MCID: CHL147
MIFTS: 42

Chlamydia Pneumonia

Categories: Respiratory diseases

Aliases & Classifications for Chlamydia Pneumonia

MalaCards integrated aliases for Chlamydia Pneumonia:

Name: Chlamydia Pneumonia 12 15
Chlamydia Pneumoniae 77

Classifications:



External Ids:

Disease Ontology 12 DOID:0040083
ICD9CM 36 483.1
ICD10 34 J16.0

Summaries for Chlamydia Pneumonia

Disease Ontology : 12 A bacterial pneumonia has material basis in Chlamydia pneumoniae.

MalaCards based summary : Chlamydia Pneumonia, also known as chlamydia pneumoniae, is related to chlamydia and pneumonia. An important gene associated with Chlamydia Pneumonia is CPN1 (Carboxypeptidase N Subunit 1), and among its related pathways/superpathways are Innate Immune System and Creation of C4 and C2 activators. The drugs Clarithromycin and Erythromycin have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Chlamydophila pneumoniae is a species of Chlamydophila, an obligate intracellular bacterium that infects... more...

Related Diseases for Chlamydia Pneumonia

Diseases related to Chlamydia Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
# Related Disease Score Top Affiliating Genes
1 chlamydia 11.5
2 pneumonia 10.8
3 arteries, anomalies of 10.8
4 coronary artery anomaly 10.7
5 heart disease 10.7
6 asthma 10.7
7 coronary heart disease 1 10.7
8 multiple sclerosis 10.6
9 myocardial infarction 10.5
10 lung cancer 10.4
11 acute myocardial infarction 10.4
12 ischemia 10.4
13 pulmonary disease, chronic obstructive 10.4
14 macular degeneration, age-related, 1 10.3
15 arthritis 10.3
16 vascular disease 10.3
17 ischemic heart disease 10.3
18 otitis media 10.3
19 legionnaires' disease 10.3
20 carotid stenosis 10.3
21 alzheimer disease 10.3
22 reactive arthritis 10.3
23 aortic aneurysm, familial abdominal, 1 10.2
24 angina pectoris 10.2
25 aortic aneurysm 10.2
26 bronchitis 10.2
27 herpes simplex 10.2
28 myocarditis 10.2
29 temporal arteritis 10.2
30 helicobacter pylori infection 10.2
31 peripheral vascular disease 10.2
32 diabetes mellitus 10.2
33 hepatitis 10.2
34 thrombosis 10.2
35 meningoencephalitis 10.2
36 dementia 10.2
37 cytomegalovirus infection 10.2
38 kawasaki disease 10.1
39 glomerulonephritis 10.1
40 lymphoma 10.1
41 endocarditis 10.1
42 ornithosis 10.1
43 arteriosclerosis 10.1
44 cerebrovascular disease 10.1
45 vascular dementia 10.1
46 atherosclerosis susceptibility 10.0
47 biliary cirrhosis, primary, 1 10.0
48 hypertension, essential 10.0
49 body mass index quantitative trait locus 1 10.0
50 epilepsy, partial, with pericentral spikes 10.0

Graphical network of the top 20 diseases related to Chlamydia Pneumonia:



Diseases related to Chlamydia Pneumonia

Symptoms & Phenotypes for Chlamydia Pneumonia

GenomeRNAi Phenotypes related to Chlamydia Pneumonia according to GeneCards Suite gene sharing:

27 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.47 MAP2K3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.47 MAP2K3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.47 MAP2K3 MAP3K7
4 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.47 MAP3K7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.47 MAP3K7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.47 MAP2K3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.47 MAP2K3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.47 MAP3K7
9 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.47 MAP3K7
10 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.47 MAP2K3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.47 MAP3K7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.47 MAP3K7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.47 MAP3K7

