MCID: CHL004
MIFTS: 51

Cholelithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholelithiasis

MalaCards integrated aliases for Cholelithiasis:

Name: Cholelithiasis 12 77 30 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10211
ICD9CM 36 574.5
MeSH 45 D002769
ICD10 34 K80

Summaries for Cholelithiasis

MalaCards based summary : Cholelithiasis is related to cholecystolithiasis and gallbladder disease 4. An important gene associated with Cholelithiasis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and heart, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 77 A gallstone is a stone formed within the gallbladder out of bile components. The term cholelithiasis may... more...

Related Diseases for Cholelithiasis

Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 cholecystolithiasis 32.0 ABCB4 CCK
2 gallbladder disease 4 31.9 ABCG5 ABCG8
3 cholecystitis 31.8 ABCB4 ALB CCK GPT
4 choledocholithiasis 30.8 ABCB4 ALB GPT UGT1A1
5 cholangitis 30.3 ABCB4 ALB GPT
6 liver disease 30.3 ABCB4 ALB GPT NR1H4
7 liver cirrhosis 30.3 ALB GPT SST
8 acute pancreatitis 30.2 CCK CCKAR SST
9 gilbert syndrome 30.1 UGT1A1 UGT1A6 UGT1A8
10 ascending cholangitis 30.1 ALB CCK
11 cholestasis, progressive familial intrahepatic, 3 30.1 ABCB4 ABCG8
12 postcholecystectomy syndrome 30.0 CCK SST
13 duodenogastric reflux 30.0 CCK SST
14 portal hypertension 29.9 ALB GPT SST
15 cholestasis 29.9 ABCB4 CYP7A1 GPT NR1H4
16 sclerosing cholangitis 29.8 ABCB4 ALB NR1H4
17 dyspepsia 29.8 CCK CCKAR SST
18 bilirubin metabolic disorder 29.7 ALB GPT UGT1A1 UGT1A6
19 aortic atherosclerosis 29.7 ABCG5 ABCG8
20 biliary tract disease 29.1 ABCB4 ALB CCK CYP7A1 NR1H4
21 gallbladder disease 28.7 ABCB4 ABCG5 ABCG8 CCK CCKAR UGT1A1
22 gallbladder disease 1 12.3
23 clonorchiasis 11.3
24 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 11.3
25 spherocytosis, type 1 11.0
26 overhydrated hereditary stomatocytosis 11.0
27 erythrocytosis, familial, 8 11.0
28 duodenal atresia 11.0
29 beta-thalassemia, dominant inclusion body type 11.0
30 spherocytosis, type 2 11.0
31 dehydrated hereditary stomatocytosis 2 11.0
32 sickle cell disease 10.4
33 pancreatitis 10.4
34 sickle cell anemia 10.4
35 yellow nail syndrome 10.3 ALB SST
36 crigler-najjar syndrome, type i 10.3 UGT1A1 UGT1A6
37 chylothorax, congenital 10.3 ALB SST
38 esophageal varix 10.3 ALB SST
39 pancreatic cholera 10.3 CCK SST
40 hepatic tuberculosis 10.3 ALB GPT
41 kwashiorkor 10.3 ALB GPT
42 hepatic coma 10.3 ALB GPT
43 infantile liver failure syndrome 1 10.3 ALB GPT
44 duodenal gastrinoma 10.3 CCK SST
45 descending colon cancer 10.2 UGT1A1 UGT1A6
46 thalassemia 10.2
47 functional gastric disease 10.2 CCK SST
48 fascioliasis 10.2 ALB GPT
49 pigmentation disease 10.2 UGT1A1 UGT1A6
50 autoimmune disease of urogenital tract 10.2 ABCB4 ALB

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to Cholelithiasis

Symptoms & Phenotypes for Cholelithiasis

MGI Mouse Phenotypes related to Cholelithiasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.76 ABCB4 ABCG5 ABCG8 ALB CCKAR CYP7A1
2 homeostasis/metabolism MP:0005376 9.65 ABCB4 ABCG5 ABCG8 ALB CCK CCKAR
3 liver/biliary system MP:0005370 9.23 ABCB4 ABCG5 ABCG8 ALB CCKAR CYP7A1

Drugs & Therapeutics for Cholelithiasis

Drugs for Cholelithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 262)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
2
tannic acid Approved Phase 4,Not Applicable 1401-55-4
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
5
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
6
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
7
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
8
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
9
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
10
Esketamine Approved, Investigational Phase 4 33643-46-8
11
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273
12
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
13
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
14
Nefopam Approved, Investigational Phase 4 13669-70-0
15
Clonidine Approved Phase 4 4205-90-7 2803
16
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
17
Acetaminophen Approved Phase 4 103-90-2 1983
18
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 128-13-2 31401
19
Ondansetron Approved Phase 4 99614-02-5 4595
20
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
21
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
22
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
23
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
24
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
25
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
26
Ephedrine Approved Phase 4 299-42-3 9294
27
Pseudoephedrine Approved Phase 4 90-82-4 7028
28
Bupivacaine Approved, Investigational Phase 4,Not Applicable 38396-39-3, 2180-92-9 2474
29
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
30
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
31
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
32
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
33
Etomidate Approved Phase 4 33125-97-2 667484 36339
34
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
35
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
36
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
37
Palonosetron Approved, Investigational Phase 4 135729-61-2, 135729-56-5, 119904-90-4 148211
38
Fosaprepitant Approved Phase 4 172673-20-0 219090
39
Sulbactam Approved Phase 4 68373-14-8
40
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
41
Sultamicillin Approved, Investigational Phase 4 76497-13-7
42
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
43
Taurochenodeoxycholic acid Experimental Phase 4 516-35-8 387316
44
Tauroursodeoxycholic acid Experimental, Investigational Phase 4 14605-22-2 12443252
45 Flurbiprofen axetil Investigational Phase 4 91503-79-6
46 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
47 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Antiviral Agents Phase 4
49 Cholagogues and Choleretics Phase 4,Phase 3,Phase 2,Not Applicable
50 Calamus Phase 4

Interventional clinical trials:

(show top 50) (show all 316)
# Name Status NCT ID Phase Drugs
1 The Discovery of the Double Sphincter in Gallbladder Unknown status NCT01998451 Phase 4 Tauroursodeoxycholic acid
2 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
3 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
4 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
5 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
6 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
7 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
8 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
9 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
10 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
11 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
12 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
13 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
14 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
15 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
16 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
17 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
18 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
19 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
20 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
21 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
22 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
23 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
24 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
25 Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain Completed NCT03265223 Phase 4 0.2% ropivacaine
26 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
27 Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy Completed NCT01717222 Phase 4 Intraperitoneal Lignocaine;Intravenous Lignocaine
28 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
29 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
30 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
31 PALONOSETRON X FOSAPREPITANT IN PONV Recruiting NCT03586817 Phase 4 Palonosetron;Fosaprepitant
32 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Active, not recruiting NCT03168555 Phase 4 chenodeoxycholic acid
33 COMPARISON OF INTRAOPERATIVE LOCAL ANESTHETIC APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN LAPAROSCOPIC CHOLECYSTECTOMY PATIENTS Active, not recruiting NCT03790007 Phase 4 Bupivacaine
34 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
35 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
36 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
37 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
38 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy Unknown status NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
39 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
40 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
41 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
42 Renalof in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
43 Clinical Trials for the Prevention of Gallstone Formation After Gastrectomy in Patient With Gastric Cancer Completed NCT02490111 Phase 3 DWJ1319;Placebo
44 Compare Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones Completed NCT00164853 Phase 3
45 Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery Completed NCT00835250 Phase 3
46 Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Completed NCT00370344 Phase 2, Phase 3
47 Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery for Cholecystectomy Completed NCT01558414 Phase 3
48 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
49 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy Completed NCT00447304 Phase 3 moxifloxacin
50 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: cholelithiasis

Genetic Tests for Cholelithiasis

Genetic tests related to Cholelithiasis:

# Genetic test Affiliating Genes
1 Cholelithiasis 30

Anatomical Context for Cholelithiasis

MalaCards organs/tissues related to Cholelithiasis:

42
Liver, Pancreas, Heart, Skin, Colon, Bone, Kidney

Publications for Cholelithiasis

Articles related to Cholelithiasis:

(show top 50) (show all 1545)
# Title Authors Year
1
Comparative analysis of bile acid spectrum in non-alcoholic fatty liver disease and cholelithiasis. ( 31094171 )
2019
2
Siphon-Like Gall Bladder Hydrops in Chronic Cholelithiasis. ( 31064646 )
2019
3
Lumen-apposing metal stent-assisted electrohydraulic lithotripsy and mechanical lithotripsy for cholelithiasis in a nonsurgical patient. ( 31016275 )
2019
4
Histopathological Changes in Gallbladder Mucosa Associated with Cholelithiasis: A Prospective Study. ( 31007507 )
2019
5
Incidence and Risk Factors for Cholelithiasis After Bariatric Surgery. ( 31001756 )
2019
6
Effectiveness of Ursodeoxycholic Acid in the Prevention of Cholelithiasis After Sleeve Gastrectomy. ( 30945151 )
2019
7
Interventional radiology-operated percutaneous cholecystoscopy with ultrasonic lithotripsy and stone basket retrieval: A treatment for symptomatic cholelithiasis in non-operative candidates. ( 30925003 )
2019
8
Low-Phospholipid Associated Cholelithiasis (LPAC) syndrome: A synthetic review. ( 30922600 )
2019
9
Cholelithiasis: Presentation and Management. ( 30908805 )
2019
10
Prospective observational study on cholelithiasis in patients with carcinoma gall bladder in a tertiary referral hospital of Eastern India. ( 30880772 )
2019
11
Cholesterol cholelithiasis: part of a systemic metabolic disease, prone to primary prevention. ( 30791781 )
2019
12
Systematically Characterizing Chemical Profile and Potential Mechanisms of Qingre Lidan Decoction Acting on Cholelithiasis by Integrating UHPLC-QTOF-MS and Network Target Analysis. ( 30719056 )
2019
13
Single-stage approach for the management of choledocolithiasis with concomitant cholelithiasis. Implementation of a protocol in a secondary hospital. ( 30704859 )
2019
14
LPAC syndrome: An uncommon etiology of intrahepatic cholelithiasis. ( 30528145 )
2019
15
Surgical ultrasonography at the bedside: a comparison of surgical trainees with trained sonographers for symptomatic cholelithiasis - a first Australian experience. ( 30484941 )
2019
16
Hemochromatosis associated with cholelithiasis as a cause of hydrops fetalis and stillbirth: Prenatal diagnosis. ( 30378124 )
2019
17
Laparoscopic Ultrasonography Versus Magnetic Resonance Cholangiopancreatography in Laparoscopic Surgery for Symptomatic Cholelithiasis and Suspected Common Bile Duct Stones. ( 30187333 )
2019
18
A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis. ( 30071748 )
2019
19
Ultrasound characteristics and outcome of prenatally diagnosed fetal cholelithiasis. ( 29301452 )
2019
20
Single-Stage Endoscopic Stone Extraction and Cholecystectomy during the Same Hospitalization: What is the Optimal Strategy for Patients with Choledocholithiasis and Cholelithiasis? ( 30625266 )
2019
21
Comments of manuscript: ultrasound characteristics and outcome of prenatally diagnosed fetal cholelithiasis. ( 30477362 )
2018
22
Inflammatory Pseudotumor of the Liver Presented in a Patient with Cholelithiasis. ( 30410837 )
2018
23
Risk Factors of Cholelithiasis Unrelated to Hematological Disorders in Pediatric Patients Undergoing Cholecystectomy. ( 30344805 )
2018
24
Cholelithiasis and Related Morbidity in Chronic Intestinal Failure: a Longitudinal Cohort Study from a National Specialized Centre. ( 30324401 )
2018
25
Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran. ( 30233773 )
2018
26
Diet: Cause or Consequence of the Microbial Profile of Cholelithiasis Disease? ( 30223526 )
2018
27
Association between Hashimoto's thyroiditis and cholelithiasis: a retrospective cohort study in Taiwan. ( 30185568 )
2018
28
Gallbladder agenesis mimicking cholelithiasis in an adult. ( 30167026 )
2018
29
Neonatal cholelithiasis in Down syndrome: Is hypothyroidism involved? A case-report. ( 30149478 )
2018
30
Plasma Helicobacter pylori Antibody Titers and Helicobacter pylori Infection Positivity Rates in Patients with Gallbladder Cancer or Cholelithiasis: a Hospital-Based Case-Control Study ( 30051672 )
2018
31
Symptomatic cholelithiasis in an ectopic retrocolic retroduodenal subhepatic duplicated gallbladder. ( 29997720 )
2018
32
Pocket-size ultrasound device in cholelithiasis: diagnostic accuracy and efficacy of short-term training. ( 29982876 )
2018
33
Correlation of Biliary Colic in the Absence of Cholelithiasis with Pancreaticobiliary Obstruction. ( 29981617 )
2018
34
Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden. ( 29970034 )
2018
35
Symptomatic Cholelithiasis of a Remnant Gallbladder after Open Cholecystectomy. ( 29941371 )
2018
36
Prevalence of Non-insulin-dependent Diabetes Mellitus Among Patients with Cholelithiasis: A Single-centered, Cross-sectional Study. ( 29888148 )
2018
37
Effects of gender and age on prevalence of cholelithiasis in patients with chronic HCV infection: A community-based cross-sectional study in an HCV-hyperendemic area. ( 29851796 )
2018
38
Metagenomics of Microbial Communities in Gallbladder Bile from Patients with Gallbladder Cancer or Cholelithiasis ( 29693356 )
2018
39
A New Intelligent Medical Decision Support System Based on Enhanced Hierarchical Clustering and Random Decision Forest for the Classification of Alcoholic Liver Damage, Primary Hepatoma, Liver Cirrhosis, and Cholelithiasis. ( 29599940 )
2018
40
Interventional Radiology-Operated Cholecystoscopy for the Management of Symptomatic Cholelithiasis: Approach, Technical Success, Safety, and Clinical Outcomes. ( 29547060 )
2018
41
Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study. ( 29538289 )
2018
42
Role of Cholelithiasis in Development of Portal Vein Aneurysm. ( 29454428 )
2018
43
Etiology and Outcome of Cholelithiasis in Turkish Children. ( 29242416 )
2018
44
Cholelithiasis in a Patient With History of Cholecystectomy. ( 28870658 )
2018
45
Is Concomitant Cholecystectomy Necessary for Asymptomatic Cholelithiasis During Laparoscopic Sleeve Gastrectomy? ( 28803397 )
2018
46
Single-stage management of cholelithiasis and choledocholithiasis: Laparoscopic cholecystectomy and intra-operative endoscopic sphincterotomy (with video). ( 30072276 )
2018
47
Cholelithiasis and choledocholithiasis in children; risk factors for development. ( 29763444 )
2018
48
Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta-analysis. ( 29266548 )
2018
49
Total bilirubin trend as a predictor of common bile duct stones in acute cholecystitis and symptomatic cholelithiasis. ( 29929909 )
2018
50
The association between bowel obstruction and the management of cholelithiasis and cholecystitis in elderly patients: A population-based cohort study. ( 30001868 )
2018

Variations for Cholelithiasis

Expression for Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for Cholelithiasis

Pathways related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 ABCB4 ABCG5 ABCG8 ALB CYP7A1 GPT
2
Show member pathways
12.95 CYP7A1 NR1H4 UGT1A1 UGT1A6 UGT1A8
3
Show member pathways
12.33 ABCG5 ABCG8 ALB SCARB1
4
Show member pathways
11.96 ALB CYP7A1 NR1H4
5
Show member pathways
11.69 ABCG5 ABCG8 CYP7A1 SCARB1
6
Show member pathways
11.55 UGT1A1 UGT1A6 UGT1A8
7
Show member pathways
11.28 ABCG5 ABCG8 SCARB1
8
Show member pathways
11.28 CYP7A1 UGT1A1 UGT1A6 UGT1A8
9 11.25 ABCG5 ABCG8 SCARB1
10
Show member pathways
11.11 UGT1A1 UGT1A6 UGT1A8
11 11.06 UGT1A1 UGT1A6
12 10.96 ABCB4 ABCG5 ABCG8 CYP7A1 NR1H4 SCARB1
13 10.85 UGT1A6 UGT1A8
14 10.8 ABCB4 ABCG5 CYP7A1 NR1H4
15 10.74 CYP7A1 NR1H4
16 10.71 ABCB4 CYP7A1 NR1H4

GO Terms for Cholelithiasis

Cellular components related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 ABCB4 ABCG5 ABCG8 CCKAR SCARB1 UGT1A1
2 intracellular membrane-bounded organelle GO:0043231 9.35 CYP7A1 SCARB1 UGT1A1 UGT1A6 UGT1A8
3 ATP-binding cassette (ABC) transporter complex GO:0043190 8.62 ABCG5 ABCG8

Biological processes related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 9.78 ABCB4 ABCG5 ABCG8 SCARB1
2 response to drug GO:0042493 9.77 ABCB4 ABCG5 ABCG8 SST UGT1A1
3 steroid metabolic process GO:0008202 9.74 CYP7A1 UGT1A1 UGT1A8
4 lipid homeostasis GO:0055088 9.61 ABCB4 NR1H4
5 excretion GO:0007588 9.61 ABCG5 ABCG8
6 digestion GO:0007586 9.6 CCK SST
7 response to steroid hormone GO:0048545 9.59 SST UGT1A1
8 triglyceride homeostasis GO:0070328 9.58 NR1H4 SCARB1
9 high-density lipoprotein particle remodeling GO:0034375 9.58 ALB SCARB1
10 cellular glucuronidation GO:0052695 9.56 UGT1A1 UGT1A6
11 response to nutrient GO:0007584 9.56 ABCG5 ABCG8 SST UGT1A1
12 retinoic acid metabolic process GO:0042573 9.55 UGT1A1 UGT1A8
13 cholesterol catabolic process GO:0006707 9.54 CYP7A1 SCARB1
14 intestinal cholesterol absorption GO:0030299 9.52 ABCG5 ABCG8
15 flavone metabolic process GO:0051552 9.51 UGT1A1 UGT1A8
16 cholesterol efflux GO:0033344 9.5 ABCG5 ABCG8 SCARB1
17 regulation of bile acid biosynthetic process GO:0070857 9.49 CYP7A1 NR1H4
18 negative regulation of intestinal cholesterol absorption GO:0045796 9.46 ABCG5 ABCG8
19 negative regulation of intestinal phytosterol absorption GO:0010949 9.43 ABCG5 ABCG8
20 negative regulation of steroid metabolic process GO:0045939 9.4 UGT1A1 UGT1A8
21 xenobiotic glucuronidation GO:0052697 9.33 UGT1A1 UGT1A6 UGT1A8
22 flavonoid glucuronidation GO:0052696 9.13 UGT1A1 UGT1A6 UGT1A8
23 cholesterol homeostasis GO:0042632 9.02 ABCG5 ABCG8 CYP7A1 NR1H4 SCARB1

Molecular functions related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.77 ABCG5 ABCG8 UGT1A1 UGT1A6 UGT1A8
2 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.5 ABCB4 ABCG5 ABCG8
3 steroid binding GO:0005496 9.46 UGT1A1 UGT1A8
4 fatty acid binding GO:0005504 9.43 ALB UGT1A8
5 transferase activity, transferring hexosyl groups GO:0016758 9.43 UGT1A1 UGT1A6 UGT1A8
6 cholesterol transporter activity GO:0017127 9.4 ABCG5 ABCG8
7 glucuronosyltransferase activity GO:0015020 9.33 UGT1A1 UGT1A6 UGT1A8
8 retinoic acid binding GO:0001972 9.13 UGT1A1 UGT1A6 UGT1A8
9 UDP-glycosyltransferase activity GO:0008194 8.8 UGT1A1 UGT1A6 UGT1A8

Sources for Cholelithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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