MCID: CHL067
MIFTS: 60

Cholecystitis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Cholecystitis

MalaCards integrated aliases for Cholecystitis:

Name: Cholecystitis 12 75 53 29 55 6 44 15 72 33
Acute Cholecystitis 12 55 15 72 33
Chronic Cholecystitis 12 55 72 33
Acute and Chronic Cholecystitis 12 72
Acalculous Cholecystitis 53 72
Calculus of Gallbladder with Cholecystitis 72
Acute on Chronic Cholecystitis 12
Gallstone Cholecystitis 53
Cholecystitis, Acute 17

Classifications:



External Ids:

Disease Ontology 12 DOID:1949
ICD9CM 35 575.10
MeSH 44 D002764
NCIt 50 C34465
SNOMED-CT 68 76581006
UMLS 72 C0008325 C0085694 C0149520 more

Summaries for Cholecystitis

Disease Ontology : 12 A cholangitis that is characterized by an inflammation that is located in the gallbladder.

MalaCards based summary : Cholecystitis, also known as acute cholecystitis, is related to cholecystolithiasis and gallbladder disease. An important gene associated with Cholecystitis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Pathways in cancer and Bladder cancer. The drugs Nefopam and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and pancreas, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 75 Cholecystitis is inflammation of the gallbladder. Symptoms include right upper abdominal pain, nausea,... more...

Related Diseases for Cholecystitis

Diseases related to Cholecystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 746)
# Related Disease Score Top Affiliating Genes
1 cholecystolithiasis 33.3 CCK ABCB4
2 gallbladder disease 33.1 CCKAR CCK ABCB4
3 cholelithiasis 32.3 GPT CCKAR CCK ALB ABCB4
4 obstructive jaundice 31.3 GPT F2 ALB
5 choledocholithiasis 31.3 GPT F2 ALB ABCB4
6 cholestasis 31.2 GPT F2 ABCB4
7 hepatitis a 31.0 GPT F2 ALB
8 biliary tract disease 31.0 F2 CCK ALB ABCB4
9 cholangitis, primary sclerosing 30.9 GPT ALB ABCB4
10 cholangitis 30.9 HP GPT F2 ALB ABCB4
11 ascending cholangitis 30.6 F2 CCK ALB
12 gallbladder cancer 30.5 TP53 MUC1 CDKN2A CDH1
13 portal hypertension 30.5 GPT F2 ALB
14 intrahepatic cholangiocarcinoma 30.5 TP53 MUC1 CDH1
15 bilirubin metabolic disorder 30.4 HP GPT F2 ALB
16 liver cirrhosis 30.3 KRT18 GPT F2 ALB
17 hepatic coma 30.3 GPT F2 ALB
18 viral hepatitis 30.3 KRT18 GPT F2 ALB
19 hepatic encephalopathy 30.2 GPT F2 ALB
20 intestinal disease 30.2 TP53 CDH1 ALB
21 hellp syndrome 30.2 HP GPT F2
22 in situ carcinoma 30.1 TP53 CDKN2A CDH1
23 pancreas disease 30.1 TP53 CCK ALB
24 bladder disease 30.0 TP53 CDKN2A CDH1
25 acute liver failure 30.0 GPT F2 ALB
26 hepatitis e 30.0 GPT F2 ALB
27 papillary adenocarcinoma 30.0 TP53 MUC1 CDH1
28 signet ring cell adenocarcinoma 29.8 MUC6 MUC1 CDH1
29 adenocarcinoma 29.8 TP53 MUC1 CDKN2A CDH1
30 squamous cell papilloma 29.8 TP53 F2 CDKN2A
31 liver disease 29.6 KRT18 GPT F2 ALB ABCB4
32 bile duct disease 29.4 GPT F2 CCK ALB ABCB4
33 alcoholic hepatitis 29.3 KRT18 GPT F2 ALB
34 squamous cell carcinoma 29.0 TP53 MUC1 DAPK1 CDKN2A CDH1
35 esophageal cancer 28.8 TP53 MUC1 CDKN2A CDH1 ALB
36 clear cell renal cell carcinoma 28.6 TP53 RASSF1 MUC1 CDH1
37 pancreatic cancer 28.5 TP53 MUC1 CDKN2A CDH1 CCKAR CCK
38 small cell cancer of the lung 28.4 TP53 RASSF1 KRT18 CDKN2A
39 hepatocellular carcinoma 28.1 TP53 RASSF1 F2 CDKN2A CDH1 ALB
40 cervical cancer 27.9 TP53 RASSF1 DAPK1 CDKN2A CDH1
41 bladder cancer 27.9 TP53 RASSF1 KRT18 DAPK1 CDKN2A CDH1
42 gastrointestinal system disease 27.8 TP53 F2 CDKN2A CDH1 CCKAR CCK
43 cholangiocarcinoma 27.4 TP53 RASSF1 MUC1 KRT18 DAPK1 CDKN2A
44 emphysematous cholecystitis 12.7
45 acalculous cholecystitis 12.6
46 xanthogranulomatous cholecystitis 12.5
47 gallbladder disease 1 12.1
48 opisthorchiasis 11.5
49 duodenal atresia 11.5
50 dicrocoeliasis 11.2

