MCID: CHL070
MIFTS: 32

Cholesterol Embolism

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Cholesterol Embolism

MalaCards integrated aliases for Cholesterol Embolism:

Name: Cholesterol Embolism 12 15 17 72
Trash Foot 12 72
Cholesterol Crystal Embolism 12
Cholesterol Embolus Syndrome 72
Warfarin Blue Toe Syndrome 12
Embolism, Cholesterol 44
Purple Toe Syndrome 12
Atheroembolism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1461
ICD9CM 35 445
MeSH 44 D017700
SNOMED-CT 68 10690002
ICD10 33 I75
UMLS 72 C0149649 C0264980 C0585266

Summaries for Cholesterol Embolism

Disease Ontology : 12 A vascular disease that is characterized by blood vessel obstruction resulting from the release of cholesterol from the inside of blood vessels along the bloodstream.

MalaCards based summary : Cholesterol Embolism, also known as trash foot, is related to intracranial embolism and atheroembolism of kidney. An important gene associated with Cholesterol Embolism is RBMS2 (RNA Binding Motif Single Stranded Interacting Protein 2). The drugs Ticagrelor and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and colon.

Wikipedia : 75 Cholesterol embolism occurs when cholesterol is released, usually from an atherosclerotic plaque, and... more...

Related Diseases for Cholesterol Embolism

Diseases related to Cholesterol Embolism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 intracranial embolism 29.4 TAX1BP3 GIPC1
2 atheroembolism of kidney 12.2
3 kidney disease 10.5
4 acute kidney failure 10.4
5 hypereosinophilic syndrome 10.4
6 cholecystitis 10.3
7 aortic disease 10.3
8 blue toe syndrome 10.3
9 vasculitis 10.2
10 acute myocardial infarction 10.2
11 myocardial infarction 10.2
12 aortic aneurysm 10.1
13 renal cell carcinoma, nonpapillary 10.1
14 membranous nephropathy 10.1
15 nephrotic syndrome 10.1
16 intestinal perforation 10.1
17 acalculous cholecystitis 10.1
18 ileus 10.1
19 aortic aneurysm, familial abdominal, 1 10.0
20 purpura 10.0
21 uremia 10.0
22 chronic kidney disease 10.0
23 stroke, ischemic 10.0
24 atherosclerosis susceptibility 10.0
25 cyanosis, transient neonatal 10.0
26 carotid stenosis 10.0
27 vascular disease 10.0
28 arteriosclerosis 10.0
29 end stage renal failure 10.0
30 polyarteritis nodosa 10.0
31 aneurysm 10.0
32 spinal cord infarction 10.0
33 hand skill, relative 10.0
34 hypercholesterolemia, familial, 1 10.0
35 systemic lupus erythematosus 10.0
36 myelodysplastic syndrome 10.0
37 limb ischemia 10.0
38 clostridium difficile colitis 10.0
39 cardiac arrest 10.0
40 hemiplegia 10.0
41 disseminated intravascular coagulation 10.0
42 nephrosclerosis 10.0
43 acute kidney tubular necrosis 10.0
44 focal segmental glomerulosclerosis 10.0
45 thrombocytopenia 10.0
46 impotence 10.0
47 antiphospholipid syndrome 10.0
48 subacute bacterial endocarditis 10.0
49 rapidly progressive glomerulonephritis 10.0
50 congestive heart failure 10.0

Graphical network of the top 20 diseases related to Cholesterol Embolism:



Diseases related to Cholesterol Embolism

Symptoms & Phenotypes for Cholesterol Embolism

Drugs & Therapeutics for Cholesterol Embolism

Drugs for Cholesterol Embolism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticagrelor Approved Phase 3 274693-27-5 9871419
2
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4 Neurotransmitter Agents Phase 3
5 Peripheral Nervous System Agents Phase 3
6 Anti-Inflammatory Agents Phase 3
7 Cyclooxygenase Inhibitors Phase 3
8 Analgesics, Non-Narcotic Phase 3
9 Fibrinolytic Agents Phase 3
10 Purinergic P2Y Receptor Antagonists Phase 3
11 Purinergic P2 Receptor Antagonists Phase 3
12 Analgesics Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 3
14 Platelet Aggregation Inhibitors Phase 3
15 Antipyretics Phase 3
16 Antirheumatic Agents Phase 3
17
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
18
Methamphetamine Approved, Illicit Phase 2 537-46-2 10836
19
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
20 Sympathomimetics Phase 2
21 Central Nervous System Stimulants Phase 2
22 Adrenergic Agents Phase 2
23 Dopamine Agents Phase 2
24 Neurotransmitter Uptake Inhibitors Phase 2
25 Dopamine Uptake Inhibitors Phase 2
26 Autonomic Agents Phase 2
27 Hormones Phase 2
28 glucocorticoids Phase 2
29 Antineoplastic Agents, Hormonal Phase 2
30 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
31 Hormone Antagonists Phase 2
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Percutaneous Renal Stenting in Renovascular Disease With or Without Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
2 A Prospective, Multicentre, Randomized, Open Label, Blinded Endpoint, Phase 3 Trial to Assess the Safety and Efficacy of Prophylactic TicagrelOr With Acetylsalicylic Acid Versus CLopidogrel With Acetylsalicylic Acid in the Development of Cerebrovascular EMbolic Events During Transcatheter Aortic Valve Implantation (TAVI) OperationS - the PTOLEMAIOS Study. Unknown status NCT02989558 Phase 3 Ticagrelor plus ASA;Clopidogrel plus ASA
3 Surgical Manipulation of the Ascending Aorta and Cerebral Infarction Following CABG Unknown status NCT00558779 Phase 2
4 Clinical Study to Evaluate the Efficacy of Blood Purification Therapy on Cholesterol Crystal Embolism Recruiting NCT01726868 Phase 2
5 Efficacy of Prednisone in Patients With Severe Systemic Atheroembolism (Cholesterol Cristal Embolism) Terminated NCT01452100 Phase 2 prednisone
6 Randomised Controlled Trial Evaluating Prophylactic Intravenous Hydration for the Prevention of Contrast Induced Nephropathy Completed NCT02106234

