MCID: CHL013
MIFTS: 34

Cholecystolithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholecystolithiasis

MalaCards integrated aliases for Cholecystolithiasis:

Name: Cholecystolithiasis 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11151
MeSH 44 D041761
NCIt 50 C34443
SNOMED-CT 68 44900007
UMLS 73 C0947622

Summaries for Cholecystolithiasis

MalaCards based summary : Cholecystolithiasis is related to choledocholithiasis and cholecystitis. An important gene associated with Cholecystolithiasis is UVRAG (UV Radiation Resistance Associated), and among its related pathways/superpathways are TGF-beta signaling pathway (KEGG) and Endochondral Ossification. The drugs Propofol and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include pancreas, skin and liver.

Wikipedia : 76 A gallstone is a stone formed within the gallbladder out of bile components. The term cholelithiasis may... more...

Related Diseases for Cholecystolithiasis

Graphical network of the top 20 diseases related to Cholecystolithiasis:



Diseases related to Cholecystolithiasis

Symptoms & Phenotypes for Cholecystolithiasis

Drugs & Therapeutics for Cholecystolithiasis

Drugs for Cholecystolithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 247)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
2 tannic acid Approved Phase 4
3
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
8
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
9
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
10
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
11
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
12
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273
13
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
14 Nefopam Approved, Investigational Phase 4 13669-70-0
15
Clonidine Approved Phase 4 4205-90-7 2803
16
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
17
Acetaminophen Approved Phase 4 103-90-2 1983
18
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 128-13-2 31401
19
Ondansetron Approved Phase 4 99614-02-5 4595
20
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
21
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
22
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
23
Pseudoephedrine Approved Phase 4 90-82-4 7028
24
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
25
Morphine Approved, Investigational Phase 4 57-27-2 5288826
26
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
27
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
28
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
29
Ephedrine Approved Phase 4 299-42-3 9294
30
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
31
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
32
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
33
Etomidate Approved Phase 4 33125-97-2 667484 36339
34
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
35
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
36
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-61-2, 135729-56-5 148211
37
Fosaprepitant Approved Phase 4 172673-20-0 219090
38
Sultamicillin Approved, Investigational Phase 4 76497-13-7
39
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
40
Sulbactam Approved Phase 4 68373-14-8
41
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
42
Tauroursodeoxycholic acid Experimental, Investigational Phase 4 14605-22-2 12443252
43
Substance P Investigational Phase 4 33507-63-0 44359816
44 Taurochenodeoxycholic Acid Phase 4
45 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
47 Cholagogues and Choleretics Phase 4,Phase 3,Phase 2,Not Applicable
48 Antiviral Agents Phase 4
49 Central Nervous System Depressants Phase 4,Phase 1,Not Applicable
50 Analgesics, Opioid Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 301)
# Name Status NCT ID Phase Drugs
1 The Discovery of the Double Sphincter in Gallbladder Unknown status NCT01998451 Phase 4 Tauroursodeoxycholic acid
2 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
3 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
4 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
5 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
6 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
7 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
8 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
9 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
10 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
11 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
12 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
13 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
14 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
15 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
16 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
17 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
18 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
19 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
20 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
21 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
22 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
23 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
24 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
25 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
26 Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy Completed NCT01717222 Phase 4 Intraperitoneal Lignocaine;Intravenous Lignocaine
27 Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain Completed NCT03265223 Phase 4 0.2% ropivacaine
28 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
29 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
30 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
31 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Active, not recruiting NCT03168555 Phase 4 chenodeoxycholic acid
32 COMPARISON OF INTRAOPERATIVE LOCAL ANESTHETIC APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN LAPAROSCOPIC CHOLECYSTECTOMY PATIENTS Active, not recruiting NCT03790007 Phase 4 Bupivacaine
33 PALONOSETRON X FOSAPREPITANT IN PONV Not yet recruiting NCT03586817 Phase 4 Palonosetron;Fosaprepitant
34 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
35 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
36 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
37 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
38 Clinical Trials for the Prevention of Gallstone Formation After Gastrectomy in Patient With Gastric Cancer Unknown status NCT02490111 Phase 3 DWJ1319;Placebo
39 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
40 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
41 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
42 Renalof in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
43 Compare Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones Completed NCT00164853 Phase 3
44 Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery Completed NCT00835250 Phase 3
45 Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Completed NCT00370344 Phase 2, Phase 3
46 Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery for Cholecystectomy Completed NCT01558414 Phase 3
47 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
48 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy Completed NCT00447304 Phase 3 moxifloxacin
49 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
50 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3

