MCID: CHL067
MIFTS: 59

Cholecystitis

Categories: Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Cholecystitis

MalaCards integrated aliases for Cholecystitis:

Name: Cholecystitis 12 73 20 54 44 15 70 32
Acute Cholecystitis 12 54 15 70 32
Chronic Cholecystitis 12 54 70 32
Acute and Chronic Cholecystitis 12 70
Acalculous Cholecystitis 20 70
Gallstone Cholecystitis 20 6
Calculus of Gallbladder with Cholecystitis 70
Acute on Chronic Cholecystitis 12
Cholecystitis, Acute 17

Classifications:



External Ids:

Disease Ontology 12 DOID:1949
ICD9CM 34 575.10
MeSH 44 D002764
NCIt 50 C34465
SNOMED-CT 67 76581006
UMLS 70 C0008325 C0085694 C0149520 more

Summaries for Cholecystitis

Disease Ontology : 12 A cholangitis that is characterized by an inflammation that is located in the gallbladder.

MalaCards based summary : Cholecystitis, also known as acute cholecystitis, is related to emphysematous cholecystitis and acalculous cholecystitis. An important gene associated with Cholecystitis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Endometrial cancer and Gastric cancer. The drugs Ketamine and Nefopam have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and kidney, and related phenotypes are cellular and digestive/alimentary

Wikipedia : 73 Cholecystitis is inflammation of the gallbladder. Symptoms include right upper abdominal pain, nausea,... more...

Related Diseases for Cholecystitis

Diseases related to Cholecystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 897)
# Related Disease Score Top Affiliating Genes
1 emphysematous cholecystitis 32.9 GPT F2
2 acalculous cholecystitis 32.5 GPT F2 CCKAR CCK ALB
3 pleural empyema 31.4 GPT F2 ALB
4 gallbladder disease 31.2 TP53 GPT EGFR CDH1 CCKAR CCK
5 cholelithiasis 31.1 HP GPT CCKAR CCK ALB ABCB4
6 obstructive jaundice 31.0 TLR4 GPT F2 ALB
7 acute pancreatitis 31.0 TLR4 GPT CCKAR CCK
8 choledocholithiasis 30.9 GPT F2 CCK ALB ABCB4
9 cholecystolithiasis 30.9 GPT CCK ABCB4
10 typhoid fever 30.9 TLR4 GPT F2 ALB
11 ileus 30.9 F2 CCK CALCA
12 cholangitis 30.8 TLR4 HP GPT F2 ALB ABCB4
13 hepatitis a 30.7 TLR4 GPT F2 ALB
14 exanthem 30.6 GPT F2 EGFR ALB
15 gastritis 30.6 TP53 TLR4 MUC6 CDH1
16 acute cholangitis 30.6 MUC5AC MUC1 GPT F2 CALCA ALB
17 cholestasis 30.6 GPT F2 CCK ALB ABCB4
18 gallbladder cancer 30.5 TP53 MUC1 EGFR EGF CDKN2A CDH1
19 acute kidney failure 30.5 HP GPT F2 EGF ALB
20 pyelonephritis 30.5 TLR4 GPT CALCA ALB
21 ascending cholangitis 30.4 GPT F2 ALB
22 gastric ulcer 30.4 TP53 EGF CALCA
23 viral hepatitis 30.4 TLR4 KRT18 GPT F2 ALB
24 cystitis 30.4 TP53 TLR4 EGF CDH1
25 aspiration pneumonia 30.3 GPT F2 ALB
26 respiratory failure 30.3 TLR4 MUC5AC GPT F2 ALB
27 cholangitis, primary sclerosing 30.3 GPT F2 ALB ABCB4
28 pericardial effusion 30.3 GPT F2 ALB
29 schistosomiasis 30.3 TP53 GPT F2 ALB
30 gastroenteritis 30.3 CDH1 CALCA ALB
31 paralytic ileus 30.3 GPT F2 ALB
32 intrahepatic cholangiocarcinoma 30.3 TP53 MUC5AC MUC1 EGFR CDH1 ALB
33 salmonellosis 30.2 TLR4 GPT ALB
34 hepatorenal syndrome 30.2 GPT F2 ALB
35 vascular disease 30.2 TP53 TLR4 HP F2 ALB
36 bilirubin metabolic disorder 30.2 HP GPT F2 ALB ABCB4
37 dengue hemorrhagic fever 30.2 GPT F2 ALB
38 hepatic infarction 30.1 GPT F2 ALB
39 hepatic coma 30.1 GPT F2 ALB
40 splenic infarction 30.1 GPT F2 ALB
41 bile duct cysts 30.1 GPT ALB ABCB4
42 hemosiderosis 30.1 HP GPT ALB
43 cellulitis 30.1 GPT F2 ALB
44 constipation 30.1 GPT CCK CALCA ALB
45 dysentery 30.1 HP GPT ALB
46 portal hypertension 30.1 TLR4 GPT F2 ALB
47 hepatitis e 30.1 GPT F2 ALB
48 papillary adenocarcinoma 30.1 TP53 MUC1 CDH1
49 atrophic gastritis 30.1 TP53 MUC6 EGF
50 hydrops of gallbladder 30.0 GPT ALB

