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MCID: CHL066
MIFTS: 51

Cholangitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cholangitis

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MalaCards integrated aliases for Cholangitis:

Name: Cholangitis 12 56 45 15 74

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:9446
ICD9CM 36 576.1
MeSH 45 D002761
NCIt 51 C26718
SNOMED-CT 69 82403002
ICD10 34 K83.0
UMLS 74 C0008311
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Summaries for Cholangitis

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Disease Ontology : 12 A bile duct disease that is an inflammation of the bile duct.

MalaCards based summary : Cholangitis is related to sclerosing cholangitis, neonatal and suppurative cholangitis. An important gene associated with Cholangitis is CLDN1 (Claudin 1), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Vancomycin and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and colon, and related phenotypes are digestive/alimentary and homeostasis/metabolism

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Related Diseases for Cholangitis

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Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 519)
# Related Disease Score Top Affiliating Genes
1 sclerosing cholangitis, neonatal 34.4 CLDN1 DCDC2
2 suppurative cholangitis 33.3 ABCB4 CRP DLAT TNF
3 cholangitis, primary sclerosing 33.2 ABCB4 ALB CFTR DLAT FUT2 GGT1
4 sclerosing cholangitis 32.8 ABCB4 ALB CFTR CLDN1 DCDC2 FUT2
5 cholecystitis 32.4 ABCB4 ALB F2 GPT
6 cholelithiasis 32.1 ABCB4 ALB GPT NR1H4
7 autoimmune pancreatitis 31.2 CA2 CFTR HLA-DRB1
8 hepatitis 31.1 CLDN1 F2 GGT1 GPT TNF
9 autoimmune hepatitis 31.0 DLAT F2 GGT1 GPT HLA-DRB1
10 biliary atresia 30.9 ALB GPT NR1H4
11 acquired immunodeficiency syndrome 30.4 ALB IL6 TNF
12 choledocholithiasis 30.4 ABCB4 ALB ALPP F2 GPT
13 infantile liver failure syndrome 1 30.4 ALB F2 GPT
14 liver cirrhosis 30.4 ALB F2 GGT1 GPT
15 echinococcosis 30.3 HLA-DRB1 IL6 TNF
16 hepatitis c 30.3 CLDN1 GGT1 GPT TNF
17 portal hypertension 30.3 ALB F2 GPT TNF
18 bilirubin metabolic disorder 30.2 ALB F2 GGT1 GPT
19 graft-versus-host disease 30.2 HLA-DRB1 IL6 TNF
20 fascioliasis 30.0 ALB ALPP GPT
21 acute pancreatitis 29.9 CFTR CRP IL6
22 hepatitis e 29.9 ALB F2 GPT TNF
23 hepatitis a 29.9 ALB F2 GPT TNF
24 cholestasis 29.9 ABCB4 ALPP F2 GGT1 GPT NR1H4
25 acute liver failure 29.9 ALB F2 GPT
26 intussusception 29.9 CFTR CRP IL6
27 microscopic polyangiitis 29.9 HLA-DRB1 TNF
28 hepatitis b 29.8 ALB F2 GGT1 GPT TNF
29 angioimmunoblastic lymphadenopathy with dysproteinemia 29.8 IL6 TNF
30 kawasaki disease 29.6 ALB CRP IL6 TNF
31 cystitis 29.5 CRP IL6 TNF
32 psoriatic arthritis 29.5 CRP HLA-DRB1 IL6 TNF
33 purpura 29.4 CRP F2 IL6 TNF
34 meningitis 29.3 ALB CRP IL6 TNF
35 acute cystitis 29.3 ALB CRP IL6
36 acute pyelonephritis 29.3 ALB CRP IL6
37 gastroenteritis 29.3 ALB CRP FUT2 IL6 TNF
38 myeloma, multiple 29.2 ALB CRP IL6 TNF
39 chlamydia 29.2 CRP IL6 TNF
40 bronchiolitis 29.2 CRP IL6 TNF
41 bacterial infectious disease 29.1 CFTR CRP IL6 TNF
42 pyelonephritis 29.1 ALB CRP IL6 TNF
43 bacterial meningitis 29.1 ALB CRP IL6 TNF
44 liver disease 29.1 ABCB4 ALB ALPP DLAT F2 GGT1
45 leptospirosis 29.0 CRP F2 IL6 TNF
46 biliary tract disease 29.0 ABCB4 ALB CEACAM5 F2 GGT1 GPBAR1
47 peritonitis 28.8 ALB CRP F2 IL6 TNF
48 bile duct disease 28.8 ABCB4 ALB CEACAM5 F2 GGT1 GPBAR1
49 systemic lupus erythematosus 28.8 ALB CRP F2 HLA-DRB1 IL6 TNF
50 heart disease 28.8 ALB CRP F2 IL6 TNF

