MCID: CHL068
MIFTS: 60

Cholestasis

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Cholestasis

MalaCards integrated aliases for Cholestasis:

Name: Cholestasis 12 77 30 56 6 45 15 74
Obstruction of Bile Duct 12
Bile Duct Obstruction 56
Bile Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13580
ICD9CM 36 576.2
MeSH 45 D002779
NCIt 51 C83006
SNOMED-CT 69 30144000 33688009
ICD10 34 K83.1
UMLS 74 C0008370

Summaries for Cholestasis

MalaCards based summary : Cholestasis, also known as obstruction of bile duct, is related to cholestasis, progressive familial intrahepatic, 3 and cholestasis, progressive familial intrahepatic, 2, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Cholestasis is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways/superpathways are Metabolism and Synthesis of bile acids and bile salts. The drugs Ursodeoxycholic acid and chenodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related phenotypes are no effect and growth/size/body region

Wikipedia : 77 Cholestasis is a condition where bile cannot flow from the liver to the duodenum. The two basic... more...

Related Diseases for Cholestasis

Diseases related to Cholestasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 410)
# Related Disease Score Top Affiliating Genes
1 cholestasis, progressive familial intrahepatic, 3 34.3 ABCB11 ABCB4 ATP8B1 JAG1
2 cholestasis, progressive familial intrahepatic, 2 34.3 ABCB11 ABCB4 ATP8B1 NR1H4
3 arthrogryposis, renal dysfunction, and cholestasis 1 34.3 VIPAS39 VPS33B
4 cholestasis, progressive familial intrahepatic, 1 34.3 ABCB11 ABCB4 ATP8B1 JAG1 NR1H4
5 cholestasis, benign recurrent intrahepatic, 1 34.1 ABCB11 ATP8B1 SLC10A1
6 cholestasis, progressive familial intrahepatic, 4 34.1 ABCB11 ABCB4 ATP8B1 TJP2
7 cholestasis, progressive familial intrahepatic, 5 34.1 NR1H4 NR1I2 NR1I3
8 cholestasis, benign recurrent intrahepatic, 2 34.0 ABCB11 ATP8B1
9 progressive familial intrahepatic cholestasis 33.9 ABCB11 ABCB4 ABCC2 ATP8B1 NR1H4 TJP2
10 alagille syndrome 1 33.4 ABCB11 ABCB4 ATP8B1 JAG1
11 extrahepatic cholestasis 32.9 ABCB4 ABCC2 ABCC3 CYP7A1 GGT1 GPT
12 atp8b1 deficiency 32.6 ABCB11 ATP8B1 NR1H4
13 intrahepatic cholestasis of pregnancy 32.4 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 GGT1
14 biliary atresia, extrahepatic 31.8 GGT1 JAG1
15 biliary atresia 31.8 ATP8B1 GPT JAG1 NR1H4 SLC10A1
16 cholangitis 30.8 ABCB11 ABCB4 GGT1 GPT
17 sclerosing cholangitis 30.5 ABCB11 ABCB4 GGT1 NR1H4 NR1I2
18 bilirubin metabolic disorder 30.4 ABCC2 GGT1 GPT NR1I3
19 cholangitis, primary sclerosing 30.3 ABCB4 GGT1 GPT NR1I2
20 dubin-johnson syndrome 30.2 ABCC2 ABCC3 ABCC4
21 cholelithiasis 30.2 ABCB4 CYP7A1 GPT NR1H4
22 choledocholithiasis 30.2 ABCB4 ALPP GPT
23 liver disease 30.1 ABCB11 ABCB4 ALPP ATP8B1 GGT1 GPT
24 obstructive jaundice 30.1 ALPP GGT1 GPT SLC25A13
25 cerebrotendinous xanthomatosis 29.5 CYP7A1 NR1H4 NR1I2
26 cholestasis, intrahepatic, of pregnancy, 1 12.6
27 cholestasis, intrahepatic, of pregnancy 3 12.6
28 cholestasis-lymphedema syndrome 12.5
29 arthrogryposis, renal dysfunction, and cholestasis 2 12.5
30 citrullinemia, type ii, neonatal-onset 12.2
31 bile acid synthesis defect, congenital, 1 12.1
32 cholestasis with gallstone, ataxia, and visual disturbance 12.0
33 myo5b-related progressive familial intrahepatic cholestasis 12.0
34 bile acid synthesis defect, congenital, 2 11.9
35 gracile syndrome 11.9
36 bile acid synthesis defect, congenital, 4 11.8
37 alagille syndrome 2 11.6
38 hyperbiliverdinemia 11.5
39 gallbladder disease 1 11.5
40 hardikar syndrome 11.5
41 citrullinemia, type ii, adult-onset 11.3
42 primary biliary cholangitis 11.3
43 primary biliary cirrhosis 11.3
44 pancreas, dorsal, agenesis of 11.3
45 gilbert syndrome 11.2
46 niemann-pick disease, type c1 11.2
47 crigler-najjar syndrome, type ii 11.2
48 bile acid synthesis defect, congenital, 3 11.1
49 sclerosing cholangitis, neonatal 11.1
50 congenital bile acid synthesis defect 11.0

