Choledocholithiasis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHL039 MIFTS: 38	Choledocholithiasis Categories: Gastrointestinal diseases, Liver diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Choledocholithiasis

MalaCards integrated aliases for Choledocholithiasis:

Name: Choledocholithiasis ¹² ⁵⁴ ⁴³ ¹⁵ ¹⁷ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:11755

MeSH ⁴³ D042883

EFO ¹⁷ EFO_1000865

UMLS ⁷¹ C0701818

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Summaries for Choledocholithiasis

MalaCards based summary : Choledocholithiasis is related to cholecystitis and peritonitis. An important gene associated with Choledocholithiasis is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways is Folate Metabolism. The drugs Midazolam and Meperidine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and pancreas.

Wikipedia : ⁷⁴ Common bile duct stone, also known as choledocholithiasis, is the presence of gallstones in the common... more...

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Related Diseases for Choledocholithiasis

Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 350)

#	Related Disease	Score	Top Affiliating Genes
1	cholecystitis	31.7	GUSB GPT F2 ALB
2	peritonitis	31.0	F2 CRP ALB
3	cholelithiasis	31.0	UGT1A1 GPT GGT1 CRP ALB ABCB4
4	pancreatitis	30.8	SLC17A5 GGT1 CRP ALB
5	hepatic coma	30.6	GPT F2 ALB
6	liver cirrhosis	30.4	SLC17A5 GPT GGT1 F2 ALB
7	extrahepatic cholestasis	30.4	GPT GGT1 ALPP ABCB4
8	hepatic encephalopathy	30.4	SLC17A5 GPT F2 ALB
9	obstructive jaundice	30.3	SLC17A5 GPT GGT1 F2 CRP ALPP
10	cholestasis	30.3	SLC17A5 GPT GGT1 F2 ALPP ALB
11	acute kidney failure	30.3	GPT F2 ALB
12	gilbert syndrome	30.3	UGT1A1 GPT ALB
13	suppurative cholangitis	30.2	GPT GGTLC3 GGT2 GGT1 ABCB4
14	ascending cholangitis	30.2	GPT GGTLC3 F2 CRP ALB
15	portal hypertension	30.2	GPT F2 ALB
16	thrombophlebitis	30.1	F2 CRP ALB
17	drug-induced hepatitis	30.1	UGT1A1 GPT F2 ALB
18	cholangitis	30.1	SLC17A5 GPT GGT1 F2 CRP CEACAM5
19	sickle cell anemia	30.1	UGT1A1 F2 CRP ALB
20	bronchopneumonia	30.0	GUSB GPT CRP ALB
21	acute cystitis	29.9	GPT F2 CRP ALB
22	cholecystolithiasis	29.9	STK10 GPT ERVMER34-1 CRP CEACAM5
23	hyperthyroidism	29.9	GPT CRP ALPP ALB
24	autoimmune hepatitis	29.8	SLC17A5 GPT GGT1 F2 ALB
25	bile duct cancer	29.8	PCCA GPT CEACAM5 ALB
26	respiratory failure	29.8	GPT F2 CRP ALB
27	intestinal obstruction	29.7	GPT CRP CEACAM5 ALB
28	sclerosing cholangitis	29.7	GPT GGT1 F2 CEACAM5 ALB ABCB4
29	fatty liver disease	29.7	SLC17A5 GPT GGT1 CRP ALB
30	acute cholangitis	29.7	GPT GGTLC3 GGT2 GGT1 F2 CRP
31	neutropenia	29.6	UGT1A1 GUSB GPT CRP ALB
32	deficiency anemia	29.6	GGTLC3 GGT2 GGT1 CRP ALB
33	klatskin's tumor	29.5	PCCA GPT CEACAM5 ALB
34	alcohol use disorder	29.4	SLC17A5 GPT GGTLC3 GGT2 GGT1 ALB
35	primary biliary cirrhosis	29.3	SLC17A5 GPT GGT1 F2 ALPP ALB
36	bile duct cysts	29.0	PCCA GPT GGTLC3 GGT2 GGT1 CEACAM5
37	liver disease	29.0	UGT1A1 SLC17A5 GPT GGT1 F2 ALPP
38	bilirubin metabolic disorder	28.8	UGT1A1 SLC17A5 GPT GGTLC3 GGT2 GGT1
39	gallbladder disease	28.6	UGT1A1 GPT GGTLC3 GGT2 GGT1 CRP
40	cholangitis, primary sclerosing	28.5	PCCA GPT GGTLC3 GGT2 GGT1 F2
41	biliary tract disease	28.3	PCCA GPT GGTLC3 GGT2 GGT1 F2
42	bile duct disease	27.8	PCCA GPT GGTLC3 GGT2 GGT1 F2
43	gallbladder disease 1	10.8
44	acute pancreatitis	10.7
45	paraquat poisoning	10.6	SLC17A5 GPT
46	dipetalonemiasis	10.6	GPT ALB
47	hepatoportal sclerosis	10.5	GPT F2
48	non-a-e hepatitis	10.5	F2 ALB
49	antipyrine metabolism	10.5	F2 ALB
50	heterophyiasis	10.5	GPT ALB

