MCID: CHL147
MIFTS: 47

Chlamydia Pneumonia

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Chlamydia Pneumonia

MalaCards integrated aliases for Chlamydia Pneumonia:

Name: Chlamydia Pneumonia 12 15
Chlamydia Pneumoniae 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0040083
ICD9CM 34 483.1
ICD10 32 J16.0

Summaries for Chlamydia Pneumonia

Disease Ontology : 12 A bacterial pneumonia has material basis in Chlamydia pneumoniae.

MalaCards based summary : Chlamydia Pneumonia, also known as chlamydia pneumoniae, is related to haemophilus influenzae and human cytomegalovirus infection. An important gene associated with Chlamydia Pneumonia is OLR1 (Oxidized Low Density Lipoprotein Receptor 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Progesterone and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and bone, and related phenotypes are immune system and cardiovascular system

Wikipedia : 73 Chlamydia pneumoniae is a species of Chlamydia, an obligate intracellular bacterium that infects humans... more...

Related Diseases for Chlamydia Pneumonia

Diseases related to Chlamydia Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1012)
# Related Disease Score Top Affiliating Genes
1 haemophilus influenzae 30.8 TNF TLR2 CXCL8
2 human cytomegalovirus infection 30.7 IL6 IL1B CXCL8
3 cerebrovascular disease 30.6 TNF TLR4 IL6 CRP APOE
4 urinary tract infection 30.5 TLR4 CRP
5 coronary stenosis 30.5 TLR4 IL6 CRP APOE
6 carotid stenosis 30.4 TNF IL10 CXCL8 CRP APOE
7 mycobacterium chelonae 30.3 TLR2 CXCL8
8 aortic atherosclerosis 30.3 TLR4 IL10 APOE
9 trachoma 30.3 TNF IL6 IL4 IL10
10 keratoconjunctivitis sicca 30.3 TNF IL4 CD4
11 erythema multiforme 30.3 TNF IL6 IL4 CXCL8
12 helicobacter pylori infection 30.3 TNF IL1B IL10 CXCL8
13 periodontitis, chronic 30.2 IL6 IL1B
14 vasculitis 30.2 TNF IL6 HSPD1 CRP CCL2
15 intermittent claudication 30.2 IL6 IL10 CRP
16 pericarditis 30.2 TNF IL6 IL1B CXCL8 CRP
17 polyclonal hypergammaglobulinemia 30.1 IL6 CRP CD4
18 pyoderma 30.1 TNF IL1B CXCL8 CRP
19 cat-scratch disease 30.1 HSPD1 CRP CD4
20 pelvic inflammatory disease 30.1 TLR4 TLR2 HSPD1 CRP CCL2
21 splenic abscess 30.0 CRP CD4
22 measles 30.0 TNF TLR4 TLR2 IL6 IL1B
23 allergic asthma 30.0 TLR4 TLR2 IL4 IL10 CXCL8
24 varicose veins 30.0 TNF IL6 CXCL8
25 suppurative otitis media 30.0 TLR4 TLR2 IL1B CRP
26 vascular dementia 30.0 TNF IL6 IL1B CRP APOE
27 infective endocarditis 30.0 TNF TLR2 IL6 CRP
28 laryngitis 29.9 TNF IL6 IL1B CRP
29 homocysteinemia 29.9 CRP CCL2 APOE
30 lymphoma, mucosa-associated lymphoid type 29.9 TLR4 TLR2 HSPD1 CXCL8 CD4
31 juvenile arthritis 29.8 IL6 IL10 CXCL8 CRP
32 acute disseminated encephalomyelitis 29.8 IL1B IL10 HSPD1
33 congestive heart failure 29.8 TNF IL6 IL1B CRP
34 mycoplasma pneumoniae pneumonia 29.8 TNF TLR2 IL6 IL4 IL10 CRP
35 erythema nodosum 29.8 TNF IL6 IL1B IL10 CXCL8 CRP
36 myositis 29.8 TNF IL6 IL1B CXCL8
37 kidney disease 29.8 TNF PPARG IL6 CRP CCL2 APOE
38 spondyloarthropathy 1 29.8 TNF TLR4 IL6 HSPD1 CRP
39 rosacea 29.8 TNF TLR2 IL6 CXCL8 CRP
40 myelitis 29.8 TNF IL6 IL10 CXCL8
41 limb ischemia 29.8 TNF IL6 CCL2
42 takayasu arteritis 29.8 TNF IL6 IL10 CRP
43 disseminated intravascular coagulation 29.8 TNF IL6 IL10 CRP
44 adult respiratory distress syndrome 29.8 TNF IL6 IL1B IL10 CXCL8
45 keratoconjunctivitis 29.8 TNF IL6 IL4 CXCL8 CCL2
46 proliferative glomerulonephritis 29.7 IL6 IL4 CCL2
47 endocarditis 29.7 TNF TLR2 IL6 IL10 HSPD1 CXCL8
48 capillary leak syndrome 29.7 IL6 CXCL8 CD8A
49 synovitis 29.7 TNF IL6 IL1B CXCL8 CRP
50 peptic ulcer disease 29.7 TNF PPARG IL1B IL10 CXCL8

