MCID: CHL123
MIFTS: 60

Chlamydia

Categories: Infectious diseases, Reproductive diseases

Aliases & Classifications for Chlamydia

MalaCards integrated aliases for Chlamydia:

Name: Chlamydia 12 75 3 15
Chlamydial Infection 12 55 15
Chlamydia Trachomatis Infectious Disease 12 17
Chlamydia Infections 72
Chlamydial Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11263
ICD10 33 A74.9
UMLS 72 C0008149

Summaries for Chlamydia

CDC : 3 Chlamydia is a common sexually transmitted disease (STD) that can be easily cured. If left untreated, chlamydia can make it difficult for a woman to get pregnant.

MalaCards based summary : Chlamydia, also known as chlamydial infection, is related to trachoma and reactive arthritis, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Chlamydia is YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Lymecycline and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A commensal bacterial infectious disease that is caused by Chlamydia trachomatis.

Wikipedia : 75 Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the... more...

Related Diseases for Chlamydia

Diseases related to Chlamydia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 891)
# Related Disease Score Top Affiliating Genes
1 trachoma 33.6 TNF IL10 IDO1 HSPD1
2 reactive arthritis 32.8 TNF IL10 IFNG HSPD1 CRP
3 pelvic inflammatory disease 32.5 TLR4 TLR2 HSPD1 CRP CD40LG
4 conjunctivitis 32.4 IL6 IFNG CXCL8
5 salpingitis 32.1 TNF HSPD1 CRP
6 endometritis 31.7 TNF IL6 IL1B
7 keratoconjunctivitis 31.7 TNF IFNG CXCL8
8 atherosclerosis susceptibility 31.7 TNF TLR4 IL6 CRP
9 bronchitis 31.5 TNF CXCL8 CRP
10 vaginitis 31.4 IL6 IL1B CXCL8
11 arteries, anomalies of 31.4 TNF IL6 IL1B CRP
12 pharyngitis 31.4 IL1B CXCL8 CRP
13 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.3 IL10 IFNG HSPD1
14 prostatitis 31.3 TNF IL6 IL1B IL10 CXCL8
15 uveitis 31.3 TNF IL10 IFNG
16 acute cystitis 31.1 IL6 CXCL8 CRP
17 vulvovaginitis 31.0 IL10 HSPD1 CXCL8
18 haemophilus influenzae 31.0 TNF TLR2 IL1B CXCL8
19 cytomegalovirus infection 31.0 TNF IL6 IL1B CXCL8
20 cerebrovascular disease 30.9 TNF TLR4 IL6 CRP
21 placenta disease 30.9 IL6 IL1B CXCL8
22 human immunodeficiency virus infectious disease 30.9 TNF IL6 IL10 IFNG
23 arthritis 30.9 TNF IL6 IL1B IL10 IFNG CXCL8
24 keratitis, hereditary 30.9 TLR4 TLR2 IL1B
25 arteriosclerosis 30.9 TLR4 IL6 IL10 HSPD1 CRP
26 spondyloarthropathy 30.8 TNF IL6 IL10 IFNG
27 bacterial vaginosis 30.8 TNF TLR4 TLR2 IL6 IL1B CXCL8
28 spondyloarthropathy 1 30.8 TNF TLR4 CRP
29 spondylitis 30.8 TNF IL6 CRP
30 mastitis 30.8 TLR2 IL6 CXCL8
31 temporal arteritis 30.8 TNF IL6 IFNG CRP
32 vascular disease 30.7 TNF NOS2 IL6 HSPD1 CRP
33 spondylarthropathy 30.7 TNF TLR4 TLR2
34 hepatitis a 30.7 TNF IL10 IFNG
35 poliomyelitis 30.7 TNF IL10 IFNG
36 bacterial pneumonia 30.7 TLR4 IL6 CXCL8 CRP
37 end stage renal failure 30.7 TNF IL6 CRP
38 preterm premature rupture of the membranes 30.6 IL6 IL1B CXCL8 CRP
39 exanthem 30.6 TNF IL6 CRP
40 pericarditis 30.6 TNF IL6 IL1B IFNG CRP
41 relapsing-remitting multiple sclerosis 30.6 TNF IL10 IFNG
42 newborn respiratory distress syndrome 30.6 IL6 IL1B CXCL8
43 myocarditis 30.6 TNF NOS2 IL6 CD40LG
44 pertussis 30.5 TNF TLR4 IL6 IL1B IL10
45 laryngitis 30.5 TNF IL6 IL1B
46 acute disseminated encephalomyelitis 30.5 IL1B IL10 HSPD1
47 ileitis 30.5 TNF TLR4 TLR2 IL6
48 rubella 30.5 TNF IL10 CD40LG
49 mycobacterium chelonae 30.5 TLR2 CXCL8
50 heart disease 30.5 TNF IL6 IL1B IL10 CXCL8 CRP