Comorbidity relations with Cholecystitis via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Acute Pancreatitis
Cholangitis Cholestasis
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Cholecystitis:



Diseases related to Cholecystitis

Symptoms & Phenotypes for Cholecystitis

MGI Mouse Phenotypes related to Cholecystitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 ABCB4 ALB CCKAR CDH1 CDKN2A DAPK1
2 homeostasis/metabolism MP:0005376 10 ABCB4 ALB CCK CCKAR CDH1 CDKN2A
3 digestive/alimentary MP:0005381 9.97 ABCB4 ALB CCKAR CDH1 CDKN2A F2
4 endocrine/exocrine gland MP:0005379 9.92 ABCB4 ALB CCK CCKAR CDH1 CDKN2A
5 liver/biliary system MP:0005370 9.76 ABCB4 ALB CCKAR CDKN2A HP KRT18
6 neoplasm MP:0002006 9.5 ABCB4 ALB CDH1 CDKN2A HP RASSF1
7 renal/urinary system MP:0005367 9.1 ALB CCK CCKAR DAPK1 HP TP53

Drugs & Therapeutics for Cholecystitis

Drugs for Cholecystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 178)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nefopam Approved, Investigational Phase 4 13669-70-0
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
4
Metronidazole Approved Phase 4 443-48-1 4173
5
Remifentanil Approved Phase 4 132875-61-7 60815
6
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
7
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
8
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
9
Tigecycline Approved Phase 4 220620-09-7 5282044
10
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
12 Hydrotalcite Approved, Experimental, Investigational Phase 4 12304-65-3
13
Aluminum hydroxide Approved, Investigational Phase 4 21645-51-2
14
Sucralfate Approved Phase 4 54182-58-0
15
Magnesium hydroxide Approved, Investigational Phase 4 1309-42-8
16
Fosaprepitant Approved Phase 4 172673-20-0 219090
17
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-61-2, 135729-56-5 148211
18
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
19
tannic acid Approved Phase 4 1401-55-4
20
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
21
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
22
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
23
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
24
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
25 Hemostatics Phase 4
26 Coagulants Phase 4
27 Antibiotics, Antitubercular Phase 4
28 Anti-Infective Agents Phase 4
29 Anti-Bacterial Agents Phase 4
30 Micronutrients Phase 4
31 Trace Elements Phase 4
32 Antioxidants Phase 4
33 Vitamins Phase 4
34 Protective Agents Phase 4
35 Nutrients Phase 4
36 Adjuvants, Immunologic Phase 4
37 Immunologic Factors Phase 4
38 Anesthetics, General Phase 4
39 Anesthetics, Intravenous Phase 4
40 Cyclooxygenase Inhibitors Phase 4
41 Cyclooxygenase 2 Inhibitors Phase 4
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4
43 Antirheumatic Agents Phase 4
44 Analgesics, Opioid Phase 4
45 Sodium Channel Blockers Phase 4
46 Diuretics, Potassium Sparing Phase 4
47 Anti-Arrhythmia Agents Phase 4
48 Hypnotics and Sedatives Phase 4
49 Antiparasitic Agents Phase 4
50 Antiprotozoal Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 168)
# Name Status NCT ID Phase Drugs
1 THE USE OF FLOSEAL GELATIN MATRIX FOR THE HAEMOSTASIS DURING LAPAROSCOPIC CHOLECYSTECTOMY FOR ACUTE CHOLECYSTITIS; EFFICACY AND SAFETY EVALUATED IN A MULTICENTER, PROSPECTIVE, OPEN LABEL TRIAL WITH AN HISTORICAL CONTROL GROUP. (G.L.A. STUDY: GELATIN Matrix in Laparoscopic Cholecystectomy for Acute Cholecystitis) Unknown status NCT01126281 Phase 4
2 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
