MCID: CHL147
MIFTS: 41

Chlamydia Pneumonia

Categories: Respiratory diseases

Aliases & Classifications for Chlamydia Pneumonia

MalaCards integrated aliases for Chlamydia Pneumonia:

Name: Chlamydia Pneumonia 12 15
Chlamydia Pneumoniae 76

Classifications:



External Ids:

Disease Ontology 12 DOID:0040083
ICD10 33 J16.0
ICD9CM 35 483.1

Summaries for Chlamydia Pneumonia

Disease Ontology : 12 A bacterial pneumonia has material basis in Chlamydia pneumoniae.

MalaCards based summary : Chlamydia Pneumonia, also known as chlamydia pneumoniae, is related to pelvic inflammatory disease and chlamydia. An important gene associated with Chlamydia Pneumonia is CPN1 (Carboxypeptidase N Subunit 1), and among its related pathways/superpathways are Innate Immune System and Tuberculosis. The drugs Azithromycin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial, and related phenotype is immune system.

Wikipedia : 76 Chlamydophila pneumoniae is a species of Chlamydophila, an obligate intracellular bacterium that infects... more...

Related Diseases for Chlamydia Pneumonia

Diseases related to Chlamydia Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 pelvic inflammatory disease 29.5 CRP TLR1
2 chlamydia 11.3
3 pneumonia 10.7
4 arteries, anomalies of 10.6
5 coronary artery anomaly 10.6
6 asthma 10.6
7 heart disease 10.5
8 coronary heart disease 1 10.4
9 multiple sclerosis 10.4
10 ischemia 10.4
11 lung cancer 10.3
12 macular degeneration, age-related, 1 10.3
13 myocardial infarction 10.3
14 arthritis 10.3
15 vascular disease 10.2
16 reactive arthritis 10.2
17 ischemic heart disease 10.2
18 temporal arteritis 10.2
19 acute myocardial infarction 10.2
20 alzheimer disease 10.1
21 diabetes mellitus 10.1
22 hepatitis 10.1
23 dementia 10.1
24 helicobacter pylori infection 10.1
25 angina pectoris 10.1
26 lymphoma 10.1
27 meningoencephalitis 10.1
28 ornithosis 10.1
29 carotid stenosis 10.1
30 arteriosclerosis 10.1
31 cerebrovascular disease 10.1
32 vascular dementia 10.1
33 pyelitis 10.0 CPN1 CRP
34 xanthogranulomatous pyelonephritis 10.0 CPN1 CRP
35 aortic aneurysm, familial abdominal, 1 10.0
36 biliary cirrhosis, primary, 1 10.0
37 aortic valve disease 2 10.0
38 glomerulonephritis 10.0
39 primary biliary cirrhosis 10.0
40 pharyngitis 10.0
41 pseudomyxoma peritonei 10.0
42 aortic aneurysm 10.0
43 conjunctivitis 10.0
44 myocarditis 10.0
45 herpes simplex 10.0
46 allergic asthma 10.0
47 sickle cell disease 10.0
48 primary biliary cholangitis 10.0
49 cytomegalovirus infection 10.0
50 atherosclerosis susceptibility 9.9

Graphical network of the top 20 diseases related to Chlamydia Pneumonia:



Diseases related to Chlamydia Pneumonia

Symptoms & Phenotypes for Chlamydia Pneumonia

MGI Mouse Phenotypes related to Chlamydia Pneumonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.02 CFB CPN1 CRP MAP2K3 TLR1