Comorbidity relations with Cholecystitis via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Acute Pancreatitis
Cholangitis Cholestasis
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Cholecystitis:



Diseases related to Cholecystitis

Symptoms & Phenotypes for Cholecystitis

MGI Mouse Phenotypes related to Cholecystitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 ABCB4 ALB CCKAR CDH1 CDKN2A DAPK1
2 digestive/alimentary MP:0005381 10.18 ABCB4 ALB CCKAR CDH1 CDKN2A EGF
3 homeostasis/metabolism MP:0005376 10.17 ABCB4 ALB CCK CCKAR CDH1 CDKN2A
4 endocrine/exocrine gland MP:0005379 10.11 ABCB4 ALB CCK CCKAR CDH1 CDKN2A
5 immune system MP:0005387 10.07 ABCB4 ALB CCK CDH1 CDKN2A EGF
6 liver/biliary system MP:0005370 9.85 ABCB4 ALB CCKAR CDKN2A EGFR HP
7 neoplasm MP:0002006 9.61 ABCB4 ALB CDH1 CDKN2A EGFR HP
8 renal/urinary system MP:0005367 9.23 ALB CCK CCKAR DAPK1 EGFR HP

Drugs & Therapeutics for Cholecystitis

Drugs for Cholecystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 123)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2
Nefopam Approved, Investigational Phase 4 13669-70-0
3
Metronidazole Approved Phase 4 443-48-1 4173
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
7
Tigecycline Approved Phase 4 220620-09-7 5282044
8
Remifentanil Approved Phase 4 132875-61-7 60815
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
10
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
11
tannic acid Approved Phase 4 1401-55-4
12
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
13
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
14
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
15
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
16
Sultamicillin Approved, Investigational Phase 4 76497-13-7
17
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
18 Hemostatics Phase 4
19 Anesthetics, Intravenous Phase 4
20 Anesthetics, Dissociative Phase 4
21 Excitatory Amino Acid Antagonists Phase 4
22 Anti-Bacterial Agents Phase 4
23 Anti-Infective Agents Phase 4
24 Micronutrients Phase 4
25 Trace Elements Phase 4
26 Nutrients Phase 4
27 Antioxidants Phase 4
28 Vitamins Phase 4
29 Protective Agents Phase 4
30 Antiprotozoal Agents Phase 4
31 Antiparasitic Agents Phase 4
32 Neurotransmitter Agents Phase 4
33 Adrenergic alpha-Agonists Phase 4
34 Adrenergic Agonists Phase 4
35 Hypnotics and Sedatives Phase 4
36 Adrenergic Agents Phase 4
37 Neuromuscular Nondepolarizing Agents Phase 4
38 Neuromuscular Blocking Agents Phase 4
39 Antirheumatic Agents Phase 4
40 Cyclooxygenase Inhibitors Phase 4
41 Cyclooxygenase 2 Inhibitors Phase 4
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4
43 Antibiotics, Antitubercular Phase 4
44
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
45
Promethazine Approved, Investigational Phase 3 60-87-7 4927
46
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
47
Tazobactam Approved Phase 3 89786-04-9 123630
48
Piperacillin Approved Phase 3 66258-76-2 43672
49
Doripenem Approved, Investigational Phase 3 148016-81-3 73303
50
Bupivacaine Approved, Investigational Phase 3 38396-39-3, 2180-92-9 2474

