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MCID: CHL122
MIFTS: 50

Cholesteatoma of Middle Ear

Categories: Ear diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cholesteatoma of Middle Ear

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MalaCards integrated aliases for Cholesteatoma of Middle Ear:

Name: Cholesteatoma of Middle Ear 12 15 17 32
Cholesteatoma 12 52 54 43 15 17 71
Middle Ear Cholesteatoma 12 71
Cholesteatoma of Middle Ear and/or Mastoid 12
Cholesteatoma of Middle Ear and Mastoid 12
Secondary Acquired Cholesteatoma 52
Cholesteatoma of the Middle Ear 12
Primary Acquired Cholesteatoma 52
Epidermosis of Middle Ear 12
Cholesteatoma, Middle Ear 43
Congenital Cholesteatoma 52
Cholesteatoma Middle Ear 54
Epidermosis of Ear 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Ear diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10964 DOID:869
NCIt 49 C2944 C3654
ICD10 32 H71 H71.9
UMLS 71 C0008373 C0008374 C0155490
Sources

Summaries for Cholesteatoma of Middle Ear

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NIH Rare Diseases : 52 Cholesteatoma is an abnormal growth of skin in the middle ear behind the eardrum . It can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infections. Individuals with this condition usually experience a painless discharge from the ear. Hearing loss , dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth. Treatment usually involves surgery to remove the growth.

MalaCards based summary : Cholesteatoma of Middle Ear, also known as cholesteatoma, is related to keratosis and proteasome-associated autoinflammatory syndrome 1, and has symptoms including earache An important gene associated with Cholesteatoma of Middle Ear is MIR21 (MicroRNA 21), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Clonidine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and skin, and related phenotype is integument.

Wikipedia : 74 Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in... more...

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Related Diseases for Cholesteatoma of Middle Ear

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Diseases related to Cholesteatoma of Middle Ear via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 369)
# Related Disease Score Top Affiliating Genes
1 keratosis 30.9 MMP9 KRT10 IVL FLG
2 proteasome-associated autoinflammatory syndrome 1 30.4 MMP9 IL1A ICAM1
3 papilloma 30.2 TGFA KRT13 KRT10 IVL FLG
4 osteonecrosis 30.2 TNFSF11 TNFRSF11B FGF2
5 bone inflammation disease 30.1 TNFSF11 TNFRSF11B MMP9 MIR21 IL1A
6 squamous cell carcinoma 30.0 TGFA MMP9 KRT13 IVL FGFR2 EGF
7 nevus, epidermal 29.9 KRT10 IVL FGFR2
8 epidermolytic hyperkeratosis 29.8 KRT16 KRT10 IVL FLG
9 crouzon syndrome 29.7 FGFR2 FGF7 FGF2
10 endosteal hyperostosis, autosomal dominant 29.7 TNFSF11 TNFRSF11B EGF
11 bronchial disease 29.7 MIR21 ICAM1 FLG
12 ankylosis 29.7 TNFSF11 TNFRSF11B FGFR2
13 dermatitis, atopic 29.5 IVL IL1A ICAM1 FLG DEFB4A
14 basal cell carcinoma 29.4 MMP9 KRT16 KRT10 IVL ICAM1
15 bone disease 29.4 TNFSF11 TNFRSF11B MMP9 IL1A ICAM1 FGFR2
16 hydronephrosis 29.4 MMP9 ICAM1 EGF
17 periodontitis 29.2 TNFSF11 TNFRSF11B MMP9 MIR21 IL1A ICAM1
18 scoliosis 29.0 TNFSF11 TNFRSF11B MMP9 FGFR2 FGF2
19 osteoporosis 28.7 TNFSF11 TNFRSF11B MMP9 MIR21 IL1A ICAM1
20 skin disease 27.9 TGFA MIR21 KRT16 KRT10 IVL IL1A
21 cholesteatoma of external ear 12.8
22 maxillary sinus cholesteatoma 12.6
23 cholesteatoma of attic 12.4
24 cholesteatoma, congenital 12.3
25 purulent labyrinthitis 11.6
26 focal labyrinthitis 11.6
27 otitis media 11.1
28 facial paralysis 10.8
29 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.8
30 bone resorption disease 10.7
31 suppurative otitis media 10.7
32 chronic purulent otitis media 10.7
33 perilymphatic fistula 10.7
34 sensorineural hearing loss 10.6
35 branchiootic syndrome 1 10.6
36 epidermoid cysts 10.6
37 villonodular synovitis 10.5 TNFSF11 MMP9
38 mastoiditis 10.5
39 meningitis 10.5
40 bazex syndrome 10.5 TGFA FGF7
41 middle ear disease 10.5
42 acute pericementitis 10.5 TNFSF11 DEFB4A
43 chronic actinic dermatitis 10.4 MMP9 FLG
44 labyrinthitis 10.4
45 auditory system disease 10.4
46 marginal corneal ulcer 10.4 IL1A FGF7 DEFB4A
47 oral cancer 10.4 MMP9 MIR21 KRT13
48 otosclerosis 10.4
49 otitis externa 10.3
50 anal fistula 10.3 MMP9 EGF DEFB4A

