MCID: CHL004
MIFTS: 50

Cholelithiasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Cholelithiasis

MalaCards integrated aliases for Cholelithiasis:

Name: Cholelithiasis 12 75 29 55 44 15 17 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:10211
ICD9CM 35 574.5
MeSH 44 D002769
ICD10 33 K80
UMLS 72 C0006739 C0008350

Summaries for Cholelithiasis

MalaCards based summary : Cholelithiasis is related to cholecystolithiasis and gallbladder disease 4. An important gene associated with Cholelithiasis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Dopamine and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and colon, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 75 A gallstone is a stone formed within the gallbladder out of bile components. The term cholelithiasis may... more...

Related Diseases for Cholelithiasis

Diseases related to Cholelithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 435)
# Related Disease Score Top Affiliating Genes
1 cholecystolithiasis 33.1 CCK ABCB4
2 gallbladder disease 4 32.2 ABCG8 ABCG5
3 cholecystitis 31.4 GPT CCK ALB ABCB4
4 cholangitis 31.2 GPT ALB ABCB4
5 choledocholithiasis 31.2 UGT1A1 GPT ALB ABCB4
6 postcholecystectomy syndrome 31.0 SST CCK
7 gallbladder disease 30.9 UGT1A1 CCKAR CCK APOE ABCG8 ABCG5
8 acute pancreatitis 30.7 SST CCKAR CCK
9 cholestasis, progressive familial intrahepatic, 3 30.7 ABCG8 ABCB4
10 portal hypertension 30.6 SST GPT ALB
11 hepatic coma 30.5 GPT ALB
12 liver cirrhosis 30.4 SST GPT ALB
13 liver disease 30.4 NR1H4 GPT ALB ABCB4
14 gilbert syndrome 30.4 UGT1A8 UGT1A6 UGT1A1
15 sclerosing cholangitis 30.4 NR1H4 ALB ABCB4
16 duodenogastric reflux 30.4 SST CCK
17 dyspepsia 30.4 SST CCKAR CCK
18 pancreas disease 30.3 SST CCK ALB
19 esophageal varix 30.3 SST ALB
20 ascending cholangitis 30.3 CCK ALB
21 bilirubin metabolic disorder 30.3 UGT1A6 UGT1A1 GPT ALB
22 cholestasis 30.2 NR1H4 GPT CYP7A1 ABCB4
23 diarrhea 30.1 UGT1A1 SST CCK ALB
24 fascioliasis 29.9 GPT ALB
25 cholangitis, primary sclerosing 29.9 GPT ALB ABCB4
26 aortic atherosclerosis 29.8 APOE ABCG8 ABCG5
27 biliary tract disease 29.6 NR1H4 CYP7A1 CCK ALB ABCB4
28 gastrointestinal system disease 29.5 SST CCKAR CCK ALB
29 body mass index quantitative trait locus 11 29.3 NR1H4 GPT CCKAR CCK APOE
30 bile duct disease 28.2 NR1H4 GPT CYP7A1 CCK ALB ABCB4
31 gallbladder disease 1 12.4
32 clonorchiasis 11.5
33 duodenal atresia 11.5
34 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 11.4
35 spherocytosis, type 1 11.1
36 overhydrated hereditary stomatocytosis 11.1
37 beta-thalassemia, dominant inclusion body type 11.1
38 spherocytosis, type 2 11.1
39 dehydrated hereditary stomatocytosis 2 11.1
40 pancreatitis 10.5
41 familial lcat deficiency 10.5 APOE ALB
42 ileus 10.5
43 sickle cell disease 10.5
44 crigler-najjar syndrome, type i 10.5 UGT1A6 UGT1A1
45 yellow nail syndrome 10.5 SST ALB
46 gallbladder cancer 10.5
47 sickle cell anemia 10.5
48 obstructive jaundice 10.4
49 chylothorax, congenital 10.4 SST ALB
50 hepatic tuberculosis 10.4 GPT ALB

