MCID: CHL004
MIFTS: 48

Cholelithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholelithiasis

MalaCards integrated aliases for Cholelithiasis:

Name: Cholelithiasis 12 73 54 15 17 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10211
ICD9CM 34 574.5
SNOMED-CT 67 197397004
ICD10 32 K80
UMLS 70 C0006739 C0008350

Summaries for Cholelithiasis

MalaCards based summary : Cholelithiasis is related to gallbladder disease 4 and cholecystitis. An important gene associated with Cholelithiasis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Ropivacaine and Flurbiprofen have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and kidney, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Wikipedia : 73 A gallstone is a stone formed within the gallbladder out of precipitated bile components. The term... more...

Related Diseases for Cholelithiasis

Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 590)
# Related Disease Score Top Affiliating Genes
1 gallbladder disease 4 31.8 ABCG8 ABCG5
2 cholecystitis 31.6 GPT CCKAR CCK ALB ABCB4
3 cholecystolithiasis 31.5 SST GPT CRP CCK ABCB4
4 choledocholithiasis 30.9 UGT1A1 GPT CRP CCK ALB ABCB4
5 cholangitis 30.9 NR1H4 GPT CRP ALB ABCB4
6 obstructive jaundice 30.9 GPT CRP ALB
7 intestinal obstruction 30.8 GPT CRP ALB
8 postcholecystectomy syndrome 30.7 GAST CCK
9 bile duct cysts 30.7 GPT ALB ABCB4
10 ileus 30.7 SST INS CRP CCK
11 pancreatitis 30.6 SST INS CRP CCK
12 biliary dyskinesia 30.6 SST GPT CCK
13 cholestasis 30.6 NR1H4 GPT CYP7A1 CCK ALB ABCB4
14 hereditary spherocytosis 30.6 UGT1A8 UGT1A6 UGT1A1 HBB
15 duodenal ulcer 30.6 SST INS GAST CCK
16 liver cirrhosis 30.5 SST INS GPT CRP ALB
17 acute cholangitis 30.4 GPT CRP ALB
18 pleural empyema 30.4 GPT CRP ALB
19 intrahepatic cholestasis of pregnancy 30.4 NR1H4 GPT APOE ABCB4
20 gilbert syndrome 30.4 UGT1A8 UGT1A6 UGT1A1 GPT ALB
21 duodenal obstruction 30.3 CRP ALB
22 acute pancreatitis 30.3 SST INS GPT CRP CCKAR CCK
23 sickle cell anemia 30.3 UGT1A8 UGT1A6 UGT1A1 HBB GPT CRP
24 acalculous cholecystitis 30.3 GPT CRP CCKAR CCK ALB
25 liver disease 30.3 UGT1A1 NR1H4 INS GPT ALB ABCB4
26 portal hypertension 30.2 SST NR1H4 INS GPT ALB
27 hepatic encephalopathy 30.2 SST GPT ALB
28 suppurative cholangitis 30.2 GPT CRP ABCB4
29 hemoglobinopathy 30.2 UGT1A1 INS HBB CRP ALB
30 duodenogastric reflux 30.2 SST GAST CCK
31 sclerosing cholangitis 30.2 NR1H4 GPT ALB ABCB4
32 leptin deficiency or dysfunction 30.1 INS CRP CCKAR CCK
33 beta-thalassemia 30.0 UGT1A1 INS HBB GPT CRP
34 ascending cholangitis 30.0 GPT CRP ALB
35 pyelonephritis 30.0 GPT CRP ALB
36 deficiency anemia 30.0 INS HBB GPT CRP ALB
37 carcinoid tumors, intestinal 29.9 SST GAST
38 autonomic neuropathy 29.9 INS GAST CCK ALB
39 glucosephosphate dehydrogenase deficiency 29.9 UGT1A8 UGT1A6 UGT1A1 HBB ALB
40 short bowel syndrome 29.9 SST GAST CCK
41 emphysematous cholecystitis 29.9 GPT CRP
42 aortic atherosclerosis 29.9 APOE ABCG8 ABCG5
43 thyroid carcinoma, familial medullary 29.9 SST GAST CCK
44 coronary heart disease 1 29.9 INS CRP APOE
45 diarrhea 29.9 UGT1A1 SST GPT GAST CCK ALB
46 biliary tract disease 29.9 NR1H4 GPT CYP7A1 CRP CCK ALB
47 cholestasis, progressive familial intrahepatic, 3 29.8 NR1H4 CYP7A1 ABCG8 ABCG5 ABCB4
48 primary biliary cholangitis 29.8 NR1H4 GPT CYP7A1 ALB ABCB4
49 bile reflux 29.8 NR1H4 GAST CCK ALB
50 esophageal varix 29.8 SST INS GPT ALB