Interventional clinical trials:

(show top 50) (show all 167)
# Name Status NCT ID Phase Drugs
1 THE USE OF FLOSEAL GELATIN MATRIX FOR THE HAEMOSTASIS DURING LAPAROSCOPIC CHOLECYSTECTOMY FOR ACUTE CHOLECYSTITIS; EFFICACY AND SAFETY EVALUATED IN A MULTICENTER, PROSPECTIVE, OPEN LABEL TRIAL WITH AN HISTORICAL CONTROL GROUP. (G.L.A. STUDY: GELATIN Matrix in Laparoscopic Cholecystectomy for Acute Cholecystitis) Unknown status NCT01126281 Phase 4
2 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
3 The Role of a Single Oral Dose (2g) of Vitamin C in Reducing Intensity of Pain and Opioids Consumption in Patients Undergoing Laparoscopic Cholecystectomy. A Randomized, Double-blinded, Placebo-controlled Study Completed NCT01322061 Phase 4 Ascorbic Acid
4 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy Due to Acute Cholecystitis. Is it Necessary? Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
5 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
6 Opioid-free Total Intravenous Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy; Comparison With Propofol, Remifentanil Infusions Completed NCT01833819 Phase 4 Dexmedetomidine and lidocaine;Remifentanil
7 Effect of Deep Versus Moderate Neuromuscular Blockade on Peak Airway Pressures During Elective Laparoscopic Surgery Completed NCT02812186 Phase 4 Rocuronium
8 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
9 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Randomized Multi-center Study Completed NCT01744847 Phase 4
10 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
11 Role of Indocyanine Green in Visualizing Critical View of Safety During Laparoscopic Cholecystectomy for Acute Cholecystitis Not yet recruiting NCT04624841 Phase 4 Indocyanine Green
12 Is an Antibiotic Prescription Required After Laparoscopic Cholecystectomy for Acute Calculous Cholecystitis? Not yet recruiting NCT04290104 Phase 4 1gr oral ampicillin/sulbactam group
13 Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
14 Drainage is Not Necessary Procedure After Laparoscopic Cholecystectomy Due to Severe Acute Cholecystitis Unknown status NCT01625247 Phase 3
15 Prospective Study for the Effects of Biphenyl Dimethyl Dicarboxylate and Ursodeoxycolic Acid Therapy on Liver Function and Quality of Life After Laparoscopic Cholecystectomy Unknown status NCT03578055 Phase 3 BDD with UDCA;Placebo
16 Single Port Access Cholecystectomy Versus Standard Laparoscopic Cholecystectomy - Randomized Study Unknown status NCT00904865 Phase 2, Phase 3
17 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy = ACDC-study Completed NCT00447304 Phase 3 moxifloxacin
18 Piperacllin Versus Placebo in Patients Undergoing Surgery for Acute Cholecystitis Completed NCT02619149 Phase 3 Piperacillin-tazobactam combination product;Saline solution
19 Endosonography-guided Gallbladder Drainage (EGBD) Versus Percutaneous Cholecystostomy (PC) in Patients Suffering From Acute Cholecystitis That Are Unsuitable for Surgery. A Randomized Controlled Trial. Completed NCT02212717 Phase 2, Phase 3
20 Antibiotic Treatment Versus no Antibiotics in the Postoperative Acute Cholecystitis Low and Moderately Severe Completed NCT01015417 Phase 3 Amoxicillin clavulanic acid
21 A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
22 A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
23 An Expertise-based Randomized Controlled Trial Comparing Minilaparotomy Cholecystectomy and Laparoscopic Cholecystectomy Completed NCT00370344 Phase 2, Phase 3
24 Bakirkoy Dr. Sadi Konuk Training and Research Hospital Not yet recruiting NCT04767542 Phase 3 Intravenous Infusion
25 Efficacy of Preoperative Injection of Naldebain® in Management of Acute and Chronic Pain After Laparoscopic Cholecystectomy Not yet recruiting NCT04808544 Phase 2, Phase 3 Dinalbuphine sebacate;Placebo solution