Graphical network of the top 20 diseases related to Cholelithiasis:



Diseases related to Cholelithiasis

Symptoms & Phenotypes for Cholelithiasis

MGI Mouse Phenotypes related to Cholelithiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 ABCB4 ABCG5 ABCG8 ALB APOE CCKAR
2 endocrine/exocrine gland MP:0005379 9.7 ABCB4 ALB APOE CCK CCKAR NR1H4
3 homeostasis/metabolism MP:0005376 9.7 ABCB4 ABCG5 ABCG8 ALB APOE CCK
4 liver/biliary system MP:0005370 9.28 ABCB4 ABCG5 ABCG8 ALB APOE CCKAR

Drugs & Therapeutics for Cholelithiasis

Drugs for Cholelithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 198)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Esketamine Approved, Investigational Phase 4 33643-46-8
5
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
6
tannic acid Approved Phase 4 1401-55-4
7
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
8
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
9
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
10
Ondansetron Approved Phase 4 99614-02-5 4595
11
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
12
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
13
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
14
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
15
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
16
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
17
Remifentanil Approved Phase 4 132875-61-7 60815
18
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
20
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
21
Morphine Approved, Investigational Phase 4 57-27-2 5288826
22
Ephedrine Approved Phase 4 299-42-3 9294
23
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
24
Pseudoephedrine Approved Phase 4 90-82-4 7028
25
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
26
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
27
Fosaprepitant Approved Phase 4 172673-20-0 219090
28
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-61-2, 135729-56-5 148211
29
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
30
Temocillin Approved, Investigational Phase 4 66148-78-5
31
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
32
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
33
Sultamicillin Approved, Investigational Phase 4 76497-13-7
34
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
35
Sulbactam Approved Phase 4 68373-14-8
36
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
37
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
38
Taurochenodeoxycholic acid Experimental Phase 4 516-35-8 387316
39
Tauroursodeoxycholic acid Experimental, Investigational Phase 4 14605-22-2 12443252
40 Flurbiprofen axetil Investigational Phase 4 91503-79-6
41 Excitatory Amino Acid Antagonists Phase 4
42 Anesthetics, Dissociative Phase 4
43 Dopamine Agents Phase 4
44 Excitatory Amino Acids Phase 4
45 Anticonvulsants Phase 4
46 Dopamine Antagonists Phase 4
47 Antimanic Agents Phase 4
48 Dopamine D2 Receptor Antagonists Phase 4
49 Antidepressive Agents Phase 4
50 Antiviral Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 188)
# Name Status NCT ID Phase Drugs
1 Randomised Controlled Trail of Warmed Humidified Insufflation Versus Cold Non-Humidified Insufflation in Elective Laparoscopic Cholecystectomies: Does This Reduce Post-Operative Pain? Unknown status NCT00792389 Phase 4
2 DOLCE Study: Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized, Controlled Trial Unknown status NCT01052727 Phase 4
3 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
4 The Discovery of the Double Sphincter in Gallbladder Unknown status NCT01998451 Phase 4 Tauroursodeoxycholic acid
5 The CHOLEGAS Study: Multicentric Randomized, Double-Blinded, Controlled Trial of Gastrectomy Plus Prophylactic Cholecystectomy Versus Gastrectomy Only, in Adults Submitted to Gastric Cancer Surgery With Curative Intent. Unknown status NCT00757640 Phase 4
6 Closed-Loop Target Controlled Infusion of Propofol and Remifentanil Guided by Narcotrend Index in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
7 Laparo-endoscopic Single Site Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT01339325 Phase 4
8 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
9 Study of Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy for Uncomplicated Cholelithiasis (Lap vs SILS) Completed NCT01211743 Phase 4
10 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
11 Effects of Intraperitoneal Levobupivacaine on Pain After Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blinded Study Completed NCT00836316 Phase 4 levobupivacaine
12 Effect of Endovenous Lidocaine on Analgesia and Serum Cytokines Concentration: Randomized and Double-blind Trial Completed NCT02363699 Phase 4 Lidocaine;Saline solution
13 Combined Preincisional Infiltration and Intraperitoneal Instillation of Levobupivacaine for Postoperative Pain Reduction After Laparoscopic Cholecystectomy; A Double-blind Placebo-controlled Randomised Clinical Trial Completed NCT01199406 Phase 4 Levobupivacaine
14 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Completed NCT03168555 Phase 4 chenodeoxycholic acid
15 Laparoscopic Guided Regional Analgesia (LaGRA) Reduces Post Operative Pain After Laparoscopic Cholecystectomy - a Randomised, Controlled Trial. Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
16 Granisetron Effect on Hemodynamic Changes and Intubation Condition During Anesthesia Induction in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
