MCID: CHL039
MIFTS: 34

Choledocholithiasis

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Choledocholithiasis

MalaCards integrated aliases for Choledocholithiasis:

Name: Choledocholithiasis 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11755
MeSH 45 D042883
SNOMED-CT 69 49910001
UMLS 74 C0701818

Summaries for Choledocholithiasis

MalaCards based summary : Choledocholithiasis is related to cholelithiasis and cholangitis. An important gene associated with Choledocholithiasis is GPT (Glutamic--Pyruvic Transaminase). The drugs Midazolam and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and lung.

Wikipedia : 77 Common bile duct stone, also known as choledocholithiasis, is the presence of gallstones in the common... more...

Related Diseases for Choledocholithiasis

Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 cholelithiasis 10.7
2 cholangitis 10.6
3 cholecystitis 10.5
4 pancreatitis 10.5
5 acute cholangitis 10.4
6 cholecystolithiasis 10.3
7 degos 'en cocarde' erythrokeratoderma 10.3
8 gallbladder disease 1 10.3
9 obstructive jaundice 10.3
10 cholangiocarcinoma 10.2
11 cholestasis 10.1
12 ascaris lumbricoides infection 10.1
13 liver cirrhosis 10.1
14 acute pancreatitis 10.1
15 ascaridiasis 10.1
16 biliary dyskinesia 10.1
17 hepatocellular carcinoma 10.0
18 sickle cell anemia 10.0
19 langerhans cell histiocytosis 10.0
20 hepatitis 10.0
21 optic papillitis 10.0
22 quadriplegia 10.0
23 extrahepatic cholestasis 10.0
24 suppurative cholangitis 10.0
25 histiocytosis 10.0
26 sickle cell disease 10.0
27 pfeiffer syndrome 9.8
28 factor viii deficiency 9.8
29 gilbert syndrome 9.8
30 cholestasis, intrahepatic, of pregnancy, 1 9.8
31 pernicious anemia 9.8
32 protoporphyria, erythropoietic, 1 9.8
33 varicose veins 9.8
34 duodenal atresia 9.8
35 gastroschisis 9.8
36 dubin-johnson syndrome 9.8
37 graves disease 1 9.8
38 hemophilia a 9.8
39 myocardial infarction 9.8
40 aplastic anemia 9.8
41 cholangitis, primary sclerosing 9.8
42 meconium ileus 9.8
43 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.8
44 infantile liver failure syndrome 1 9.8
45 crohn's disease 9.8
46 lymphoma 9.8
47 thrombosis 9.8
48 intrahepatic cholestasis of pregnancy 9.8
49 portal hypertension 9.8
50 polyneuropathy 9.8

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to Choledocholithiasis

Symptoms & Phenotypes for Choledocholithiasis

Drugs & Therapeutics for Choledocholithiasis

Drugs for Choledocholithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
2
Etomidate Approved Phase 4 33125-97-2 667484 36339
3
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
4
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
5 GABA Modulators Phase 4
6 Anti-Anxiety Agents Phase 4
7 Narcotics Phase 4
8 Peripheral Nervous System Agents Phase 4
9 Anesthetics, General Phase 4
10 Analgesics Phase 4
11 Central Nervous System Depressants Phase 4
12 Neurotransmitter Agents Phase 4
13 Analgesics, Opioid Phase 4
14 Adjuvants, Anesthesia Phase 4
15 Psychotropic Drugs Phase 4
16 Anesthetics, Intravenous Phase 4
17 Tranquilizing Agents Phase 4
18 Anesthetics Phase 4,Not Applicable
19 Hypnotics and Sedatives Phase 4
20 GABA Agents Phase 4
21 Gastrointestinal Agents Phase 4
22 Cholagogues and Choleretics Phase 4
23 Pharmaceutical Solutions Phase 3
24
Glucagon Approved Not Applicable 16941-32-5
25
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
26
Scopolamine Approved, Investigational Not Applicable 51-34-3, 6533-68-2 5184
27
Indomethacin Approved, Investigational Not Applicable 53-86-1 3715
28
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
29
Cefotaxime Approved Not Applicable 63527-52-6 5742673 456256
30
Cefoxitin Approved Not Applicable 35607-66-0 441199
31
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
32 Plasminogen Activator Inhibitor 1 Early Phase 1
33 Plasminogen Early Phase 1
34 Plasminogen Inactivators Early Phase 1
35 Tissue Plasminogen Activator Early Phase 1
36 Glucagon-Like Peptide 1 Not Applicable
37 Anti-Infective Agents Not Applicable
38 Anti-Infective Agents, Local Not Applicable
39 Chlorhexidine gluconate Not Applicable
40 Disinfectants Not Applicable
41 Anti-Bacterial Agents ,Not Applicable
42 Antibiotics, Antitubercular ,Not Applicable
43 Butylscopolammonium Bromide Not Applicable
44 pancreatin Not Applicable
45 retinol Not Applicable
46 Retinol palmitate Not Applicable
47 Antitubercular Agents Not Applicable
48 Cephalosporins Not Applicable
49 Liver Extracts Not Applicable

Interventional clinical trials:

(show top 50) (show all 56)
# Name Status NCT ID Phase Drugs
1 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
2 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
3 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
4 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
5 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
6 Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary Obstruction Terminated NCT01424657 Phase 3
7 Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234 Not Applicable
8 The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis Unknown status NCT02647593
9 A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation Unknown status NCT00451581 Not Applicable
10 Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering Unknown status NCT00329888
11 Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope Unknown status NCT02276157
12 Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatography). Unknown status NCT01414400 Not Applicable
13 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147
14 Timing of Laparoscopic Cholecystectomy After Endoscopic Retrograde Cholangiography for Acute Biliary Pancreatitis Unknown status NCT01687959 Early Phase 1
15 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Unknown status NCT01438385
16 Laser Versus Mechanical Lithotripsy of Bile Duct Stones Completed NCT01759979 Not Applicable
17 Prospective Evaluation of the Ability of Spyglass Cholangioscopy to Facilitate Radiation Free ERCP Completed NCT03074201 Not Applicable
18 Randomized Trial of ERCP Then Laparoscopic Cholecystectomy vs. Laparoscopic Cholecystectomy Plus Laparoscopic Common Bile Duct Exploration in Patients With Likely Choledocholithiasis Completed NCT00807729 Not Applicable
19 EUS Guided ERCP in Bile Duct Stone Removal Completed NCT02870686 Not Applicable
20 Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography Completed NCT02594475 Not Applicable
21 Effect of 8.5 F Plastic Stent Without Proximal Flap on Prevention of Post-ERCP Cholangitis Completed NCT02594891 Not Applicable
22 Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone Completed NCT00173368
23 Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy Completed NCT02037958 Not Applicable
24 Laparoscopy-Assisted Transgastric ERCP Completed NCT03925766
25 Comparison Between Pre and Intraoperative ERCP in Treatment of Common Bile Duct Stones Completed NCT01046552 Not Applicable
26 Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD Completed NCT01673269 Not Applicable
27 Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones Completed NCT01683240 Not Applicable
28 Prospective Evaluation of Residual Bile Duct Stone by Peroral Cholangioscopy After Conventional ERCP Completed NCT03482375
29 Loop-tipped Guidewire in Selective Biliary Cannulation Completed NCT02028845 Not Applicable
30 Early EUS in Acute Biliary Pancreatitis Completed NCT02430285 Not Applicable
31 ERCP in Super-aged Patients Considering Difficult Cannulation: Challenges and Adverse Events Completed NCT03771547
32 Routine Bile Collection for Microbiological Analysis During Cholangiography Completed NCT01003782
33 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
34 Acute Biliary Pancreatitis - Optimal Time for Cholecystectomy Completed NCT03085407 Not Applicable
35 Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy Completed NCT01824186 Not Applicable
36 Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis Completed NCT02781987
37 Role of EUS in High Risk of Choledocholithiasis Recruiting NCT03250286 Not Applicable
38 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474 Not Applicable
39 "Endoscopy First" or "Laparoscopic Cholecystectomy First" for Patients With Intermediate Risk of Choledocholithiasis Recruiting NCT03658863 Not Applicable
40 The Comparisons of One-stage and Two-stage Stone Removal in Moderate Cholangitis Recruiting NCT03754491 Not Applicable
41 Effect of Saline Irrigation in Reducing Choledocholithiasis Recurrence After ERCP Recruiting NCT03937037 Not Applicable
42 Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP Recruiting NCT02611453 Not Applicable
43 Papillary Balloon Dilation Versus Laser Lithotripsy Recruiting NCT03536247 Not Applicable
44 Microbiomes in Patients of Recurrent Common Bile Duct Stones Recruiting NCT03102281
45 Long-duration EPBD vs EST for Removal of Biliary Stones Recruiting NCT03683485 Not Applicable
46 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Recruiting NCT02958059 Not Applicable
47 Los Angeles Prospective GI Biliary and EUS Series Recruiting NCT02196935
48 Non-Complex Biliary Stones DSC vs ERC Recruiting NCT03421340 Not Applicable
49 Chinese Registry Study on Treatment of Cholecysto-Choledocholithiasis Active, not recruiting NCT02554097
50 A Prospective Study of Treating Duodenal Papillary Sphincter in Different Ways During ERCP Enrolling by invitation NCT03416205 Not Applicable

Search NIH Clinical Center for Choledocholithiasis

Cochrane evidence based reviews: choledocholithiasis

Genetic Tests for Choledocholithiasis

Anatomical Context for Choledocholithiasis

MalaCards organs/tissues related to Choledocholithiasis:

42
Liver, Testes, Lung, Colon, Heart, Thyroid, Bone Marrow

Publications for Choledocholithiasis

Articles related to Choledocholithiasis:

(show top 50) (show all 966)
# Title Authors Year
1
Combination of serum gamma-glutamyltransferase and alkaline phosphatase in predicting the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis. ( 30705891 )
2019
2
Preoperative predictors of choledocholithiasis in patients presenting with acute calculous cholecystitis. ( 30465770 )
2019
3
A successful combined laparoscopic cholecystectomy and laparoscopic exploration of common bile duct for acute gangrenous cholecystitis and choledocholithiasis during pregnancy: A case report. ( 30991195 )
2019
4
Pancreaticopleural fistula associated with choledocholithiasis: An infrequent complication of acute pancreatitis. ( 29530342 )
2019
5
In-hospital Pediatric Endoscopic Retrograde Cholangiopancreatography Is Associated With Shorter Hospitalization for Children With Choledocholithiasis. ( 30044307 )
2019
6
Percutaneous Transcholecystic Management of Choledocholithiasis: A Next Horizon for Interventional Radiologists? ( 30226458 )
2019
7
ASGE high-risk criteria for choledocholithiasis - Are they applicable in cholecystectomized patients? ( 30366810 )
2019
8
COMPARATIVE EVALUATION OF MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY AND PERIOPERATIVE CHOLANGIOGRAPHY IN PATIENTS WITH SUSPECT CHOLEDOCHOLITHIASIS. ( 30624525 )
2019
9
Single-Stage Endoscopic Stone Extraction and Cholecystectomy during the Same Hospitalization: What is the Optimal Strategy for Patients with Choledocholithiasis and Cholelithiasis? ( 30625266 )
2019
10
External Validation of Different Scoring Systems for Suspected Choledocholithiasis. ( 30636244 )
2019
11
Laparoscopic cholecystectomy after endoscopic treatment of choledocholithiasis: a retrospective comparative study. ( 30644060 )
2019
12
Use of intraoperative cholangiography in patients diagnosed with choledocholithiasis with preoperative imaging or endoscopic study. ( 30768067 )
2019
13
Role of Cholecystectomy in Choledocholithiasis Patients Underwent Endoscopic Retrograde Cholangiopancreatography. ( 30778100 )
2019
14
Sphincterotomy plus balloon dilation versus sphincterotomy alone for choledocholithiasis: a meta-analysis. ( 30786316 )
2019
15
Choledocholithiasis treated with a pediatric duodenoscope in a neonate. ( 30803055 )
2019
16
Epidemiology and disease characteristics of symptomatic choledocholithiasis in Sri Lanka. ( 30863806 )
2019
17
Biliary Ascariasis Mimicking as Choledocholithiasis on Endoscopic Ultrasound. ( 30935184 )
2019
18
Transjejunal Laparoscopic-Assisted ERCP: a Technique to Deal with Choledocholithiasis After Roux-En-Y Reconstruction. ( 30972636 )
2019
19
ASGE guideline on the role of endoscopy in the evaluation and management of choledocholithiasis. ( 30979521 )
2019
20
Choledocholithiasis recurrence following laparoscopic common bile duct exploration. ( 31027833 )
2019
21
Accuracy and timeliness of an abbreviated emergency department MRCP protocol for choledocholithiasis. ( 31030393 )
2019
22
Management of choledocholithiasis by direct cholangioscopy via freehand intubation using the "J" maneuver. ( 31061942 )
2019
23
Implementation of a simplified self-releasing biliary stent in choledocholithiasis: Experience in 150 cases. ( 31074126 )
2019
24
Endoscopic retrograde cholangiopancreatography versus surgery for choledocholithiasis - A meta-analysis. ( 31080054 )
2019
25
Efficacy and Safety of Single-Session Endoscopic Stone Removal for Acute Cholangitis Associated with Choledocholithiasis. ( 30175087 )
2018
26
Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis. ( 30294608 )
2018
27
Percutaneous transcystic balloon dilation for common bile duct stone removal in high-surgical-risk patients with acute cholecystitis and co-existing choledocholithiasis. ( 29146469 )
2018
28
A prospective evaluation of radiation-free direct solitary cholangioscopy for the management of choledocholithiasis. ( 28797911 )
2018
29
Cost analysis of robot-assisted choledochotomy and common bile duct exploration as an option for complex choledocholithiasis. ( 28812193 )
2018
30
Inpatient Choledocholithiasis Requiring ERCP and Cholecystectomy: Outcomes of a Combined Single Inpatient Procedure Versus Separate-Session Procedures. ( 28971298 )
2018
31
Performance of the Choledocholithiasis Diagnostic Score in Patients with Acute Cholecystitis. ( 29457047 )
2018
32
Two Cases of Acute Cholecystitis and Symptomatic Choledocholithiasis in Two Women Less than 40-Years-of-Age with Hormonal Intrauterine Devices. ( 30584481 )
2018
33
Outcomes Associated With Timing of ERCP in Acute Cholangitis Secondary to Choledocholithiasis. ( 29356786 )
2018
34
Temporal trends in utilization and outcomes of endoscopic retrograde cholangiopancreatography in acute cholangitis due to choledocholithiasis from 1998 to 2012. ( 28917018 )
2018
35
Comparative Study of Three Bile Duct Closure Methods Following Laparoscopic Common Bile Duct Exploration for Choledocholithiasis. ( 28976804 )
2018
36
A predictive nomogram to identify factors influencing the success of a concomitant laparoscopic cholecystectomy with common bile duct exploration for choledocholithiasis. ( 29100711 )
2018
37
Pneumomediastinum and pneumoperitoneum following partial sphincterotomy for choledocholithiasis. ( 29110134 )
2018
38
Single-stage laparoscopic management of choledocholithiasis: An analysis after implementation of a mastery learning resident curriculum. ( 29191675 )
2018
39
Choledocholithiasis after Bariatric Surgery-More than a Stone's Throw to Reach? ( 29192385 )
2018
40
Physicians infrequently miss choledocholithiasis prior to cholecystectomy in the United States. ( 29208548 )
2018
41
Nonsurgical management of an extensive spontaneous spinal epidural hematoma causing quadriplegia and respiratory distress in a choledocholithiasis patient: A case report: Erratum. ( 29369212 )
2018
42
Management of endoscopic biliary stenting for choledocholithiasis: Evaluation of stent-exchange intervals. ( 29375741 )
2018
43
Pearl-White Gallstones Causing Choledocholithiasis. ( 29392151 )
2018
44
Successful endoscopic sphincterotomy for choledocholithiasis in a patient with severe hemophilia A and inhibitors. ( 29396835 )
2018
45
Choledocholithiasis in Roux-en-Y gastric bypass patients. ( 29453381 )
2018
46
Once upon a Time a Guideline Was Used for the Evaluation of Suspected Choledocholithiasis: A Fairy Tale or a Nightmare? ( 29457044 )
2018
47
Laparoscopic common bile duct exploration versus endoscopic retrograde cholangiopancreatography for choledocholithiasis found at time of laparoscopic cholecystectomy. ( 29477230 )
2018
48
Laparoscopic Common Bile Duct Exploration for Choledocholithiasis: Analysis of Practice Patterns of Intermountain HealthCare. ( 29518526 )
2018
49
The Safety and Efficacy of Laparoscopic Common Bile Duct Exploration Combined with Cholecystectomy for the Management of Cholecysto-choledocholithiasis: An Up-to-date Meta-analysis. ( 29533266 )
2018
50
Impact of Jaundice on Outcomes Following Emergency Laparoscopic Cholecystectomy in Patients with Choledocholithiasis. ( 29541824 )
2018

Variations for Choledocholithiasis

Expression for Choledocholithiasis

Search GEO for disease gene expression data for Choledocholithiasis.

Pathways for Choledocholithiasis

GO Terms for Choledocholithiasis

Sources for Choledocholithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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