Comorbidity relations with Cholesteatoma of Middle Ear via Phenotypic Disease Network (PDN):


Otitis Media

Graphical network of the top 20 diseases related to Cholesteatoma of Middle Ear:



Diseases related to Cholesteatoma of Middle Ear
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Symptoms & Phenotypes for Cholesteatoma of Middle Ear

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UMLS symptoms related to Cholesteatoma of Middle Ear:


earache

MGI Mouse Phenotypes related to Cholesteatoma of Middle Ear:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.28 EGF FGF7 FGFR2 ICAM1 IL1A KRT16
Sources

Drugs & Therapeutics for Cholesteatoma of Middle Ear

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Drugs for Cholesteatoma of Middle Ear (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 2 4205-90-7 2803
2
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
3 Anesthetics Phase 2
4 Adrenergic alpha-Agonists Phase 2
5 Antihypertensive Agents Phase 2
6 Adrenergic Agents Phase 2
7 Sympatholytics Phase 2
8 Analgesics Phase 2
9 Anesthetics, Local Phase 2
10 Adrenergic Agonists Phase 2
11 Neurotransmitter Agents Phase 2
12
Lidocaine Approved, Vet_approved 137-58-6 3676
13 Anti-Infective Agents, Local
14 Anti-Bacterial Agents
15 Anti-Infective Agents

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Use of Biodesign® Otologic Graft in Canal Wall Down Mastoidectomy: A Prospective, Randomized Trial Recruiting NCT03902938 Phase 4
2 Great Auricular Nerve Block for Children Undergoing Tympanomastoid Surgery: Does the Addition of Clonidine Increase the Duration of Postoperative Analgesia? Completed NCT01638052 Phase 2 0.25% Bupivacaine + Clonidine
3 Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging Unknown status NCT03305796
4 Combined Access Closed Tympanomastoidectomy: Microsurgery Allied to Endoscopy Unknown status NCT03294421
5 Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas Unknown status NCT02903550
6 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
7 A Cross Sectional Study of Clinicopathologic Behaviour of Primary, Secondary and Mixed Types of Atticoantral Chronic Otitis Media Unknown status NCT00270660
8 Evaluation of Prognostic Factors and Middle Ear Risk Index in Tympanoplasty Unknown status NCT03416725
9 Balloon Dilation of the Eustachian Tube, a Lower Pressure Challenge Unknown status NCT03322579
10 Messung Der Beweglichkeit Der Gehörknöchelchenkette während Einer Ohroperation. ("Objective Measurements of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively") Completed NCT02554422
11 Magnetic Resonance (MR) Imaging in the Post Operative Follow-up of Cholesteatoma in Children Completed NCT00682409
12 Cone Beam CT (CS 9300) for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose Completed NCT01855425
13 Endoscopic Tympanoplasty: Single Versus Double Flap Technique Completed NCT03922295
14 Post Operative Quality of Life Assesment After Patulous Eustachian Tube Surgical Treatment Completed NCT04261946
15 Comprehensive Wide Bandwidth Test Battery of Auditory Function in Veterans Completed NCT02019888
16 Novel Imaging of the Eustachian Tube; Patient Study Completed NCT02282540
17 Diffusion Weighted MRI Accuracy in Cholesteatoma Localization Recruiting NCT03915392
18 The Serum Sclerostin Levels in Cholesteatoma Patients Recruiting NCT03954288
19 Balloon Eustachian Tuboplasty in Treatment of Chronic Eustachian Tube Dysfunction Recruiting NCT03556215
20 Evaluation of Acupuncture Effects for Complications After Surgery of Cerebellopontine Angle Tumor in Skull Base Recruiting NCT04249921
21 Efficacy of Platelet- and Extracellular Vesicle-rich Plasma for the Treatment of Chronically Inflamed Post-surgical Temporal Bone Cavities: a Randomised Controlled Clinical Study Active, not recruiting NCT04281901 Platelet- and extracellular vesicle-rich plasma;Standard conservative treatment
22 Implantation of Trans-tympanic Aerator Using a Robotic Microsurgical Assistance Tool Active, not recruiting NCT03569943
23 Evaluating the Pre-Positioning Frame for Robotic Acoustic Neuroma Removal Surgery Not yet recruiting NCT03057678