17 Robotic Assisted Versus Laparoscopic Cholecystectomy - Completed NCT00562900 Phase 4
18 Balloon Catheter Versus Basket Catheter for Endoscopic Bile Duct Stone Extraction in Patients With Periampullary Diverticulum:a Multicenter Randomized Trial Completed NCT02909595 Phase 4
19 Cholecystocholangiography Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy: A Prospective Controlled Randomized Trial Completed NCT01103570 Phase 4
20 Dual-Loop Target Controlled Infusion of Propofol and Remifentanil Guided by Narcotrend Index in Laparoscopic Cholecystectomy Completed NCT02116985 Phase 4
21 Studie Naar De Effectiviteit Van Ursodeoxycholzuur Ter Preventie Van Galsteen-Gerelateerde Klachten Bij patiënten in Afwachting Van Een Cholecystectomie Completed NCT00161083 Phase 4 ursodeoxycholic acid
22 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy Due to Acute Cholecystitis. Is it Necessary? Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
23 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy: A Randomized Trial Completed NCT01397565 Phase 4
24 Multi-Port vs. Single-port Cholecystectomy Completed NCT01104727 Phase 4
25 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy: a Randomized Clinical Trial Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
26 COMPARATIVE STUDY BETWEEN PALONOSETRON AND FOSAPREPITANT IN THE PROFILAXIA OF POSTOPERATIVE NAUSEA AND VOMITING IN WOMEN SUBMITTED TO VIDEOLAPAROSCOPIC COLECISTECTOMIES Recruiting NCT03586817 Phase 4 Palonosetron;Fosaprepitant
27 Temocillin Pharmacokinetics in Paediatrics Recruiting NCT02260102 Phase 4 Temocillin
28 COMPARISON OF INTRAOPERATIVE TRANSVERSUS ABDOMINIS PLANE BLOCK, LOCAL ANESTHESIA APPLICATION TO THE PORT SITES AND INTRAPERITONEAL LOCAL ANESTHETIC APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN LAPAROSCOPIC CHOLECYSTECTOMY PATIENTS Active, not recruiting NCT03790007 Phase 4 Bupivacaine
29 Ciprofloxacin, Ampicillin-sulbactam and Placebo Prophylaxis in Laparoscopic Cholecystectomy. A Randomized Controlled Study Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
30 Biliary Lithotripsy in Combination With Actigall Versus Actigall Monotherapy for the Treatment of Symptomatic Cholesterol Gallstones Terminated NCT00042549 Phase 4 ursodiol
31 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
32 Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
33 Thiopurine Induced Pancreatitis in IBD Patients Withdrawn NCT02281799 Phase 4 Azathioprine
34 Single Port Access Cholecystectomy Versus Standard Laparoscopic Cholecystectomy - Randomized Study Unknown status NCT00904865 Phase 2, Phase 3
35 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy: A Prospective Randomized Multicenter Placebo-Controlled Trial Unknown status NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
36 Efficacy and Safety of Renalof Administration in the Treatment of Elderly Patients With Gallstones Completed NCT01099319 Phase 3
37 Prospective Randomized Clinical Trial Comparing Laparoscopic Cholecystectomy and Hybrid Natural Orifice Translumenal Endoscopic Surgery (NOTES) Completed NCT00835250 Phase 3
38 Prospective Randomized Clinical Trial Comparing Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery on Cholecystectomy Completed NCT01558414 Phase 3
39 Combined Sphincterotomy and Balloon Dilation (ESBD) Versus Standard Sphincterotomy (ES) in Removing Biliary Stones—a Randomized Controlled Trial Completed NCT00164853 Phase 3
40 Digital SpyGlass Cholangioscopy Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
41 An Expertise-based Randomized Controlled Trial Comparing Minilaparotomy Cholecystectomy and Laparoscopic Cholecystectomy Completed NCT00370344 Phase 2, Phase 3
42 A Multicenter, Double-Blind, Placebo-Controlled, Randomized Trial of Efficacy and Safety of Remaxol®, a Solution for Intravenous Infusions Produced by STPF "POLYSAN" (Russia), in Patients With Mechanical Jaundice of Non-Malignant Origin Recruiting NCT03418935 Phase 3 Remaxol (succinate + methionine + inosine + nicotinamide);Ringer's Solution
43 Effect of Two Amino Acid Solutions on Blood Amino Acid Levels and Frequency of Cholestasis in Neonates Terminated NCT01062724 Phase 3
44 Transvaginal Natural Orifice Translumenal and Endoscopic Surgery (NOTES) Cholecystectomy vs. Laparoscopic Cholecystectomy: Phase I/II Clinical Trial Completed NCT00710502 Phase 1, Phase 2
45 Effects of Obeticholic Acid on Hepatic Fatty Acid/Triglyceride Metabolism and Hepatobiliary Detoxification/Elimination in Morbidly Obese and Gallstone Patients Completed NCT01625026 Phase 2 Obeticholic acid;Placebo
46 Traitement Des Carcinomes à Cellules de Merkel inopérables et/ou métastatiques Par Analogue de la Somatostatine - Etude Nationale Multicentrique Mono-bras de Phase II. Completed NCT02351128 Phase 2 Lanreotide
47 Treatment of Suspected Cholelithiasis With Nitroglycerin: a Randomized, Prospective Double-blind Trial Recruiting NCT01715220 Phase 2 sublingual nitroglycerine
48 Natural Orifice Translumenal Endoscopic Surgery: Laparoscopic-Assisted Transvaginal Cholecystectomy Terminated NCT00910325 Phase 1, Phase 2
49 Medical Dissolution of Cholesterol Gallstones Using Oral Aramchol - A Proof of Concept Phase IIa Study Terminated NCT02325492 Phase 2 Aramchol;Placebo
50 Deferasirox Versus Venesection in Patients With Hemochromatosis and for Treatment of Transfusional Siderosis in Myelodysplastic Syndrome: Diagnostics and New Biomarkers. Terminated NCT01892644 Phase 2 Deferasirox;Deferasirox

