MCID: CHL070
MIFTS: 37

Cholesterol Embolism

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Cholesterol Embolism

MalaCards integrated aliases for Cholesterol Embolism:

Name: Cholesterol Embolism 12 15 17 71
Trash Foot 12 71
Cholesterol Crystal Embolism 12
Cholesterol Embolus Syndrome 71
Warfarin Blue Toe Syndrome 12
Embolism, Cholesterol 43
Purple Toe Syndrome 12
Atheroembolism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1461
ICD9CM 34 445
MeSH 43 D017700
SNOMED-CT 67 10690002
ICD10 32 I75
UMLS 71 C0149649 C0264980 C0585266

Summaries for Cholesterol Embolism

Disease Ontology : 12 A vascular disease that is characterized by blood vessel obstruction resulting from the release of cholesterol from the inside of blood vessels along the bloodstream.

MalaCards based summary : Cholesterol Embolism, also known as trash foot, is related to aortic disease and acalculous cholecystitis. An important gene associated with Cholesterol Embolism is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and heart.

Wikipedia : 74 Cholesterol embolism occurs when cholesterol is released, usually from an atherosclerotic plaque, and... more...

Related Diseases for Cholesterol Embolism

Diseases related to Cholesterol Embolism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 344)
# Related Disease Score Top Affiliating Genes
1 aortic disease 30.9 REN CRP ACE
2 acalculous cholecystitis 30.7 F2 CRP
3 silent myocardial infarction 30.6 CRP ACE
4 active peptic ulcer disease 30.5 F2 CRP
5 uremia 30.5 REN CRP ACE
6 blue toe syndrome 30.4 SERPINC1 F2 CRP
7 carotid stenosis 30.4 REN CRP ACE
8 aortic aneurysm, familial abdominal, 1 30.4 PLG CRP ACE
9 hypersensitivity vasculitis 30.4 CRP ACE
10 generalized atherosclerosis 30.3 REN CRP ACE
11 acute kidney failure 30.3 REN HAVCR1 F2
12 end stage renal failure 30.3 REN CRP ACE
13 spinal cord infarction 30.2 SERPINC1 F2
14 exanthem 30.2 F2 CRP ACE
15 congestive heart failure 30.1 REN CRP ACE
16 retinal vascular disease 29.9 REN PLG CRP ACE
17 antiphospholipid syndrome 29.9 SERPINC1 F2 CRP
18 purpura 29.8 SERPINC1 F2 CRP ACE
19 acute kidney tubular necrosis 29.8 REN HAVCR1 ACE
20 heart valve disease 29.7 REN F2 CRP ACE
21 osteonecrosis 29.7 SERPINC1 PLG F2
22 cerebrovascular disease 29.7 REN F2 CRP ACE
23 respiratory failure 29.6 REN F2 CRP ACE
24 arteries, anomalies of 29.6 REN PLG CRP ACE
25 endocarditis 29.6 SERPINC1 F2 CRP
26 splenic infarction 29.6 SERPINC1 F2 CRP
27 acute myocardial infarction 29.6 SERPINC1 REN PLG CRP ACE
28 ischemic colitis 29.6 SERPINC1 F2 CRP ACE
29 intermittent claudication 29.5 SERPINC1 F2 CRP ACE
30 pulmonary embolism 29.5 SERPINC1 F2 CRP ACE
31 disseminated intravascular coagulation 29.5 SERPINC1 PLG F2 CRP
32 compartment syndrome 29.5 SERPINC1 PLG F2 CRP
33 arteriosclerosis 29.4 SERPINC1 CRP ACE
34 interstitial nephritis 29.4 REN HAVCR1 CRP ACE
35 peripheral vascular disease 29.3 SERPINC1 F2 CRP ACE
36 intracranial embolism 29.2 SERPINC1 PLG F2 CRP ACE
37 pulmonary edema 29.0 SERPINC1 REN F2 CRP ACE
38 intermediate coronary syndrome 29.0 SERPINC1 REN PLG CRP ACE
39 chronic kidney disease 28.9 REN HAVCR1 CYP2C9 CRP ACE
40 coronary artery anomaly 28.9 SERPINC1 PLG F2 CRP ACE
41 stroke, ischemic 28.9 SERPINC1 REN PLG F2 CRP ACE
42 myocardial infarction 28.4 SERPINC1 REN PLG F2 CYP2C9 CRP
43 vascular disease 28.3 SERPINC1 REN PLG F2 CYP2C9 CRP
44 atheroembolism of kidney 12.2
45 mediastinum teratoma 10.5 CRP ACE
46 acute dacryoadenitis 10.5 CRP ACE
47 pyeloureteritis cystica 10.5 REN CRP
48 hypoaldosteronism 10.5 REN ACE
49 chronic orbital inflammation 10.5 CRP ACE
50 renal artery obstruction 10.5 REN ACE