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to Cholelithiasis

Symptoms & Phenotypes for Cholelithiasis

MGI Mouse Phenotypes related to Cholelithiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 ABCB4 ABCG5 ABCG8 ALB APOE CCK
2 digestive/alimentary MP:0005381 10 ABCB4 ABCG5 ABCG8 ALB APOE CCKAR
3 immune system MP:0005387 9.77 ABCB4 ABCG5 ABCG8 ALB APOE CCK
4 liver/biliary system MP:0005370 9.32 ABCB4 ABCG5 ABCG8 ALB APOE CCKAR

Drugs & Therapeutics for Cholelithiasis

Drugs for Cholelithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 130)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
2
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
3
tannic acid Approved Phase 4 1401-55-4
4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
5
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
6
Esketamine Approved, Investigational Phase 4 33643-46-8
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
8
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
9
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
10
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
11
Ondansetron Approved Phase 4 99614-02-5 4595
12
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
13
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
14
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
16
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
17
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
18
Ephedrine Approved Phase 4 299-42-3 9294
19
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
20
Esmolol Approved Phase 4 81147-92-4, 103598-03-4 59768
21
Morphine Approved, Investigational Phase 4 57-27-2 5288826
22
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
23
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
24
Pseudoephedrine Approved Phase 4 90-82-4 7028
25
Remifentanil Approved Phase 4 132875-61-7 60815
26
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
27
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
28
Sulbactam Approved Phase 4 68373-14-8
29
Sultamicillin Approved, Investigational Phase 4 76497-13-7
30
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
31
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
32
Flurbiprofen axetil Investigational Phase 4 91503-79-6
33
Tauroursodeoxycholic acid Experimental, Investigational Phase 4 14605-22-2 12443252
34 Anesthetics, Local Phase 4
35 Antiviral Agents Phase 4
36 Dopamine Agents Phase 4
37 Dopamine Antagonists Phase 4
38 Excitatory Amino Acid Antagonists Phase 4
39 Antidepressive Agents Phase 4
40 Anesthetics, Dissociative Phase 4
41 Anticonvulsants Phase 4
42 Anti-Arrhythmia Agents Phase 4
43 Sodium Channel Blockers Phase 4
44 Diuretics, Potassium Sparing Phase 4
45 Psychotropic Drugs Phase 4
46 Antiemetics Phase 4
47 Neurotransmitter Agents Phase 4
48 Anti-Anxiety Agents Phase 4
49 Antipsychotic Agents Phase 4
50 Dermatologic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 176)
# Name Status NCT ID Phase Drugs
1 Laparo-endoscopic Single Site Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT01339325 Phase 4
2 Randomised Controlled Trail of Warmed Humidified Insufflation Versus Cold Non-Humidified Insufflation in Elective Laparoscopic Cholecystectomies: Does This Reduce Post-Operative Pain? Unknown status NCT00792389 Phase 4
3 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
4 Closed-Loop Target Controlled Infusion of Propofol and Remifentanil Guided by Narcotrend Index in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
5 The Discovery of the Double Sphincter in Gallbladder Unknown status NCT01998451 Phase 4 Tauroursodeoxycholic acid
6 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
7 Effect of Endovenous Lidocaine on Analgesia and Serum Cytokines Concentration: Randomized and Double-blind Trial Completed NCT02363699 Phase 4 Lidocaine;Saline solution
8 Study of Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy for Uncomplicated Cholelithiasis (Lap vs SILS) Completed NCT01211743 Phase 4
9 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy: A Randomized Trial Completed NCT01397565 Phase 4
10 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
11 Effects of Intraperitoneal Levobupivacaine on Pain After Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blinded Study Completed NCT00836316 Phase 4 levobupivacaine
12 Multi-Port vs. Single-port Cholecystectomy Completed NCT01104727 Phase 4
13 Granisetron Effect on Hemodynamic Changes and Intubation Condition During Anesthesia Induction in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
14 Laparoscopic Guided Regional Analgesia (LaGRA) Reduces Post Operative Pain After Laparoscopic Cholecystectomy - a Randomised, Controlled Trial. Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
15 Combined Preincisional Infiltration and Intraperitoneal Instillation of Levobupivacaine for Postoperative Pain Reduction After Laparoscopic Cholecystectomy; A Double-blind Placebo-controlled Randomised Clinical Trial Completed NCT01199406 Phase 4 Levobupivacaine
16 Robotic Assisted Versus Laparoscopic Cholecystectomy - Completed NCT00562900 Phase 4
17 Cholecystocholangiography Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy: A Prospective Controlled Randomized Trial Completed NCT01103570 Phase 4
18 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy: a Randomized Clinical Trial Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
19 Studie Naar De Effectiviteit Van Ursodeoxycholzuur Ter Preventie Van Galsteen-Gerelateerde Klachten Bij patiënten in Afwachting Van Een Cholecystectomie Completed NCT00161083 Phase 4 ursodeoxycholic acid
20 Dual-Loop Target Controlled Infusion of Propofol and Remifentanil Guided by Narcotrend Index in Laparoscopic Cholecystectomy Completed NCT02116985 Phase 4
21 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Completed NCT03168555 Phase 4 chenodeoxycholic acid
22 Is an Antibiotic Prescription Required After Laparoscopic Cholecystectomy for Acute Calculous Cholecystitis? Not yet recruiting NCT04290104 Phase 4 1gr oral ampicillin/sulbactam group
23 DOLCE Study: Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized, Controlled Trial Not yet recruiting NCT01052727 Phase 4
24 Biliary Lithotripsy in Combination With Actigall Versus Actigall Monotherapy for the Treatment of Symptomatic Cholesterol Gallstones Terminated NCT00042549 Phase 4 ursodiol
25 Ciprofloxacin, Ampicillin-sulbactam and Placebo Prophylaxis in Laparoscopic Cholecystectomy. A Randomized Controlled Study Terminated NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
26 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
27 Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
28 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy: A Prospective Randomized Multicenter Placebo-Controlled Trial Unknown status NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
29 Single Port Access Cholecystectomy Versus Standard Laparoscopic Cholecystectomy - Randomized Study Unknown status NCT00904865 Phase 2, Phase 3
30 Prospective Randomized Clinical Trial Comparing Laparoscopic Cholecystectomy and Hybrid Natural Orifice Translumenal Endoscopic Surgery (NOTES) Completed NCT00835250 Phase 3
31 Efficacy and Safety of Renalof Administration in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
32 Prospective Randomized Clinical Trial Comparing Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery on Cholecystectomy Completed NCT01558414 Phase 3
33 An Expertise-based Randomized Controlled Trial Comparing Minilaparotomy Cholecystectomy and Laparoscopic Cholecystectomy Completed NCT00370344 Phase 2, Phase 3
34 Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones-a Randomized Controlled Trial Completed NCT00164853 Phase 3
35 Treatment of Suspected Cholelithiasis With Nitroglycerin: a Randomized, Prospective Double-blind Trial Unknown status NCT01715220 Phase 2 sublingual nitroglycerine
36 Transvaginal Natural Orifice Translumenal and Endoscopic Surgery (NOTES) Cholecystectomy vs. Laparoscopic Cholecystectomy: Phase I/II Clinical Trial Completed NCT00710502 Phase 1, Phase 2
37 Effects of Obeticholic Acid on Hepatic Fatty Acid/Triglyceride Metabolism and Hepatobiliary Detoxification/Elimination in Morbidly Obese and Gallstone Patients Completed NCT01625026 Phase 2 Obeticholic acid;Placebo
38 Natural Orifice Translumenal Endoscopic Surgery: Laparoscopic-Assisted Transvaginal Cholecystectomy Terminated NCT00910325 Phase 1, Phase 2
39 Medical Dissolution of Cholesterol Gallstones Using Oral Aramchol - A Proof of Concept Phase IIa Study Terminated NCT02325492 Phase 2 Aramchol;Placebo
40 A Phase 1, 2-Part, Randomized, Subject And Investigator Blinded, Placebo-Controlled, Cross-Over Trial To Evaluate The Safety, Tolerability And Pharmacokinetics Of CE-326,597 In Obese, Adult Subjects With Asymptomatic Cholelithiasis Completed NCT00576589 Phase 1 CE-326,597;Placebo
41 Single Incision Laparoscopic Cholecystectomy Completed NCT00678873 Phase 1
42 Laparoscopic Cholecystectomy Using Transvaginal Endoscopic Assistance Withdrawn NCT00815438 Phase 1
43 Prospective Randomized Clinical Study for Timing of Laparoscopic Cholecystectomy After Endoscopic Retrograde Cholangiography for Acute Biliary Pancreatitis Unknown status NCT01687959 Early Phase 1
44 Natural Orifice Translumenal Endoscopic Surgery (NOTES): Laparoscopic Assisted Transgastric Appendectomy and Cholecystectomy Unknown status NCT00531219
45 Clinical Application of Cholangiojejunostomy in the Surgical Treatment of Cholelithiasis With Moderate Dilatation of Common Bile Duct Unknown status NCT02915770
46 Laparoendoscopic Rendez Vous (Intraoperative ERCP) vs Two Stage Approach (Preoperative ERCP Followed by Laparoscopic Cholecystectomy) for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234
47 Proficiency-based Versus Free Laparoscopic Training in Cholecystectomy Using the Simbionix LAP Mentor™. A Randomized Controlled Trial Unknown status NCT01615549
48 The Study of Laparoscope Combined Ureteroscopic Air-pressure Ballistic Lithotripsy to Treat Patients With Hepatolithiasis Unknown status NCT02127242
49 Three-dimensional High-definition (3DHD) Laparoscopy Versus Two-dimensional High-definition (2DHD) Laparoscopy in Cholecystectomy: a Clinical Controlled Randomized Double Blinded Trial. Unknown status NCT02396927
50 Study of Relationship Between Gallstones and Concomitant Gastric Helicobacter Pylori Infection Unknown status NCT01810081

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Ursodiol

Genetic Tests for Cholelithiasis

Anatomical Context for Cholelithiasis

MalaCards organs/tissues related to Cholelithiasis:

40
Pancreas, Liver, Kidney, Heart, Colon, Pituitary, Bone

Publications for Cholelithiasis

Articles related to Cholelithiasis:

(show top 50) (show all 8217)
# Title Authors PMID Year
1
Cholelithiasis, cholecystectomy, and liver disease. 61 54
20068558 2010
2
The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects. 54 61
20422496 2010
3
Combined features of low phospholipid-associated cholelithiasis and progressive familial intrahepatic cholestasis 3. 54 61
19840255 2010
4
Acute transient hepatocellular injury in cholelithiasis and cholecystitis without evidence of choledocholithiasis. 61 54
19673021 2009
5
ABCB4 sequence variations in young adults with cholesterol gallstone disease. 54 61
19018976 2009
6
Gilbert syndrome as a predisposing factor for cholelithiasis risk in the Greek adult population. 54 61
19309288 2009
7
Association between promoter and coding region mutations of UDP-glucuronosyltransferase 1A1 and beta-thalassemia/Hb E with cholelithiasis. 61 54
18081723 2008
8
Early modification of sickle cell disease clinical course by UDP-glucuronosyltransferase 1A1 gene promoter polymorphism. 54 61
18392554 2008
9
[Recurrent intrahepatic cholestasis of pregnancy and chain-like choledocholithiasis in a female patient with stop codon in the ABDC4-gene of the hepatobiliary phospholipid transporter]. 54 61
18188816 2008
10
MDR3 mutations associated with intrahepatic and gallbladder cholesterol cholelithiasis: an update. 54 61
17786139 2007
11
Reproduction of postprandial symptoms with cholecystokinin injection: an indication for cholecystectomy without the presence of gallstones or an abnormal ejection fraction on quantitative cholescintigraphy? 61 54
17674942 2007
12
The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease. 61 54
17593033 2007
13
[Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease]. 61 54
17438969 2007
14
Acute recurrent biliary pancreatitis associated with the ABCB4 gene mutation. 54 61
17273143 2007
15
UGT1A1 polymorphism outweighs the modest effect of deletional (-3.7 kb) alpha-thalassemia on cholelithogenesis in sickle cell anemia. 54 61
16628735 2006
16
Effects of variant UDP-glucuronosyltransferase 1A1 gene, glucose-6-phosphate dehydrogenase deficiency and thalassemia on cholelithiasis. 54 61
16237771 2005
17
Association of UGT1A1 polymorphism with prevalence and age at onset of cholelithiasis in sickle cell anemia. 54 61
15710570 2005
18
[Low density lipoproteins in patients with cholelithiasis and cholesterosis of the gallbladder]. 54 61
15807442 2005
19
Sincalide in patients with parenteral nutrition-associated gallbladder disease. 61 54
15316105 2004
20
Biliary dyskinesia: a potentially unrecognized cause of abdominal pain in children. 54 61
15322841 2004
21
Gilbert's syndrome as a predisposing factor for idiopathic cholelithiasis in children. 54 61
14555319 2003
22
Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium. 54 61
12801960 2003
23
A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis. 61 54
12671900 2003
24
Influence of bilirubin uridine diphosphate-glucuronosyltransferase 1A promoter polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia. 54 61
11878580 2001
25
MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. 61 54
11313316 2001
26
Cholelithiasis in a newborn following treatment with the somatostatin analogue octreotide. 61 54
10923237 2000
27
[Alpha-L-fucosidase activity in patients with ductal cholelithiasis]. 54 61
9695655 1998
28
Study of the secretion of substance P, neurotensin and somatostatin in patients with cholelithiasis. 61 54
9253232 1997
29
Plasma cholecystokinin levels in acute pancreatitis. 54 61
9094154 1997
30
Different pathways mediate cholecystokinin actions in cholelithiasis. 61 54
9142916 1997
31
Cholelithiasis in Taiwan. Gallstone characteristics, surgical incidence, bile lipid composition, and role of beta-glucuronidase. 61 54
7555451 1995
32
Carcinoembryonic antigen (CEA) and CEA-related substances in the bile of patients with biliary diseases. 61 54
8160902 1994
33
Development and optimization of an enzyme-linked immunosorbent assay employing two murine monoclonal antibodies for absolute quantitation of human beta-glucuronidase. 61 54
1418687 1992
34
A large-scale purification of beta-glucuronidase from human liver by immunoaffinity chromatography. 54 61
1777114 1991
35
Rapid purification of beta-glucuronidase from human liver by immunoaffinity chromatography employing specific murine monoclonal IgG binding to tresyl-activated agarose. 61 54
1821773 1991
36
Carcinoid tumors of the duodenum. A clinicopathologic study of 99 cases. 54 61
1694655 1990
37
[Plasma levels of various gastrointestinal polypeptides in patients with cholelithiasis and different degree of functional disorders of the major duodenal papilla]. 61 54
2278184 1990
38
A review of plant characteristics, phytochemistry and bioactivities of the genus Glechoma. 61
33465438 2021
39
Influence of UGT1A1 promoter polymorphism, α-thalassemia and βs haplotype in bilirubin levels and cholelithiasis in a large sickle cell anemia cohort. 61
33523291 2021
40
Low-phospholipid-associated cholelithiasis syndrome: Prevalence, clinical features, and comorbidities. 61
33554096 2021
41
Biliary adverse events in acromegaly during somatostatin receptor ligands: predictors of onset and response to ursodeoxycholic acid treatment. 61
33164134 2021
42
Alpha thalassemia, but not βS-globin haplotypes, influence sickle cell anemia clinical outcome in a large, single-center Brazilian cohort. 61
33586016 2021
43
Laparoscopic approach in cholecystogastric fistula with cholecystectomy and omental patching: A case report and review. 61
32964876 2021
44
Hereditary spherocytosis diagnosed with extremely low glycated hemoglobin compared to plasma glucose levels. 61
33786277 2021
45
Meta-analysis and trial sequential analysis of three-port vs four-port laparoscopic cholecystectomy (level 1 evidence). 61
33587285 2021
46
Diagnosis-Related Group (DRG)-Based Prospective Hospital Payment System can be well adopted for Acute Care Surgery: Taiwanese Experience with Acute Cholecystitis. 61
33454793 2021
47
Development of an artificial intelligence system using deep learning to indicate anatomical landmarks during laparoscopic cholecystectomy. 61
32306111 2021
48
Effect and related mechanism of Yinchenhao decoction on mice with lithogenic diet-induced cholelithiasis. 61
33717259 2021
49
Eosinophilic cholecystitis in children: Case series. 61
32624207 2021
50
The diagnostic dilemma of a gallbladder volvulus: An unusual case report and review of the literature. 61
33601326 2021

Variations for Cholelithiasis

Expression for Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for Cholelithiasis

Pathways related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 UGT1A8 UGT1A6 UGT1A1 SCARB1 NR1H4 INS
2
Show member pathways
12.43 SCARB1 APOE ALB ABCG8 ABCG5
3
Show member pathways
12.31 SST GAST CCKAR CCK
4 12.29 UGT1A8 UGT1A6 UGT1A1 INS HBB APOE
5
Show member pathways
11.77 SCARB1 HBB APOE ALB
6
Show member pathways
11.77 SCARB1 INS HBB CRP APOE ALB
7
Show member pathways
11.73 SCARB1 CYP7A1 APOE ABCG8 ABCG5
8
Show member pathways
11.64 UGT1A8 UGT1A6 UGT1A1
9
Show member pathways
11.59 UGT1A8 UGT1A6 UGT1A1
10
Show member pathways
11.5 UGT1A8 UGT1A6 UGT1A1 CYP7A1
11
Show member pathways
11.48 UGT1A8 UGT1A6 UGT1A1
12
Show member pathways
11.36 SCARB1 ABCG8 ABCG5
13 11.33 SCARB1 ABCG8 ABCG5
14 11.23 UGT1A8 UGT1A6 UGT1A1 SCARB1 NR1H4 CYP7A1
15
Show member pathways
11.18 UGT1A8 UGT1A6 UGT1A1
16 11 NR1H4 CYP7A1 ABCG5 ABCB4
17 10.89 NR1H4 CYP7A1 ABCB4
18 10.39 GAST CCK

