MCID: CHL123
MIFTS: 58

Chlamydia

Categories: Infectious diseases, Reproductive diseases

Aliases & Classifications for Chlamydia

MalaCards integrated aliases for Chlamydia:

Name: Chlamydia 12 73 3 15
Chlamydial Infection 12 54 15
Chlamydia Trachomatis Infectious Disease 12 17
Chlamydia Infections 70
Chlamydial Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11263
ICD10 32 A74.9
UMLS 70 C0008149

Summaries for Chlamydia

CDC : 3 Chlamydia is a common sexually transmitted disease (STD) that can be easily cured. If left untreated, chlamydia can make it difficult for a woman to get pregnant.

MalaCards based summary : Chlamydia, also known as chlamydial infection, is related to chlamydia pneumonia and trachoma, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Chlamydia is YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta), and among its related pathways/superpathways are Innate Immune System and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. The drugs Lymecycline and Cefixime have been mentioned in the context of this disorder. Affiliated tissues include eye, cervix and endothelial, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A commensal bacterial infectious disease that is caused by Chlamydia trachomatis.

Wikipedia : 73 Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the... more...

Related Diseases for Chlamydia

Diseases related to Chlamydia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1135)
# Related Disease Score Top Affiliating Genes
1 chlamydia pneumonia 32.3 TNF TLR4 TLR2 IL6 IL4 IL1B
2 trachoma 32.3 TNF MBL2 IL6 IL4 IL10
3 pelvic inflammatory disease 32.3 TLR4 TLR2 IFNG HSPD1 CRP
4 salpingitis 31.6 TNF TLR2 IL6 HSPD1 CRP
5 reactive arthritis 31.5 TNF TLR4 TLR2 IL6 IL1B IL10
6 cervicitis 31.5 TNF TLR4 IL6 IL1B IL10 HSPD1
7 conjunctivitis 31.5 TNF TLR4 IL6 IL4 IL10 IFNG
8 syphilis 31.5 TNF IL6 IFNG CRP
9 urethritis 31.4 TNF TLR4 TLR2 IL6 IL1B IL10
10 atherosclerosis susceptibility 31.3 TNF TLR4 IL6 IL1B HSPD1 CXCL8
11 arteries, anomalies of 31.3 TNF IL6 IL1B CRP
12 pneumonia 31.2 TNF TLR4 TLR2 MBL2 IL6 IL4
13 vaginal discharge 31.2 TNF IL6 IL1B IL10 CXCL8 CRP
14 endometritis 31.2 TNF TLR4 TLR2 IL6 IL1B CXCL8
15 prostatitis 31.2 TNF IL6 IL4 IL1B IL10 CXCL8
16 pharyngitis 31.0 TNF IL6 IL1B CXCL8 CRP
17 pyuria 31.0 IL6 CXCL8 CRP
18 haemophilus influenzae 31.0 TNF TLR2 CXCL8
19 carotid stenosis 30.9 TNF IL10 CXCL8 CRP
20 keratoconjunctivitis 30.9 TNF IL6 IL4 IFNG CXCL8
21 trichomoniasis 30.9 TNF IL6 IL1B IL10 CXCL8
22 vasculitis 30.8 TNF MBL2 IL6 HSPD1 CRP
23 vaginitis 30.8 TNF TLR2 IL6 IL1B IL10 CXCL8
24 bronchitis 30.8 TNF TLR4 TLR2 IL6 IL4 IL1B
25 orchitis 30.8 TNF IL6 IL1B IL10 CRP
26 meningoencephalitis 30.8 TNF IL6 IL1B IL10 CRP
27 lymphoma, mucosa-associated lymphoid type 30.8 TLR4 TLR2 HSPD1 CXCL8
28 hypereosinophilic syndrome 30.8 IL4 IL10 IFNG CXCL8
29 genital herpes 30.7 TLR2 IL4 IL10
30 cerebrovascular disease 30.7 TNF TLR4 IL6 CRP
31 aortic aneurysm, familial abdominal, 1 30.7 TNF IL6 IL1B IL10 CXCL8 CRP
32 urethral syndrome 30.7 TNF IL6 IL1B CXCL8
33 arteriosclerosis 30.7 TLR4 IL6 IL4 IL10 IFNG HSPD1
34 human cytomegalovirus infection 30.7 MAPK14 IL6 IL1B CXCL8
35 vascular disease 30.7 TNF TLR4 NOS2 IL6 IL10 IFNG
36 vulvovaginitis 30.7 IL10 HSPD1 CXCL8
37 rhinitis 30.7 TNF IL6 IL4 IL10 IFNG CXCL8
38 bacterial vaginosis 30.7 TNF TLR4 TLR2 MBL2 IL6 IL4
39 helicobacter pylori infection 30.7 TNF IL1B IL10 CXCL8
40 ige responsiveness, atopic 30.6 IL4 IL10 IFNG
41 synovitis 30.6 TNF IL6 IL1B CXCL8 CRP
42 pericarditis 30.6 TNF IL6 IL1B IFNG CXCL8 CRP
43 placenta disease 30.6 TNF IL6 IL1B CXCL8 CRP
44 cholera 30.6 TNF IL6 IL4 IL1B IL10
45 chronic conjunctivitis 30.6 TNF IL6 IL4 IL1B IL10 CXCL8
46 spondyloarthropathy 1 30.6 TNF TLR4 IL6 HSPD1 CRP
47 pertussis 30.6 TNF TLR4 IL6 IL1B IL10 CXCL8
48 acute cervicitis 30.5 TLR2 IL10 CXCL8
49 urinary tract infection 30.5 TLR4 CRP
50 temporal arteritis 30.5 TNF IL6 IL1B IFNG CRP