Search NIH Clinical Center for Cholelithiasis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Ox bile extract
Ursodeoxycholic acid
Ursodiol

Cochrane evidence based reviews: cholelithiasis

Genetic Tests for Cholelithiasis

Genetic tests related to Cholelithiasis:

# Genetic test Affiliating Genes
1 Cholelithiasis 29

Anatomical Context for Cholelithiasis

MalaCards organs/tissues related to Cholelithiasis:

41
Liver, Pancreas, Colon, Testes, Heart, Skin, Kidney

Publications for Cholelithiasis

Articles related to Cholelithiasis:

(show top 50) (show all 7872)
# Title Authors PMID Year
1
Cholelithiasis, cholecystectomy, and liver disease. 9 38
20068558 2010
2
The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects. 9 38
20422496 2010
3
Combined features of low phospholipid-associated cholelithiasis and progressive familial intrahepatic cholestasis 3. 9 38
19840255 2010
4
Acute transient hepatocellular injury in cholelithiasis and cholecystitis without evidence of choledocholithiasis. 9 38
19673021 2009
5
ABCB4 sequence variations in young adults with cholesterol gallstone disease. 9 38
19018976 2009
6
Gilbert syndrome as a predisposing factor for cholelithiasis risk in the Greek adult population. 9 38
19309288 2009
7
Association between promoter and coding region mutations of UDP-glucuronosyltransferase 1A1 and beta-thalassemia/Hb E with cholelithiasis. 9 38
18081723 2008
8
Early modification of sickle cell disease clinical course by UDP-glucuronosyltransferase 1A1 gene promoter polymorphism. 9 38
18392554 2008
9
[Recurrent intrahepatic cholestasis of pregnancy and chain-like choledocholithiasis in a female patient with stop codon in the ABDC4-gene of the hepatobiliary phospholipid transporter]. 9 38
18188816 2008
10
MDR3 mutations associated with intrahepatic and gallbladder cholesterol cholelithiasis: an update. 9 38
17786139 2007
11
Reproduction of postprandial symptoms with cholecystokinin injection: an indication for cholecystectomy without the presence of gallstones or an abnormal ejection fraction on quantitative cholescintigraphy? 9 38
17674942 2007
12
The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease. 9 38
17593033 2007
13
[Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease]. 9 38
17438969 2007
14
Acute recurrent biliary pancreatitis associated with the ABCB4 gene mutation. 9 38
17273143 2007
15
UGT1A1 polymorphism outweighs the modest effect of deletional (-3.7 kb) alpha-thalassemia on cholelithogenesis in sickle cell anemia. 9 38
16628735 2006
16
Effects of variant UDP-glucuronosyltransferase 1A1 gene, glucose-6-phosphate dehydrogenase deficiency and thalassemia on cholelithiasis. 9 38
16237771 2005
17
Association of UGT1A1 polymorphism with prevalence and age at onset of cholelithiasis in sickle cell anemia. 9 38
15710570 2005
18
[Low density lipoproteins in patients with cholelithiasis and cholesterosis of the gallbladder]. 9 38
15807442 2005
19
Sincalide in patients with parenteral nutrition-associated gallbladder disease. 9 38
15316105 2004
20
Biliary dyskinesia: a potentially unrecognized cause of abdominal pain in children. 9 38
15322841 2004
21
Gilbert's syndrome as a predisposing factor for idiopathic cholelithiasis in children. 9 38
14555319 2003
22
Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium. 9 38
12801960 2003
23