Search NIH Clinical Center for Cholecystolithiasis

Cochrane evidence based reviews: cholecystolithiasis

Genetic Tests for Cholecystolithiasis

Anatomical Context for Cholecystolithiasis

MalaCards organs/tissues related to Cholecystolithiasis:

41
Pancreas, Skin, Liver, Kidney, Colon

Publications for Cholecystolithiasis

Articles related to Cholecystolithiasis:

(show top 50) (show all 93)
# Title Authors Year
1
Cavernous Transformation of the Portal Vein Secondary to Cholecystolithiasis. ( 29786056 )
2018
2
Needleless Transcutaneous Neuromodulation Accelerates Postoperative Recovery Mediated via Autonomic and Immuno-Cytokine Mechanisms in Patients With Cholecystolithiasis. ( 30277014 )
2018
3
Minilaparoscopic versus single incision cholecystectomy for the treatment of cholecystolithiasis: a meta-analysis and systematic review. ( 28830403 )
2017
4
Minimally Invasive Cholecystolithotomy to Treat Cholecystolithiasis in Children: A Single-center Experience With 23 Cases. ( 28614174 )
2017
5
A Review of 7 Cases of Laparoscopic Cholecystectomy for Pediatric Cholecystolithiasis. ( 28904273 )
2017
6
Preoperative hypoalbuminemia is an independent risk factor for conversion from laparoscopic to open cholecystectomy in patients with cholecystolithiasis. ( 27283337 )
2016
7
Single-stage management with combined tri-endoscopic approach for concomitant cholecystolithiasis and choledocholithiasis. ( 27126621 )
2016
8
Intraoperative endoscopic nasobiliary drainage over primary closure of the common bile duct for choledocholithiasis combined with cholecystolithiasis: a cohort study of 211 cases. ( 27864721 )
2016
9
Endoscopic-Laparoscopic Cholecystolithotomy in Treatment of Cholecystolithiasis Compared With Traditional Laparoscopic Cholecystectomy. ( 27579981 )
2016
10
Endoscopic minimal invasive cholecystolithotomy vs laparoscopic cholecystectomy in treatment of cholecystolithiasis in China: a meta-analysis. ( 25527194 )
2015
11
Prospective multicentre cohort study of patient-reported outcomes after cholecystectomy for uncomplicated symptomatic cholecystolithiasis. ( 26201942 )
2015
12
Abdominal regional fat distribution on MRI correlates with cholecystolithiasis. ( 25310024 )
2014
13
Single-incision laparoscopic cholecystectomy for cholecystolithiasis coinciding with cavernous transformation of the portal vein: report of a case. ( 23578019 )
2013
14
Meta-analysis of laparoscopic versus open cholecystectomy for patients with liver cirrhosis and symptomatic cholecystolithiasis. ( 23034741 )
2013
15
The predictive value of pre-operative symptoms including upper gastrointestinal endoscopy before laparoscopic cholecystectomy for elective symptomatic cholecystolithiasis. ( 24899324 )
2013
16
A new strategy of minimally invasive surgery for cholecystolithiasis: calculi removal and gallbladder preservation. ( 24481280 )
2013
17
Symptomatic cholecystolithiasis after cholecystectomy. ( 23362056 )
2013
18
Dubin-Johnson syndrome with cholecystolithiasis and choledocholithiasis. ( 23708305 )
2013
19
Cholecystolithiasis after gastric bypass: a clinical, biochemical, and ultrasonographic 3-year follow-up study. ( 22767176 )
2012
20
Tiny cystine stones in the gallbladder of a patient with cholecystolithiasis complicating acute cholecystitis: a case report. ( 22472465 )
2012
21
Heterotopic pancreas in gall bladder associated with chronic cholecystolithiasis. ( 23776830 )
2012
22
Development of a real-time PCR assay for the detection of Clonorchis sinensis DNA in gallbladder bile and stone samples from patients with cholecystolithiasis. ( 22669695 )
2012
23
Cholecystolithiasis is associated with Clonorchis sinensis infection. ( 22905137 )
2012
24
Long-term outcome of endoscopic papillotomy for choledocholithiasis with cholecystolithiasis. ( 20447201 )
2010
25
Open, small-incision, or laparoscopic cholecystectomy for patients with symptomatic cholecystolithiasis. An overview of Cochrane Hepato-Biliary Group reviews. ( 20091665 )
2010
26
Systematic review: open, small-incision or laparoscopic cholecystectomy for symptomatic cholecystolithiasis. ( 19035965 )
2009
27
Randomized clinical trial of small-incision and laparoscopic cholecystectomy in patients with symptomatic cholecystolithiasis: primary and clinical outcomes. ( 18427025 )
2008
28
Prevalence of cholecystolithiasis and its management among kidney/pancreas-transplanted type 1 (insulin-dependent) diabetic patients. ( 18499558 )
2008
29
Effect of Lidan Granule on bile lithogenesis in patients with choledocholithiasis combined with cholecystolithiasis. ( 18679607 )
2008
30
Gastric emptying before and after cholecystectomy in patients with cholecystolithiasis. ( 18705281 )
2008
31
Randomized Clinical Trial of Small-Incision and Laparoscopic Cholecystectomy in Patients With Symptomatic Cholecystolithiasis: Primary and Clinical Outcomes-Invited Critique. ( 28715572 )
2008
32
Anaesthesiological considerations in small-incision and laparoscopic cholecystectomy in symptomatic cholecystolithiasis: implications for pulmonary function. A randomized clinical trial. ( 17697302 )
2007
33
Behavior of the common bile duct diameter before and 12 years after choledochostomy for cholecystolithiasis and choledocholithiasis. A prospective study. ( 17682828 )
2007
34
Laparoscopic versus small-incision cholecystectomy for patients with symptomatic cholecystolithiasis. ( 17054284 )
2006
35
Laparoscopic versus open cholecystectomy for patients with symptomatic cholecystolithiasis. ( 17054285 )
2006
36
Small-incision versus open cholecystectomy for patients with symptomatic cholecystolithiasis. ( 17054215 )
2006
37
Relation of gallbladder function and Helicobacter pylori infection to gastric mucosa inflammation in patients with symptomatic cholecystolithiasis. ( 16641551 )
2006
38
Acute biliary pancreatitis and cholecystolithiasis in a child: one time treatment with laparoendoscopic "rendez-vous" procedure. ( 16586553 )
2006
39
Gallstone disease: Surgical aspects of symptomatic cholecystolithiasis and acute cholecystitis. ( 17127186 )
2006
40
Current status of laparoscopic therapy of cholecystolithiasis and common bile duct stones. ( 16352891 )
2005
41
Bouveret's syndrome: a rare complication of cholecystolithiasis. ( 16174186 )
2005
42
Transforming growth factor-beta pathway is activated in cholecystolithiasis. ( 15702358 )
2005
43
Somatosensory changes in the referred pain area in patients with cholecystolithiasis. ( 16003137 )
2005
44
Detection of nanobacteria in serum, bile and gallbladder mucosa of patients with cholecystolithiasis. ( 15780215 )
2005
45
Short- versus long-sequence MRI cholangiography for the preoperative imaging of the common bile duct in patients with cholecystolithiasis. ( 16021379 )
2005
46
Segmental adenomyomatosis of the gallbladder predisposes to cholecystolithiasis. ( 15549435 )
2004
47
Medical image. Magnetic resonance cholangiopancreatography (MRCP) demonstrating cholecystolithiasis and aberrant pancreatic duct anatomy. ( 15326512 )
2004
48
Symptomatic cholecystolithiasis after laparoscopic cholecystectomy. ( 15106630 )
2004
49
Predictions and associations of cholecystectomy in patients with cholecystolithiasis treated with extracorporeal shock wave lithotripsy. ( 15628729 )
2004
50
Is drip infusion cholecystocholangiography (DIC) an acceptable modality at cholecystectomy for cholecystolithiasis, considering the frequency of bile duct maljunction and intraoperative bile duct injury? ( 15127278 )
2004

