MCID: CHL004
MIFTS: 49

Cholelithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholelithiasis

MalaCards integrated aliases for Cholelithiasis:

Name: Cholelithiasis 12 74 29 54 15 17 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10211
ICD9CM 34 574.5
ICD10 32 K80
UMLS 71 C0006739 C0008350

Summaries for Cholelithiasis

MalaCards based summary : Cholelithiasis is related to cholecystolithiasis and cholecystitis. An important gene associated with Cholelithiasis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Glucose / Energy Metabolism. The drugs Dopamine and Esketamine have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and colon, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 74 A gallstone is a stone formed within the gallbladder out of bile components. The term cholelithiasis may... more...

Related Diseases for Cholelithiasis

Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 582)
# Related Disease Score Top Affiliating Genes
1 cholecystolithiasis 32.6 SST GPT CRP CCK
2 cholecystitis 31.8 GPT CCKAR CCK ALB
3 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 31.2 HBB CRP ALB
4 postcholecystectomy syndrome 31.0 GAST CCK
5 ileus 31.0 SST INS CRP CCK
6 intestinal obstruction 30.9 SST GPT CRP ALB
7 biliary dyskinesia 30.9 SST GPT CCK
8 peptic ulcer disease 30.9 SST INS GAST ALB
9 liver cirrhosis 30.9 SST GPT GGT1 ALB
10 duodenal ulcer 30.8 SST INS GAST CCK
11 choledocholithiasis 30.8 UGT1A1 GPT GGT1 CRP ALB ABCB4
12 bile duct cysts 30.7 GPT GGT1 ABCB4
13 obstructive jaundice 30.6 GPT GGT1 CRP ALB
14 sickle cell anemia 30.6 UGT1A8 UGT1A6 UGT1A1 HBB CRP ALB
15 duodenal obstruction 30.5 CRP ALB
16 hepatic encephalopathy 30.5 SST GPT ALB
17 portal hypertension 30.5 SST NR1H4 INS GPT ALB
18 cholestasis, progressive familial intrahepatic, 3 30.5 NR1H4 ABCG8 ABCG5 ABCB4
19 primary hyperparathyroidism 30.4 INS GAST ALB
20 duodenogastric reflux 30.4 SST GAST CCK
21 glucosephosphate dehydrogenase deficiency 30.4 UGT1A8 UGT1A1 HBB
22 gilbert syndrome 30.4 UGT1A8 UGT1A6 UGT1A1 GPT ALB
23 acalculous cholecystitis 30.4 GPT CRP CCKAR CCK ALB
24 cholangitis 30.3 SST NR1H4 GPT GGT1 CRP ALB
25 ascending cholangitis 30.3 GPT CRP ALB
26 pyelonephritis 30.3 GPT CRP ALB
27 suppurative cholangitis 30.3 GPT GGT1 ABCB4
28 familial intrahepatic cholestasis 30.2 NR1H4 GGT1 ABCB4
29 deficiency anemia 30.2 INS HBB GGT1 CRP ALB
30 cholestasis 30.2 NR1H4 GPT GGT1 CYP7A1 CCK ALB
31 carcinoid tumors, intestinal 30.2 SST GAST
32 duodenitis 30.2 INS GAST CRP ALB
33 autonomic neuropathy 30.2 INS GAST CCK ALB
34 acute cystitis 30.2 INS GPT CRP ALB
35 acute cholangitis 30.2 GPT GGT1 CRP ALB
36 cholestasis, intrahepatic, of pregnancy, 1 30.1 NR1H4 GGT1 ABCB4
37 short bowel syndrome 30.1 SST GAST CCK
38 thyroid carcinoma, familial medullary 30.1 SST GAST CCK
39 acute pancreatitis 30.1 SST INS GPT CRP CCKAR CCK
40 diarrhea 30.1 UGT1A1 SST GPT GAST CCK ALB
41 emphysematous cholecystitis 30.1 GPT CRP CCK
42 paralytic ileus 30.1 GPT CRP ALB
43 volvulus of midgut 30.1 GPT CRP ALB
44 bile reflux 30.1 NR1H4 GAST CCK ALB
45 wilson disease 30.0 NR1H4 GPT ALB
46 coronary stenosis 30.0 SCARB1 CRP ALB
47 gallbladder disease 29.9 UGT1A8 UGT1A1 SST NR1H4 INS GPT
48 actinomycosis 29.9 INS CRP ALB
49 nasopharyngitis 29.9 INS GPT CRP
50 fatty liver disease, nonalcoholic 1 29.9 INS GPT GGT1

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to Cholelithiasis

Symptoms & Phenotypes for Cholelithiasis

MGI Mouse Phenotypes related to Cholelithiasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.02 ABCB4 ABCG5 ABCG8 ALB CCKAR CYP7A1
2 homeostasis/metabolism MP:0005376 10 ABCB4 ABCG5 ABCG8 ALB CCK CCKAR
3 endocrine/exocrine gland MP:0005379 9.91 ABCB4 ALB CCK CCKAR GAST GGT1
4 immune system MP:0005387 9.73 ABCB4 ABCG5 ABCG8 ALB CRP CYP7A1
5 liver/biliary system MP:0005370 9.28 ABCB4 ABCG5 ABCG8 ALB CCKAR CYP7A1

Drugs & Therapeutics for Cholelithiasis

Drugs for Cholelithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Esketamine Approved, Investigational Phase 4 33643-46-8
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
5
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
6
tannic acid Approved Phase 4 1401-55-4
7
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
8
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
9
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
10
Temocillin Approved, Investigational Phase 4 66148-78-5
11
Ondansetron Approved Phase 4 99614-02-5 4595
12
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
13
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
14
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
15
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
16
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
17
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
18
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
19
Remifentanil Approved Phase 4 132875-61-7 60815
20
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
21
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
22
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
23
Morphine Approved, Investigational Phase 4 57-27-2 5288826
24
Ephedrine Approved Phase 4 299-42-3 9294
25
Pseudoephedrine Approved Phase 4 90-82-4 7028
26
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
27
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
28
Fosaprepitant Approved Phase 4 172673-20-0 219090
29
Palonosetron Approved, Investigational Phase 4 135729-56-5, 119904-90-4 148211
30
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
31
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
32
Sulbactam Approved Phase 4 68373-14-8
33
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
34
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
35
Sultamicillin Approved, Investigational Phase 4 76497-13-7
36
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
37
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
38
Tauroursodeoxycholic acid Experimental, Investigational Phase 4 14605-22-2 12443252
39 Flurbiprofen axetil Investigational Phase 4 91503-79-6
40 Dopamine Agents Phase 4
41 Excitatory Amino Acid Antagonists Phase 4
42 Dopamine Antagonists Phase 4
43 Antidepressive Agents Phase 4
44 Anesthetics, Dissociative Phase 4
45 Anticonvulsants Phase 4
46 Antiviral Agents Phase 4
47 Anti-Anxiety Agents Phase 4
48 Psychotropic Drugs Phase 4
49 Dermatologic Agents Phase 4
50 Antipsychotic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 204)
# Name Status NCT ID Phase Drugs
1 Randomised Controlled Trail of Warmed Humidified Insufflation Versus Cold Non-Humidified Insufflation in Elective Laparoscopic Cholecystectomies: Does This Reduce Post-Operative Pain? Unknown status NCT00792389 Phase 4
2 DOLCE Study: Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized, Controlled Trial Unknown status NCT01052727 Phase 4
3 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
4 The Discovery of the Double Sphincter in Gallbladder Unknown status NCT01998451 Phase 4 Tauroursodeoxycholic acid
5 The CHOLEGAS Study: Multicentric Randomized, Double-Blinded, Controlled Trial of Gastrectomy Plus Prophylactic Cholecystectomy Versus Gastrectomy Only, in Adults Submitted to Gastric Cancer Surgery With Curative Intent. Unknown status NCT00757640 Phase 4
6 Closed-Loop Target Controlled Infusion of Propofol and Remifentanil Guided by Narcotrend Index in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
7 Laparo-endoscopic Single Site Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT01339325 Phase 4
8 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
9 Temocillin Pharmacokinetics in Paediatrics Unknown status NCT02260102 Phase 4 Temocillin
10 Study of Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy for Uncomplicated Cholelithiasis (Lap vs SILS) Completed NCT01211743 Phase 4
11 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
12 Effects of Intraperitoneal Levobupivacaine on Pain After Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blinded Study Completed NCT00836316 Phase 4 levobupivacaine
13 Effect of Endovenous Lidocaine on Analgesia and Serum Cytokines Concentration: Randomized and Double-blind Trial Completed NCT02363699 Phase 4 Lidocaine;Saline solution
14 Laparoscopic Guided Regional Analgesia (LaGRA) Reduces Post Operative Pain After Laparoscopic Cholecystectomy - a Randomised, Controlled Trial. Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
15 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Completed NCT03168555 Phase 4 chenodeoxycholic acid
16 Combined Preincisional Infiltration and Intraperitoneal Instillation of Levobupivacaine for Postoperative Pain Reduction After Laparoscopic Cholecystectomy; A Double-blind Placebo-controlled Randomised Clinical Trial Completed NCT01199406 Phase 4 Levobupivacaine
17 Granisetron Effect on Hemodynamic Changes and Intubation Condition During Anesthesia Induction in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
18 Robotic Assisted Versus Laparoscopic Cholecystectomy - Completed NCT00562900 Phase 4
19 Cholecystocholangiography Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy: A Prospective Controlled Randomized Trial Completed NCT01103570 Phase 4
20 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy Due to Acute Cholecystitis. Is it Necessary? Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
21 Studie Naar De Effectiviteit Van Ursodeoxycholzuur Ter Preventie Van Galsteen-Gerelateerde Klachten Bij patiënten in Afwachting Van Een Cholecystectomie Completed NCT00161083 Phase 4 ursodeoxycholic acid
22 Dual-Loop Target Controlled Infusion of Propofol and Remifentanil Guided by Narcotrend Index in Laparoscopic Cholecystectomy Completed NCT02116985 Phase 4
23 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy: A Randomized Trial Completed NCT01397565 Phase 4
24 Multi-Port vs. Single-port Cholecystectomy Completed NCT01104727 Phase 4
25 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy: a Randomized Clinical Trial Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
26 COMPARATIVE STUDY BETWEEN PALONOSETRON AND FOSAPREPITANT IN THE PROFILAXIA OF POSTOPERATIVE NAUSEA AND VOMITING IN WOMEN SUBMITTED TO VIDEOLAPAROSCOPIC COLECISTECTOMIES Recruiting NCT03586817 Phase 4 Palonosetron;Fosaprepitant
27 COMPARISON OF INTRAOPERATIVE TRANSVERSUS ABDOMINIS PLANE BLOCK, LOCAL ANESTHESIA APPLICATION TO THE PORT SITES AND INTRAPERITONEAL LOCAL ANESTHETIC APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN LAPAROSCOPIC CHOLECYSTECTOMY PATIENTS Active, not recruiting NCT03790007 Phase 4 Bupivacaine
28 Is an Antibiotic Prescription Required After Laparoscopic Cholecystectomy for Acute Calculous Cholecystitis? Not yet recruiting NCT04290104 Phase 4 1gr oral ampicillin/sulbactam group
29 Ciprofloxacin, Ampicillin-sulbactam and Placebo Prophylaxis in Laparoscopic Cholecystectomy. A Randomized Controlled Study Terminated NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
30 Biliary Lithotripsy in Combination With Actigall Versus Actigall Monotherapy for the Treatment of Symptomatic Cholesterol Gallstones Terminated NCT00042549 Phase 4 ursodiol
31 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
32 Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
33 Thiopurine Induced Pancreatitis in IBD Patients Withdrawn NCT02281799 Phase 4 Azathioprine
34 Single Port Access Cholecystectomy Versus Standard Laparoscopic Cholecystectomy - Randomized Study Unknown status NCT00904865 Phase 2, Phase 3
35 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy: A Prospective Randomized Multicenter Placebo-Controlled Trial Unknown status NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
36 Efficacy and Safety of Renalof Administration in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
37 Prospective Randomized Clinical Trial Comparing Laparoscopic Cholecystectomy and Hybrid Natural Orifice Translumenal Endoscopic Surgery (NOTES) Completed NCT00835250 Phase 3
38 Prospective Randomized Clinical Trial Comparing Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery on Cholecystectomy Completed NCT01558414 Phase 3
39 Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones—a Randomized Controlled Trial Completed NCT00164853 Phase 3
40 An Expertise-based Randomized Controlled Trial Comparing Minilaparotomy Cholecystectomy and Laparoscopic Cholecystectomy Completed NCT00370344 Phase 2, Phase 3
41 A Multicenter, Double-Blind, Placebo-Controlled, Randomized Trial of Efficacy and Safety of Remaxol®, a Solution for Intravenous Infusions Produced by STPF "POLYSAN" (Russia), in Patients With Mechanical Jaundice of Non-Malignant Origin Recruiting NCT03418935 Phase 3 Remaxol (succinate + methionine + inosine + nicotinamide);Ringer's Solution
42 Effect of Two Amino Acid Solutions on Blood Amino Acid Levels and Frequency of Cholestasis in Neonates Terminated NCT01062724 Phase 3
43 Treatment of Suspected Cholelithiasis With Nitroglycerin: a Randomized, Prospective Double-blind Trial Unknown status NCT01715220 Phase 2 sublingual nitroglycerine
44 Transvaginal Natural Orifice Translumenal and Endoscopic Surgery (NOTES) Cholecystectomy vs. Laparoscopic Cholecystectomy: Phase I/II Clinical Trial Completed NCT00710502 Phase 1, Phase 2
45 Effects of Obeticholic Acid on Hepatic Fatty Acid/Triglyceride Metabolism and Hepatobiliary Detoxification/Elimination in Morbidly Obese and Gallstone Patients Completed NCT01625026 Phase 2 Obeticholic acid;Placebo
46 Traitement Des Carcinomes à Cellules de Merkel inopérables et/ou métastatiques Par Analogue de la Somatostatine - Etude Nationale Multicentrique Mono-bras de Phase II. Completed NCT02351128 Phase 2 Lanreotide
47 Natural Orifice Translumenal Endoscopic Surgery: Laparoscopic-Assisted Transvaginal Cholecystectomy Terminated NCT00910325 Phase 1, Phase 2
48 Medical Dissolution of Cholesterol Gallstones Using Oral Aramchol - A Proof of Concept Phase IIa Study Terminated NCT02325492 Phase 2 Aramchol;Placebo
49 Deferasirox Versus Venesection in Patients With Hemochromatosis and for Treatment of Transfusional Siderosis in Myelodysplastic Syndrome: Diagnostics and New Biomarkers. Terminated NCT01892644 Phase 2 Deferasirox;Deferasirox
50 A Phase 1, 2-Part, Randomized, Subject And Investigator Blinded, Placebo-Controlled, Cross-Over Trial To Evaluate The Safety, Tolerability And Pharmacokinetics Of CE-326,597 In Obese, Adult Subjects With Asymptomatic Cholelithiasis Completed NCT00576589 Phase 1 CE-326,597;Placebo

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ursodiol

Genetic Tests for Cholelithiasis

Genetic tests related to Cholelithiasis:

# Genetic test Affiliating Genes
1 Cholelithiasis 29

Anatomical Context for Cholelithiasis

MalaCards organs/tissues related to Cholelithiasis:

40
Liver, Pancreas, Colon, Testes, Heart, Skin, Kidney

Publications for Cholelithiasis

Articles related to Cholelithiasis:

(show top 50) (show all 8029)
# Title Authors PMID Year
1
Cholelithiasis, cholecystectomy, and liver disease. 61 54
20068558 2010
2
The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects. 61 54
20422496 2010
3
Combined features of low phospholipid-associated cholelithiasis and progressive familial intrahepatic cholestasis 3. 54 61
19840255 2010
4
Acute transient hepatocellular injury in cholelithiasis and cholecystitis without evidence of choledocholithiasis. 54 61
19673021 2009
5
ABCB4 sequence variations in young adults with cholesterol gallstone disease. 61 54
19018976 2009
6
Gilbert syndrome as a predisposing factor for cholelithiasis risk in the Greek adult population. 54 61
19309288 2009
7
Association between promoter and coding region mutations of UDP-glucuronosyltransferase 1A1 and beta-thalassemia/Hb E with cholelithiasis. 61 54
18081723 2008
8
[Recurrent intrahepatic cholestasis of pregnancy and chain-like choledocholithiasis in a female patient with stop codon in the ABDC4-gene of the hepatobiliary phospholipid transporter]. 54 61
18188816 2008
9
Early modification of sickle cell disease clinical course by UDP-glucuronosyltransferase 1A1 gene promoter polymorphism. 61 54
18392554 2008
10
The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease. 54 61
17593033 2007
11
MDR3 mutations associated with intrahepatic and gallbladder cholesterol cholelithiasis: an update. 61 54
17786139 2007
12
Reproduction of postprandial symptoms with cholecystokinin injection: an indication for cholecystectomy without the presence of gallstones or an abnormal ejection fraction on quantitative cholescintigraphy? 61 54
17674942 2007
13
[Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease]. 54 61
17438969 2007
14
Acute recurrent biliary pancreatitis associated with the ABCB4 gene mutation. 61 54
17273143 2007
15
UGT1A1 polymorphism outweighs the modest effect of deletional (-3.7 kb) alpha-thalassemia on cholelithogenesis in sickle cell anemia. 61 54
16628735 2006
16
Effects of variant UDP-glucuronosyltransferase 1A1 gene, glucose-6-phosphate dehydrogenase deficiency and thalassemia on cholelithiasis. 61 54
16237771 2005
17
Association of UGT1A1 polymorphism with prevalence and age at onset of cholelithiasis in sickle cell anemia. 61 54
15710570 2005
18
[Low density lipoproteins in patients with cholelithiasis and cholesterosis of the gallbladder]. 54 61
15807442 2005
19
Sincalide in patients with parenteral nutrition-associated gallbladder disease. 54 61
15316105 2004
20
Biliary dyskinesia: a potentially unrecognized cause of abdominal pain in children. 61 54
15322841 2004
21
Gilbert's syndrome as a predisposing factor for idiopathic cholelithiasis in children. 54 61
14555319 2003
22
Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium. 61 54
12801960 2003
23
A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis. 61 54
12671900 2003
24
Influence of bilirubin uridine diphosphate-glucuronosyltransferase 1A promoter polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia. 61 54
11878580 2001
25
MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. 54 61
11313316 2001
26
Cholelithiasis in a newborn following treatment with the somatostatin analogue octreotide. 61 54
10923237 2000
27
[Alpha-L-fucosidase activity in patients with ductal cholelithiasis]. 61 54
9695655 1998
28
Study of the secretion of substance P, neurotensin and somatostatin in patients with cholelithiasis. 61 54
9253232 1997
29
Plasma cholecystokinin levels in acute pancreatitis. 54 61
9094154 1997
30
Different pathways mediate cholecystokinin actions in cholelithiasis. 61 54
9142916 1997
31
Cholelithiasis in Taiwan. Gallstone characteristics, surgical incidence, bile lipid composition, and role of beta-glucuronidase. 54 61
7555451 1995
32
Carcinoembryonic antigen (CEA) and CEA-related substances in the bile of patients with biliary diseases. 61 54
8160902 1994
33
Development and optimization of an enzyme-linked immunosorbent assay employing two murine monoclonal antibodies for absolute quantitation of human beta-glucuronidase. 61 54
1418687 1992
34
A large-scale purification of beta-glucuronidase from human liver by immunoaffinity chromatography. 54 61
1777114 1991
35
Rapid purification of beta-glucuronidase from human liver by immunoaffinity chromatography employing specific murine monoclonal IgG binding to tresyl-activated agarose. 61 54
1821773 1991
36
Carcinoid tumors of the duodenum. A clinicopathologic study of 99 cases. 54 61
1694655 1990
37
[Plasma levels of various gastrointestinal polypeptides in patients with cholelithiasis and different degree of functional disorders of the major duodenal papilla]. 61 54
2278184 1990
38
Comments of manuscript: ultrasound characteristics and outcome of prenatally diagnosed fetal cholelithiasis. 61
30477362 2020
39
Incidence of and risk factors for late cholecystectomy in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. 61
32422507 2020
40
Ceftriaxone-associated biliary pseudolithiasis in children: do we know enough? 61
32492204 2020
41
Effectiveness of near-infrared fluorescent cholangiography in the identification of cystic duct-common hepatic duct anatomy in comparison to magnetic resonance cholangio-pancreatography: a preliminary study. 61
31598878 2020
42
An Important Gallbladder Pathology Mimicking Gallbladder Carcinoma: Xanthogranulomatous Cholecystitis: A Single Tertiary Center Experience. 61
32187090 2020
43
The Clinical Value and Appropriateness Criteria of Upper Abdominal Magnetic Resonance Examinations in Patients Before and After Bariatric Surgery: a Study of 837 Images. 61
32483745 2020
44
Risk factors and characteristics of young patients with the biliary tract carcinoma: results of a project study for biliary surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. 61
32510820 2020
45
A complex case of low-phospholipid-associated cholelithiasis syndrome. 61
32543870 2020
46
Management of symptomatic portal cavernoma cholangiopathy via transplenic portal vein recanalization and TIPS. 61
32500579 2020
47
Cholecystitis on gallbladder duplication: A case report and literature review. 61
32563831 2020
48
Predicting common bile duct stones by non-invasive parameters. 61
31810810 2020
49
MEDICAL TREATMENT LANDSCAPE FOR ACTIVE ACROMEGALY IN A PITUITARY CENTER IN ISRAEL. 61
32576038 2020
50
Analysis of Trajectories of Care After Bariatric Surgery Using Data Mining Method and Health Administrative Information Systems. 61
32030617 2020

Variations for Cholelithiasis

Expression for Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for Cholelithiasis

Pathways related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 UGT1A8 UGT1A6 UGT1A1 SCARB1 NR1H4 INS
2 12.34 UGT1A8 UGT1A6 UGT1A1 INS HBB
3
Show member pathways
11.78 SCARB1 CYP7A1 ABCG8 ABCG5
4
Show member pathways
11.77 SCARB1 INS HBB GGT1 CRP ALB
5
Show member pathways
11.61 UGT1A8 UGT1A6 UGT1A1
6
Show member pathways
11.46 UGT1A8 UGT1A6 UGT1A1
7
Show member pathways
11.38 UGT1A8 UGT1A6 UGT1A1 CYP7A1
8
Show member pathways
11.33 SCARB1 ABCG8 ABCG5
9 11.3 SCARB1 ABCG8 ABCG5
10 11.23 UGT1A8 UGT1A6 UGT1A1 SCARB1 NR1H4 CYP7A1
11
Show member pathways
11.14 UGT1A8 UGT1A6 UGT1A1
12 11 NR1H4 CYP7A1 ABCG5 ABCB4
13 10.82 NR1H4 CYP7A1 ABCB4
14 10.37 GAST CCK

GO Terms for Cholelithiasis

Cellular components related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 SST INS HBB GPT GGT1 GAST
2 ATP-binding cassette (ABC) transporter complex GO:0043190 8.96 ABCG8 ABCG5

Biological processes related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 9.78 SCARB1 ABCG8 ABCG5 ABCB4
2 acute-phase response GO:0006953 9.63 UGT1A1 INS CRP
3 cellular glucuronidation GO:0052695 9.58 UGT1A6 UGT1A1
4 cholesterol catabolic process GO:0006707 9.57 SCARB1 CYP7A1
5 negative regulation of blood vessel diameter GO:0097756 9.56 INS CRP
6 response to nutrient GO:0007584 9.56 UGT1A1 SST ABCG8 ABCG5
7 intestinal cholesterol absorption GO:0030299 9.55 ABCG8 ABCG5
8 flavone metabolic process GO:0051552 9.54 UGT1A8 UGT1A1
9 cellular response to bile acid GO:1903413 9.52 NR1H4 ABCB4
10 regulation of bile acid biosynthetic process GO:0070857 9.51 NR1H4 CYP7A1
11 cholesterol efflux GO:0033344 9.5 SCARB1 ABCG8 ABCG5
12 negative regulation of fatty acid metabolic process GO:0045922 9.49 UGT1A8 INS
13 negative regulation of steroid metabolic process GO:0045939 9.43 UGT1A8 UGT1A1
14 negative regulation of intestinal cholesterol absorption GO:0045796 9.4 ABCG8 ABCG5
15 negative regulation of intestinal phytosterol absorption GO:0010949 9.37 ABCG8 ABCG5
16 xenobiotic glucuronidation GO:0052697 9.33 UGT1A8 UGT1A6 UGT1A1
17 flavonoid glucuronidation GO:0052696 9.13 UGT1A8 UGT1A6 UGT1A1
18 cholesterol homeostasis GO:0042632 9.02 SCARB1 NR1H4 CYP7A1 ABCG8 ABCG5

Molecular functions related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.5 ABCG8 ABCG5 ABCB4
2 hormone activity GO:0005179 9.46 SST INS GAST CCK
3 transferase activity, transferring hexosyl groups GO:0016758 9.43 UGT1A8 UGT1A6 UGT1A1
4 glucuronosyltransferase activity GO:0015020 9.13 UGT1A8 UGT1A6 UGT1A1
5 retinoic acid binding GO:0001972 8.8 UGT1A8 UGT1A6 UGT1A1

Sources for Cholelithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....