MCID: CHL040
MIFTS: 32

Cholangiolocellular Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cholangiolocellular Carcinoma

MalaCards integrated aliases for Cholangiolocellular Carcinoma:

Name: Cholangiolocellular Carcinoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7642
NCIt 49 C41617
UMLS 71 C1516490

Summaries for Cholangiolocellular Carcinoma

MalaCards based summary : Cholangiolocellular Carcinoma is related to intrahepatic cholangiocarcinoma and bile duct adenoma, and has symptoms including abdominal pain and malaise. An important gene associated with Cholangiolocellular Carcinoma is KRT19 (Keratin 19), and among its related pathways/superpathways are MicroRNAs in cancer and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Affiliated tissues include liver, lung and ovary, and related phenotypes are immune system and neoplasm

Related Diseases for Cholangiolocellular Carcinoma

Diseases related to Cholangiolocellular Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 intrahepatic cholangiocarcinoma 30.5 PROM1 MUC1 KRT19 ARID1A
2 bile duct adenoma 29.1 MUC1 KRT19 EZH2 CDKN2A
3 hepatocellular carcinoma 27.7 PROM1 KRT19 EZH2 CDKN2A ARID1A ABCC3
4 cholangiocarcinoma 10.7
5 liver cirrhosis 10.4
6 lipoadenoma 10.3 MUC1 KRT19
7 viral hepatitis 10.3
8 rare tumor 10.3
9 syringocystadenoma papilliferum 10.3 MUC1 KRT19
10 pericardial mesothelioma 10.3 MUC1 KRT19
11 biliary tract benign neoplasm 10.3 MUC1 KRT19
12 sarcomatous intrahepatic cholangiocarcinoma 10.3 MUC1 KRT19
13 limbal stem cell deficiency 10.3 MUC1 KRT19
14 mucinous tubular and spindle renal cell carcinoma 10.3 MUC1 KRT19
15 benign peritoneal mesothelioma 10.3 MUC1 KRT19
16 monophasic synovial sarcoma 10.2 MUC1 KRT19
17 microcystic adenoma 10.2 MUC1 KRT19
18 syringoma 10.2 MUC1 KRT19
19 lymphoepithelioma-like carcinoma 10.2 MUC1 KRT19
20 uterine sarcoma 10.2 ABCC1 ABCB1
21 convulsions, familial infantile, with paroxysmal choreoathetosis 10.2
22 hepatitis c virus 10.2
23 hemangioma 10.2
24 hemangioma of liver 10.2
25 temporal lobe neoplasm 10.2 ABCC1 ABCB1
26 colchicine resistance 10.2 ABCC1 ABCB1
27 microsporidiosis 10.2 ABCC1 ABCB1
28 colorectal cancer, hereditary nonpolyposis, type 8 10.1 PROM1 MUC1
29 gastrointestinal carcinoma 10.1 MUC1 KRT19 ABCB1
30 polycystic liver disease 1 with or without kidney cysts 10.1 MUC1 KRT19
31 breast cancer 10.1
32 fibrosis of extraocular muscles, congenital, 1 10.1
33 pulmonary fibrosis, idiopathic 10.1
34 schistosoma mansoni infection, susceptibility/ 10.1
35 caroli disease, isolated 10.1
36 gastrointestinal stromal tumor 10.1
37 cholangitis, primary sclerosing 10.1
38 intestinal schistosomiasis 10.1
39 caroli disease 10.1
40 adrenal cortical adenoma 10.1
41 leukemia 10.1
42 schistosomiasis 10.1
43 sclerosing cholangitis 10.1
44 idiopathic interstitial pneumonia 10.1
45 pulmonary fibrosis 10.1
46 tubular adenocarcinoma 10.1
47 adenoma 10.1
48 cholangitis 10.1
49 adenofibroma 10.1 MUC1 KRT19 ARID1A
50 mediastinum sarcoma 10.0 KRT19 CDKN2A

Graphical network of the top 20 diseases related to Cholangiolocellular Carcinoma:



Diseases related to Cholangiolocellular Carcinoma

Symptoms & Phenotypes for Cholangiolocellular Carcinoma

UMLS symptoms related to Cholangiolocellular Carcinoma:


abdominal pain, malaise

MGI Mouse Phenotypes related to Cholangiolocellular Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.8 ABCB1 ABCC1 ARID1A CDKN2A CHST4 EZH2
2 neoplasm MP:0002006 9.55 ARID1A CDKN2A EZH2 KRT19 PROM1
3 nervous system MP:0003631 9.5 ABCB1 ABCC1 ARID1A CDKN2A EZH2 KRT19
4 no phenotypic analysis MP:0003012 9.1 ABCB1 ARID1A CDKN2A EZH2 KRT19 PROM1

Drugs & Therapeutics for Cholangiolocellular Carcinoma

Search Clinical Trials , NIH Clinical Center for Cholangiolocellular Carcinoma

Genetic Tests for Cholangiolocellular Carcinoma

Anatomical Context for Cholangiolocellular Carcinoma

MalaCards organs/tissues related to Cholangiolocellular Carcinoma:

40
Liver, Lung, Ovary, Colon, Kidney, Breast, Cervix

Publications for Cholangiolocellular Carcinoma

Articles related to Cholangiolocellular Carcinoma:

(show top 50) (show all 72)
# Title Authors PMID Year
1
A case of focal confluent hepatic fibrosis in the patient with hepatitis C virus-related liver cirrhosis: a mimic of cholangiolocellular carcinoma. 61
32025800 2020
2
Distinctive clinicopathological features and KRAS and IDH1/2 mutation status of cholangiolocellular carcinoma. 61
31733634 2020
3
Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma. 61
31261448 2019
4
Right Hepatic Vein Reconstruction with an Autologous Jugular Vein Graft to Expand the Surgical Indications for Liver Tumors. 61
31482408 2019
5
Immunohistochemical and molecular features of cholangiolocellular carcinoma are similar to well-differentiated intrahepatic cholangiocarcinoma. 61
31186529 2019
6
Characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection: a case report. 61
31486939 2019
7
Expression of fatty-acid-binding protein 5 in intrahepatic and extrahepatic cholangiocarcinoma: the possibility of different energy metabolisms in anatomical location. 61
31432248 2019
8
Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern May Be Characterized by ARID1A Genetic Alterations. 61
30520820 2019
9
[A case of resected synchronous hepatocellular and cholangiolocellular carcinoma in the background of resolved hepatitis B virus infection]. 61
31080224 2019
10
Synchronous double primary hepatic cancer consisting of hepatocellular carcinoma and cholangiolocellular carcinoma: a case report. 61
30119698 2018
11
[A case of cholangiolocellular carcinoma found to be hepatic hemangioma at 16-month follow up]. 61
30531114 2018
12
Successful local treatment for repeated hepatic recurrences of cholangiolocellular carcinoma: a report on a long-term survivor. 61
29198012 2017
13
Gadoxetic acid disodium-enhanced MR imaging of cholangiolocellular carcinoma of the liver: imaging characteristics and histopathological correlations. 61
28439650 2017
14
Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma. 61
28951464 2017
15
Cholangiolocellular Carcinoma in a Young Patient Who Showed Sustained Virological Response after Treatment for Hepatitis C Virus Infection. 61
28943584 2017
16
Intrahepatic Cholangiolocellular and Cholangiocellular Carcinoma - Differences in the 18F-FDG PET/CT Findings. 61
28943569 2017
17
Skull metastasis from cholangiolocellular carcinoma. 61
28462886 2017
18
Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report. 61
28916905 2017
19
Successful surgical resection of ruptured cholangiolocellular carcinoma: A rare case of a primary hepatic tumor. 61
28652894 2017
20
Clinicopathological, radiologic, and molecular study of 23 combined hepatocellular-cholangiocarcinomas with stem cell features, cholangiolocellular type. 61
28431889 2017
21
Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity. 61
28126467 2017
22
Intrahepatic cholangiocarcinoma. 61
28094162 2017
23
Dynamic CT findings of cholangiolocellular carcinoma: correlation with angiography-assisted CT and histopathology. 61
27747442 2017
24
Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance. 61
27634656 2017
25
A case of cholangiolocellular carcinoma featuring intratumoral hepatic artery penetration: A case report. 61
28458143 2017
26