Comorbidity relations with Cholestasis via Phenotypic Disease Network (PDN): (show all 16)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Cholangitis
Cholecystitis Deficiency Anemia
Duodenum Cancer Esophagitis
Gallbladder Cancer Gastrointestinal System Cancer
Intrahepatic Gall Duct Cancer Pancreatic Agenesis 1
Pancreatic Cancer Pancreatitis, Hereditary
Paralytic Ileus Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Cholestasis:



Diseases related to Cholestasis

Symptoms & Phenotypes for Cholestasis

UMLS symptoms related to Cholestasis:


icterus, jaundice (not of newborn)

GenomeRNAi Phenotypes related to Cholestasis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALPP

MGI Mouse Phenotypes related to Cholestasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ABCB11 ABCB4 ABCC4 ATP8B1 CYP7A1 GGT1
2 homeostasis/metabolism MP:0005376 10.13 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
3 integument MP:0010771 9.81 ABCC3 ABCC4 CYP7A1 GGT1 HSD3B7 JAG1
4 liver/biliary system MP:0005370 9.73 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 CYP7A1
5 mortality/aging MP:0010768 9.44 ABCB11 ABCC4 ATP8B1 CYP7A1 GGT1 HSD3B7

Drugs & Therapeutics for Cholestasis

Drugs for Cholestasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 321)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 128-13-2 31401
2
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1 474-25-9 10133
3
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Not Applicable 616-91-1 12035
4
Abatacept Approved Phase 4 332348-12-6 10237
5 Coconut Approved Phase 4,Not Applicable
6
Glycerol Approved, Investigational Phase 4 56-81-5 753
7
Sorbitol Approved Phase 4 50-70-4 5780
8
Tocopherol Approved, Investigational Phase 4,Phase 3 1406-66-2 14986
9
Methionine Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 63-68-3 6137
10
Choline Approved, Nutraceutical Phase 4 62-49-7 305
11
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-02-9 14985
12 Tocotrienol Investigational Phase 4,Phase 3 6829-55-6
13 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Antimetabolites Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
15 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
16 Nootropic Agents Phase 4
17 Polyene phosphatidylcholine Phase 4
18 Lipid Regulating Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
19 Lecithin Phase 4
20 Hypolipidemic Agents Phase 4,Phase 3,Phase 1,Phase 2
21 Fat Emulsions, Intravenous Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Soybean oil, phospholipid emulsion Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
23 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Soy Bean Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Parenteral Nutrition Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Bile Acids and Salts Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
27 Olive Phase 4,Phase 3,Phase 1,Phase 2
28 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Cholagogues and Choleretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Omega 3 Fatty Acid Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Cathartics Phase 4,Phase 3,Phase 2,Early Phase 1
33 Laxatives Phase 4,Phase 3,Phase 2,Early Phase 1
34 Vitamins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
35 Ulipristal acetate Phase 4 126784-99-4
36 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 N-monoacetylcystine Phase 4,Phase 2,Not Applicable
38 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Free Radical Scavengers Phase 4,Phase 3,Phase 2,Not Applicable
40 Antidotes Phase 4,Phase 2,Not Applicable
41 Expectorants Phase 4,Phase 2,Not Applicable
42 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Not Applicable
44 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Phytosterol Phase 4
47 Tocopherols Phase 4,Phase 3
48 Tocotrienols Phase 4,Phase 3
49
Fenofibrate Approved Phase 3,Phase 1,Phase 2 49562-28-9 3339
50
Bezafibrate Approved, Investigational Phase 3 41859-67-0 39042

Interventional clinical trials:

(show top 50) (show all 392)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis Unknown status NCT01998620 Phase 4 Ademetionine 2;Ademetionine 1;Ademetionine 3
2 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
3 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
4 Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion Unknown status NCT01786759 Phase 4 ClinOleic;Intralipid
5 Preventing Cholestasis Using SMOFLipid® Completed NCT01585935 Phase 4 SMOFLIPID;INTRALIPID
6 The Preventative and Therapeutical Effect of Ursodeoxycholic Acid(UDCA) to Short Bowel Syndrome Patients Completed NCT01974336 Phase 4 ursodeoxycholic acid
7 Pilot Study: Hepatoprotective Role of SMOFlipid® Used in Short-term Parenteral Nutrition in an Onco-Hematology Pediatric Population Completed NCT02539316 Phase 4 Smoflipid;Médialipides
8 RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction Completed NCT00980889 Phase 4
9 The Usefulness of Endoscopic Ultrasound-guided Biliary Drainage With a Newly Designed Hybrid Metallic Stent Completed NCT01862198 Phase 4
10 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
11 Antegrade Arterial and Portal Flushing Versus Portal Flushing Only in LDLT Completed NCT03048318 Phase 4
12 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
13 Comparing Covered Self-expandable Metallic Stent (SEMS) Above/Across the Sphincter of Oddi Completed NCT01041612 Phase 4
14 N-acetylcysteine to Reduce Ischemia/Reperfusion Injury in Liver Resection Completed NCT01223326 Phase 4 Acetylcysteine (NAC);Saline
15 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
16 Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis Completed NCT02078882 Phase 4
17 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4 UDCA (Ursodeoxycholic acid);UDCA (Ursodeoxycholic acid)
18 Evaluation of Glycerin Suppositories to Improve Bowel Function in Gastroschisis Recruiting NCT03355326 Phase 4 Glycerin Suppository
19 Use of Omega-3 Fat Emulsion (Omegaven) in Infants With Parenteral Nutrition Associated Liver Disease Recruiting NCT00862446 Phase 4 Omegaven
20 Study of OCA Evaluating Pharmacokinetics and Safety in Patients With PBC and Hepatic Impairment Recruiting NCT03633227 Phase 4 Obeticholic Acid (OCA);Placebo
21 A Trial of 18-22mg/kg/d Ursodeoxycholic in Refractory Primary Biliary Cholangitis Recruiting NCT03345589 Phase 4 18-22mg/kg/d Ursodeoxycholic;13-15mg/kg/d Ursodeoxycholic
22 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
23 WallFlex Biliary Fully Covered (FC) Chronic Pancreatitis Study Active, not recruiting NCT01543256 Phase 4
24 Personalized vs Standardized PN for Preterm Infants >1250g Not yet recruiting NCT03693287 Phase 4 Standardized-parenteral nutrition (S-PN);Personalized-parenteral nutrition (P-PN)
25 Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid Emulsions Terminated NCT02633384 Phase 4
26 Low Dose Fat for the Prevention of Liver Disease in Babies With Gastrointestinal Disorders Terminated NCT01373918 Phase 4 Intralipid;Intralipid
27 Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion Terminated NCT02476994 Phase 4 Clinolipid;Intralipid
28 SMOFLipid in Patients Who Are Intralipid Intolerant Withdrawn NCT03054948 Phase 4 SMOFLipid;Standard therapy
29 Minimization of IntraLipid Versus Omegaven Unknown status NCT01247012 Phase 2, Phase 3
30 Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid Unknown status NCT02823366 Phase 3 Fenofibrate;UDCA
31 Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Unknown status NCT02823353 Phase 3 Fenofibrate;UDCA
32 The Effect of Bezafibrate on Cholestatic Itch Unknown status NCT02701166 Phase 3 Bezafibrate;Placebo
33 WallFlex Biliary Fully Covered (FC) Benign Stricture Study Unknown status NCT01014390 Phase 3
34 Photodynamic Therapy (PDT) for Palliation of Cholangiocarcinoma Unknown status NCT01755013 Phase 2, Phase 3
35 Fuzhenghuayu for Patients With PBC Who Had An Inadequate Response to Ursodeoxycholic Acid Unknown status NCT02916641 Phase 3 Fuzhenghuayu;UDCA
36 Fuzhenghuayu in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Unknown status NCT02916290 Phase 3 Fuzhenghuayu;UDCA
37 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
38 Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy Completed NCT01576458 Phase 3 ursodeoxycholic acid;Placebo
39 Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption Completed NCT02200029 Phase 3 Ademetionine IV+tablet;Ademetionine tablet
40 A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction Completed NCT00433771 Phase 3
41 Effectiveness of Multicomponent Lipid Emulsion in Preterm Infants Requiring Parenteral Nutrition Completed NCT02663453 Phase 3 multicomponent lipid emulsion;pure soybean oil lipid emulsion
42 Paclitaxel Eluting Covered Metallic Stent for Unresectable Malignant Bile Duct Obstruction Completed NCT00453076 Phase 3
43 Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants Completed NCT02534077 Phase 3 Omegaven;Omegaven;Omegaven
44 Use of Omegaven Fish Oil Emulsion for Parenteral Nutrition Associated Liver Disease in Infants and Children Completed NCT01194063 Phase 3 Omega-3 fish oil lipid emulsion
45 Gabapentin to Treat Itch in Patients With Liver Disease Completed NCT00058890 Phase 3 Gabapentin;Placebo
46 Clinical Outcomes of EUS-guided Biliary Drainage Using Partially or Fully Covered Metallic Stents Completed NCT02114320 Phase 3
47 Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC Completed NCT01829698 Phase 3 tauroursodeoxycholic;ursodeoxycholic acid
48 Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis Completed NCT00844402 Phase 3 Atorvastatin
49 S-1 and Photodynamic Therapy in Cholangiocarcinoma Completed NCT00869635 Phase 3 S-1 Chemotherapy
50 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids

Search NIH Clinical Center for Cholestasis

Cochrane evidence based reviews: cholestasis

Genetic Tests for Cholestasis

Genetic tests related to Cholestasis:

# Genetic test Affiliating Genes
1 Cholestasis 30

Anatomical Context for Cholestasis

MalaCards organs/tissues related to Cholestasis:

42
Liver, Bone, Testes, Kidney, Placenta, Pancreas, Prostate

Publications for Cholestasis

Articles related to Cholestasis:

(show top 50) (show all 3331)
# Title Authors Year
1
Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis. ( 31051334 )
2019
2
Biliary atresia combined with progressive familial intrahepatic cholestasis type 3: A case report and review of the literature. ( 31083246 )
2019
3
A Rotavirus-Induced Mouse Model to Study Biliary Atresia and Neonatal Cholestasis. ( 31016660 )
2019
4
Relations of neuropeptide Y and heme oxygenase-1 expressions with fetal brain injury in rats with intrahepatic cholestasis of pregnancy. ( 31066785 )
2019
5
Association between bile salt export pump polymorphisms and intrahepatic cholestasis of pregnancy susceptibility: a meta-analysis of case-control studies. ( 30614300 )
2019
6
Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. ( 30620001 )
2019
7
SMOFlipid Protects Preterm Neonates against Perinatal Nutrition-Associated Cholestasis. ( 30620942 )
2019
8
Dyslipidemia, subclinical inflammation, hepatic cholestasis and endothelial dysfunction in schoolchildren with excess fat: A study from the United Arab Emirates. ( 30625218 )
2019
9
Risk factors associated with mortality in neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) and clinical implications. ( 30642297 )
2019
10
A Rare Cause of Neonatal Cholestasis Without Liver Dysfunction. ( 30664873 )
2019
11
Fish oil lipid emulsion to prevent cholestasis in preterm infants. ( 30679052 )
2019
12
Adjuvant Use of Rifampin for Refractory Intrahepatic Cholestasis of Pregnancy. ( 30681532 )
2019
13
Two Cases of Progressive Familial Intrahepatic Cholestasis Type 2: Role of Surgery with Brief Review of Literature. ( 30686894 )
2019
14
Inflammatory marker YKL-40 levels in intrahepatic cholestasis of pregnancy. ( 30688121 )
2019
15
Metabolic liver diseases presenting with neonatal cholestasis: at the crossroad between old and new paradigms. ( 30693370 )
2019
16
Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy. ( 30697260 )
2019
17
Assessment of cholestasis in drug-induced liver injury by different methods. ( 30732184 )
2019
18
Alagille syndrome: an uncommon cause of intrahepatic cholestasis in adults. ( 30746957 )
2019
19
Ultrasound findings in paediatric cholestasis: how to image the patient and what to look for. ( 30756259 )
2019
20
Benign Recurrent Intrahepatic Cholestasis Type 2 in Siblings with Novel ABCB11 Mutations. ( 30899697 )
2019
21
Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics. ( 30903105 )
2019
22
Cholestasis affects enteral tolerance and prospective weight gain in the NICU. ( 30904211 )
2019
23
Hemoadsorption in isolated conjugated hyperbilirubinemia after extracorporeal membrane oxygenation support. Cholestasis of sepsis: A case report and review of the literature on differential causes of jaundice in ICU patient. ( 30919732 )
2019
24
Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα. ( 30928103 )
2019
25
Severe and protracted cholestasis in 44 young men taking bodybuilding supplements: assessment of genetic, clinical and chemical risk factors. ( 30934130 )
2019
26
Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice. ( 30935993 )
2019
27
Severe cholestasis due to azathioprine in Behcet's disease. ( 30936327 )