Graphical network of the top 20 diseases related to Choledocholithiasis:

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Symptoms & Phenotypes for Choledocholithiasis

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Drugs & Therapeutics for Choledocholithiasis

Drugs for Choledocholithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Meperidine

Approved

Phase 4

57-42-1

4058

Etomidate

Approved

Phase 4

33125-97-2

36339 667484

Ursodeoxycholic acid

Approved, Investigational

Phase 4

128-13-2

31401

Ceftriaxone

Approved

Phase 4

73384-59-5

5361919 5479530

Levofloxacin

Approved, Investigational

Phase 4

100986-85-4

149096

Ofloxacin

Approved

Phase 4

82419-36-1

4583

Hypnotics and Sedatives

Phase 4

Narcotics

Phase 4

Anti-Anxiety Agents

Phase 4

Anesthetics, General

Phase 4

Psychotropic Drugs

Phase 4

Analgesics, Opioid

Phase 4

Analgesics

Phase 4

GABA Modulators

Phase 4

Anesthetics, Intravenous

Phase 4

Neurotransmitter Agents

Phase 4

Gastrointestinal Agents

Phase 4

Anti-Bacterial Agents

Phase 4

Antibiotics, Antitubercular

Phase 4

Anti-Infective Agents

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Pharmaceutical Solutions

Phase 3

Chlorhexidine

Approved, Vet_approved

55-56-1

9552079 2713

Glucagon

Approved

16941-32-5

Indomethacin

Approved, Investigational

53-86-1

3715

Propofol

Approved, Investigational, Vet_approved

2078-54-8

4943

Cefotaxime

Approved

63527-52-6

5742673 456256

Cefoxitin

Approved

35607-66-0

441199

Scopolamine

Approved, Investigational

6533-68-2, 51-34-3

5184

Pancrelipase

Approved, Investigational

53608-75-6

Vitamin A

Approved, Nutraceutical, Vet_approved

22737-96-8, 68-26-8, 11103-57-4

9904001 445354

Tissue Plasminogen Activator

Early Phase 1

Plasminogen

Early Phase 1

Disinfectants

Chlorhexidine gluconate

Anti-Infective Agents, Local

Glucagon-Like Peptide 1

Anesthetics

Bilirubin

69853-43-6, 635-65-4

21252250 5280352

Cephalosporins

Butylscopolammonium Bromide

Retinol palmitate

retinol

Liver Extracts

pancreatin

Hemostatics

Interventional clinical trials:

(show top 50) (show all 72)