3 DOLCE Study: Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized, Controlled Trial Unknown status NCT01052727 Phase 4
4 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy Due to Acute Cholecystitis. Is it Necessary? Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
5 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
6 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
7 Opioid-free Total Intravenous Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy; Comparison With Propofol, Remifentanil Infusions Completed NCT01833819 Phase 4 Dexmedetomidine and lidocaine;Remifentanil
8 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
9 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Randomized Multi-center Study Completed NCT01744847 Phase 4
10 Studie Naar De Effectiviteit Van Ursodeoxycholzuur Ter Preventie Van Galsteen-Gerelateerde Klachten Bij patiënten in Afwachting Van Een Cholecystectomie Completed NCT00161083 Phase 4 ursodeoxycholic acid
11 The Role of a Single Oral Dose (2g) of Vitamin C in Reducing Intensity of Pain and Opioids Consumption in Patients Undergoing Laparoscopic Cholecystectomy. A Randomized, Double-blinded, Placebo-controlled Study Completed NCT01322061 Phase 4 Ascorbic Acid
12 A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment: Randomized Trial Completed NCT03635372 Phase 4 Alginate;Sucralfate;Hydrotalcite
13 Covered Versus Uncovered Metal Stents for Management of Distal Malignant Biliary Obstruction? Results of a Randomized Prospective Study. Completed NCT00280709 Phase 4
14 Multi-Port vs. Single-port Cholecystectomy Completed NCT01104727 Phase 4
15 COMPARATIVE STUDY BETWEEN PALONOSETRON AND FOSAPREPITANT IN THE PROFILAXIA OF POSTOPERATIVE NAUSEA AND VOMITING IN WOMEN SUBMITTED TO VIDEOLAPAROSCOPIC COLECISTECTOMIES Recruiting NCT03586817 Phase 4 Palonosetron;Fosaprepitant
16 Effect of Deep Versus Moderate Neuromuscular Blockade on Peak Airway Pressures During Elective Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
17 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
18 Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
19 Drainage is Not Necessary Procedure After Laparoscopic Cholecystectomy Due to Severe Acute Cholecystitis Unknown status NCT01625247 Phase 3
20 Single Port Access Cholecystectomy Versus Standard Laparoscopic Cholecystectomy - Randomized Study Unknown status NCT00904865 Phase 2, Phase 3
21 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy = ACDC-study Completed NCT00447304 Phase 3 moxifloxacin
22 Endosonography-guided Gallbladder Drainage (EGBD) Versus Percutaneous Cholecystostomy (PC) in Patients Suffering From Acute Cholecystitis That Are Unsuitable for Surgery. A Randomized Controlled Trial. Completed NCT02212717 Phase 2, Phase 3
23 Piperacllin Versus Placebo in Patients Undergoing Surgery for Acute Cholecystitis Completed NCT02619149 Phase 3 Piperacillin-tazobactam combination product;Saline solution
24 Antibiotic Treatment Versus no Antibiotics in the Postoperative Acute Cholecystitis Low and Moderately Severe Completed NCT01015417 Phase 3 Amoxicillin clavulanic acid
25 A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
26 A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
27 An Expertise-based Randomized Controlled Trial Comparing Minilaparotomy Cholecystectomy and Laparoscopic Cholecystectomy Completed NCT00370344 Phase 2, Phase 3
28 Dexamethasone Improves Postoperative Symptoms in Patients Undergoing Elective Laparoscopic Cholecystectomy: A Randomised Clinical Trial. Completed NCT01030614 Phase 3 Dexamethasone;placebo
