MCID: CHL040
MIFTS: 30

Cholangiolocellular Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cholangiolocellular Carcinoma

MalaCards integrated aliases for Cholangiolocellular Carcinoma:

Name: Cholangiolocellular Carcinoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7642
NCIt 51 C41617
UMLS 74 C1516490

Summaries for Cholangiolocellular Carcinoma

MalaCards based summary : Cholangiolocellular Carcinoma is related to bile duct adenoma and hepatocellular carcinoma, and has symptoms including abdominal pain and malaise. An important gene associated with Cholangiolocellular Carcinoma is ABCB1 (ATP Binding Cassette Subfamily B Member 1), and among its related pathways/superpathways are MicroRNAs in cancer and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include liver, lung and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cholangiolocellular Carcinoma

Diseases related to Cholangiolocellular Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 bile duct adenoma 29.5 CDKN2A EZH2 MUC1
2 hepatocellular carcinoma 10.4
3 cholangiocarcinoma 10.3
4 intrahepatic cholangiocarcinoma 10.3
5 hepatitis 10.2
6 gastrointestinal carcinoma 10.1 ABCB1 MUC1
7 pancreatic mucinous cystadenoma 10.1 EZH2 MUC1
8 hepatitis c virus 10.0
9 liver cirrhosis 10.0
10 sclerosing cholangitis 10.0
11 hepatitis c 10.0
12 viral hepatitis 10.0
13 adenoma 10.0
14 cholangitis 10.0
15 cervix carcinoma 9.9 ABCB1 CDKN2A
16 acute lymphoblastic leukemia, childhood 9.9 ABCB1 CDKN2A
17 malignant peritoneal mesothelioma 9.9 CDKN2A MUC1
18 peritoneal mesothelioma 9.9 CDKN2A MUC1
19 endometrial mucinous adenocarcinoma 9.9 CDKN2A MUC1
20 mucinous adenocarcinoma 9.9 CDKN2A MUC1
21 sarcomatoid mesothelioma 9.9 CDKN2A MUC1
22 pleomorphic liposarcoma 9.9 CDKN2A MUC1
23 ischemic fasciitis 9.9 CDKN2A MUC1
24 mucinous bronchioloalveolar adenocarcinoma 9.9 CDKN2A MUC1
25 well-differentiated liposarcoma 9.9 CDKN2A MUC1
26 meningeal melanocytoma 9.9 CDKN2A MUC1
27 pancreatic ductal carcinoma 9.9 CDKN2A MUC1
28 intrahepatic cholestasis of pregnancy 9.9 ABCB1 ABCC3
29 neurofibroma 9.9 CDKN2A MUC1
30 gastric adenosquamous carcinoma 9.8 CDKN2A PROM1
31 cholecystitis 9.8 CDKN2A MUC1
32 laryngeal disease 9.8 CDKN2A PROM1
33 malignant pleural mesothelioma 9.8 CDKN2A MUC1
34 chordoma 9.8 CDKN2A MUC1
35 supratentorial cancer 9.8 CDKN2A PROM1
36 malignant peripheral nerve sheath tumor 9.8 CDKN2A MUC1
37 cerebrum cancer 9.8 CDKN2A PROM1
38 small cell cancer of the lung 9.8 ABCB1 CDKN2A
39 central nervous system cancer 9.8 CDKN2A PROM1
40 nervous system cancer 9.8 CDKN2A PROM1
41 endocrine gland cancer 9.8 CDKN2A MUC1
42 mesothelioma, malignant 9.7 CDKN2A MUC1
43 gastrointestinal system cancer 9.7 CDKN2A PROM1
44 mantle cell lymphoma 9.7 CDKN2A EZH2
45 adamantinoma of long bones 9.7 ABCB1 CDKN2A EZH2
46 plasmablastic lymphoma 9.7 ABCB1 CDKN2A MUC1
47 pancreas adenocarcinoma 9.6 CDKN2A MUC1 PROM1
48 gallbladder cancer 9.5 CDKN2A MUC1
49 large intestine cancer 9.1 ABCB1 CDKN2A EZH2 MUC1 PROM1

Graphical network of the top 20 diseases related to Cholangiolocellular Carcinoma:



Diseases related to Cholangiolocellular Carcinoma

Symptoms & Phenotypes for Cholangiolocellular Carcinoma

UMLS symptoms related to Cholangiolocellular Carcinoma:


abdominal pain, malaise

GenomeRNAi Phenotypes related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.23 ABCB1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.23 ABCB1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.23 ABCB1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.23 ABCB1 ABCC3 EZH2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.23 EZH2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.23 ABCB1

MGI Mouse Phenotypes related to Cholangiolocellular Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 ABCB1 ABCC3 CDKN2A EZH2 PROM1
2 no phenotypic analysis MP:0003012 8.92 ABCB1 CDKN2A EZH2 PROM1

Drugs & Therapeutics for Cholangiolocellular Carcinoma

Search Clinical Trials , NIH Clinical Center for Cholangiolocellular Carcinoma

Genetic Tests for Cholangiolocellular Carcinoma

Anatomical Context for Cholangiolocellular Carcinoma

MalaCards organs/tissues related to Cholangiolocellular Carcinoma:

42
Liver, Lung, Bone, Cervix, Pancreas

Publications for Cholangiolocellular Carcinoma

Articles related to Cholangiolocellular Carcinoma:

(show all 43)
# Title Authors Year
1
Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern May Be Characterized by ARID1A Genetic Alterations. ( 30520820 )
2019
2
Synchronous double primary hepatic cancer consisting of hepatocellular carcinoma and cholangiolocellular carcinoma: a case report. ( 30119698 )
2018
3
Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity. ( 28126467 )
2017
4
Successful local treatment for repeated hepatic recurrences of cholangiolocellular carcinoma: a report on a long-term survivor. ( 29198012 )
2017
5
Cholangiolocellular Carcinoma in a Young Patient Who Showed Sustained Virological Response after Treatment for Hepatitis C Virus Infection. ( 28943584 )
2017
6
Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report. ( 28916905 )
2017
7
Successful surgical resection of ruptured cholangiolocellular carcinoma: A rare case of a primary hepatic tumor. ( 28652894 )
2017
8
Skull metastasis from cholangiolocellular carcinoma. ( 28462886 )
2017
9
A case of cholangiolocellular carcinoma featuring intratumoral hepatic artery penetration: A case report. ( 28458143 )
2017
10
Gadoxetic acid disodium-enhanced MR imaging of cholangiolocellular carcinoma of the liver: imaging characteristics and histopathological correlations. ( 28439650 )
2017
11
Dynamic CT findings of cholangiolocellular carcinoma: correlation with angiography-assisted CT and histopathology. ( 27747442 )
2017
12
S-1 monotherapy in a patient with cholangiolocellular carcinoma: A case report. ( 28105354 )
2016
13
Synchronous double cancers of primary hepatocellular carcinoma and cholangiolocellular carcinoma: a case report. ( 27878570 )
2016
14
Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma. ( 27748735 )
2016
15
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis. ( 27418411 )
2016
16
Cholangiolocellular carcinoma with rapid progression initially showing abnormally elevated serum alfa-fetoprotein. ( 27363839 )
2016
17
Repeated Hepatectomy for Recurrent Intrahepatic Cholangiolocellular Carcinoma: Report of a Case. ( 27345000 )
2016
18
Cholangiolocellular Carcinoma of the Liver Exhibiting High F-18 FDG Uptake. ( 27344994 )
2016
19
Giant Cholangiolocellular Carcinoma With Early Recurrence That Was Difficult to Distinguish From Cholangiocellular Carcinoma: Report of a Case. ( 26414834 )
2015
20
Pathogenesis of Cholangiolocellular Carcinoma: Possibility of an Interlobular Duct Origin. ( 26179521 )
2015
21
Cholangiolocellular carcinoma with satellite nodules showing intermediate differentiation. ( 26157757 )
2015
22
Intrahepatic cholangiocarcinoma and cholangiolocellular carcinoma in cirrhosis and chronic viral hepatitis. ( 25253466 )
2015
23
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. ( 24487593 )
2014
24
Long-term survival of patients with cholangiolocellular carcinoma after curative hepatectomy. ( 24633664 )
2014
25
Integrins αvβ6, α6β4 and α3β1 are down-regulated in cholangiolocellular carcinoma but not cholangiocarcinoma. ( 24552196 )
2014
26
Repeat hepatectomy for intrahepatic recurrence of cholangiolocellular carcinoma. ( 24693685 )
2013
27
High expression of cancer stem cell markers in cholangiolocellular carcinoma. ( 23192764 )
2013
28
Cholangiolocellular carcinoma in a pediatric patient with small duct sclerosing cholangitis: a case report. ( 23397537 )
2012
29
Morphometric and immunohistochemical study of cholangiolocellular carcinoma: comparison with non-neoplastic cholangiole, interlobular duct and septal duct. ( 22179577 )
2012
30
A case of a large cholangiolocellular carcinoma. ( 26189636 )
2011
31
Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking ductular reaction. ( 21344355 )
2011
32
Imaging of cholangiolocellular carcinoma of the liver. ( 19781883 )
2010
33
A case of cholangiolocellular carcinoma asynchronously developing 3 years after the resection of hepatocellular carcinoma. ( 26192297 )
2009
34
Cholangiolocellular carcinoma of the liver: imaging findings. ( 19820492 )
2009
35
A case of well-differentiated cholangiolocellular carcinoma visualized with contrast-enhanced ultrasonography using Sonazoid. ( 19208040 )
2009
36
Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. ( 18393293 )
2008
37
Cholangiolocellular carcinoma containing hepatocellular carcinoma and cholangiocellular carcinoma, extremely rare tumor of the liver:a case report. ( 18319561 )
2008
38
Synchronously resected double primary hepatic cancers - hepatocellular carcinoma and cholangiolocellular carcinoma. ( 17139434 )
2006
39
Clinicopathologic study on cholangiolocellular carcinoma. ( 11182037 )
2001
40
Cholangiolocellular carcinoma of the liver: CT and MR findings. ( 11045707 )
2000
41
Hepatic recurrence of cholangiolocellular carcinoma: report of a case. ( 8884337 )
1996
42
CHOLANGIOLOCELLULAR CARCINOMA OF THE LIVER. ( 14207070 )
1964
43
Cholangiolocellular carcinoma of the liver. ( 13663020 )
1959

Variations for Cholangiolocellular Carcinoma

Expression for Cholangiolocellular Carcinoma

Search GEO for disease gene expression data for Cholangiolocellular Carcinoma.

Pathways for Cholangiolocellular Carcinoma

GO Terms for Cholangiolocellular Carcinoma

Cellular components related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 MUC1 ABCB1 PROM1

Molecular functions related to Cholangiolocellular Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity, coupled to transmembrane movement of substances GO:0042626 8.62 ABCB1 ABCC3

Sources for Cholangiolocellular Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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