#	Name	Status	NCT ID	Phase	Drugs
1	Endoscopic Treatment of Difficult Bile Duct Stones: Use of Direct Visualization System ("Spyglass Direct Visualization System") Associated With Electrohydraulic Lithotripsy (EHL) X Hydrostatic Balloon Dilation of the Major Duodenal Papilla	Unknown status	NCT02703077	Phase 4
2	Etomidate With Meperidine vs Midazolam With Meperidine for Sedation During Endodscopic Retrograde Cholangiopancreatogram (ERCP)	Completed	NCT02027311	Phase 4	Etomidate;Midazolam;Meperidine
3	Studie Naar De Effectiviteit Van Ursodeoxycholzuur Ter Preventie Van Galsteen-Gerelateerde Klachten Bij patiënten in Afwachting Van Een Cholecystectomie	Completed	NCT00161083	Phase 4	ursodeoxycholic acid
4	Randomized Trial of Short Antibiotic Course to Decrease Post ERCP Cholangitis	Recruiting	NCT03087656	Phase 4	Ceftriaxone;Levofloxacin
5	Effect of Saline Irrigation to Decrease Rate of Residual Common Bile Duct Stones	Unknown status	NCT01425177	Phase 3
6	Endoscopic Sphincterotomy Plus Large-Balloon Dilatation (ESLBD) Versus Conventional Endoscopic Treatment for Removal of Large Common Bile Duct Stones : A Prospective Comparative Multi Center Randomized Study	Completed	NCT02592811	Phase 3
7	Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary Obstruction	Terminated	NCT01424657	Phase 3
8	The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis Showing the High Level of Aminotransferase and the Establishment of New Nomenclature ; Gallstone Hepatitis	Unknown status	NCT02647593
9	Laparoendoscopic Rendez Vous (Intraoperative ERCP) vs Two Stage Approach (Preoperative ERCP Followed by Laparoscopic Cholecystectomy) for the Management of Cholelithiasis/Choledocholithiasis	Unknown status	NCT00416234
10	Comparison of Endoscopic Papillary Balloon Dilatation and Sphincterotomy for CBD Stones With Difficult Sphincterotomy or Distal CBD Tapering	Unknown status	NCT00329888
11	A Prospective Randomized Multicenter Study Comparing Different Dilation Durations During Endoscopic Papillary Balloon Dilatation for Bile Duct Stones.	Unknown status	NCT00451581
12	Initial Cholecystectomy With Intraoperative Cholangiography for Patients at Intermediate Risk of Common Bile Duct Stone Migration : Prospective Validation and Analysis	Unknown status	NCT02461147
13	Clinical Study of Abdominal Drainage in Laparoscopic Common Bile Duct Exploration With Primary Closure	Unknown status	NCT03120754
14	Prospective Study of Bacteremia and Infection Rates Following Cholangioscopy With the Spyglass Cholangioscope	Unknown status	NCT01414400
15	Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope	Unknown status	NCT02276157
16	Gastrointestinal Microbiomes in Patients of Recurrent Common Bile Duct Stones After Endoscopic Sphincterotomy（EST）	Unknown status	NCT03102281
17	Prospective Randomized Clinical Study for Timing of Laparoscopic Cholecystectomy After Endoscopic Retrograde Cholangiography for Acute Biliary Pancreatitis	Unknown status	NCT01687959	Early Phase 1
18	Endoscopic Retrograde Cholangiopancreatography, Endoscopic Ultrasound and Interventional Endoscopy in Pancreatico-biliary, Gastrointestinal and Esophageal Disorders	Unknown status	NCT01438385
19	Prospective Evaluation of the Ability of Spyglass Cholangioscopy to Facilitate Radiation Free ERCP	Completed	NCT03074201
20	Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone	Completed	NCT00173368
21	A Randomized Controlled Trial Comparing Post-operative Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy	Completed	NCT01824186
22	Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD	Completed	NCT01673269
23	Effect of 8.5 F Plastic Stent Without Proximal Flap on Prevention of Post-ERCP Cholangitis on Patients With choledocholithiasis--a Prospective Randomized Trial	Completed	NCT02594891
24	Preoperative Versus Intraoperative Endoscopic Sphincterotomy for Management of Choledocholithiasis and Cholecystolithiasis	Completed	NCT01046552