Graphical network of the top 20 diseases related to Chlamydia:



Diseases related to Chlamydia

Symptoms & Phenotypes for Chlamydia

UMLS symptoms related to Chlamydia:


fever, pruritus, pelvic pain

GenomeRNAi Phenotypes related to Chlamydia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 CASP1 CD40LG CXCL8 IL10 IL1B MCL1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 CASP1 CD40LG CXCL8 IL10 IL1B MCL1
3 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 9.55 MAPK14 MCL1 NOS2 RAC1 RAF1
4 Reduced mammosphere formation GR00396-S 9.5 CASP1 CD79A CXCL8 HSPD1 IDO1 RAC1

MGI Mouse Phenotypes related to Chlamydia:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.48 CASP1 CD40LG CD79A HSPD1 IDO1 IFNG
2 cardiovascular system MP:0005385 10.46 CASP1 CD40LG CRP IDO1 IFNG IL10
3 hematopoietic system MP:0005397 10.43 CASP1 CD40LG CD79A IDO1 IFNG IL10
4 immune system MP:0005387 10.42 CASP1 CD40LG CD79A CRP IDO1 IFNG
5 homeostasis/metabolism MP:0005376 10.41 CASP1 CD40LG CD79A CRP IDO1 IFNG
6 endocrine/exocrine gland MP:0005379 10.33 CASP1 CD40LG IFNG IL10 IL6 MAPK14
7 integument MP:0010771 10.32 CASP1 CD40LG IFNG IL10 IL1B IL6
8 growth/size/body region MP:0005378 10.31 HSPD1 IFNG IL10 IL1B IL6 MAPK14
9 mortality/aging MP:0010768 10.31 CASP1 CD40LG HSPD1 IFNG IL10 IL1B
10 nervous system MP:0003631 10.2 CASP1 CD40LG CD79A HSPD1 IFNG IL10
11 muscle MP:0005369 10.18 HSPD1 IDO1 IFNG IL10 IL6 MAPK14
12 digestive/alimentary MP:0005381 10.16 CASP1 IFNG IL10 IL6 NOS2 TLR2
13 liver/biliary system MP:0005370 10.16 CD79A IFNG IL10 IL6 MAPK14 NOS2
14 neoplasm MP:0002006 10.15 CASP1 CD79A IFNG IL10 IL1B IL6
15 craniofacial MP:0005382 10.11 IFNG IL10 IL1B NOS2 RAC1 RAF1
16 reproductive system MP:0005389 9.97 CASP1 CD40LG HSPD1 IDO1 IFNG IL10
17 renal/urinary system MP:0005367 9.91 CASP1 CD40LG CD79A IDO1 IFNG IL6
18 respiratory system MP:0005388 9.61 IFNG IL10 IL6 MAPK14 NOS2 RAF1
19 skeleton MP:0005390 9.36 CD40LG IFNG IL10 IL1B IL6 MAPK14

Drugs & Therapeutics for Chlamydia

Drugs for Chlamydia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 234)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
2
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
3
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
4
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
5
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Polyestradiol phosphate Approved Phase 4 28014-46-2
8
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
9
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
10
Norgestrel Approved Phase 4 6533-00-2 13109
11
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
12
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
13
Drospirenone Approved Phase 4 67392-87-4 68873
14
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
15
Desogestrel Approved Phase 4 54024-22-5 40973
16
Norelgestromin Approved, Investigational Phase 4 53016-31-2 13752005
17
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
18
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
19
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
20
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
21
Oxytetracycline Approved, Investigational, Vet_approved Phase 4 79-57-2 5280972 54715139
22
Metronidazole Approved Phase 4 443-48-1 4173
23
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
24
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
25
Sodium citrate Approved, Investigational Phase 4 68-04-2
26
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
27 Tubulin Modulators Phase 4
28 Antimitotic Agents Phase 4
29 Contraceptives, Oral Phase 4
30 Contraceptive Agents Phase 4
31 Immunologic Factors Phase 4
32 Contraceptives, Oral, Combined Phase 4
33 Nucleic Acid Synthesis Inhibitors Phase 4
34 Estrogens Phase 4
35 Estradiol 17 beta-cypionate Phase 4
36 Estradiol 3-benzoate Phase 4
37 Micronutrients Phase 4
38 Trace Elements Phase 4
39 Nutrients Phase 4
40 Antiviral Agents Phase 4
41 Clindamycin palmitate Phase 4
42 Clindamycin phosphate Phase 4
43 diuretics Phase 4
44 Norgestimate, ethinyl estradiol drug combination Phase 4
45 Mineralocorticoid Receptor Antagonists Phase 4
46 Diuretics, Potassium Sparing Phase 4
47 Natriuretic Agents Phase 4
48 Mineralocorticoids Phase 4
49 Drospirenone and ethinyl estradiol combination Phase 4
50 Anticonvulsants Phase 4

