MCID: CHL039
MIFTS: 37

Choledocholithiasis

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Choledocholithiasis

MalaCards integrated aliases for Choledocholithiasis:

Name: Choledocholithiasis 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11755
MeSH 45 D042883
SNOMED-CT 69 49910001
UMLS 74 C0701818

Summaries for Choledocholithiasis

MalaCards based summary : Choledocholithiasis is related to cholelithiasis and cholecystolithiasis. An important gene associated with Choledocholithiasis is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Midazolam and Meperidine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and lung.

Wikipedia : 77 Common bile duct stone, also known as choledocholithiasis, is the presence of gallstones in the common... more...

Related Diseases for Choledocholithiasis

Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 cholelithiasis 30.7 ABCB4 ALB GPT UGT1A1
2 cholecystolithiasis 30.5 ABCB4 STK10
3 cholangitis 30.5 ABCB4 ALB F2 GPT
4 cholecystitis 30.4 ABCB4 ALB F2 GPT
5 extrahepatic cholestasis 30.4 ABCB4 GPT
6 hepatitis 30.1 F2 GPT SLC17A5
7 sickle cell anemia 29.9 F2 UGT1A1
8 ascending cholangitis 29.9 ALB F2
9 biliary dyskinesia 29.8 SOBP STK10
10 liver cirrhosis 29.8 ALB F2 GPT SLC17A5
11 sclerosing cholangitis 29.8 ABCB4 ALB
12 cholangitis, primary sclerosing 29.7 ABCB4 ALB GPT
13 cholestasis 29.7 ABCB4 ALPP F2 GPT
14 portal hypertension 29.7 ALB F2 GPT
15 obstructive jaundice 29.6 ALB ALPP F2 GPT SLC17A5
16 infantile liver failure syndrome 1 29.4 ALB F2 GPT SLC17A5
17 pancreatitis 10.5
18 acute cholangitis 10.4
19 paraquat poisoning 10.3 GPT SLC17A5
20 pyridoxine deficiency 10.3 GPT SLC17A5
21 degos 'en cocarde' erythrokeratoderma 10.3
22 fatty liver disease, nonalcoholic 1 10.3 GPT SLC17A5
23 scrub typhus 10.3 GPT SLC17A5
24 hepatoportal sclerosis 10.3 F2 GPT
25 hepatitis d 10.2 F2 GPT
26 cholangiocarcinoma 10.2
27 legionnaires' disease 10.2 ALB SLC17A5
28 primary hepatic neuroendocrine carcinoma 10.1 ALPP GPT
29 protein-energy malnutrition 10.1 ALB GPT
30 antipyrine metabolism 10.1 ALB F2
31 non-a-e hepatitis 10.1 ALB F2
32 kernicterus 10.1 ALB UGT1A1
33 epstein-barr virus hepatitis 10.1 ALB F2
34 fournier gangrene 10.1 ALB F2
35 meningoencephalitis 10.1 ALB SLC17A5
36 abdominal tuberculosis 10.1 ALB F2
37 gallbladder disease 10.1 ABCB4 UGT1A1
38 splenic disease 10.1 ALB F2
39 esophageal varix 10.1 ALB F2
40 nonalcoholic steatohepatitis 10.1 F2 GPT SLC17A5
41 hypersplenism 10.1 ALB F2
42 hepatorenal syndrome 10.1 ALB F2
43 hepatic vascular disease 10.1 ALB F2
44 hellp syndrome 10.1 F2 GPT SLC17A5
45 pulmonary artery disease 10.1 ALB F2
46 acute pancreatitis 10.1
47 dysfibrinogenemia 10.1 ALB F2
48 vein disease 10.0 ALB F2
49 intermittent claudication 10.0 ALB F2
50 typhoid fever 10.0 ALB F2