Search NIH Clinical Center for Cholesteatoma of Middle Ear

Cochrane evidence based reviews: cholesteatoma

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Genetic Tests for Cholesteatoma of Middle Ear

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Anatomical Context for Cholesteatoma of Middle Ear

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MalaCards organs/tissues related to Cholesteatoma of Middle Ear:

40
Bone, Brain, Skin, Testes, Kidney, Temporal Lobe, Spinal Cord
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Publications for Cholesteatoma of Middle Ear

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Articles related to Cholesteatoma of Middle Ear:

(show top 50) (show all 5590)
# Title Authors PMID Year
1
Cholesteatoma growth and proliferation: posttranscriptional regulation by microRNA-21. 61 46
19672202 2009
2
Comparison of acquired cholesteatoma between pediatric and adult patients. 61 54
19322578 2009
3
Elevated level of tenascin and matrix metalloproteinase 9 correlates with the bone destruction capacity of cholesteatomas. 54 61
19395987 2009
4
[Expression of matrix metalloproteinase-2,9 in cholesteatoma from different positions]. 61 54
19484988 2009
5
Laser-assisted cholesteatoma surgery: technical aspects, in vitro implementation and challenge of selective cell destruction. 61 54
18253741 2008
6
Gelatinolytic activity of matrix metalloproteinases 2 and 9 in middle ear cholesteatoma. 61 54
19128667 2008
7
Topical application of 5-fluorouracil on attic cholesteatoma results in downregulation of keratinocyte growth factor and reduction of proliferative activity. 54 61
18246360 2008
8
Establishment and characterization of an in vitro model for cholesteatoma. 61 54
19434278 2008
9
[The expression of receptor activator nuclear factor-kappaB ligand and osteoprotegerin in cholesteatoma]. 61 54
18589796 2008
10
[Expression and significance of HIF-1alpha and iNOS in human middle ear cholesteatoma epithelium]. 54 61
17650819 2007
11
Survival signaling and terminal differentiation in cholesteatoma epithelium. 54 61
17453465 2007
12
[Expression and significance of nuclear factor-kappa B ligand and correlation factor in the tissue of otitis media with cholesteatoma]. 61 54
17580719 2007
13
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma. 61 54
17419529 2007
14
The localization of matrix metalloproteinases-8 and -13 in cholesteatoma, deep-meatal and post-auricular skin: a comparative analysis. 54 61
17364344 2007
15
The role of tumor necrosis factor-alpha (TNF-alpha) in bone resorption present in middle ear cholesteatoma. 61 54
17505610 2007
16
Comparative cytokeratin distribution patterns in cholesteatoma epithelium. 54 61
17128409 2007
17
The role of S100A1 in external auditory canal cholesteatoma. 54 61
16969478 2006
18
Expression of RANKL and OPG in middle ear cholesteatoma tissue. 61 54
16826057 2006
19
Association between human beta defensin expression and cholesteatoma formation. 54 61
16431059 2006
20
Terminal differentiation and mitogen-activated protein kinase signaling in human cholesteatoma epithelium. 61 54
16639284 2006
21
Characterization of patterns of expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta and their correlations to p53, galectin-3, the retinoic acid receptor-beta and the macrophage migration inhibitory factor (MIF) in human cholesteatomas. 61 54
16513304 2006
22
[Express of transforming growth factor alpha and beta1 in cholesteatoma tissue]. 54 61
16874966 2005
23
