MCID: CHL068
MIFTS: 60

Cholestasis

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Cholestasis

MalaCards integrated aliases for Cholestasis:

Name: Cholestasis 12 76 29 55 44 15 73
Obstruction of Bile Duct 12
Bile Duct Obstruction 55
Bile Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13580
ICD10 33 K83.1
ICD9CM 35 576.2
MeSH 44 D002779
NCIt 50 C83006
UMLS 73 C0008370

Summaries for Cholestasis

MalaCards based summary : Cholestasis, also known as obstruction of bile duct, is related to cholestasis, benign recurrent intrahepatic, 1 and cholestasis, progressive familial intrahepatic, 2, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Cholestasis is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways/superpathways are Synthesis of bile acids and bile salts and NRF2 pathway. The drugs Ursodeoxycholic acid and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and placenta, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Cholestasis is a condition where bile cannot flow from the liver to the duodenum. The two basic... more...

Related Diseases for Cholestasis

Diseases related to Cholestasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 cholestasis, benign recurrent intrahepatic, 1 34.7 ABCB11 ATP8B1
2 cholestasis, progressive familial intrahepatic, 2 34.7 ABCB11 ABCB4 ATP8B1
3 cholestasis, progressive familial intrahepatic, 3 34.4 ABCB11 ABCB4 ATP8B1 JAG1
4 arthrogryposis, renal dysfunction, and cholestasis 1 33.9 VIPAS39 VPS33B
5 cholestasis, progressive familial intrahepatic, 1 33.8 ABCB11 ABCB4 ATP8B1 GGT1 JAG1 NR1H4
6 alagille syndrome 1 33.7 ABCB4 ATP8B1 JAG1
7 atp8b1 deficiency 32.8 ABCB11 ATP8B1 NR1H4
8 extrahepatic cholestasis 32.5 ABCB4 ABCC2 ABCC3 CYP7A1 GGT1
9 biliary atresia, extrahepatic 32.1 GGT1 JAG1
10 biliary atresia 31.5 ATP8B1 JAG1 NR1H4 SLC10A1
11 primary biliary cirrhosis 31.4 ABCB4 ABCC3 ALPP GGT1 NR1H4
12 cholangitis 30.5 ABCB11 ABCB4 GGT1
13 sclerosing cholangitis 30.4 ABCB11 ABCB4 GGT1 NR1I2
14 intrahepatic cholestasis 30.2 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 GGT1
15 cholangitis, primary sclerosing 30.2 ABCB4 GGT1 NR1I2
16 cholelithiasis 30.1 ABCB4 CYP7A1 NR1H4
17 dubin-johnson syndrome 30.1 ABCC2 ABCC3 ABCC4
18 obstructive jaundice 30.0 ALPP GGT1 SLC25A13
19 liver disease 29.9 ABCB11 ABCB4 ATP8B1 GGT1 HSD3B7 NR1H4
20 xanthomatosis 29.7 CYP7A1 NR1H4 NR1I2
21 gastrointestinal system disease 29.4 ABCB11 GGT1 NR1I2
22 cerebrotendinous xanthomatosis 29.3 CYP7A1 NR1H4 NR1I2
23 cholestasis, intrahepatic, of pregnancy, 1 12.4
24 cholestasis, benign recurrent intrahepatic, 2 12.4
25 cholestasis-lymphedema syndrome 12.3
26 cholestasis, intrahepatic, of pregnancy 3 12.3
27 cholestasis, progressive familial intrahepatic, 4 12.2
28 cholestasis, progressive familial intrahepatic, 5 12.2
29 arthrogryposis, renal dysfunction, and cholestasis 2 12.2
30 citrullinemia, type ii, neonatal-onset 12.0
31 cholestasis with gallstone, ataxia, and visual disturbance 11.8
32 myo5b-related progressive familial intrahepatic cholestasis 11.8
33 bile acid synthesis defect, congenital, 2 11.7
34 gracile syndrome 11.7
35 bile acid synthesis defect, congenital, 1 11.7
36 bile acid synthesis defect, congenital, 4 11.6
37 alagille syndrome 2 11.4
38 hardikar syndrome 11.3
39 citrullinemia, type ii, adult-onset 11.2
40 primary biliary cholangitis 11.1
41 niemann-pick disease, type c1 11.1
42 crigler-najjar syndrome, type ii 11.1
43 hyperbiliverdinemia 11.0
44 gallbladder disease 1 11.0
45 bile acid synthesis defect, congenital, 3 10.9
46 sclerosing cholangitis, neonatal 10.9
47 congenital bile acid synthesis defect 10.8
48 amyloidosis, familial visceral 10.7
49 gilbert syndrome 10.7
50 lambert syndrome 10.7