Graphical network of the top 20 diseases related to Chlamydia Pneumonia:



Diseases related to Chlamydia Pneumonia

Symptoms & Phenotypes for Chlamydia Pneumonia

MGI Mouse Phenotypes related to Chlamydia Pneumonia:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.28 APOE CCL2 CD4 CD8A CPN1 CRP
2 cardiovascular system MP:0005385 10.27 APOE CRP HSPD1 IL10 IL1B IL6
3 cellular MP:0005384 10.22 APOE CD4 CD8A HSPD1 IL10 IL4
4 hematopoietic system MP:0005397 10.21 APOE CD4 CD8A HSPD1 IL10 IL1B
5 integument MP:0010771 10.15 APOE CD4 CD8A HSPD1 IL10 IL1B
6 digestive/alimentary MP:0005381 10.06 APOE CD4 IL10 IL4 IL6 TLR2
7 liver/biliary system MP:0005370 9.92 APOE IL10 IL4 IL6 PPARG TLR2
8 muscle MP:0005369 9.91 APOE HSPD1 IL10 IL6 OLR1 PPARG
9 nervous system MP:0003631 9.77 APOE CD4 CD8A HSPD1 IL10 IL1B
10 neoplasm MP:0002006 9.7 IL10 IL1B IL6 PPARG TLR2 TLR4
11 respiratory system MP:0005388 9.23 APOE HSPD1 IL10 IL4 IL6 TLR2

Drugs & Therapeutics for Chlamydia Pneumonia

Drugs for Chlamydia Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
2
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
3
Azithromycin Approved Phase 2 83905-01-5 55185 447043
4 Hormones Phase 2
5 Hormone Antagonists Phase 2
6 Estrogens Phase 2
7 Anti-Bacterial Agents Phase 2
8 Antibiotics, Antitubercular Phase 2
9 Antitubercular Agents Phase 2
10 Anti-Infective Agents Phase 2
11 Immunoglobulins
12 Immunologic Factors
13 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunomodulatory Effects of Hormone Therapy in Postmenopausal Women With Chronic Chlamydia Pneumoniae or Cytomegalovirus Infection Completed NCT00001890 Phase 2 Estrogen therapy
2 Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis Completed NCT00043264 Phase 2 Rifampin;Azithromycin
3 Prevalence of Chlamydia Pneumoniae and Mycoplasma Pneumoniae in Different Forms of Obstructive Coronary Artery Disease Completed NCT00561028

Search NIH Clinical Center for Chlamydia Pneumonia

Genetic Tests for Chlamydia Pneumonia

Anatomical Context for Chlamydia Pneumonia

MalaCards organs/tissues related to Chlamydia Pneumonia:

40
Heart, Endothelial, Bone, Brain, Lung, Smooth Muscle, Skin

Publications for Chlamydia Pneumonia

Articles related to Chlamydia Pneumonia:

