MCID: CHL004
MIFTS: 50

Cholelithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholelithiasis

MalaCards integrated aliases for Cholelithiasis:

Name: Cholelithiasis 12 76 29 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10211
ICD9CM 35 574.5
SNOMED-CT 68 197397004 266475002
ICD10 33 K80

Summaries for Cholelithiasis

MalaCards based summary : Cholelithiasis is related to cholecystolithiasis and gallbladder disease 4. An important gene associated with Cholelithiasis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Benzocaine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and pancreas, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 76 A gallstone is a stone formed within the gallbladder out of bile components. The term cholelithiasis may... more...

Related Diseases for Cholelithiasis

Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 cholecystolithiasis 32.2 ABCB4 CCK
2 gallbladder disease 4 31.8 ABCG5 ABCG8
3 choledocholithiasis 30.5 ABCB4 ALB GPT UGT1A1
4 cholecystitis 30.4 ABCB4 ALB CCK GPT
5 sickle cell anemia 30.2 HBB UGT1A1 UGT1A6
6 postcholecystectomy syndrome 30.2 CCK SST
7 cholangitis 30.1 ABCB4 ALB GPT
8 intrahepatic cholestasis 30.1 ABCB4 ALB NR1H4
9 liver cirrhosis 30.1 ALB GPT SST
10 ascending cholangitis 30.1 ALB CCK
11 duodenogastric reflux 30.0 CCK SST
12 liver disease 29.9 ABCB4 ALB GPT NR1H4
13 acute pancreatitis 29.6 CCK CCKAR SST
14 portal hypertension 29.5 ALB GPT SST
15 aortic atherosclerosis 29.4 ABCG5 ABCG8 APOE
16 cholestasis 29.2 ABCB4 CYP7A1 GPT NR1H4
17 biliary tract disease 28.1 ABCB4 ALB CCK CYP7A1 NR1H4
18 gallbladder disease 26.4 ABCB4 ABCG5 ABCG8 APOE CCK CCKAR
19 gallbladder disease 1 12.1
20 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 11.1
21 spherocytosis, type 1 10.8
22 overhydrated hereditary stomatocytosis 10.8
23 bisphosphoglycerate mutase deficiency 10.8
24 duodenal atresia 10.8
25 beta-thalassemia, dominant inclusion body type 10.8
26 spherocytosis, type 2 10.8
27 dehydrated hereditary stomatocytosis 2 10.8
28 clonorchiasis 10.8
29 cholestasis, progressive familial intrahepatic, 1 10.8 ABCB4 NR1H4
30 familial lcat deficiency 10.6 ALB APOE
31 glucosephosphate dehydrogenase deficiency 10.6 HBB UGT1A1
32 yellow nail syndrome 10.6 ALB SST
33 paralytic ileus 10.5 ALB CCK
34 splenic disease 10.5 ALB HBB
35 chylothorax, congenital 10.5 ALB SST
36 bilirubin, serum level of, quantitative trait locus 1 10.5 UGT1A1 UGT1A6
37 kwashiorkor 10.5 ALB GPT
38 hepatic tuberculosis 10.5 ALB GPT
39 pancreatic cholera 10.4 CCK SST
40 hepatic coma 10.4 ALB GPT
41 esophageal varix 10.4 ALB SST
42 descending colon cancer 10.4 UGT1A1 UGT1A6
43 primary biliary cirrhosis 10.4 ABCB4 ALB NR1H4
44 duodenal gastrinoma 10.4 CCK SST
45 binswanger's disease 10.3 APOE SST
46 pigmentation disease 10.3 UGT1A1 UGT1A6
47 opioid abuse 10.3 CCK CCKAR
48 kernicterus 10.2 ALB UGT1A1 UGT1A6
49 biliary atresia 10.2 ALB GPT NR1H4
50 fascioliasis 10.2 ALB GPT