Interventional clinical trials:

(show top 50) (show all 316)
# Name Status NCT ID Phase Drugs
1 Study of Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Antibiotic Treatment Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Sanitation, Water, and Instruction in Face-washing for Trachoma Unknown status NCT02754583 Phase 4 Azithromycin;Tetracycline;Albendazole
3 A Community-level RCT of Expedited Partner Treatment for Gonorrhea and Chlamydia Completed NCT01665690 Phase 4
4 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
5 Eliminating Trachoma With Repeat Mass Drug Treatment Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
6 Trachoma Elimination With Repeated Mass Azithromycin Treatments Completed NCT00221364 Phase 4 Mass treatment with oral azithromycin to an entire village
7 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4 Azithromcyin;Azithromycin
8 Efficacy and Side-Effects of Two Dosing Regimens of Doxycycline at Surgical Abortion: A Randomized Double-Blind Trial Completed NCT00547170 Phase 4 Doxycycline pre-operatively;Doxycycline post-operatively
9 Detection and Treatment Benefit of Microorganism (Chlamydia Trachomatis, Mycoplasma Hominis, Ureaplasma Urealyticum) in Overactive Bladder Patients Completed NCT00883818 Phase 4 azithromycin, doxycycline
10 Extended Antimicrobial Treatment of Bacterial Vaginosis Combined With Human Lactobacilli to Find the Best Treatment and Minimize the Risk of Relapses Completed NCT01245322 Phase 4 lactobacilli
11 Strategies for the Control of Blinding Trachoma: Effect of Fly Spray Completed NCT00347763 Phase 4
12 Integrating Prenatal Care to Reduce HIV/STDs Among Teens: A Translational Study Completed NCT00628771 Phase 4
13 An Open Label Study to Evaluate Cycle Control With Ortho Tri-Cyclen Lo (Norgestimate/Ethinyl Estradiol) and Yaz (Drospirenone/Ethinyl Estradiol) in Healthy Sexually Active Females Completed NCT00745901 Phase 4 Norgestimate/ethinyl estradiol; Drospirenone/ethinyl estradiol
14 Women With Epilepsy: a Pilot Study of Pharmacokinetic and Pharmacodynamic Anti-epileptic Drug Effects in Levonorgestrel Intrauterine System Users Completed NCT02362373 Phase 4 levonorgestrel IUS
15 An Open-Label, Randomized, Multicenter Trial to Evaluate Continuation Rates, Side Effects and Acceptability of NuvaRing Versus OrthoEvra Completed NCT00269620 Phase 4 ethinyl estradiol/etonogestrel vaginal ring;ethinyl estradiol/norelgestromin transdermal contraceptive
16 Research to Programs for Trachoma Elimination: Antibiotic Trial Completed NCT00792922 Phase 4 Azithromycin;Azithromycin
17 Cost-effectiveness of Three Alternative Azithromycin Treatment Strategies for Trachoma Control in Tanzania Completed NCT00347607 Phase 4
18 Periodical Presumptive Treatment of Gonorrhoea in Female Sex Workers: Impact on Prevalence of the Disease in Sex Workers and Their Clients Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
19 Costs and Effects of Early Switch of Intravenous to Oral Antibiotics in Severe Community-Acquired Pneumonia: a Multicenter Randomized Trial Completed NCT00273676 Phase 4
20 Determination of the Impact of Water and Health Education on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
21 A Prospective, Double-masked, Placebo Controlled Comparison of Topical 0.15% Ganciclovir Gel (Zirgan®) Versus 0.3% Hypromellose Gel (Genteal Gel®; Placebo) for the Treatment of Adenovirus Conjunctivitis Completed NCT01533480 Phase 4 Zirgan;genteal gel
22 A Randomised Controlled Trial of Non-absorbable (Silk) Sutures Verses Absorbable (Vicryl) Sutures During the Surgical Treatment of Trachomatous Trichiasis Completed NCT00522860 Phase 4
23 Double-Blind Placebo-Controlled Clinical Effectiveness Trial of the 23-Valent Pneumococcal Vaccine Among Military Trainees At Increased Risk of Respiratory Disease Completed NCT02079701 Phase 4
24 Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life Completed NCT02258763 Phase 4 Amoxicillin-Potassium Clavulanate Combination;Placebo
25 Gender-Affirmative Medical Care to Improve HIV Treatment Cascade Among Transgender Women Completed NCT03757117 Phase 4 Feminizing hormone therapy