A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis. 9 38
12671900 2003
24
Influence of bilirubin uridine diphosphate-glucuronosyltransferase 1A promoter polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia. 9 38
11878580 2001
25
MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. 9 38
11313316 2001
26
Cholelithiasis in a newborn following treatment with the somatostatin analogue octreotide. 9 38
10923237 2000
27
[Alpha-L-fucosidase activity in patients with ductal cholelithiasis]. 9 38
9695655 1998
28
Study of the secretion of substance P, neurotensin and somatostatin in patients with cholelithiasis. 9 38
9253232 1997
29
Different pathways mediate cholecystokinin actions in cholelithiasis. 9 38
9142916 1997
30
Plasma cholecystokinin levels in acute pancreatitis. 9 38
9094154 1997
31
Cholelithiasis in Taiwan. Gallstone characteristics, surgical incidence, bile lipid composition, and role of beta-glucuronidase. 9 38
7555451 1995
32
Carcinoembryonic antigen (CEA) and CEA-related substances in the bile of patients with biliary diseases. 9 38
8160902 1994
33
Development and optimization of an enzyme-linked immunosorbent assay employing two murine monoclonal antibodies for absolute quantitation of human beta-glucuronidase. 9 38
1418687 1992
34
A large-scale purification of beta-glucuronidase from human liver by immunoaffinity chromatography. 9 38
1777114 1991
35
Rapid purification of beta-glucuronidase from human liver by immunoaffinity chromatography employing specific murine monoclonal IgG binding to tresyl-activated agarose. 9 38
1821773 1991
36
Carcinoid tumors of the duodenum. A clinicopathologic study of 99 cases. 9 38
1694655 1990
37
[Plasma levels of various gastrointestinal polypeptides in patients with cholelithiasis and different degree of functional disorders of the major duodenal papilla]. 9 38
2278184 1990
38
Laparoscopic Adrenalectomy Has the Same Operative Risk as Routine Laparoscopic Cholecystectomy. 38
31029933 2019
39
A novel gallbladder umbrella stent (the Shai™ Stent) for prevention of stone migration and impaction: results on feasibility and short-term safety in a porcine model. 38
31321534 2019
40
Cytomorphology of intraductal papillary neoplasm of the biliary tract. 38
31116517 2019
41
Neonatal Jaundice. 38
30790186 2019
42
Correction to: Incidence and Risk Factors for Cholelithiasis After Bariatric Surgery. 38
31140164 2019
43
Effectiveness of Ursodeoxycholic Acid in the Prevention of Cholelithiasis After Sleeve Gastrectomy. 38
30945151 2019
44
The impact of dementia on surgical outcomes of laparoscopic cholecystectomy for symptomatic cholelithiasis and acute cholecystitis: A retrospective study. 38
31389183 2019
45
Cholelithiasis and choledocholithiasis in a 78-day-old infant suffering from jaundice, and treated through laparoscopic transcystic common bile duct exploration (LTCBDE). 38
31383571 2019
46
Neutrophil Extracellular Traps Initiate Gallstone Formation. 38
31422870 2019
47
The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set. 38
31016355 2019
48
A homozygous ABCB4 mutation causing an LPAC syndrome evolves into cholangiocarcinoma. 38
31181191 2019
49
Subserosal Leiomyoma with Intravenous Leiomyomatosis Extending into Inferior Vena Cava and Right-sided Cardiac Chambers. 38
31358103 2019
50
Intrahepatic cholestasis of pregnancy and comorbidity: A 44-year follow-up study. 38
31355915 2019