29 Prospective Randomized Clinical Trial Comparing Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery on Cholecystectomy Completed NCT01558414 Phase 3
30 Residual Gastric Volume Measured by Upper Digestive Endoscopy 2h After the Ingestion of a Beverage Containing Carbohydrates Plus Whey Protein. A Controlled, Randomized Clinical Trial Completed NCT01828645 Phase 2, Phase 3
31 Prospective Study for the Effects of Biphenyl Dimethyl Dicarboxylate and Ursodeoxycolic Acid Therapy on Liver Function and Quality of Life After Laparoscopic Cholecystectomy Recruiting NCT03578055 Phase 3 BDD with UDCA;Placebo
32 Clinical Outcomes Trial of Laparoscopic Assisted Transgastric Endoscopic Cholecystectomy Unknown status NCT01174069 Phase 1, Phase 2
33 Does it Make Sense to Give Postoperative Antibiotics to Patients With an Uncomplicated Acute Cholecystitis Completed NCT00323648 Phase 2 Whether or not giving postoperatively antibiotics to patients with an uncomplicated acute cholecystitis
34 Antibiotic Prophylaxis for ERCP: a Comparison of Intravenous Ceftriaxone With Intravenous Moxifloxacin in the Prophylaxis of Cholangitis Completed NCT02098486 Phase 2 Moxifloxacin;ceftriaxone
35 Efficacy and Safety of Dengue Vaccine in Healthy Children Aged 4 to 11 Years in Thailand Completed NCT00842530 Phase 2
36 MANAGEMENT OF THE PATIENT WITH ACUTE ABDOMEN SUBMITTED TO URGENT ABDOMINAL SURGERY: a Pilot Randomized Multicentre Study Completed NCT01911702 Phase 2
37 Pilot Study to Assess Safety and Efficacy Of An Endoscopic Bipolar Radiofrequency Probe (EndoHPB) In the Management of Unresectable Bile Duct and Pancreatic Cancer Unknown status NCT02042859 Phase 1
38 Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy Sub-Study Completed NCT02070627 Phase 1 Indocyanine Green (ICG)
39 Pilot Study to Assess the Safety and Pharmacokinetics of 70-150μm Drug Eluting Beads Loaded With Irinotecan (DEBIRI) in the Treatment of Hepatic Colorectal Metastases Completed NCT02350400 Phase 1
40 Phase I Clinical Trial on Intra-tumoral Ipilimumab Plus Intravenous Nivolumab Following the Resection of Recurrent Glioblastoma Recruiting NCT03233152 Phase 1 Ipilimumab (YervoyTM, 50 mg/10 mL solution);Nivolumab (OpdivoTM, 40 mg/4mL solution)
41 Laparoscopic Cholecystectomy Using Transvaginal Endoscopic Assistance Withdrawn NCT00815438 Phase 1
42 Percutaneous Drainage in a Setting of Acute Cholecystitis Severity Grade III and Correlation With Clinical Outcomes Unknown status NCT03087747
43 Acute Cholecystitis: Early Versus Delayed Laparoscopic Cholecystectomy; Randomized Prospective Study Unknown status NCT02130245
44 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
45 Prediction of Postoperative Pain by Injection Pain of Propofol Unknown status NCT03021447
46 Effect of Vitamin C on Postoperative Pain After Laparoscopic Cholecystectomy; a A Prospective Randomized Controlled Trial Unknown status NCT02553551 Vitamin C;Placebo
47 A Comparison of Robot-assisted Single Site and Laparoscopic Single-incision Cholecystectomy for Benign Gallbladder Unknown status NCT02485392
48 Multicenter Cohort Study: To Explore the Standard Surgical Indication in Gallbladder Benign Disease Unknown status NCT02951169
49 Proficiency-based Versus Free Laparoscopic Training in Cholecystectomy Using the Simbionix LAP Mentor™. A Randomized Controlled Trial Unknown status NCT01615549
50 Initial Cholecystectomy With Intraoperative Cholangiography for Patients at Intermediate Risk of Common Bile Duct Stone Migration : Prospective Validation and Analysis Unknown status NCT02461147