26 Randomized, Controlled Clinical Trial of Day-care Based and Hospitalized Management of Severe and Very Severe Pneumonia, With Severe Malnutrition, With/Without Associated Co-morbidities in Children Completed NCT00968370 Phase 4
27 A Phase 4, Randomized, Double-Blinded, Placebo-Controlled Trial of Azithromycin Versus Doxycycline for the Treatment of Rectal Chlamydia in Men Who Have Sex With Men Recruiting NCT03608774 Phase 4 Azithromycin;Doxycycline
28 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Recruiting NCT03233880 Phase 4 Azithromycin 1gm
29 Controlled, Multicenter, Randomized Parallel Group Pilot Study With 2 Treatment Arms in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis (BV) Recruiting NCT02042287 Phase 4 Metronidazole
30 The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age Recruiting NCT04047849 Phase 4 Antibiotics, oral Azithromycin and oral Amoxicillin
31 Evaluating Impact of Azithromycin Mass Drug Administrations on All-cause Mortality and Antibiotic Resistance: Morbidity Study Enrolling by invitation NCT02048007 Phase 4 Azithromycin;Placebo
32 Effectiveness of Cervical Screening in HPV Vaccinated Women - A Randomized Trial Enrolling by invitation NCT02149030 Phase 4
33 Randomized, Open-label, Multicenter Study of Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection Not yet recruiting NCT03532464 Phase 4 azithromycin;doxycycline
34 PrEP and dPEP: Doxycycline Post-exposure Prophylaxis for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV Pre-exposure Prophylaxis Not yet recruiting NCT04050540 Phase 4 Doxycycline
35 Kebele Elimination of Trachoma for Ocular Health Not yet recruiting NCT03335072 Phase 4 Azithromycin
36 Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men Not yet recruiting NCT03980223 Phase 4 Doxycycline Hyclate Delayed-Release 200 mg
37 Trachoma Elimination Study by Focused Antibiotic (TESFA): The Impact of an Enhanced Antibiotic Treatment Regimen on Trachoma in Amhara, Ethiopia Not yet recruiting NCT03523156 Phase 4 Azithromycin mass treatment;Azithromycin targeted treatment
38 Randomized Open-label Study of the Impact of Prolonged Systemic Corticosteroid Therapy on the Course and Relapse Risk of Checkpoint Inhibitor Interstitial Lung Disease (Pneumonitis) Related to the Treatment of Solid Tumors With Anti-programmed-death Type 1 Receptor or Ligand Antibodies Not yet recruiting NCT04036721 Phase 4 Prolonged glucocorticosteroid (prednisone) regimen;Short glucocorticosteroid (prednisone) regimen
39 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective, Randomised,Placebo-controlled, Double-blind Study Terminated NCT01879930 Phase 4 doxycycline;placebo
40 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
41 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4 Azithromycin
42 Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
43 Prospective Evaluation of Rifalazil Effect On Vascular Symptoms of Intermittent Claudication and Other Endpoints in Chlamydia Seropositive Patients Unknown status NCT00251849 Phase 3 Rifalazil
44 Identigene STD Test Collection Kit Validation Study Unknown status NCT01471392 Phase 3
45 Maternal Genitourinary Infections and Adverse Perinatal Outcomes in Sylhet District, Bangladesh Unknown status NCT01572532 Phase 3
46 Randomized Clinical Trial Evaluating Treatment Failure Following Recommended Therapy (Azithromycin Versus Doxycycline) for Genital Chlamydial Infection in Males and Females in Youth Correctional Facilities Completed NCT00980148 Phase 3 Azithromycin;Doxycycline
47 Clinical Trial of Eye Prophylaxis in the Newborn Completed NCT00000120 Phase 3 Erythromycin Ointment;Silver Nitrate Drops
48 Partner Notification for Chlamydia in Primary Care: Randomised Controlled Trial and Economic Evaluation Completed NCT00112255 Phase 3
49 Safety and Efficacy of WC2031 Versus Vibramycin for the Treatment of Uncomplicated Urogenital Chlamydia Trachomatis Infection: A Randomized, Double-blind, Double-dummy, Active-controlled, Multicenter Study Completed NCT01113931 Phase 3 Doxycyline Hyclate tablet;Vibramycin (doxycyline hyclate) capsule
50 Home Screening for Chlamydia Surveillance Completed NCT00177437 Phase 3

