MCID: CHL013
MIFTS: 37

Cholecystolithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholecystolithiasis

MalaCards integrated aliases for Cholecystolithiasis:

Name: Cholecystolithiasis 12 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11151
MeSH 45 D041761
NCIt 51 C34443
SNOMED-CT 69 44900007
UMLS 74 C0947622

Summaries for Cholecystolithiasis

MalaCards based summary : Cholecystolithiasis is related to choledocholithiasis and cholecystitis. An important gene associated with Cholecystolithiasis is UVRAG (UV Radiation Resistance Associated), and among its related pathways/superpathways are TGF-beta signaling pathway (KEGG) and Endochondral Ossification. The drugs tannic acid and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include skin, pancreas and liver.

Wikipedia : 77 A gallstone is a stone formed within the gallbladder out of bile components. The term cholelithiasis may... more...

Related Diseases for Cholecystolithiasis

Graphical network of the top 20 diseases related to Cholecystolithiasis:



Diseases related to Cholecystolithiasis

Symptoms & Phenotypes for Cholecystolithiasis

Drugs & Therapeutics for Cholecystolithiasis

Drugs for Cholecystolithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 262)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4,Not Applicable 1401-55-4
2
Remifentanil Approved Phase 4 132875-61-7 60815
3
Benzocaine Approved, Investigational Phase 4,Not Applicable 94-09-7, 1994-09-7 2337
4
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
5
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
6
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
7
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
8
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
9
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
10
Esketamine Approved, Investigational Phase 4 33643-46-8
11
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
12
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
13
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
14
Clonidine Approved Phase 4 4205-90-7 2803
15
Acetaminophen Approved Phase 4 103-90-2 1983
16
Nefopam Approved, Investigational Phase 4 13669-70-0
17
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
18
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 128-13-2 31401
19
Ondansetron Approved Phase 4 99614-02-5 4595
20
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
21
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
22
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
23
Pseudoephedrine Approved Phase 4 90-82-4 7028
24
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
25
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
26
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
27
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
28
Ephedrine Approved Phase 4 299-42-3 9294
29
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
30
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
31
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
32
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
33
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
34
Etomidate Approved Phase 4 33125-97-2 36339 667484
35
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
36
Fosaprepitant Approved Phase 4 172673-20-0 219090
37
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
38
Palonosetron Approved, Investigational Phase 4 135729-61-2, 119904-90-4, 135729-56-5 148211
39
Sulbactam Approved Phase 4 68373-14-8
40
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
41
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
42
Sultamicillin Approved, Investigational Phase 4 76497-13-7
43
Tauroursodeoxycholic acid Experimental, Investigational Phase 4 14605-22-2 12443252
44
Taurochenodeoxycholic acid Experimental Phase 4 516-35-8 387316
45
Substance P Investigational Phase 4 33507-63-0 44359816
46 Cholagogues and Choleretics Phase 4,Phase 3,Phase 2,Not Applicable
47 Antiviral Agents Phase 4
48 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
49 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 310)
# Name Status NCT ID Phase Drugs
1 The Discovery of the Double Sphincter in Gallbladder Unknown status NCT01998451 Phase 4 Tauroursodeoxycholic acid
2 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
3 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
4 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
5 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
6 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
7 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
8 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
9 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
10 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
11 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
12 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
13 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
14 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
15 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
16 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
17 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
18 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
19 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
20 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
21 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
22 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
23 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
24 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
25 Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy Completed NCT01717222 Phase 4 Intraperitoneal Lignocaine;Intravenous Lignocaine
26 Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain Completed NCT03265223 Phase 4 0.2% ropivacaine
27 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
28 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
29 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
30 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
31 PALONOSETRON X FOSAPREPITANT IN PONV Recruiting NCT03586817 Phase 4 Palonosetron;Fosaprepitant
32 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Active, not recruiting NCT03168555 Phase 4 chenodeoxycholic acid
33 COMPARISON OF INTRAOPERATIVE LOCAL ANESTHETIC APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN LAPAROSCOPIC CHOLECYSTECTOMY PATIENTS Active, not recruiting NCT03790007 Phase 4 Bupivacaine
34 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
35 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
36 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
37 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
38 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy Unknown status NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
39 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
40 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
41 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
42 Renalof in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
43 Clinical Trials for the Prevention of Gallstone Formation After Gastrectomy in Patient With Gastric Cancer Completed NCT02490111 Phase 3 DWJ1319;Placebo
44 Compare Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones Completed NCT00164853 Phase 3
45 Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery Completed NCT00835250 Phase 3
46 Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Completed NCT00370344 Phase 2, Phase 3
47 Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery for Cholecystectomy Completed NCT01558414 Phase 3
48 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
49 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy Completed NCT00447304 Phase 3 moxifloxacin
50 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo

Search NIH Clinical Center for Cholecystolithiasis

Cochrane evidence based reviews: cholecystolithiasis

Genetic Tests for Cholecystolithiasis

Anatomical Context for Cholecystolithiasis

MalaCards organs/tissues related to Cholecystolithiasis:

42
Skin, Pancreas, Liver, Kidney, Bone, Colon

Publications for Cholecystolithiasis

Articles related to Cholecystolithiasis:

(show top 50) (show all 94)
# Title Authors Year
1
Combination of serum gamma-glutamyltransferase and alkaline phosphatase in predicting the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis. ( 30705891 )
2019
2
Cavernous Transformation of the Portal Vein Secondary to Cholecystolithiasis. ( 29786056 )
2018
3
Needleless Transcutaneous Neuromodulation Accelerates Postoperative Recovery Mediated via Autonomic and Immuno-Cytokine Mechanisms in Patients With Cholecystolithiasis. ( 30277014 )
2018
4
Minilaparoscopic versus single incision cholecystectomy for the treatment of cholecystolithiasis: a meta-analysis and systematic review. ( 28830403 )
2017
5
Minimally Invasive Cholecystolithotomy to Treat Cholecystolithiasis in Children: A Single-center Experience With 23 Cases. ( 28614174 )
2017
6
A Review of 7 Cases of Laparoscopic Cholecystectomy for Pediatric Cholecystolithiasis. ( 28904273 )
2017
7
Preoperative hypoalbuminemia is an independent risk factor for conversion from laparoscopic to open cholecystectomy in patients with cholecystolithiasis. ( 27283337 )
2016
8
Single-stage management with combined tri-endoscopic approach for concomitant cholecystolithiasis and choledocholithiasis. ( 27126621 )
2016
9
Intraoperative endoscopic nasobiliary drainage over primary closure of the common bile duct for choledocholithiasis combined with cholecystolithiasis: a cohort study of 211 cases. ( 27864721 )
2016
10
Endoscopic-Laparoscopic Cholecystolithotomy in Treatment of Cholecystolithiasis Compared With Traditional Laparoscopic Cholecystectomy. ( 27579981 )
2016
11
Endoscopic minimal invasive cholecystolithotomy vs laparoscopic cholecystectomy in treatment of cholecystolithiasis in China: a meta-analysis. ( 25527194 )
2015
12
Prospective multicentre cohort study of patient-reported outcomes after cholecystectomy for uncomplicated symptomatic cholecystolithiasis. ( 26201942 )
2015
13
Abdominal regional fat distribution on MRI correlates with cholecystolithiasis. ( 25310024 )
2014
14
Single-incision laparoscopic cholecystectomy for cholecystolithiasis coinciding with cavernous transformation of the portal vein: report of a case. ( 23578019 )
2013
15
Meta-analysis of laparoscopic versus open cholecystectomy for patients with liver cirrhosis and symptomatic cholecystolithiasis. ( 23034741 )
2013
16
The predictive value of pre-operative symptoms including upper gastrointestinal endoscopy before laparoscopic cholecystectomy for elective symptomatic cholecystolithiasis. ( 24899324 )
2013
17
A new strategy of minimally invasive surgery for cholecystolithiasis: calculi removal and gallbladder preservation. ( 24481280 )
2013
18
Symptomatic cholecystolithiasis after cholecystectomy. ( 23362056 )
2013
19
Dubin-Johnson syndrome with cholecystolithiasis and choledocholithiasis. ( 23708305 )
2013
20
Cholecystolithiasis after gastric bypass: a clinical, biochemical, and ultrasonographic 3-year follow-up study. ( 22767176 )
2012
21
Tiny cystine stones in the gallbladder of a patient with cholecystolithiasis complicating acute cholecystitis: a case report. ( 22472465 )
2012
22
Heterotopic pancreas in gall bladder associated with chronic cholecystolithiasis. ( 23776830 )
2012
23
Development of a real-time PCR assay for the detection of Clonorchis sinensis DNA in gallbladder bile and stone samples from patients with cholecystolithiasis. ( 22669695 )
2012
24
Cholecystolithiasis is associated with Clonorchis sinensis infection. ( 22905137 )
2012
25
Long-term outcome of endoscopic papillotomy for choledocholithiasis with cholecystolithiasis. ( 20447201 )
2010
26
Open, small-incision, or laparoscopic cholecystectomy for patients with symptomatic cholecystolithiasis. An overview of Cochrane Hepato-Biliary Group reviews. ( 20091665 )
2010
27
Systematic review: open, small-incision or laparoscopic cholecystectomy for symptomatic cholecystolithiasis. ( 19035965 )
2009
28
Randomized clinical trial of small-incision and laparoscopic cholecystectomy in patients with symptomatic cholecystolithiasis: primary and clinical outcomes. ( 18427025 )
2008
29
Prevalence of cholecystolithiasis and its management among kidney/pancreas-transplanted type 1 (insulin-dependent) diabetic patients. ( 18499558 )
2008
30
Effect of Lidan Granule on bile lithogenesis in patients with choledocholithiasis combined with cholecystolithiasis. ( 18679607 )
2008
31
Gastric emptying before and after cholecystectomy in patients with cholecystolithiasis. ( 18705281 )
2008
32
Randomized Clinical Trial of Small-Incision and Laparoscopic Cholecystectomy in Patients With Symptomatic Cholecystolithiasis: Primary and Clinical Outcomes-Invited Critique. ( 28715572 )
2008
33
Anaesthesiological considerations in small-incision and laparoscopic cholecystectomy in symptomatic cholecystolithiasis: implications for pulmonary function. A randomized clinical trial. ( 17697302 )
2007
34
Behavior of the common bile duct diameter before and 12 years after choledochostomy for cholecystolithiasis and choledocholithiasis. A prospective study. ( 17682828 )
2007
35
Laparoscopic versus small-incision cholecystectomy for patients with symptomatic cholecystolithiasis. ( 17054284 )
2006
36
Laparoscopic versus open cholecystectomy for patients with symptomatic cholecystolithiasis. ( 17054285 )
2006
37
Small-incision versus open cholecystectomy for patients with symptomatic cholecystolithiasis. ( 17054215 )
2006
38
Relation of gallbladder function and Helicobacter pylori infection to gastric mucosa inflammation in patients with symptomatic cholecystolithiasis. ( 16641551 )
2006
39
Gallstone disease: Surgical aspects of symptomatic cholecystolithiasis and acute cholecystitis. ( 17127186 )
2006
40
Acute biliary pancreatitis and cholecystolithiasis in a child: one time treatment with laparoendoscopic "rendez-vous" procedure. ( 16586553 )
2006
41
Current status of laparoscopic therapy of cholecystolithiasis and common bile duct stones. ( 16352891 )
2005
42
Bouveret's syndrome: a rare complication of cholecystolithiasis. ( 16174186 )
2005
43
Transforming growth factor-beta pathway is activated in cholecystolithiasis. ( 15702358 )
2005
44
Somatosensory changes in the referred pain area in patients with cholecystolithiasis. ( 16003137 )
2005
45
Detection of nanobacteria in serum, bile and gallbladder mucosa of patients with cholecystolithiasis. ( 15780215 )
2005
46
Short- versus long-sequence MRI cholangiography for the preoperative imaging of the common bile duct in patients with cholecystolithiasis. ( 16021379 )
2005
47
Segmental adenomyomatosis of the gallbladder predisposes to cholecystolithiasis. ( 15549435 )
2004
48
Medical image. Magnetic resonance cholangiopancreatography (MRCP) demonstrating cholecystolithiasis and aberrant pancreatic duct anatomy. ( 15326512 )
2004
49
Symptomatic cholecystolithiasis after laparoscopic cholecystectomy. ( 15106630 )
2004
50
Predictions and associations of cholecystectomy in patients with cholecystolithiasis treated with extracorporeal shock wave lithotripsy. ( 15628729 )
2004