GO Terms for Cholelithiasis

Cellular components related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 SST INS HBB GPT GAST CRP
2 ATP-binding cassette (ABC) transporter complex GO:0043190 8.96 ABCG8 ABCG5

Biological processes related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.92 SCARB1 HBB APOE ALB
2 steroid metabolic process GO:0008202 9.88 UGT1A8 UGT1A1 CYP7A1 APOE
3 response to nutrient GO:0007584 9.83 UGT1A1 SST ABCG8 ABCG5
4 cellular oxidant detoxification GO:0098869 9.81 HBB APOE ALB
5 lipid transport GO:0006869 9.8 SCARB1 APOE ABCG8 ABCG5 ABCB4
6 intermembrane lipid transfer GO:0120009 9.77 APOE ABCG8 ABCG5
7 acute-phase response GO:0006953 9.76 UGT1A1 INS CRP
8 positive regulation of nitric-oxide synthase activity GO:0051000 9.71 SCARB1 INS APOE
9 high-density lipoprotein particle remodeling GO:0034375 9.69 SCARB1 APOE ALB
10 fatty acid homeostasis GO:0055089 9.67 NR1H4 INS APOE
11 cellular glucuronidation GO:0052695 9.65 UGT1A8 UGT1A6 UGT1A1
12 regulation of cholesterol metabolic process GO:0090181 9.64 NR1H4 APOE
13 high-density lipoprotein particle clearance GO:0034384 9.63 SCARB1 APOE
14 intestinal cholesterol absorption GO:0030299 9.63 ABCG8 ABCG5
15 xenobiotic glucuronidation GO:0052697 9.63 UGT1A8 UGT1A6 UGT1A1
16 flavone metabolic process GO:0051552 9.62 UGT1A8 UGT1A1
17 cellular response to bile acid GO:1903413 9.61 NR1H4 ABCB4
18 regulation of bile acid biosynthetic process GO:0070857 9.61 NR1H4 CYP7A1
19 cholesterol catabolic process GO:0006707 9.61 SCARB1 CYP7A1 APOE
20 positive regulation of dendritic spine maintenance GO:1902952 9.59 INS APOE
21 negative regulation of steroid metabolic process GO:0045939 9.57 UGT1A8 UGT1A1
22 negative regulation of intestinal cholesterol absorption GO:0045796 9.56 ABCG8 ABCG5
23 cholesterol efflux GO:0033344 9.56 SCARB1 APOE ABCG8 ABCG5
24 negative regulation of intestinal phytosterol absorption GO:0010949 9.55 ABCG8 ABCG5
25 flavonoid glucuronidation GO:0052696 9.54 UGT1A8 UGT1A6 UGT1A1
26 negative regulation of fatty acid metabolic process GO:0045922 9.5 UGT1A8 UGT1A1 INS
27 bile acid signaling pathway GO:0038183 9.46 NR1H4 CYP7A1 ABCG8 ABCG5
28 cholesterol homeostasis GO:0042632 9.43 SCARB1 NR1H4 CYP7A1 APOE ABCG8 ABCG5
29 triglyceride homeostasis GO:0070328 9.02 SCARB1 NR1H4 APOE ABCG8 ABCG5

Molecular functions related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.77 UGT1A8 UGT1A6 UGT1A1 ABCG8 ABCG5
2 hormone activity GO:0005179 9.62 SST INS GAST CCK
3 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.58 ABCG8 ABCG5 ABCB4
4 glucuronosyltransferase activity GO:0015020 9.43 UGT1A8 UGT1A6 UGT1A1
5 retinoic acid binding GO:0001972 9.33 UGT1A8 UGT1A6 UGT1A1
6 UDP-glycosyltransferase activity GO:0008194 9.13 UGT1A8 UGT1A6 UGT1A1
7 intermembrane cholesterol transfer activity GO:0120020 8.8 APOE ABCG8 ABCG5

Sources for Cholelithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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