25	Loop-tipped Guidewire in Selective Biliary Cannulation: a Prospective, Randomized, Controlled Trial	Completed	NCT02028845
26	The Laryngeal Mask Airway Supreme (TM) is an Effective Alternative to Laryngoscope-guided Tracheal Intubation for Patients Undergoing Elective Laparoscopic Cholecystectomy-- A Prospective Randomized Controlled Trial	Completed	NCT02037958
27	Routine Bile Collection for Microbiological Analysis During Cholangiography and Its Impact on Management of Cholangitis: Results of a Prospective Study	Completed	NCT01003782
28	Inmediate Feeding Tolerance in Patients With Mild and Acute Biliary Pancreatitis vs Early Feeding	Completed	NCT03354065
29	"Single Setting ERCP and Laparoscopic Cholecystectomy is a Safe Procedure in Patients With Cholecysto-Choledocholithiasis: A Prospective Study in a Peripheral-Level Hospital"	Completed	NCT04213092
30	Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones	Completed	NCT01683240
31	Success of Routine Intraoperative Cholangiography	Completed	NCT04052633
32	Laparoscopy-Assisted Transgastric Endoscopic Retrograde Cholangiopancreatography for Choledocholithiasis After Roux-en-Y Gastric Bypass	Completed	NCT03925766
33	Role of Complete Blood Picture in Predicting the Etiology of Extrahepatic Cholestasis	Completed	NCT03237247
34	A Prospective, Randomized Study Comparing Efficacy and Safety Between Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography	Completed	NCT02594475
35	Prospective Evaluation of Residual Bile Duct Stone Detection by Peroral Cholangioscopy That Is Missed With Conventional ERCP and Cholangiogram	Completed	NCT03482375
36	A Prospective Randomized Trial Comparing EUS Guided ERCP Without Fluoroscopy With Standard ERCP in Common Bile Duct Stone Removal	Completed	NCT02870686
37	Early Endoscopic Ultrasound (EUS) in Acute Biliary Pancreatitis: a Prospective Pilot Study	Completed	NCT02430285
38	ERCP in Super-aged Patients Considering Difficult Cannulation: Challenges and Adverse Events	Completed	NCT03771547
39	Prospective Randomized Trial of Laparoscopic Cholecystectomy Plus Laparoscopic Common Bile Duct Exploration (LC + LCBDE) Versus Endoscopic Retrograde Cholangiopancreatography Sphincterotomy Plus Laparoscopic Cholecystectomy (ERCP/S + LC) for Common Bile Duct Stone Disease	Completed	NCT00807729
40	Common Bile Duct Stone Management: What Have we Learned?	Completed	NCT02155244
41	Randomized Trial of Combination of Cholangioscopic Guided Laser Lithotripsy and Conventional Mechanical Versus Conventional Mechanical Methods for the Endoscopic Removal of Large Bile Duct Stones	Completed	NCT01759979
42	Cytological Evaluation of Biliary Epithelium After Previous Endoscopic Sphincterotomy for Benign Disease	Completed	NCT01135732
43	Ethical Committee at Researches of Ege University	Completed	NCT04410640
44	EPBD+Small EST VS. Large EST in Patients With Choledocholithiasis Complicated With Duodenal Papillary Diverticula	Recruiting	NCT04254887
45	Role of EUS in High Risk of Choledocholithiasis	Recruiting	NCT03250286
46	Division of Hepato-gastroenterology; Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,Taiwan	Recruiting	NCT03754491
47	Endosonography Versus Magnetic Resonance Cholangiopancreatography for Choledocholithiasis for Intermediate Risk of Choledocholithiasis (as Per European Society of Gastrointestinal Endoscopy Guidelines )- Randomized Controlled Trial	Recruiting	NCT04173624
48	Comparison of Two Management Strategies, "Endoscopy First" and "Laparoscopic Cholecystectomy First", for Patients With Gallbladder Stones and Intermediate Risk for Choledocholithiasis	Recruiting	NCT03658863
49	If Chronic Gallbladder Diseases Increase the Occurence of Post Endoscopic Retrograde Choledochopancreatography Choledocholithiasis（a Prospective Multi-center Cohort Study）	Recruiting	NCT04242394
50	Does the Gallbladder Status Influence the Occurence of Post-Endoscopic Retrograde Choledochopancreatography(ERCP) -Choledocholithiasis	Recruiting	NCT04234126