Drugs & Therapeutics for Chlamydia Pneumonia

Drugs for Chlamydia Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
2
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 441411 12560
3
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 447043 55185
4 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
5 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
6 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Erythromycin Ethylsuccinate Phase 4
9 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
10 Erythromycin Estolate Phase 4
11 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
12 Erythromycin stearate Phase 4
13
Simvastatin Approved Phase 3 79902-63-9 54454
14 Rifamycins Phase 3,Phase 2
15 rifamycin SV Phase 3,Phase 2
16 KRM 1648 Phase 3,Phase 2
17 Central Nervous System Depressants Phase 3
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
19 Antipsychotic Agents Phase 3
20 Lipid Regulating Agents Phase 3
21 Hypolipidemic Agents Phase 3
22 Anticholesteremic Agents Phase 3
23 Psychotropic Drugs Phase 3
24 Tranquilizing Agents Phase 3
25 Antimetabolites Phase 3
26
Rifampicin Approved Phase 2 13292-46-1 5381226 5458213
27
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
28
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
29
Rifabutin Approved, Investigational Phase 2 72559-06-9 46783538 6323490
30 Cytochrome P-450 CYP3A Inducers Phase 2
31 Nucleic Acid Synthesis Inhibitors Phase 2
32 Hormones Phase 2
33 Estrogens Phase 2
34 Hormone Antagonists Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
36 Antiprotozoal Agents Phase 2
37 Antiparasitic Agents Phase 2
38 Antimalarials Phase 2
39 Immunologic Factors
40 Immunoglobulins
41 Antibodies
42 Vaccines

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 AZithromycin Against pLacebo in Exacerbations of Asthma Completed NCT01444469 Phase 4 Zithromax;Placebo
3 PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients Unknown status NCT00251849 Phase 3 Rifalazil
4 The CLARICOR Trial: Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease Completed NCT00121550 Phase 3 clarithromycin
5 ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study Completed NCT00245908 Phase 3 azithromycin
6 Simvastatin Addition for Patients With Recent-onset Schizophrenia Recruiting NCT01999309 Phase 3 Simvastatin;Placebo
7 RESTORE-IT-Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients With a History of Atherosclerotic Disease Unknown status NCT00385385 Phase 2 Rifalazil
8 Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis Completed NCT00043264 Phase 2 Rifampin;Azithromycin
9 Effects of Hormone Therapy on the Immune Systems of Postmenopausal Women With Chronic Infections Completed NCT00001890 Phase 2 Estrogen therapy
10 Anti-chlamydophila Antibiotic Combination Therapy in the Treatment of Patients With Coronary Heart Disease Recruiting NCT03618108 Phase 2 Doxycycline Capsule;Azithromycin Capsule;Rifabutin Oral Capsule;Placebo oral capsule;Placebo Oral Tablet;Placebo oral capsule
11 Etiology Study of Kawasaki Disease Unknown status NCT00154596
12 Chlamydia and Mycoplasma in Coronary Artery Disease Completed NCT00561028
13 Etiology of Community Acquired Pneumonia Completed NCT00471757
14 Infection and Cardiovascular Disease Completed NCT00005547
15 Detection of Microorganisms and Antibiotic Resistance Genes Using the Curetis Unyvero LRT55 Application Completed NCT01922024
16 Detection of Enterovirus RNA in Atheromatous Lesions Completed NCT00674531 Not Applicable
17 A Molecular Toolkit for the Microbial Investigation of Severe Community Acquired Pneumonia Completed NCT02963142
18 Assessment of Pharyngeal Carriage of Microorganisms Responsible for Transmissible Acute Respiratory Infections in HAJJ Pilgrims. Recruiting NCT02868541
19 DiagNostic Study of Low-dose CT and multipleX PCR on Antibiotic Treatment and Outcome of Community-Acquired Pneumonia Recruiting NCT03360851 Not Applicable
20 Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD Recruiting NCT02655302 Not Applicable
21 Emission Patterns of Respiratory Pathogens Not yet recruiting NCT03491020

Search NIH Clinical Center for Chlamydia Pneumonia

Genetic Tests for Chlamydia Pneumonia

Anatomical Context for Chlamydia Pneumonia

MalaCards organs/tissues related to Chlamydia Pneumonia:

42
Heart, Endothelial, Lung, Monocytes, T Cells, Smooth Muscle, Testes

Publications for Chlamydia Pneumonia

Articles related to Chlamydia Pneumonia:

(show top 50) (show all 2230)
# Title Authors Year
1
Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease. ( 30786875 )
2019
2
Chlamydia pneumoniae is present in the dental plaque of periodontitis patients and stimulates an inflammatory response in gingival epithelial cells. ( 30956972 )
2019
3
Spontaneous remission of giant cell arteritis: possible association with a preceding acute respiratory infection and seropositivity to Chlamydia pneumoniae antibodies. ( 30962664 )
2019
4
Autophagy Limits Inflammasome During Chlamydia pneumoniae Infection. ( 31031755 )
2019
5
Clinical study of chlamydia pneumoniae infection in patients with coronary heart disease. ( 31088358 )
2019
6
Chlamydia trachomatis and Chlamydia pneumoniae Interaction with the Host: Latest Advances and Future Prospective. ( 31100923 )
2019
7
In Vitro Activity of Omadacycline against Chlamydia pneumoniae. ( 30509942 )
2019
8
The association of mannose binding lectin genotype and immune response to Chlamydia pneumoniae: The Strong Heart Study. ( 30629683 )
2019
9
Outbreak of Chlamydia pneumoniae Infections and X-ray-Confirmed Pneumonia in Army Trainees at Fort Leonard Wood, Missouri, 2014. ( 30690452 )
2019
10
Round pneumonia due to Chlamydia pneumoniae in a child. ( 30701012 )
2019
11
Chlamydia pneumoniae enhances Interleukin 8 (IL-8) production with reduced azithromycin sensitivity under hypoxia. ( 30746791 )
2019
12
Tumor necrosis factor receptor superfamily members 1a and 1b contribute to exacerbation of atherosclerosis by Chlamydia pneumoniae in mice. ( 30292879 )
2019
13
No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis. ( 30392431 )
2019
14
Intranasal immunization with recombinant chlamydial protease-like activity factor attenuates atherosclerotic pathology following Chlamydia pneumoniae infection in mice. ( 30051926 )
2019
15
Doxycycline suppresses Chlamydia pneumoniae induced interferon-gamma responses in peripheral blood mononuclear cells in children with allergic asthma. ( 29615379 )
2018
16
Chlamydia pneumoniae-induced tumour necrosis factor alpha responses are lower in children with asthma compared with non-asthma. ( 29755754 )
2018
17
Chlamydia pneumoniae sero-prevalence in Moroccan patients with cardiovascular diseases. ( 30541691 )
2018
18
Low-Dose Aspirin May Prevent Trophoblast Dysfunction in Women With Chlamydia Pneumoniae Infection. ( 30572799 )
2018
19
The therapeutic role of inhibition of miR-328 on pulmonary carcinoma induced by chlamydia pneumoniae through targeting histone H2AX. ( 30614802 )
2018
20
The endogenous antiseptic N-chlorotaurine irreversibly inactivates Chlamydia pneumoniae and Chlamydia trachomatis. ( 30074473 )
2018
21
Response to "Chronic cerebrospinal venous insufficiency, chlamydia and multiple sclerosis": CCSVI, Chlamydia pneumoniae and multiple sclerosis clarification. ( 30217137 )
2018
22
The Genetic Transformation of Chlamydia pneumoniae. ( 30305318 )
2018
23
Chlamydia pneumoniae: An Etiologic Agent for Late-Onset Dementia. ( 30356749 )
2018
24
A retrospective seroepidemiologic survey of Chlamydia pneumoniae infection in patients in Beijing between 2008 and 2017. ( 30403740 )
2018
25
Identification of Chlamydia pneumoniae candidate genes that interact with human apoptotic factor caspase-9. ( 29760350 )
2018
26
Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100only/LDLR-/- Mouse Strain. ( 29770337 )
2018
27
Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. ( 29937375 )
2018
28
Pivotal Pathogenic and Biomarker Role of Chlamydia Pneumoniae in Neurovascular Diseases. ( 30019645 )
2018
29
Chlamydia pneumoniae infection promotes monocyte transendothelial migration by increasing vascular endothelial cell permeability via the tyrosine phosphorylation of VE-cadherin. ( 29462613 )
2018
30
N-acetyl-cysteine increases the replication of Chlamydia pneumoniae and prolongs the clearance of the pathogen from mice. ( 29521616 )
2018
31
Chlamydia pneumoniae exploits adipocyte lipid chaperone FABP4 to facilitate fat mobilization and intracellular growth in murine adipocytes. ( 29108997 )
2018
32
Impact of capsaicin, an active component of chili pepper, on pathogenic chlamydial growth (Chlamydia trachomatis and Chlamydia pneumoniae) in immortal human epithelial HeLa cells. ( 29132924 )
2018
33
Development of a multiplex TaqMan real-time PCR assay for the detection of Chlamydia psittaci and Chlamydia pneumoniae in human clinical specimens. ( 29291900 )
2018
34
Investigation of Chlamydia pneumoniae infection in Moroccan patients suffering from cardiovascular diseases. ( 28869155 )
2018
35
Chlamydia pneumoniae Induces Interferon Gamma Responses in Peripheral Blood Mononuclear Cells in Children with Allergic Asthma. ( 28480606 )
2017
36
Prediction of Chlamydia pneumoniae protein localization in host mitochondria and cytoplasm and possible involvements in lung cancer etiology: a computational approach. ( 30166903 )
2017
37
Serological study of Bordetella Pertussis, Mycoplasma Pneumonia and Chlamydia Pneumonia in Iranian hajj pilgrims with prolonged cough illnesses: A follow-up study. ( 29229084 )
2017
38
Growth of Chlamydia pneumoniae Is Enhanced in Cells with Impaired Mitochondrial Function. ( 29259924 )
2017
39
Hyperbolic relation between beta-cell function and insulin sensitivity for type 2 diabetes mellitus, malaria, influenza, Helicobacter pylori, Chlamydia pneumoniae, and hepatitis C virus infection-induced inflammation/oxidative stress and temporary insulin resistance in Central Africans ( 29306246 )
2017
40
The Chlamydia pneumoniae Tarp Ortholog CPn0572 Stabilizes Host F-Actin by Displacement of Cofilin. ( 29376031 )
2017
41
Detection of specific Chlamydia pneumoniae and cytomegalovirus antigens in human carotid atherosclerotic plaque in a Chinese population. ( 28903431 )
2017
42
Chlamydia pneumoniae inclusion membrane protein Cpn0147 interacts with host protein CREB3. ( 28957394 )
2017
43
Infections and Chlamydia pneumoniae antibodies influence the functional outcome in thrombolysed strokes. ( 28991723 )
2017
44
Serological Analysis and Drug Resistance of Chlamydia pneumoniae and Mycoplasma pneumoniae in 4500 Healthy Subjects in Shenzhen, China. ( 29057257 )
2017
45
The association between serological features of chronic Chlamydia pneumoniae infection and markers of systemic inflammation and nutrition in COPD patients. ( 29069917 )
2017
46
Infection-mediated asthma: etiology, mechanisms and treatment options, with focus on Chlamydia pneumoniae and macrolides. ( 28526018 )
2017
47
Mucositis Secondary to Chlamydia pneumoniae Infection: Expanding the Mycoplasma pneumoniae-Induced Rash and Mucositis Concept. ( 28568680 )
2017
48
Methods for Real-Time PCR-Based Diagnosis of Chlamydia pneumoniae, Chlamydia psittaci, and Chlamydia abortus Infections in an Opened Molecular Diagnostic Platform. ( 28600769 )
2017
49
Iron Homeostasis in Tissues Is Affected during Persistent Chlamydia pneumoniae Infection in Mice. ( 28691023 )
2017
50
Hypothetical protein Cpn0423 triggers NOD2 activation and contributes to Chlamydia pneumoniae-mediated inflammation. ( 28693414 )
2017