2019
28
Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes. ( 30936968 )
2019
29
Early Onset Intrahepatic Cholestasis of Pregnancy: Is Progesterone Supplementation to be Blamed For? ( 30956477 )
2019
30
Escherichia coli-associated hemolytic uremic syndrome and severe chronic hepatocellular cholestasis: complication or side effect of eculizumab? ( 30963282 )
2019
31
Correlation of lipid peroxidation and ATP enzyme on erythrocyte membrane with fetal distress in the uterus in patients with intrahepatic cholestasis of pregnancy. ( 30964154 )
2019
32
Elevated hepatic MDR3/ABCB4 is directly mediated by MiR-378a-5p in human obstructive cholestasis. ( 30964181 )
2019
33
UHPLC-MS-based metabonomic analysis of intervention effects of Da-Huang-Xiao-Shi decoction on ANIT-induced cholestasis. ( 30965080 )
2019
34
Mechanisms and in vitro models of drug-induced cholestasis. ( 30972450 )
2019
35
Recessive Mutations in KIF12 Cause High Gamma-Glutamyltransferase Cholestasis. ( 30976738 )
2019
36
Hepatocarcinoma and Cholestasis Associated to Germline Hemizygous Deletion of Gene HNF1B. ( 29727438 )
2019
37
Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis. ( 29737914 )
2019
38
Paternal cholestasis exacerbates obesity-associated hypertension in male offspring but is prevented by paternal ursodeoxycholic acid treatment. ( 29795465 )
2019
39
Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood. ( 30102412 )
2019
40
Is It Necessary to Perform the Pharmacological Interventions for Intrahepatic Cholestasis of Pregnancy? A Bayesian Network Meta-Analysis. ( 30357607 )
2019
41
Enteral fish oil supplementation in the resolution of parenteral nutrition associated cholestasis. ( 30373963 )
2019
42
Animal models of cholestasis: An update on inflammatory cholangiopathies. ( 30398152 )
2019
43
Intestinal failure associated cholestasis in surgical necrotizing enterocolitis and spontaneous intestinal perforation. ( 30413273 )
2019
44
Steps Forward in the Management of Familial Cholestasis. ( 30418415 )
2019
45
Can mixed lipid emulsion prevent parenteral nutrition associated cholestasis? ( 30455473 )
2019
46
Diagnosis and prognosis of early-onset intrahepatic cholestasis of pregnancy: a prospective study. ( 29065754 )
2019
47
Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy with dichorionic diamniotic twin pregnancies. ( 29020816 )
2019
48
Percutaneous transgastral biliodigestive diversion as treatment option for benign recurrent intrahepatic cholestasis. ( 30339724 )
2019
49
An Intravenous Fish Oil-Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with Microvillous Inclusion Disease. ( 30311684 )
2019
50
Systematic review of progressive familial intrahepatic cholestasis. ( 30236549 )
2019

Variations for Cholestasis

ClinVar genetic disease variations for Cholestasis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC10A1 NM_003049.4(SLC10A1): c.745C> T (p.Arg249Trp) single nucleotide variant Uncertain significance rs76966244 GRCh37 Chromosome 14, 70245900: 70245900
2 SLC10A1 NM_003049.4(SLC10A1): c.745C> T (p.Arg249Trp) single nucleotide variant Uncertain significance rs76966244 GRCh38 Chromosome 14, 69779183: 69779183
3 SLC10A1 NM_003049.4(SLC10A1): c.601_611del (p.Ala201Serfs) deletion no interpretation for the single variant GRCh38 Chromosome 14, 69779317: 69779327
4 SLC10A1 NM_003049.4(SLC10A1): c.601_611del (p.Ala201Serfs) deletion no interpretation for the single variant GRCh37 Chromosome 14, 70246034: 70246044

Expression for Cholestasis

Search GEO for disease gene expression data for Cholestasis.

