MCID: CHL122
MIFTS: 52

Cholesteatoma of Middle Ear

Categories: Ear diseases, Rare diseases, Skin diseases

Aliases & Classifications for Cholesteatoma of Middle Ear

MalaCards integrated aliases for Cholesteatoma of Middle Ear:

Name: Cholesteatoma of Middle Ear 12 15 17
Cholesteatoma 12 54 56 45 15 17 74
Middle Ear Cholesteatoma 12 74
Cholesteatoma of Middle Ear and/or Mastoid 12
Cholesteatoma of Middle Ear and Mastoid 12
Secondary Acquired Cholesteatoma 54
Cholesteatoma of the Middle Ear 12
Primary Acquired Cholesteatoma 54
Epidermosis of Middle Ear 12
Cholesteatoma, Middle Ear 45
Congenital Cholesteatoma 54
Cholesteatoma Middle Ear 56
Epidermosis of Ear 12

Classifications:



Summaries for Cholesteatoma of Middle Ear

NIH Rare Diseases : 54 Cholesteatoma is an abnormal growth of skin in the middle ear behind the eardrum. It can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infections. Individuals with this condition usually experience a painless discharge from the ear.Hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth. Treatment usually involves surgery to remove the growth.

MalaCards based summary : Cholesteatoma of Middle Ear, also known as cholesteatoma, is related to papilloma and rheumatoid arthritis, and has symptoms including earache An important gene associated with Cholesteatoma of Middle Ear is MIR21 (MicroRNA 21), and among its related pathways/superpathways are Akt Signaling and Developmental Biology. Affiliated tissues include bone, skin and brain, and related phenotypes are integument and digestive/alimentary

Disease Ontology : 12 A keratosis characterized by keratinizing squamous epithelium located in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction.

Wikipedia : 77 Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in... more...

Related Diseases for Cholesteatoma of Middle Ear

Diseases related to Cholesteatoma of Middle Ear via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 papilloma 29.3 FLG KRT10 KRT13
2 rheumatoid arthritis 29.0 FLG ICAM1 IL1A MMP9 TNFSF11
3 cholesteatoma of external ear 12.6
4 maxillary sinus cholesteatoma 12.5
5 cholesteatoma of attic 12.3
6 cholesteatoma, congenital 12.2
7 focal labyrinthitis 11.4
8 purulent labyrinthitis 11.1
9 otitis media 10.8
10 suppurative otitis media 10.5
11 chronic purulent otitis media 10.5
12 perilymphatic fistula 10.4
13 bone resorption disease 10.4
14 chronic follicular conjunctivitis 10.4 IL1A MMP9
15 mastoiditis 10.4
16 facial paralysis 10.3
17 villonodular synovitis 10.3 MMP9 TNFSF11
18 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
19 keratosis 10.3
20 tinea corporis 10.2 DEFB4A KRT16
21 meningitis 10.2
22 oral cancer 10.2 KRT13 MIR21 MMP9
23 gingivitis 10.2 DEFB4A IL1A MMP9
24 fibrous dysplasia 10.2
25 labyrinthitis 10.2
26 squamous cell carcinoma 10.2
27 acanthoma 10.2 FGFR2 KRT10
28 steatocystoma multiplex 10.2 KRT10 KRT16
29 pigmented villonodular synovitis 10.2 MMP9 TNFSF11
30 herpes simplex virus keratitis 10.2 ICAM1 LGALS8
31 bowen's disease 10.2 KRT10 KRT16
32 periodontitis 10.2 IL1A MMP9 TNFSF11
33 periodontosis 10.1 MMP9 TNFSF11
34 white sponge nevus 1 10.1 KRT10 KRT13 KRT16
35 anal fistula 10.1 DEFB4A EGF MMP9
36 epidermoid cysts 10.1
37 thrombosis 10.1
38 limbal stem cell deficiency 10.1 ICAM1 IL1A KRT13
39 axenfeld-rieger syndrome, type 3 10.1 EGF TGFA
40 cleft palate, isolated 10.1
41 trigeminal neuralgia 10.1
42 aural atresia, congenital 10.1
43 tympanosclerosis 10.1
44 otitis externa 10.1
45 periodontal disease 10.0 DEFB4A IL1A MMP9 TNFSF11
46 proteasome-associated autoinflammatory syndrome 1 10.0 ICAM1 IL1A MMP9
47 breast adenocarcinoma 10.0 EGF MMP9 TNFSF11
48 langerhans cell histiocytosis 10.0
49 sensorineural hearing loss 10.0
50 histiocytosis 10.0

