MCID: CHL040
MIFTS: 29

Cholangiolocellular Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cholangiolocellular Carcinoma

MalaCards integrated aliases for Cholangiolocellular Carcinoma:

Name: Cholangiolocellular Carcinoma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:7642
NCIt 50 C41617
UMLS 72 C1516490

Summaries for Cholangiolocellular Carcinoma

MalaCards based summary : Cholangiolocellular Carcinoma is related to bile duct adenoma and cholangiocarcinoma, and has symptoms including abdominal pain and malaise. An important gene associated with Cholangiolocellular Carcinoma is ABCB1 (ATP Binding Cassette Subfamily B Member 1), and among its related pathways/superpathways are Glucose / Energy Metabolism and MicroRNAs in cancer. Affiliated tissues include liver, and related phenotype is no phenotypic analysis.

Related Diseases for Cholangiolocellular Carcinoma

Diseases related to Cholangiolocellular Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 bile duct adenoma 29.4 MUC1 EZH2 CDKN2A
2 cholangiocarcinoma 10.7
3 intrahepatic cholangiocarcinoma 10.7
4 hepatocellular carcinoma 10.6
5 liver cirrhosis 10.3
6 rare tumor 10.3
7 microsporidiosis 10.3 ABCC1 ABCB1
8 colchicine resistance 10.3 ABCC1 ABCB1
9 gastrointestinal carcinoma 10.3 MUC1 ABCB1
10 pancreatic mucinous cystadenoma 10.2 MUC1 EZH2
11 viral hepatitis 10.2
12 hemangioma 10.2
13 hemangioma of liver 10.2
14 uterine sarcoma 10.2 ABCC1 ABCB1
15 extrahepatic cholestasis 10.1 ABCC3 ABCC1
16 breast cancer 10.1
17 fibrosis of extraocular muscles, congenital, 1 10.1
18 pulmonary fibrosis, idiopathic 10.1
19 schistosoma mansoni infection, susceptibility/ 10.1
20 caroli disease, isolated 10.1
21 convulsions, familial infantile, with paroxysmal choreoathetosis 10.1
22 gastrointestinal stromal tumor 10.1
23 hepatitis c virus 10.1
24 cholangitis, primary sclerosing 10.1
25 intestinal schistosomiasis 10.1
26 caroli disease 10.1
27 adrenal cortical adenoma 10.1
28 leukemia 10.1
29 schistosomiasis 10.1
30 sclerosing cholangitis 10.1
31 idiopathic interstitial pneumonia 10.1
32 pulmonary fibrosis 10.1
33 tubular adenocarcinoma 10.1
34 adenoma 10.1
35 cholangitis 10.1
36 dubin-johnson syndrome 10.1 ABCC3 ABCC1
37 malignant peritoneal mesothelioma 9.9 MUC1 CDKN2A
38 peritoneal mesothelioma 9.9 MUC1 CDKN2A
39 endometrial mucinous adenocarcinoma 9.9 MUC1 CDKN2A
40 mucinous adenocarcinoma 9.9 MUC1 CDKN2A
41 sarcomatoid mesothelioma 9.9 MUC1 CDKN2A
42 pleomorphic liposarcoma 9.9 MUC1 CDKN2A
43 ischemic fasciitis 9.9 MUC1 CDKN2A
44 well-differentiated liposarcoma 9.9 MUC1 CDKN2A
45 mucinous bronchioloalveolar adenocarcinoma 9.9 MUC1 CDKN2A
46 meningeal melanocytoma 9.8 MUC1 CDKN2A
47 pancreatic ductal carcinoma 9.8 MUC1 CDKN2A
48 neurofibroma 9.8 MUC1 CDKN2A
49 cholecystitis 9.7 MUC1 CDKN2A
50 gastric adenosquamous carcinoma 9.7 PROM1 CDKN2A

Graphical network of the top 20 diseases related to Cholangiolocellular Carcinoma:



Diseases related to Cholangiolocellular Carcinoma

Symptoms & Phenotypes for Cholangiolocellular Carcinoma

UMLS symptoms related to Cholangiolocellular Carcinoma:


abdominal pain, malaise

MGI Mouse Phenotypes related to Cholangiolocellular Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.92 ABCB1 CDKN2A EZH2 PROM1

Drugs & Therapeutics for Cholangiolocellular Carcinoma

Search Clinical Trials , NIH Clinical Center for Cholangiolocellular Carcinoma

Genetic Tests for Cholangiolocellular Carcinoma

Anatomical Context for Cholangiolocellular Carcinoma

MalaCards organs/tissues related to Cholangiolocellular Carcinoma:

41
Liver

Publications for Cholangiolocellular Carcinoma

Articles related to Cholangiolocellular Carcinoma:

(show top 50) (show all 68)
# Title Authors PMID Year
1
Expression of fatty-acid-binding protein 5 in intrahepatic and extrahepatic cholangiocarcinoma: the possibility of different energy metabolisms in anatomical location. 38
31432248 2019
2
Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma. 38
31261448 2019
3
Immunohistochemical and molecular features of cholangiolocellular carcinoma are similar to well-differentiated intrahepatic cholangiocarcinoma. 38
31186529 2019
4
Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern May Be Characterized by ARID1A Genetic Alterations. 38
30520820 2019
5
[A case of resected synchronous hepatocellular and cholangiolocellular carcinoma in the background of resolved hepatitis B virus infection]. 38
31080224 2019
6
Synchronous double primary hepatic cancer consisting of hepatocellular carcinoma and cholangiolocellular carcinoma: a case report. 38
30119698 2018
7
[A case of cholangiolocellular carcinoma found to be hepatic hemangioma at 16-month follow up]. 38
30531114 2018
8
Successful local treatment for repeated hepatic recurrences of cholangiolocellular carcinoma: a report on a long-term survivor. 38
29198012 2017
9
Gadoxetic acid disodium-enhanced MR imaging of cholangiolocellular carcinoma of the liver: imaging characteristics and histopathological correlations. 38
28439650 2017
10
Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma. 38
28951464 2017
11
Cholangiolocellular Carcinoma in a Young Patient Who Showed Sustained Virological Response after Treatment for Hepatitis C Virus Infection. 38
28943584 2017
12
Intrahepatic Cholangiolocellular and Cholangiocellular Carcinoma - Differences in the 18F-FDG PET/CT Findings. 38
28943569 2017
13
Skull metastasis from cholangiolocellular carcinoma. 38
28462886 2017
14
Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report. 38
28916905 2017
15
Successful surgical resection of ruptured cholangiolocellular carcinoma: A rare case of a primary hepatic tumor. 38
28652894 2017
16
Clinicopathological, radiologic, and molecular study of 23 combined hepatocellular-cholangiocarcinomas with stem cell features, cholangiolocellular type. 38
28431889 2017
17
Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity. 38
28126467 2017
18
Intrahepatic cholangiocarcinoma. 38
28094162 2017
19
Dynamic CT findings of cholangiolocellular carcinoma: correlation with angiography-assisted CT and histopathology. 38
27747442 2017
20
Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance. 38
27634656 2017
21
A case of cholangiolocellular carcinoma featuring intratumoral hepatic artery penetration: A case report. 38
28458143 2017
22
S-1 monotherapy in a patient with cholangiolocellular carcinoma: A case report. 38
28105354 2016
23
Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma. 38
27748735 2016
24
Synchronous double cancers of primary hepatocellular carcinoma and cholangiolocellular carcinoma: a case report. 38
27878570 2016
25
Claudins-4 and -7 might be valuable markers to distinguish hepatocellular carcinoma from cholangiocarcinoma. 38
27444172 2016
26
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis. 38
27418411 2016
27
Cholangiolocellular carcinoma with rapid progression initially showing abnormally elevated serum alfa-fetoprotein. 38
27363839 2016
28
Cholangiolocellular Carcinoma of the Liver Exhibiting High F-18 FDG Uptake. 38