Search NIH Clinical Center for Choledocholithiasis

Cochrane evidence based reviews: choledocholithiasis

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Genetic Tests for Choledocholithiasis

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Anatomical Context for Choledocholithiasis

MalaCards organs/tissues related to Choledocholithiasis:

⁴⁰

Liver, Testes, Pancreas, Colon, Kidney, Heart, Bone

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Publications for Choledocholithiasis

Articles related to Choledocholithiasis:

(show top 50) (show all 3831)

#	Title	Authors	PMID	Year
1	Role of liver function tests in predicting common bile duct stones in acute calculous cholecystitis. ⁵⁴ ⁶¹	Peng WK...Nixon SJ	16078299	2005
2	Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis. ⁶¹ ⁵⁴	Nathwani RA...Kaplowitz N	15667485	2005
3	[Usefulness of endoscopic cholangiography and sphincterotomy in patients with biliary lithiasis]. ⁶¹ ⁵⁴	Ramirez-Luna MA...Valdovinos-Andraca F	15765973	2004
4	[Predictors of choledocholithiasis in patients sustaining gallstones]. ⁶¹ ⁵⁴	de Campos T...Pacheco Junior AM	15286869	2004
5	Lipopolysaccharides and beta-glucuronidase activity in choledochal bile in relation to choledocholithiasis. ⁶¹ ⁵⁴	Osnes T...Osnes M	9383634	1997
6	Increased intercellular adhesion molecule-1 serum concentration in cholestasis. ⁶¹ ⁵⁴	Polzien F...Ramadori G	9007716	1996
7	Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis. ⁶¹ ⁵⁴	Onken JE...Cotton PB	8677945	1996
8	Jaundice. ⁶¹ ⁵⁴	McKnight JT...Jones JE	1543099	1992
9	EUS-Directed Transgastric Endoscopic Retrograde Cholangiopancreatography (EDGE): The First Learning Curve. ⁶¹	Tyberg A...Kahaleh M	32149820	2020
10	Risk factors for complications after cholecystectomy for common bile duct stones: An EAST multicenter study. ⁶¹	Tracy BM...EAST Retained Common Bile Duct Stones Study Group	32466829	2020
11	Concomitant laparoscopic cholecystectomy and antegrade wire, rendezvous cannulation of the biliary tree may reduce post-ERCP pancreatitis events. ⁶¹	Winder JS...Pauli EM	31489502	2020
12	Usefulness of endoscopic nasobiliary drainage-guided ERCP in patients with surgically altered anatomy (with video). ⁶¹	Takano Y...Nagahama M	32490167	2020
13	A complex case of low-phospholipid-associated cholelithiasis syndrome. ⁶¹	Figueiredo LM...Martins A	32543870	2020
14	Choledocholithiasis in autosomal dominant polycystic kidney disease. ⁶¹	Sachdeva S...Dalal A	32553703	2020
15	Predicting common bile duct stones by non-invasive parameters. ⁶¹	Kadah A...Sbeit W	31810810	2020
16	A new variant of double common bile duct associated with choledochal cyst. ⁶¹	Nuamah NM...Sahiner IT	32577210	2020
17	Cost effectiveness of intraoperative laparoscopic ultrasound for suspected choledocholithiasis; outcomes from a specialist benign upper gastrointestinal unit. ⁶¹	Donoghue S...Andrews S	32538107	2020
18	Laparoscopic transcystic common bile duct exploration (LTCBDE): a safer method to treat common bile duct stones than laparoscopic choledochotomy. ⁶¹	Pang L...Kong J	32496116	2020
19	Unsual Aspect of a Choledocholithiasis. ⁶¹	Breidert M...Wildi S	32504640	2020
20	Differences between residual and primary choledocholithiasis in cholecystectomy patients. ⁶¹	Ruiz Pardo J...Valiente Carrillo J	32496117	2020
21	Unsuspected choledocholithiasis found by routine intra-operative cholangiography during laparoscopic cholecystectomy. ⁶¹	O'Neill RS...Hugh TJ	32536007	2020
22	Response to: Approach to evaluation of choledocholithiasis in patient with or without acute cholangitis. ⁶¹	Tan SY...Chong VH	32125414	2020
23	Acute cholecystitis and residual choledocholithiasis in a situs inversus patient, successful laparoscopic approach and ERCP a case report from Ecuador. ⁶¹	Moyon C MA...Vinueza ME	32426127	2020
24	Laparoendoscopic rendezvous versus ERCP followed by laparoscopic cholecystectomy for the management of cholecysto-choledocholithiasis: a retrospectively cohort study. ⁶¹	Qian Y...Sun Q	31428853	2020
25	Post-endoscopic retrograde cholangiopancreatography pancreatitis in single-stage endoscopic common bile duct stone removal. ⁶¹	Saito H...Matsushita I	32514443	2020