Graphical network of the top 20 diseases related to Chlamydia:



Diseases related to Chlamydia

Symptoms & Phenotypes for Chlamydia

UMLS symptoms related to Chlamydia:


fever; pruritus; pelvic pain

GenomeRNAi Phenotypes related to Chlamydia according to GeneCards Suite gene sharing:

26 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 10.29 MAPK14
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 10.29 MAPK14
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 10.29 IL10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-132 10.29 IL10
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-133 10.29 YWHAB
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 10.29 YWHAB
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.29 MAPK14
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 10.29 MAPK14
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 10.29 RAF1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-161 10.29 MAPK14 RAF1 YWHAB
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.29 IL10
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 10.29 IL10
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 10.29 CRP
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 10.29 MAPK14
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 10.29 MAPK14
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 10.29 YWHAB
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 10.29 MAPK14 RAF1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-25 10.29 IL10
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 10.29 IL10
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 10.29 CRP
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 10.29 MAPK14
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 10.29 CRP
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-80 10.29 IL10
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.29 CRP
25 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.55 CXCL8 IL10 IL1B MCL1 NOS2 RAF1
26 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.55 CASP1 CXCL8 IL10 IL1B MCL1 NOS2
27 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.55 MCL1 NOS2
28 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 9.35 MAPK14 MCL1 NOS2 RAC1 RAF1

MGI Mouse Phenotypes related to Chlamydia:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.49 CASP1 CRP HSPD1 IDO1 IFNG IL10
2 hematopoietic system MP:0005397 10.49 CASP1 HSPD1 IDO1 IFNG IL10 IL1B
3 cellular MP:0005384 10.46 CASP1 HSPD1 IDO1 IFNG IL10 IL4
4 homeostasis/metabolism MP:0005376 10.45 CASP1 CRP IDO1 IFNG IL10 IL1B
5 immune system MP:0005387 10.44 CASP1 CRP IDO1 IFNG IL10 IL1B
6 growth/size/body region MP:0005378 10.39 CASP1 HSPD1 IFNG IL10 IL1B IL4
7 integument MP:0010771 10.37 CASP1 HSPD1 IFNG IL10 IL1B IL4
8 endocrine/exocrine gland MP:0005379 10.34 CASP1 IFNG IL10 IL4 IL6 MAPK14
9 mortality/aging MP:0010768 10.33 CASP1 HSPD1 IFNG IL10 IL1B IL4
10 nervous system MP:0003631 10.24 CASP1 HSPD1 IFNG IL10 IL1B IL4
11 digestive/alimentary MP:0005381 10.22 CASP1 IFNG IL10 IL4 IL6 NOS2
12 muscle MP:0005369 10.21 HSPD1 IDO1 IFNG IL10 IL6 MAPK14
13 craniofacial MP:0005382 10.18 IFNG IL10 IL1B IL4 NOS2 RAC1
14 liver/biliary system MP:0005370 10.18 IFNG IL10 IL4 IL6 MAPK14 NOS2
15 neoplasm MP:0002006 10.14 CASP1 IFNG IL10 IL1B IL6 MAPK14
16 reproductive system MP:0005389 10.07 CASP1 HSPD1 IDO1 IFNG IL10 IL4
17 renal/urinary system MP:0005367 9.97 CASP1 IDO1 IFNG IL4 IL6 MBL2
18 respiratory system MP:0005388 9.9 HSPD1 IFNG IL10 IL4 IL6 MAPK14
19 skeleton MP:0005390 9.73 IFNG IL10 IL1B IL4 IL6 MAPK14
20 vision/eye MP:0005391 9.32 IFNG IL10 IL4 IL6 MCL1 NOS2