Drugs & Therapeutics for Chlamydia Pneumonia

Drugs for Chlamydia Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
2
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
3
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
4 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
5 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
7 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
9 Erythromycin stearate Phase 4
10 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
11 Erythromycin Estolate Phase 4
12 Erythromycin Ethylsuccinate Phase 4
13
Simvastatin Approved Phase 3 79902-63-9 54454
14 Rifamycins Phase 3,Phase 2
15 KRM 1648 Phase 3,Phase 2
16 rifamycin SV Phase 3,Phase 2
17 Central Nervous System Depressants Phase 3
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
19 Anticholesteremic Agents Phase 3
20 Lipid Regulating Agents Phase 3
21 Antimetabolites Phase 3
22 Antipsychotic Agents Phase 3
23 Tranquilizing Agents Phase 3
24 Hypolipidemic Agents Phase 3
25 Psychotropic Drugs Phase 3
26
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
27
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
28
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
29
Rifabutin Approved, Investigational Phase 2 72559-06-9 6323490
30 Cytochrome P-450 CYP3A Inducers Phase 2
31 Nucleic Acid Synthesis Inhibitors Phase 2
32 Hormone Antagonists Phase 2
33 Estrogens Phase 2
34 Hormones Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
36 Antiparasitic Agents Phase 2
37 Antiprotozoal Agents Phase 2
38 Antimalarials Phase 2
39 Immunologic Factors
40 Immunoglobulins
41 Antibodies
42 Vaccines

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 AZithromycin Against pLacebo in Exacerbations of Asthma Completed NCT01444469 Phase 4 Zithromax;Placebo
3 PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients Unknown status NCT00251849 Phase 3 Rifalazil
4 The CLARICOR Trial: Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease Completed NCT00121550 Phase 3 clarithromycin
5 ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study Completed NCT00245908 Phase 3 azithromycin
6 Simvastatin Addition for Patients With Recent-onset Schizophrenia Recruiting NCT01999309 Phase 3 Simvastatin;Placebo
7 RESTORE-IT-Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients With a History of Atherosclerotic Disease Unknown status NCT00385385 Phase 2 Rifalazil
8 Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis Completed NCT00043264 Phase 2 Rifampin;Azithromycin
9 Effects of Hormone Therapy on the Immune Systems of Postmenopausal Women With Chronic Infections Completed NCT00001890 Phase 2 Estrogen therapy
10 Anti-chlamydophila Antibiotic Combination Therapy in the Treatment of Patients With Coronary Heart Disease Recruiting NCT03618108 Phase 2 Doxycycline Capsule;Azithromycin Capsule;Rifabutin Oral Capsule;Placebo oral capsule;Placebo Oral Tablet;Placebo oral capsule
11 Etiology Study of Kawasaki Disease Unknown status NCT00154596
12 Chlamydia and Mycoplasma in Coronary Artery Disease Completed NCT00561028
13 Etiology of Community Acquired Pneumonia Completed NCT00471757
14 Infection and Cardiovascular Disease Completed NCT00005547
15 Detection of Microorganisms and Antibiotic Resistance Genes Using the Curetis Unyvero LRT55 Application Completed NCT01922024
16 Detection of Enterovirus RNA in Atheromatous Lesions Completed NCT00674531 Not Applicable
17 Assessment of Pharyngeal Carriage of Microorganisms Responsible for Transmissible Acute Respiratory Infections in HAJJ Pilgrims. Recruiting NCT02868541
18 A Molecular Toolkit for the Microbial Investigation of Severe Community Acquired Pneumonia Recruiting NCT02963142
19 DiagNostic Study of Low-dose CT and multipleX PCR on Antibiotic Treatment and Outcome of Community-Acquired Pneumonia Recruiting NCT03360851 Not Applicable
20 Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD Enrolling by invitation NCT02655302 Not Applicable
21 Emission Patterns of Respiratory Pathogens Not yet recruiting NCT03491020

Search NIH Clinical Center for Chlamydia Pneumonia

Genetic Tests for Chlamydia Pneumonia

Anatomical Context for Chlamydia Pneumonia

MalaCards organs/tissues related to Chlamydia Pneumonia:

41
Lung, Heart, Endothelial, T Cells, Smooth Muscle, Monocytes, Brain

Publications for Chlamydia Pneumonia

Articles related to Chlamydia Pneumonia:

(show top 50) (show all 856)
# Title Authors Year
1
Doxycycline suppresses Chlamydia pneumoniae induced interferon-gamma responses in peripheral blood mononuclear cells in children with allergic asthma. ( 29615379 )
2018
2
Response to "Chronic cerebrospinal venous insufficiency, chlamydia and multiple sclerosis": CCSVI, Chlamydia pneumoniae and multiple sclerosis clarification. ( 30217137 )
2018
3
Tumor necrosis factor receptor superfamily members 1a and 1b contribute to exacerbation of atherosclerosis by Chlamydia pneumoniae in mice. ( 30292879 )
2018
4
The Genetic Transformation of Chlamydia pneumoniae. ( 30305318 )
2018
5
Chlamydia pneumoniae: An Etiologic Agent for Late-Onset Dementia. ( 30356749 )
2018
6
No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis. ( 30392431 )
2018
7
A retrospective seroepidemiologic survey of Chlamydia pneumoniae infection in patients in Beijing between 2008 and 2017. ( 30403740 )
2018
8
In vitro activity of Omadacycline against Chlamydia pneumoniae. ( 30509942 )
2018
9
Chlamydia pneumoniae sero-prevalence in Moroccan patients with cardiovascular diseases. ( 30541691 )
2018
10
Chlamydia pneumoniae-induced tumour necrosis factor alpha responses are lower in children with asthma compared with non-asthma. ( 29755754 )
2018
11
Identification of Chlamydia pneumoniae candidate genes that interact with human apoptotic factor caspase-9. ( 29760350 )
2018
12
Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100only/LDLR-/- Mouse Strain. ( 29770337 )
2018
13
Pivotal Pathogenic and Biomarker Role of Chlamydia Pneumoniae in Neurovascular Diseases. ( 30019645 )
2018
14
Intranasal immunization with recombinant chlamydial protease-like activity factor attenuates atherosclerotic pathology following Chlamydia pneumoniae infection in mice. ( 30051926 )
2018
15
The endogenous antiseptic N-chlorotaurine irreversibly inactivates Chlamydia pneumoniae and Chlamydia trachomatis. ( 30074473 )
2018
16
N-acetyl-cysteine increases the replication of Chlamydia pneumoniae and prolongs the clearance of the pathogen from mice. ( 29521616 )
2018
17
Chlamydia pneumoniae exploits adipocyte lipid chaperone FABP4 to facilitate fat mobilization and intracellular growth in murine adipocytes. ( 29108997 )
2018
18
Impact of capsaicin, an active component of chili pepper, on pathogenic chlamydial growth (Chlamydia trachomatis and Chlamydia pneumoniae) in immortal human epithelial HeLa cells. ( 29132924 )
2018
19
Development of a multiplex TaqMan real-time PCR assay for the detection of Chlamydia psittaci and Chlamydia pneumoniae in human clinical specimens. ( 29291900 )
2018
20
Investigation of Chlamydia pneumoniae infection in Moroccan patients suffering from cardiovascular diseases. ( 28869155 )
2018
21
Prediction of Chlamydia pneumoniae protein localization in host mitochondria and cytoplasm and possible involvements in lung cancer etiology: a computational approach. ( 30166903 )
2017
22
The Chlamydia pneumoniae Tarp Ortholog CPn0572 Stabilizes Host F-Actin by Displacement of Cofilin. ( 29376031 )
2017
23
Serological Analysis and Drug Resistance of Chlamydia pneumoniae and Mycoplasma pneumoniae in 4500 Healthy Subjects in Shenzhen, China. ( 29057257 )
2017
24
The association between serological features of chronic Chlamydia pneumoniae infection and markers of systemic inflammation and nutrition in COPD patients. ( 29069917 )
2017
25
Serological study of Bordetella Pertussis, Mycoplasma Pneumonia and Chlamydia Pneumonia in Iranian hajj pilgrims with prolonged cough illnesses: A follow-up study. ( 29229084 )
2017
26
Growth of Chlamydia pneumoniae Is Enhanced in Cells with Impaired Mitochondrial Function. ( 29259924 )
2017
27