Search NIH Clinical Center for Cholecystitis

Cochrane evidence based reviews: cholecystitis

Genetic Tests for Cholecystitis

Genetic tests related to Cholecystitis:

# Genetic test Affiliating Genes
1 Cholecystitis 29 ABCB4

Anatomical Context for Cholecystitis

MalaCards organs/tissues related to Cholecystitis:

41
Liver, Testes, Pancreas, Heart, Colon, Lung, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Cholecystitis:

19
Gallbladder

Publications for Cholecystitis

Articles related to Cholecystitis:

(show top 50) (show all 13638)
# Title Authors PMID Year
1
Gallbladder carcinoma manifesting as acute cholecystitis: clinical and computed tomographic features. 9 38
19744453 2009
2
Acute transient hepatocellular injury in cholelithiasis and cholecystitis without evidence of choledocholithiasis. 9 38
19673021 2009
3
Usefulness of fatty meal-stimulated cholescintigraphy in the diagnosis and treatment of chronic acalculous cholecystitis. 9 38
19225936 2009
4
Liver enzyme elevation and normal pulmonary function in an adult with a declining forced expiratory volume in 1 second. 9 38
18534093 2008
5
Expression and functional pharmacology of the bradykinin B1 receptor in the normal and inflamed human gallbladder. 9 38
18182589 2008
6
Effect of sequential administration of an opioid and cholecystokinin on gallbladder ejection fraction: brief communication. 9 38
16954554 2006
7
Stimulation with fatty meal (Lipomul) to assess gallbladder emptying in children with chronic acalculous cholecystitis. 9 38
12883305 2003
8
Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro. 9 38
12851878 2003
9
Influence of cholecystitis state on pharmacological response to cholecystokinin of isolated human gallbladder with gallstones. 9 38
12772786 2003
10
Gallbladder ejection fraction: an accurate evaluation of symptomatic acalculous gallbladder disease. 9 38
12872903 2003
11
Mechanisms of impaired gallbladder contractile response in chronic acalculous cholecystitis. 9 38
12022997 2002
12
Cholecystokinin cholescintigraphy: victim of its own success? 9 38
10616884 1999
13
Chronic acalculous cholecystitis: reproduction of pain with cholecystokinin and relief of symptoms with cholecystectomy. 9 38
10388344 1999
14
The clinical utility of quantitative cholescintigraphy: the significance of gallbladder dysfunction. 9 38
9596151 1998
15
Acute cholecystitis in AIDS patients: correlation of Tc-99m hepatobiliary scintigraphy with histopathologic laboratory findings and CD4 counts. 9 38
9554194 1998
16
Pharmacologic intervention for the diagnosis of acute cholecystitis: cholecystokinin pretreatment or morphine, or both? 9 38
9098218 1997
17
Cholecystokinin and morphine pharmacological intervention during 99mTc-HIDA cholescintigraphy: a rational approach. 9 38
8623048 1996
18
Abnormal gallbladder nuclear ejection fraction predicts success of cholecystectomy in patients with biliary dyskinesia. 9 38
8273847 1993
19
Cholecystokinin cholescintigraphy: detection of abnormal gallbladder motor function in patients with chronic acalculous gallbladder disease. 9 38
1880571 1991
20
[The blood level of cobalamin as an indicator of the functional status of the liver in jaundice of different etiologies]. 9 38
1721943 1991
21
Chronic right upper quadrant pain without gallstones: does HIDA scan predict outcome after cholecystectomy? 9 38
2375327 1990
22
[Sonographic criteria of acute acalculous cholecystitis.Critical observation of the clinical records of sedated, ventilated and parenterally nourished patients]. 9 38
2121670 1990
23
Cholecystokinin sonography: lack of utility in diagnosis of acute acalculous cholecystitis. 9 38