Graphical network of the top 20 diseases related to Cholesterol Embolism:



Diseases related to Cholesterol Embolism

Symptoms & Phenotypes for Cholesterol Embolism

Drugs & Therapeutics for Cholesterol Embolism

Drugs for Cholesterol Embolism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
2
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
3
Ticagrelor Approved Phase 3 274693-27-5 9871419
4 Neurotransmitter Agents Phase 3
5 Anti-Inflammatory Agents Phase 3
6 Fibrinolytic Agents Phase 3
7 Antipyretics Phase 3
8 Anti-Inflammatory Agents, Non-Steroidal Phase 3
9 Analgesics, Non-Narcotic Phase 3
10 Platelet Aggregation Inhibitors Phase 3
11 Cyclooxygenase Inhibitors Phase 3
12 Antirheumatic Agents Phase 3
13 Analgesics Phase 3
14 Purinergic P2Y Receptor Antagonists Phase 3
15
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
16
Methamphetamine Approved, Illicit Phase 2 537-46-2 10836
17
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
18 Sympathomimetics Phase 2
19 Dopamine Uptake Inhibitors Phase 2
20 Central Nervous System Stimulants Phase 2
21 Dopamine Agents Phase 2
22 Autonomic Agents Phase 2
23 Adrenergic Agents Phase 2
24 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
25 Hormone Antagonists Phase 2
26 Antineoplastic Agents, Hormonal Phase 2
27 glucocorticoids Phase 2
28 Hormones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Percutaneous Renal Stenting in Renovascular Disease With or Without Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
2 A Prospective, Multicentre, Randomized, Open Label, Blinded Endpoint, Phase 3 Trial to Assess the Safety and Efficacy of Prophylactic TicagrelOr With Acetylsalicylic Acid Versus CLopidogrel With Acetylsalicylic Acid in the Development of Cerebrovascular EMbolic Events During Transcatheter Aortic Valve Implantation (TAVI) OperationS - the PTOLEMAIOS Study. Unknown status NCT02989558 Phase 3 Ticagrelor plus ASA;Clopidogrel plus ASA
3 Surgical Manipulation of the Ascending Aorta and Cerebral Infarction Following CABG Unknown status NCT00558779 Phase 2
4 Clinical Study to Evaluate the Efficacy of Blood Purification Therapy on Cholesterol Crystal Embolism Recruiting NCT01726868 Phase 2
5 Efficacy of Prednisone in Patients With Severe Systemic Atheroembolism (Cholesterol Cristal Embolism) Terminated NCT01452100 Phase 2 prednisone
6 Evidence of Procedural Embolism Complicating Renal Artery Stenting Completed NCT00027469 Phase 1
7 Randomised Controlled Trial Evaluating Prophylactic Intravenous Hydration for the Prevention of Contrast Induced Nephropathy Completed NCT02106234

Search NIH Clinical Center for Cholesterol Embolism

Cochrane evidence based reviews: embolism, cholesterol

Genetic Tests for Cholesterol Embolism

Anatomical Context for Cholesterol Embolism

MalaCards organs/tissues related to Cholesterol Embolism:

40
Kidney, Skin, Heart, Bone, Small Intestine, Bone Marrow, Colon

Publications for Cholesterol Embolism

Articles related to Cholesterol Embolism:

(show top 50) (show all 240)
# Title Authors PMID Year
1
Stent-Assisted Angioplasty (SAA) at the Level of the Common Femoral Artery Bifurcation: Long-Term Outcomes. 61
31974742 2020
2
Carpal arch cholesterol embolism. 61
31387446 2020
3
[Prevention of "contrast-induced" acute kidney injury - practical considerations]. 61
31350739 2019
4
Acute Renal Failure of Nosocomial Origin. 61
30961801 2019
5
Slender transradial iliac artery stenting using a 4.5 French guiding sheath. 61
29305825 2019
6
Midterm Outcomes of Endovascular Aortic Aneurysm Repair with Carbon Dioxide-Guided Angiography. 61
29772311 2018
7
Novel Insights into Crystal-Induced Kidney Injury. 61
29998119 2018
8
Cholesterol embolism: it's always a good idea to look into the eye. 61
28939621 2017
9
The Cholesterol Embolism Syndrome. 61
28446355 2017
10
Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review. 61
27446313 2016
11
Late Onset of Cholesterol Embolism Leading to Graft Failure After Renal Transplantation: Report of Two Cases. 61
26518927 2015
12
Intestinal cholesterol embolism resulting from intra-aortic balloon pumping: a case report. 61
24951057 2014
13
Millipede burn masquerading as trash foot in a paediatric patient. 61
24168263 2014
14
Atherosclerosis associated with vasculopathic lesions in a golden retriever with hypercholesterolemia. 61
24790237 2014
15
Clinical Neuropathology practice guide 3-2014: combined nerve and muscle biopsy in the diagnostic workup of neuropathy - the Bordeaux experience. 61
24618073 2014
16
Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease. 61
24163269 2014
17
Transbrachial carotid artery stenting can prevent renal cholesterol embolism. 61
24785896 2014
18
Initial results of transradial iliac artery stenting. 61
24203346 2014
19
[Foot lesions]. 61
24114468 2013
20
An autopsy case of idiopathic cholesterol embolism. 61
23224026 2013
21
613 cases of splenic rupture without risk factors or previously diagnosed disease: a systematic review. 61
22889306 2012
22
[Atheroembolism renal disease: diagnosis and etiologic factors]. 61
23007816 2012
23
Pitfall in nephrology: contrast nephropathy has to be differentiated from renal damage due to atheroembolic disease. 61
22419233 2012
24
[Cholesterol embolism syndrome: a rare, but severe complication in patients with atherosclerosis]. 61
22588660 2012
25
Multiple renal infarctions due to thromboembolism. Importance of ultrasound in diagnosis. Case report. 61
22396944 2012
26
[Case of purpura nephritis accompanied by idiopathic cholesterol embolism]. 61
22991843 2012
27
Facial livedo racemosa as a warning sign of cholesterol embolism from atherosclerotic plaques of the carotid artery. 61
21571195 2011
28
Marked regression of aortic plaque by intensive cholesterol-lowering therapy. 61
21242651 2011
29
Cholesterol embolism associated with MPO-ANCA. 61
20409998 2010
30
Spontaneous cutaneous cholesterol embolism. 61
19744823 2010
31
Filters placed in the superficial femoral arteries for limb salvage in a high-surgical-risk patient with atheroembolism: results at 2 years. 61
20557183 2010
32
Cutaneous reactive angiomatosis associated with cholesterol embolism. 61
19614996 2010
33
[Atheroembolic renal disease: analysis of clinical and therapeutic factors that influence its progression]. 61
20414329 2010
34
[Penile calciphylaxis: 5-year experience and literature review]. 61
19925764 2009
35
Post-coronary stenting renal cholesterol embolism treated by renal artery stenting. 61
19819797 2009
36
Stent placement in patients with atherosclerotic renal artery stenosis and impaired renal function: a randomized trial. 61
19414832 2009
37
[French 2008 guidelines on peritoneal dialysis: indications and non-indications]. 61
19596349 2009
38
Segmental testicular infarction due to cholesterol embolism: not the first case, but the first report. 61
18844943 2008
39
Aortic thrombus due to essential thrombocytosis: strategies for medical and surgical management. 61
18513483 2008
40
Catastrophic cholesterol crystal embolization after endovascular stent placement for peripheral vascular disease. 61
18480661 2008
41
[Cholesterol embolism causing ischemic colitis]. 61
18662086 2008
42
Cholesterol embolism evaluated by polarized light microscopy after primary renal artery stent placement with filter protection. 61
18341947 2008
43
[Acute renal failure caused by cholesterol embolism of the intrarenal arteries after coronaroangiography: success of glucocorticosteroid treatment]. 61
18807542 2008
44
[Spontaneous cholesterol embolism confused with peripheral arterial disease]. 61
18065361 2007
45
[Blue toe syndrome; a sign of end-arterial occlusion]. 61
17624153 2007
46
Non-neoplastic renal diseases in Kerala, India--analysis of 1592 cases, a two year retrospective study. 61
17883050 2007
47
Steroid-responsive leucoencephalopathy due to cholesterol embolism. 61
17229741 2007
48
Reversible encephalopathy associated with cholesterol embolism syndrome: magnetic resonance imaging and pathological findings. 61
17229746 2007
49
Facial cutaneous cholesterol embolism revealing a tight carotid stenosis: a case report. 61
17067829 2007
50
Cholesterol embolism: still an unrecognized entity with a high mortality rate. 61
17052483 2006

Variations for Cholesterol Embolism

Expression for Cholesterol Embolism

Search GEO for disease gene expression data for Cholesterol Embolism.

Pathways for Cholesterol Embolism

GO Terms for Cholesterol Embolism

Cellular components related to Cholesterol Embolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 SERPINC1 PLG F2

Biological processes related to Cholesterol Embolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibrinolysis GO:0042730 9.37 PLG F2
2 amyloid-beta metabolic process GO:0050435 9.32 REN ACE
3 regulation of blood coagulation GO:0030193 9.26 SERPINC1 F2
4 angiotensin maturation GO:0002003 9.16 REN ACE
5 negative regulation of fibrinolysis GO:0051918 8.96 PLG F2
6 hemostasis GO:0007599 8.8 SERPINC1 PLG F2

Molecular functions related to Cholesterol Embolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.8 REN PLG ACE

Sources for Cholesterol Embolism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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