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to Cholelithiasis

Symptoms & Phenotypes for Cholelithiasis

MGI Mouse Phenotypes related to Cholelithiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 ABCB4 ABCG5 ABCG8 ALB APOE CCKAR
2 endocrine/exocrine gland MP:0005379 9.7 NR1H4 SCARB1 ABCB4 ALB APOE CCK
3 homeostasis/metabolism MP:0005376 9.7 ABCB4 ABCG5 ABCG8 ALB APOE CCK
4 liver/biliary system MP:0005370 9.28 CCKAR CYP7A1 NR1H4 SCARB1 ABCB4 ABCG5

Drugs & Therapeutics for Cholelithiasis

Drugs for Cholelithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 236)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
2
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
8
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
9
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
10
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
11
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
12
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
13
Acetaminophen Approved Phase 4 103-90-2 1983
14
Clonidine Approved Phase 4 4205-90-7 2803
15 Nefopam Approved, Investigational Phase 4 13669-70-0
16
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
17
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 128-13-2 31401
18
Ondansetron Approved Phase 4 99614-02-5 4595
19
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
20
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
21
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
22
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
23
Ephedrine Approved Phase 4 299-42-3 9294
24
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
25
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
26
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
27
Morphine Approved, Investigational Phase 4 57-27-2 5288826
28
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
29
Pseudoephedrine Approved Phase 4 90-82-4 7028
30
Etomidate Approved Phase 4 33125-97-2 36339 667484
31
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
32
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
33
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
34
Tauroursodeoxycholic acid Approved, Investigational Phase 4 14605-22-2 12443252
35
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
36
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
37
Sulbactam Approved Phase 4 68373-14-8
38 Sultamicillin Approved, Investigational Phase 4 76497-13-7
39 tannic acid Approved, Nutraceutical Phase 4
40 Analgesics Phase 4,Not Applicable
41 Analgesics, Opioid Phase 4,Not Applicable
42 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Anesthetics, General Phase 4,Not Applicable
44 Anesthetics, Intravenous Phase 4
45 Central Nervous System Depressants Phase 4,Phase 1,Not Applicable
46 Hypnotics and Sedatives Phase 4,Phase 1
47 Narcotics Phase 4,Not Applicable
48 Peripheral Nervous System Agents Phase 4,Phase 1,Not Applicable
49 Adjuvants, Anesthesia Phase 4
50 Anesthetics, Dissociative Phase 4

Interventional clinical trials:

(show top 50) (show all 281)
# Name Status NCT ID Phase Drugs
1 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
2 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
3 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
4 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
5 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
6 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
7 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
8 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
9 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
10 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
11 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
12 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
13 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
14 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
15 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
16 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
17 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
18 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
19 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
20 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
21 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
22 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
23 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
24 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
25 Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain Completed NCT03265223 Phase 4 0.2% ropivacaine
26 Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy Completed NCT01717222 Phase 4 Intraperitoneal Lignocaine;Intravenous Lignocaine
27 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
28 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
29 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
30 The Discovery of the Double Sphincter in Gallbladder Recruiting NCT01998451 Phase 4 Tauroursodeoxycholic acid
31 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Recruiting NCT03168555 Phase 4 chenodeoxycholic acid
32 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
33 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
34 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
35 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
36 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
37 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
38 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
39 Renalof in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
40 Compare Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones Completed NCT00164853 Phase 3
41 Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery Completed NCT00835250 Phase 3
42 Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Completed NCT00370344 Phase 2, Phase 3
43 Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery for Cholecystectomy Completed NCT01558414 Phase 3
44 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
45 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy Completed NCT00447304 Phase 3 moxifloxacin
46 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
47 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
48 A Clinical Trial to Assess the Efficacy and Safety of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-383) Completed NCT02550288 Phase 3 Ezetimibe 10 mg;Atorvastatin 10 mg;Placebo for Ezetimibe 10 mg tablet;Placebo for Atorvastatin 10 mg capsule
49 A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-384) Completed NCT02460159 Phase 3 EZ 10 mg/Atorva 20 mg FDC;EZ 10 mg/Atorva 10 mg FDC
50 A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832) Completed NCT02741245 Phase 3 Ezetimibe 10 mg;Rosuvastatin 2.5 mg;Placebo for Ezetimibe;Placebo for Rosuvastatin

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Cholelithiasis

Genetic tests related to Cholelithiasis:

# Genetic test Affiliating Genes
1 Cholelithiasis 29

Anatomical Context for Cholelithiasis

MalaCards organs/tissues related to Cholelithiasis:

41
Liver, Skin, Pancreas, Kidney, Bone, Heart, Colon

Publications for Cholelithiasis

Articles related to Cholelithiasis:

(show top 50) (show all 686)
# Title Authors Year
1
Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta-analysis. ( 29266548 )
2018
2
Ultrasound characteristics and outcome of prenatally diagnosed fetal cholelithiasis. ( 29301452 )
2018
3
Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study. ( 29538289 )
2018
4
Total bilirubin trend as a predictor of common bile duct stones in acute cholecystitis and symptomatic cholelithiasis. ( 29929909 )
2018
5
Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden. ( 29970034 )
2018
6
Role of Cholelithiasis in Development of Portal Vein Aneurysm. ( 29454428 )
2018
7
Cholelithiasis and choledocholithiasis in children; risk factors for development. ( 29763444 )
2018
8
Effects of gender and age on prevalence of cholelithiasis in patients with chronic HCV infection: A community-based cross-sectional study in an HCV-hyperendemic area. ( 29851796 )
2018
9
Prevalence of Non-insulin-dependent Diabetes Mellitus Among Patients with Cholelithiasis: A Single-centered, Cross-sectional Study. ( 29888148 )
2018
10
Symptomatic Cholelithiasis of a Remnant Gallbladder after Open Cholecystectomy. ( 29941371 )
2018
11
Interventional Radiology-Operated Cholecystoscopy for the Management of Symptomatic Cholelithiasis: Approach, Technical Success, Safety, and Clinical Outcomes. ( 29547060 )
2018
12
Metagenomics of Microbial Communities in Gallbladder Bile from Patients with Gallbladder Cancer or Cholelithiasis ( 29693356 )
2018
13
A New Intelligent Medical Decision Support System Based on Enhanced Hierarchical Clustering and Random Decision Forest for the Classification of Alcoholic Liver Damage, Primary Hepatoma, Liver Cirrhosis, and Cholelithiasis. ( 29599940 )
2018
14
Cholelithiasis ( 29262107 )
2017
15
Factors affecting the conversion to open surgery during laparoscopic cholecystectomy in patients with cholelithiasis undergoing ERCP due to choledocholithiasis. ( 28874623 )
2017
16
Miniinvasive surgical interventions in management of cholelithiasis A retrospective study. ( 28604381 )
2017
17
Cholecystolithotomy Combined Armillarisin A versus Cholecystectomy in Cirrhotic Portal Hypertension Patients with Symptomatic Cholelithiasis. ( 28463673 )
2017
18
Is Concomitant Cholecystectomy Necessary for Asymptomatic Cholelithiasis During Laparoscopic Sleeve Gastrectomy? ( 28803397 )
2017
19
Is the oral contraceptive or hormone replacement therapy a risk factor for cholelithiasis: A systematic review and meta-analysis. ( 28383429 )
2017
20
Don't put off until tomorrow what you can do today: Early cholecystectomy is cost-effective in symptomatic cholelithiasis requiring hospitalization. ( 29133302 )
2017
21
Fetal Cholelithiasis: Antenatal Diagnosis and Neonatal Follow-Up in a Case of Twin Pregnancy - A Case Report and Review of the Literature. ( 28210714 )
2017
22
