlamydia nucleic acid amplification tests (NAATs) versus non-NAATs in Denmark: A retrospective cohort. ( 29293503 )
2018
36
Stimulated peripheral blood mononuclear cells from chlamydia-infected women release predominantly Th1-polarizing cytokines. ( 29914793 )
2018
37
Population-based analysis of ocular Chlamydia trachomatis in trachoma-endemic West African communities identifies genomic markers of disease severity. ( 29482619 )
2018
38
Association between Prior <i>Chlamydia trachomatis</i> Infection and Ectopic Pregnancy at a Tertiary Care Hospital in South Western Uganda. ( 29686708 )
2018
39
Transformation of Chlamydia: Current approaches and impact on our understanding of chlamydial infection biology. ( 29409975 )
2018
40
Overfilled urine specimens for gonorrhea and chlamydia testing: Implications for practice. ( 29422146 )
2018
41
Only recent sexual partners contribute to oropharyngeal gonorrhoea positivity: the number of sexual partners over different time periods as an indicator of gonorrhoea and chlamydia infection duration among men who have sex with men. ( 29973330 )
2018
42
Risk of Pelvic Inflammatory Disease in Relation to Chlamydia and Gonorrhea Testing, Repeat Testing, and Positivity: A Population-Based Cohort Study. ( 29136127 )
2018
43
Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease. ( 29426279 )
2018
44
Fitz-Hugh-Curtis syndrome in a man positive for Chlamydia trachomatis. ( 29417387 )
2018
45
Racial/ethnic disparities in the lifetime risk of Chlamydia trachomatis diagnosis and adverse reproductive health outcomes among women in King County, Washington. ( 29420716 )
2018
46
National prevalence estimates of chlamydia and gonorrhoea in the Netherlands. ( 29925670 )
2018
47
Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1I^ Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. ( 29937375 )
2018
48
Vaccination of koalas (Phascolarctos cinereus) against Chlamydia pecorum using synthetic peptides derived from the major outer membrane protein. ( 29953523 )
2018
49
An Online Risk Index for the Cross-Sectional Prediction of New HIV Chlamydia, and Gonorrhea Diagnoses Across U.S. Counties and Across Years. ( 29427233 )
2018
50
Prevalence of Chlamydia trachomatis in Pregnant Iranian Women: A Systematic Review and Meta-Analysis. ( 29935063 )
2018

Variations for Chlamydia

Expression for Chlamydia

Search GEO for disease gene expression data for Chlamydia.