Pathways for Cholestasis

Pathways related to Cholestasis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 ABCB11 ABCB4 ABCC3 ALPP CYP7A1 GGT1
2
Show member pathways
12.04 ABCB11 ABCC3 CYP7A1 HSD3B7 NR1H4 SLC10A1
3 11.97 ABCC2 ABCC3 ABCC4 GGT1
4
Show member pathways
11.89 ABCB11 ABCB4 ABCC2 SLC10A1
5
Show member pathways
11.79 ABCB11 ABCC2 ABCC4
6
Show member pathways
11.7 NR1H4 NR1I2 NR1I3
7
Show member pathways
11.62 ABCC2 ABCC3 ABCC4
8 11.62 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 CYP7A1
9
Show member pathways
11.51 ABCC2 NR1I2 NR1I3
10 11.16 ABCC2 ABCC3 NR1I3
11 11.12 ABCC2 ABCC3 ABCC4
12 10.99 ABCC2 ABCC3 ABCC4
13 10.93 ABCB11 ABCB4 CYP7A1 NR1H4 SLC10A1
14
Show member pathways
10.88 ABCC2 ABCC3 ABCC4
15 10.84 ABCB11 ABCC2 ABCC3 ABCC4 CYP7A1 NR1H4
16 10.8 ABCC2 ABCC3 ABCC4
17 10.77 ABCB11 ABCB4 ABCC2 ABCC3 CYP7A1 NR1H4
18 10.76 ABCC3 NR1I2
19 10.69 ABCC2 NR1I2
20 10.54 ABCC2 ABCC3

GO Terms for Cholestasis

Cellular components related to Cholestasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.67 ABCB4 ABCC2 ATP8B1 JAG1
2 integral component of plasma membrane GO:0005887 9.56 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 JAG1
3 RNA polymerase II transcription factor complex GO:0090575 9.33 NR1H4 NR1I2 NR1I3
4 HOPS complex GO:0030897 9.26 VIPAS39 VPS33B
5 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2
6 membrane GO:0016020 10.2 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALPP

Biological processes related to Cholestasis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.7 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 SLC10A1
2 steroid hormone mediated signaling pathway GO:0043401 9.61 NR1H4 NR1I2 NR1I3
3 phospholipid translocation GO:0045332 9.54 ABCB4 ATP8B1
4 intracellular receptor signaling pathway GO:0030522 9.54 NR1H4 NR1I2 NR1I3
5 collagen metabolic process GO:0032963 9.52 VIPAS39 VPS33B
6 bile acid metabolic process GO:0008206 9.51 ATP8B1 NR1H4
7 bile acid biosynthetic process GO:0006699 9.5 ABCB11 CYP7A1 HSD3B7
8 cholesterol catabolic process GO:0006707 9.49 CYP7A1 HSD3B7
9 peptidyl-lysine hydroxylation GO:0017185 9.46 VIPAS39 VPS33B
10 regulation of bile acid biosynthetic process GO:0070857 9.4 CYP7A1 NR1H4
11 drug transmembrane transport GO:0006855 9.26 ABCC2 ATP8B1
12 xenobiotic transport GO:0042908 9.18 NR1I2
13 canalicular bile acid transport GO:0015722 9.13 ABCB11 ABCC2 ABCC3
14 bile acid and bile salt transport GO:0015721 9.02 ABCB11 ABCC3 ATP8B1 NR1H4 SLC10A1

Molecular functions related to Cholestasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transporter activity GO:0022857 9.63 ABCC2 ABCC3 SLC25A13
2 transcription regulatory region sequence-specific DNA binding GO:0000976 9.58 NR1H4 NR1I2 NR1I3
3 ATPase activity GO:0016887 9.55 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4
4 nuclear receptor transcription coactivator activity GO:0030374 9.54 NR1H4 NR1I2 NR1I3
5 steroid hormone receptor activity GO:0003707 9.5 NR1H4 NR1I2 NR1I3
6 organic anion transmembrane transporter activity GO:0008514 9.43 ABCC2 ABCC3
7 nuclear receptor activity GO:0004879 9.43 NR1H4 NR1I2 NR1I3
8 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.02 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4
9 bile acid-exporting ATPase activity GO:0015432 8.96 ABCB11 ABCC3

Sources for Cholestasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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