Cytokeratin expression pattern in congenital and acquired pediatric cholesteatoma. 61 54
15754169 2005
24
[The expression and significance of human beta-defensin 2 in middle ear cholesteatoma epithelium]. 54 61
16001900 2005
25
[Expression of hypoxia-inducible factor-1alpha in middle ear cholesteatoma]. 61 54
15830692 2005
26
[Detection of the activity of MMP2 and MMP9 in middle ear cholesteatoma]. 61 54
15620146 2004
27
[The expression of matrix metalloproteinase-9 and tumor necrosis factor-alpha in cholesteatoma]. 54 61
15499988 2004
28
[The expressions and correlations of RAR-beta receptors and galectin-8 in human middle ear cholesteatoma]. 61 54
15499989 2004
29
Epidermal growth factor expression in middle ear cholesteatoma. 61 54
15481560 2004
30
Immunohistochemical investigations on external auditory canal cholesteatomas. 61 54
14501442 2003
31
Expression of hypoxia inducible factor 1 alpha and Von Hippel Lindau protein in human middle ear cholesteatoma. 54 61
12838021 2003
32
Gene expression analysis of human middle ear cholesteatoma using complementary DNA arrays. 54 61
12792315 2003
33
Osteoclast stimulating and differentiating factors in human cholesteatoma. 54 61
12616193 2003
34
Expression of beta-defensins in human middle ear cholesteatoma. 61 54
12701748 2003
35
[Possible role of transforming growth factor alpha on the cholesteatoma growth regulation]. 54 61
12725186 2003
36
Possible involvement of keratinocyte growth factor and its receptor in enhanced epithelial-cell proliferation and acquired recurrence of middle-ear cholesteatoma. 54 61
12533693 2003
37
[Expression of transforming growth factor-beta 1 matrix metalloproteinase-1 and its inhibitor in human middle ear cholesteatoma]. 54 61
12768723 2002
38
[The expression of matrix metalloproteinase-1 and interleukin-1-alpha messenger ribonucleic acid in human middle ear cholesteatoma]. 54 61
12768791 2002
39
Up-regulation of matrix metalloprotease-9 in middle ear cholesteatoma--correlations with growth factor expression in vivo? 54 61
11769995 2001
40
The levels of expression of galectin-3, but not of galectin-1 and galectin-8, correlate with apoptosis in human cholesteatomas. 54 61
11404618 2001
41
The levels of retinoid RARbeta receptors correlate with galectin-1, -3 and -8 expression in human cholesteatomas. 61 54
11377877 2001
42
[Expression of matrix metalloproteinasa-2,9 in cholesteatoma and middle ear cancer]. 54 61
12761978 2001
43
Angiogenesis and angiogenic growth factors in middle ear cholesteatoma. 61 54
11078065 2000
44
Acquired and congenital cholesteatoma: determination of tumor necrosis factor-alpha, intercellular adhesion molecule-1, interleukin-1-alpha and lymphocyte functional antigen-1 in the inflammatory process. 54 61
10965261 2000
45
Stromal expression of matrix metalloprotease-9 in middle ear cholesteatomas. 54 61
10993447 2000
46
Induction of matrix metalloproteinases in keratinocytes by cholesteatoma debris and granulation tissue extracts. 54 61
11073191 2000
47
Evaluation of proliferative activity in middle ear cholesteatoma using proliferating cell nuclear antigen. 61 54
10518363 1999
48
Transforming growth factor-alpha and rhinitis. 61 54
10401853 1999
49
Roles of cytokines and cell cycle regulating substances in proliferation of cholesteatoma epithelium. 54 61
10401849 1999
50
Role of Bcl-xL protein in differentiation and apoptosis of human middle ear cholesteatoma epithelium. 54 61
10406309 1999
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Variations for Cholesteatoma of Middle Ear