Pathways for Chlamydia

Pathways related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.16 CASP1 CD79A CRP CXCL8 IFNG IL10
2
Show member pathways
13.97 CXCL8 IL10 IL1B IL4 IL6 MAPK14
3
Show member pathways
13.84 CASP1 CXCL8 IFNG IL10 IL1B IL4
4
Show member pathways
13.69 CXCL8 IFNG IL10 IL1B IL4 IL6
5
Show member pathways
13.59 CXCL8 IL10 IL1B IL4 IL6 MAPK14
6
Show member pathways
13.54 CASP1 CXCL8 IFNG IL10 IL1B IL4
7
Show member pathways
13.46 CASP1 CXCL8 IL10 IL1B IL4 IL6
8
Show member pathways
13.4 CD79A IFNG IL1B IL4 MAPK14 RAC1
9
Show member pathways
13.25 CXCL8 IL1B IL6 MAPK14 RAC1 RAF1
10
Show member pathways
13.18 IL4 IL6 MCL1 RAC1 RAF1 TLR2
11
Show member pathways
13.15 CASP1 CXCL8 IFNG IL10 IL1B IL6
12
Show member pathways
13.08 CXCL8 HSPD1 IFNG IL10 IL1B IL4
13
Show member pathways
13.06 CASP1 IL6 MAPK14 RAC1 RAF1 TNF
14
Show member pathways
13.04 MAPK14 NECTIN1 NOS2 RAC1 RAF1 TNF
15
Show member pathways
13.03 CASP1 CD79A MAPK14 RAC1 RAF1 TNF
16 13.01 CXCL8 IFNG IL4 IL6 NOS2 RAC1
17
Show member pathways
12.97 CASP1 CXCL8 IFNG IL1B IL6 MAPK14
18 12.91 CASP1 IL1B MAPK14 RAC1 RAF1 TNF
19
Show member pathways
12.9 CASP1 CXCL8 IFNG IL1B IL4 IL6
20
Show member pathways
12.87 IL4 IL6 RAC1 RAF1 TNF
21
Show member pathways
12.83 IFNG IL1B MAPK14 MCL1 RAF1 TNF
22
Show member pathways
12.83 CD79A IFNG IL10 IL4 RAC1 RAF1
23
Show member pathways
12.83 CASP1 IL1B MAPK14 RAC1 RAF1 TLR2
24
Show member pathways
12.81 IL1B IL6 TLR2 TLR4 TNF
25
Show member pathways
12.8 IFNG IL10 IL1B IL6 MAPK14 NOS2
26 12.78 CD79A IDO1 IFNG IL10 IL1B IL4
27
Show member pathways
12.77 IFNG IL10 IL1B IL4 IL6 MAPK14
28
Show member pathways
12.76 CD79A IL4 MAPK14 RAC1 RAF1 TNF
29
Show member pathways
12.65 IFNG IL4 RAC1 RAF1 TNF
30
Show member pathways
12.65 IFNG IL10 IL1B IL4 IL6 MAPK14
31
Show member pathways
12.62 IL1B MAPK14 NOS2 RAC1 RAF1
32
Show member pathways
12.58 IFNG IL10 IL4 IL6 MCL1 RAF1
33
Show member pathways
12.55 MAPK14 RAC1 RAF1 TLR2 TLR4
34
Show member pathways
12.55 CXCL8 IFNG IL1B IL4 IL6 MAPK14
35
Show member pathways
12.54 CRP IFNG IL1B IL4 IL6 TNF
36 12.51 MAPK14 RAC1 RAF1 TLR2 TLR4 TNF
37
Show member pathways
12.5 CXCL8 MAPK14 NOS2 RAC1 RAF1
38
Show member pathways
12.49 MAPK14 NOS2 RAC1 RAF1
39
Show member pathways
12.48 CXCL8 IFNG IL10 IL1B IL4 IL6
40
Show member pathways
12.47 CD79A MAPK14 RAC1 RAF1
41 12.46 IL6 MAPK14 RAC1 TLR2 TNF
42
Show member pathways
12.45 CXCL8 IL1B IL6 MAPK14 NOS2 RAF1
43
Show member pathways
12.45 CXCL8 IFNG IL1B IL6 MAPK14 NOS2
44
Show member pathways
12.43 MAPK14 RAF1 TLR2 TLR4
45
Show member pathways
12.43 CXCL8 IL6 TLR2 TLR4 TNF
46
Show member pathways
12.43 CASP1 IL10 IL1B IL6 MAPK14 RAF1
47
Show member pathways
12.42 IFNG IL10 IL1B IL4 MAPK14 NOS2
48 12.41 IFNG IL6 NOS2 TLR2 TLR4 TNF
49
Show member pathways
12.4 IFNG IL6 MAPK14 RAC1
50 12.4 CXCL8 HSPD1 IL10 IL1B IL6 TNF

GO Terms for Chlamydia

Cellular components related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CRP CXCL8 HSPD1 IFNG IL10 IL1B
2 membrane raft GO:0045121 9.56 CD79A HSPD1 TLR2 TNF
3 extracellular region GO:0005576 9.32 CRP CXCL8 IFNG IL10 IL1B IL4
4 lipopolysaccharide receptor complex GO:0046696 9.16 HSPD1 TLR4