Comorbidity relations with Cholestasis via Phenotypic Disease Network (PDN): (show all 17)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Biliary Tract Neoplasm
Cholangitis Cholecystitis
Deficiency Anemia Duodenum Cancer
Esophagitis Gallbladder Cancer
Gastrointestinal System Cancer Intrahepatic Gall Duct Cancer
Pancreatic Agenesis 1 Pancreatic Cancer
Pancreatitis, Hereditary Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Cholestasis:



Diseases related to Cholestasis

Symptoms & Phenotypes for Cholestasis

UMLS symptoms related to Cholestasis:


icterus, jaundice (not of newborn)

GenomeRNAi Phenotypes related to Cholestasis according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.46 TJP2 NR1I2 NR1I3
2 Decreased viability GR00221-A-2 10.46 TJP2 NR1H4 NR1I2 NR1I3
3 Decreased viability GR00221-A-3 10.46 TJP2
4 Decreased viability GR00221-A-4 10.46 TJP2 NR1H4
5 Decreased viability GR00240-S-1 10.46 TJP2
6 Decreased viability GR00301-A 10.46 NR1I2 NR1I3
7 Decreased viability GR00342-S-3 10.46 TJP2
8 Decreased viability GR00381-A-1 10.46 GGT1 HSD3B7 ABCC2 TJP2
9 Decreased viability GR00381-A-2 10.46 ABCC2
10 Decreased viability GR00381-A-3 10.46 ABCC2
11 Decreased viability GR00402-S-2 10.46 UTP4 VIPAS39 VPS33B HSD3B7 JAG1 NR1H4
12 no effect GR00402-S-1 9.62 ABCC4 ALPP ATP8B1 CYP7A1 GGT1 HSD3B7
13 Downregulation of NF-kappaB pathway after TNFalpha stimulation GR00199-A-2 9.13 NR1H4 TJP2 UTP4

MGI Mouse Phenotypes related to Cholestasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ABCB11 ABCB4 ABCC4 ATP8B1 CYP7A1 GGT1
2 homeostasis/metabolism MP:0005376 10.13 NR1I2 NR1I3 SLC25A13 VPS33B ABCB11 ABCB4
3 integument MP:0010771 9.81 ABCC3 ABCC4 CYP7A1 GGT1 HSD3B7 JAG1
4 liver/biliary system MP:0005370 9.73 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 CYP7A1
5 mortality/aging MP:0010768 9.44 JAG1 NR1H4 NR1I2 NR1I3 SLC25A13 TJP2