Comorbidity relations with Cholangitis via Phenotypic Disease Network (PDN): (show all 16)


Acute Cystitis Acute Pancreatitis
Cholecystitis Cholestasis
Deficiency Anemia Familial Atrial Fibrillation
Gallbladder Cancer Heart Disease
Hepatitis Intrahepatic Gall Duct Cancer
Pancreatic Cancer Pancreatitis, Hereditary
Paralytic Ileus Postcholecystectomy Syndrome
Primary Biliary Cirrhosis Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Cholangitis:



Diseases related to Cholangitis
Sources

Symptoms & Phenotypes for Cholangitis

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MGI Mouse Phenotypes related to Cholangitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.97 ABCB4 ALB CA2 CFTR F2 FUT2
2 homeostasis/metabolism MP:0005376 9.93 ABCB4 ALB CA2 CFTR CLDN1 CRP
3 endocrine/exocrine gland MP:0005379 9.91 ABCB4 ALB CA2 CFTR GGT1 GPBAR1
4 immune system MP:0005387 9.7 ABCB4 CA2 CFTR CRP F2 FUT2
5 liver/biliary system MP:0005370 9.17 ABCB4 ALB CFTR GPBAR1 IL6 NR1H4
Sources

Drugs & Therapeutics for Cholangitis

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Drugs for Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 251)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1404-90-6 14969 441141
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
4
Cefotaxime Approved Phase 4,Not Applicable 63527-52-6 5742673 456256
5
Cefoxitin Approved Phase 4,Not Applicable 35607-66-0 441199
6
Azithromycin Approved Phase 4 83905-01-5 447043 55185
7
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
8
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
9
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
10
Metronidazole Approved Phase 4,Phase 1,Not Applicable 443-48-1 4173
11
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
12
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 6473866 445643 439492
13
Prednisone Approved, Vet_approved Phase 4,Not Applicable 53-03-2 5865
14
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2 24280-93-1 446541
15
Prednisolone phosphate Approved, Vet_approved Phase 4,Not Applicable 302-25-0
16
Methylprednisolone hemisuccinate Approved Phase 4,Not Applicable 2921-57-5
17
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
18
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
19
Ceftriaxone Approved Phase 4,Phase 2 73384-59-5 5479530 5361919
20
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 128-13-2 31401
21
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2 474-25-9 10133
22
Ofloxacin Approved Phase 4 82419-36-1 4583
23
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
24
Temocillin Approved, Investigational Phase 4 66148-78-5
25
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
26
Palonosetron Approved, Investigational Phase 4 135729-61-2, 135729-56-5, 119904-90-4 148211
27
Fosaprepitant Approved Phase 4 172673-20-0 219090
28
Prednisolone hemisuccinate Experimental Phase 4,Not Applicable 2920-86-7
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Amoxicillin-Potassium Clavulanate Combination Phase 4
32 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
33 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Clavulanic Acids Phase 4
35 Adrenergic Agonists Phase 4,Not Applicable
36 Bronchodilator Agents Phase 4,Phase 1,Not Applicable
37 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
38 Adrenergic beta-Agonists Phase 4,Not Applicable
39 Respiratory System Agents Phase 4,Phase 2,Phase 1,Not Applicable
40 Vasoconstrictor Agents Phase 4,Phase 2,Not Applicable
41 Autonomic Agents Phase 4,Phase 1,Not Applicable
42 Epinephryl borate Phase 4,Not Applicable
43 Mydriatics Phase 4,Not Applicable
