MCID: CHL040
MIFTS: 30

Cholangiolocellular Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cholangiolocellular Carcinoma

MalaCards integrated aliases for Cholangiolocellular Carcinoma:

Name: Cholangiolocellular Carcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7642
NCIt 50 C41617
UMLS 73 C1516490

Summaries for Cholangiolocellular Carcinoma

MalaCards based summary : Cholangiolocellular Carcinoma is related to cholangiocarcinoma and hepatitis, and has symptoms including abdominal pain and malaise. An important gene associated with Cholangiolocellular Carcinoma is EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit), and among its related pathways/superpathways are MicroRNAs in cancer and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cholangiolocellular Carcinoma

Diseases related to Cholangiolocellular Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 cholangiocarcinoma 28.0 CDKN2A EZH2 MUC1 PROM1
2 hepatitis 10.3
3 pancreatic mucinous cystadenoma 10.2 EZH2 MUC1
4 hepatocellular carcinoma 10.1
5 gastrointestinal carcinoma 10.1 ABCB1 MUC1
6 small intestinal adenocarcinoma 9.9 MUC1 PROM1
7 bile duct carcinoma 9.9 ABCC3 MUC1
8 hepatitis c virus 9.8
9 alcoholic liver cirrhosis 9.8
10 liver cirrhosis 9.8
11 sclerosing cholangitis 9.8
12 hepatitis c 9.8
13 viral hepatitis 9.8
14 intrahepatic cholangiocarcinoma 9.8
15 adenoma 9.8
16 cholangitis 9.8
17 malignant peritoneal mesothelioma 9.8 CDKN2A MUC1
18 mucinous bronchioloalveolar adenocarcinoma 9.8 CDKN2A MUC1
19 endometrial mucinous adenocarcinoma 9.8 CDKN2A MUC1
20 sarcomatoid mesothelioma 9.8 CDKN2A MUC1
21 pleomorphic liposarcoma 9.8 CDKN2A MUC1
22 ischemic fasciitis 9.8 CDKN2A MUC1
23 well-differentiated liposarcoma 9.8 CDKN2A MUC1
24 dedifferentiated liposarcoma 9.7 CDKN2A MUC1
25 meningeal melanocytoma 9.7 CDKN2A MUC1
26 cervix carcinoma 9.7 ABCB1 CDKN2A
27 biliary tract neoplasm 9.7 CDKN2A MUC1
28 peritoneal mesothelioma 9.7 CDKN2A MUC1
29 acute lymphoblastic leukemia, childhood 9.7 ABCB1 CDKN2A
30 mucinous adenocarcinoma 9.7 CDKN2A MUC1
31 gastric adenosquamous carcinoma 9.7 CDKN2A PROM1
32 pancreatic ductal carcinoma 9.6 CDKN2A MUC1
33 neurofibroma 9.6 CDKN2A MUC1
34 cholecystitis 9.6 CDKN2A MUC1
35 chordoma 9.5 CDKN2A MUC1
36 mesothelioma, malignant 9.4 CDKN2A MUC1
37 adamantinoma of long bones 9.4 ABCB1 CDKN2A EZH2
38 malignant peripheral nerve sheath tumor 9.3 CDKN2A MUC1
39 plasmablastic lymphoma 9.3 ABCB1 CDKN2A MUC1
40 mantle cell lymphoma 9.1 CDKN2A EZH2
41 gastrointestinal system cancer 9.1 CDKN2A PROM1
42 cell type cancer 9.1 CDKN2A MUC1 PROM1
43 pancreas adenocarcinoma 9.1 CDKN2A MUC1 PROM1

Graphical network of the top 20 diseases related to Cholangiolocellular Carcinoma:



Diseases related to Cholangiolocellular Carcinoma

Symptoms & Phenotypes for Cholangiolocellular Carcinoma

UMLS symptoms related to Cholangiolocellular Carcinoma:


abdominal pain, malaise

GenomeRNAi Phenotypes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.23 ABCB1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.23 ABCB1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.23 ABCB1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.23 ABCB1 ABCC3 EZH2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.23 EZH2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.23 ABCB1

MGI Mouse Phenotypes related to Cholangiolocellular Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 ABCC3 CDKN2A EZH2 PROM1 ABCB1
2 no phenotypic analysis MP:0003012 8.92 ABCB1 CDKN2A EZH2 PROM1

Drugs & Therapeutics for Cholangiolocellular Carcinoma

Search Clinical Trials , NIH Clinical Center for Cholangiolocellular Carcinoma

Genetic Tests for Cholangiolocellular Carcinoma

Anatomical Context for Cholangiolocellular Carcinoma

MalaCards organs/tissues related to Cholangiolocellular Carcinoma:

41
Liver

Publications for Cholangiolocellular Carcinoma

Articles related to Cholangiolocellular Carcinoma:

(show all 41)
# Title Authors Year
1
Successful surgical resection of ruptured cholangiolocellular carcinoma: A rare case of a primary hepatic tumor. ( 28652894 )
2017
2
Successful local treatment for repeated hepatic recurrences of cholangiolocellular carcinoma: a report on a long-term survivor. ( 29198012 )
2017
3
Cholangiolocellular Carcinoma in a Young Patient Who Showed Sustained Virological Response after Treatment for Hepatitis C Virus Infection. ( 28943584 )
2017
4
Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report. ( 28916905 )
2017
5
Skull metastasis from cholangiolocellular carcinoma. ( 28462886 )
2017
6
Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity. ( 28126467 )
2017
7
Gadoxetic acid disodium-enhanced MR imaging of cholangiolocellular carcinoma of the liver: imaging characteristics and histopathological correlations. ( 28439650 )
2017
8
A case of cholangiolocellular carcinoma featuring intratumoral hepatic artery penetration: A case report. ( 28458143 )
2017
9
Synchronous double cancers of primary hepatocellular carcinoma and cholangiolocellular carcinoma: a case report. ( 27878570 )
2016
10
Cholangiolocellular carcinoma with rapid progression initially showing abnormally elevated serum alfa-fetoprotein. ( 27363839 )
2016
11
Cholangiolocellular Carcinoma of the Liver Exhibiting High F-18 FDG Uptake. ( 27344994 )
2016
12
Repeated Hepatectomy for Recurrent Intrahepatic Cholangiolocellular Carcinoma: Report of a Case. ( 27345000 )
2016
13
Dynamic CT findings of cholangiolocellular carcinoma: correlation with angiography-assisted CT and histopathology. ( 27747442 )
2016
14
Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma. ( 27748735 )
2016
15
S-1 monotherapy in a patient with cholangiolocellular carcinoma: A case report. ( 28105354 )
2016
16
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis. ( 27418411 )
2016
17
Pathogenesis of Cholangiolocellular Carcinoma: Possibility of an Interlobular Duct Origin. ( 26179521 )
2015
18
Giant Cholangiolocellular Carcinoma With Early Recurrence That Was Difficult to Distinguish From Cholangiocellular Carcinoma: Report of a Case. ( 26414834 )
2015
19
Cholangiolocellular carcinoma with satellite nodules showing intermediate differentiation. ( 26157757 )
2015
20
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. ( 24487593 )
2014
21
Long-term survival of patients with cholangiolocellular carcinoma after curative hepatectomy. ( 24633664 )
2014
22
Integrins I+vI^6, I+6I^4 and I+3I^1 are down-regulated in cholangiolocellular carcinoma but not cholangiocarcinoma. ( 24552196 )
2014
23
Intrahepatic cholangiocarcinoma and cholangiolocellular carcinoma in cirrhosis and chronic viral hepatitis. ( 25253466 )
2014
24
High expression of cancer stem cell markers in cholangiolocellular carcinoma. ( 23192764 )
2013
25
Repeat hepatectomy for intrahepatic recurrence of cholangiolocellular carcinoma. ( 24693685 )
2013
26
Cholangiolocellular carcinoma in a pediatric patient with small duct sclerosing cholangitis: a case report. ( 23397537 )
2012
27
Morphometric and immunohistochemical study of cholangiolocellular carcinoma: comparison with non-neoplastic cholangiole, interlobular duct and septal duct. ( 22179577 )
2012
28
Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking ductular reaction. ( 21344355 )
2011
29
A case of a large cholangiolocellular carcinoma. ( 26189636 )
2011
30
Imaging of cholangiolocellular carcinoma of the liver. ( 19781883 )
2010
31
A case of cholangiolocellular carcinoma asynchronously developing 3 years after the resection of hepatocellular carcinoma. ( 26192297 )
2009
32
Cholangiolocellular carcinoma of the liver: imaging findings. ( 19820492 )
2009
33
A case of well-differentiated cholangiolocellular carcinoma visualized with contrast-enhanced ultrasonography using Sonazoid. ( 19208040 )
2009
34
Cholangiolocellular carcinoma containing hepatocellular carcinoma and cholangiocellular carcinoma, extremely rare tumor of the liver:a case report. ( 18319561 )
2008
35
Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. ( 18393293 )
2008
36
Synchronously resected double primary hepatic cancers - hepatocellular carcinoma and cholangiolocellular carcinoma. ( 17139434 )
2006
37
Clinicopathologic study on cholangiolocellular carcinoma. ( 11182037 )
2001
38
Cholangiolocellular carcinoma of the liver: CT and MR findings. ( 11045707 )
2000
39
Hepatic recurrence of cholangiolocellular carcinoma: report of a case. ( 8884337 )
1996
40
CHOLANGIOLOCELLULAR CARCINOMA OF THE LIVER. ( 14207070 )
1964
41
Cholangiolocellular carcinoma of the liver. ( 13663020 )
1959

Variations for Cholangiolocellular Carcinoma

Expression for Cholangiolocellular Carcinoma

Search GEO for disease gene expression data for Cholangiolocellular Carcinoma.

Pathways for Cholangiolocellular Carcinoma

GO Terms for Cholangiolocellular Carcinoma

Cellular components related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 ABCB1 MUC1 PROM1

Biological processes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug transmembrane transport GO:0006855 8.96 ABCB1 ABCC3
2 xenobiotic transport GO:0042908 8.62 ABCB1 ABCC3

Molecular functions related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity, coupled to transmembrane movement of substances GO:0042626 8.96 ABCB1 ABCC3
2 xenobiotic transmembrane transporting ATPase activity GO:0008559 8.62 ABCB1 ABCC3

Sources for Cholangiolocellular Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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