Drugs & Therapeutics for Chlamydia

Drugs for Chlamydia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
2
Cefixime Approved, Investigational Phase 4 79350-37-1 54362 5362065
3
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5
Oxytetracycline Approved, Investigational, Vet_approved Phase 4 79-57-2 5280972 54715139
6 Antiparasitic Agents Phase 4
7 Antiprotozoal Agents Phase 4
8 Antimalarials Phase 4
9
Metronidazole Approved Phase 3 443-48-1 4173
10
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
11
silver nitrate Approved, Investigational Phase 3 7761-88-8
12
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 12560
13
Sodium citrate Approved, Investigational Phase 2, Phase 3 68-04-2
14
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
15
Citric acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
16
Aspartic acid Approved, Nutraceutical Phase 3 56-84-8 5960
17
Solithromycin Investigational Phase 3 760981-83-7
18 KRM 1648 Phase 3
19 Anti-Infective Agents, Local Phase 3
20 Gastrointestinal Agents Phase 3
21 Erythromycin Estolate Phase 3
22 Erythromycin stearate Phase 3
23 Erythromycin Ethylsuccinate Phase 3
24 Antitubercular Agents Phase 3
25 Citrate Phase 2, Phase 3
26 Anti-Retroviral Agents Phase 3
27 N-Methylaspartate Phase 3
28
L-Alanine Nutraceutical Phase 3 56-41-7 5950
29
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
30
Tetracycline Approved, Vet_approved Phase 2 60-54-8 5353990
31
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
32
Amdinocillin Investigational, Withdrawn Phase 2 32887-01-7 36273
33 Hormones Phase 2
34 Hormone Antagonists Phase 2
35 Estrogens Phase 2
36 Amdinocillin Pivoxil Phase 2
37
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
38
Levonorgestrel Approved, Investigational 797-63-7, 17489-40-6 13109
39
Methylene blue Approved, Investigational 61-73-4
40
Emtricitabine Approved, Investigational 143491-57-0 60877
41
Medroxyprogesterone acetate Approved, Investigational 71-58-9
42
sodium fluoride Approved 7681-49-4
43
Tenofovir Experimental, Investigational 147127-20-6 464205
44 Immunologic Factors
45 Pharmaceutical Solutions
46 Reverse Transcriptase Inhibitors
47 Anti-HIV Agents
48 Antiviral Agents
49 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
50 Contraceptive Agents

Interventional clinical trials:

(show top 50) (show all 129)
# Name Status NCT ID Phase Drugs
1 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Unknown status NCT03233880 Phase 4 Azithromycin 1gm
2 Randomized, Open-label, Multicenter Study of Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection Unknown status NCT03532464 Phase 4 azithromycin;doxycycline
3 Study of Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Antibiotic Treatment Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
4 A Community-level RCT of Expedited Partner Treatment for Gonorrhea and Chlamydia Completed NCT01665690 Phase 4
5 Strategies for the Control of Blinding Trachoma: Effect of Fly Spray Completed NCT00347763 Phase 4
6 A Phase 4, Randomized, Double-Blinded, Placebo-Controlled Trial of Azithromycin Versus Doxycycline for the Treatment of Rectal Chlamydia in Men Who Have Sex With Men Completed NCT03608774 Phase 4 Azithromycin;Doxycycline
7 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4 Azithromcyin;Azithromycin
8 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
9 Eliminating Trachoma With Repeat Mass Drug Treatment Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
10 Trachoma Elimination With Repeated Mass Azithromycin Treatments Completed NCT00221364 Phase 4 Mass treatment with oral azithromycin to an entire village
11 Detection and Treatment Benefit of Microorganism (Chlamydia Trachomatis, Mycoplasma Hominis, Ureaplasma Urealyticum) in Overactive Bladder Patients Completed NCT00883818 Phase 4 azithromycin, doxycycline
12 Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Amhara Region, Ethiopia Withdrawn NCT04171388 Phase 4 Azithromycin 500 mg;Placebo oral tablet 500 mg
13 Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
14 Prospective Evaluation of Rifalazil Effect On Vascular Symptoms of Intermittent Claudication and Other Endpoints in Chlamydia Seropositive Patients Unknown status NCT00251849 Phase 3 Rifalazil
15 Home Screening for Bacterial Vaginosis to Prevent STDs Completed NCT00667368 Phase 3 Metronidazole
16 An Open-Label, Randomized, Multi-Center Study to Evaluate the Efficacy and Safety of a Single Dose of Oral Solithromycin Compared to Single-Dose Intramuscular Ceftriaxone Plus Single-Dose Oral Azithromycin in the Treatment of Male and Female Patients With Uncomplicated Urogenital Gonorrhea With or Without Concomitant Chlamydia Completed NCT02210325 Phase 3 solithromycin;ceftriaxone;azithromycin
17 Randomized Clinical Trial Evaluating Treatment Failure Following Recommended Therapy (Azithromycin Versus Doxycycline) for Genital Chlamydial Infection in Males and Females in Youth Correctional Facilities Completed NCT00980148 Phase 3 Azithromycin;Doxycycline
18 Partner Notification for Chlamydia in Primary Care: Randomised Controlled Trial and Economic Evaluation Completed NCT00112255 Phase 3
19 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
20 Safety and Efficacy of WC2031 Versus Vibramycin for the Treatment of Uncomplicated Urogenital Chlamydia Trachomatis Infection: A Randomized, Double-blind, Double-dummy, Active-controlled, Multicenter Study Completed NCT01113931 Phase 3 Doxycyline Hyclate tablet;Vibramycin (doxycyline hyclate) capsule
21 Home Screening for Chlamydia Surveillance Completed NCT00177437 Phase 3
22 Phase 2B Double-blind Placebo-controlled Efficacy Trial of EVO100 (Previously Known as Amphora ® Gel) for the Prevention of Acquisition of Urogenital Chlamydia Trachomatis Infection Completed NCT03107377 Phase 2, Phase 3 EVO100;Placebo
23 Phase 3 Trial to Assess the Efficacy of Long-term (6 Months) Combination Antibiotics as a Treatment for Chlamydia-induced Reactive Arthritis Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
24 An International Multi-centre, Randomised, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of 0.5% and 2% PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3 PRO 2000/5;Placebo
25 Phase 3 Double-blind Placebo-controlled Efficacy Trial of EVO100 Vaginal Gel for the Prevention of Urogenital Chlamydia Trachomatis and Neisseria Gonorrhoeae Infection Recruiting NCT04553068 Phase 3 EVO100;Placebo