Biological processes related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Name GO ID Score Top Affiliating Genes
1 cellular response to interferon-gamma GO:0071346 9.98 CASP1 NOS2 TLR2 TLR4
2 defense response to Gram-positive bacterium GO:0050830 9.98 CRP IL6 TLR2 TNF
3 cellular response to mechanical stimulus GO:0071260 9.96 CASP1 IL1B RAC1 TLR4
4 positive regulation of inflammatory response GO:0050729 9.96 HSPD1 TLR2 TLR4 TNF
5 positive regulation of JNK cascade GO:0046330 9.93 IL1B TLR4 TNF
6 regulation of insulin secretion GO:0050796 9.93 IFNG IL1B NOS2 TNF
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.92 IL6 RAF1 TNF
8 B cell differentiation GO:0030183 9.92 CD79A IL10 IL4
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 IFNG IL4 IL6
10 apoptotic signaling pathway GO:0097190 9.91 CASP1 TLR4 TNF
11 positive regulation of T cell proliferation GO:0042102 9.91 IL1B IL4 IL6
12 humoral immune response GO:0006959 9.91 IFNG IL6 TNF
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 IL1B TLR2 TLR4 TNF
14 response to glucocorticoid GO:0051384 9.91 HSPD1 IL10 IL1B IL6 TNF
15 cytokine-mediated signaling pathway GO:0019221 9.91 CASP1 CXCL8 IL10 IL1B IL4 IL6
16 cellular response to organic substance GO:0071310 9.9 CASP1 IL1B MAPK14
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.89 IL1B MCL1 TNF
18 B cell proliferation GO:0042100 9.88 CD79A HSPD1 IL10
19 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.88 HSPD1 TLR2 TLR4
20 positive regulation of interferon-gamma production GO:0032729 9.88 HSPD1 IL1B TLR4 TNF
21 B cell activation GO:0042113 9.87 CD79A HSPD1 IL4
22 negative regulation of interleukin-6 production GO:0032715 9.87 IL10 TLR4 TNF
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 IFNG IL1B TLR4 TNF
24 negative regulation of neurogenesis GO:0050768 9.86 IL1B IL6 TNF
25 positive regulation of interleukin-10 production GO:0032733 9.85 HSPD1 TLR2 TLR4
26 positive regulation of neutrophil chemotaxis GO:0090023 9.85 CXCL8 IL1B RAC1
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 IL1B MAPK14 TLR2 TLR4 TNF
28 positive regulation of interleukin-6 production GO:0032755 9.85 HSPD1 IL1B IL6 TLR2 TLR4 TNF
29 positive regulation of glial cell proliferation GO:0060252 9.83 IL1B IL6 TNF
30 positive regulation of interleukin-8 production GO:0032757 9.83 IL1B TLR2 TLR4 TNF
31 positive regulation of macrophage activation GO:0043032 9.82 HSPD1 IL10 TLR4
32 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.82 IFNG IL1B TNF
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 IL10 IL1B TNF
34 positive regulation of interleukin-12 production GO:0032735 9.8 HSPD1 IDO1 IFNG TLR2 TLR4
35 response to molecule of bacterial origin GO:0002237 9.79 CXCL8 IL10 TLR2
36 positive regulation of chemokine production GO:0032722 9.78 IL6 TLR2 TLR4 TNF
37 cellular response to lipoteichoic acid GO:0071223 9.77 MAPK14 TLR2 TLR4
38 negative regulation of lipid storage GO:0010888 9.76 CRP IL6 TNF
39 response to lipopolysaccharide GO:0032496 9.76 HSPD1 IDO1 IL10 IL1B MAPK14 NOS2
40 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.75 TLR4 TNF
41 death-inducing signaling complex assembly GO:0071550 9.74 RAF1 TNF
42 endothelial cell apoptotic process GO:0072577 9.74 IL10 TNF
43 positive regulation of chemokine biosynthetic process GO:0045080 9.74 IL1B TNF
44 regulation of establishment of endothelial barrier GO:1903140 9.73 IL1B TNF
45 negative regulation of cytokine secretion involved in immune response GO:0002740 9.73 IL10 TNF
46 positive regulation of fever generation GO:0031622 9.73 IL1B TNF
47 regulation of cytokine production involved in inflammatory response GO:1900015 9.73 MAPK14 NOS2
48 chronic inflammatory response to antigenic stimulus GO:0002439 9.72 IL1B TNF
49 positive regulation of killing of cells of other organism GO:0051712 9.72 IFNG NOS2
50 regulation of isotype switching GO:0045191 9.72 IL10 IL4

Molecular functions related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 CASP1 CD79A CRP CXCL8 HSPD1 IFNG
2 identical protein binding GO:0042802 9.91 CASP1 CRP NECTIN1 RAF1 TLR2 TLR4
3 protein heterodimerization activity GO:0046982 9.63 HSPD1 MCL1 NECTIN1 RAF1 TLR2 TLR4
4 lipopolysaccharide binding GO:0001530 9.43 HSPD1 TLR2 TLR4
5 virion binding GO:0046790 9.4 CRP NECTIN1
6 lipopolysaccharide receptor activity GO:0001875 9.32 TLR2 TLR4
7 cytokine activity GO:0005125 9.17 CXCL8 IFNG IL10 IL1B IL4 IL6

Sources for Chlamydia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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