(show top 50) (show all 4019)
# Title Authors PMID Year
1
Multiplexed analysis of circulating IgA antibodies for SARS-CoV-2 and common respiratory pathogens in COVID-19 patients. 61
33506974 2021
2
Beneficial Immunomodulatory Effects of Fluticasone Propionate in Chlamydia pneumoniae-Infected Mice. 61
33799333 2021
3
Development and evaluation of a novel quenching probe PCR (GENECUBE) assay for rapidly detecting and distinguishing between Chlamydia pneumoniae and Chlamydia psittaci. 61
33781806 2021
4
Application of a C. trachomatis expression system to identify C. pneumoniae proteins translocated into host cells. 61
33685970 2021
5
Licensed Anti-Microbial Drugs Logical for Clinical Trials against Pathogens Currently Suspected in Alzheimer's Disease. 61
33804679 2021
6
The global prevalence of Chlamydia pneumoniae, Helicobacter pylori, Cytomegalovirus and Herpes simplex virus in patients with coronary artery disease: A systematic review and meta-analysis. 61
33166619 2021
7
Effect of coexistence of Chlamydia pneumoniae and increased epicardial fat thickness on coronary artery disease. 61
33755966 2021
8
Association between infectious burden and cerebral microbleeds: a pilot cross-sectional study. 61
33410595 2021
9
A case report of positive Charcot´s triad from a rare infectious etiology. 61
33754594 2021
10
The association of Chlamydia pneumoniae infection with atherosclerosis: Review and update of in vitro and animal studies. 61
33609645 2021
11
Chronic infection with Chlamydia pneumoniae in asthma: a type-2 low infection related phenotype. 61
33637072 2021
12
Bacterial and Viral Infection in Patients Hospitalized for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Implication for Antimicrobial Management and Clinical Outcome. 61
33353408 2021
13
Case Report: Refractory Acute Respiratory Distress Syndrome Supported by Extracorporeal Membrane Oxygenation due to Coinfection with Chlamydia pneumoniae and Leptospirosis in Reunion Island. 61
33399045 2021
14
Co-infection of chlamydia pneumoniae and mycoplasma pneumoniae with SARS-CoV-2 is associated with more severe features. 61
33482238 2021
15
Clinical and microbial spectrum of community-acquired pneumonia in children of north India. 61
33236693 2021
16
Global Prevalence of Chlamydial Infections in Reptiles: A Systematic Review and Meta-Analysis. 61
32990530 2021
17
Study of respiratory viruses and their coinfection with bacterial and fungal pathogens in acute exacerbation of chronic obstructive pulmonary diseases. 61
33402638 2021
18
Detection of periodontal microorganisms in coronary atheromatous plaque specimens of myocardial infarction patients: A systematic review and meta-analysis. 61
31983534 2021
19
A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases. 61
33569476 2021
20
Chlamydia pneumoniae and Mycoplasma pneumoniae in children with cystic fibrosis: impact on bacterial respiratory microbiota diversity. 61
33247928 2021
21
The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals. 61
33068732 2020
22
Premature CD4+ T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome. 61
33269101 2020
23
Chronic wasting associated with Chlamydia pneumoniae in three ex situ breeding facilities for tropical frogs. 61
33150542 2020
24
