MCID: CHL145
MIFTS: 23

Chlorhexidine Allergy

Categories: Immune diseases

Aliases & Classifications for Chlorhexidine Allergy

MalaCards integrated aliases for Chlorhexidine Allergy:

Name: Chlorhexidine Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040026
SNOMED-CT 67 294431008
UMLS 71 C0571344

Summaries for Chlorhexidine Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger chlorhexidine.

MalaCards based summary : Chlorhexidine Allergy is related to urticaria and amoxicillin allergy. An important gene associated with Chlorhexidine Allergy is ENPP3 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 3), and among its related pathways/superpathways is NF-kappaB Signaling. The drugs Sage and Chlorhexidine have been mentioned in the context of this disorder. Related phenotypes are hematopoietic system and immune system

Related Diseases for Chlorhexidine Allergy

Graphical network of the top 20 diseases related to Chlorhexidine Allergy:



Diseases related to Chlorhexidine Allergy

Symptoms & Phenotypes for Chlorhexidine Allergy

MGI Mouse Phenotypes related to Chlorhexidine Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 ACE CD34 CNR2 ENPP3 HSH2D IL17C
2 immune system MP:0005387 9.1 ACE CD34 CNR2 ENPP3 HSH2D IL17C

Drugs & Therapeutics for Chlorhexidine Allergy

Drugs for Chlorhexidine Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sage Approved Phase 1
2
Chlorhexidine Approved, Vet_approved Phase 1 55-56-1 9552079 2713
3 Disinfectants Phase 1
4 Anti-Infective Agents Phase 1
5 Anti-Infective Agents, Local Phase 1
6 Chlorhexidine gluconate Phase 1
7 Dermatologic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study: Safety of Chlorhexidine (CHG) Baths in Patients Less Than 2 Months of Age Active, not recruiting NCT02326467 Phase 1 Chlorhexidine gluconate

Search NIH Clinical Center for Chlorhexidine Allergy

Genetic Tests for Chlorhexidine Allergy

Anatomical Context for Chlorhexidine Allergy

Publications for Chlorhexidine Allergy

Articles related to Chlorhexidine Allergy:

(show all 31)
# Title Authors PMID Year
1
Corrigendum to 'Mast cell activation test in chlorhexidine allergy: a proof of concept' (Br J Anaesth 2020; 125: 970-5). 61
33341225 2021
2
Mast cell activation test in chlorhexidine allergy: a proof of concept. 61
32709306 2020
3
IgE-mediated chlorhexidine allergy-Cross-reactivity with other biguanide disinfectants. 61
32678912 2020
4
Chlorhexidine Allergy: Current Challenges and Future Prospects. 61
32210588 2020
5
Improving awareness of chlorhexidine allergy by anaesthesiologists in China. 61
31542164 2019
6
Chlorhexidine: a hidden life-threatening allergen. 61
31720240 2019
7
Health care worker sensitivity to chlorhexidine-based hand hygiene solutions: A cross-sectional survey. 61
30765146 2019
8
Chlorhexidine Allergy: Mild Allergic Reactions Can Precede Anaphylaxis in the Healthcare Setting. 61
31380516 2019
9
Chlorhexidine allergy in the perioperative setting: a narrative review. 61
30955832 2019
10
Chlorhexidine Allergy: On the Rise and Often Overlooked. 61
30874959 2019
11
Chlorhexidine allergy: raising awareness about rare but potentially life-threatening reactions. 61
30875298 2019
12
Chlorhexidine allergy in four specialist allergy centres in the United Kingdom, 2009-13: clinical features and diagnostic tests. 61
28194756 2017
13
Prevalence of delayed-type and immediate-type hypersensitivity in healthcare workers with hand eczema. 61
27352907 2016
14
Pitfalls and peculiarities in chlorhexidine allergy. 61
27130710 2016
15
Dynamics of plasma levels of specific IgE in chlorhexidine allergic patients with and without accidental re-exposure. 61
27079633 2016
16
Chlorhexidine allergy: sources of exposure in the health-care setting. 61
25788633 2015
17
Perioperative chlorhexidine allergy: Is it serious? 61
25948892 2015
18
Standardized testing with chlorhexidine in perioperative allergy--a large single-centre evaluation. 61
24957973 2014
19
Acute allergic reaction after intravenous saline injection: an unusual presentation of chlorhexidine allergy. 61
24882493 2014
20
Chlorhexidine allergy. 61
26120519 2014
21
Immediate hypersensitivity to chlorhexidine is increasingly recognised in the United Kingdom. 61
23265264 2014
22
Allergic contact dermatitis to chlorhexidine. 61
23789882 2013
23
Chlorhexidine allergy due to topical application. 61
23422617 2012
24
Severe anaphylactic reaction to chlorhexidine during total hip arthroplasty surgery. A case report. 61
21948038 2011
25
IgE-mediated chlorhexidine allergy: a new occupational hazard? 61
19325161 2009
26
IgE-mediated allergy to chlorhexidine. 61
17559915 2007
27
Rectal stump lavage: simple procedure resulting in life-threatening complication. 61
17337376 2007
28
Anaphylactic reactions due to chlorhexidine allergy. 61
11878703 2001
29
Anaphylactic reactions in anaesthetised patients - four cases of chlorhexidine allergy. 61
11736685 2001
30
Two episodes of life-threatening anaphylaxis in the same patient to a chlorhexidine-sulphadiazine-coated central venous catheter. 61
11493510 2001
31
[Two patients with chlorhexidine allergy--anaphylactic reactions and eczema]. 61
9772819 1998

Variations for Chlorhexidine Allergy

Expression for Chlorhexidine Allergy

Search GEO for disease gene expression data for Chlorhexidine Allergy.

Pathways for Chlorhexidine Allergy

Pathways related to Chlorhexidine Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.31 ENPP3 CD63 CD34

GO Terms for Chlorhexidine Allergy

Cellular components related to Chlorhexidine Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 IL17C ENPP3 CD63 CD34 ACE
2 lysosome GO:0005764 9.33 CD63 CD34 ACE
3 external side of plasma membrane GO:0009897 8.8 ENPP3 CD34 ACE

Biological processes related to Chlorhexidine Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.16 ENPP3 CNR2
2 cell-matrix adhesion GO:0007160 8.96 CD63 CD34
3 regulation of blood pressure GO:0008217 8.62 CD34 ACE

Sources for Chlorhexidine Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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