2183285 1990
24
Outcomes of laparoscopic cholecystectomy for xanthogranulomatous cholecystitis. 38
31341622 2019
25
Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial. 38
31326345 2019
26
MPZL1 is highly expressed in advanced gallbladder carcinoma and promotes the aggressive behavior of human gallbladder carcinoma GBC‑SD cells. 38
31322261 2019
27
Biotoxicity of diclofenac on two larval amphibians: Assessment of development, growth, cardiac function and rhythm, behavior and antioxidant system. 38
31150883 2019
28
IL-33 overexpression in gallbladder cancers associated with pancreatobiliary maljunction. 38
30882917 2019
29
EUS-Guided Biliary Drainage for Unresectable Malignant Biliary Obstruction: 10-Year Experience of 99 Cases at a Single Center. 38
29656352 2019
30
Case report: Acute hepatic failure secondary to metastatic LIVER'S infiltration by upper tract urothelial carcinoma. 38
31388417 2019
31
Acute acalculous cholecystitis due to Fusarium species and review of the literature on fungal cholecystitis. 38
31166627 2019
32
Endoscopic Methods for Gallbladder Drainage. 38
31317444 2019
33
Use of minimally invasive surgery in emergency general surgery procedures. 38
31388806 2019
34
The impact of dementia on surgical outcomes of laparoscopic cholecystectomy for symptomatic cholelithiasis and acute cholecystitis: A retrospective study. 38
31389183 2019
35
Abdominal Pain in the Elderly: An Unusual Case of Chronic Mesenteric Ischemia in the Emergency Department. 38
31403102 2019
36
[French comment on article Endoscopic ultrasound-guided gallbladder drainage versus percutaneous cholecystostomy for high risk surgical patients with acute cholecystitis: a systematic review and meta-analysis]. 38
31344739 2019
37
An Acute General Surgical Unit (AGSU) Negates the Impact of the Tokyo Guidelines 2018 (TG18) Diagnostic Criteria for the Treatment of Acute Cholecystitis. 38
31384994 2019
38
Endoscopic ultrasound-guided gallbladder drainage versus percutaneous cholecystostomy for high risk surgical patients with acute cholecystitis: a systematic review and meta-analysis. 38
31238375 2019
39
Extended Postoperative Antibiotics Versus No Postoperative Antibiotics in Patients Undergoing Emergency Cholecystectomy for Acute Calculous Cholecystitis: A Systematic Review and Meta-Analysis. 38
30873901 2019
40
Impact of transient hepatic attenuation differences on computed tomography scans in the diagnosis of acute gangrenous cholecystitis. 38
31125498 2019
41
First in-Human Gallbladder Cryoablation in a Patient with Acute Calculous Cholecystitis Initially Treated with a Cholecystostomy Tube. 38
31003847 2019
42
Classification of the cystic duct patterns and endoscopic transpapillary cannulation of the gallbladder to prevent post-ERCP cholecystitis. 38
31382888 2019
43
The impact of antithrombotic therapy in patients undergoing emergency laparoscopic cholecystectomy for acute cholecystitis - A single center experience. 38
31430063 2019
44
Biliary Disease in Immunocompromised Patients: a Single-Center Retrospective Analysis. 38
30635828 2019
45
Acute acalculous cholecystitis as a manifestation of ehrlichiosis. 38
31155368 2019
46
White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED. 38
31119578 2019
47
Incidence and Consequence of Nontarget Embolization Following Bland Hepatic Arterial Embolization. 38
31073823 2019
48
Emphysematous Cholecystitis. 38
31433924 2019
49
DRESS masquerading as acute cholecystitis. 38
31421066 2019
50
An alternative percutaneous technique for gallbladder drainage using lumen-apposing metal stents. 38
31392512 2019