Search NIH Clinical Center for Chlamydia

Inferred drug relations via UMLS 72 / NDF-RT 51 :


acetyl sulfisoxazole
Demeclocycline
ERYTHROMYCIN PWDR
Levofloxacin
Minocycline
Sulfadiazine
Sulfisoxazole
Tetracycline

Genetic Tests for Chlamydia

Anatomical Context for Chlamydia

MalaCards organs/tissues related to Chlamydia:

41
Testes, T Cells, Heart, Prostate, Lung, Eye, Endothelial

Publications for Chlamydia

Articles related to Chlamydia:

(show top 50) (show all 24661)
# Title Authors PMID Year
1
Protective immunity to Chlamydia trachomatis genital infection: evidence from human studies. 9 38
20524235 2010
2
[Chlamydia pneumoniae in the etiology of the keratoconjunctivitis sicca in adult patients (a pilot study)]. 9 38
19642357 2009
3
Chlamydia trachomatis detection in a population of asymptomatic and symptomatic women: correlation with the presence of serological markers for this infection. 9 38
18623991 2008
4
Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection. 9 38
18025098 2008
5
Chlamydia trachomatis infection, Fallopian tube damage and a mannose-binding lectin codon 54 gene polymorphism. 9 38
17496053 2007
6
[Concentrational changes of mannose-binding proteins in blood plasma during noncomplicated pregnancy and in blood plasma of pregnant women with some infections]. 9 38
16575126 2006
7
Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo. 9 38
15722416 2005
8
Human antibody responses to a Chlamydia-secreted protease factor. 9 38
15557641 2004
9
Chlamydia pneumoniae as a respiratory pathogen. 9 38
11861211 2002
10
Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. 9 38
11801686 2002
11
Heat shock protein 60 specific T-cell response in chlamydial infections. 9 38
11439151 2001
12
Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma. 9 38
11491147 2001
13
Presence of Chlamydia pneumoniae in human symptomatic and asymptomatic carotid atherosclerotic plaque. 9 38
11283382 2001
14
Chlamydia trachomatis infection of epithelial cells induces the activation of caspase-1 and release of mature IL-18. 9 38
10903751 2000
15
Immunity to heat shock proteins and pregnancy outcome. 9 38
10231007 1999
16
Human mannose-binding protein inhibits infection of HeLa cells by Chlamydia trachomatis. 9 38
9529088 1998
17
Humoral immune response to membrane components of Chlamydia trachomatis and expression of human 60 kDa heat shock protein in follicular fluid of in-vitro fertilization patients. 9 38
9194641 1997
18
Potentiation of interferon-mediated inhibition of Chlamydia infection by interleukin-1 in human macrophage cultures. 9 38
7537250 1995
19
Chlamydia trachomatis antigens: role in immunity and pathogenesis. 9 38
7866655 1994
20
Continuous B-cell epitopes in Chlamydia trachomatis heat shock protein 60. 9 38
7679373 1993
21
IgA antichlamydia antibodies as a diagnostic tool for monitoring of active chlamydial infection. 9 38
1294398 1992
22
Amniotic fluid findings in women with high levels of chlamydial antibody. 9 38
2227607 1990
23
Epidemiology of Treponema pallidum, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and herpes simplex virus type 2 among female sex workers in the Middle East and North Africa: systematic review and meta-analytics. 38
31360448 2019
24
Cytokine-induced expression of nitric oxide synthases in Chlamydia trachomatis-infected spontaneous aborters. 38
29720007 2019
25
Assessing Patient Opinions About Electronic Messaging for Gonorrhea and Chlamydia Result Notification and Partner Services, Durham, North Carolina. 38
31181032 2019
26
Influence of a mannose-binding lectin gene polymorphism and exposure to Chlamydia trachomatis on fallopian tube obstruction in Brazilian woman. 38
31286209 2019