Comorbidity relations with Cholesteatoma of Middle Ear via Phenotypic Disease Network (PDN):


Otitis Media

Graphical network of the top 20 diseases related to Cholesteatoma of Middle Ear:



Diseases related to Cholesteatoma of Middle Ear

Symptoms & Phenotypes for Cholesteatoma of Middle Ear

UMLS symptoms related to Cholesteatoma of Middle Ear:


earache

MGI Mouse Phenotypes related to Cholesteatoma of Middle Ear:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.86 EGF FGFR2 ICAM1 IL1A KRT16 MMP9
2 digestive/alimentary MP:0005381 9.8 EGF FGFR2 ICAM1 KRT16 MMP9 TGFA
3 muscle MP:0005369 9.63 FGF2 FGFR2 ICAM1 MMP9 TGFA TNFSF11
4 neoplasm MP:0002006 9.43 FGF2 FGFR2 ICAM1 IL1A MMP9 TNFSF11
5 vision/eye MP:0005391 9.17 EGF FGF2 FGFR2 ICAM1 MMP9 TGFA

Drugs & Therapeutics for Cholesteatoma of Middle Ear

Search Clinical Trials , NIH Clinical Center for Cholesteatoma of Middle Ear

Cochrane evidence based reviews: cholesteatoma

Genetic Tests for Cholesteatoma of Middle Ear

Anatomical Context for Cholesteatoma of Middle Ear

MalaCards organs/tissues related to Cholesteatoma of Middle Ear:

42
Bone, Skin, Brain, Kidney, Temporal Lobe, Testes, Endothelial

Publications for Cholesteatoma of Middle Ear

Articles related to Cholesteatoma of Middle Ear:

(show top 50) (show all 2203)
# Title Authors Year
1
Expression of C-type lectin receptor mRNA in otitis media with effusion and chronic otitis media with and without cholesteatoma. ( 30609964 )
2019
2
Intratympanic Membrane Congenital Cholesteatoma Removal Using an Endoscopic System: A Case Report. ( 31056942 )
2019
3
Short-Term Hearing Prognosis of Ossiculoplasty in Pars Flaccida Cholesteatoma Using the EAONO/JOS Staging System. ( 31058592 )
2019
4
Congenital Cholesteatoma of the Mastoid Causing Posterior Semicircular Canal Dehiscence. ( 30531644 )
2019
5
Clinical analysis and nonsurgical management of 11 dogs with aural cholesteatoma. ( 30637895 )
2019
6
Positive perilymph fistula test with semicircular canal dehiscence from cholesteatoma. ( 30692108 )
2019
7
The benefit of trans-attic endoscopic control of ossicular prosthesis after cholesteatoma surgery. ( 30698828 )
2019
8
Is transcanal tympanoplasty an appropriate surgical treatment for congenital middle ear cholesteatoma with ossicular involvement? ( 30554678 )
2019
9
Petrous bone cholesteatoma: our experience of 51 patients with emphasis on cochlea preservation and use of endoscope. ( 31050582 )
2019
10
Improvement of otoendoscopic surgery for epitympanic cholesteatoma invading the mastoid. ( 30987493 )
2019
11
Evaluation of Type III Tympanoplasty Using Cartilage Ossiculoplasty in Cholesteatoma Ear Surgery. ( 30974998 )
2019
12
Facial canal dehiscence in patients with cholesteatoma: concordance between intraoperative inspection, computed tomography and neurophysiological findings. ( 30955064 )
2019
13
The diagnostic accuracy of 1.5 T versus, 3 T non-echo-planar diffusion-weighted imaging in the detection of residual or recurrent cholesteatoma in the middle ear, mastoid. ( 30951771 )
2019
14
Growth and Late Detection of Post-Operative Cholesteatoma on Long Term Follow-Up With Diffusion Weighted Magnetic Resonance Imaging (DWI MRI): A Retrospective Analysis From a Single UK Centre. ( 30939499 )
2019
15
Treatment using diffuse laser energy of cochlear and vestibular fistulas caused by cholesteatoma. ( 30898189 )
2019
16
Measuring growth of residual cholesteatoma in subtotal petrosectomy. ( 30890007 )
2019
17
International Collaborative Assessment of the Validity of the EAONO-JOS Cholesteatoma Staging System. ( 30889114 )
2019
18
Localisation of basic fibroblast growth factor in cholesteatoma matrix: an immunochemical study. ( 30808433 )
2019
19
Identification of residual-recurrent cholesteatoma in operated ears: diagnostic accuracy of dual-energy CT and MRI. ( 30712164 )
2019
20
Spontaneous Resolution of Cholesteatoma in a Patient on Long-Term Infliximab. ( 30632386 )
2019
21
Diffusion-weighted magnetic resonance imaging in the detection of residual and recurrent cholesteatoma in children: A systematic review and meta-analysis. ( 30599286 )
2019
22
Evidence for Oncolytic Viral Eradication of Cholesteatoma In Vitro. ( 30598045 )
2019
23
Nationwide survey of congenital cholesteatoma using staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological Society. ( 30416024 )
2019
24
Canal wall up surgery with mastoid and epitympanic obliteration in acquired cholesteatoma. ( 30408197 )
2019
25
Assessment of Mass Effect Sign at High-Resolution Computed Tomography in Prediction of Cholesteatoma. ( 30407242 )
2019
26
Comparison of the Clinical Results of Attic Cholesteatoma Treatment: Endoscopic Versus Microscopic Ear Surgery. ( 30165729 )
2019
27
Cholesteatoma labyrinthine fistula: prevalence and impact. ( 29599061 )
2019
28
The Genetics of Cholesteatoma Study. Loss-of-function variants in an affected family. ( 31099479 )
2019
29
Canal wall down approach for tympano-mastoid cholesteatoma: long-term results and prognostic factors. ( 31097831 )
2019
30
Effect of CT manifestations of cholesteatoma on MMP-2, MMP-9 and IL-6 in the serum of patients. ( 31086579 )
2019
31
Chemically Assisted Dissection With Sodium 2-Mercaptoethanesulfonate (MESNA) in the Surgical Management of Pediatric Cholesteatoma. ( 31083092 )
2019
32
Growth and Late Detection of Post-Operative Cholesteatoma on Long Term Follow-Up With Diffusion Weighted Magnetic Resonance Imaging (DWI MRI): A Retrospective Analysis From a Single UK Centre. ( 31083089 )
2019
33
International Collaborative Assessment of the Validity of the EAONO-JOS Cholesteatoma Staging System. ( 31083088 )
2019
34
Non-microscopic Middle Ear Cholesteatoma Surgery: A Case Report of a Novel Head-Up Approach. ( 31058751 )
2019
35
Management of Acquired Cholesteatoma Associated With Patulous Eustachian Tube and Habitual Sniffing. ( 31066246 )
2019
36
Does The Type of Ossicular Chain Lesion Affect Outcomes in Chronic Suppurative Otitis Media Without Cholesteatoma? ( 30924779 )
2019
37
Ossicular chain erosion in chronic otitis media patients with cholesteatoma or granulation tissue or without those: analysis of 915 cases. ( 30759279 )
2019
38
The Value of Diffusion-Weighted MRI in the Long-term follow-up After Subtotal Petrosectomy for Extensive Cholesteatoma and Chronic Suppurative Otitis Media. ( 30531639 )
2019
39
Sphenoid Sinus Cholesteatoma-Complications and Skull Base Osteomyelitis: Case Report and Review of Literature. ( 30858746 )
2019
40
Chronic Otitis Media Associated with Cholesteatoma in a Case of the Say-Barber-Biesecker-Young-Simpson Variant of Ohdo Syndrome. ( 30739122 )
2019
41
A case of external auditory canal osteoma complicated with cholesteatoma, mastoiditis, labyrinthitis and internal auditory canal pachymeningitis. ( 30745589 )
2019
42
Bilateral Ear Canal Cholesteatoma with Underlying Type I First Branchial Cleft Anomalies. ( 30607978 )
2019
43
Analysis on outcomes of facial paralysis complicated by middle ear cholesteatoma. ( 30762460 )
2019
44
Middle ear choristoma presenting as cholesteatoma with conductive hearing loss. ( 31044067 )
2019
45
A quantitative study of the suppression of the development of the mastoid air cells by the presence of congenital cholesteatoma. ( 31050578 )
2019
46
Five-year postoperative outcomes of modified staged canal wall up tympanoplasty for primary acquired cholesteatoma. ( 29327305 )
2018
47
Preauricular Approach for Cholesteatoma Resection After Surgical Overclosure of the External Auditory Canal and Cochlear Implantation. ( 29342052 )
2018
48
In reference to Evidence against the mucosal traction theory in cholesteatoma. ( 29392724 )
2018
49
One-Stage Complete Resection of Cholesteatoma With Labyrinthine Fistula: Hearing Changes and Clinical Outcomes. ( 29405738 )
2018
50
Bilateral congenital cholesteatoma: A case report and review of the literature. ( 29501306 )
2018

