MCID: CHL004
MIFTS: 50

Cholelithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholelithiasis

MalaCards integrated aliases for Cholelithiasis:

Name: Cholelithiasis 12 76 29 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10211
ICD9CM 35 574.5
MeSH 44 D002769
ICD10 33 K80

Summaries for Cholelithiasis

MalaCards based summary : Cholelithiasis is related to cholecystolithiasis and gallbladder disease 4. An important gene associated with Cholelithiasis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Propofol and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and skin, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 76 A gallstone is a stone formed within the gallbladder out of bile components. The term cholelithiasis may... more...

Related Diseases for Cholelithiasis

Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 cholecystolithiasis 31.8 CCK ABCB4
2 gallbladder disease 4 31.6 ABCG8 ABCG5
3 cholecystitis 30.8 GPT CCK ALB ABCB4
4 choledocholithiasis 30.7 UGT1A1 GPT ALB ABCB4
5 sickle cell anemia 30.3 UGT1A6 UGT1A1 HBB
6 liver disease 30.2 NR1H4 GPT ALB ABCB4
7 cholangitis 30.1 GPT ALB ABCB4
8 cholestasis 30.0 NR1H4 GPT CYP7A1 ABCB4
9 acute pancreatitis 29.9 SST CCKAR CCK
10 ascending cholangitis 29.9 CCK ALB
11 cholestasis, progressive familial intrahepatic, 3 29.8 ABCG8 ABCB4
12 portal hypertension 29.8 SST GPT ALB
13 postcholecystectomy syndrome 29.8 SST CCK
14 duodenogastric reflux 29.7 SST CCK
15 dyspepsia 29.7 SST CCKAR CCK
16 sclerosing cholangitis 29.7 NR1H4 ALB ABCB4
17 aortic atherosclerosis 29.5 APOE ABCG8 ABCG5
18 biliary tract disease 29.3 NR1H4 CYP7A1 CCK ALB ABCB4
19 gallbladder disease 28.6 UGT1A1 SST CCKAR CCK APOE ABCG8
20 gallbladder disease 1 12.2
21 clonorchiasis 11.3
22 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 11.3
23 spherocytosis, type 1 11.0
24 overhydrated hereditary stomatocytosis 11.0
25 bisphosphoglycerate mutase deficiency 11.0
26 duodenal atresia 11.0
27 beta-thalassemia, dominant inclusion body type 11.0
28 spherocytosis, type 2 11.0
29 dehydrated hereditary stomatocytosis 2 11.0
30 sickle cell disease 10.3
31 pancreatitis 10.2
32 glucosephosphate dehydrogenase deficiency 10.2 UGT1A1 HBB
33 familial lcat deficiency 10.2 APOE ALB
34 yellow nail syndrome 10.2 SST ALB
35 sea-blue histiocyte disease 10.2 HBB APOE
36 splenic disease 10.2 HBB ALB
37 chylothorax, congenital 10.2 SST ALB
38 bilirubin, serum level of, quantitative trait locus 1 10.2 UGT1A6 UGT1A1
39 liver cirrhosis 10.2
40 thalassemia 10.2
41 pancreatic cholera 10.2 SST CCK
42 hepatic tuberculosis 10.2 GPT ALB
43 kwashiorkor 10.2 GPT ALB
44 hepatic coma 10.1 GPT ALB
45 descending colon cancer 10.1 UGT1A6 UGT1A1
46 infantile liver failure syndrome 1 10.1 GPT ALB
47 binswanger's disease 10.1 SST APOE
48 duodenal gastrinoma 10.1 SST CCK
49 duodenal disease 10.1 SST CCK
50 esophageal varix 10.1 SST ALB

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to Cholelithiasis

Symptoms & Phenotypes for Cholelithiasis

MGI Mouse Phenotypes related to Cholelithiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 ABCB4 ABCG5 ABCG8 ALB APOE CCKAR
2 endocrine/exocrine gland MP:0005379 9.7 ABCB4 ALB APOE CCK CCKAR NR1H4
3 homeostasis/metabolism MP:0005376 9.7 ABCB4 ABCG5 ABCG8 ALB APOE CCK
4 liver/biliary system MP:0005370 9.28 ABCB4 ABCG5 ABCG8 ALB APOE CCKAR

Drugs & Therapeutics for Cholelithiasis

Drugs for Cholelithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 247)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
2 tannic acid Approved Phase 4
3
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
8
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
9
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
10
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
11
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
12
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273
13
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
14 Nefopam Approved, Investigational Phase 4 13669-70-0
15
Clonidine Approved Phase 4 4205-90-7 2803
16
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
17
Acetaminophen Approved Phase 4 103-90-2 1983
18
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 128-13-2 31401
19
Ondansetron Approved Phase 4 99614-02-5 4595
20
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
21
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
22
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
23
Pseudoephedrine Approved Phase 4 90-82-4 7028
24
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
25
Morphine Approved, Investigational Phase 4 57-27-2 5288826
26
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
27
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
28
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
29
Ephedrine Approved Phase 4 299-42-3 9294
30
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
31
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
32
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
33
Etomidate Approved Phase 4 33125-97-2 667484 36339
34
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
35
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
36
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-61-2, 135729-56-5 148211
37
Fosaprepitant Approved Phase 4 172673-20-0 219090
38
Sultamicillin Approved, Investigational Phase 4 76497-13-7
39
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
40
Sulbactam Approved Phase 4 68373-14-8
41
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
42
Tauroursodeoxycholic acid Experimental, Investigational Phase 4 14605-22-2 12443252
43
Substance P Investigational Phase 4 33507-63-0 44359816
44 Taurochenodeoxycholic Acid Phase 4
45 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
47 Cholagogues and Choleretics Phase 4,Phase 3,Phase 2,Not Applicable
48 Antiviral Agents Phase 4
49 Calamus Phase 4
50 Central Nervous System Depressants Phase 4,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 301)
# Name Status NCT ID Phase Drugs
1 The Discovery of the Double Sphincter in Gallbladder Unknown status NCT01998451 Phase 4 Tauroursodeoxycholic acid
2 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
3 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
4 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
5 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
6 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
7 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
8 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
9 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
10 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
11 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
12 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
13 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
14 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
15 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
16 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
17 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
18 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
19 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
20 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
21 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
22 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
23 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
24 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
25 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
26 Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain Completed NCT03265223 Phase 4 0.2% ropivacaine
27 Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy Completed NCT01717222 Phase 4 Intraperitoneal Lignocaine;Intravenous Lignocaine
28 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
29 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
30 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
31 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Active, not recruiting NCT03168555 Phase 4 chenodeoxycholic acid
32 COMPARISON OF INTRAOPERATIVE LOCAL ANESTHETIC APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN LAPAROSCOPIC CHOLECYSTECTOMY PATIENTS Active, not recruiting NCT03790007 Phase 4 Bupivacaine
33 PALONOSETRON X FOSAPREPITANT IN PONV Not yet recruiting NCT03586817 Phase 4 Palonosetron;Fosaprepitant
34 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
35 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
36 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
37 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
38 Clinical Trials for the Prevention of Gallstone Formation After Gastrectomy in Patient With Gastric Cancer Unknown status NCT02490111 Phase 3 DWJ1319;Placebo
39 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
40 Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy Unknown status NCT01383031 Phase 2, Phase 3
41 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
42 Renalof in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
43 Compare Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones Completed NCT00164853 Phase 3
44 Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery Completed NCT00835250 Phase 3
45 Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Completed NCT00370344 Phase 2, Phase 3
46 Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery for Cholecystectomy Completed NCT01558414 Phase 3
47 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
48 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy Completed NCT00447304 Phase 3 moxifloxacin
49 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
50 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: cholelithiasis

Genetic Tests for Cholelithiasis

Genetic tests related to Cholelithiasis:

# Genetic test Affiliating Genes
1 Cholelithiasis 29

Anatomical Context for Cholelithiasis

MalaCards organs/tissues related to Cholelithiasis:

41
Liver, Pancreas, Skin, Kidney, Heart, Colon, B Cells

Publications for Cholelithiasis

Articles related to Cholelithiasis:

(show top 50) (show all 1051)
# Title Authors Year
1
Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta-analysis. ( 29266548 )
2018
2
Ultrasound characteristics and outcome of prenatally diagnosed fetal cholelithiasis. ( 29301452 )
2018
3
Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study. ( 29538289 )
2018
4
Total bilirubin trend as a predictor of common bile duct stones in acute cholecystitis and symptomatic cholelithiasis. ( 29929909 )
2018
5
Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden. ( 29970034 )
2018
6
Role of Cholelithiasis in Development of Portal Vein Aneurysm. ( 29454428 )
2018
7
Cholelithiasis and choledocholithiasis in children; risk factors for development. ( 29763444 )
2018
8
Effects of gender and age on prevalence of cholelithiasis in patients with chronic HCV infection: A community-based cross-sectional study in an HCV-hyperendemic area. ( 29851796 )
2018
9
Prevalence of Non-insulin-dependent Diabetes Mellitus Among Patients with Cholelithiasis: A Single-centered, Cross-sectional Study. ( 29888148 )
2018
10
Symptomatic Cholelithiasis of a Remnant Gallbladder after Open Cholecystectomy. ( 29941371 )
2018
11
Interventional Radiology-Operated Cholecystoscopy for the Management of Symptomatic Cholelithiasis: Approach, Technical Success, Safety, and Clinical Outcomes. ( 29547060 )
2018
12
Metagenomics of Microbial Communities in Gallbladder Bile from Patients with Gallbladder Cancer or Cholelithiasis ( 29693356 )
2018
13
The association between bowel obstruction and the management of cholelithiasis and cholecystitis in elderly patients: A population-based cohort study. ( 30001868 )
2018
14
Single-stage management of cholelithiasis and choledocholithiasis: Laparoscopic cholecystectomy and intra-operative endoscopic sphincterotomy (with video). ( 30072276 )
2018
15
A New Intelligent Medical Decision Support System Based on Enhanced Hierarchical Clustering and Random Decision Forest for the Classification of Alcoholic Liver Damage, Primary Hepatoma, Liver Cirrhosis, and Cholelithiasis. ( 29599940 )
2018
16
Correlation of Biliary Colic in the Absence of Cholelithiasis with Pancreaticobiliary Obstruction. ( 29981617 )
2018
17
Pocket-size ultrasound device in cholelithiasis: diagnostic accuracy and efficacy of short-term training. ( 29982876 )
2018
18
Symptomatic cholelithiasis in an ectopic retrocolic retroduodenal subhepatic duplicated gallbladder. ( 29997720 )
2018
19
Plasma Helicobacter pylori Antibody Titers and Helicobacter pylori Infection Positivity Rates in Patients with Gallbladder Cancer or Cholelithiasis: a Hospital-Based Case-Control Study ( 30051672 )
2018
20
A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis. ( 30071748 )
2018
21
Neonatal cholelithiasis in Down syndrome: Is hypothyroidism involved? A case-report. ( 30149478 )
2018
22
Gallbladder agenesis mimicking cholelithiasis in an adult. ( 30167026 )
2018
23
Association between Hashimoto's thyroiditis and cholelithiasis: a retrospective cohort study in Taiwan. ( 30185568 )
2018
24
Laparoscopic Ultrasonography Versus Magnetic Resonance Cholangiopancreatography in Laparoscopic Surgery for Symptomatic Cholelithiasis and Suspected Common Bile Duct Stones. ( 30187333 )
2018
25
Diet: Cause or Consequence of the Microbial Profile of Cholelithiasis Disease? ( 30223526 )
2018
26
Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran. ( 30233773 )
2018
27
Cholelithiasis and Related Morbidity in Chronic Intestinal Failure: a Longitudinal Cohort Study from a National Specialized Centre. ( 30324401 )
2018
28
Risk Factors of Cholelithiasis Unrelated to Hematological Disorders in Pediatric Patients Undergoing Cholecystectomy. ( 30344805 )
2018
29
Hemochromatosis associated with cholelithiasis as a cause of hydrops fetalis and stillbirth: Prenatal diagnosis. ( 30378124 )
2018
30
Inflammatory Pseudotumor of the Liver Presented in a Patient with Cholelithiasis. ( 30410837 )
2018
31
Comments of manuscript: ultrasound characteristics and outcome of prenatally diagnosed fetal cholelithiasis. ( 30477362 )
2018
32
Surgical ultrasonography at the bedside: a comparison of surgical trainees with trained sonographers for symptomatic cholelithiasis - a first Australian experience. ( 30484941 )
2018
33
LPAC syndrome: An uncommon etiology of intrahepatic cholelithiasis. ( 30528145 )
2018
34
Cholelithiasis ( 29262107 )
2017
35
Factors affecting the conversion to open surgery during laparoscopic cholecystectomy in patients with cholelithiasis undergoing ERCP due to choledocholithiasis. ( 28874623 )
2017
36
Miniinvasive surgical interventions in management of cholelithiasis A retrospective study. ( 28604381 )
2017
37
Cholecystolithotomy Combined Armillarisin A versus Cholecystectomy in Cirrhotic Portal Hypertension Patients with Symptomatic Cholelithiasis. ( 28463673 )
2017
38
Is Concomitant Cholecystectomy Necessary for Asymptomatic Cholelithiasis During Laparoscopic Sleeve Gastrectomy? ( 28803397 )
2017
39
Is the oral contraceptive or hormone replacement therapy a risk factor for cholelithiasis: A systematic review and meta-analysis. ( 28383429 )
2017
40
Don't put off until tomorrow what you can do today: Early cholecystectomy is cost-effective in symptomatic cholelithiasis requiring hospitalization. ( 29133302 )
2017
41
Fetal Cholelithiasis: Antenatal Diagnosis and Neonatal Follow-Up in a Case of Twin Pregnancy - A Case Report and Review of the Literature. ( 28210714 )
2017
42
Pre- and Post-operative Comparative Analysis of Serum Lipid Profile in Patients with Cholelithiasis. ( 28904919 )
2017
43
Associations between serum leptin levels, hyperlipidemia, and cholelithiasis in dogs. ( 29088261 )
2017
44
Effectiveness of Ultrasound Shear for Clipless Laparoscopic Cholecystectomy Versus Conventional Unipolar Electrocautery in Patients with Cholelithiasis. ( 29056121 )
2017
45
Physical Chemistry of Bile: Detailed Pathogenesis of Cholelithiasis. ( 28350710 )
2017
46
Intrahepatic cholelithiasis in dogs and cats: A case series. ( 28878422 )
2017
47
Single Stage Management of Concomitant Cholelithiasis and Choledocholithiasis. ( 28598447 )
2017
48
Cholecystoduodenal fistula, an infrequent complication of cholelithiasis: Our experience in its surgical management. ( 28389051 )
2017
49
Cholelithiasis. ( 28745992 )
2017
50
Do Alpha Thalassemia, Fetal Hemoglobin, and the UGT1A1 Polymorphism have an Influence on Serum Bilirubin Levels and Cholelithiasis in Patients with Sickle Cell Disease? ( 28567595 )
2017

Variations for Cholelithiasis

Expression for Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for Cholelithiasis

Pathways related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 ABCB4 ABCG5 ABCG8 ALB APOE CYP7A1
2
Show member pathways
12.34 ABCG5 ABCG8 ALB APOE SCARB1
3 12.3 APOE HBB UGT1A1 UGT1A6
4
Show member pathways
12.11 ALB APOE HBB SCARB1
5
Show member pathways
11.96 ALB CYP7A1 NR1H4
6
Show member pathways
11.69 ALB APOE HBB SCARB1
7
Show member pathways
11.63 ABCG5 ABCG8 APOE CYP7A1 SCARB1
8
Show member pathways
11.49 CYP7A1 UGT1A1 UGT1A6
9
Show member pathways
11.28 ABCG5 ABCG8 SCARB1
10 11.25 ABCG5 ABCG8 SCARB1
11 11.05 UGT1A1 UGT1A6
12 10.95 ABCB4 ABCG5 ABCG8 CYP7A1 NR1H4 SCARB1
13 10.8 ABCB4 ABCG5 CYP7A1 NR1H4
14 10.78 ABCB4 CYP7A1 NR1H4
15 10.75 CYP7A1 NR1H4

GO Terms for Cholelithiasis

Cellular components related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 ABCB4 ABCG5 ABCG8 CCKAR SCARB1 UGT1A1
2 blood microparticle GO:0072562 9.43 ALB APOE HBB
3 endocytic vesicle lumen GO:0071682 8.96 APOE HBB
4 ATP-binding cassette (ABC) transporter complex GO:0043190 8.62 ABCG5 ABCG8

Biological processes related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.88 ABCB4 ABCG5 ABCG8 SST UGT1A1
2 receptor-mediated endocytosis GO:0006898 9.84 ALB APOE HBB SCARB1
3 steroid metabolic process GO:0008202 9.79 APOE CYP7A1 UGT1A1
4 cellular oxidant detoxification GO:0098869 9.73 ALB APOE HBB
5 lipid homeostasis GO:0055088 9.69 ABCB4 APOE NR1H4
6 triglyceride homeostasis GO:0070328 9.67 APOE NR1H4 SCARB1
7 response to nutrient GO:0007584 9.67 ABCG5 ABCG8 SST UGT1A1
8 digestion GO:0007586 9.63 CCK SST
9 response to steroid hormone GO:0048545 9.63 SST UGT1A1
10 positive regulation of nitric-oxide synthase activity GO:0051000 9.62 APOE SCARB1
11 reverse cholesterol transport GO:0043691 9.62 APOE SCARB1
12 fatty acid homeostasis GO:0055089 9.61 APOE NR1H4
13 cellular glucuronidation GO:0052695 9.6 UGT1A1 UGT1A6
14 regulation of cholesterol metabolic process GO:0090181 9.59 APOE NR1H4
15 xenobiotic glucuronidation GO:0052697 9.58 UGT1A1 UGT1A6
16 high-density lipoprotein particle clearance GO:0034384 9.58 APOE SCARB1
17 drug transmembrane transport GO:0006855 9.58 ABCB4 ABCG5 ABCG8
18 intestinal cholesterol absorption GO:0030299 9.57 ABCG5 ABCG8
19 flavonoid glucuronidation GO:0052696 9.55 UGT1A1 UGT1A6
20 lipid transport GO:0006869 9.55 ABCB4 ABCG5 ABCG8 APOE SCARB1
21 regulation of bile acid biosynthetic process GO:0070857 9.52 CYP7A1 NR1H4
22 high-density lipoprotein particle remodeling GO:0034375 9.5 ALB APOE SCARB1
23 negative regulation of intestinal cholesterol absorption GO:0045796 9.46 ABCG5 ABCG8
24 negative regulation of intestinal phytosterol absorption GO:0010949 9.43 ABCG5 ABCG8
25 cholesterol catabolic process GO:0006707 9.43 APOE CYP7A1 SCARB1
26 cholesterol efflux GO:0033344 9.26 ABCG5 ABCG8 APOE SCARB1
27 cholesterol homeostasis GO:0042632 9.1 ABCG5 ABCG8 APOE CYP7A1 NR1H4 SCARB1

Molecular functions related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucuronosyltransferase activity GO:0015020 9.4 UGT1A1 UGT1A6
2 antioxidant activity GO:0016209 9.37 ALB APOE
3 retinoic acid binding GO:0001972 9.32 UGT1A1 UGT1A6
4 UDP-glycosyltransferase activity GO:0008194 9.26 UGT1A1 UGT1A6
5 drug transmembrane transporter activity GO:0015238 9.16 ABCG5 ABCG8
6 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCB4 ABCG5 ABCG8
7 cholesterol transporter activity GO:0017127 8.8 ABCG5 ABCG8 APOE

Sources for Cholelithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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