MCID: CHL070
MIFTS: 33

Cholesterol Embolism

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Cholesterol Embolism

MalaCards integrated aliases for Cholesterol Embolism:

Name: Cholesterol Embolism 12 15 17 74
Trash Foot 12 74
Cholesterol Crystal Embolism 12
Cholesterol Embolus Syndrome 74
Warfarin Blue Toe Syndrome 12
Embolism, Cholesterol 45
Purple Toe Syndrome 12
Atheroembolism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1461
ICD9CM 36 445
MeSH 45 D017700
SNOMED-CT 69 10690002
ICD10 34 I75

Summaries for Cholesterol Embolism

Disease Ontology : 12 A vascular disease that is characterized by blood vessel obstruction resulting from the release of cholesterol from the inside of blood vessels along the bloodstream.

MalaCards based summary : Cholesterol Embolism, also known as trash foot, is related to peripheral vascular disease and carotid stenosis. An important gene associated with Cholesterol Embolism is RBMS2 (RNA Binding Motif Single Stranded Interacting Protein 2). The drugs Prednisone and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and bone.

Wikipedia : 77 Cholesterol embolism occurs when cholesterol is released, usually from an atherosclerotic plaque, and... more...

Related Diseases for Cholesterol Embolism

Diseases related to Cholesterol Embolism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 peripheral vascular disease 29.7 ACE CRP
2 carotid stenosis 29.6 ACE CRP
3 arteriosclerosis 29.6 ACE CRP
4 interstitial nephritis 29.4 ACE CRP
5 acute myocardial infarction 29.1 ACE CRP
6 chronic kidney failure 29.1 ACE CRP
7 atheroembolism of kidney 12.1
8 hypereosinophilic syndrome 10.1
9 intracranial embolism 10.1 GIPC1 TAX1BP3
10 amegakaryocytic thrombocytopenia, congenital 10.1 GIPC1 TAX1BP3
11 congenital cystic eye 10.1
12 renal cell carcinoma, nonpapillary 9.9
13 systemic lupus erythematosus 9.9
14 focal segmental glomerulosclerosis 1 9.9
15 myelodysplastic syndrome 9.9
16 membranous nephropathy 9.9
17 focal segmental glomerulosclerosis 9.9
18 limb ischemia 9.9
19 colitis 9.9
20 clostridium difficile colitis 9.9
21 nephrotic syndrome 9.9
22 vascular disease 9.9
23 antiphospholipid syndrome 9.9
24 ischemia 9.9
25 lupus erythematosus 9.9
26 chromosomal triplication 9.9
27 generalized atherosclerosis 9.9 ACE CRP
28 ischemic heart disease 9.9 ACE CRP
29 subdural empyema 9.9 ACE CRP
30 hypersensitivity vasculitis 9.9 ACE CRP
31 granulomatous angiitis 9.9 ACE CRP
32 intermediate coronary syndrome 9.9 ACE CRP
33 myositis 9.9
34 protein-losing enteropathy 9.9
35 leiomyoma 9.9
36 polyneuropathy 9.9
37 kidney disease 9.9
38 paraplegia 9.9
39 ischemic fasciitis 9.9
40 focal myositis 9.9
41 systolic heart failure 9.9 ACE CRP
42 arteritic anterior ischemic optic neuropathy 9.9 ACE CRP
43 angina pectoris 9.9 ACE CRP
44 extrinsic cardiomyopathy 9.9 ACE CRP
45 intermittent claudication 9.9 ACE CRP
46 peripheral artery disease 9.9 ACE CRP
47 pyelonephritis 9.9 ACE CRP
48 heart conduction disease 9.9 ACE CRP
49 heart valve disease 9.9 ACE CRP
50 coronary stenosis 9.9 ACE CRP

Graphical network of the top 20 diseases related to Cholesterol Embolism:



Diseases related to Cholesterol Embolism

Symptoms & Phenotypes for Cholesterol Embolism

Drugs & Therapeutics for Cholesterol Embolism

Drugs for Cholesterol Embolism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
2 Anti-Inflammatory Agents Phase 2
3 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
4 Hormones Phase 2
5 Antineoplastic Agents, Hormonal Phase 2
6 Hormone Antagonists Phase 2
7 glucocorticoids Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Renal Stenting With Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
2 Clinical Study to Evaluate the Efficacy of Blood Purification Therapy on Cholesterol Crystal Embolism Recruiting NCT01726868 Phase 2
3 Efficacy of Prednisone in Patients With Severe Systemic Atheroembolism (Cholesterol Cristal Embolism) Terminated NCT01452100 Phase 2 prednisone
4 MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery Completed NCT00027469 Phase 1
5 A Maastricht Contrast-Induced Nephropathy Guidelines Study: CIN Prevention Guidelines: Appropriate & Cost-effective? Completed NCT02106234 Not Applicable

Search NIH Clinical Center for Cholesterol Embolism

Cochrane evidence based reviews: embolism, cholesterol

Genetic Tests for Cholesterol Embolism

Anatomical Context for Cholesterol Embolism

MalaCards organs/tissues related to Cholesterol Embolism:

42
Skin, Kidney, Bone, Bone Marrow, Colon, Eye, Retina

Publications for Cholesterol Embolism

Articles related to Cholesterol Embolism:

(show top 50) (show all 88)
# Title Authors Year
1
The Cholesterol Embolism Syndrome. ( 28446355 )
2017
2
Cholesterol embolism: it's always a good idea to look into the eye. ( 28939621 )
2017
3
Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review. ( 27446313 )
2016
4
Late Onset of Cholesterol Embolism Leading to Graft Failure After Renal Transplantation: Report of Two Cases. ( 26518927 )
2015
5
Intestinal cholesterol embolism resulting from intra-aortic balloon pumping: a case report. ( 24951057 )
2014
6
Transbrachial carotid artery stenting can prevent renal cholesterol embolism. ( 24785896 )
2014
7
Millipede burn masquerading as trash foot in a paediatric patient. ( 24168263 )
2014
8
Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease. ( 24163269 )
2013
9
An autopsy case of idiopathic cholesterol embolism. ( 23224026 )
2013
10
Facial livedo racemosa as a warning sign of cholesterol embolism from atherosclerotic plaques of the carotid artery. ( 21571195 )
2011
11
Spontaneous cutaneous cholesterol embolism. ( 19744823 )
2010
12
Cholesterol embolism associated with MPO-ANCA. ( 20409998 )
2010
13
Cutaneous reactive angiomatosis associated with cholesterol embolism. ( 19614996 )
2010
14
Post-coronary stenting renal cholesterol embolism treated by renal artery stenting. ( 19819797 )
2009
15
Segmental testicular infarction due to cholesterol embolism: not the first case, but the first report. ( 18844943 )
2008
16
Cholesterol embolism evaluated by polarized light microscopy after primary renal artery stent placement with filter protection. ( 18341947 )
2008
17
Facial cutaneous cholesterol embolism revealing a tight carotid stenosis: a case report. ( 17067829 )
2007
18
Reversible encephalopathy associated with cholesterol embolism syndrome: magnetic resonance imaging and pathological findings. ( 17229746 )
2007
19
Steroid-responsive leucoencephalopathy due to cholesterol embolism. ( 17229741 )
2007
20
Cholesterol embolism after colonoscopy: a case report. ( 16564892 )
2006
21
A case of cholesterol embolism confirmed by skin biopsy and successfully treated with statins and steroids. ( 16702800 )
2006
22
LDL apheresis for cholesterol embolism following coronary artery bypass graft surgery--a case report. ( 16703200 )
2006
23
Cholesterol embolism: still an unrecognized entity with a high mortality rate. ( 17052483 )
2006
24
Renal cholesterol embolism: analysis of two spontaneous autopsy cases. ( 15705188 )
2005
25
Cholesterol embolism after cardiac catheterization mimicking infective endocarditis. ( 16293917 )
2005
26
The importance of skin biopsy in the diverse clinical manifestations of cholesterol embolism. ( 15214931 )
2004
27
Renal cholesterol embolism in patients with carotid stenosis: a severe and underdiagnosed complication following cerebrovascular procedures. ( 15240205 )
2004
28
Contrast medium-induced acute renal failure and cholesterol embolism after radiological procedures: incidence, risk factors, and compliance with recommendations. ( 14614975 )
2003
29
Efficiency of colchicine and corticosteroids in a leg ulceration with cholesterol embolism in a woman with rheumatoid arthritis. ( 12869676 )
2003
30
An unusual rash. Cholesterol embolism. ( 12741394 )
2003
31
Intravascular cholesterol clefts as an incidental finding: cholesterol embolism or not? ( 14631193 )
2003
32
Temporary spinal cord stimulation for peripheral cholesterol embolism. ( 11887066 )
2002
33
Cholesterol embolism: an often unrecognized cause of leg ulcers. ( 12072093 )
2002
34
Small dose oral corticosteroid treatment rapidly improved renal function in a patient with an acute aggravation of chronic renal failure due to cholesterol embolism. ( 11274298 )
2001
35
Potential therapeutic effect of simvastatin on progressive renal failure and nephrotic-range proteinuria caused by renal cholesterol embolism. ( 11465248 )
2001
36
Renal transplantation in a patient with end stage renal disease due to cholesterol embolism. ( 11211182 )
2001
37
Cholesterol embolism: a case report and review of the literature. ( 11710445 )
2001
38
Disseminated cholesterol embolism after coronary artery bypass grafting. ( 11885774 )
2001
39
A case of cholesterol embolism with ANCA treated with corticosteroid and cyclophosphamide. ( 11436867 )
2001
40
Cholesterol embolism causing delayed healing of a foot ulcer. ( 11465249 )
2001
41
Cholesterol embolism as a complication of aortic dissection. ( 10477543 )
1999
42
Delayed appearance of livedo reticularis in 3 cases with a cholesterol embolism. ( 10376714 )
1999
43
Cholesterol embolism associated with macroscopic renal infarction. ( 10328481 )
1999
44
Cholesterol embolism in a patient with inflammatory abdominal aortic aneurysm. ( 10563746 )
1999
45
Recurrent renal cholesterol embolism. ( 10692886 )
1999
46
LDL apheresis as intensive lipid-lowering therapy for cholesterol embolism. ( 10328511 )
1999
47
Cholesterol embolism: a fatal complication after thrombolytic therapy for acute myocardial infarction. ( 9679800 )
1998
48
Cholesterol embolism and acute interstitial nephritis: two adverse effects of streptokinase thrombolytic therapy in the same patient. ( 9623565 )
1998
49
Investigation of the thoracic aorta in cholesterol embolism by transoesophageal echocardiography. ( 9538304 )
1998
50
Post-arteriography cholesterol embolism. ( 9771786 )
1998

Variations for Cholesterol Embolism

Expression for Cholesterol Embolism

Search GEO for disease gene expression data for Cholesterol Embolism.

Pathways for Cholesterol Embolism

GO Terms for Cholesterol Embolism

Sources for Cholesterol Embolism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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