Drugs & Therapeutics for Cholestasis

Drugs for Cholestasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 280)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 128-13-2 31401
2
Acetylcysteine Approved, Investigational Phase 4,Not Applicable 616-91-1 12035
3
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1 474-25-9 10133
4
Glycerol Approved, Investigational Phase 4 56-81-5 753
5
Abatacept Approved Phase 4 332348-12-6 10237
6
Sorbitol Approved Phase 4 50-70-4 5780
7
Methionine Approved, Nutraceutical Phase 4,Phase 3,Phase 2 63-68-3 6137
8
Choline Approved, Nutraceutical Phase 4 62-49-7 305
9 Coconut Approved, Nutraceutical Phase 4,Not Applicable
10
Tocopherol Approved, Investigational, Nutraceutical Phase 4,Phase 3 1406-66-2 14986
11
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-02-9 14985
12 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
15 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Nootropic Agents Phase 4
18 Polyene phosphatidylcholine Phase 4
19 Bile Acids and Salts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Fat Emulsions, Intravenous Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
21 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Parenteral Nutrition Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
23 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Soybean oil, phospholipid emulsion Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Cholagogues and Choleretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Respiratory System Agents Phase 4,Phase 3,Phase 1,Not Applicable
27 Antidotes Phase 4,Not Applicable
28 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Expectorants Phase 4,Not Applicable
31 N-monoacetylcystine Phase 4,Not Applicable
32 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Cathartics Phase 4,Phase 3,Phase 2,Early Phase 1
34 Laxatives Phase 4,Phase 3,Phase 2,Early Phase 1
35 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Not Applicable
37 Tocopherols Phase 4,Phase 3
38 Tocotrienols Phase 4,Phase 3
39 Lecithin Nutraceutical Phase 4
40 Olive Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
41 Soy Bean Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Omega 3 Fatty Acid Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Phytosterol Nutraceutical Phase 4
44 Tocotrienol Investigational, Nutraceutical Phase 4,Phase 3 6829-55-6
45
Fenofibrate Approved Phase 3,Phase 2,Phase 1 49562-28-9 3339
46
Bezafibrate Approved, Investigational Phase 3 41859-67-0 39042
47
Ethanol Approved Phase 3 64-17-5 702
48
Paclitaxel Approved, Vet_approved Phase 3,Phase 1 33069-62-4 36314
49
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
50
gamma-Aminobutyric acid Approved, Investigational Phase 3 56-12-2 119

Interventional clinical trials:

(show top 50) (show all 347)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis Unknown status NCT01998620 Phase 4 Ademetionine 2;Ademetionine 1;Ademetionine 3
2 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
3 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
4 Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion Unknown status NCT01786759 Phase 4 ClinOleic;Intralipid
5 Preventing Cholestasis Using SMOFLipid® Completed NCT01585935 Phase 4 SMOFLIPID;INTRALIPID
6 The Preventative and Therapeutical Effect of Ursodeoxycholic Acid(UDCA) to Short Bowel Syndrome Patients Completed NCT01974336 Phase 4 ursodeoxycholic acid
7 Pilot Study: Hepatoprotective Role of SMOFlipid® Used in Short-term Parenteral Nutrition in an Onco-Hematology Pediatric Population Completed NCT02539316 Phase 4 Smoflipid;Médialipides
8 RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction Completed NCT00980889 Phase 4
9 The Usefulness of Endoscopic Ultrasound-guided Biliary Drainage With a Newly Designed Hybrid Metallic Stent Completed NCT01862198 Phase 4
10 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
11 Antegrade Arterial and Portal Flushing Versus Portal Flushing Only in LDLT Completed NCT03048318 Phase 4
12 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
13 Comparing Covered Self-expandable Metallic Stent (SEMS) Above/Across the Sphincter of Oddi Completed NCT01041612 Phase 4
14 N-acetylcysteine to Reduce Ischemia/Reperfusion Injury in Liver Resection Completed NCT01223326 Phase 4 Acetylcysteine (NAC);Saline
15 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
16 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4 UDCA (Ursodeoxycholic acid);UDCA (Ursodeoxycholic acid)
17 Evaluation of Glycerin Suppositories to Improve Bowel Function in Gastroschisis Recruiting NCT03355326 Phase 4 Glycerin Suppository
18 Use of Omega-3 Fat Emulsion (Omegaven) in Infants With Parenteral Nutrition Associated Liver Disease Recruiting NCT00862446 Phase 4 Omegaven
19 WallFlex Biliary Fully Covered (FC) Chronic Pancreatitis Study Recruiting NCT01543256 Phase 4
20 A Trial of 18-22mg/kg/d Ursodeoxycholic in Refractory Primary Biliary Cholangitis Recruiting NCT03345589 Phase 4 18-22mg/kg/d Ursodeoxycholic;13-15mg/kg/d Ursodeoxycholic
21 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
22 Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis Active, not recruiting NCT02078882 Phase 4
23 Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid Emulsions Terminated NCT02633384 Phase 4
24 Low Dose Fat for the Prevention of Liver Disease in Babies With Gastrointestinal Disorders Terminated NCT01373918 Phase 4 Intralipid;Intralipid
25 Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion Terminated NCT02476994 Phase 4 Clinolipid;Intralipid
26 SMOFLipid in Patients Who Are Intralipid Intolerant Withdrawn NCT03054948 Phase 4 SMOFLipid;Standard therapy
27 Minimization of IntraLipid Versus Omegaven Unknown status NCT01247012 Phase 2, Phase 3
28 Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid Unknown status NCT02823366 Phase 3 Fenofibrate;UDCA
29 Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Unknown status NCT02823353 Phase 3 Fenofibrate;UDCA
30 The Effect of Bezafibrate on Cholestatic Itch Unknown status NCT02701166 Phase 3 Bezafibrate;Placebo
31 WallFlex Biliary Fully Covered (FC) Benign Stricture Study Unknown status NCT01014390 Phase 3
32 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
33 Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy Completed NCT01576458 Phase 3 ursodeoxycholic acid;Placebo
34 Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption Completed NCT02200029 Phase 3 Ademetionine IV+tablet;Ademetionine tablet
35 A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction Completed NCT00433771 Phase 3
36 Effectiveness of Multicomponent Lipid Emulsion in Preterm Infants Requiring Parenteral Nutrition Completed NCT02663453 Phase 3 multicomponent lipid emulsion;pure soybean oil lipid emulsion
37 Paclitaxel Eluting Covered Metallic Stent for Unresectable Malignant Bile Duct Obstruction Completed NCT00453076 Phase 3
38 Gabapentin to Treat Itch in Patients With Liver Disease Completed NCT00058890 Phase 3 Gabapentin;Placebo
39 Clinical Outcomes of EUS-guided Biliary Drainage Using Partially or Fully Covered Metallic Stents Completed NCT02114320 Phase 3
40 Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC Completed NCT01829698 Phase 3 tauroursodeoxycholic;ursodeoxycholic acid
41 Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis Completed NCT00844402 Phase 3 Atorvastatin
42 S-1 and Photodynamic Therapy in Cholangiocarcinoma Completed NCT00869635 Phase 3 S-1 Chemotherapy
43 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids
44 A Clinical Trial to Assess the Efficacy and Safety of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-383) Completed NCT02550288 Phase 3 Ezetimibe 10 mg;Atorvastatin 10 mg;Placebo for Ezetimibe 10 mg tablet;Placebo for Atorvastatin 10 mg capsule
45 A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-384) Completed NCT02460159 Phase 3 EZ 10 mg/Atorva 20 mg FDC;EZ 10 mg/Atorva 10 mg FDC
46 A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832) Completed NCT02741245 Phase 3 Ezetimibe 10 mg;Rosuvastatin 2.5 mg;Placebo for Ezetimibe;Placebo for Rosuvastatin
47 Safety and Efficacy of Linagliptin (BI 1356) as Monotherapy or in Combination in Type 2 DM Completed NCT00736099 Phase 3 linagliptine 5 mg;linagliptine 5 mg and pioglitazone 30 mg
48 Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Completed NCT01654731 Phase 3 Bezafibrate;placebo
49 Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis Completed NCT01857284 Phase 3 Tauroursodeoxycholic Acid Capsules;Ursodeoxycholic Acid Capsules
50 Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary Cirrhosis Completed NCT00805805 Phase 3 Tetrathiomolybdate

Search NIH Clinical Center for Cholestasis

Cochrane evidence based reviews: cholestasis

Genetic Tests for Cholestasis

Genetic tests related to Cholestasis:

# Genetic test Affiliating Genes
1 Cholestasis 29

Anatomical Context for Cholestasis

MalaCards organs/tissues related to Cholestasis:

41
Liver, Bone, Placenta, Testes, Pancreas, Brain, Heart

Publications for Cholestasis

Articles related to Cholestasis:

(show top 50) (show all 1741)
# Title Authors Year
1
Prostaglandin E1 Preconditioning Attenuates Liver Ischemia Reperfusion Injury in a Rat Model of Extrahepatic Cholestasis. ( 29511679 )
2018
2
Spectrum of genomic variations in Indian patients with progressive familial intrahepatic cholestasis. ( 29973134 )
2018
3
Treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid associated with improvement of fetal first-degree atrioventricular block. ( 29484735 )
2018
4
Correlation of APRI Index with Metavir Index in Children with Neonatal Cholestasis Without Biliary Atresia. ( 29893700 )
2018
5
Epididymal ultrastructural changes associated with chronic cholestasis after bile duct ligation in adult rats. ( 29952690 )
2018
6
Bile duct obstruction in a patient treated with nivolumab as second-line chemotherapy for advanced non-small-cell lung cancer: a case report. ( 28913619 )
2018
7
Nutritional therapy complications in children with ultra-short bowel syndrome include growth deficiency but not cholestasis. ( 29405447 )
2018
8
Diagnostic and therapeutic profiles of serum bile acids in women with intrahepatic cholestasis of pregnancy-a pseudo-targeted metabolomics study. ( 29709452 )
2018
9
Long-term outcome after cholecystocolostomy for progressive familial intrahepatic cholestasis. ( 29934967 )
2018
10
Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. ( 29718219 )
2018
11
Yinchenhao Decoction Ameliorates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis in Rats by Regulating Phase II Metabolic Enzymes and Transporters. ( 29867509 )
2018
12
Role of the placenta in serum autotaxin elevation during maternal cholestasis. ( 29927323 )
2018
13
Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease. ( 29431335 )
2018
14
Development of a Novel Tool to Assess the Impact of Itching in Pediatric Cholestasis. ( 28710680 )
2018
15
The pruritus of cholestasis: From bile acids to opiate agonists: Relevant after all these years. ( 29317077 )
2018
16
Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome. ( 29541472 )
2018
17
Intrahepatic cholestasis of pregnancy and associated causes of death: a cohort study with follow-up of 27-46A years. ( 29914448 )
2018
18
Effect of inducible nitric oxide synthase and neuropeptide Y in plasma and placentas from intrahepatic cholestasis of pregnancy. ( 29956420 )
2018
19
Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1I+. ( 29360226 )
2018
20
Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estrogen sulfotransferase SULT1E1. ( 29929982 )
2018
21
Chronic cholestasis is associated with hypogonadism and premature ovarian failure in adult rats (cholestasis causes ovarian hypogonadism). ( 29297778 )
2018
22
Splicing analysis of rare/novel synonymous or intronic variants identified in ABCB11 heterozygotes presenting as progressive intrahepatic cholestasis with low I^-glutamyltransferase. ( 29316097 )
2018
23
Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies. ( 29507303 )
2018
24
Lipidomics reveal Aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate(ANIT)-induced intrahepatic cholestasis. ( 29737914 )
2018
25
Lemmel's Syndrome: A Rare Cause of Cholestasis. ( 29855418 )
2018
26
Resveratrol Regulating SIRT1-NF-I_B Signal Pathway in Intrahepatic Cholestasis of Pregnancy. ( 29855113 )
2018
27
Protective effects of yangonin from an edible botanical Kava against lithocholic acid-induced cholestasis and hepatotoxicity. ( 29427579 )
2018
28
Ursodeoxycholic acid versus phenobarbital for cholestasis in the Neonatal Intensive Care Unit. ( 29925342 )
2018
29
Assessment of circulating betatrophin levels in intrahepatic cholestasis of pregnancy. ( 29890866 )
2018
30
Different effects of ursodeoxycholic acid on intrahepatic cholestasis in acute and recovery stages induced by alpha-naphthylisothiocyanate in mice. ( 29407775 )
2018
31
Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target. ( 29328070 )
2018
32
Benign recurrent intrahepatic cholestasis (BRIC)-like episode associated with ATP8B1 variation underlying protracted cholestatic course of acute hepatitis E virus infection. ( 29191380 )
2018
33
Cholestasis after TIPS placement in a patient with primary sclerosing cholangitis: an uncommon complication. ( 29278002 )
2018
34
Giant Right Atrial Aneurysm Accompanying Intrahepatic Cholestasis. ( 29682357 )
2018
35
Reduced Immunohistochemical Expression of Hnf1I^ and FoxA2 in Liver Tissue Can Discriminate Between Biliary Atresia and Other Causes of Neonatal Cholestasis. ( 29406331 )
2018
36
Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages. ( 29104077 )
2018
37
Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis. ( 29792896 )
2018
38
Perinatal outcomes in intrahepatic cholestasis of pregnancy with monochorionic diamniotic twin pregnancy. ( 29980184 )
2018
39
Reduced Hepatocellular Expression of Canalicular Transport Proteins in Infants with Neonatal Cholestasis and Congenital Hypopituitarism. ( 29935878 )
2018
40
Loss-of-Function Mutations in UNC45A Cause a Syndrome Associating Cholestasis, Diarrhea, Impaired Hearing, and Bone Fragility. ( 29429573 )
2018
41
Does ursodeoxycholic acid improve perinatal outcomes in women with intrahepatic cholestasis of pregnancy? ( 29419378 )
2018
42
Low serum vitamin D level is associated with intrahepatic cholestasis of pregnancy. ( 29978524 )
2018
43
Detection of Cytomegalovirus in Liver Tissue by PCR in Infants with Neonatal Cholestasis. ( 29389827 )
2018
44
Can genetic testing guide the therapy of cholestatic pruritus? A case of benign recurrent intrahepatic cholestasis type 2 with severe nasobiliary drainage-refractory itch. ( 29404523 )
2018
45
Predicting drug-induced cholestasis: preclinical models. ( 29888962 )
2018
46
Outcomes of surgical management of familial intrahepatic cholestasis 1 and bile salt export protein deficiencies. ( 29761168 )
2018
47
Dehydrated Hereditary Stomatocytosis Presenting as Severe Perinatal Ascites and Cholestasis. ( 29952828 )
2018
48
Intrahepatic cholestasis of pregnancy: Shorter duration of labor? ( 29680685 )
2018
49
SCYL1 variants cause a syndrome with low I^-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN). ( 29419818 )
2018
50
Regulation of Epithelial Injury and Bile Duct Obstruction by NLRP3 and IL-1R1 in Experimental Biliary Atresia. ( 29886157 )
2018

