Aliases & Classifications for Chlamydia

MalaCards integrated aliases for Chlamydia:

Name: Chlamydia 12 77 3 15
Chlamydial Infection 12 56 15
Chlamydia Trachomatis Infectious Disease 12 17
Chlamydia Infections 74
Chlamydial Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11263
ICD10 34 A56.2 A74.9
UMLS 74 C0008149

Summaries for Chlamydia

CDC : 3 Most people who have chlamydia don't know it since the disease often has no symptoms.

MalaCards based summary : Chlamydia, also known as chlamydial infection, is related to trachoma and pelvic inflammatory disease, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Chlamydia is YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A commensal bacterial infectious disease that is caused by Chlamydia trachomatis.

Wikipedia : 77 Chlamydia infection, often simply known as chlamydia, is a sexually transmitted infection caused by the... more...

Related Diseases for Chlamydia

Diseases related to Chlamydia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 610)
# Related Disease Score Top Affiliating Genes
1 trachoma 33.1 HSPD1 IDO1 IL10 TNF
2 pelvic inflammatory disease 32.5 CRP HSPD1 TLR2 TLR4
3 reactive arthritis 32.4 CRP HSPD1 IFNG IL10 TNF
4 conjunctivitis 31.5 CXCL8 IFNG IL6
5 salpingitis 31.3 CRP HSPD1 TNF
6 arteries, anomalies of 31.2 CRP IL1B IL6 TNF
7 endometritis 31.0 IL1B IL6 TNF
8 arthritis 30.9 CXCL8 IFNG IL10 IL1B IL6 TNF
9 asthma 30.9 CXCL8 IFNG IL10 IL1B IL6 TNF
10 keratoconjunctivitis 30.9 CXCL8 IFNG TNF
11 prostatitis 30.8 CXCL8 IL10 IL1B IL6 TNF
12 heart disease 30.8 CRP CXCL8 IL10 IL1B IL6 TNF
13 ischemic heart disease 30.8 CRP IL6 TNF
14 bronchitis 30.6 CRP CXCL8 TNF
15 pharyngitis 30.6 CRP CXCL8 IL1B
16 pneumonia 30.6 CRP CXCL8 IL10 IL1B IL6 TLR2
17 uveitis 30.5 IFNG IL10 TNF
18 cytomegalovirus infection 30.4 CXCL8 IL1B IL6 TNF
19 bacterial vaginosis 30.4 CXCL8 IL1B IL6 TLR2 TLR4 TNF
20 multiple sclerosis 30.4 IFNG IL10 IL1B IL6 NOS2 TNF
21 spondyloarthropathy 1 30.3 CRP TLR4 TNF
22 spondylitis 30.3 CRP IL6 TNF
23 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.3 HSPD1 IFNG IL10
24 vascular disease 30.3 CRP HSPD1 IL6 NOS2 TNF
25 myocarditis 30.3 IL6 NOS2 TNF
26 relapsing-remitting multiple sclerosis 30.3 IFNG IL10 TNF
27 neuritis 30.2 IFNG IL1B TNF
28 cerebrovascular disease 30.2 CRP IL6 TLR4 TNF
29 mycobacterium chelonae 30.2 CXCL8 TLR2
30 temporal arteritis 30.2 CRP IFNG IL6 TNF
31 chronic fatigue syndrome 30.2 IL10 IL1B IL6 TNF
32 atherosclerosis susceptibility 30.1 CRP IL6 TLR4 TNF
33 hemophagocytic lymphohistiocytosis 30.1 CXCL8 IFNG IL10 TNF
34 pulmonary disease, chronic obstructive 30.1 CRP CXCL8 IL6 MAPK14 TLR2 TNF
35 vulvovaginitis 30.1 CXCL8 HSPD1 IL10
36 spondyloarthropathy 30.1 IFNG IL10 IL6 TNF
37 sudden infant death syndrome 30.1 IL10 IL1B IL6 TNF
38 schistosomiasis 30.1 IFNG IL10 TNF
39 avian influenza 30.1 CXCL8 IL6 TNF
40 poliomyelitis 30.0 IFNG IL10 TNF
41 pertussis 30.0 IL10 IL1B IL6 TLR4 TNF
42 rosacea 30.0 IL6 TLR2 TNF
43 vaginitis 30.0 CXCL8 IL1B IL6
44 acute cystitis 30.0 CRP CXCL8 IL6
45 kawasaki disease 30.0 CRP HSPD1 IL10 IL6 TNF
46 campylobacteriosis 30.0 IFNG IL1B TLR4
47 urinary system disease 30.0 CRP IL6 TNF
48 listeriosis 30.0 IDO1 IL6 TNF
49 cholangitis 30.0 CRP IL6 TNF
50 cystitis 29.9 CRP CXCL8 IL6 TLR4 TNF