Co-infection of SARS-CoV-2 with Chlamydia or Mycoplasma pneumoniae: a case series and review of the literature. 61
32725598 2020
25
Low prevalence of Chlamydia pneumoniae infections during the Mycoplasma pneumoniae epidemic season: Results of nationwide surveillance in Japan. 61
32800484 2020
26
Cell-Free Synthesis of Dopamine and Serotonin in Two Steps with Purified Enzymes. 61
33107224 2020
27
[Detection of respiratory pathogens and clinical features in 225 children with acute exacerbation of bronchial asthma]. 61
33172555 2020
28
Chlamydia pneumoniae mucositis syndrome. 61
32979333 2020
29
A retrospective survey of Chlamydia pneumoniae infection rates in paediatric patients from a single centre in Wuxi, China. 61
33115294 2020
30
Co-detection of Bordetella pertussis and other respiratory organisms in children hospitalised with lower respiratory tract infection. 61
33009451 2020
31
Super-Resolution Fluorescence Microscopy Reveals Clustering Behaviour of Chlamydia pneumoniae's Major Outer Membrane Protein. 61
33092039 2020
32
"The structure of the Type III secretion system export gate with CdsO, an ATPase lever arm". 61
33048983 2020
33
Presence of bacterial DNA in thrombotic material of patients with myocardial infarction. 61
33004892 2020
34
Differential diagnosis for suspected cases of coronavirus disease 2019: a retrospective study. 61
32948121 2020
35
Microbiota in Rosacea. 61
32914214 2020
36
Frequency of Mycoplasma pneumoniae, Legionella pneumophila and Chlamydia spp. among patients with atypical pneumonia in Tehran. 61
32953125 2020
37
Combined and interaction effect of chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in Southeast China. 61
32962687 2020
38
Etiological analysis of virus, mycoplasma pneumoniae and chlamydia pneumoniae in hospitalized children with acute respiratory infections in Huzhou. 61
32738914 2020
39
Co-infections among patients with COVID-19: The need for combination therapy with non-anti-SARS-CoV-2 agents? 61
32482366 2020
40
Efficacy of delafloxacin versus moxifloxacin against atypical bacterial respiratory pathogens in adults with community-acquired bacterial pneumonia (CABP): Data from the Delafloxacin Phase 3 CABP Trial. 61
32534142 2020
41
Reactive arthritis after COVID-19 infection. 61
32763956 2020
42
Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection. 61
32462500 2020
43
Chlamydia pneumoniae Infection in Patients Hospitalised for Community-acquired Pneumonia in Southern Jordan. 61
33589185 2020
44
Chlamydia pneumoniae infection in patients hospitalised for community-acquired pneumonia in Southern Jordan. 61
33154244 2020
45
Infection and atherosclerosis: TLR-dependent pathways. 61
32002588 2020
46
Opsonophagocytosis of Chlamydia pneumoniae by Human Monocytes and Neutrophils. 61
32284372 2020
47
High frequency of Chlamydia pneumoniae and risk factors in children with acute respiratory infection. 61
31997263 2020
48
Development of a DNA microarray assay for rapid detection of fifteen bacterial pathogens in pneumonia. 61
32576241 2020
49
TLR2/CXCR4 coassociation facilitates Chlamydia pneumoniae infection-induced atherosclerosis. 61
32330088 2020
50
ERK1/2-PPARγ pathway is involved in Chlamydia pneumonia-induced human umbilical vein endothelial cell apoptosis through increased LOX-1 expression. 61
32003295 2020

