Cholesteatoma of Middle Ear

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Disease Ontology 12 DOID:10964 DOID:869 ICD10 33 H71 H71.9 H71.90 ICD9CM 35 385.3 385.32 385.33 385.30 more MeSH 44 D018424 D002781

NCIt 50 C3654 C2944 SNOMED-CT 68 194339007 194340009 360584008 39911004 87688009 155244001 194338004 267766007 363668000 575006 more UMLS 73 C0008374 C0155490 C0008373

NIH Rare Diseases : ⁵³ Cholesteatoma is an abnormal growth of skin in the middle ear behind the eardrum. It can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infections. Individuals with this condition usually experience a painless discharge from the ear.Hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth. Treatment usually involves surgery to remove the growth.

MalaCards based summary : Cholesteatoma of Middle Ear, also known as cholesteatoma, is related to papilloma and orofacial cleft, and has symptoms including earache An important gene associated with Cholesteatoma of Middle Ear is MIR21 (MicroRNA 21
Among the microRNAs investigated, human microRNA-21 (hsa-miR-21) showed a 4.4-fold higher expression in cholesteatoma as compared with normal skin (p = 0.0011). The downstream targets of hsa-miR-21, PTEN and programmed cell death 4, were found to be greatly reduced in 3 of 4 cholesteatoma samples. Proposed upstream regulators of hsa-miR-21 expression (CD14, interleukin 6R, gp130, and signal transducer and activator of transcription 3) were present in all cholesteatoma tissues. CONCLUSION:: MicroRNAs represent powerful regulators of protein translation, and their dysregulation has been implicated in many neoplastic diseases. This study specifically identified up-regulation of hsa-miR-21 concurrent with down-regulation of potent tumor suppressor proteins PTEN and programmed cell death 4. These proteins control aspects of apoptosis, proliferation, invasion, and migration. The results of this study were used to develop a model for cholesteatoma proliferation through microRNA dysregulation. This model can serve as a template for further study into potential RNA-based therapies for the treatment of cholesteatoma.), and among its related pathways/superpathways are Akt Signaling and Developmental Biology. Affiliated tissues include skin, brain and bone, and related phenotypes are integument and digestive/alimentary

Wikipedia : ⁷⁶ Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in... more...

Search Clinical Trials , NIH Clinical Center for Cholesteatoma of Middle Ear

Search GEO for disease gene expression data for Cholesteatoma of Middle Ear.