Graphical network of the top 20 diseases related to Chlamydia:



Diseases related to Chlamydia

Symptoms & Phenotypes for Chlamydia

UMLS symptoms related to Chlamydia:


fever, pruritus, pelvic pain

GenomeRNAi Phenotypes related to Chlamydia according to GeneCards Suite gene sharing:

27 (show all 36)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.49 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.49 MAPK14 YWHAB
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.49 MAPK14
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.49 IL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.49 RAF1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.49 YWHAB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.49 CRP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.49 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.49 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-129 10.49 YWHAB
11 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.49 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-133 10.49 MAPK14 YWHAB
13 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.49 MAPK14 YWHAB
14 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.49 CRP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.49 RAF1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.49 RAF1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.49 IL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.49 CRP IL10 MAPK14 RAF1 YWHAB
19 Increased shRNA abundance (Z-score > 2) GR00366-A-182 10.49 MAPK14
20 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.49 IL10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.49 IL10 YWHAB
22 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.49 IL10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.49 IL10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.49 YWHAB
25 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.49 CRP
26 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.49 IL10 RAF1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.49 CRP MAPK14
28 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.49 IL10
29 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.49 IL10
30 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10.49 IL10
31 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.49 IL10
32 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.49 IL10 MAPK14
33 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 CASP1 CXCL8 IL10 IL1B MCL1 NOS2
34 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 CASP1 CXCL8 IL10 IL1B MCL1 NOS2
35 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 9.65 MAPK14 MCL1 NOS2 RAC1 RAF1
36 Reduced mammosphere formation GR00396-S 9.5 CASP1 CD79A CXCL8 HSPD1 IDO1 RAC1

MGI Mouse Phenotypes related to Chlamydia:

47 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.47 CASP1 CD79A HSPD1 IDO1 IFNG IL10
2 cardiovascular system MP:0005385 10.44 CASP1 CRP IDO1 IFNG IL10 IL1B
3 homeostasis/metabolism MP:0005376 10.43 CASP1 CD79A CRP IDO1 IFNG IL10
4 hematopoietic system MP:0005397 10.41 CASP1 CD79A IDO1 IFNG IL10 IL1B
5 immune system MP:0005387 10.41 CASP1 CD79A CRP IDO1 IFNG IL10
6 growth/size/body region MP:0005378 10.36 HSPD1 IFNG IL10 IL1B IL6 MAPK14
7 behavior/neurological MP:0005386 10.35 HSPD1 IFNG IL10 IL6 MAPK14 NECTIN1
8 integument MP:0010771 10.34 CASP1 IFNG IL10 IL1B IL6 MAPK14
9 mortality/aging MP:0010768 10.33 CASP1 HSPD1 IFNG IL10 IL1B IL6
10 endocrine/exocrine gland MP:0005379 10.3 CASP1 IFNG IL10 IL6 MAPK14 MCL1
11 muscle MP:0005369 10.21 HSPD1 IDO1 IFNG IL10 IL6 MAPK14
12 nervous system MP:0003631 10.21 CASP1 CD79A HSPD1 IFNG IL10 IL1B
13 craniofacial MP:0005382 10.19 IFNG IL10 IL1B NECTIN1 NOS2 RAC1
14 digestive/alimentary MP:0005381 10.18 CASP1 IFNG IL10 IL6 NOS2 TLR2
15 liver/biliary system MP:0005370 10.18 CD79A IFNG IL10 IL6 MAPK14 NOS2
16 neoplasm MP:0002006 10.18 CASP1 CD79A IFNG IL10 IL1B IL6
17 embryo MP:0005380 10.17 HSPD1 IFNG IL10 MAPK14 MCL1 RAC1
18 reproductive system MP:0005389 10.03 CASP1 HSPD1 IDO1 IFNG IL10 IL6
19 renal/urinary system MP:0005367 9.92 CASP1 CD79A IDO1 IFNG IL6 NOS2
20 respiratory system MP:0005388 9.81 IFNG IL10 IL6 MAPK14 NOS2 RAF1
21 skeleton MP:0005390 9.7 IFNG IL10 IL1B IL6 MAPK14 NECTIN1
22 vision/eye MP:0005391 9.23 IFNG IL10 IL6 NECTIN1 NOS2 RAF1