44 Adrenergic Agents Phase 4,Not Applicable
45 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2,Not Applicable
46 Anti-Asthmatic Agents Phase 4,Phase 1,Not Applicable
47 Sympathomimetics Phase 4,Not Applicable
48 Adrenergic alpha-Agonists Phase 4,Not Applicable
49 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Hormone Antagonists Phase 4,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 283)
# Name Status NCT ID Phase Drugs
1 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
2 Randomised Trial Comparing Metal and Plastic Biliary Stents Stents for Palliating Malignant Jaundice Unknown status NCT00731419 Phase 4
3 Empirical vs 2nd Line Antibiotic Therapy in Health-care Associated Infections in Cirrhosis Unknown status NCT01820026 Phase 4 Imipenem;Vancomycin;azithromycin;Cefotaxime;Amoxicillin
4 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
5 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
6 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
7 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
8 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
9 RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction Completed NCT00980889 Phase 4
10 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
11 A Study of CellCept (Mycophenolate Mofetil) in Combination Therapy in Liver Transplant Patients. Completed NCT00545402 Phase 4 Mycophenolate mofetil, adjusted dose;Tacrolimus;Corticosteroids, IV;Mycophenolate mofetil, Standard dose;Corticosteroids, PO
12 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
13 Leflunomide for Maintenance of Remission in IgG4 Related Disease Completed NCT02703194 Phase 4 Prednisone;Leflunomide
14 Antibiotics to Decrease Post ERCP Cholangitis Recruiting NCT03087656 Phase 4 Ceftriaxone;Levofloxacin
15 A Trial of 18-22mg/kg/d Ursodeoxycholic in Refractory Primary Biliary Cholangitis Recruiting NCT03345589 Phase 4 18-22mg/kg/d Ursodeoxycholic;13-15mg/kg/d Ursodeoxycholic
16 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
17 Study of OCA Evaluating Pharmacokinetics and Safety in Patients With PBC and Hepatic Impairment Recruiting NCT03633227 Phase 4 Obeticholic Acid (OCA);Placebo
18 Temocillin Pharmacokinetics in Paediatrics Recruiting NCT02260102 Phase 4 Temocillin
19 PALONOSETRON X FOSAPREPITANT IN PONV Recruiting NCT03586817 Phase 4 Palonosetron;Fosaprepitant
20 The INFECIR-2 Albumin Prevention Study Terminated NCT02034279 Phase 4 Albumin
21 Short-term Stenting Versus Balloon Dilatation for Dominant Strictures in Primary Sclerosing Cholangitis Unknown status NCT01398917 Phase 3
22 Probiotics in Patients With Primary Sclerosing Cholangitis Unknown status NCT00161148 Phase 3 Probiotics
23 The Effect of Bezafibrate on Cholestatic Itch Unknown status NCT02701166 Phase 3 Bezafibrate;Placebo
24 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
25 Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects Completed NCT01802073 Phase 3 Oral Vancomycin
26 Trial of High-dose Urso in Primary Sclerosing Cholangitis Completed NCT00059202 Phase 2, Phase 3 Ursodeoxycholic Acid
27 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
28 Efficacy and Safety of Concentration-controlled Everolimus to Eliminate or to Reduce Tacrolimus Compared to Tacrolimus in de Novo Liver Transplant Recipients Completed NCT00622869 Phase 3 Tacrolimus (reduced tacrolimus);Tacrolimus (tacrolimus elimination);Tacrolimus (tacrolimus control);Everolimus (reduced tacrolimus);Everolimus (tacrolimus elimination);Corticosteroids