26 Does it Make Sense to Give Postoperative Antibiotics to Patients With an Uncomplicated Acute Cholecystitis Completed NCT00323648 Phase 2 Whether or not giving postoperatively antibiotics to patients with an uncomplicated acute cholecystitis
27 Efficacy of Intraperitoneal Ondansetron Administration on Pain Relief After Laparoscopic Cholecystectomy Completed NCT04468685 Phase 2 Ondansetron;Normal saline
28 Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy Sub-Study Completed NCT02070627 Phase 1 Indocyanine Green (ICG)
29 Prospective Randomized Control Study of Clinical Effectiveness of Prophylactic Antibiotics Therapy in Laparoscopic Cholecystectomy on Infection Rate Completed NCT04726046 Phase 1 Cefotetan
30 Laparoscopic Cholecystectomy Using Transvaginal Endoscopic Assistance Withdrawn NCT00815438 Phase 1
31 Acute Cholecystitis: Early Versus Delayed Laparoscopic Cholecystectomy; Randomized Prospective Study Unknown status NCT02130245
32 Percutaneous Drainage in a Setting of Acute Cholecystitis Severity Grade III and Correlation With Clinical Outcomes Unknown status NCT03087747
33 Laparoscopic Cholecystectomy for Management of Acute Calculous Cholecystitis Within and After 3 Days of Disease Onset Unknown status NCT03477253
34 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
35 Prediction of Postoperative Pain by Injection Pain of Propofol Unknown status NCT03021447
36 Intra-gallbladder or Systemic Indocyanide Green Injection Facilitate Cholecystectomy in Acute Cholecystitis , Gallstone and Gallbladder Polyp Patients. Unknown status NCT03024892
37 Effect of Vitamin C on Postoperative Pain After Laparoscopic Cholecystectomy; a A Prospective Randomized Controlled Trial Unknown status NCT02553551 Vitamin C;Placebo
38 Assessment of Routine Use of Critical View of Safety in Laparoscopic Cholecystectomy, Prospective Cohort Study Unknown status NCT03696823
39 Ultrasound First Clinical Decision Support for Suspected Nephrolithiasis Unknown status NCT03461536
40 Role of Abdominal Drainage for Laparoscopic Cholecystectomy a Prospective Randomised Study Unknown status NCT03909360
41 Evaluation of PC 6 "Neiguan" With Conventional Acupuncture to Prevent PONV After Laparoscopic Cholecystectomy. Unknown status NCT03088696
42 Near-infrared Fluorescence Cholangiography Assisted Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy (FALCON): a Multicenter Randomized Controlled Trial Unknown status NCT02558556
43 Proficiency-based Versus Free Laparoscopic Training in Cholecystectomy Using the Simbionix LAP Mentor™. A Randomized Controlled Trial Unknown status NCT01615549
44 Role of the Right Portal Pedicle and Rouviere's Sulcus as an Anatomic Landmark in Laparoscopic Cholecystectomy in Chinese Population Unknown status NCT02133027
45 Multicenter Cohort Study: To Explore the Standard Surgical Indication in Gallbladder Benign Disease Unknown status NCT02951169
46 Randomized, Double-blind, Controlled Trial of Harmonic(H) Versus Monopolar Diathermy (M) for Laparoscopic Cholecystectomy (LC) for Acute Cholecystitis (AC) in Adults. Completed NCT00746850
47 When Results of Randomised Controlled Trials and Population Based Studies do Not Reflect the Real World: A Cohort Study in Acute Cholecystitis Completed NCT02796443
48 Prophylactic Endoscopic Ultrasound Gallbladder Drainage (EUS-GBD) in Patients With Unresectable Malignant Biliary Obstruction and Cystic Duct Orifice Involvement. Completed NCT03729882
49 Accuracy of Functional MRC With Gadoxetate Disodium in the Diagnosis of Acute Cholecystitis: Comparison With Hepatobiliary Scintigraphy Completed NCT02100358
50 Modified Enhanced Recovery Program in Patients With Acute Cholecystitis Undergoing Laparoscopic Cholecystectomy: Prospective Randomized Trial Completed NCT03754751