26	Endoscopic treatment of biliary complications after liver transplantation. ⁶¹	Lopez Alvarez M...Alonso Aguirre P	32543875	2020
27	Self-reported and actual adherence to the Tokyo guidelines in the European snapshot audit of complicated calculous biliary disease. ⁶¹	Bass GA...European Society for Trauma and Emergency Surgery (ESTES) Cohort Studies Group	32418332	2020
28	Laparoscopic management of type II Mirizzi syndrome. ⁶¹	Senra F...Martinez-Isla A	32140861	2020
29	Biloma: A Rare Manifestation of Spontaneous Bile Leak. ⁶¹	Yousaf MN...Sittambalam C	32542169	2020
30	Perioperative outcomes of the patients treated using laparoscopic cholecystectomy after emergent endoscopic retrograde cholangiopancreatography for bile duct stones: Does timing matter? ⁶¹	Senocak R...Hancerliogullari O	32436986	2020
31	Upper Gastrointestinal Bleeding With Hemobilia Caused by Gallstones. ⁶¹	Chang CW...Liu HL	32354592	2020
32	What constitutes urgent endoscopy? A social media snapshot of gastroenterologists' views during the COVID-19 pandemic. ⁶¹	Bilal M...Pleskow DK	32355889	2020
33	The Role of Laparoscopic Ultrasonography in the Evaluation of Suspected Choledocholithiasis. A Single-Center Experience. ⁶¹	Atstupens K...Pupelis G	32443814	2020
34	Laparoscopic trans-gastric endoscopic retrograde cholangiopancreatography during emergent cholecystectomy after Roux-en-Y gastric bypass: novel techniques for choledocholithiasis. ⁶¹	Papanikolas M...Niles N	31478330	2020
35	Three-day antibiotic treatment for acute cholangitis due to choledocholithiasis with successful biliary duct drainage: A single-center retrospective cohort study. ⁶¹	Satake M...Yamaguchi Y	32376307	2020
36	The effect of a simple simulator on the application of laparoscopic common bile duct exploration in a low volume center. ⁶¹	Lv Y...Li R	32456389	2020
37	One-stage laparoscopic procedure versus two-stage procedure in the management of common bile duct stones in patients aged 75 and more. ⁶¹	Gantois D...Balandraud P	31473141	2020
38	Partial protection with a chimeric tetraspanin-leucine aminopeptidase subunit vaccine against Opisthorchis viverrini infection in hamsters. ⁶¹	Thi Phung L...Laha T	31991114	2020
39	Clinical spotlight review for the management of choledocholithiasis. ⁶¹	Narula VK...SAGES Guidelines Committee	32095952	2020
40	Comparison of the safety and efficacy of single-stage endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy versus two-stage ERCP followed by laparoscopic cholecystectomy six-to-eight weeks later: A randomized controlled trial. ⁶¹	Muhammedoglu B...Kale IT	32105889	2020
41	What Can be Done for Large and Multiple Choledochal Stones? ⁶¹	Arslan U...Erdogdu UE	32513369	2020
42	A pictorial review of gall stones and its associated complications. ⁶¹	Gandhi D...Sharma P	31931279	2020
43	Alterations of the bile microbiome in primary sclerosing cholangitis. ⁶¹	Liwinski T...Schramm C	31243055	2020
44	Transductal versus transcystic laparoscopic common bile duct exploration: an institutional review of over four hundred cases. ⁶¹	Navaratne L...Martinez Isla A	32246237	2020
45	Ampullary stenosis and choledocholithiasis post Roux-En-Y gastric bypass: challenges of biliary access and intervention. ⁶¹	Wisneski AD...Corvera CU	32340857	2020
46	Laparoscopic common bile duct exploration for elderly patients with choledocholithiasis: a systematic review and meta-analysis. ⁶¹	Zhu J...Xiao W	32016517	2020
47	Implementation of a simplified self-releasing biliary stent in choledocholithiasis: Experience in 150 cases. ⁶¹	Yang J...Mao Z	31074126	2020
48	Novel Percutaneous Image Guided Treatment of Choledocholithiasis in a 30-day-old Infant. ⁶¹	Rajeswaran S...Mouli S	32304553	2020
49	Long-term outcomes and risk factors of recurrent biliary obstruction after permanent endoscopic biliary stenting for choledocholithiasis in high-risk patients. ⁶¹	Sugiura R...Sakamoto N	32223015	2020
50	Same anesthesia ERCP and laparoscopic cholecystectomy in the Pediatric ERCP Database Initiative (PEDI) Experience. ⁶¹	Fishman DS...Troendle DM	32304542	2020

