MCID: CHL039
MIFTS: 39

Choledocholithiasis

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Choledocholithiasis

MalaCards integrated aliases for Choledocholithiasis:

Name: Choledocholithiasis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11755
MeSH 44 D042883
SNOMED-CT 68 49910001
UMLS 73 C0701818

Summaries for Choledocholithiasis

MalaCards based summary : Choledocholithiasis is related to cholelithiasis and cholangitis. An important gene associated with Choledocholithiasis is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Lysosome and FOXA2 and FOXA3 transcription factor networks. The drugs Meperidine and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone.

Wikipedia : 76 Common bile duct stone, also known as choledocholithiasis, is the presence of gallstones in the common... more...

Related Diseases for Choledocholithiasis

Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 cholelithiasis 30.8 ABCB4 ALB GPT UGT1A1
2 cholangitis 30.7 ABCB4 ALB F2 GPT
3 cholecystitis 30.6 ABCB4 ALB F2 GPT
4 cholecystolithiasis 30.5 ABCB4 STK10
5 extrahepatic cholestasis 30.2 ABCB4 GPT
6 hepatitis 30.0 F2 GPT SLC17A5
7 obstructive jaundice 30.0 ALB ALPP F2 GPT SLC17A5
8 cholestasis 29.9 ABCB4 ALPP F2 GPT
9 liver cirrhosis 29.9 ALB F2 GPT SLC17A5
10 ascending cholangitis 29.8 ALB F2
11 cholangitis, primary sclerosing 29.8 ABCB4 ALB GPT
12 biliary dyskinesia 29.8 SOBP STK10
13 portal hypertension 29.7 ALB F2 GPT
14 infantile liver failure syndrome 1 29.6 ALB F2 GPT SLC17A5
15 pancreatitis 10.4
16 acute cholangitis 10.4
17 degos 'en cocarde' erythrokeratoderma 10.3
18 paraquat poisoning 10.2 GPT SLC17A5
19 pyridoxine deficiency 10.2 GPT SLC17A5
20 fatty liver disease, nonalcoholic 1 10.2 GPT SLC17A5
21 scrub typhus 10.2 GPT SLC17A5
22 hepatoportal sclerosis 10.2 F2 GPT
23 cholangiocarcinoma 10.1
24 hepatitis d 10.1 F2 GPT
25 primary hepatic neuroendocrine carcinoma 10.1 ALPP GPT
26 antipyrine metabolism 10.1 ALB F2
27 non-a-e hepatitis 10.1 ALB F2
28 kernicterus 10.1 ALB UGT1A1
29 legionnaires' disease 10.1 ALB SLC17A5
30 epstein-barr virus hepatitis 10.1 ALB F2
31 papillon-lefevre syndrome 10.1 CTSC SLC17A5
32 fournier gangrene 10.1 ALB F2
33 abdominal tuberculosis 10.1 ALB F2
34 protein-energy malnutrition 10.1 ALB GPT
35 splenic disease 10.1 ALB F2
36 esophageal varix 10.1 ALB F2
37 acroosteolysis 10.1 ALB CTSC
38 hypersplenism 10.1 ALB F2
39 hepatorenal syndrome 10.1 ALB F2
40 nonalcoholic steatohepatitis 10.1 F2 GPT SLC17A5
41 meningoencephalitis 10.1 ALB SLC17A5
42 hepatic vascular disease 10.1 ALB F2
43 pulmonary artery disease 10.1 ALB F2
44 hellp syndrome 10.1 F2 GPT SLC17A5
45 dysfibrinogenemia 10.0 ALB F2
46 acute pancreatitis 10.0
47 hepatic coma 10.0 ALB F2 GPT
48 hemorrhagic fever 10.0 ALB F2 GPT
49 hepatitis e 10.0 ALB F2 GPT
50 hepatitis a 10.0 ALB F2 GPT

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to Choledocholithiasis

Symptoms & Phenotypes for Choledocholithiasis

Drugs & Therapeutics for Choledocholithiasis

Drugs for Choledocholithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
2
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
3
Etomidate Approved Phase 4 33125-97-2 667484 36339
4
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
5 Anti-Anxiety Agents Phase 4
6 Analgesics Phase 4
7 Anesthetics Phase 4,Not Applicable
8 GABA Modulators Phase 4
9 Central Nervous System Depressants Phase 4
10 Adjuvants, Anesthesia Phase 4
11 GABA Agents Phase 4
12 Analgesics, Opioid Phase 4
13 Anesthetics, Intravenous Phase 4
14 Neurotransmitter Agents Phase 4
15 Narcotics Phase 4
16 Tranquilizing Agents Phase 4
17 Hypnotics and Sedatives Phase 4
18 Peripheral Nervous System Agents Phase 4
19 Psychotropic Drugs Phase 4
20 Anesthetics, General Phase 4
21 Gastrointestinal Agents Phase 4
22 Cholagogues and Choleretics Phase 4
23 Pharmaceutical Solutions Phase 3
24
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
25
Cefotaxime Approved Not Applicable 63527-52-6 456256 5742673
26
Cefoxitin Approved Not Applicable 35607-66-0 441199
27
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
28
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
29 Tissue Plasminogen Activator Early Phase 1
30 Plasminogen Activator Inhibitor 1 Early Phase 1
31 Plasminogen Inactivators Early Phase 1
32 Plasminogen Early Phase 1
33 Glucagon-Like Peptide 1 Not Applicable
34 glucagon Not Applicable
35 Disinfectants Not Applicable
36 Anti-Infective Agents Not Applicable
37 Chlorhexidine gluconate Not Applicable
38 Anti-Infective Agents, Local Not Applicable
39 Antibiotics, Antitubercular ,Not Applicable
40 Anti-Bacterial Agents ,Not Applicable
41 Scopolamine hydrobromide Not Applicable 114-49-8
42 Butylscopolammonium Bromide Not Applicable
43 Retinol palmitate Not Applicable
44 retinol Not Applicable
45 Cephalosporins Not Applicable
46 Antitubercular Agents Not Applicable
47 pancreatin Not Applicable
48 Liver Extracts Not Applicable

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
2 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
3 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
4 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
5 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
6 Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary Obstruction Terminated NCT01424657 Phase 3
7 Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234 Not Applicable
8 The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis Unknown status NCT02647593
9 A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation Unknown status NCT00451581 Not Applicable
10 Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering Unknown status NCT00329888
11 Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope Unknown status NCT02276157
12 Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatography). Unknown status NCT01414400 Not Applicable
13 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147
14 Timing of Laparoscopic Cholecystectomy After Endoscopic Retrograde Cholangiography for Acute Biliary Pancreatitis Unknown status NCT01687959 Early Phase 1
15 Laser Versus Mechanical Lithotripsy of Bile Duct Stones Completed NCT01759979 Not Applicable
16 Prospective Evaluation of the Ability of Spyglass Cholangioscopy to Facilitate Radiation Free ERCP Completed NCT03074201 Not Applicable
17 Randomized Trial of ERCP Then Laparoscopic Cholecystectomy vs. Laparoscopic Cholecystectomy Plus Laparoscopic Common Bile Duct Exploration in Patients With Likely Choledocholithiasis Completed NCT00807729 Not Applicable
18 EUS Guided ERCP in Bile Duct Stone Removal Completed NCT02870686 Not Applicable
19 Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography Completed NCT02594475 Not Applicable
20 Effect of 8.5 F Plastic Stent Without Proximal Flap on Prevention of Post-ERCP Cholangitis Completed NCT02594891 Not Applicable
21 Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone Completed NCT00173368
22 Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy Completed NCT02037958 Not Applicable
23 Comparison Between Pre and Intraoperative ERCP in Treatment of Common Bile Duct Stones Completed NCT01046552 Not Applicable
24 Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD Completed NCT01673269 Not Applicable
25 Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones Completed NCT01683240 Not Applicable
26 Loop-tipped Guidewire in Selective Biliary Cannulation Completed NCT02028845 Not Applicable
27 ERCP in Super-aged Patients Considering Difficult Cannulation: Challenges and Adverse Events Completed NCT03771547
28 Early EUS in Acute Biliary Pancreatitis Completed NCT02430285 Not Applicable
29 Routine Bile Collection for Microbiological Analysis During Cholangiography Completed NCT01003782
30 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
31 Acute Biliary Pancreatitis - Optimal Time for Cholecystectomy Completed NCT03085407 Not Applicable
32 Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy Completed NCT01824186 Not Applicable
33 Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis Completed NCT02781987
34 Role of EUS in High Risk of Choledocholithiasis Recruiting NCT03250286 Not Applicable
35 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474 Not Applicable
36 "Endoscopy First" or "Laparoscopic Cholecystectomy First" for Patients With Intermediate Risk of Choledocholithiasis Recruiting NCT03658863 Not Applicable
37 The Comparisons of One-stage and Two-stage Stone Removal in Moderate Cholangitis Recruiting NCT03754491 Not Applicable
38 Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP Recruiting NCT02611453 Not Applicable
39 Microbiomes in Patients of Recurrent Common Bile Duct Stones Recruiting NCT03102281
40 Long-duration EPBD vs EST for Removal of Biliary Stones Recruiting NCT03683485 Not Applicable
41 Prospective Evaluation of Residual Bile Duct Stone by Peroral Cholangioscopy After Conventional ERCP Recruiting NCT03482375
42 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Recruiting NCT02958059 Not Applicable
43 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Recruiting NCT01438385
44 Los Angeles Prospective GI Biliary and EUS Series Recruiting NCT02196935
45 Non-Complex Biliary Stones DSC vs ERC Recruiting NCT03421340 Not Applicable
46 Chinese Registry Study on Treatment of Cholecysto-Choledocholithiasis Active, not recruiting NCT02554097
47 A Prospective Study of Treating Duodenal Papillary Sphincter in Different Ways During ERCP Enrolling by invitation NCT03416205 Not Applicable
48 Papillary Balloon Dilation Versus Laser Lithotripsy Not yet recruiting NCT03536247 Not Applicable
49 Early MRI in Acute GallstonE Disease Not yet recruiting NCT03709030 Not Applicable
50 Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients Terminated NCT00612846 Not Applicable

Search NIH Clinical Center for Choledocholithiasis

Cochrane evidence based reviews: choledocholithiasis

Genetic Tests for Choledocholithiasis

Anatomical Context for Choledocholithiasis

MalaCards organs/tissues related to Choledocholithiasis:

41
Liver, Testes, Bone, Lung, Colon, Heart, Bone Marrow

Publications for Choledocholithiasis

Articles related to Choledocholithiasis:

(show top 50) (show all 948)
# Title Authors Year
1
Pancreaticopleural fistula associated with choledocholithiasis: An infrequent complication of acute pancreatitis. ( 29530342 )
2018
2
Laparoscopic common bile duct exploration versus endoscopic retrograde cholangiopancreatography for choledocholithiasis found at time of laparoscopic cholecystectomy. ( 29477230 )
2018
3
Performance of the Choledocholithiasis Diagnostic Score in Patients with Acute Cholecystitis. ( 29457047 )
2018
4
Gallstone Pancreatitis and Choledocholithiasis: Using Imaging and Laboratory Trends to Predict the Likelihood of Persistent Stones at Cholangiography. ( 29626246 )
2018
5
Laparoscopic Common Bile Duct Exploration for Choledocholithiasis: Analysis of Practice Patterns of Intermountain HealthCare. ( 29518526 )
2018
6
Physicians infrequently miss choledocholithiasis prior to cholecystectomy in the United States. ( 29208548 )
2018
7
Successful endoscopic sphincterotomy for choledocholithiasis in a patient with severe hemophilia A and inhibitors. ( 29396835 )
2018
8
Outcomes Associated With Timing of ERCP in Acute Cholangitis Secondary to Choledocholithiasis. ( 29356786 )
2018
9
The Safety and Efficacy of Laparoscopic Common Bile Duct Exploration Combined with Cholecystectomy for the Management of Cholecysto-choledocholithiasis: An Up-to-date Meta-analysis. ( 29533266 )
2018
10
Risk assessment of choledocholithiasis prior to laparoscopic cholecystectomy and its management options. ( 29774157 )
2018
11
Impact of Jaundice on Outcomes Following Emergency Laparoscopic Cholecystectomy in Patients with Choledocholithiasis. ( 29541824 )
2018
12
Cholelithiasis and choledocholithiasis in children; risk factors for development. ( 29763444 )
2018
13
Electrohydraulic lithotripsy under double-balloon endoscope-assistedA direct cholangioscopy for treatmentA ofA choledocholithiasis in a patient with Roux-en-YA gastrectomy. ( 29916492 )
2018
14
Hemodialysis is a strong risk factor for post-endoscopic sphincterotomy bleeding in patients with choledocholithiasis. ( 29756014 )
2018
15
Role of Cholecystectomy After Endoscopic Sphincterotomy in the Management of Choledocholithiasis in High-risk Patients: A Systematic Review and Meta-Analysis. ( 29912758 )
2018
16
Nonsurgical management of an extensive spontaneous spinal epidural hematoma causing quadriplegia and respiratory distress in a choledocholithiasis patient: A case report: Erratum. ( 29369212 )
2018
17
Predictors for choledocholithiasis in patients undergoing endoscopic ultrasound. ( 29979088 )
2018
18
Pearl-White Gallstones Causing Choledocholithiasis. ( 29392151 )
2018
19
Single-stage laparoscopic management of choledocholithiasis: An analysis after implementation of a mastery learning resident curriculum. ( 29191675 )
2018
20
Various approaches of laparoscopic common bile duct exploration plus primary duct closure for choledocholithiasis: A systematic review and meta-analysis. ( 29627156 )
2018
21
Micro-Incision of the Cystic Duct Confluence in Laparoscopic Common Bile Duct Exploration for Elderly Patients with Choledocholithiasis. ( 29973752 )
2018
22
Management of endoscopic biliary stenting for choledocholithiasis: Evaluation of stent-exchange intervals. ( 29375741 )
2018
23
Safety and Efficacy of Endoscopic Retrograde Cholangiopancreatography for Choledocholithiasis in Long-Term Dialysis: A Propensity Score Analysis. ( 29767390 )
2018
24
Human fibrin sealant reduces post-operative bile leakage of primary closure after laparoscopic common bile duct exploration in patients with choledocholithiasis. ( 29974875 )
2018
25
Efficacy and Safety of Single-Session Endoscopic Stone Removal for Acute Cholangitis Associated with Choledocholithiasis. ( 30175087 )
2018
26
Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis. ( 30294608 )
2018
27
Preoperative Predictors of Choledocholithiasis in Patients Presenting with Acute Calculous Cholecystitis. ( 30465770 )
2018
28
Inpatient Choledocholithiasis Requiring ERCP and Cholecystectomy: Outcomes of a Combined Single Inpatient Procedure Versus Separate-Session Procedures. ( 28971298 )
2018
29
Comparative Study of Three Bile Duct Closure Methods Following Laparoscopic Common Bile Duct Exploration for Choledocholithiasis. ( 28976804 )
2018
30
Choledocholithiasis in Roux-en-Y gastric bypass patients. ( 29453381 )
2018
31
Once upon a Time a Guideline Was Used for the Evaluation of Suspected Choledocholithiasis: A Fairy Tale or a Nightmare? ( 29457044 )
2018
32
Catheter probe extraductal ultrasound (EDUS) exploration of the common bile duct is safe in elderly patients with suspicion of choledocholithiasis after distal gastrectomy. ( 29600432 )
2018
33
The added value of tomosynthesis in endoscopic retrograde cholangiography with radiography for the detection of choledocholithiasis. ( 29630390 )
2018
34
Association Between Juxtapapillary Duodenal Diverticula and Risk of Choledocholithiasis: a Systematic Review and Meta-analysis. ( 30022443 )
2018
35
In-Hospital Pediatric ERCP is Associated with Shorter Hospitalization for Children with Choledocholithiasis. ( 30044307 )
2018
36
Single-stage management of cholelithiasis and choledocholithiasis: Laparoscopic cholecystectomy and intra-operative endoscopic sphincterotomy (with video). ( 30072276 )
2018
37
Self-expandable metal stents for choledocholithiasis in Billroth II gastrectomy patients. ( 30126827 )
2018
38
The reasonable drainage option after laparoscopic common bile duct exploration for the treatment of choledocholithiasis. ( 30145281 )
2018
39
Percutaneous Transcholecystic Management of Choledocholithiasis: A Next Horizon for Interventional Radiologists? ( 30226458 )
2018
40
Modified laparoscopic Janeway gastrostomy: a novel adjunct for the management of choledocholithiasis in Roux-en-Y patients. ( 30275030 )
2018
41
Temporary CBD Stenting with a Nelaton Tube Is a More Practical and Safer Option Than T-Tube Drainage after Conventional CBD Exploration for Choledocholithiasis. ( 30302070 )
2018
42
Choledocholithiasis. ( 30304429 )
2018
43
Choledocholithiasis in elderly patients with gallbladder in situ - is ERCP sufficient? ( 30304966 )
2018
44
ASGE high-risk criteria for choledocholithiasis - Are they applicable in cholecystectomized patients? ( 30366810 )
2018
45
EUS-guided hepaticojejunostomy with transjejunal per-oral cholangioscopy and electrohydraulic lithotripsy in a patient with complicated choledocholithiasis after Roux-en-Y gastric bypass. ( 30402582 )
2018
46
Success of intraoperative imaging and management of suspected choledocholithiasis without pre-operative bile duct imaging - A case series. ( 30505436 )
2018
47
A two-stage versus single-stage procedure for the management of cholecysto-choledocholithiasis in elderly patients: a retrospectively cohort study. ( 30507246 )
2018
48
Long term outcome of EUS-based strategy for suspected choledocholithiasis but negative CT finding. ( 30516401 )
2018
49
Factors affecting the conversion to open surgery during laparoscopic cholecystectomy in patients with cholelithiasis undergoing ERCP due to choledocholithiasis. ( 28874623 )
2017
50
A predictive nomogram to identify factors influencing the success of a concomitant laparoscopic cholecystectomy with common bile duct exploration for choledocholithiasis. ( 29100711 )
2017

Variations for Choledocholithiasis

Expression for Choledocholithiasis

Search GEO for disease gene expression data for Choledocholithiasis.

Pathways for Choledocholithiasis

Pathways related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.89 CTSC GUSB SLC17A5
2 10.6 ALB F2

GO Terms for Choledocholithiasis

Cellular components related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.17 ABCB4 ALB CTSC F2 GPT GUSB
2 endoplasmic reticulum lumen GO:0005788 9.13 ALB CTSC F2

Biological processes related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.62 F2 UGT1A1

Molecular functions related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT

Sources for Choledocholithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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