Variations for Chlamydia Pneumonia

Expression for Chlamydia Pneumonia

Search GEO for disease gene expression data for Chlamydia Pneumonia.

Pathways for Chlamydia Pneumonia

Pathways related to Chlamydia Pneumonia according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 CFB CRP HLA-DPB1 MAP2K3 MAP3K7
2
Show member pathways
11.71 CFB CRP
3
Show member pathways
11.65 CFB CRP
4 11.63 MAP2K3 MAP3K7
5 11.55 MAP2K3 MAP3K7
6 11.52 MAP2K3 MAP3K7
7 11.44 MAP2K3 MAP3K7
8 11.29 MAP2K3 MAP3K7
9 11.2 MAP2K3 MAP3K7
10 11.2 CFB HLA-DPB1
11
Show member pathways
11.07 HLA-DPB1 MAP2K3 MAP3K7
12 11.01 MAP2K3 MAP3K7
13 10.9 MAP2K3 MAP3K7
14 10.62 MAP2K3 MAP3K7
15 10.28 MAP2K3 MAP3K7

GO Terms for Chlamydia Pneumonia

Biological processes related to Chlamydia Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.16 HLA-DPB1 MAP3K7
2 activation of MAPK activity GO:0000187 8.96 MAP2K3 MAP3K7
3 regulation of complement activation GO:0030449 8.62 CFB CPN1

Sources for Chlamydia Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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