Variations for Cholelithiasis

Expression for Cholelithiasis

Search GEO for disease gene expression data for Cholelithiasis.

Pathways for Cholelithiasis

Pathways related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 UGT1A8 UGT1A6 UGT1A1 SCARB1 NR1H4 GPT
2
Show member pathways
12.37 SCARB1 APOE ALB ABCG8 ABCG5
3 12.3 UGT1A8 UGT1A6 UGT1A1 APOE
4
Show member pathways
11.97 NR1H4 CYP7A1 ALB
5
Show member pathways
11.72 SCARB1 APOE ALB
6
Show member pathways
11.63 SCARB1 CYP7A1 APOE ABCG8 ABCG5
7
Show member pathways
11.57 UGT1A8 UGT1A6 UGT1A1
8
Show member pathways
11.38 UGT1A8 UGT1A6 UGT1A1 CYP7A1
9 11.3 SCARB1 ABCG8 ABCG5
10
Show member pathways
11.28 SCARB1 ABCG8 ABCG5
11
Show member pathways
11.11 UGT1A8 UGT1A6 UGT1A1
12 11.06 UGT1A6 UGT1A1
13 10.96 SCARB1 NR1H4 CYP7A1 ABCG8 ABCG5 ABCB4
14 10.82 NR1H4 CYP7A1 ABCB4
15 10.8 NR1H4 CYP7A1 ABCG5 ABCB4
16 10.77 NR1H4 CYP7A1

GO Terms for Cholelithiasis

Cellular components related to Cholelithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.73 UGT1A8 UGT1A6 UGT1A1 CYP7A1 APOE ALB
2 integral component of plasma membrane GO:0005887 9.63 UGT1A1 SCARB1 CCKAR ABCG8 ABCG5 ABCB4
3 intracellular membrane-bounded organelle GO:0043231 9.35 UGT1A8 UGT1A6 UGT1A1 SCARB1 CYP7A1
4 ATP-binding cassette (ABC) transporter complex GO:0043190 8.62 ABCG8 ABCG5