29 Extension Study to Evaluate the Long-term Efficacy and Safety of Everolimus in Liver Transplant Recipients Completed NCT01150097 Phase 3 Tacrolimus (reduced tacrolimus);Everolimus (reduced tacrolimus);Tacrolimus (tacrolimus elimination);Everolimus (tacrolimus elimination);Tacrolimus (tacrolimus control);Corticosteroids
30 Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis Completed NCT01473524 Phase 3 Obeticholic Acid (OCA);Placebo
31 A Clinical Trial to Assess the Efficacy and Safety of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-383) Completed NCT02550288 Phase 3 Ezetimibe 10 mg;Atorvastatin 10 mg;Placebo for Ezetimibe 10 mg tablet;Placebo for Atorvastatin 10 mg capsule
32 A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-384) Completed NCT02460159 Phase 3 EZ 10 mg/Atorva 20 mg FDC;EZ 10 mg/Atorva 10 mg FDC
33 A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832) Completed NCT02741245 Phase 3 Ezetimibe 10 mg;Rosuvastatin 2.5 mg;Placebo for Ezetimibe;Placebo for Rosuvastatin
34 A National Multi-center Randomized, Open Label Study to Evaluate Efficacy and Safety of Everolimus With EC-MPS Compared to Standard Treatment Combination Tacrolimus and EC-MPS in de Novo Liver Transplant Recipients Completed NCT01625377 Phase 3 tacrolimus;everolimus;Basiliximab;Mycophenolic Acid;Corticosteroids
35 ENHANCE: Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Response to or an Intolerance to Ursodeoxycholic Acid (UDCA) Recruiting NCT03602560 Phase 3 seladelpar 5-10 mg;seladelpar 10 mg;Placebo
36 Safety, Tolerability, and Efficacy of Cilofexor in Non-Cirrhotic Adults With Primary Sclerosing Cholangitis (PSC-Phase 3) Recruiting NCT03890120 Phase 3 Cilofexor;Placebo
37 Vancomycin for Primary Sclerosing Cholangitis Recruiting NCT03710122 Phase 2, Phase 3 Vancomycin
38 Norursodeoxycholic Acid vs Placebo in PSC Recruiting NCT03872921 Phase 3 Norursocholic Acid
39 Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) Recruiting NCT03301506 Phase 2, Phase 3 Seladelpar 2 mg Capsule;Seladelpar 5 mg Capsule;Seladelpar 10 mg Capsule
40 Use of Bezafibrate in Patients With Primary Biliary Cirrhosis to Archive Complete Biochemical Response in Non-responders Recruiting NCT02937012 Phase 3 Bezafibrate;Ursodeoxycholic Acid;Placebo (for Bezafibrate)
41 Kaffes Stent in the Management of Post-surgical Biliary Strictures Recruiting NCT03716232 Phase 3
42 Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation Recruiting NCT02584283 Phase 3 Glutathione
43 A Randomized Phase III Trial Comparing Folfirinox to Gemcitabine in Locally Advanced Pancreatic Carcinoma Recruiting NCT02539537 Phase 3 Gemcitabine;Folinic Acid;5-Fluoro-uracil;Oxaliplatin;Irinotecan;L-folinic
44 Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After Curative Intent Resection of Biliary Tract Cancer Recruiting NCT02170090 Phase 3 Gemcitabine;Cisplatin;Capecitabine
45 Remaxol® in Malignant Mechanical Jaundice Recruiting NCT03416062 Phase 3 Remaxol®;Ringer's Solution
46 Remaxol® in Mechanical Jaundice of Non-malignant Origin Recruiting NCT03418935 Phase 3 Remaxol (succinate + methionine + inosine + nicotinamide);Ringer's Solution
47 Efficacy and Safety of Vedolizumab Intravenous (IV) in the Treatment of Primary Sclerosing Cholangitis in Subjects With Underlying Inflammatory Bowel Disease Withdrawn NCT03035058 Phase 3 Vedolizumab;Placebo
48 Role of Endoscopic RFA in Prolonging the Patency of Metal Stents in Patients With Malignant Obstructive Jaundice Unknown status NCT01275768 Phase 1, Phase 2
49 Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis Unknown status NCT01690845 Phase 2
50 PERSEUS: Preliminary Efficacy and Safety of Cenicriviroc in Adult Participants With Primary Sclerosing Cholangitis Completed NCT02653625 Phase 2 Cenicriviroc 150 mg