26 Randomized Controlled Trial of Cellulose Sulfate Gel and HIV in Nigeria Terminated NCT00120770 Phase 3 Cellulose Sulfate Vaginal Gel (Microbicide)
27 Treatment Failure and Associated Predictors Following Azithromycin Treatment for Urogenital Chlamydial Infection in Males in Youth Correctional Facilities Completed NCT03249935 Phase 2 Azithromycin
28 The Participant Agreement for Contact Tracing (PACT) Study: Enhancing Partner Notification Services. Completed NCT00207493 Phase 1, Phase 2
29 A Phase 2b, Randomized, Double-Blind, Active-Controlled Study to Evaluate the Safety and Efficacy of Rifalazil (25 Milligram) Compared With Azithromycin (1 Gram) for the Treatment of Uncomplicated Genital Chlamydia Trachomatis Infection in Women Completed NCT01631201 Phase 2 Rifalazil 25 milligram;Azithromycin 1 gram
30 Erythromycin Versus Amoxicillin for Treatment of Antenatal Chlamydia Trachomatis Infection: A Randomized Controlled Trial Completed NCT01946256 Phase 2 Amoxicillin;Erythromycin
31 Immunomodulatory Effects of Hormone Therapy in Postmenopausal Women With Chronic Chlamydia Pneumoniae or Cytomegalovirus Infection Completed NCT00001890 Phase 2 Estrogen therapy
32 HoMBReS: A Lay Health Advisor Approach to Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
33 A Clinico-pathological Phase II Study With Translational Elements to Investigate the Possible Infective Causes of Non-Hodgkin Lymphoma of the Ocular Adnexae With Particular Reference to Chlamydia Species and the Effects of MALT Lymphoma Treatment With Tetracycline Completed NCT01010295 Phase 2 doxycycline (tetracycline)
34 Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis Completed NCT00043264 Phase 2 Rifampin;Azithromycin
35 Mecillinam for Treatment of Genital Chlamydia Infection in Asymptomatic Men Terminated NCT02083276 Phase 2 Pivmecillinamhydrochlorid
36 A Phase I First in Human, Double-blind, Parallel, Randomised and Placebo Controlled Clinical Trial of the Safety of SSI's Adjuvanted Chlamydia Vaccine CTH522 in Healthy Women Aged 18 to 45 Years Completed NCT02787109 Phase 1
37 Optimizing Strategies to Improve STD Partner Services Completed NCT00207454 Phase 1
38 A Phase I, Double-blind, Parallel, Randomised and Placebo-controlled Trial Investigating the Safety and Immunogenicity of a Chlamydia Vaccine, CTH522, in Healthy Adults Recruiting NCT03926728 Phase 1
39 Non-Invasive Sexually Transmitted Disease Testing in Women Seeking Emergency Contraception or Urine Pregnancy Testing: Meeting the Needs of an At-Risk Population Completed NCT00978848
40 Antigen-specific Cell Mediated Immune Response to Chlamydia Trachomatis Completed NCT00970749
41 Risk Assessment of Long-Haul Truck Drivers Completed NCT00381992
42 A Validation Study of the Cepheid Xpert CT/NG for Detecting Chlamydia Trachomatis and Neisseria Gonorrhoeae in Rectal Samples Completed NCT02099760
43 Emergency Department, Rapid Assessment for Sexually Transmitted Infection Completed NCT02386514
44 Evaluation of the Cepheid Xpert CT/NG For Management of STI in the ED: Immediate V. Delayed Test Results Completed NCT01989130
45 Clinical Evaluation of the Click Sexual Health Test for the Detection of Neisseria Gonorrhoeae (NG), Trichomonas Vaginalis (TV), and Chlamydia Trachomatis (CT) in Women Completed NCT04098900
46 Pivotal Study of a Single-Use, Point-of-Care Molecular Diagnostic Device for the Detection of Neisseria Gonorrhoeae (NG), Trichomonas Vaginalis (TV), and Chlamydia Trachomatis (CT) in Women Completed NCT03852316
47 Self-Obtained Vaginal Swabs for Chlamydia and Gonorrhea Testing: Concurrence in Non-Clinical Settings vs. Clinical Settings Completed NCT01849653
48 Screening of Gonococcal and Chlamydial Infections in the Third Trimester Completed NCT03073538
49 Pay-it-forward Gonorrhea and Chlamydia Testing Among Men Who Have Sex With Men in China: a Cluster Randomized Controlled Trial Completed NCT03741725
50 The Use of Computer-Assisted Self-Interviews to Improve Adolescent and Young Adult Health Screening in the Pediatric Emergency Department Completed NCT01708317