Variations for Cholestasis

Expression for Cholestasis

Search GEO for disease gene expression data for Cholestasis.

Pathways for Cholestasis

Pathways related to Cholestasis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 ABCB11 ABCC3 CYP7A1 HSD3B7 NR1H4 SLC10A1
2 11.97 ABCC2 ABCC3 ABCC4 GGT1
3
Show member pathways
11.92 ABCC2 ABCC3 ABCC4
4
Show member pathways
11.89 ABCB11 ABCB4 ABCC2 SLC10A1
5
Show member pathways
11.7 NR1H4 NR1I2 NR1I3
6
Show member pathways
11.67 ABCB11 ABCC2 ABCC4
7
Show member pathways
11.62 ABCC2 ABCC3 ABCC4
8 11.61 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 CYP7A1
9
Show member pathways
11.45 ABCC2 NR1I2 NR1I3
10 11.16 ABCC2 ABCC3 NR1I3
11 11.12 ABCC2 ABCC3 ABCC4
12 10.99 ABCC2 ABCC3 ABCC4
13 10.93 ABCB11 ABCB4 CYP7A1 NR1H4 SLC10A1
14
Show member pathways
10.88 ABCC2 ABCC3 ABCC4
15 10.84 ABCB11 ABCC2 ABCC3 ABCC4 CYP7A1 NR1H4
16 10.8 ABCC2 ABCC3 ABCC4
17 10.77 ABCB11 ABCB4 ABCC2 ABCC3 CYP7A1 NR1H4
18 10.76 ABCC3 NR1I2
19 10.69 ABCC2 NR1I2
20 10.54 ABCC2 ABCC3