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Genes for Choledocholithiasis

Genes related to Choledocholithiasis (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	19.25	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15765973 15286869 15667485
2	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	14.34	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15667485 8677945
3	ABCB4	ATP Binding Cassette Subfamily B Member 4	Protein Coding	12.46	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	GUSB	Glucuronidase Beta	Protein Coding	12.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9383634
5	ALB	Albumin	Protein Coding	12.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	F2	Coagulation Factor II, Thrombin	Protein Coding	12.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	11.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	10.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	1543099 16078299 9007716
9	ALPP	Alkaline Phosphatase, Placental	Protein Coding	10.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	LIX1	Limb And CNS Expressed 1	Protein Coding	6.71	DISEASES inferred ¹⁵
11	GGTLC3	Gamma-Glutamyltransferase Light Chain Family Member 3	Protein Coding	6.42	DISEASES inferred ¹⁵
12	GGT2	Gamma-Glutamyltransferase 2	Protein Coding	6.42	DISEASES inferred ¹⁵
13	CRP	C-Reactive Protein	Protein Coding	6.24	DISEASES inferred ¹⁵
14	SPATA20	Spermatogenesis Associated 20	Protein Coding	6.12	DISEASES inferred ¹⁵
15	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.99	DISEASES inferred ¹⁵
16	PCCA	Propionyl-CoA Carboxylase Subunit Alpha	Protein Coding	5.93	DISEASES inferred ¹⁵
17	STK10	Serine/Threonine Kinase 10	Protein Coding	5.88	DISEASES inferred ¹⁵
18	MIR302C	MicroRNA 302c	RNA Gene	5.79	DISEASES inferred ¹⁵
19	ERVMER34-1	Endogenous Retrovirus Group MER34 Member 1, Envelope	Protein Coding	5.78	DISEASES inferred ¹⁵

Sources

Variations for Choledocholithiasis

Sources

Expression for Choledocholithiasis

Search GEO for disease gene expression data for Choledocholithiasis.

Sources

Pathways for Choledocholithiasis

Pathways related to Choledocholithiasis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.35	GGT2 GGT1 F2 CRP ALB

Sources

GO Terms for Choledocholithiasis

Cellular components related to Choledocholithiasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.32	STK10 GUSB GPT GGTLC3 GGT2 GGT1

Biological processes related to Choledocholithiasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	acute-phase response	GO:0006953	9.43	UGT1A1 F2 CRP
2	regulation of immune system process	GO:0002682	9.32	GGT2 GGT1
3	peptide modification	GO:0031179	9.16	GGT2 GGT1
4	glutathione catabolic process	GO:0006751	9.13	GGTLC3 GGT2 GGT1
5	leukotriene D4 biosynthetic process	GO:1901750	8.8	GGTLC3 GGT2 GGT1

Molecular functions related to Choledocholithiasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidyltransferase activity	GO:0000048	8.96	GGT2 GGT1
2	glutathione hydrolase activity	GO:0036374	8.8	GGTLC3 GGT2 GGT1

Sources

Sources for Choledocholithiasis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia