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MCID: CHL039
MIFTS: 37

Choledocholithiasis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Choledocholithiasis

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MalaCards integrated aliases for Choledocholithiasis:

Name: Choledocholithiasis 12 55 44 15 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11755
MeSH 44 D042883
UMLS 73 C0701818
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Summaries for Choledocholithiasis

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MalaCards based summary : Choledocholithiasis is related to cholecystolithiasis and extrahepatic cholestasis. An important gene associated with Choledocholithiasis is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Lysosome and FOXA2 and FOXA3 transcription factor networks. The drugs Etomidate and Meperidine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and thyroid.

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Related Diseases for Choledocholithiasis

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Diseases related to Choledocholithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 cholecystolithiasis 30.6 ABCB4 STK10
2 extrahepatic cholestasis 30.6 ABCB4 GPT
3 cholelithiasis 30.3 ABCB4 ALB GPT UGT1A1
4 hepatitis 30.1 F2 GPT SLC17A5
5 cholangitis 30.1 ABCB4 ALB F2 GPT
6 ascending cholangitis 29.9 ALB F2
7 cholecystitis 29.9 ABCB4 ALB F2 GPT
8 intrahepatic cholestasis 29.6 ABCB4 ALB SLC17A5
9 portal hypertension 29.6 ALB F2 GPT
10 liver cirrhosis 29.5 ALB F2 GPT SLC17A5
11 cholestasis 29.4 ABCB4 ALPP F2 GPT
12 biliary dyskinesia 29.2 SOBP STK10
13 obstructive jaundice 28.2 ALB ALPP F2 GPT SLC17A5
14 paraquat poisoning 10.7 GPT SLC17A5
15 pyridoxine deficiency 10.7 GPT SLC17A5
16 hepatoportal sclerosis 10.6 F2 GPT
17 scrub typhus 10.5 GPT SLC17A5
18 hepatitis d 10.5 F2 GPT
19 primary hepatic neuroendocrine carcinoma 10.5 ALPP GPT
20 antipyrine metabolism 10.4 ALB F2
21 non-a-e hepatitis 10.4 ALB F2
22 papillon-lefevre syndrome 10.4 CTSC SLC17A5
23 legionnaires' disease 10.4 ALB SLC17A5
24 fournier gangrene 10.4 ALB F2
25 kernicterus 10.4 ALB UGT1A1
26 abdominal tuberculosis 10.4 ALB F2
27 splenic disease 10.3 ALB F2
28 autoimmune disease of urogenital tract 10.3 ABCB4 ALB
29 esophageal varix 10.3 ALB F2
30 nonalcoholic steatohepatitis 10.3 F2 GPT SLC17A5
31 hypersplenism 10.3 ALB F2
32 hellp syndrome 10.2 F2 GPT SLC17A5
33 protein-energy malnutrition 10.2 ALB GPT
34 hepatorenal syndrome 10.2 ALB F2
35 acroosteolysis 10.2 ALB CTSC
36 pancreatitis 10.2
37 hepatic vascular disease 10.2 ALB F2
38 dysfibrinogenemia 10.2 ALB F2
39 splenic infarction 10.2 F2 STK10
40 acute cholangitis 10.1
41 endodermal sinus tumor 10.1 ALB ALPP
42 vein disease 10.1 ALB F2
43 hepatic coma 10.1 ALB F2 GPT
44 hemorrhagic fever 10.1 ALB F2 GPT
45 hepatitis e 10.1 ALB F2 GPT
46 hepatitis a 10.1 ALB F2 GPT
47 compartment syndrome 10.1 ALB F2 SLC17A5
48 wilson disease 10.1 ALB F2 GPT
49 alcoholic liver cirrhosis 10.1 ALB F2 SLC17A5
50 intermittent claudication 10.0 ALB F2

Graphical network of the top 20 diseases related to Choledocholithiasis:



Diseases related to Choledocholithiasis
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Symptoms & Phenotypes for Choledocholithiasis

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Drugs & Therapeutics for Choledocholithiasis

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Drugs for Choledocholithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 4 33125-97-2 36339 667484
2
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
3
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
4
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
5 Adjuvants, Anesthesia Phase 4
6 Analgesics Phase 4
7 Analgesics, Opioid Phase 4
8 Anesthetics Phase 4,Not Applicable
9 Anesthetics, General Phase 4
10 Anesthetics, Intravenous Phase 4
11 Anti-Anxiety Agents Phase 4
12 Central Nervous System Depressants Phase 4
13 GABA Agents Phase 4
14 GABA Modulators Phase 4
15 Hypnotics and Sedatives Phase 4
16 Narcotics Phase 4
17 Neurotransmitter Agents Phase 4
18 Peripheral Nervous System Agents Phase 4
19 Psychotropic Drugs Phase 4
20 Tranquilizing Agents Phase 4
21 Cholagogues and Choleretics Phase 4
22 Gastrointestinal Agents Phase 4
23 Pharmaceutical Solutions Phase 3
24
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 9552079 2713
25
Cefotaxime Approved Not Applicable 63527-52-6 456256 5742673
26
Cefoxitin Approved Not Applicable 35607-66-0 441199
27 Plasminogen Early Phase 1
28 Plasminogen Activator Inhibitor 1 Early Phase 1
29 Plasminogen Inactivators Early Phase 1
30 Tissue Plasminogen Activator Early Phase 1
31 glucagon Not Applicable
32 Glucagon-Like Peptide 1 Not Applicable
33 Anti-Infective Agents Not Applicable
34 Anti-Infective Agents, Local Not Applicable
35 Chlorhexidine gluconate Not Applicable
36 Disinfectants Not Applicable
37 Anti-Bacterial Agents ,Not Applicable
38 Antibiotics, Antitubercular ,Not Applicable
39 Butylscopolammonium Bromide Not Applicable
40 Scopolamine hydrobromide Not Applicable 114-49-8
41 Antitubercular Agents Not Applicable
42 Cephalosporins Not Applicable

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
2 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
3 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
4 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
5 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
6 Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary Obstruction Terminated NCT01424657 Phase 3
7 Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234 Not Applicable
8 The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis Unknown status NCT02647593
9 A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation Unknown status NCT00451581 Not Applicable
10 Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering Unknown status NCT00329888
11 Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope Unknown status NCT02276157
12 Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatogr Unknown status NCT01414400 Not Applicable
13 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147
14 Timing of Laparoscopic Cholecystectomy After Endoscopic Retrograde Cholangiography for Acute Biliary Pancreatitis Unknown status NCT01687959 Early Phase 1
15 Laser Versus Mechanical Lithotripsy of Bile Duct Stones Completed NCT01759979 Not Applicable
16 Randomized Trial of ERCP Then Laparoscopic Cholecystectomy vs. Laparoscopic Cholecystectomy Plus Laparoscopic Common Bile Duct Exploration in Patients With Likely Choledocholithiasis Completed NCT00807729 Not Applicable
17 EUS Guided ERCP in Bile Duct Stone Removal Completed NCT02870686 Not Applicable
18 Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography Completed NCT02594475 Not Applicable
19 Effect of 8.5 F Plastic Stent Without Proximal Flap on Prevention of Post-ERCP Cholangitis Completed NCT02594891 Not Applicable
20 Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone Completed NCT00173368
21 Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy Completed NCT02037958 Not Applicable
22 Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD Completed NCT01673269 Not Applicable
23 Comparison Between Pre and Intraoperative ERCP in Treatment of Common Bile Duct Stones Completed NCT01046552 Not Applicable
24 Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones Completed NCT01683240 Not Applicable
25 Loop-tipped Guidewire in Selective Biliary Cannulation Completed NCT02028845 Not Applicable
26 Early EUS in Acute Biliary Pancreatitis Completed NCT02430285 Not Applicable
27 Routine Bile Collection for Microbiological Analysis During Cholangiography Completed NCT01003782
28 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
29 Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy Completed NCT01824186 Not Applicable
30 Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis Completed NCT02781987
31 Role of EUS in High Risk of Choledocholithiasis Recruiting NCT03250286 Not Applicable
32 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474 Not Applicable
33 Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP Recruiting NCT02611453 Not Applicable
34 Prospective Evaluation of the Ability of Spyglass Cholangioscopy to Facilitate Radiation Free ERCP Recruiting NCT03074201 Not Applicable
35 Microbiomes in Patients of Recurrent Common Bile Duct Stones Recruiting NCT03102281
36 Prospective Evaluation of Residual Bile Duct Stone by Peroral Cholangioscopy After Conventional ERCP Recruiting NCT03482375
37 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Recruiting NCT02958059 Not Applicable
38 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Recruiting NCT01438385
39 Los Angeles Prospective GI Biliary and EUS Series Recruiting NCT02196935
40 Acute Biliary Pancreatitis - Optimal Time for Cholecystectomy Active, not recruiting NCT03085407 Not Applicable
41 A Prospective Study of Treating Duodenal Papillary Sphincter in Different Ways During ERCP Enrolling by invitation NCT03416205 Not Applicable
42 Optimization and Cost-effective Analysis of Secondary Biliary Stones' Managements Enrolling by invitation NCT02554097
43 Papillary Balloon Dilation Versus Laser Lithotripsy Not yet recruiting NCT03536247 Not Applicable
44 Non-Complex Biliary Stones DSC vs ERC Not yet recruiting NCT03421340 Not Applicable
45 Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients Terminated NCT00612846 Not Applicable
46 Management of Common Bile Duct (CBD) Stones at Laparoscopic Cholecystectomy Terminated NCT00124033 Not Applicable
47 Prospective Evaluation of the Covered Self-expandable Metal Stents (CSEMS) for Incomplete Biliary Stone Clearance Withdrawn NCT01475864

Search NIH Clinical Center for Choledocholithiasis

Cochrane evidence based reviews: choledocholithiasis

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Genetic Tests for Choledocholithiasis

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Anatomical Context for Choledocholithiasis

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MalaCards organs/tissues related to Choledocholithiasis:

41
Liver, Testes, Thyroid, Heart
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Publications for Choledocholithiasis

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Articles related to Choledocholithiasis:

(show top 50) (show all 666)
# Title Authors Year
1
Pancreaticopleural fistula associated with choledocholithiasis: An infrequent complication of acute pancreatitis. ( 29530342 )
2018
2
Laparoscopic common bile duct exploration versus endoscopic retrograde cholangiopancreatography for choledocholithiasis found at time of laparoscopic cholecystectomy. ( 29477230 )
2018
3
Performance of the Choledocholithiasis Diagnostic Score in Patients with Acute Cholecystitis. ( 29457047 )
2018
4
Gallstone Pancreatitis and Choledocholithiasis: Using Imaging and Laboratory Trends to Predict the Likelihood of Persistent Stones at Cholangiography. ( 29626246 )
2018
5
Laparoscopic Common Bile Duct Exploration for Choledocholithiasis: Analysis of Practice Patterns of Intermountain HealthCare. ( 29518526 )
2018
6
Physicians infrequently miss choledocholithiasis prior to cholecystectomy in the United States. ( 29208548 )
2018
7
Successful endoscopic sphincterotomy for choledocholithiasis in a patient with severe hemophilia A and inhibitors. ( 29396835 )
2018
8
Outcomes Associated With Timing of ERCP in Acute Cholangitis Secondary to Choledocholithiasis. ( 29356786 )
2018
9
The Safety and Efficacy of Laparoscopic Common Bile Duct Exploration Combined with Cholecystectomy for the Management of Cholecysto-choledocholithiasis: An Up-to-date Meta-analysis. ( 29533266 )
2018
10
Risk assessment of choledocholithiasis prior to laparoscopic cholecystectomy and its management options. ( 29774157 )
2018
11
Impact of Jaundice on Outcomes Following Emergency Laparoscopic Cholecystectomy in Patients with Choledocholithiasis. ( 29541824 )
2018
12
Cholelithiasis and choledocholithiasis in children; risk factors for development. ( 29763444 )
2018
13
Electrohydraulic lithotripsy under double-balloon endoscope-assistedA direct cholangioscopy for treatmentA ofA choledocholithiasis in a patient with Roux-en-YA gastrectomy. ( 29916492 )
2018
14
Hemodialysis is a strong risk factor for post-endoscopic sphincterotomy bleeding in patients with choledocholithiasis. ( 29756014 )
2018
15
Role of Cholecystectomy After Endoscopic Sphincterotomy in the Management of Choledocholithiasis in High-risk Patients: A Systematic Review and Meta-Analysis. ( 29912758 )
2018
16
Nonsurgical management of an extensive spontaneous spinal epidural hematoma causing quadriplegia and respiratory distress in a choledocholithiasis patient: A case report: Erratum. ( 29369212 )
2018
17
Predictors for choledocholithiasis in patients undergoing endoscopic ultrasound. ( 29979088 )
2018
18
Pearl-White Gallstones Causing Choledocholithiasis. ( 29392151 )
2018
19
Single-stage laparoscopic management of choledocholithiasis: An analysis after implementation of a mastery learning resident curriculum. ( 29191675 )
2018
20
Various approaches of laparoscopic common bile duct exploration plus primary duct closure for choledocholithiasis: A systematic review and meta-analysis. ( 29627156 )
2018
21
Micro-Incision of the Cystic Duct Confluence in Laparoscopic Common Bile Duct Exploration for Elderly Patients with Choledocholithiasis. ( 29973752 )
2018
22
Management of endoscopic biliary stenting for choledocholithiasis: Evaluation of stent-exchange intervals. ( 29375741 )
2018
23
Safety and Efficacy of Endoscopic Retrograde Cholangiopancreatography for Choledocholithiasis in Long-Term Dialysis: A Propensity Score Analysis. ( 29767390 )
2018
24
Human fibrin sealant reduces post-operative bile leakage of primary closure after laparoscopic common bile duct exploration in patients with choledocholithiasis. ( 29974875 )
2018
25
The added value of tomosynthesis in endoscopic retrograde cholangiography with radiography for the detection of choledocholithiasis. ( 29630390 )
2018
26
Catheter probe extraductal ultrasound (EDUS) exploration of the common bile duct is safe in elderly patients with suspicion of choledocholithiasis after distal gastrectomy. ( 29600432 )
2018
27
Factors affecting the conversion to open surgery during laparoscopic cholecystectomy in patients with cholelithiasis undergoing ERCP due to choledocholithiasis. ( 28874623 )
2017
28
A predictive nomogram to identify factors influencing the success of a concomitant laparoscopic cholecystectomy with common bile duct exploration for choledocholithiasis. ( 29100711 )
2017
29
Choledocholithiasis: Should EUS replace MRCP in patients at intermediate risk? ( 29146091 )
2017
30
Cholangiohepatitis With Extensive Intrahepatic Choledocholithiasis. ( 28754269 )
2017
31
Can Endoscopic Ultrasonography Prevent Unnecessary Endoscopic Retrograde Cholangiopancreatography in Patients with High and Intermediate Likelihood of Choledocholithiasis? ( 29207858 )
2017
32
Choledocholithiasis ( 28722990 )
2017
33
Efficiency and Safety of One-Step Procedure Combined Laparoscopic Cholecystectomy and Eretrograde Cholangiopancreatography for Treatment of Cholecysto-Choledocholithiasis: A Randomized Controlled Trial. ( 29183529 )
2017
34
Three modalities on management of choledocholithiasis: A prospective cohort study. ( 28668286 )
2017
35
Practice Patterns for Cholecystectomy After Endoscopic Retrograde Cholangiopancreatography for Patients With Choledocholithiasis. ( 28583822 )
2017
36
Pancreatogenic choledocholithiasis in common bile duct stump after Roux-en-Y hepaticojejunostomy: A case report. ( 29145338 )
2017
37
A prospective evaluation of radiation-free direct solitary cholangioscopy for the management of choledocholithiasis. ( 28797911 )
2017
38
Transenteric ERCP for Treatment of Choledocholithiasis After Duodenal Switch. ( 28520653 )
2017
39
The Relationship between Age, Common Bile Duct Diameter and Diagnostic Probability in Suspected Choledocholithiasis. ( 28668951 )
2017
40
Nonsurgical management of an extensive spontaneous spinal epidural hematoma causing quadriplegia and respiratory distress in a choledocholithiasis patient: A case report. ( 29390530 )
2017
41
Pneumomediastinum and pneumoperitoneum following partial sphincterotomy for choledocholithiasis. ( 29110134 )
2017
42
Management of choledocholithiasis after previous gastrectomy. ( 28853602 )
2017
43
Laparoendoscopic rendez-vous: a safe alternative to the treatment of choledocholithiasis. ( 28731998 )
2017
44
Recombinant Factor VIIa Use for Endoscopic Retrograde Cholangiopancreatography With Sphincterotomy in a Patient With Choledocholithiasis and Unusual Coagulopathy. ( 28496540 )
2017
45
Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia. ( 29132521 )
2017
46
Temporal trends in utilization and outcomes of endoscopic retrograde cholangiopancreatography in acute cholangitis due to choledocholithiasis from 1998 to 2012. ( 28917018 )
2017
47
Percutaneous transhepatic cholangioscopy with intraductal electrohydraulic lithotripsy for management of choledocholithiasis in an inaccessible papilla. ( 29905272 )
2017
48
Percutaneous transcystic balloon dilation for common bile duct stone removal in high-surgical-risk patients with acute cholecystitis and co-existing choledocholithiasis. ( 29146469 )
2017
49
Cost analysis of robot-assisted choledochotomy and common bile duct exploration as an option for complex choledocholithiasis. ( 28812193 )
2017
50
Laparoscopic common bile duct exploration versus endoscopic retrograde cholangiopancreatography for choledocholithiasis found at time of laparoscopic cholecystectomy: Analysis of a large integrated health care system database. ( 28939251 )
2017
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Variations for Choledocholithiasis

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Expression for Choledocholithiasis

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Search GEO for disease gene expression data for Choledocholithiasis.
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Pathways for Choledocholithiasis

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Pathways related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Lysosome 37
10.89 CTSC GUSB SLC17A5
2
FOXA2 and FOXA3 transcription factor networks 1
10.6 ALB F2
Sources

GO Terms for Choledocholithiasis

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Cellular components related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.17 ABCB4 ALB CTSC F2 GPT GUSB
2 endoplasmic reticulum lumen GO:0005788 9.13 ALB CTSC F2

Biological processes related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.16 F2 UGT1A1
2 cellular response to estradiol stimulus GO:0071392 8.96 ABCB4 UGT1A1
3 response to organic substance GO:0010033 8.8 ABCB4 CTSC UGT1A1

Molecular functions related to Choledocholithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT
Sources

Sources for Choledocholithiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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