Drugs & Therapeutics for Chlamydia

Drugs for Chlamydia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 210)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 83905-01-5 447043 55185
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 564-25-0 54671203
3
Tetracycline Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 60-54-8 5353990
4
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
5
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 143491-57-0 60877
6
Tenofovir Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 147127-20-6 464205
7
Cefixime Approved, Investigational Phase 4,Phase 3,Not Applicable 79350-37-1 5362065 54362
8
Permethrin Approved, Investigational Phase 4,Phase 2 52645-53-1 40326
9
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
10
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
11
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 114-07-8 441411 12560
12
Albendazole Approved, Vet_approved Phase 4,Phase 3,Not Applicable 54965-21-8 2082
13
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 70288-86-7 6474909
14
Oxytetracycline Approved, Investigational, Vet_approved Phase 4 79-57-2 54715139 5280972
15 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
16 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
19 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
20 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Phase 2,Not Applicable
24 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
25 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
27 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Contraceptive Agents Phase 4,Phase 3,Not Applicable
29 Erythromycin Ethylsuccinate Phase 4,Phase 3,Phase 2
30 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
31 Erythromycin Estolate Phase 4,Phase 3,Phase 2
32 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
33 Erythromycin stearate Phase 4,Phase 3,Phase 2
34 alanine Phase 4,Phase 3
35 N-Methylaspartate Phase 4,Phase 3
36 Aspartic Acid Phase 4,Phase 3
37 Anthelmintics Phase 4,Phase 3,Not Applicable
38 Antimitotic Agents Phase 4,Phase 3,Not Applicable
39 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Laxatives Phase 4,Phase 2
41 Cathartics Phase 4,Phase 2
42 Carboxymethylcellulose Sodium Phase 4,Phase 2
43
Ganciclovir Approved, Investigational Phase 3 82410-32-0 3454
44
Ethanol Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 64-17-5 702
45
Rifampicin Approved Phase 3,Phase 2 13292-46-1 5381226 5458213
46
Ceftriaxone Approved Phase 3,Phase 2,Not Applicable 73384-59-5 5479530 5361919
47
Metronidazole Approved Phase 3 443-48-1 4173
48 silver nitrate Approved, Investigational Phase 3
49
Ethinyl Estradiol Approved Phase 3,Not Applicable 57-63-6 5991
50
Polyestradiol phosphate Approved Phase 3,Not Applicable 28014-46-2

Interventional clinical trials:

(show top 50) (show all 321)
# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4 emtricitabine/tenofovir disoproxil fumarate
3 Washington State Community Expedited Partner Treatment (EPT) Trial Completed NCT01665690 Phase 4
4 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4 Azithromcyin;Azithromycin
5 Trachoma Amelioration in Northern Amhara (TANA) Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
6 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
7 Trachoma Elimination Follow-up Completed NCT00221364 Phase 4 Mass treatment with oral azithromycin to an entire village
8 Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania Completed NCT00347763 Phase 4
9 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
10 Microorganism in Overactive Bladder Patients Completed NCT00883818 Phase 4 azithromycin, doxycycline
11 Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
12 Doxycycline Prophylaxis at Vacuum Aspiration Trial Completed NCT00547170 Phase 4 Doxycycline pre-operatively;Doxycycline post-operatively
13 A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery Completed NCT00522860 Phase 4
14 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
15 Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania Completed NCT00347607 Phase 4
16 Stage Matched Intervention to Increase Dual Method Use Completed NCT00436306 Phase 4
17 Effectiveness of Integrating Prenatal Care in Reducing HIV/STDs Among Young Pregnant Women Completed NCT00628771 Phase 4
18 AZithromycin Against pLacebo in Exacerbations of Asthma Completed NCT01444469 Phase 4 Zithromax;Placebo
19 HPTN 073 Black Men Who Have Sex With Men (MSM) Pre-Exposure Prophylaxis (PrEP) Completed NCT01808352 Phase 4 FTC/TDF
20 PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5 Completed NCT02149888 Phase 4 Tenofovir/emtricitabine
21 Partnership for Rapid Elimination of Trachoma Completed NCT00792922 Phase 4 Azithromycin;Azithromycin
22 Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM Recruiting NCT03608774 Phase 4 Azithromycin;Doxycycline
23 Sanitation, Water, and Instruction in Face-washing for Trachoma Recruiting NCT02754583 Phase 4 Azithromycin;Tetracycline;Albendazole
24 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Recruiting NCT03233880 Phase 4 Azithromycin 1gm
25 Mortality Reduction After Oral Azithromycin: Morbidity Study Enrolling by invitation NCT02048007 Phase 4 Azithromycin;Placebo
26 Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection Not yet recruiting NCT03532464 Phase 4 azithromycin;doxycycline
27 Kebele Elimination of Trachoma for Ocular Health Not yet recruiting NCT03335072 Phase 4 Azithromycin
28 Trachoma Elimination Study by Focused Antibiotic (TESFA) Not yet recruiting NCT03523156 Phase 4 Azithromycin mass treatment;Azithromycin targeted treatment
29 Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin Not yet recruiting NCT03570814 Phase 4 Administration of Albendazole on Day 1;Administration of Ivermectin on Day 1;Administration of Azithromycin on Day 1;Administration of Azithromycin on Day 15
30 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
31 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4 Azithromycin
32 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
33 PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients Unknown status NCT00251849 Phase 3 Rifalazil
34 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
35 Identigene STD Test Collection Kit Validation Study Unknown status NCT01471392 Phase 3
36 Evaluate the Use of Ganciclovir Gel 0.3% for the Treatment of Conjunctivitis Caused by Adenovirus Unknown status NCT01600365 Phase 3 Ophthalmic gel (placebo);Ganciclovir
37 Partner Notification for Chlamydia in Primary Care Completed NCT00112255 Phase 3
38 Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin Completed NCT01113931 Phase 3 Doxycyline Hyclate tablet;Vibramycin (doxycyline hyclate) capsule
39 Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities Completed NCT00980148 Phase 3 Azithromycin;Doxycycline
40 Home Screening for Chlamydia Surveillance Completed NCT00177437 Phase 3
41 Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
42 Efficacy and Safety Study of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea Completed NCT02210325 Phase 3 solithromycin;ceftriaxone;azithromycin
43 Bacterial Vaginosis Home Screening to Prevent STDs Completed NCT00667368 Phase 3 Metronidazole
44 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
45 The CLARICOR Trial: Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease Completed NCT00121550 Phase 3 clarithromycin
46 ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study Completed NCT00245908 Phase 3 azithromycin
47 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
48 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3 PRO 2000/5;Placebo
49 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
50 HIV Prevention for African American Teens Completed NCT00279799 Phase 3

Search NIH Clinical Center for Chlamydia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Chlamydia

Anatomical Context for Chlamydia

MalaCards organs/tissues related to Chlamydia:

42
Testes, Heart, T Cells, Lung, Prostate, Endothelial, Eye

Publications for Chlamydia

Articles related to Chlamydia:

(show top 50) (show all 6766)
# Title Authors Year
1
Modulation of Host Cell Metabolism by Chlamydia trachomatis. ( 31111817 )
2019
2
Antibiotics for treating urogenital Chlamydia trachomatis infection in men and non-pregnant women. ( 30682211 )
2019
3
Anti-chlamydia IgG and IgA are insufficient to prevent endometrial chlamydia infection in women, and increased anti-chlamydia IgG is associated with enhanced risk for incident infection. ( 30784128 )
2019
4
Does infection with Chlamydia trachomatis induce long-lasting partial immunity? Insights from mathematical modelling. ( 30181327 )
2019
5
The Burden of Human Papillomavirus and Chlamydia trachomatis Coinfection in Women: A Large Cohort Study in Inner Mongolia, China. ( 30192954 )
2019
6
Where Do People Go for Gonorrhea and Chlamydia Tests: A Cross-Sectional View of the Central Indiana Population, 2003-2014. ( 30334869 )
2019
7
Activation of caspase-3 during Chlamydia trachomatis-induced apoptosis at a late stage. ( 30336068 )
2019
8
STI with Mycoplasma genitalium-more common than Chlamydia trachomatis in patients attending youth clinics in Sweden. ( 30327896 )
2019
9
Chlamydia trachomatis targets mitochondrial dynamics to promote intracellular survival and proliferation. ( 30311994 )
2019
10
Vaginal Gel Component Hydroxyethyl Cellulose Significantly Enhances the Infectivity of Chlamydia trachomatis Serovars D and E. ( 30373805 )
2019
11
Severe Conjunctivitis Associated with Chlamydia felis Infection in a Free-ranging Eurasian Lynx ( Lynx lynx). ( 30376393 )
2019
12
Assessing local chlamydia screening performance by combining survey and administrative data to account for differences in local population characteristics. ( 31068656 )
2019
13
Evaluating the Impact of Housing Status on Gonorrhea and Chlamydia Screening in an HIV Primary Care Setting. ( 30383619 )
2019
14
Comment on: 'Association of Chlamydia trachomatis ompA genovar with trachoma phenotypes'. ( 30390052 )
2019
15
Tumor necrosis factor receptor superfamily members 1a and 1b contribute to exacerbation of atherosclerosis by Chlamydia pneumoniae in mice. ( 30292879 )
2019
16
No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis. ( 30392431 )
2019
17
New evidence for domesticated animals as reservoirs of Chlamydia-associated community-acquired pneumonia. ( 30394363 )
2019
18
Chlamydia, Gonorrhea, and Human Immunodeficiency Virus Infection Among Transgender Women and Transgender Men Attending Clinics that Provide Sexually Transmitted Disease Services in Six US Cities: Results From the Sexually Transmitted Disease Surveillance Network. ( 30278030 )
2019
19
Localization and characterization of a putative cysteine desulfurase in Chlamydia psittaci. ( 30260037 )
2019
20
Prevalence and correlates of and a risk score to identify asymptomatic anorectal gonorrhoea and chlamydia infection among men who have sex with men in Kisumu, Kenya. ( 30242143 )
2019
21
We need to consider collateral damage to resistomes when we decide how frequently to screen for chlamydia/gonorrhoea in preexposure prophylaxis cohorts. ( 30234609 )
2019
22
Do healthcare professionals and young adults know about the National Chlamydia Screening Programme? Findings from two cross-sectional surveys. ( 30231833 )
2019
23
A microbial game of whack-a-mole: clinical case series of the urethral uncloaking phenomenon caused by Corynebacterium glucuronolyticum in men treated for Chlamydia trachomatis urethritis. ( 30168068 )
2019
24
Chlamydia trachomatis plasmid-encoded protein Pgp3 inhibits apoptosis via the PI3K-AKT-mediated MDM2-p53 axis. ( 30132214 )
2019
25
Detection of Chlamydia trachomatis and Neisseria gonorrhoeae with the cobas CT/NG v2.0 test: performance compared with the BD ProbeTec CT Qx and GC Qx amplified DNA and Aptima AC2 assays. ( 30126947 )