Variations for Cholecystolithiasis

Expression for Cholecystolithiasis

Search GEO for disease gene expression data for Cholecystolithiasis.

Pathways for Cholecystolithiasis

Pathways related to Cholecystolithiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.88 BMP6 TGFB1
2 10.44 BMP6 TGFB1

GO Terms for Cholecystolithiasis

Biological processes related to Cholecystolithiasis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.67 BMP6 CCK TGFB1
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.51 CCK TGFB1
3 cellular response to mechanical stimulus GO:0071260 9.48 BMP6 TGFB1
4 positive regulation of epithelial cell proliferation GO:0050679 9.46 BMP6 TGFB1
5 cell development GO:0048468 9.43 BMP6 TGFB1
6 regulation of MAPK cascade GO:0043408 9.4 BMP6 TGFB1
7 SMAD protein signal transduction GO:0060395 9.37 BMP6 TGFB1
8 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.32 BMP6 TGFB1
9 positive regulation of protein secretion GO:0050714 9.26 BMP6 TGFB1
10 positive regulation of bone mineralization GO:0030501 9.16 BMP6 TGFB1
11 positive regulation of SMAD protein signal transduction GO:0060391 8.96 BMP6 TGFB1
12 receptor catabolic process GO:0032801 8.62 TGFB1 UVRAG

Molecular functions related to Cholecystolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 8.62 BMP6 TGFB1

Sources for Cholecystolithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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