Search NIH Clinical Center for Chlamydia

Inferred drug relations via UMLS 70 / NDF-RT 51 :


acetyl sulfisoxazole
ERYTHROMYCIN PWDR
Sulfisoxazole

Genetic Tests for Chlamydia

Anatomical Context for Chlamydia

MalaCards organs/tissues related to Chlamydia:

40
Eye, Cervix, Endothelial, T Cells, Prostate, Monocytes, Skin

Publications for Chlamydia

Articles related to Chlamydia:

(show top 50) (show all 25987)
# Title Authors PMID Year
1
Protective immunity to Chlamydia trachomatis genital infection: evidence from human studies. 61 54
20524235 2010
2
[Chlamydia pneumoniae in the etiology of the keratoconjunctivitis sicca in adult patients (a pilot study)]. 61 54
19642357 2009
3
Chlamydia trachomatis detection in a population of asymptomatic and symptomatic women: correlation with the presence of serological markers for this infection. 54 61
18623991 2008
4
Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection. 54 61
18025098 2008
5
Chlamydia trachomatis infection, Fallopian tube damage and a mannose-binding lectin codon 54 gene polymorphism. 61 54
17496053 2007
6
[Concentrational changes of mannose-binding proteins in blood plasma during noncomplicated pregnancy and in blood plasma of pregnant women with some infections]. 61 54
16575126 2006
7
Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo. 54 61
15722416 2005
8
Human antibody responses to a Chlamydia-secreted protease factor. 61 54
15557641 2004
9
Chlamydia pneumoniae as a respiratory pathogen. 54 61
11861211 2002
10
Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. 54 61
11801686 2002
11
Heat shock protein 60 specific T-cell response in chlamydial infections. 54 61
11439151 2001
12
Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma. 54 61
11491147 2001
13
Presence of Chlamydia pneumoniae in human symptomatic and asymptomatic carotid atherosclerotic plaque. 54 61
11283382 2001
14
Chlamydia trachomatis infection of epithelial cells induces the activation of caspase-1 and release of mature IL-18. 54 61
10903751 2000
15
Immunity to heat shock proteins and pregnancy outcome. 61 54
10231007 1999
16
Human mannose-binding protein inhibits infection of HeLa cells by Chlamydia trachomatis. 54 61
9529088 1998
17
Humoral immune response to membrane components of Chlamydia trachomatis and expression of human 60 kDa heat shock protein in follicular fluid of in-vitro fertilization patients. 61 54
9194641 1997
18
Potentiation of interferon-mediated inhibition of Chlamydia infection by interleukin-1 in human macrophage cultures. 61 54
7537250 1995
19
Chlamydia trachomatis antigens: role in immunity and pathogenesis. 61 54
7866655 1994
20
Continuous B-cell epitopes in Chlamydia trachomatis heat shock protein 60. 54 61
7679373 1993
21
IgA antichlamydia antibodies as a diagnostic tool for monitoring of active chlamydial infection. 54 61
1294398 1992
22
Amniotic fluid findings in women with high levels of chlamydial antibody. 54 61
2227607 1990
23
Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria. 61
33356849 2021
24
Presence of Chlamydia trachomatis DNA in the amniotic fluid in women with preterm prelabor rupture of membranes. 61
31272257 2021
25
Multiplexed analysis of circulating IgA antibodies for SARS-CoV-2 and common respiratory pathogens in COVID-19 patients. 61
33506974 2021
26
Symptomatic Emergency Department Patients Should Undergo Empirical Therapy for Gonorrhea/Chlamydia Regardless of Testing. 61
33766271 2021
27
Diagnostics for Gonorrhea and Chlamydia in the Emergency Department: Fight Smarter Not Harder. 61
33766272 2021
28
Characterization and comparison of differentially expressed genes involved in Chlamydia psittaci persistent infection in vitro and in vivo. 61
33667981 2021
29
Estimates of the Prevalence and Incidence of Chlamydia and Gonorrhea Among US Men and Women, 2018. 61
33492094 2021
30
Author Correction: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis. 61
33589805 2021
31
Inhibition of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis Infection. 61
32918951 2021
32
The Estimated Lifetime Medical Cost of Chlamydia, Gonorrhea, and Trichomoniasis in the United States, 2018. 61
33492090 2021
33
Chlamydia trachomatis glycogen synthase promotes MAPK-mediated proinflammatory cytokine production via TLR2/TLR4 in THP-1 cells. 61
33581128 2021
34
Effectiveness of Platelet-Rich Plasma in the Prevention of Chlamydia-Induced Hydrosalpinx in a Murine Model. 61
32989630 2021
35
Fluorothiazinon, a small-molecular inhibitor of T3SS, suppresses salmonella oral infection in mice. 61
33479520 2021
36
Are Swedish swingers a risk group for sexually transmitted infections? 61
33427085 2021
37
IL-21/IL-21R Signaling Aggravated Respiratory Inflammation Induced by Intracellular Bacteria through Regulation of CD4+ T Cell Subset Responses. 61
33608454 2021
38
The influence of nasal bacterial microbiome diversity on the pathogenesis and prognosis of chronic rhinosinusitis patients with polyps. 61
32960349 2021
39
Required examinations and tests before initiating contraception: Provider practices from a national cross-sectional survey. 61
33454373 2021
40
Sexual risk-taking among young Swedish men testing for STI. 61
33006520 2021
41
Sexual Network Patterns and Their Association With Genital and Anal Human Papillomavirus Infection in Adolescent and Young Men. 61
32873501 2021
42
The Estimated Direct Lifetime Medical Costs of Sexually Transmitted Infections Acquired in the United States in 2018. 61
33492093 2021
43
Pharyngeal gonorrhoea in men who have sex with men. 61
33533296 2021
44
Genital Mycoplasma, Shigellosis, Zika, Pubic Lice, and Other Sexually Transmitted Infections: Neither Gone Nor Forgotten. 61
33492101 2021
45
Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation. 61
33351532 2021
46
Prevalence threshold of screening tests in obstetrics and gynecology. 61
33711775 2021
47
Sexually Transmitted Infections Among US Women and Men: Prevalence and Incidence Estimates, 2018. 61
33492089 2021
48
The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling. 61
33794773 2021
49
The Estimated Number and Lifetime Medical Cost of HIV Infections Attributable to Sexually Transmitted Infections Acquired in the United States in 2018: A Compilation of Published Modeling Results. 61
33492098 2021
50
It's Time to Expand Chlamydia Treatment for Gay and Bisexual Men. 61
33685878 2021

Variations for Chlamydia

Expression for Chlamydia

Search GEO for disease gene expression data for Chlamydia.