GO Terms for Cholestasis

Cellular components related to Cholestasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.73 ABCB4 ABCC2 ATP8B1 JAG1
2 integral component of plasma membrane GO:0005887 9.61 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
3 apical part of cell GO:0045177 9.5 ABCB11 ABCB4 JAG1
4 RNA polymerase II transcription factor complex GO:0090575 9.43 NR1H4 NR1I2 NR1I3
5 HOPS complex GO:0030897 9.37 VIPAS39 VPS33B
6 brush border membrane GO:0031526 9.33 ABCB4 ABCC2 ATP8B1
7 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2
8 membrane GO:0016020 10.28 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALPP

Biological processes related to Cholestasis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.95 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 SLC10A1
2 cellular response to lipopolysaccharide GO:0071222 9.83 ABCC2 NR1H4 NR1I2 NR1I3
3 steroid hormone mediated signaling pathway GO:0043401 9.76 NR1H4 NR1I2 NR1I3
4 cholesterol homeostasis GO:0042632 9.73 CYP7A1 NR1H4 NR1I2 NR1I3
5 intracellular receptor signaling pathway GO:0030522 9.72 NR1H4 NR1I2 NR1I3
6 response to lipid GO:0033993 9.67 NR1H4 NR1I2 NR1I3
7 bile acid biosynthetic process GO:0006699 9.65 ABCB11 CYP7A1 HSD3B7
8 phospholipid translocation GO:0045332 9.62 ABCB4 ATP8B1
9 intestinal absorption GO:0050892 9.62 ABCB4 TJP2
10 response to glucagon GO:0033762 9.61 ABCB4 ABCC2
11 bile acid metabolic process GO:0008206 9.6 ATP8B1 NR1H4
12 collagen metabolic process GO:0032963 9.59 VIPAS39 VPS33B
13 peptidyl-lysine hydroxylation GO:0017185 9.58 VIPAS39 VPS33B
14 drug export GO:0046618 9.57 ABCB4 NR1I2
15 response to antineoplastic agent GO:0097327 9.56 ABCB4 ABCC2
16 lipid homeostasis GO:0055088 9.56 ABCB4 NR1H4 NR1I2 NR1I3
17 regulation of bile acid biosynthetic process GO:0070857 9.54 CYP7A1 NR1H4
18 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.54 ABCC2 ABCC3 ABCC4
19 aromatic compound biosynthetic process GO:0019438 9.51 NR1I2 NR1I3
20 xenobiotic transport GO:0042908 9.5 ABCB4 ABCC3 NR1I2
21 heterocycle biosynthetic process GO:0018130 9.46 NR1I2 NR1I3
22 drug transmembrane transport GO:0006855 9.46 ABCB4 ABCC2 ABCC3 ATP8B1
23 canalicular bile acid transport GO:0015722 9.13 ABCB11 ABCC2 ABCC3
24 bile acid and bile salt transport GO:0015721 9.02 ABCB11 ABCC3 ATP8B1 NR1H4 SLC10A1
25 lipid metabolic process GO:0006629 10.01 ABCB4 CYP7A1 NR1H4 NR1I2 NR1I3

Molecular functions related to Cholestasis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.77 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4
2 transcription regulatory region sequence-specific DNA binding GO:0000976 9.69 NR1H4 NR1I2 NR1I3
3 ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 9.67 NR1H4 NR1I2 NR1I3
4 steroid hormone receptor activity GO:0003707 9.63 NR1H4 NR1I2 NR1I3
5 nuclear receptor activity GO:0004879 9.61 NR1H4 NR1I2 NR1I3
6 transcription factor activity, RNA polymerase II transcription factor binding GO:0001076 9.58 NR1H4 NR1I2 NR1I3
7 xenobiotic transmembrane transporting ATPase activity GO:0008559 9.48 ABCB4 ABCC3
8 transcription factor activity, direct ligand regulated sequence-specific DNA binding GO:0098531 9.43 NR1H4 NR1I2 NR1I3
9 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.33 ABCC2 ABCC3 ABCC4
10 bile acid-exporting ATPase activity GO:0015432 9.32 ABCB11 ABCC3
11 thyroid hormone receptor activity GO:0004887 9.13 NR1H4 NR1I2 NR1I3
12 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.02 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4

Sources for Cholestasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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