Search NIH Clinical Center for Cholecystitis

Cochrane evidence based reviews: cholecystitis

Genetic Tests for Cholecystitis

Anatomical Context for Cholecystitis

MalaCards organs/tissues related to Cholecystitis:

40
Pancreas, Liver, Kidney, Breast, Heart, Colon, Thyroid

Publications for Cholecystitis

Articles related to Cholecystitis:

(show top 50) (show all 14655)
# Title Authors PMID Year
1
Diagnosis of monogenic liver diseases in childhood by next-generation sequencing. 6
28776642 2018
2
Heterozygous ABCB4 mutations in children with cholestatic liver disease. 6
26153658 2016
3
Elevation of gamma-glutamyl transferase in adult: Should we think about progressive familiar intrahepatic cholestasis? 6
26699824 2016
4
Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4. 6
24806754 2014
5
Functional Characterization of ABCB4 Mutations Found in Low Phospholipid-Associated Cholelithiasis (LPAC). 6
24381502 2013
6
Clinical features and genotype-phenotype correlations in children with progressive familial intrahepatic cholestasis type 3 related to ABCB4 mutations. 6
21119540 2011
7
ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahepatic cholestasis of pregnancy. 6
19584064 2009
8
ABCB4 heterozygous gene mutations associated with fibrosing cholestatic liver disease in adults. 6
18482588 2008
9
Molecular characterization and structural implications of 25 new ABCB4 mutations in progressive familial intrahepatic cholestasis type 3 (PFIC3). 6
17726488 2007
10
Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy. 6
16890614 2006
11
Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. 6
15077010 2004
12
ABCB4 gene mutation-associated cholelithiasis in adults. 6
12891548 2003
13
MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. 6
11313316 2001
14
Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. 6
9419367 1998
15
Gallbladder carcinoma manifesting as acute cholecystitis: clinical and computed tomographic features. 61 54
19744453 2009
16
Acute transient hepatocellular injury in cholelithiasis and cholecystitis without evidence of choledocholithiasis. 61 54
19673021 2009
17
Usefulness of fatty meal-stimulated cholescintigraphy in the diagnosis and treatment of chronic acalculous cholecystitis. 61 54
19225936 2009
18
Liver enzyme elevation and normal pulmonary function in an adult with a declining forced expiratory volume in 1 second. 61 54
18534093 2008
19
Expression and functional pharmacology of the bradykinin B1 receptor in the normal and inflamed human gallbladder. 61 54
18182589 2008
20
Effect of sequential administration of an opioid and cholecystokinin on gallbladder ejection fraction: brief communication. 61 54
16954554 2006
21
Stimulation with fatty meal (Lipomul) to assess gallbladder emptying in children with chronic acalculous cholecystitis. 61 54
12883305 2003
22
Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro. 61 54
12851878 2003
23
Influence of cholecystitis state on pharmacological response to cholecystokinin of isolated human gallbladder with gallstones. 54 61
12772786 2003
24
Gallbladder ejection fraction: an accurate evaluation of symptomatic acalculous gallbladder disease. 61 54
12872903 2003
25
Mechanisms of impaired gallbladder contractile response in chronic acalculous cholecystitis. 54 61
12022997 2002
26
Cholecystokinin cholescintigraphy: victim of its own success? 54 61