Search NIH Clinical Center for Cholangitis

Cochrane evidence based reviews: cholangitis

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Genetic Tests for Cholangitis

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Anatomical Context for Cholangitis

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MalaCards organs/tissues related to Cholangitis:

42
Liver, T Cells, Colon, Bone, Neutrophil, Pancreas, Kidney
Sources

Publications for Cholangitis

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Articles related to Cholangitis:

(show top 50) (show all 4216)
# Title Authors Year
1
Acute cholangitis secondary to hydatid membranes in the biliary tract. ( 30176226 )
2019
2
Endoscopic Retrograde Cholangio-Pancreatography-Obtained Bile Culture Can Guide Antibiotic Therapy in Acute Cholangitis. ( 30282078 )
2019
3
Short-Course Antibiotic Treatment Is Not Inferior to a Long-Course One in Acute Cholangitis: A Systematic Review. ( 30368681 )
2019
4
Acute Cholangitis with Atypical Clinical Presentation and Imaging. ( 30392151 )
2019
5
Efficacy of Combined Thrombomodulin and Antithrombin in Anticoagulant Therapy for Acute Cholangitis-induced Disseminated Intravascular Coagulation. ( 30449812 )
2019
6
Saccharomyces cerevisiae fungemia in a critically ill patient with acute cholangitis and long term probiotic use. ( 30505677 )
2019
7
Efficacy and safety of early cholecystectomy for comorbid acute cholecystitis and acute cholangitis: Retrospective cohort study. ( 30581570 )
2019
8
Early vs late endoscopic retrograde cholangiopancreatography in patients with acute cholangitis: A nationwide analysis. ( 30705731 )
2019
9
Upper gastrointestinal hemorrhage is associated with poor outcomes among patients with acute cholangitis: a nationwide analysis. ( 30741727 )
2019
10
Unchanged mortality in patients with acute cholangitis despite an increase in malignant etiologies - a 25-year epidemiological study. ( 30946608 )
2019
11
"Primary bacterial culture of bile and pancreatic juice in tumor related jaundice (TROJ) - is ascending cholangitis always our fault?" ( 30621478 )
2019
12
Increase trend in the prevalence and male-to-female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan. ( 30932290 )
2019
13
Treatment response in primary biliary cholangitis: The role of autoimmune hepatitis features. ( 31036497 )
2019
14
Autoimmune liver disease (primary biliary cholangitis/autoimmune hepatitis-overlap) associated with sarcoidosis (clinical cases and literature review). ( 31090378 )
2019
15
Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018). ( 31094167 )
2019
16
IgG4 related autoimmune pancreatitis and sclerosing cholangitis. ( 30457561 )
2019
17
Case of IgG4-associated sclerosing cholangitis with normal serum IgG4 concentration, diagnosed by anti-laminin 511-E8 antibody: a novel autoantibody in patients with autoimmune pancreatitis. ( 30760486 )
2019
18
A Curious Case of Autoimmune Pancreatitis with IgG4-related Sclerosing Cholangitis. ( 31058036 )
2019
19
Massive hemobilia following plastic stent removal in common bile duct cancer associated with primary sclerosing cholangitis (with video). ( 30056613 )
2019
20
Biliary Atresia Associated Cholangitis - The Central Role and Effective Management of Bile Lakes. ( 30628982 )
2019
21
Longitudinal analysis of CA19-9 reveals individualised normal range and early changes before development of biliary tract cancer in patients with primary sclerosing cholangitis. ( 30687954 )
2019
22
Caroli Disease Revisited: A Case of a Kidney Transplant Patient With Autosomal Polycystic Kidney Disease and Recurrent Episodes of Cholangitis. ( 30879585 )
2019
23
Cholangitis mimicking hilar cholangiocarcinoma. ( 31014751 )
2019
24
Postbiliary drainage rates of cholangitis are impacted by procedural technique for patients with supra-ampullary cholangiocarcinoma: A SEER-Medicare analysis. ( 31044430 )
2019
25
Cholangiocarcinoma is associated with a raised enhanced liver fibrosis (ELF) score independent of primary sclerosing cholangitis. ( 30762236 )
2019
26
Is recurrent pyogenic cholangitis an independent poor prognostic indicator for resectable intrahepatic cholangiocarcinoma? ( 30274881 )
2019
27
Increased Cthrc1 expression in primary biliary cholangitis. ( 31102333 )
2019
28
Chronic Hepatitis E is associated with Cholangitis. ( 31102493 )
2019
29
Invasive Hepatobiliary Trichosporon asahii Infection in a Child With Autoimmune Cholangitis. ( 31107957 )
2019
30
Return to sender: Lymphocyte trafficking mechanisms as contributors to primary sclerosing cholangitis. ( 31108158 )
2019
31
The extrahepatic events of Asian patients with primary biliary cholangitis: A 30-year cohort study. ( 31110209 )
2019
32
Immunoglobulin G4-related sclerosing cholangitis: A review. ( 31112324 )
2019
33
Ten-Year Experience in the Prevention of Post-Kasai Cholangitis. ( 30657432 )
2019
34
The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis. ( 30661255 )
2019
35
A pilot study of fecal bile acid and microbiota profiles in inflammatory bowel disease and primary sclerosing cholangitis. ( 30666146 )
2019
36
Hepatology Elsewhere. ( 30672600 )
2019
37
Baveno-VI-Guided Prediction of Esogastric Varices in Primary Biliary Cholangitis. ( 30676377 )
2019
38
Editorial: liver transplantation for primary biliary cholangitis-the need for timely and more effective treatments. Authors' reply. ( 30689255 )
2019
39
Editorial: liver transplantation for primary biliary cholangitis-the need for timely and more effective treatments. ( 30689256 )
2019
40
CD4+ T cells from patients with primary biliary cholangitis show T cell activation and differentially expressed T-cell receptor repertoires. ( 30690835 )
2019
41
Specific Features of Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis. ( 30700999 )
2019
42
Treatment of primary sclerosing cholangitis in children. ( 30705716 )
2019
43
Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker? ( 30709684 )
2019
44
Severe hypocalcemia following denosumab treatment in a patient with secondary osteoporosis associated with primary sclerosing cholangitis. ( 30713246 )
2019
45
TCRβ repertoire of memory T cell reveals potential role for Escherichia coli in the pathogenesis of primary biliary cholangitis. ( 30721553 )
2019
46
Monitoring of impaired phagocytic function of Kupffer cells in an obstructive cholangitis rat model using superparamagnetic iron oxide MRI and contrast-enhanced ultrasound. ( 30724596 )
2019
47
Primary Sclerosing Cholangitis: A Concise Review of Diagnosis and Management. ( 30725292 )
2019
48
Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial. ( 30730351 )
2019
49
In vivo 1 H MRS of human gallbladder bile in understanding the pathophysiology of primary sclerosing cholangitis (PSC): Immune-mediated disease versus bile acid-induced injury. ( 30735273 )
2019
50
Primary biliary cholangitis patients exhibit MRI changes in structure and function of interoceptive brain regions. ( 30735529 )
2019
Sources