Variations for Cholecystolithiasis

Expression for Cholecystolithiasis

Search GEO for disease gene expression data for Cholecystolithiasis.

Pathways for Cholecystolithiasis

Pathways related to Cholecystolithiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.91 BMP6 TGFB1
2 10.44 BMP6 TGFB1

GO Terms for Cholecystolithiasis

Biological processes related to Cholecystolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to mechanical stimulus GO:0071260 9.48 BMP6 TGFB1
2 positive regulation of epithelial cell proliferation GO:0050679 9.46 BMP6 TGFB1
3 cell development GO:0048468 9.43 BMP6 TGFB1
4 regulation of MAPK cascade GO:0043408 9.4 BMP6 TGFB1
5 SMAD protein signal transduction GO:0060395 9.37 BMP6 TGFB1
6 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.32 BMP6 TGFB1
7 positive regulation of protein secretion GO:0050714 9.26 BMP6 TGFB1
8 positive regulation of bone mineralization GO:0030501 9.16 BMP6 TGFB1
9 positive regulation of SMAD protein signal transduction GO:0060391 8.96 BMP6 TGFB1
10 receptor catabolic process GO:0032801 8.62 TGFB1 UVRAG

Molecular functions related to Cholecystolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 8.62 BMP6 TGFB1

Sources for Cholecystolithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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