Hyperbolic relation between beta-cell function and insulin sensitivity for type 2 diabetes mellitus, malaria, influenza, Helicobacter pylori, Chlamydia pneumoniae, and hepatitis C virus infection-induced inflammation/oxidative stress and temporary insulin resistance in Central Africans ( 29306246 )
2017
28
Iron Homeostasis in Tissues Is Affected during Persistent Chlamydia pneumoniae Infection in Mice. ( 28691023 )
2017
29
Hypothetical protein Cpn0423 triggers NOD2 activation and contributes to Chlamydia pneumoniae-mediated inflammation. ( 28693414 )
2017
30
Acquisition of Rab11 and Rab11-Fip2-A novel strategy for Chlamydia pneumoniae early survival. ( 28787457 )
2017
31
Detection of specific Chlamydia pneumoniae and cytomegalovirus antigens in human carotid atherosclerotic plaque in a Chinese population. ( 28903431 )
2017
32
Chlamydia pneumoniae inclusion membrane protein Cpn0147 interacts with host protein CREB3. ( 28957394 )
2017
33
Infections and Chlamydia pneumoniae antibodies influence the functional outcome in thrombolysed strokes. ( 28991723 )
2017
34
Chlamydia pneumoniae infection promotes vascular endothelial cell angiogenesis through an IQGAP1-related signaling pathway. ( 28377051 )
2017
35
Molecular characterisation of Chlamydia pneumoniae associated to atherosclerosis. ( 28387800 )
2017
36
In situ detection of Chlamydia pneumoniae, C. trachomatis, and cytokines among cardiovascular diseased patients from the Amazon region of Brazil. ( 28435302 )
2017
37
Mucositis Secondary to Chlamydia pneumoniae Infection: Expanding the Mycoplasma pneumoniae-Induced Rash and Mucositis Concept. ( 28568680 )
2017
38
Methods for Real-Time PCR-Based Diagnosis of Chlamydia pneumoniae, Chlamydia psittaci, and Chlamydia abortus Infections in an Opened Molecular Diagnostic Platform. ( 28600769 )
2017
39
Lack of association of Chlamydia pneumoniae with cardiovascular diseases in virologically suppressed HIV patients. ( 27819396 )
2017
40
Neonatal apnea with Chlamydia pneumoniae infection. ( 28102626 )
2017
41
High Prevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae in Children with Acute Respiratory Infections from Lima, Peru. ( 28129377 )
2017
42
Cholesterol uptake in the mouse aorta increases during Chlamydia pneumoniae infection. ( 28158541 )
2017
43
Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors. ( 27916800 )
2016
44
Role of Chlamydia pneumoniae in the pathogenesis of hypertrophy and adenoid tissue inflammation in children. ( 27935539 )
2016
45
The Association of Chlamydia pneumonia and Helicobacter pylori IgG Seropositivity With Omentin-1, Visfatin and Adiponectin Levels in Postmenopausal Women. ( 28120588 )
2016
46
Tryptophan Codon-Dependent Transcription in Chlamydia pneumoniae during Gamma Interferon-Mediated Tryptophan Limitation. ( 27400720 )
2016
47
The Chlamydia pneumoniae Adhesin Pmp21 Forms Oligomers with Adhesive Properties. ( 27551038 )
2016
48
Biophysical and Biochemical Outcomes of Chlamydia pneumoniae Infection Promotes Pro-atherogenic Matrix Microenvironment. ( 27582738 )
2016
49
Mint Flavorings from Candies Inhibit the Infectivity of Chlamydia pneumoniae. ( 30475517 )
2016
50
Genome Wide Analysis of Chlamydia pneumoniae for Candidate Vaccine Development. ( 27225643 )
2016

Variations for Chlamydia Pneumonia

Expression for Chlamydia Pneumonia

Search GEO for disease gene expression data for Chlamydia Pneumonia.

Pathways for Chlamydia Pneumonia

GO Terms for Chlamydia Pneumonia

Biological processes related to Chlamydia Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.33 CFB HLA-DPB1 TLR1
2 regulation of complement activation GO:0030449 9.26 CFB CPN1
3 innate immune response GO:0045087 9.13 CFB CRP TLR1
4 inflammatory response GO:0006954 8.8 CRP MAP2K3 TLR1

Sources for Chlamydia Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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