Variations for Cholesteatoma of Middle Ear

Expression for Cholesteatoma of Middle Ear

Search GEO for disease gene expression data for Cholesteatoma of Middle Ear.

Pathways for Cholesteatoma of Middle Ear

Pathways related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 EGF FGF2 FGFR2 IL1A TGFA TNFSF11
2
Show member pathways
13.22 EGF FGF2 FGFR2 FLG KRT10 KRT13
3
Show member pathways
13.16 EGF FGF2 FGFR2 ICAM1 IL1A MMP9
4
Show member pathways
13.14 EGF FGF2 FGFR2 IL1A TGFA TNFSF11
5
Show member pathways
12.89 KRT10 KRT13 KRT16 MMP9 TGFA
6 12.69 EGF FGF2 FGFR2 MMP9 TGFA
7 12.6 EGF FGF2 FGFR2 IL1A TGFA
8
Show member pathways
12.59 EGF FGF2 FGFR2 TGFA TNFSF11
9
Show member pathways
12.58 EGF FGF2 FGFR2 TGFA
10
Show member pathways
12.54 EGF FGF2 FGFR2 MMP9 TGFA
11
Show member pathways
12.51 EGF FGF2 FGFR2 IL1A TGFA
12
Show member pathways
12.33 FLG KRT10 KRT13 KRT16
13
Show member pathways
12.12 FGF2 FGFR2 IL1A TGFA
14
Show member pathways
12.03 EGF FGF2 FGFR2
15 11.95 ICAM1 IL1A MMP9
16 11.9 EGF FGF2 FGFR2 TGFA
17 11.87 ICAM1 IL1A MMP9
18 11.73 FGF2 ICAM1 IL1A MMP9
19 11.72 ICAM1 IL1A TNFSF11
20 11.58 EGF FGF2 FGFR2 TGFA
21
Show member pathways
11.53 ICAM1 IL1A MMP9
22
Show member pathways
11.48 EGF MMP9 TGFA
23 11.41 FGF2 FGFR2 MMP9 TGFA
24 11.33 EGF FGF2 TNFSF11
25 11.27 EGF FGF2 FGFR2
26
Show member pathways
11.11 EGF FGF2 FGFR2 ICAM1 IL1A TGFA
27 11.06 EGF FGF2 MMP9 TGFA
28 11.04 ICAM1 MMP9
29 10.96 EGF FGF2 FGFR2
30 10.81 FGF2 FGFR2 MMP9
31 10.7 EGF FGF2 FGFR2 IL1A TGFA TNFSF11