Variations for Cholecystitis

ClinVar genetic disease variations for Cholecystitis:

6 (show all 12)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 ABCB4 NM_018849.3(ABCB4): c.1328_1329delinsCAA (p.Gln443fs) indel Pathogenic rs387906528 7:87072662-87072663 7:87443346-87443347
2 ABCB4 NM_018849.3(ABCB4): c.1633C> G (p.Arg545Gly) single nucleotide variant Pathogenic rs397514620 7:87069081-87069081 7:87439765-87439765
3 ABCB4 NM_018849.3(ABCB4): c.3136C> T (p.Arg1046Ter) single nucleotide variant Pathogenic 7:87037496-87037496 7:87408180-87408180
4 ABCB4 NM_018849.3(ABCB4): c.2932T> C (p.Ser978Pro) single nucleotide variant Likely pathogenic 7:87038701-87038701 7:87409385-87409385
5 ABCB4 NM_018849.3(ABCB4): c.2869C> T (p.Arg957Ter) single nucleotide variant Likely pathogenic rs121918440 7:87041264-87041264 7:87411948-87411948
6 ABCB4 NM_018849.3(ABCB4): c.959C> T (p.Ser320Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs72552778 7:87076396-87076396 7:87447080-87447080
7 ABCB4 NM_018849.3(ABCB4): c.1769G> A (p.Arg590Gln) single nucleotide variant Conflicting interpretations of pathogenicity rs45575636 7:87060844-87060844 7:87431528-87431528
8 ABCB4 NM_018849.3(ABCB4): c.101C> T (p.Thr34Met) single nucleotide variant Uncertain significance rs142794414 7:87101971-87101971 7:87472655-87472655
9 ABCB4 NM_018849.3(ABCB4): c.140G> A (p.Arg47Gln) single nucleotide variant Uncertain significance rs372685632 7:87092220-87092220 7:87462904-87462904
10 ABCB4 NM_018849.3(ABCB4): c.217C> G (p.Leu73Val) single nucleotide variant Uncertain significance rs8187788 7:87092143-87092143 7:87462827-87462827
11 ABCB4 NM_018849.3(ABCB4): c.3502C> T (p.Pro1168Ser) single nucleotide variant Uncertain significance rs121918442 7:87035609-87035609 7:87406293-87406293
12 ABCB4 NM_018849.3(ABCB4): c.523A> G (p.Thr175Ala) single nucleotide variant Benign/Likely benign rs58238559 7:87082273-87082273 7:87452957-87452957

Expression for Cholecystitis

Search GEO for disease gene expression data for Cholecystitis.

Pathways for Cholecystitis

Pathways related to Cholecystitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.28 TP53 RASSF1 DAPK1 CDKN2A CDH1
2 10.88 TP53 RASSF1 DAPK1 CDKN2A CDH1
3
Show member pathways
10.66 TP53 CDKN2A
4 10.6 TP53 CDKN2A
5 9.8 MUC6 CCK

GO Terms for Cholecystitis

Cellular components related to Cholecystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.33 HP F2 ALB
2 extracellular exosome GO:0070062 9.23 MUC1 KRT18 HP GPT F2 CDH1
3 Golgi lumen GO:0005796 9.13 MUC6 MUC1 F2

Biological processes related to Cholecystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.5 TP53 RASSF1 CDKN2A
2 positive regulation of protein oligomerization GO:0032461 9.26 TP53 CCK
3 replicative senescence GO:0090399 9.16 TP53 CDKN2A
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 TP53 MUC1
5 Ras protein signal transduction GO:0007265 8.8 TP53 RASSF1 CDKN2A

Sources for Cholecystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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