Variations for Cholangitis

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Expression for Cholangitis

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Search GEO for disease gene expression data for Cholangitis.
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Pathways for Cholangitis

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Pathways related to Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.75 ALB ALPP CFTR IL6
2
Hematopoietic cell lineage 38
11.62 HLA-DRB1 IL6 TNF
3
Rheumatoid arthritis 38
11.54 HLA-DRB1 IL6 TNF
4
Selenium Micronutrient Network 1
Show member pathways
 11.43 ALB CRP F2 GGT1 IL6 TNF
5
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.2 CA2 IL6 TNF
6
Bile secretion 38
11.11 ABCB4 CA2 CFTR NR1H4
7
Cytokines and Inflammatory Response 1
10.9 HLA-DRB1 IL6 TNF
8
Overview of nanoparticle effects 1
10.61 CRP IL6 TNF
9
RXR and RAR heterodimerization with other nuclear receptor 1
10.58 NR1H4 TNF
Sources

GO Terms for Cholangitis

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Cellular components related to Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 ALB CA2 CRP F2 GGT1 GPT
2 extracellular exosome GO:0070062 9.28 ABCB4 ALB CA2 CEACAM5 F2 FUT2

Biological processes related to Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.5 CRP IL6 TNF
2 acute-phase response GO:0006953 9.33 CRP F2 IL6
3 positive regulation of neuroinflammatory response GO:0150078 9.26 IL6 TNF
4 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.13 CFTR HLA-DRB1 NR1H4
5 negative regulation of lipid storage GO:0010888 8.8 CRP IL6 TNF

Molecular functions related to Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bile acid receptor activity GO:0038181 8.62 GPBAR1 NR1H4
Sources

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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