MCID: CHL145
MIFTS: 22

Chlorhexidine Allergy

Categories: Immune diseases

Aliases & Classifications for Chlorhexidine Allergy

MalaCards integrated aliases for Chlorhexidine Allergy:

Name: Chlorhexidine Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040026
SNOMED-CT 67 294431008
UMLS 71 C0571344

Summaries for Chlorhexidine Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger chlorhexidine.

MalaCards based summary : Chlorhexidine Allergy is related to fruit allergy and urticaria. An important gene associated with Chlorhexidine Allergy is PEDS1 (Plasmanylethanolamine Desaturase 1). The drugs Sage and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotypes are hematopoietic system and immune system

Related Diseases for Chlorhexidine Allergy

Diseases related to Chlorhexidine Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 fruit allergy 29.8 PEDS1 ENPP3
2 urticaria 10.1
3 apricot allergy 10.1 PEDS1 ENPP3
4 cephalosporin allergy 10.1 PEDS1 ENPP3
5 dermatographia 10.1 PEDS1 ENPP3
6 carbapenem allergy 10.1 POLB ENPP3
7 oxirane allergy 10.0 PEDS1 ENPP3
8 nut allergy 10.0 PEDS1 ENPP3
9 wheat allergy 10.0 PEDS1 ENPP3
10 exanthem 10.0
11 cardiac arrest 10.0
12 latex allergy 10.0
13 allergic hypersensitivity disease 10.0
14 angioedema 10.0
15 dermatitis 10.0
16 syncope 10.0
17 egg allergy 10.0 PEDS1 ENPP3
18 legume allergy 9.9 PEDS1 ENPP3
19 drug allergy 9.8 PEDS1 ENPP3
20 pollen allergy 9.7 PEDS1 ENPP3

Graphical network of the top 20 diseases related to Chlorhexidine Allergy:



Diseases related to Chlorhexidine Allergy

Symptoms & Phenotypes for Chlorhexidine Allergy

MGI Mouse Phenotypes related to Chlorhexidine Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 CNR2 ENPP3 IL17C PEDS1 PLA2G2D POLB
2 immune system MP:0005387 9.43 CNR2 ENPP3 IL17C PEDS1 PLA2G2D POLB
3 integument MP:0010771 9.02 ASPRV1 CNR2 IL17C NDUFS7 POLB

Drugs & Therapeutics for Chlorhexidine Allergy

Drugs for Chlorhexidine Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sage Approved Phase 1
2
Chlorhexidine Approved, Vet_approved Phase 1 55-56-1 9552079 2713
3 Chlorhexidine gluconate Phase 1
4 Anti-Infective Agents, Local Phase 1
5 Dermatologic Agents Phase 1
6 Disinfectants Phase 1
7 Anti-Infective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study: Safety of Chlorhexidine (CHG) Baths in Patients Less Than 2 Months of Age Active, not recruiting NCT02326467 Phase 1 Chlorhexidine gluconate
2 Effectiveness of Dry Needling on Pain and Function for the Management of Shoulder Adhesive Capsulitis: a Randomized Controlled Trial Suspended NCT03861923

Search NIH Clinical Center for Chlorhexidine Allergy

Genetic Tests for Chlorhexidine Allergy

Anatomical Context for Chlorhexidine Allergy

MalaCards organs/tissues related to Chlorhexidine Allergy:

40
Testes

Publications for Chlorhexidine Allergy

Articles related to Chlorhexidine Allergy:

(show all 28)
# Title Authors PMID Year
1
Chlorhexidine Allergy: Current Challenges and Future Prospects. 61
32210588 2020
2
Improving awareness of chlorhexidine allergy by anaesthesiologists in China. 61
31542164 2019
3
Chlorhexidine: a hidden life-threatening allergen. 61
31720240 2019
4
Chlorhexidine Allergy: Mild Allergic Reactions Can Precede Anaphylaxis in the Healthcare Setting. 61
31380516 2019
5
Health care worker sensitivity to chlorhexidine-based hand hygiene solutions: A cross-sectional survey. 61
30765146 2019
6
Chlorhexidine allergy in the perioperative setting: a narrative review. 61
30955832 2019
7
Chlorhexidine Allergy: On the Rise and Often Overlooked. 61
30874959 2019
8
Chlorhexidine allergy: raising awareness about rare but potentially life-threatening reactions. 61
30875298 2019
9
Chlorhexidine allergy in four specialist allergy centres in the United Kingdom, 2009-13: clinical features and diagnostic tests. 61
28194756 2017
10
Prevalence of delayed-type and immediate-type hypersensitivity in healthcare workers with hand eczema. 61
27352907 2016
11
Pitfalls and peculiarities in chlorhexidine allergy. 61
27130710 2016
12
Dynamics of plasma levels of specific IgE in chlorhexidine allergic patients with and without accidental re-exposure. 61
27079633 2016
13
Perioperative chlorhexidine allergy: Is it serious? 61
25948892 2015
14
Chlorhexidine allergy: sources of exposure in the health-care setting. 61
25788633 2015
15
Standardized testing with chlorhexidine in perioperative allergy--a large single-centre evaluation. 61
24957973 2014
16
Acute allergic reaction after intravenous saline injection: an unusual presentation of chlorhexidine allergy. 61
24882493 2014
17
Chlorhexidine allergy. 61
26120519 2014
18
Immediate hypersensitivity to chlorhexidine is increasingly recognised in the United Kingdom. 61
23265264 2014
19
Allergic contact dermatitis to chlorhexidine. 61
23789882 2013
20
Chlorhexidine allergy due to topical application. 61
23422617 2012
21
Severe anaphylactic reaction to chlorhexidine during total hip arthroplasty surgery. A case report. 61
21948038 2011
22
IgE-mediated chlorhexidine allergy: a new occupational hazard? 61
19325161 2009
23
IgE-mediated allergy to chlorhexidine. 61
17559915 2007
24
Rectal stump lavage: simple procedure resulting in life-threatening complication. 61
17337376 2007
25
Anaphylactic reactions due to chlorhexidine allergy. 61
11878703 2001
26
Anaphylactic reactions in anaesthetised patients - four cases of chlorhexidine allergy. 61
11736685 2001
27
Two episodes of life-threatening anaphylaxis in the same patient to a chlorhexidine-sulphadiazine-coated central venous catheter. 61
11493510 2001
28
[Two patients with chlorhexidine allergy--anaphylactic reactions and eczema]. 61
9772819 1998

Variations for Chlorhexidine Allergy

Expression for Chlorhexidine Allergy

Search GEO for disease gene expression data for Chlorhexidine Allergy.

Pathways for Chlorhexidine Allergy

GO Terms for Chlorhexidine Allergy

Biological processes related to Chlorhexidine Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 8.92 POLB PLA2G2D IL17C CNR2

Sources for Chlorhexidine Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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