Variations for Chlamydia Pneumonia

Expression for Chlamydia Pneumonia

Search GEO for disease gene expression data for Chlamydia Pneumonia.

Pathways for Chlamydia Pneumonia

Pathways related to Chlamydia Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 TNF TLR4 TLR2 OLR1 IL6 IL4
2
Show member pathways
13.74 TNF TLR4 IL6 IL4 IL1B IL10
3
Show member pathways
13.58 TNF IL6 IL4 IL1B IL10 CXCL8
4
Show member pathways
13.52 TNF TLR4 TLR2 IL6 IL4 IL1B
5
Show member pathways
13.44 TNF IL6 IL4 IL1B IL10 CXCL8
6
Show member pathways
13.39 TNF IL6 IL4 IL1B IL10 CXCL8
7
Show member pathways
13.27 TNF TLR4 TLR2 PPARG OLR1 IL6
8
Show member pathways
13.06 TNF TLR4 TLR2 IL6 IL1B CXCL8
9
Show member pathways
12.98 TNF IL6 IL4 IL1B IL10 HSPD1
10
Show member pathways
12.94 TNF TLR4 TLR2 IL6 IL1B CXCL8
11 12.84 TNF TLR2 IL6 IL1B CCL2
12
Show member pathways
12.84 TNF TLR4 TLR2 IL6 IL1B CXCL8
13
Show member pathways
12.76 TNF TLR4 TLR2 IL6 IL1B
14
Show member pathways
12.75 TNF TLR4 TLR2 IL6 IL4 IL1B
15 12.71 TNF TLR2 IL4 IL1B IL10 CD8A
16
Show member pathways
12.7 TNF IL6 IL1B IL10 CD4 CCL2
17
Show member pathways
12.65 TNF TLR4 TLR2 IL6 IL4 IL1B
18
Show member pathways
12.56 TNF TLR4 TLR2 IL6 IL1B CXCL8
19
Show member pathways
12.51 TNF IL6 IL4 IL1B CRP CCL2
20
Show member pathways
12.5 TNF TLR2 IL6 IL4 IL1B CXCL8
21 12.44 TNF TLR4 IL1B CXCL8
22
Show member pathways
12.44 TNF IL6 IL10 CXCL8 CCL2
23
Show member pathways
12.42 TNF TLR4 IL6 IL1B CXCL8
24
Show member pathways
12.41 TNF TLR4 TLR2 IL4 IL1B IL10
25 12.39 TNF TLR4 IL6 IL1B CXCL8 CCL2
26 12.39 TNF TLR4 TLR2 IL6 IL1B IL10
27
Show member pathways
12.38 TNF TLR4 TLR2 IL6 CXCL8
28
Show member pathways
12.38 TNF IL6 IL4 IL1B IL10 CXCL8
29
Show member pathways
12.34 TNF TLR2 IL6 IL1B CXCL8
30 12.33 TNF IL6 IL1B IL10 HSPD1 CXCL8
31
Show member pathways
12.33 TNF TLR4 TLR2 IL6 IL4 IL1B
32
Show member pathways
12.28 TNF IL6 IL1B IL10
33 12.26 TNF TLR4 TLR2 IL6
34 12.17 TNF IL6 IL4 IL10 CD8A CD4
35 12.12 TNF TLR4 IL6 IL4 IL1B CXCL8
36 12.09 TNF IL6 IL4 IL1B CD8A CD4
37
Show member pathways
12.08 IL4 IL1B CD8A CD4
38 12.08 TNF IL6 IL1B CCL2
39 12.08 TNF IL6 IL4 IL1B IL10 CXCL8
40 12.07 TNF IL6 IL1B CXCL8 CCL2
41 12.04 TNF TLR4 IL1B CXCL8
42
Show member pathways
12.03 TLR4 TLR2 IL6 IL4 IL1B CD4
43 11.99 TNF TLR4 TLR2 IL6 IL1B IL10
44 11.96 TNF IL4 IL1B IL10 CD8A CD4
45 11.92 TNF TLR4 IL6 IL1B IL10 CXCL8
46 11.92 TNF TLR4 TLR2 IL6 IL1B CXCL8
47
Show member pathways
11.89 TNF PPARG IL4 CXCL8
48 11.89 TNF IL6 IL1B IL10 CD8A CD4
49 11.84 IL6 IL4 CXCL8
50 11.82 TNF TLR4 TLR2 IL6 IL4 IL10

GO Terms for Chlamydia Pneumonia

Cellular components related to Chlamydia Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF OLR1 IL6 IL4 IL1B IL10
2 membrane raft GO:0045121 9.55 TNF TLR2 OLR1 HSPD1 CD4
3 extracellular space GO:0005615 9.36 TNF IL6 IL4 IL1B IL10 HSPD1
4 lipopolysaccharide receptor complex GO:0046696 9.26 TLR4 HSPD1