Biological processes related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.83 UGT1A1 SST ABCG8 ABCG5
2 steroid metabolic process GO:0008202 9.76 UGT1A8 UGT1A1 CYP7A1 APOE
3 response to nutrient GO:0007584 9.73 UGT1A1 SST ABCG8 ABCG5
4 lipid homeostasis GO:0055088 9.72 NR1H4 APOE ABCB4
5 triglyceride homeostasis GO:0070328 9.71 SCARB1 NR1H4 APOE
6 digestion GO:0007586 9.63 SST CCK
7 response to steroid hormone GO:0048545 9.63 UGT1A1 SST
8 positive regulation of nitric-oxide synthase activity GO:0051000 9.62 SCARB1 APOE
9 reverse cholesterol transport GO:0043691 9.62 SCARB1 APOE
10 fatty acid homeostasis GO:0055089 9.61 NR1H4 APOE
11 retinoic acid metabolic process GO:0042573 9.61 UGT1A8 UGT1A1
12 cellular glucuronidation GO:0052695 9.6 UGT1A6 UGT1A1
13 regulation of cholesterol metabolic process GO:0090181 9.59 NR1H4 APOE
14 intestinal cholesterol absorption GO:0030299 9.58 ABCG8 ABCG5
15 high-density lipoprotein particle clearance GO:0034384 9.58 SCARB1 APOE
16 high-density lipoprotein particle remodeling GO:0034375 9.58 SCARB1 APOE ALB
17 flavone metabolic process GO:0051552 9.57 UGT1A8 UGT1A1
18 regulation of bile acid biosynthetic process GO:0070857 9.56 NR1H4 CYP7A1
19 lipid transport GO:0006869 9.55 SCARB1 APOE ABCG8 ABCG5 ABCB4
20 cholesterol catabolic process GO:0006707 9.54 SCARB1 CYP7A1 APOE
21 negative regulation of steroid metabolic process GO:0045939 9.51 UGT1A8 UGT1A1
22 xenobiotic glucuronidation GO:0052697 9.5 UGT1A8 UGT1A6 UGT1A1
23 negative regulation of intestinal phytosterol absorption GO:0010949 9.49 ABCG8 ABCG5
24 negative regulation of intestinal cholesterol absorption GO:0045796 9.48 ABCG8 ABCG5
25 flavonoid glucuronidation GO:0052696 9.43 UGT1A8 UGT1A6 UGT1A1
26 cholesterol efflux GO:0033344 9.26 SCARB1 APOE ABCG8 ABCG5
27 cholesterol homeostasis GO:0042632 9.1 SCARB1 NR1H4 CYP7A1 APOE ABCG8 ABCG5

Molecular functions related to Cholelithiasis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.83 UGT1A8 UGT1A6 UGT1A1 SCARB1 APOE
2 protein heterodimerization activity GO:0046982 9.8 UGT1A8 UGT1A6 UGT1A1 ABCG8 ABCG5
3 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.54 ABCG8 ABCG5 ABCB4
4 transferase activity, transferring hexosyl groups GO:0016758 9.5 UGT1A8 UGT1A6 UGT1A1
5 steroid binding GO:0005496 9.49 UGT1A8 UGT1A1
6 fatty acid binding GO:0005504 9.48 UGT1A8 ALB
7 antioxidant activity GO:0016209 9.46 APOE ALB
8 glucuronosyltransferase activity GO:0015020 9.43 UGT1A8 UGT1A6 UGT1A1
9 retinoic acid binding GO:0001972 9.33 UGT1A8 UGT1A6 UGT1A1
10 UDP-glycosyltransferase activity GO:0008194 9.13 UGT1A8 UGT1A6 UGT1A1
11 cholesterol transporter activity GO:0017127 8.8 APOE ABCG8 ABCG5

Sources for Cholelithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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