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Expression for Cholesteatoma of Middle Ear

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Search GEO for disease gene expression data for Cholesteatoma of Middle Ear.
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Pathways for Cholesteatoma of Middle Ear

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Pathways related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.96 TNFSF11 TNFRSF11B S100A8 MMP9 IL1A ICAM1
2
Akt Signaling 63
Show member pathways
 13.33 TNFSF11 TGFA IL1A FGFR2 FGF7 FGF2
3
PAK Pathway 63
Show member pathways
 13.22 TNFSF11 TGFA IL1A FGFR2 FGF7 FGF2
4
Developmental Biology 65
Show member pathways
 13.17 MMP9 KRT16 KRT13 KRT10 IVL FLG
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.13 TNFSF11 TNFRSF11B MMP9 IL1A ICAM1 FGFR2
6
Pathways in cancer 36
12.75 TGFA MMP9 FGFR2 FGF7 FGF2 EGF
7
Ras signaling pathway 36
Show member pathways
 12.66 TGFA FGFR2 FGF7 FGF2 EGF
8
MAPK signaling pathway 36 1
12.65 TGFA IL1A FGFR2 FGF7 FGF2 EGF
9
Gastric cancer 36
Show member pathways
 12.64 TNFSF11 TGFA FGFR2 FGF7 FGF2 EGF
10
Relaxin signaling pathway 36
Show member pathways
 12.59 TGFA MMP9 KRT16 KRT13 KRT10
11
NF-KappaB Family Pathway 63
Show member pathways
 12.53 TGFA IL1A FGFR2 FGF7 FGF2 EGF
12
Glioma 36
Show member pathways
 12.48 TGFA MMP9 FGFR2 FGF7 FGF2 EGF
13
Keratinization 65
Show member pathways
 12.39 KRT16 KRT13 KRT10 IVL FLG
14
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.32 TGFA FGFR2 FGF7 FGF2 EGF
15
RhoGDI Pathway 63
Show member pathways
 12.31 FGFR2 FGF7 FGF2 EGF
16
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.18 TGFA IL1A FGFR2 FGF7 FGF2
17
Tyrosine Kinases / Adaptors 4
12.04 TGFA FGFR2 FGF2 EGF
18
Interleukin-4 and 13 signaling 65
11.88 MMP9 IL1A ICAM1 FGF2
19
Rheumatoid arthritis 36
11.78 TNFSF11 IL1A ICAM1
20
Angiogenesis (CST) 4
11.71 TGFA MMP9 FGFR2 FGF2
21
G-protein signaling_RhoA regulation pathway 22
11.65 TGFA FGFR2 FGF7 FGF2 EGF
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.58 MMP9 IL1A ICAM1
23
Differentiation Pathway 1
11.45 TNFSF11 FGF2 EGF
24
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.41 TNFSF11 TNFRSF11B IL1A
25
Staphylococcus aureus infection 36
11.34 KRT16 KRT13 KRT10 ICAM1 DEFB4A
26
Vemurafenib Pathway, Pharmacodynamics 60
11.09 FGFR2 FGF7 FGF2 EGF
27
Angiogenesis (WikiPathways) 1
11.03 MMP9 FGFR2 FGF2
28
Osteoclast Signaling 1
10.85 TNFSF11 TNFRSF11B
29
Lung fibrosis 1
10.82 TGFA MMP9 FGF7 FGF2 EGF
30
Osteoblast Signaling 1
10.79 TNFSF11 TNFRSF11B
31
G-protein signaling_Rap2B regulation pathway 22
10.77 TNFSF11 TGFA IL1A FGFR2 FGF7 FGF2
Sources