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to Choledocholithiasis

Symptoms & Phenotypes for Choledocholithiasis

Drugs & Therapeutics for Choledocholithiasis

Drugs for Choledocholithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
2
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
3
Etomidate Approved Phase 4 33125-97-2 36339 667484
4
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
5 Anesthetics Phase 4,Not Applicable
6 Central Nervous System Depressants Phase 4
7 Peripheral Nervous System Agents Phase 4
8 Analgesics, Opioid Phase 4
9 Psychotropic Drugs Phase 4
10 Neurotransmitter Agents Phase 4
11 Anesthetics, Intravenous Phase 4
12 Narcotics Phase 4
13 Anti-Anxiety Agents Phase 4
14 Adjuvants, Anesthesia Phase 4
15 GABA Modulators Phase 4
16 Analgesics Phase 4
17 Anesthetics, General Phase 4
18 GABA Agents Phase 4
19 Hypnotics and Sedatives Phase 4
20 Tranquilizing Agents Phase 4
21 Gastrointestinal Agents Phase 4
22 Cholagogues and Choleretics Phase 4
23 Pharmaceutical Solutions Phase 3
24
Glucagon Approved Not Applicable 16941-32-5
25
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
26
Scopolamine Approved, Investigational Not Applicable 6533-68-2, 51-34-3 5184
27
Indomethacin Approved, Investigational Not Applicable 53-86-1 3715
28
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
29
Cefoxitin Approved Not Applicable 35607-66-0 441199
30
Cefotaxime Approved Not Applicable 63527-52-6 456256 5742673
31
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
32 Plasminogen Inactivators Early Phase 1
33 Tissue Plasminogen Activator Early Phase 1
34 Plasminogen Early Phase 1
35 Plasminogen Activator Inhibitor 1 Early Phase 1
36 Glucagon-Like Peptide 1 Not Applicable
37 Anti-Infective Agents, Local Not Applicable
38 Chlorhexidine gluconate Not Applicable
39 Anti-Infective Agents Not Applicable
40 Disinfectants Not Applicable
41 Anti-Bacterial Agents ,Not Applicable
42 Antibiotics, Antitubercular ,Not Applicable
43 Butylscopolammonium Bromide Not Applicable
44 pancreatin Not Applicable
45 retinol Not Applicable
46 Retinol palmitate Not Applicable
47 Antitubercular Agents Not Applicable
48 Cephalosporins Not Applicable
49 Liver Extracts Not Applicable

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
2 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
3 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
4 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
5 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
6 Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary Obstruction Terminated NCT01424657 Phase 3
7 Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234 Not Applicable
8 The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis Unknown status NCT02647593
9 A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation Unknown status NCT00451581 Not Applicable
10 Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering Unknown status NCT00329888
11 Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope Unknown status NCT02276157
12 Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatography). Unknown status NCT01414400 Not Applicable
13 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147
14 Timing of Laparoscopic Cholecystectomy After Endoscopic Retrograde Cholangiography for Acute Biliary Pancreatitis Unknown status NCT01687959 Early Phase 1
15 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Unknown status NCT01438385
16 Los Angeles Prospective GI Biliary and EUS Series Unknown status NCT02196935
17 Laser Versus Mechanical Lithotripsy of Bile Duct Stones Completed NCT01759979 Not Applicable
18 Prospective Evaluation of the Ability of Spyglass Cholangioscopy to Facilitate Radiation Free ERCP Completed NCT03074201 Not Applicable
19 Randomized Trial of ERCP Then Laparoscopic Cholecystectomy vs. Laparoscopic Cholecystectomy Plus Laparoscopic Common Bile Duct Exploration in Patients With Likely Choledocholithiasis Completed NCT00807729 Not Applicable
20 EUS Guided ERCP in Bile Duct Stone Removal Completed NCT02870686 Not Applicable
21 Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography Completed NCT02594475 Not Applicable
22 Effect of 8.5 F Plastic Stent Without Proximal Flap on Prevention of Post-ERCP Cholangitis Completed NCT02594891 Not Applicable
23 Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone Completed NCT00173368
24 Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy Completed NCT02037958 Not Applicable
25 Comparison Between Pre and Intraoperative ERCP in Treatment of Common Bile Duct Stones Completed NCT01046552 Not Applicable
26 Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD Completed NCT01673269 Not Applicable
27 Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones Completed NCT01683240 Not Applicable
28 Prospective Evaluation of Residual Bile Duct Stone by Peroral Cholangioscopy After Conventional ERCP Completed NCT03482375
29 Loop-tipped Guidewire in Selective Biliary Cannulation Completed NCT02028845 Not Applicable
30 ERCP in Super-aged Patients Considering Difficult Cannulation: Challenges and Adverse Events Completed NCT03771547
31 Early EUS in Acute Biliary Pancreatitis Completed NCT02430285 Not Applicable
32 Routine Bile Collection for Microbiological Analysis During Cholangiography Completed NCT01003782
33 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
34 Acute Biliary Pancreatitis - Optimal Time for Cholecystectomy Completed NCT03085407 Not Applicable
35 Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy Completed NCT01824186 Not Applicable
36 Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis Completed NCT02781987
37 Role of EUS in High Risk of Choledocholithiasis Recruiting NCT03250286 Not Applicable
38 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474 Not Applicable
39 "Endoscopy First" or "Laparoscopic Cholecystectomy First" for Patients With Intermediate Risk of Choledocholithiasis Recruiting NCT03658863 Not Applicable
40 The Comparisons of One-stage and Two-stage Stone Removal in Moderate Cholangitis Recruiting NCT03754491 Not Applicable
41 Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP Recruiting NCT02611453 Not Applicable
42 Papillary Balloon Dilation Versus Laser Lithotripsy Recruiting NCT03536247 Not Applicable
43 Microbiomes in Patients of Recurrent Common Bile Duct Stones Recruiting NCT03102281
44 Long-duration EPBD vs EST for Removal of Biliary Stones Recruiting NCT03683485 Not Applicable
45 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Recruiting NCT02958059 Not Applicable
46 Non-Complex Biliary Stones DSC vs ERC Recruiting NCT03421340 Not Applicable
47 Chinese Registry Study on Treatment of Cholecysto-Choledocholithiasis Active, not recruiting NCT02554097
48 A Prospective Study of Treating Duodenal Papillary Sphincter in Different Ways During ERCP Enrolling by invitation NCT03416205 Not Applicable
49 Early MRI in Acute GallstonE Disease Not yet recruiting NCT03709030 Not Applicable
50 Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients Terminated NCT00612846 Not Applicable