2019
26
Suspected gonorrhea and chlamydia: Incidence and utilization of empiric antibiotics in a health system emergency department. ( 30119987 )
2019
27
A diagnostic evaluation of a molecular assay used for testing and treating anorectal chlamydia and gonorrhoea infections at the point-of-care in Papua New Guinea. ( 30107282 )
2019
28
Has the increasing incidence of chlamydia and gonorrhoea resulted in increased chlamydial and gonococcal conjunctivitis presentations? Results from Melbourne, Australia, from 2000 to 2017. ( 30098131 )
2019
29
Biofilm in Genital Ecosystem: A Potential Risk Factor for Chlamydia trachomatis Infection. ( 30805068 )
2019
30
Association of Chlamydia trachomatis, C. pneumoniae, and IL-6 and IL-8 Gene Alterations With Heart Diseases. ( 30804931 )
2019
31
Chlamydia trachomatis Growth and Cytokine mRNA Response in a Prostate Cancer Cell Line. ( 30800160 )
2019
32
Genital Infiltrations of CD4+ and CD8+ T Lymphocytes, IgA+ and IgG+ Plasma Cells and Intra-Mucosal Lymphoid Follicles Associate With Protection Against Genital Chlamydiatrachomatis Infection in Minipigs Intramuscularly Immunized With UV-Inactivated Bacteria Adjuvanted With CAF01. ( 30800114 )
2019
33
Leveraging Informatics to Identify Reportable Cases: Pilot Findings on Electronic Case Reporting of Chlamydia and Gonorrhea. ( 30789599 )
2019
34
High prevalence of Chlamydia trachomatis in pregnant women attended at Primary Health Care services in Amazon, Brazil. ( 30785560 )
2019
35
Chlamydia trachomatis infection among patients attending sexual and reproductive health clinics: A cross-sectional study in Bao'an District, Shenzhen, China. ( 30779755 )
2019
36
Risk of ectopic pregnancy and tubal infertility following gonorrhoea and chlamydia infections. ( 30778532 )
2019
37
Temporal Patterns in Chlamydia Repeat Testing in Massachusetts. ( 30777163 )
2019
38
Seventy Years of Chlamydia Vaccine Research - Limitations of the Past and Directions for the Future. ( 30766521 )
2019
39
Randomized, open-label, multicenter study of azithromycin compared with doxycycline for treating anorectal Chlamydia trachomatis infection concomitant to a vaginal infection (CHLAZIDOXY study). ( 30762806 )
2019
40
Chlamydia trachomatis in women with pelvic inflammatory disease (PID): report from a tertiary center in eastern Nepal. ( 30755106 )
2019
41
Chlamydia pneumoniae enhances Interleukin 8 (IL-8) production with reduced azithromycin sensitivity under hypoxia. ( 30746791 )
2019
42
Targeted advertisement of chlamydia screening on social media: A mixed-methods analysis. ( 30746155 )
2019
43
Presumptive and Follow-up Treatment for Gonorrhea and Chlamydia Among Patients Attending Public Health Department Clinics in Virginia, 2016. ( 30742592 )
2019
44
Standardisation is necessary in urogenital and extragenital Chlamydia trachomatis bacterial load determination by quantitative PCR: a review of literature and retrospective study. ( 30733424 )
2019
45
A rare case of Fitz-Hugh-Curtis syndrome caused by Chlamydia trachomatis in an HIV-positive male patient. ( 30728975 )
2019
46
Concurrent and time-lagged effects of social disorganization on chlamydia rate trajectories among United States counties and the District of Columbia, 2010-2015. ( 30720674 )
2019
47
Autophagy induction and PDGFR-β knockdown by siRNA-encapsulated nanoparticles reduce chlamydia trachomatis infection. ( 30718536 )
2019
48
Optimization of a rapid test for antibodies to the Chlamydia trachomatis antigen Pgp3. ( 30709562 )
2019
49
Round pneumonia due to Chlamydia pneumoniae in a child. ( 30701012 )
2019
50
Young people's preferences for the use of emerging technologies for asymptomatic regular chlamydia testing and management: a discrete choice experiment in England. ( 30700477 )
2019

Variations for Chlamydia

Expression for Chlamydia

Search GEO for disease gene expression data for Chlamydia.

Pathways for Chlamydia

Pathways related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 CASP1 CD79A CRP CXCL8 IFNG IL10
2
Show member pathways
13.83 CASP1 CXCL8 IFNG IL10 IL1B IL6
3
Show member pathways
13.66 CXCL8 IFNG IL10 IL1B IL6 MAPK14
4
Show member pathways
13.57 CXCL8 IL10 IL1B IL6 MAPK14 RAC1
5
Show member pathways
13.53 CASP1 CXCL8 IFNG IL10 IL1B IL6
6
Show member pathways
13.42 CASP1 CXCL8 IL10 IL1B IL6 NECTIN1
7
Show member pathways
13.37 CD79A IFNG IL1B MAPK14 RAC1 RAF1
8
Show member pathways
13.15 IL6 MCL1 RAC1 RAF1 TLR2 TLR4
9
Show member pathways
13.15 CASP1 CXCL8 IFNG IL10 IL1B IL6
10
Show member pathways
13.13 CXCL8 IL1B IL6 MAPK14 RAC1 RAF1
11
Show member pathways
13.08 CASP1 IL6 MAPK14 RAC1 RAF1 TNF
12
Show member pathways
13.06 CXCL8 HSPD1 IFNG IL10 IL1B IL6
13
Show member pathways
13.04 MAPK14 NECTIN1 NOS2 RAC1 RAF1 TNF
14
Show member pathways
13.03 CASP1 CD79A MAPK14 RAC1 RAF1 TNF
15 12.97 CXCL8 IFNG IL6 NOS2 RAC1 RAF1
16
Show member pathways
12.95 CASP1 CXCL8 IFNG IL1B IL6 MAPK14
17
Show member pathways
12.9 CASP1 MCL1 RAF1 TNF YWHAB
18 12.9 CASP1 IL1B MAPK14 RAC1 RAF1 TNF
19
Show member pathways
12.82 IFNG IL1B MAPK14 MCL1 RAF1 TNF
20
Show member pathways
12.8 IL1B IL6 TLR2 TLR4 TNF
21
Show member pathways
12.8 CASP1 IL1B MAPK14 RAC1 RAF1 TLR2
22
Show member pathways
12.78 IFNG IL10 IL1B IL6 MAPK14 NOS2
23
Show member pathways
12.77 CD79A IFNG IL10 RAC1 RAF1 TNF
24 12.76 CD79A IDO1 IFNG IL10 IL1B TLR2
25
Show member pathways
12.76 IFNG IL10 IL1B IL6 MAPK14 RAF1
26
Show member pathways
12.76 IFNG IL10 IL1B IL6 MAPK14 MCL1
27
Show member pathways
12.71 CD79A MAPK14 RAC1 RAF1 TNF
28
Show member pathways
12.62 IL1B MAPK14 NOS2 RAC1 RAF1
29
Show member pathways
12.54 MAPK14 RAC1 RAF1 TLR2 TLR4
30
Show member pathways
12.53 IFNG IL10 IL6 MCL1 RAF1
31
Show member pathways
12.53 CXCL8 IFNG IL1B IL6 MAPK14 TLR2
32
Show member pathways
12.49 CXCL8 MAPK14 NOS2 RAC1 RAF1
33 12.49 MAPK14 RAC1 RAF1 TLR2 TLR4 TNF
34
Show member pathways
12.48 MAPK14 NOS2 RAC1 RAF1
35
Show member pathways
12.48 MAPK14 RAF1 TLR2 TLR4 YWHAB
36
Show member pathways
12.48 CRP IFNG IL1B IL6 TNF
37
Show member pathways
12.47 CD79A MAPK14 RAC1 RAF1
38
Show member pathways
12.42 MAPK14 RAC1 RAF1 YWHAB
39
Show member pathways
12.42 CXCL8 IFNG IL10 IL1B IL6 TNF
40
Show member pathways
12.42 IFNG IL10 IL1B MAPK14 NOS2 TLR2
41
Show member pathways
12.41 CXCL8 IL6 TLR2 TLR4 TNF
42
Show member pathways
12.41 CXCL8 IL1B MAPK14 RAC1 RAF1 TLR2
43
Show member pathways
12.41 CASP1 IL10 IL1B IL6 MAPK14 RAF1
44
Show member pathways
12.4 IFNG IL6 MAPK14 RAC1
45
Show member pathways
12.4 CXCL8 IFNG IL1B IL6 MAPK14 NOS2
46 12.39 IFNG IL6 NOS2 TLR2 TLR4 TNF
47 12.38 CXCL8 HSPD1 IL10 IL1B IL6 TNF
48
Show member pathways
12.38 CXCL8 IL1B IL6 MAPK14 NOS2 RAF1
49
Show member pathways
12.37 CASP1 IFNG IL1B TLR4 TNF
50 12.36 HSPD1 IFNG IL10 IL1B IL6 MAPK14

GO Terms for Chlamydia

Cellular components related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 CRP CXCL8 HSPD1 IFNG IL10 IL1B
2 extracellular region GO:0005576 9.81 CRP CXCL8 IFNG IL10 IL1B IL6
3 membrane raft GO:0045121 9.13 CD79A TLR2 TNF
4 lipopolysaccharide receptor complex GO:0046696 8.62 HSPD1 TLR4

Biological processes related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.99 IL1B IL6 TLR2 TLR4 TNF
2 cellular response to interferon-gamma GO:0071346 9.98 CASP1 NOS2 TLR2 TLR4
3 defense response to Gram-positive bacterium GO:0050830 9.97 CRP IL6 TLR2 TNF
4 cytokine-mediated signaling pathway GO:0019221 9.97 CASP1 CXCL8 IL10 IL1B IL6 MCL1
5 cellular response to mechanical stimulus GO:0071260 9.95 CASP1 IL1B RAC1 TLR4
6 positive regulation of JNK cascade GO:0046330 9.92 IL1B TLR4 TNF
7 regulation of insulin secretion GO:0050796 9.92 IFNG IL1B NOS2 TNF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.91 IL6 RAF1 TNF
9 apoptotic signaling pathway GO:0097190 9.91 CASP1 TLR4 TNF
10 humoral immune response GO:0006959 9.9 IFNG IL6 TNF
11 cellular response to organic substance GO:0071310 9.89 CASP1 IL1B MAPK14
12 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.88 IL1B MCL1 TNF
13 B cell proliferation GO:0042100 9.88 CD79A HSPD1 IL10
14 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.88 HSPD1 TLR2 TLR4
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 IL1B TLR2 TLR4 TNF
16 negative regulation of interleukin-6 production GO:0032715 9.87 IL10 TLR4 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.86 HSPD1 IL1B TLR4 TNF
18 negative regulation of neurogenesis GO:0050768 9.85 IL1B IL6 TNF
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IFNG IL1B TLR4 TNF
20 positive regulation of interleukin-10 production GO:0032733 9.84 HSPD1 TLR2 TLR4
21 positive regulation of interleukin-8 production GO:0032757 9.83 IL1B TLR2 TLR4 TNF
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 IL1B MAPK14 TLR2 TLR4 TNF
23 positive regulation of inflammatory response GO:0050729 9.82 TLR2 TLR4 TNF
24 positive regulation of glial cell proliferation GO:0060252 9.81 IL1B IL6 TNF
25 positive regulation of macrophage activation GO:0043032 9.81 HSPD1 IL10 TLR4
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.8 IFNG IL1B TNF
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 IL10 IL1B TNF
28 response to hypoxia GO:0001666 9.78 NOS2 RAF1 TLR2
29 positive regulation of chemokine production GO:0032722 9.78 IL6 TLR2 TLR4 TNF
30 response to molecule of bacterial origin GO:0002237 9.77 CXCL8 IL10 TLR2
31 cellular response to lipoteichoic acid GO:0071223 9.75 MAPK14 TLR2 TLR4
32 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TLR4 TNF
33 death-inducing signaling complex assembly GO:0071550 9.74 RAF1 TNF
34 negative regulation of lipid storage GO:0010888 9.74 CRP IL6 TNF
35 endothelial cell apoptotic process GO:0072577 9.73 IL10 TNF
36 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF
37 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 IL10 TLR4
38 regulation of establishment of endothelial barrier GO:1903140 9.73 IL1B TNF
39 positive regulation of interleukin-6 production GO:0032755 9.73 HSPD1 IL1B IL6 TLR2 TLR4 TNF
40 negative regulation of cytokine secretion involved in immune response GO:0002740 9.72 IL10 TNF
41 positive regulation of fever generation GO:0031622 9.72 IL1B TNF
42 regulation of cytokine production involved in inflammatory response GO:1900015 9.72 MAPK14 NOS2
43 positive regulation of interleukin-12 production GO:0032735 9.72 HSPD1 IDO1 IFNG TLR2 TLR4
44 positive regulation of killing of cells of other organism GO:0051712 9.71 IFNG NOS2
45 sequestering of triglyceride GO:0030730 9.71 IL1B TNF
46 receptor biosynthetic process GO:0032800 9.71 IL10 TNF
47 positive regulation of neuroinflammatory response GO:0150078 9.71 IL1B IL6 TNF
48 response to lipopolysaccharide GO:0032496 9.7 IDO1 IL10 IL1B MAPK14 NOS2 TLR2
49 negative regulation of interleukin-23 production GO:0032707 9.69 RAC1 TLR4
50 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.69 TLR2 TLR4

Molecular functions related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 CASP1 CD79A CRP CXCL8 HSPD1 IFNG
2 enzyme binding GO:0019899 9.8 HSPD1 MAPK14 RAC1 RAF1 YWHAB
3 identical protein binding GO:0042802 9.76 CASP1 CRP NECTIN1 RAF1 TLR2 TLR4
4 protein heterodimerization activity GO:0046982 9.65 MCL1 NECTIN1 RAF1 TLR2 TLR4
5 lipopolysaccharide binding GO:0001530 9.5 HSPD1 TLR2 TLR4
6 virion binding GO:0046790 9.43 CRP NECTIN1
7 lipopolysaccharide receptor activity GO:0001875 9.37 TLR2 TLR4
8 cytokine activity GO:0005125 9.1 CXCL8 IFNG IL10 IL1B IL6 TNF

Sources for Chlamydia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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