GO Terms for Cholesteatoma of Middle Ear

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Cellular components related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 S100A8 MMP9 MIR21 KRT16 KRT13 KRT10
2 extracellular region GO:0005576 9.73 TNFSF11 TNFRSF11B TGFA S100A8 MMP9 KRT10
3 intermediate filament GO:0005882 9.67 KRT16 KRT13 KRT10 FLG
4 collagen-containing extracellular matrix GO:0062023 9.65 S100A8 MMP9 ICAM1 FLG FGFR2
5 extracellular space GO:0005615 9.47 TNFSF11 TNFRSF11B TGFA S100A8 MMP9 MIRLET7A1
6 cornified envelope GO:0001533 9.33 KRT10 IVL FLG

Biological processes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.99 TGFA MIR21 FGFR2 FGF7 FGF2 EGF
2 angiogenesis GO:0001525 9.92 TGFA FGFR2 FGF2 EGF
3 extracellular matrix organization GO:0030198 9.92 TNFRSF11B MMP9 ICAM1 FGF2
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 MIR21 ICAM1 FGFR2 FGF2
5 cytokine-mediated signaling pathway GO:0019221 9.89 TNFSF11 MMP9 IL1A ICAM1 FGF2
6 MAPK cascade GO:0000165 9.88 TGFA FGFR2 FGF7 FGF2 EGF
7 keratinization GO:0031424 9.87 KRT16 KRT13 KRT10 IVL
8 fibroblast growth factor receptor signaling pathway GO:0008543 9.77 FGFR2 FGF7 FGF2
9 positive regulation of epithelial cell proliferation GO:0050679 9.76 TGFA FGFR2 FGF7
10 positive regulation of MAP kinase activity GO:0043406 9.75 TNFSF11 FGF2 EGF
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.71 MMP9 MIR21 FGF2
12 wound healing GO:0042060 9.71 TGFA S100A8 FGFR2 FGF2
13 positive chemotaxis GO:0050918 9.7 FGF7 FGF2 DEFB4A
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 TGFA ICAM1 FGF7 EGF
15 response to copper ion GO:0046688 9.64 IL1A ICAM1
16 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.64 MIR21 ICAM1
17 positive regulation of keratinocyte proliferation GO:0010838 9.63 MIR21 FGF7
18 positive regulation of epidermal growth factor-activated receptor activity GO:0045741 9.63 TGFA EGF
19 positive regulation of mitotic nuclear division GO:0045840 9.63 TGFA IL1A EGF
20 branching involved in salivary gland morphogenesis GO:0060445 9.61 FGFR2 FGF7
21 positive regulation of keratinocyte migration GO:0051549 9.61 MMP9 FGF7
22 peptide cross-linking GO:0018149 9.61 KRT10 IVL FLG
23 paracrine signaling GO:0038001 9.56 TNFSF11 FGF2
24 keratinocyte differentiation GO:0030216 9.56 KRT16 KRT10 IVL FLG
25 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 9.55 FGFR2 FGF7
26 cornification GO:0070268 9.55 KRT16 KRT13 KRT10 IVL FLG
27 mammary gland alveolus development GO:0060749 9.5 TNFSF11 TGFA EGF
28 positive regulation of cell division GO:0051781 9.35 TGFA IL1A FGFR2 FGF7 FGF2
29 positive regulation of protein kinase B signaling GO:0051897 9.17 TNFSF11 TGFA MIR21 FGFR2 FGF7 FGF2

Molecular functions related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.21 TNFSF11 TNFRSF11B TGFA S100A8 MMP9 LGALS8
2 cytokine activity GO:0005125 9.62 TNFSF11 TNFRSF11B IL1A FGF2
3 structural molecule activity GO:0005198 9.46 KRT16 KRT13 KRT10 FLG
4 structural constituent of epidermis GO:0030280 9.37 KRT10 FLG
5 growth factor activity GO:0008083 9.26 TGFA FGF7 FGF2 EGF
6 chemoattractant activity GO:0042056 8.8 FGF7 FGF2 DEFB4A
Sources

Sources for Cholesteatoma of Middle Ear

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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