27
Early Colonization of the Upper Genital Tract by Chlamydia muridarum Is Associated with Enhanced Inflammation Later in Infection. 38
31285254 2019
28
Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression. 38
31402004 2019
29
Prevalence of genital and oropharyngeal chlamydia and gonorrhoea among female sex workers in Melbourne, Australia, 2015-2017: need for oropharyngeal testing. 38
31113904 2019
30
Self-Reported Extragenital Chlamydia and Gonorrhea Testing in the Past 12 Months Among Men Who Have Sex with Men in the United States-American Men's Internet Survey, 2017. 38
31415039 2019
31
High prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae and particularly Trichomonas vaginalis diagnosed using US FDA-approved Aptima molecular tests and evaluation of conventional routine diagnostic tests in Ternopil, Ukraine. 38
31225920 2019
32
Predictive factors for HIV infection among men who have sex with men and who are seeking PrEP: a secondary analysis of the PROUD trial. 38
30918121 2019
33
Sexual risk behaviors and STDs among persons who inject drugs: A national study. 38
31319117 2019
34
Differences in sexually transmitted infection risk comparing preexposure prophylaxis users and propensity score matched historical controls in a clinic setting. 38
31149948 2019
35
Establishing simultaneous nitrification and denitrification under continuous aeration for the treatment of multi-electrolytes saline wastewater. 38
31136891 2019
36
Sexually Transmitted Infections Detected During and After Incarceration Among People with Human Immunodeficiency Virus: Prevalence and Implications for Screening and Prevention. 38
31415042 2019
37
Chlamydia pneumoniae Polioencephalomyelitis and Ganglionitis in Captive Houston Toads (Anaxyrus houstonensis). 38
31221032 2019
38
Multi-locus sequence analysis reveals a novel sequence type of Chlamydia trachomatis in Saratov Region, Russia. 38
31372233 2019
39
Proceed With Caution in Generating Evidence in the "Oropharyngeal-Anorectal Chlamydia Hypothesis" in Humans. 38
31259855 2019
40
Reply to, "Proceed With Caution in Generating Evidence in the 'Oropharyngeal-Anorectal Chlamydia Hypothesis' in Humans". 38
31403518 2019
41
Prevalence of Chlamydia trachomatis infections in the Middle East and north Africa, what next? 38
31401990 2019
42
HLA-B27 spondyloarthritis and spotted fever rickettsiosis: case-based review. 38
31134290 2019
43
An update on prevalence, diagnosis, treatment and emerging issues of genital mycoplasma infection in Indian women: A narrative review. 38
31389367 2019
44
Association between rectal douching and HIV and other sexually transmitted infections among men who have sex with men: a systematic review and meta-analysis. 38
31073094 2019
45
Self-Reported History of Chlamydia or Gonorrhea Testing Among Heterosexual Women at High Risk of HIV Infection, National HIV Behavioral Surveillance, 2013. 38
31415335 2019
46
Mycoplasma genitalium, Chlamydia trachomatis, and Neisseria gonorrhoeae Detected With Aptima Assays Performed on Self-Obtained Vaginal Swabs and Urine Collected at Home and in a Clinic. 38
31415336 2019
47
Community-level Association between Clinical Trachoma and Ocular Chlamydia Infection after MASS Azithromycin Distribution in a Mesoendemic Region of Niger. 38
30957594 2019
48
Mycoplasma genitalium co-infection with Chlamydia trachomatis and Neisseria gonorrhoeae among asymptomatic patients: the silent wick for macrolide resistance spread. 38
31320599 2019
49
Draft Genome Sequence of Avian Chlamydia abortus Genotype G1 Strain 15-70d24, Isolated from Eurasian Teal in Poland. 38
31416872 2019
50
Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer. 38
31387908 2019