27344994 2016
29
Repeated Hepatectomy for Recurrent Intrahepatic Cholangiolocellular Carcinoma: Report of a Case. 38
27345000 2016
30
Intrahepatic cholangiocarcinoma and cholangiolocellular carcinoma in cirrhosis and chronic viral hepatitis. 38
25253466 2015
31
Giant Cholangiolocellular Carcinoma With Early Recurrence That Was Difficult to Distinguish From Cholangiocellular Carcinoma: Report of a Case. 38
26414834 2015
32
Cholangiolocellular carcinoma with satellite nodules showing intermediate differentiation. 38
26157757 2015
33
Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions. 38
25289642 2015
34
Pathogenesis of Cholangiolocellular Carcinoma: Possibility of an Interlobular Duct Origin. 38
26179521 2015
35
Integrins αvβ6, α6β4 and α3β1 are down-regulated in cholangiolocellular carcinoma but not cholangiocarcinoma. 38
24552196 2014
36
Long-term survival of patients with cholangiolocellular carcinoma after curative hepatectomy. 38
24633664 2014
37
Hypervascular benign and malignant liver tumors that require differentiation from hepatocellular carcinoma: key points of imaging diagnosis. 38
24944999 2014
38
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. 38
24487593 2014
39
Repeat hepatectomy for intrahepatic recurrence of cholangiolocellular carcinoma. 38
24693685 2013
40
High expression of cancer stem cell markers in cholangiolocellular carcinoma. 38
23192764 2013
41
Cholangiolocellular carcinoma in a pediatric patient with small duct sclerosing cholangitis: a case report. 38
23397537 2012
42
[A resected case of recurrent intrahepatic cholangiocellular carcinoma with a cholangiocellular carcinoma component after transcatheter arterial embolization and radiofrequency ablation]. 38
23267957 2012
43
[A case of advanced cholangiolocellular carcinoma successfully treated by neoadjuvant chemotherapy with gemcitabine followed by radical resection]. 38
23267994 2012
44
[Resection of cholangiolocellular carcinoma successfully responding to neoadjuvant hepatic arterial infusion chemotherapy - report of a case]. 38
22790060 2012
45
Morphometric and immunohistochemical study of cholangiolocellular carcinoma: comparison with non-neoplastic cholangiole, interlobular duct and septal duct. 38
22179577 2012
46
[A case of cholangiolocellular carcinoma combined with intrahepatic cholangiocarcinoma diagnosed after 4 years follow-up for hepatic hemangioma]. 38
22306546 2012
47
A case of a large cholangiolocellular carcinoma. 38
26189636 2011
48
Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking ductular reaction. 38
21344355 2011
49
Imaging of cholangiolocellular carcinoma of the liver. 38
19781883 2010
50
Chronic schistosomiasis japonica is an independent adverse prognostic factor for survival in hepatocellular carcinoma patients who have undergone hepatic resection: clinicopathological and prognostic analysis of 198 consecutive patients. 38
19771467 2009

Variations for Cholangiolocellular Carcinoma

Expression for Cholangiolocellular Carcinoma

Search GEO for disease gene expression data for Cholangiolocellular Carcinoma.

Pathways for Cholangiolocellular Carcinoma

GO Terms for Cholangiolocellular Carcinoma

Cellular components related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.46 PROM1 MUC1 ABCC3 ABCC1
2 apical plasma membrane GO:0016324 9.13 PROM1 MUC1 ABCB1
3 vacuolar membrane GO:0005774 8.62 ABCC3 ABCC1

Biological processes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid translocation GO:0045332 9.16 ABCC1 ABCB1
2 drug transmembrane transport GO:0006855 8.65 ABCC1
3 xenobiotic transport GO:0042908 8.32 ABCC1

Molecular functions related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.33 ABCC3 ABCC1 ABCB1
2 transporter activity GO:0005215 8.96 ABCB1
3 xenobiotic transmembrane transporting ATPase activity GO:0008559 8.96 ABCC1 ABCB1
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 8.8 ABCC3 ABCC1 ABCB1

Sources for Cholangiolocellular Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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