GO Terms for Cholesteatoma of Middle Ear

Cellular components related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 EGF ICAM1 KRT10 KRT13 KRT16 MIR21
2 extracellular region GO:0005576 9.61 DEFB4A EGF FGF2 FGFR2 IL1A KRT10
3 intermediate filament GO:0005882 9.46 FLG KRT10 KRT13 KRT16
4 extracellular space GO:0005615 9.36 DEFB4A EGF FGF2 ICAM1 IL1A KRT10

Biological processes related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 EGF FGF2 FGFR2 MIR21 TGFA
2 positive regulation of gene expression GO:0010628 9.92 EGF IL1A MIR21 TNFSF11
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.81 FGF2 FGFR2 ICAM1 MIR21
4 angiogenesis GO:0001525 9.8 EGF FGF2 FGFR2 TGFA
5 positive regulation of angiogenesis GO:0045766 9.79 FGF2 IL1A MIR21
6 animal organ morphogenesis GO:0009887 9.76 FGF2 FGFR2 TNFSF11
7 activation of MAPK activity GO:0000187 9.75 EGF FGF2 TGFA
8 wound healing GO:0042060 9.74 FGF2 FGFR2 TGFA
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.73 EGF ICAM1 TGFA
10 cytokine-mediated signaling pathway GO:0019221 9.72 FGF2 ICAM1 IL1A MMP9 TNFSF11
11 keratinocyte differentiation GO:0030216 9.7 FLG KRT10 KRT16
12 positive regulation of MAP kinase activity GO:0043406 9.63 EGF FGF2 TNFSF11
13 ERK1 and ERK2 cascade GO:0070371 9.62 EGF TNFSF11
14 positive regulation of vascular endothelial cell proliferation GO:1905564 9.61 FGF2 MIR21
15 establishment of skin barrier GO:0061436 9.6 FLG KRT16
16 response to copper ion GO:0046688 9.59 ICAM1 IL1A
17 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.58 FGF2 MIR21 MMP9
18 cornification GO:0070268 9.56 FLG KRT10 KRT13 KRT16
19 positive regulation of epidermal growth factor-activated receptor activity GO:0045741 9.55 EGF TGFA
20 positive regulation of mitotic nuclear division GO:0045840 9.54 EGF IL1A TGFA
21 paracrine signaling GO:0038001 9.48 FGF2 TNFSF11
22 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.43 ICAM1 MIR21
23 positive regulation of protein kinase B signaling GO:0051897 9.35 EGF FGF2 FGFR2 MIR21 TNFSF11
24 mammary gland alveolus development GO:0060749 9.33 EGF TGFA TNFSF11
25 positive regulation of cell division GO:0051781 8.92 FGF2 FGFR2 IL1A TGFA

Molecular functions related to Cholesteatoma of Middle Ear according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.54 EGF FGF2 TGFA
2 integrin binding GO:0005178 9.43 FGF2 ICAM1 LGALS8
3 protein tyrosine kinase activity GO:0004713 9.02 FGFR2
4 structural constituent of epidermis GO:0030280 8.96 FLG KRT10
5 structural molecule activity GO:0005198 8.92 FLG KRT10 KRT13 KRT16
6 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.85 EGF
7 protein binding GO:0005515 10.22 DEFB4A EGF FGF2 FGFR2 FLG ICAM1

Sources for Cholesteatoma of Middle Ear

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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