Variations for Chlamydia

Expression for Chlamydia

Search GEO for disease gene expression data for Chlamydia.

Pathways for Chlamydia

Pathways related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 YWHAB TNF TLR4 TLR2 RAF1 RAC1
2
Show member pathways
13.96 TNF RAF1 RAC1 NOS2 MAPK14 IL6
3
Show member pathways
13.84 TNF TLR4 RAF1 RAC1 NOS2 MAPK14
4
Show member pathways
13.67 TNF RAF1 RAC1 MAPK14 IL6 IL1B
5
Show member pathways
13.58 YWHAB TNF TLR4 TLR2 RAF1 RAC1
6
Show member pathways
13.52 YWHAB TNF RAF1 NOS2 MCL1 IL6
7
Show member pathways
13.43 TNF RAC1 IL6 IL1B IL10 CXCL8
8
Show member pathways
13.37 TNF TLR4 TLR2 RAF1 RAC1 MAPK14
9
Show member pathways
13.17 TNF TLR4 TLR2 RAC1 NOS2 MAPK14
10
Show member pathways
13.16 YWHAB TNF TLR4 TLR2 RAF1 RAC1
11
Show member pathways
13.16 YWHAB TNF TLR4 TLR2 RAF1 RAC1
12
Show member pathways
13.09 YWHAB TNF RAF1 RAC1 MAPK14 IL6
13
Show member pathways
13.06 TNF RAF1 RAC1 MAPK14 CD79A CD40LG
14
Show member pathways
13.06 TNF RAF1 RAC1 IL6 IL1B IL10
15 12.97 RAF1 RAC1 NOS2 IL6 IFNG CXCL8
16
Show member pathways
12.96 TNF TLR4 MAPK14 IL6 IL1B IFNG
17 12.91 TNF RAF1 RAC1 MAPK14 IL1B CASP1
18
Show member pathways
12.9 YWHAB TNF RAF1 MCL1 CASP1
19
Show member pathways
12.86 TNF RAF1 MCL1 MAPK14 IL1B IFNG
20
Show member pathways
12.85 TNF TLR4 TLR2 IL6 IL1B CD40LG
21
Show member pathways
12.82 TNF RAF1 RAC1 IL10 IFNG CD79A
22
Show member pathways
12.8 TNF RAC1 NOS2 MAPK14 IL6 IL1B
23 12.78 TNF TLR2 IL1B IL10 IFNG IDO1
24
Show member pathways
12.78 TNF TLR4 TLR2 MCL1 MAPK14 IL6
25
Show member pathways
12.78 YWHAB TNF TLR4 TLR2 RAF1 RAC1
26
Show member pathways
12.76 TNF RAF1 MAPK14 IL6 IL1B IL10
27
Show member pathways
12.71 TNF RAF1 RAC1 MAPK14 CD79A
28
Show member pathways
12.62 RAF1 RAC1 NOS2 MAPK14 IL1B
29
Show member pathways
12.55 TLR4 TLR2 RAF1 RAC1 MAPK14
30
Show member pathways
12.55 TNF TLR2 MAPK14 IL6 IL1B IFNG
31
Show member pathways
12.54 RAF1 MCL1 IL6 IL10 IFNG
32 12.5 TNF TLR4 TLR2 RAF1 RAC1 MAPK14
33
Show member pathways
12.49 RAF1 RAC1 NOS2 MAPK14
34
Show member pathways
12.49 RAF1 RAC1 MAPK14 CD79A
35
Show member pathways
12.49 RAF1 RAC1 NOS2 MAPK14 CXCL8
36
Show member pathways
12.49 YWHAB TLR4 TLR2 RAF1 MAPK14
37
Show member pathways
12.48 TNF IL6 IL1B IFNG CRP
38
Show member pathways
12.43 YWHAB RAF1 RAC1 MAPK14
39
Show member pathways
12.43 TNF RAF1 MAPK14 IL6 IL1B IL10
40
Show member pathways
12.42 TNF TLR4 TLR2 IL6 CXCL8
41
Show member pathways
12.42 TNF IL6 IL1B IL10 IFNG CXCL8
42
Show member pathways
12.42 TNF TLR2 RAF1 NOS2 MAPK14 IL6
43 12.41 YWHAB TNF MCL1 CD40LG CASP1
44
Show member pathways
12.41 YWHAB TLR4 TLR2 RAF1 RAC1 MAPK14
45
Show member pathways
12.4 RAC1 MAPK14 IL6 IFNG
46 12.4 YWHAB TNF IL6 IL1B IL10 HSPD1
47
Show member pathways
12.4 TNF TLR4 RAF1 RAC1 NOS2 MAPK14
48 12.39 TNF TLR4 TLR2 NOS2 IL6 IFNG
49
Show member pathways
12.38 TNF TLR4 TLR2 NOS2 IL6 IL1B
50
Show member pathways
12.37 TNF TLR4 IL1B IFNG CASP1

GO Terms for Chlamydia

Cellular components related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 TNF MAPK14 IL6 IL1B IL10 IFNG
2 membrane raft GO:0045121 9.43 TNF TLR2 CD79A
3 extracellular space GO:0005615 9.28 TNF IL6 IL1B IL10 IFNG HSPD1
4 lipopolysaccharide receptor complex GO:0046696 8.96 TLR4 HSPD1
5 intracellular GO:0005622 8.85 RAC1

