MCID: CHM002
MIFTS: 21

Chmp2b-Related Frontotemporal Dementia

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chmp2b-Related Frontotemporal Dementia

MalaCards integrated aliases for Chmp2b-Related Frontotemporal Dementia:

Name: Chmp2b-Related Frontotemporal Dementia 26
Dementia, Frontotemporal, Chromosome 3-Linked 41
Frontotemporal Dementia, Chromosome 3-Linked 74
Chromosome 3-Linked Frontotemporal Dementia 26
Ftd-Chmp2b 26
Ftd-3 26
Ftd3 26
Dtm1 26

Classifications:



External Ids:

UMLS 74 C1833296

Summaries for Chmp2b-Related Frontotemporal Dementia

Genetics Home Reference : 26 CHMP2B-related frontotemporal dementia is a progressive brain disorder that affects personality, behavior, and language. The symptoms of this disorder usually become noticeable in a person's fifties or sixties, and affected people survive about 3 to 21 years after the appearance of symptoms.

MalaCards based summary : Chmp2b-Related Frontotemporal Dementia, also known as dementia, frontotemporal, chromosome 3-linked, is related to frontotemporal dementia, chromosome 3-linked and dementia, and has symptoms including myoclonus, restlessness and personality changes. The drugs Natalizumab and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Chmp2b-Related Frontotemporal Dementia

Diseases in the Frontotemporal Dementia family:

Grn-Related Frontotemporal Dementia Chmp2b-Related Frontotemporal Dementia

Diseases related to Chmp2b-Related Frontotemporal Dementia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 frontotemporal dementia, chromosome 3-linked 12.1
2 dementia 10.6
3 frontotemporal dementia 10.5
4 amyotrophic lateral sclerosis 17 10.1

Symptoms & Phenotypes for Chmp2b-Related Frontotemporal Dementia

UMLS symptoms related to Chmp2b-Related Frontotemporal Dementia:


myoclonus, restlessness, personality changes, memory loss, muscle rigidity, abnormal pyramidal signs

Drugs & Therapeutics for Chmp2b-Related Frontotemporal Dementia

Drugs for Chmp2b-Related Frontotemporal Dementia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Natalizumab Approved, Investigational Phase 4 189261-10-7
2 Immunologic Factors Phase 4
3 Orange Approved Phase 3
4
Iron Approved, Experimental Phase 3,Not Applicable 7439-89-6, 15438-31-0 27284 23925
5 Trace Elements Phase 3,Not Applicable
6 Gotu Kola Phase 3
7 Nutrients Phase 3,Not Applicable
8 Iron Supplement Phase 3
9 Micronutrients Phase 3,Not Applicable
10 Hibiscus Phase 3
11 Insulin, Globin Zinc Phase 2
12 insulin Phase 2
13
leucovorin Approved Not Applicable 58-05-9 143 6006
14
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
15 Vitamin B9 Not Applicable
16 Folate Not Applicable
17 Vitamins Not Applicable
18 Vitamin B Complex Not Applicable
19 Hematinics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Natalizumab Temporary Discontinuation Study Completed NCT02775110 Phase 4
2 Hibiscus Sabdariffa and Centella Asiatica in the Treatment of Anemia by Iron Deficiency Completed NCT01414374 Phase 3 Herbal medicine;Iron
3 MSC Administration for the Management of Type 1 Diabetic Patients Unknown status NCT02893306 Phase 2
4 Study of Sleeve Gastrectomy on Iron Intestinal Absorption in Morbidly Obese Patients Completed NCT01483768 Not Applicable
5 Tolerability, Safety and Efficacy of the HAC-Coil Deep Transcranial Magnetic Stimulation in Medication Resistance Obsessive Compulsive Disorder (OCD) Subjects Recruiting NCT01343732 Not Applicable
6 Influence of Iron and Foliate Transporters on Bioavailability of These Micronutrients in the Organism Recruiting NCT03438942 Not Applicable
7 Type 1 Diabetes and Eating Disorder Diurnal Glucose Patterns Terminated NCT01390636

Search NIH Clinical Center for Chmp2b-Related Frontotemporal Dementia

Genetic Tests for Chmp2b-Related Frontotemporal Dementia

Anatomical Context for Chmp2b-Related Frontotemporal Dementia

MalaCards organs/tissues related to Chmp2b-Related Frontotemporal Dementia:

42
Brain

Publications for Chmp2b-Related Frontotemporal Dementia

Articles related to Chmp2b-Related Frontotemporal Dementia:

# Title Authors Year
1
Chromosome 3 linked frontotemporal dementia (FTD-3). ( 12451202 )
2002
2
Chromosome 3-linked frontotemporal dementia. ( 9791535 )
1998

Variations for Chmp2b-Related Frontotemporal Dementia

Expression for Chmp2b-Related Frontotemporal Dementia

Search GEO for disease gene expression data for Chmp2b-Related Frontotemporal Dementia.

Pathways for Chmp2b-Related Frontotemporal Dementia

GO Terms for Chmp2b-Related Frontotemporal Dementia

Sources for Chmp2b-Related Frontotemporal Dementia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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