Pre- and Post-operative Comparative Analysis of Serum Lipid Profile in Patients with Cholelithiasis. ( 28904919 )
2017
23
Associations between serum leptin levels, hyperlipidemia, and cholelithiasis in dogs. ( 29088261 )
2017
24
Effectiveness of Ultrasound Shear for Clipless Laparoscopic Cholecystectomy Versus Conventional Unipolar Electrocautery in Patients with Cholelithiasis. ( 29056121 )
2017
25
Physical Chemistry of Bile: Detailed Pathogenesis of Cholelithiasis. ( 28350710 )
2017
26
Intrahepatic cholelithiasis in dogs and cats: A case series. ( 28878422 )
2017
27
Single Stage Management of Concomitant Cholelithiasis and Choledocholithiasis. ( 28598447 )
2017
28
Cholecystoduodenal fistula, an infrequent complication of cholelithiasis: Our experience in its surgical management. ( 28389051 )
2017
29
Cholelithiasis. ( 28745992 )
2017
30
Do Alpha Thalassemia, Fetal Hemoglobin, and the UGT1A1 Polymorphism have an Influence on Serum Bilirubin Levels and Cholelithiasis in Patients with Sickle Cell Disease? ( 28567595 )
2017
31
Laparoscopic cholecystectomy for cholelithiasis in children with sickle cell disease. ( 28555355 )
2017
32
Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials. ( 28244632 )
2017
33
Cholelithiasis and its complications in sickle cell disease in a university hospital. ( 28270342 )
2017
34
Cholelithiasis - always infected? ( 28703118 )
2017
35
Etiology and Outcome of Cholelithiasis in Turkish Children. ( 29242416 )
2017
36
Cholelithiasis in a Patient With History of Cholecystectomy. ( 28870658 )
2017
37
Sex differences in prevalence and risk factors of asymptomatic cholelithiasis in Korean health screening examinee: A retrospective analysis of a multicenter study. ( 28353587 )
2017
38
Cholelithiasis in adult bearded dragons: retrospective study of nine adult bearded dragons (Pogona vitticeps) with cholelithiasis between 2013 and 2015 in southern Germany. ( 28627055 )
2017
39
Case report of cholelithiasis in a patient with type 1 Gaucher disease. ( 27915213 )
2016
40
Evidence-based clinical practice guidelines for cholelithiasis 2016. ( 27942871 )
2016
41
Interval increase in the prevalence of symptomatic cholelithiasis-associated non-alcoholic fatty liver disease over a ten-year period in an Asian population. ( 27995261 )
2016
42
Risk Factors for Cholelithiasis. ( 27467059 )
2016
43
Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures: Retrospective Cohort Analysis of a US Population. ( 26706861 )
2016
44
The Progression of Cholelithiasis to Gallstone Ileus: Do Large Gallstones Warrant Surgery? ( 26857589 )
2016
45
Severe acute hemorrhagic pancreatitis secondary to cholelithiasis as a rare cause of sudden unexpected death in medico-legal case: A case report. ( 27559973 )
2016
46
Effect of emodin on mobility signal transduction system of gallbladder smooth muscle in Guinea pig with cholelithiasis. ( 27794381 )
2016
47
Evaluation of incidence of cholelithiasis after bariatric surgery in subjects treated or not treated with ursodeoxycholic acid. ( 28089591 )
2016
48
Obesity Not Necessary, Risk of Symptomatic Cholelithiasis Increases as a Function of BMI. ( 27891394 )
2016
49
Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder. ( 27376020 )
2016
50
Cholelithiasis and complicated chronic pancreatitis mimicking malignancy. ( 26882896 )
2016

Variations for Cholelithiasis

Expression for Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for Cholelithiasis

Pathways related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 ABCB4 ABCG5 ABCG8 ALB APOE CYP7A1
2
Show member pathways
12.34 ABCG5 ABCG8 ALB APOE SCARB1
3 12.3 APOE HBB UGT1A1 UGT1A6
4
Show member pathways
12.11 ALB APOE HBB SCARB1
5
Show member pathways
11.96 ALB CYP7A1 NR1H4
6
Show member pathways
11.69 ALB APOE HBB SCARB1
7
Show member pathways
11.63 ABCG5 ABCG8 APOE CYP7A1 SCARB1
8
Show member pathways
11.48 CYP7A1 UGT1A1 UGT1A6
9
Show member pathways
11.28 ABCG5 ABCG8 SCARB1
10 11.25 ABCG5 ABCG8 SCARB1
11 10.95 ABCB4 ABCG5 ABCG8 CYP7A1 NR1H4 SCARB1
12 10.8 ABCB4 ABCG5 CYP7A1 NR1H4
13 10.78 ABCB4 CYP7A1 NR1H4
14 10.75 CYP7A1 NR1H4

GO Terms for Cholelithiasis

Cellular components related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 ABCB4 ABCG5 ABCG8 CCKAR SCARB1 UGT1A1
2 endocytic vesicle lumen GO:0071682 8.96 APOE HBB
3 ATP-binding cassette (ABC) transporter complex GO:0043190 8.62 ABCG5 ABCG8

Biological processes related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.88 ABCB4 ABCG5 ABCG8 SST UGT1A1
2 receptor-mediated endocytosis GO:0006898 9.83 ALB APOE HBB SCARB1
3 steroid metabolic process GO:0008202 9.79 APOE CYP7A1 UGT1A1
4 cellular oxidant detoxification GO:0098869 9.71 ALB APOE HBB
5 lipid homeostasis GO:0055088 9.67 ABCB4 APOE NR1H4
6 bile acid and bile salt transport GO:0015721 9.64 ALB NR1H4
7 cholesterol transport GO:0030301 9.63 ABCG8 SCARB1
8 drug transmembrane transport GO:0006855 9.63 ABCB4 ABCG5
9 positive regulation of nitric-oxide synthase activity GO:0051000 9.62 APOE SCARB1
10 reverse cholesterol transport GO:0043691 9.62 APOE SCARB1
11 response to nutrient GO:0007584 9.62 ABCG5 ABCG8 SST UGT1A1
12 intestinal absorption GO:0050892 9.61 ABCB4 SCARB1
13 cellular glucuronidation GO:0052695 9.6 UGT1A1 UGT1A6
14 fatty acid homeostasis GO:0055089 9.59 APOE NR1H4
15 regulation of cholesterol metabolic process GO:0090181 9.58 APOE NR1H4
16 xenobiotic glucuronidation GO:0052697 9.58 UGT1A1 UGT1A6
17 triglyceride homeostasis GO:0070328 9.58 APOE NR1H4 SCARB1
18 flavonoid glucuronidation GO:0052696 9.57 UGT1A1 UGT1A6
19 high-density lipoprotein particle clearance GO:0034384 9.56 APOE SCARB1
20 intestinal cholesterol absorption GO:0030299 9.55 ABCG5 ABCG8
21 lipid transport GO:0006869 9.55 ABCB4 ABCG5 ABCG8 APOE SCARB1
22 high-density lipoprotein particle remodeling GO:0034375 9.54 ALB APOE SCARB1
23 regulation of bile acid biosynthetic process GO:0070857 9.51 CYP7A1 NR1H4
24 negative regulation of intestinal phytosterol absorption GO:0010949 9.46 ABCG5 ABCG8
25 negative regulation of intestinal cholesterol absorption GO:0045796 9.43 ABCG5 ABCG8
26 cholesterol catabolic process GO:0006707 9.43 APOE CYP7A1 SCARB1
27 cholesterol efflux GO:0033344 9.26 ABCG5 ABCG8 APOE SCARB1
28 cholesterol homeostasis GO:0042632 9.1 ABCG5 ABCG8 APOE CYP7A1 NR1H4 SCARB1

Molecular functions related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucuronosyltransferase activity GO:0015020 9.37 UGT1A1 UGT1A6
2 antioxidant activity GO:0016209 9.32 ALB APOE
3 retinoic acid binding GO:0001972 9.26 UGT1A1 UGT1A6
4 UDP-glycosyltransferase activity GO:0008194 9.16 UGT1A1 UGT1A6
5 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCB4 ABCG5 ABCG8
6 cholesterol transporter activity GO:0017127 8.8 ABCG5 ABCG8 APOE

Sources for Cholelithiasis

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