S-1 monotherapy in a patient with cholangiolocellular carcinoma: A case report. 61
28105354 2016
27
Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma. 61
27748735 2016
28
Synchronous double cancers of primary hepatocellular carcinoma and cholangiolocellular carcinoma: a case report. 61
27878570 2016
29
Claudins-4 and -7 might be valuable markers to distinguish hepatocellular carcinoma from cholangiocarcinoma. 61
27444172 2016
30
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis. 61
27418411 2016
31
Cholangiolocellular carcinoma with rapid progression initially showing abnormally elevated serum alfa-fetoprotein. 61
27363839 2016
32
Cholangiolocellular Carcinoma of the Liver Exhibiting High F-18 FDG Uptake. 61
27344994 2016
33
Repeated Hepatectomy for Recurrent Intrahepatic Cholangiolocellular Carcinoma: Report of a Case. 61
27345000 2016
34
Intrahepatic cholangiocarcinoma and cholangiolocellular carcinoma in cirrhosis and chronic viral hepatitis. 61
25253466 2015
35
Cholangiolocellular carcinoma with satellite nodules showing intermediate differentiation. 61
26157757 2015
36
Giant Cholangiolocellular Carcinoma With Early Recurrence That Was Difficult to Distinguish From Cholangiocellular Carcinoma: Report of a Case. 61
26414834 2015
37
Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions. 61
25289642 2015
38
Pathogenesis of Cholangiolocellular Carcinoma: Possibility of an Interlobular Duct Origin. 61
26179521 2015
39
Integrins αvβ6, α6β4 and α3β1 are down-regulated in cholangiolocellular carcinoma but not cholangiocarcinoma. 61
24552196 2014
40
Long-term survival of patients with cholangiolocellular carcinoma after curative hepatectomy. 61
24633664 2014
41
Hypervascular benign and malignant liver tumors that require differentiation from hepatocellular carcinoma: key points of imaging diagnosis. 61
24944999 2014
42
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. 61
24487593 2014
43
Repeat hepatectomy for intrahepatic recurrence of cholangiolocellular carcinoma. 61
24693685 2013
44
High expression of cancer stem cell markers in cholangiolocellular carcinoma. 61
23192764 2013
45
[A case of advanced cholangiolocellular carcinoma successfully treated by neoadjuvant chemotherapy with gemcitabine followed by radical resection]. 61
23267994 2012
46
Cholangiolocellular carcinoma in a pediatric patient with small duct sclerosing cholangitis: a case report. 61
23397537 2012
47
[A resected case of recurrent intrahepatic cholangiocellular carcinoma with a cholangiocellular carcinoma component after transcatheter arterial embolization and radiofrequency ablation]. 61
23267957 2012
48
[Resection of cholangiolocellular carcinoma successfully responding to neoadjuvant hepatic arterial infusion chemotherapy - report of a case]. 61
22790060 2012
49
Morphometric and immunohistochemical study of cholangiolocellular carcinoma: comparison with non-neoplastic cholangiole, interlobular duct and septal duct. 61
22179577 2012
50
[A case of cholangiolocellular carcinoma combined with intrahepatic cholangiocarcinoma diagnosed after 4 years follow-up for hepatic hemangioma]. 61
22306546 2012

Variations for Cholangiolocellular Carcinoma

Expression for Cholangiolocellular Carcinoma

Search GEO for disease gene expression data for Cholangiolocellular Carcinoma.

Pathways for Cholangiolocellular Carcinoma

GO Terms for Cholangiolocellular Carcinoma

Biological processes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid translocation GO:0045332 9.26 ABCC1 ABCB1
2 xenobiotic transport GO:0042908 9.16 ABCC3 ABCC1
3 transepithelial transport GO:0070633 8.96 ABCC1 ABCB1
4 export across plasma membrane GO:0140115 8.62 ABCC1 ABCB1

Molecular functions related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.5 ABCC3 ABCC1 ABCB1
2 efflux transmembrane transporter activity GO:0015562 9.26 ABCC1 ABCB1
3 xenobiotic transmembrane transporting ATPase activity GO:0008559 9.16 ABCC1 ABCB1
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCC3 ABCC1 ABCB1
5 xenobiotic transmembrane transporter activity GO:0042910 8.8 ABCC3 ABCC1 ABCB1

Sources for Cholangiolocellular Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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