10616884 1999
27
Chronic acalculous cholecystitis: reproduction of pain with cholecystokinin and relief of symptoms with cholecystectomy. 61 54
10388344 1999
28
The clinical utility of quantitative cholescintigraphy: the significance of gallbladder dysfunction. 61 54
9596151 1998
29
Acute cholecystitis in AIDS patients: correlation of Tc-99m hepatobiliary scintigraphy with histopathologic laboratory findings and CD4 counts. 61 54
9554194 1998
30
Pharmacologic intervention for the diagnosis of acute cholecystitis: cholecystokinin pretreatment or morphine, or both? 54 61
9098218 1997
31
Cholecystokinin and morphine pharmacological intervention during 99mTc-HIDA cholescintigraphy: a rational approach. 61 54
8623048 1996
32
Abnormal gallbladder nuclear ejection fraction predicts success of cholecystectomy in patients with biliary dyskinesia. 54 61
8273847 1993
33
Cholecystokinin cholescintigraphy: detection of abnormal gallbladder motor function in patients with chronic acalculous gallbladder disease. 54 61
1880571 1991
34
[The blood level of cobalamin as an indicator of the functional status of the liver in jaundice of different etiologies]. 54 61
1721943 1991
35
Chronic right upper quadrant pain without gallstones: does HIDA scan predict outcome after cholecystectomy? 54 61
2375327 1990
36
[Sonographic criteria of acute acalculous cholecystitis.Critical observation of the clinical records of sedated, ventilated and parenterally nourished patients]. 61 54
2121670 1990
37
Cholecystokinin sonography: lack of utility in diagnosis of acute acalculous cholecystitis. 54 61
2183285 1990
38
Diagnostic significance of the CT rim sign in cases of gangrenous cholecystitis. 61
33310404 2021
39
A Nationwide Survey Study on Medical Student Experience in Acute Care Surgery. 61
33429223 2021
40
COVID-19 and Novel Coronavirus Cholecystitis. 61
33405432 2021
41
Prospective validation of the bedside sonographic acute cholecystitis score in emergency department patients. 61
33429186 2021
42
Low-phospholipid-associated cholelithiasis syndrome: Prevalence, clinical features, and comorbidities. 61
33554096 2021
43
Role of percutaneous cholecystostomy in all-comers with acute cholecystitis according to current guidelines in a general surgical unit. 61
33058055 2021
44
Healthcare Disparities in the Management of Acute Cholecystitis: Impact of Race, Gender, and Socioeconomic Factors on Cholecystectomy vs Percutaneous Cholecystostomy. 61
33629232 2021
45
18F-FDG PET/CT in Hyalinized Cholecystitis. 61
32956109 2021
46
Comparison of EUS-guided endoscopic transpapillary and percutaneous gallbladder drainage for acute cholecystitis: a systematic review with network meta-analysis. 61
32987004 2021
47
Treatment of acute cholecystitis in high-risk surgical patients. Systematic review of the literature according to the levels of evidence. 61
33793158 2021
48
Postoperative Outcomes after Index vs Interval Cholecystectomy for Perforated Cholecystitis. 61
33482322 2021
49
Comparison of emergency cholecystectomy and delayed cholecystectomy after percutaneous transhepatic gallbladder drainage in patients with acute cholecystitis: a systematic review and meta-analysis. 61
33048340 2021
50
Frailty Predicts Morbidity and Mortality After Laparoscopic Cholecystectomy for Acute Cholecystitis: An ACS-NSQIP Cohort Analysis. 61
32212087 2021