Biological processes related to Chlamydia Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.35 TLR4 TLR2 PPARG IL6 IL4 IL1B
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.27 TNF TLR4 TLR2 PPARG IL6 IL4
3 positive regulation of transcription, DNA-templated GO:0045893 10.15 TNF PPARG IL6 IL4 IL1B IL10
4 negative regulation of cell proliferation GO:0008285 10.14 TLR2 PPARG IL6 IL1B IL10 CXCL8
5 positive regulation of gene expression GO:0010628 10.08 TNF TLR4 TLR2 IL6 IL4 IL1B
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.05 TNF TLR4 CD4 CCL2 APOE
7 response to lipopolysaccharide GO:0032496 10.01 TLR4 TLR2 IL1B IL10 HSPD1
8 negative regulation of neuron apoptotic process GO:0043524 10 IL10 HSPD1 CCL2 APOE
9 negative regulation of inflammatory response GO:0050728 10 PPARG IL4 IL10 APOE
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 10 TNF TLR4 TLR2 IL6 IL1B
11 defense response to Gram-positive bacterium GO:0050830 9.97 TNF TLR2 IL6 CRP
12 response to organic substance GO:0010033 9.96 TNF PPARG IL10 HSPD1
13 negative regulation of tumor necrosis factor production GO:0032720 9.92 TLR4 IL4 IL10
14 regulation of insulin secretion GO:0050796 9.92 TNF IL6 IL1B
15 negative regulation of interleukin-6 production GO:0032715 9.92 TNF TLR4 IL10
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.92 TNF TLR4 TLR2 IL1B
17 positive regulation of interferon-gamma production GO:0032729 9.92 TNF TLR4 IL1B HSPD1
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL6 IL4
19 cellular response to organic cyclic compound GO:0071407 9.91 TNF IL1B CCL2
20 positive regulation of T cell proliferation GO:0042102 9.91 IL6 IL4 IL1B CD4
21 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 TNF PPARG IL6 IL1B IL10
22 humoral immune response GO:0006959 9.9 TNF IL6 CCL2
23 positive regulation of interleukin-1 beta production GO:0032731 9.9 TNF TLR4 IL6
24 response to activity GO:0014823 9.9 IL6 IL10 HSPD1
25 negative regulation of blood vessel endothelial cell migration GO:0043537 9.89 TNF PPARG APOE
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.89 TNF TLR4 IL1B
27 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.89 TNF PPARG IL10
28 positive regulation of inflammatory response GO:0050729 9.89 TNF TLR4 TLR2 IL1B HSPD1
29 positive regulation of interleukin-12 production GO:0032735 9.88 TLR4 TLR2 HSPD1
30 protein kinase B signaling GO:0043491 9.88 TNF IL1B CCL2
31 positive regulation of JAK-STAT cascade GO:0046427 9.87 TNF IL6 IL10
32 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.86 TLR4 TLR2 HSPD1
33 microglial cell activation GO:0001774 9.86 TNF TLR2 IL4
34 regulation of synapse organization GO:0050807 9.86 TNF IL10 APOE
35 T cell activation GO:0042110 9.86 IL4 HSPD1 CD8A CD4
36 negative regulation of neurogenesis GO:0050768 9.85 TNF IL6 IL1B
37 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.85 TNF TLR4 IL6
38 response to glucocorticoid GO:0051384 9.85 TNF IL6 IL10 HSPD1 CPN1
39 positive regulation of interleukin-6 production GO:0032755 9.85 TNF TLR4 TLR2 IL6 IL1B HSPD1
40 positive regulation of T cell activation GO:0050870 9.84 HSPD1 CD4 CCL2
41 positive regulation of chemokine production GO:0032722 9.84 TNF TLR4 TLR2 IL6
42 positive regulation of interleukin-8 production GO:0032757 9.83 TNF TLR4 TLR2 IL6 IL1B
43 positive regulation of macrophage activation GO:0043032 9.82 TLR4 IL10 HSPD1
44 positive regulation of glial cell proliferation GO:0060252 9.82 TNF IL6 IL1B
45 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.81 TLR4 TLR2 CCL2
46 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.81 TNF IL1B APOE
47 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 TNF IL1B IL10
48 positive regulation of interleukin-10 production GO:0032733 9.8 TLR4 TLR2 IL6 IL4 HSPD1
49 cellular response to lipopolysaccharide GO:0071222 9.8 TNF TLR4 IL6 IL1B IL10 CXCL8
50 positive regulation of neuroinflammatory response GO:0150078 9.77 TNF IL6 IL1B

Molecular functions related to Chlamydia Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 TNF TLR4 TLR2 STK32C PPARG OLR1
2 identical protein binding GO:0042802 9.92 TNF TLR4 TLR2 PPARG OLR1 CRP
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
4 cytokine activity GO:0005125 9.17 TNF IL6 IL4 IL1B IL10 CXCL8
5 lipopolysaccharide binding GO:0001530 9.13 TLR4 TLR2 HSPD1

Sources for Chlamydia Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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