Pathways for Chlamydia

Pathways related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 YWHAB TNF TLR4 TLR2 RAF1 RAC1
2
Show member pathways
13.95 YWHAB TNF TLR4 TLR2 RAF1 RAC1
3
Show member pathways
13.95 TNF RAF1 RAC1 NOS2 MAPK14 IL6
4
Show member pathways
13.93 TNF TLR4 TLR2 MBL2 MAPK14 IL6
5
Show member pathways
13.85 TNF TLR4 RAF1 RAC1 NOS2 MAPK14
6
Show member pathways
13.69 TNF RAF1 RAC1 MAPK14 IL6 IL4
7
Show member pathways
13.59 YWHAB TNF TLR4 TLR2 RAF1 RAC1
8
Show member pathways
13.58 TNF RAF1 RAC1 NOS2 MAPK14 IL6
9
Show member pathways
13.54 YWHAB TNF RAF1 NOS2 MCL1 IL6
10
Show member pathways
13.44 TNF RAC1 IL6 IL4 IL1B IL10
11
Show member pathways
13.2 YWHAB TNF RAF1 RAC1 MAPK14 IL6
12
Show member pathways
13.2 YWHAB TNF TLR4 TLR2 RAF1 RAC1
13
Show member pathways
13.16 YWHAB RAF1 RAC1 MAPK14 IL6 IL4
14
Show member pathways
13.15 TNF TLR4 TLR2 RAF1 RAC1 MAPK14
15
Show member pathways
13.07 TNF RAC1 IL6 IL4 IL1B IL10
16
Show member pathways
13.02 TNF TLR4 TLR2 RAF1 RAC1 MAPK14
17 13.01 RAF1 RAC1 NOS2 IL6 IL4 IFNG
18
Show member pathways
12.97 TNF TLR4 TLR2 RAF1 RAC1 MAPK14
19
Show member pathways
12.95 TNF TLR4 TLR2 RAF1 RAC1 MAPK14
20 12.91 TNF RAF1 RAC1 MAPK14 IL1B CASP1
21 12.9 TNF TLR2 IL6 IL1B IFNG
22
Show member pathways
12.88 TNF RAF1 RAC1 IL6 IL4
23
Show member pathways
12.85 TNF RAF1 RAC1 MAPK14 IL1B IL10
24
Show member pathways
12.82 YWHAB TNF RAF1 MCL1 CASP1
25
Show member pathways
12.82 TNF TLR4 TLR2 IL6 IL1B
26
Show member pathways
12.81 TNF RAC1 NOS2 MAPK14 IL6 IL1B
27
Show member pathways
12.81 YWHAB TNF TLR4 TLR2 RAF1 RAC1
28
Show member pathways
12.79 TNF RAF1 MAPK14 IL1B IFNG
29
Show member pathways
12.79 TNF RAF1 RAC1 IL4 IL10 IFNG
30
Show member pathways
12.79 TNF TLR4 TLR2 RAF1 MAPK14 IL6
31 12.78 TNF TLR2 IL4 IL1B IL10 IFNG
32
Show member pathways
12.77 TNF TLR4 TLR2 MCL1 MAPK14 IL6
33
Show member pathways
12.71 TNF RAF1 RAC1 MAPK14 IL4
34
Show member pathways
12.66 TNF TLR4 TLR2 MAPK14 IL6 IL1B
35
Show member pathways
12.65 TNF RAF1 RAC1 IL4 IFNG
36 12.64 TNF TLR4 RAC1 MAPK14 IL1B CXCL8
37
Show member pathways
12.62 RAF1 RAC1 NOS2 MAPK14 IL1B
38
Show member pathways
12.61 RAF1 MCL1 IL6 IL4 IL10 IFNG
39
Show member pathways
12.57 TNF TLR2 MAPK14 IL6 IL4 IL1B
40
Show member pathways
12.55 TLR4 TLR2 RAF1 RAC1 MAPK14
41
Show member pathways
12.54 TNF IL6 IL4 IL1B IFNG CRP
42 12.52 TNF TLR4 TLR2 RAF1 RAC1 MAPK14
43
Show member pathways
12.52 YWHAB TNF TLR4 TLR2 RAF1 RAC1
44
Show member pathways
12.5 RAF1 RAC1 NOS2 MAPK14 CASP1
45
Show member pathways
12.5 RAF1 RAC1 NOS2 MAPK14 CXCL8
46
Show member pathways
12.48 TNF IL6 IL4 IL1B IL10 IFNG
47 12.47 TNF TLR4 MAPK14 IL6 IL1B CXCL8
48
Show member pathways
12.46 TNF TLR2 RAF1 NOS2 MAPK14 IL6
49
Show member pathways
12.45 TNF TLR4 RAF1 RAC1 NOS2 MAPK14
50
Show member pathways
12.44 TNF IL6 IL10 CXCL8

GO Terms for Chlamydia

Cellular components related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNF MBL2 MAPK14 IL6 IL4 IL1B
2 extracellular space GO:0005615 9.32 TNF MBL2 IL6 IL4 IL1B IL10
3 lipopolysaccharide receptor complex GO:0046696 9.16 TLR4 HSPD1

Biological processes related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.39 TLR4 TLR2 RAF1 MAPK14 IL6 IL4
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.3 TNF TLR4 TLR2 RAF1 MAPK14 IL6
3 apoptotic process GO:0006915 10.23 TLR2 RAF1 MCL1 MAPK14 IL1B IFNG
4 negative regulation of apoptotic process GO:0043066 10.2 RAF1 MCL1 IL6 IL4 IL10 HSPD1
5 negative regulation of cell proliferation GO:0008285 10.17 TLR2 RAF1 IL6 IL1B IL10 CXCL8
6 MAPK cascade GO:0000165 10.11 YWHAB TNF RAF1 MAPK14 IL1B
7 defense response to bacterium GO:0042742 10.11 TNF TLR4 NOS2 MBL2 IL10
8 positive regulation of gene expression GO:0010628 10.1 TNF TLR4 TLR2 MAPK14 IL6 IL4
9 immune response GO:0006955 10.09 TNF TLR4 TLR2 IL6 IL4 IL1B
10 positive regulation of protein phosphorylation GO:0001934 10.07 TNF RAF1 RAC1 IL1B IFNG
11 response to hypoxia GO:0001666 10.04 TLR2 RAF1 NOS2 HSPD1 CASP1
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.03 TNF TLR4 TLR2 IL6 IL1B
13 activation of MAPK activity GO:0000187 10.02 TNF TLR4 MAPK14 IL1B
14 positive regulation of DNA-binding transcription factor activity GO:0051091 10.01 TNF IL6 IL1B IL10
15 cellular response to interferon-gamma GO:0071346 9.99 TLR4 TLR2 NOS2 CASP1
16 positive regulation of tumor necrosis factor production GO:0032760 9.99 TLR4 TLR2 IL6 IFNG
17 cellular response to mechanical stimulus GO:0071260 9.98 TLR4 RAC1 IL1B CASP1
18 defense response to Gram-positive bacterium GO:0050830 9.98 TNF TLR2 MBL2 IL6 CRP
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.97 TNF IL6 IL4 IFNG
20 regulation of insulin secretion GO:0050796 9.97 TNF NOS2 IL6 IL1B IFNG
21 cytokine-mediated signaling pathway GO:0019221 9.97 TNF NOS2 MCL1 IL6 IL4 IL1B
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.95 TNF TLR4 TLR2 IL1B
23 positive regulation of interleukin-8 production GO:0032757 9.95 TNF TLR4 TLR2 IL6 IL1B
24 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR4 TLR2 IL1B IFNG HSPD1
25 response to glucocorticoid GO:0051384 9.94 TNF IL6 IL10 HSPD1
26 positive regulation of interferon-gamma production GO:0032729 9.94 TNF TLR4 IL1B HSPD1
27 negative regulation of tumor necrosis factor production GO:0032720 9.93 TLR4 IL4 IL10
28 negative regulation of interleukin-6 production GO:0032715 9.93 TNF TLR4 IL10
29 apoptotic signaling pathway GO:0097190 9.93 TNF TLR4 CASP1
30 positive regulation of T cell proliferation GO:0042102 9.93 IL6 IL4 IL1B
31 positive regulation of interleukin-1 beta production GO:0032731 9.93 TNF TLR4 IL6 IFNG CASP1
32 humoral immune response GO:0006959 9.92 TNF IL6 IFNG
33 response to activity GO:0014823 9.92 IL6 IL10 HSPD1
34 positive regulation of cytokine production GO:0001819 9.92 TNF IL10 IFNG CASP1
35 positive regulation of phagocytosis GO:0050766 9.91 TNF IL1B IFNG
36 acute-phase response GO:0006953 9.91 MBL2 IL6 CRP
37 positive regulation of chemokine production GO:0032722 9.91 TNF TLR4 TLR2 IL6 IFNG
38 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.9 TNF MCL1 IL1B
39 positive regulation of nitric oxide biosynthetic process GO:0045429 9.9 TNF TLR4 IL1B IFNG
40 positive regulation of JAK-STAT cascade GO:0046427 9.89 TNF IL6 IL10
41 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.89 TLR4 TLR2 HSPD1
42 positive regulation of interleukin-10 production GO:0032733 9.89 TLR4 TLR2 IL6 IL4 HSPD1
43 negative regulation of neurogenesis GO:0050768 9.88 TNF IL6 IL1B
44 microglial cell activation GO:0001774 9.88 TNF TLR2 IL4 IFNG
45 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.87 TNF TLR4 IL6
46 positive regulation of macrophage activation GO:0043032 9.85 TLR4 IL10 HSPD1
47 positive regulation of glial cell proliferation GO:0060252 9.85 TNF IL6 IL1B
48 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 TNF TLR4 TLR2 MAPK14 IL1B
49 positive regulation of interleukin-12 production GO:0032735 9.85 TLR4 TLR2 MAPK14 IFNG IDO1 HSPD1
50 inflammatory response GO:0006954 9.85 TNF TLR4 TLR2 RAC1 NOS2 IL6

Molecular functions related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.72 YWHAB TLR2 RAF1 RAC1 HSPD1
2 enzyme binding GO:0019899 9.65 YWHAB RAF1 RAC1 MAPK14 HSPD1
3 cytokine activity GO:0005125 9.17 TNF IL6 IL4 IL1B IL10 IFNG
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2
5 lipopolysaccharide binding GO:0001530 9.13 TLR4 TLR2 HSPD1

Sources for Chlamydia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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