Variations for Cholecystitis

ClinVar genetic disease variations for Cholecystitis:

6 (show all 12)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ABCB4 NM_000443.4(ABCB4):c.959C>T (p.Ser320Phe) SNV Pathogenic 13690 rs72552778 GRCh37: 7:87076396-87076396
GRCh38: 7:87447080-87447080
2 ABCB4 NM_000443.4(ABCB4):c.523A>G (p.Thr175Ala) SNV Pathogenic 13691 rs58238559 GRCh37: 7:87082273-87082273
GRCh38: 7:87452957-87452957
3 ABCB4 NM_000443.4(ABCB4):c.3481C>T (p.Pro1161Ser) SNV Pathogenic 13692 rs121918442 GRCh37: 7:87035609-87035609
GRCh38: 7:87406293-87406293
4 ABCB4 NM_000443.4(ABCB4):c.3136C>T (p.Arg1046Ter) SNV Pathogenic 587488 rs759202962 GRCh37: 7:87037496-87037496
GRCh38: 7:87408180-87408180
5 ABCB4 NM_000443.4(ABCB4):c.1633C>G (p.Arg545Gly) SNV Pathogenic 39841 rs397514620 GRCh37: 7:87069081-87069081
GRCh38: 7:87439765-87439765
6 ABCB4 NM_000443.4(ABCB4):c.1328_1329delinsCAA (p.Gln443fs) Indel Pathogenic 13693 rs387906528 GRCh37: 7:87072662-87072663
GRCh38: 7:87443346-87443347
7 ABCB4 NM_000443.4(ABCB4):c.2869C>T (p.Arg957Ter) SNV Likely pathogenic 13687 rs121918440 GRCh37: 7:87041264-87041264
GRCh38: 7:87411948-87411948
8 ABCB4 NM_000443.4(ABCB4):c.2932T>C (p.Ser978Pro) SNV Likely pathogenic 599183 rs1051861187 GRCh37: 7:87038701-87038701
GRCh38: 7:87409385-87409385
9 ABCB4 NM_000443.4(ABCB4):c.217C>G (p.Leu73Val) SNV Uncertain significance 374521 rs8187788 GRCh37: 7:87092143-87092143
GRCh38: 7:87462827-87462827
10 ABCB4 NM_000443.4(ABCB4):c.101C>T (p.Thr34Met) SNV Uncertain significance 196273 rs142794414 GRCh37: 7:87101971-87101971
GRCh38: 7:87472655-87472655
11 ABCB4 NM_000443.4(ABCB4):c.1769G>A (p.Arg590Gln) SNV Uncertain significance 13697 rs45575636 GRCh37: 7:87060844-87060844
GRCh38: 7:87431528-87431528
12 ABCB4 NM_000443.4(ABCB4):c.140G>A (p.Arg47Gln) SNV Uncertain significance 197144 rs372685632 GRCh37: 7:87092220-87092220
GRCh38: 7:87462904-87462904

Expression for Cholecystitis

Search GEO for disease gene expression data for Cholecystitis.

Pathways for Cholecystitis

Pathways related to Cholecystitis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 TP53 EGFR EGF CDKN2A CDH1
2
Show member pathways
12.61 TP53 EGFR EGF CDKN2A CDH1
3
Show member pathways
12.34 TP53 RASSF1 EGFR EGF CDKN2A CDH1
4 12.28 TP53 RASSF1 F2 EGFR EGF DAPK1
5
Show member pathways
12.27 TLR4 KRT18 EGFR CDH1
6
Show member pathways
12.15 MUC1 EGFR EGF CDH1
7
Show member pathways
12.07 TP53 MUC1 EGFR EGF CDH1
8 11.77 TP53 TLR4 EGFR EGF CDH1
9 11.75 TP53 EGFR EGF CDKN2A
10 11.39 TP53 EGFR CDKN2A
11 11.23 EGFR EGF CDH1
12 11.1 EGFR EGF CDH1
13 11.03 TP53 RASSF1 EGFR EGF DAPK1 CDKN2A
14 10.98 RASSF1 EGFR EGF
15 10.44 EGFR EGF
16 10.37 MUC6 CCK
17
Show member pathways
10.08 EGFR EGF

GO Terms for Cholecystitis

Cellular components related to Cholecystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.96 MUC5AC MUC1 KRT18 HP GPT F2
2 extracellular region GO:0005576 9.7 MUC6 MUC5AC MUC1 HP F2 EGFR
3 Golgi lumen GO:0005796 9.46 MUC6 MUC5AC MUC1 F2
4 extracellular space GO:0005615 9.4 MUC6 MUC5AC MUC1 KRT18 HP GPT

Biological processes related to Cholecystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.43 TP53 RASSF1 CDKN2A
2 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.16 TP53 MUC1
3 O-glycan processing GO:0016266 9.13 MUC6 MUC5AC MUC1
4 negative regulation of ERBB signaling pathway GO:1901185 8.62 EGFR EGF

Molecular functions related to Cholecystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.23 TP53 TLR4 RASSF1 EGFR DAPK1 CDH1
2 MDM2/MDM4 family protein binding GO:0097371 9.16 TP53 CDKN2A
3 p53 binding GO:0002039 9.13 TP53 MUC1 CDKN2A

Sources for Cholecystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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