Biological processes related to Chlamydia according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Name GO ID Score Top Affiliating Genes
1 cellular response to interferon-gamma GO:0071346 9.98 TLR4 TLR2 NOS2 CASP1
2 defense response to Gram-positive bacterium GO:0050830 9.97 TNF TLR2 IL6 CRP
3 cytokine-mediated signaling pathway GO:0019221 9.97 TNF NOS2 MCL1 IL6 IL1B IL10
4 cellular response to mechanical stimulus GO:0071260 9.95 TLR4 RAC1 IL1B CASP1
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 TNF TLR4 TLR2 IL6 IL1B CD40LG
6 regulation of insulin secretion GO:0050796 9.93 TNF NOS2 IL1B IFNG
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.92 TNF RAF1 IL6
8 positive regulation of JNK cascade GO:0046330 9.92 TNF TLR4 IL1B
9 B cell differentiation GO:0030183 9.92 IL10 CD79A CD40LG
10 apoptotic signaling pathway GO:0097190 9.91 TNF TLR4 CASP1
11 positive regulation of T cell proliferation GO:0042102 9.91 IL6 IL1B CD40LG
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF TLR4 TLR2 IL1B
13 humoral immune response GO:0006959 9.9 TNF IL6 IFNG
14 cellular response to organic substance GO:0071310 9.89 MAPK14 IL1B CASP1
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.88 TNF MCL1 IL1B
16 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.88 TLR4 TLR2 HSPD1
17 positive regulation of interferon-gamma production GO:0032729 9.88 TNF TLR4 IL1B HSPD1
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF TLR4 IL1B IFNG
19 negative regulation of interleukin-6 production GO:0032715 9.87 TNF TLR4 IL10
20 B cell proliferation GO:0042100 9.87 IL10 HSPD1 CD79A CD40LG
21 negative regulation of neurogenesis GO:0050768 9.85 TNF IL6 IL1B
22 positive regulation of interleukin-8 production GO:0032757 9.85 TNF TLR4 TLR2 IL1B
23 positive regulation of interleukin-10 production GO:0032733 9.84 TLR4 TLR2 HSPD1 CD40LG
24 positive regulation of inflammatory response GO:0050729 9.83 TNF TLR4 TLR2
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 TNF TLR4 TLR2 MAPK14 IL1B
26 positive regulation of macrophage activation GO:0043032 9.82 TLR4 IL10 HSPD1
27 positive regulation of glial cell proliferation GO:0060252 9.82 TNF IL6 IL1B
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.81 TNF IL1B IFNG
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 TNF IL1B IL10
30 positive regulation of chemokine production GO:0032722 9.8 TNF TLR4 TLR2 IL6
31 positive regulation of interleukin-6 production GO:0032755 9.8 TNF TLR4 TLR2 IL6 IL1B HSPD1
32 response to lipopolysaccharide GO:0032496 9.8 TLR4 TLR2 NOS2 MAPK14 IL1B IL10
33 response to hypoxia GO:0001666 9.79 TLR2 RAF1 NOS2
34 response to molecule of bacterial origin GO:0002237 9.79 TLR2 IL10 CXCL8
35 cellular response to lipoteichoic acid GO:0071223 9.77 TLR4 TLR2 MAPK14
36 negative regulation of lipid storage GO:0010888 9.77 TNF IL6 CRP
37 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TNF TLR4
38 positive regulation of chemokine biosynthetic process GO:0045080 9.74 TNF IL1B
39 endothelial cell apoptotic process GO:0072577 9.74 TNF IL10
40 death-inducing signaling complex assembly GO:0071550 9.74 TNF RAF1
41 regulation of establishment of endothelial barrier GO:1903140 9.73 TNF IL1B
42 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 TLR4 IL10
43 negative regulation of cytokine secretion involved in immune response GO:0002740 9.73 TNF IL10
44 positive regulation of neuroinflammatory response GO:0150078 9.73 TNF IL6 IL1B
45 regulation of immunoglobulin secretion GO:0051023 9.72 TNF CD40LG
46 regulation of cytokine production involved in inflammatory response GO:1900015 9.72 NOS2 MAPK14
47 positive regulation of fever generation GO:0031622 9.72 TNF IL1B
48 sequestering of triglyceride GO:0030730 9.71 TNF IL1B
49 positive regulation of killing of cells of other organism GO:0051712 9.71 NOS2 IFNG
50 receptor biosynthetic process GO:0032800 9.7 TNF IL10

Molecular functions related to Chlamydia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 YWHAB TNF TLR4 TLR2 RAF1 RAC1
2 identical protein binding GO:0042802 9.91 YWHAB TNF TLR4 TLR2 RAF1 CRP
3 enzyme binding GO:0019899 9.72 YWHAB RAF1 RAC1 MAPK14 HSPD1
4 lipopolysaccharide binding GO:0001530 9.33 TLR4 TLR2 HSPD1
5 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
6 cytokine activity GO:0005125 9.17 TNF IL6 IL1B IL10 IFNG CXCL8

Sources for Chlamydia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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