Search NIH Clinical Center for Choledocholithiasis

Cochrane evidence based reviews: choledocholithiasis

Genetic Tests for Choledocholithiasis

Anatomical Context for Choledocholithiasis

MalaCards organs/tissues related to Choledocholithiasis:

42
Liver, Testes, Lung, Colon, Heart, Thyroid

Publications for Choledocholithiasis

Articles related to Choledocholithiasis:

(show top 50) (show all 959)
# Title Authors Year
1
COMPARATIVE EVALUATION OF MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY AND PERIOPERATIVE CHOLANGIOGRAPHY IN PATIENTS WITH SUSPECT CHOLEDOCHOLITHIASIS. ( 30624525 )
2019
2
Single-Stage Endoscopic Stone Extraction and Cholecystectomy during the Same Hospitalization: What is the Optimal Strategy for Patients with Choledocholithiasis and Cholelithiasis? ( 30625266 )
2019
3
External Validation of Different Scoring Systems for Suspected Choledocholithiasis. ( 30636244 )
2019
4
Laparoscopic cholecystectomy after endoscopic treatment of choledocholithiasis: a retrospective comparative study. ( 30644060 )
2019
5
Combination of serum gamma-glutamyltransferase and alkaline phosphatase in predicting the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis. ( 30705891 )
2019
6
Use of intraoperative cholangiography in patients diagnosed with choledocholithiasis with preoperative imaging or endoscopic study. ( 30768067 )
2019
7
Role of Cholecystectomy in Choledocholithiasis Patients Underwent Endoscopic Retrograde Cholangiopancreatography. ( 30778100 )
2019
8
Sphincterotomy plus balloon dilation versus sphincterotomy alone for choledocholithiasis: a meta-analysis. ( 30786316 )
2019
9
Choledocholithiasis treated with a pediatric duodenoscope in a neonate. ( 30803055 )
2019
10
Epidemiology and disease characteristics of symptomatic choledocholithiasis in Sri Lanka. ( 30863806 )
2019
11
Pancreaticopleural fistula associated with choledocholithiasis: An infrequent complication of acute pancreatitis. ( 29530342 )
2018
12
Laparoscopic common bile duct exploration versus endoscopic retrograde cholangiopancreatography for choledocholithiasis found at time of laparoscopic cholecystectomy. ( 29477230 )
2018
13
Performance of the Choledocholithiasis Diagnostic Score in Patients with Acute Cholecystitis. ( 29457047 )
2018
14
Gallstone Pancreatitis and Choledocholithiasis: Using Imaging and Laboratory Trends to Predict the Likelihood of Persistent Stones at Cholangiography. ( 29626246 )
2018
15
Laparoscopic Common Bile Duct Exploration for Choledocholithiasis: Analysis of Practice Patterns of Intermountain HealthCare. ( 29518526 )
2018
16
Physicians infrequently miss choledocholithiasis prior to cholecystectomy in the United States. ( 29208548 )
2018
17
Successful endoscopic sphincterotomy for choledocholithiasis in a patient with severe hemophilia A and inhibitors. ( 29396835 )
2018
18
Outcomes Associated With Timing of ERCP in Acute Cholangitis Secondary to Choledocholithiasis. ( 29356786 )
2018
19
The Safety and Efficacy of Laparoscopic Common Bile Duct Exploration Combined with Cholecystectomy for the Management of Cholecysto-choledocholithiasis: An Up-to-date Meta-analysis. ( 29533266 )
2018
20
Risk assessment of choledocholithiasis prior to laparoscopic cholecystectomy and its management options. ( 29774157 )
2018
21
Impact of Jaundice on Outcomes Following Emergency Laparoscopic Cholecystectomy in Patients with Choledocholithiasis. ( 29541824 )
2018
22
Cholelithiasis and choledocholithiasis in children; risk factors for development. ( 29763444 )
2018
23
Electrohydraulic lithotripsy under double-balloon endoscope-assistedA direct cholangioscopy for treatmentA ofA choledocholithiasis in a patient with Roux-en-YA gastrectomy. ( 29916492 )
2018
24
Hemodialysis is a strong risk factor for post-endoscopic sphincterotomy bleeding in patients with choledocholithiasis. ( 29756014 )
2018
25
Role of Cholecystectomy After Endoscopic Sphincterotomy in the Management of Choledocholithiasis in High-risk Patients: A Systematic Review and Meta-Analysis. ( 29912758 )
2018
26
Nonsurgical management of an extensive spontaneous spinal epidural hematoma causing quadriplegia and respiratory distress in a choledocholithiasis patient: A case report: Erratum. ( 29369212 )
2018
27
Predictors for choledocholithiasis in patients undergoing endoscopic ultrasound. ( 29979088 )
2018
28
Pearl-White Gallstones Causing Choledocholithiasis. ( 29392151 )
2018
29
Single-stage laparoscopic management of choledocholithiasis: An analysis after implementation of a mastery learning resident curriculum. ( 29191675 )
2018
30
Various approaches of laparoscopic common bile duct exploration plus primary duct closure for choledocholithiasis: A systematic review and meta-analysis. ( 29627156 )
2018
31
Micro-Incision of the Cystic Duct Confluence in Laparoscopic Common Bile Duct Exploration for Elderly Patients with Choledocholithiasis. ( 29973752 )
2018
32
Management of endoscopic biliary stenting for choledocholithiasis: Evaluation of stent-exchange intervals. ( 29375741 )
2018
33
Safety and Efficacy of Endoscopic Retrograde Cholangiopancreatography for Choledocholithiasis in Long-Term Dialysis: A Propensity Score Analysis. ( 29767390 )
2018
34
Human fibrin sealant reduces post-operative bile leakage of primary closure after laparoscopic common bile duct exploration in patients with choledocholithiasis. ( 29974875 )
2018
35
The added value of tomosynthesis in endoscopic retrograde cholangiography with radiography for the detection of choledocholithiasis. ( 29630390 )
2018
36
Catheter probe extraductal ultrasound (EDUS) exploration of the common bile duct is safe in elderly patients with suspicion of choledocholithiasis after distal gastrectomy. ( 29600432 )
2018
37
Efficacy and Safety of Single-Session Endoscopic Stone Removal for Acute Cholangitis Associated with Choledocholithiasis. ( 30175087 )
2018
38
Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis. ( 30294608 )
2018
39
Preoperative predictors of choledocholithiasis in patients presenting with acute calculous cholecystitis. ( 30465770 )
2018
40
Two Cases of Acute Cholecystitis and Symptomatic Choledocholithiasis in Two Women Less than 40-Years-of-Age with Hormonal Intrauterine Devices. ( 30584481 )
2018
41
Inpatient Choledocholithiasis Requiring ERCP and Cholecystectomy: Outcomes of a Combined Single Inpatient Procedure Versus Separate-Session Procedures. ( 28971298 )
2018
42
Comparative Study of Three Bile Duct Closure Methods Following Laparoscopic Common Bile Duct Exploration for Choledocholithiasis. ( 28976804 )
2018
43
Choledocholithiasis in Roux-en-Y gastric bypass patients. ( 29453381 )
2018
44
Once upon a Time a Guideline Was Used for the Evaluation of Suspected Choledocholithiasis: A Fairy Tale or a Nightmare? ( 29457044 )
2018
45
Association Between Juxtapapillary Duodenal Diverticula and Risk of Choledocholithiasis: a Systematic Review and Meta-analysis. ( 30022443 )
2018
46
In-Hospital Pediatric ERCP is Associated with Shorter Hospitalization for Children with Choledocholithiasis. ( 30044307 )
2018
47
Single-stage management of cholelithiasis and choledocholithiasis: Laparoscopic cholecystectomy and intra-operative endoscopic sphincterotomy (with video). ( 30072276 )
2018
48
Self-expandable metal stents for choledocholithiasis in Billroth II gastrectomy patients. ( 30126827 )
2018
49
The reasonable drainage option after laparoscopic common bile duct exploration for the treatment of choledocholithiasis. ( 30145281 )
2018
50
Percutaneous Transcholecystic Management of Choledocholithiasis: A Next Horizon for Interventional Radiologists? ( 30226458 )
2018

Variations for Choledocholithiasis

Expression for Choledocholithiasis

Search GEO for disease gene expression data for Choledocholithiasis.

Pathways for Choledocholithiasis

Pathways related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 ALB F2

GO Terms for Choledocholithiasis

Cellular components related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.1 ABCB4 ALB F2 GPT GUSB STK10

Biological processes related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.62 F2 UGT1A1

Molecular functions related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT

Sources for Choledocholithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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