Search NIH Clinical Center for Cholesterol Embolism

Cochrane evidence based reviews: embolism, cholesterol

Genetic Tests for Cholesterol Embolism

Anatomical Context for Cholesterol Embolism

MalaCards organs/tissues related to Cholesterol Embolism:

41
Kidney, Skin, Colon, Heart, Bone, Bone Marrow, Small Intestine

Publications for Cholesterol Embolism

Articles related to Cholesterol Embolism:

(show top 50) (show all 239)
# Title Authors PMID Year
1
Carpal arch cholesterol embolism. 38
31387446 2019
2
[Prevention of "contrast-induced" acute kidney injury - practical considerations]. 38
31350739 2019
3
Acute Renal Failure of Nosocomial Origin. 38
30961801 2019
4
Slender transradial iliac artery stenting using a 4.5 French guiding sheath. 38
29305825 2019
5
Midterm Outcomes of Endovascular Aortic Aneurysm Repair with Carbon Dioxide-Guided Angiography. 38
29772311 2018
6
Novel Insights into Crystal-Induced Kidney Injury. 38
29998119 2018
7
Cholesterol embolism: it's always a good idea to look into the eye. 38
28939621 2017
8
The Cholesterol Embolism Syndrome. 38
28446355 2017
9
Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review. 38
27446313 2016
10
Late Onset of Cholesterol Embolism Leading to Graft Failure After Renal Transplantation: Report of Two Cases. 38
26518927 2015
11
Intestinal cholesterol embolism resulting from intra-aortic balloon pumping: a case report. 38
24951057 2014
12
Millipede burn masquerading as trash foot in a paediatric patient. 38
24168263 2014
13
Atherosclerosis associated with vasculopathic lesions in a golden retriever with hypercholesterolemia. 38
24790237 2014
14
Clinical Neuropathology practice guide 3-2014: combined nerve and muscle biopsy in the diagnostic workup of neuropathy - the Bordeaux experience. 38
24618073 2014
15
Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease. 38
24163269 2014
16
Transbrachial carotid artery stenting can prevent renal cholesterol embolism. 38
24785896 2014
17
Initial results of transradial iliac artery stenting. 38
24203346 2014
18
[Foot lesions]. 38
24114468 2013
19
An autopsy case of idiopathic cholesterol embolism. 38
23224026 2013
20
613 cases of splenic rupture without risk factors or previously diagnosed disease: a systematic review. 38
22889306 2012
21
[Atheroembolism renal disease: diagnosis and etiologic factors]. 38
23007816 2012
22
Pitfall in nephrology: contrast nephropathy has to be differentiated from renal damage due to atheroembolic disease. 38
22419233 2012
23
[Cholesterol embolism syndrome: a rare, but severe complication in patients with atherosclerosis]. 38
22588660 2012
24
Multiple renal infarctions due to thromboembolism. Importance of ultrasound in diagnosis. Case report. 38
22396944 2012
25
[Case of purpura nephritis accompanied by idiopathic cholesterol embolism]. 38
22991843 2012
26
Facial livedo racemosa as a warning sign of cholesterol embolism from atherosclerotic plaques of the carotid artery. 38
21571195 2011
27
Marked regression of aortic plaque by intensive cholesterol-lowering therapy. 38
21242651 2011
28
Cholesterol embolism associated with MPO-ANCA. 38
20409998 2010
29
Spontaneous cutaneous cholesterol embolism. 38
19744823 2010
30
Filters placed in the superficial femoral arteries for limb salvage in a high-surgical-risk patient with atheroembolism: results at 2 years. 38
20557183 2010
31
Cutaneous reactive angiomatosis associated with cholesterol embolism. 38
19614996 2010
32
[Atheroembolic renal disease: analysis of clinical and therapeutic factors that influence its progression]. 38
20414329 2010
33
[Penile calciphylaxis: 5-year experience and literature review]. 38
19925764 2009
34
Post-coronary stenting renal cholesterol embolism treated by renal artery stenting. 38
19819797 2009
35
Stent placement in patients with atherosclerotic renal artery stenosis and impaired renal function: a randomized trial. 38
19414832 2009
36
[French 2008 guidelines on peritoneal dialysis: indications and non-indications]. 38
19596349 2009
37
Segmental testicular infarction due to cholesterol embolism: not the first case, but the first report. 38
18844943 2008
38
Aortic thrombus due to essential thrombocytosis: strategies for medical and surgical management. 38
18513483 2008
39
Catastrophic cholesterol crystal embolization after endovascular stent placement for peripheral vascular disease. 38
18480661 2008
40
[Cholesterol embolism causing ischemic colitis]. 38
18662086 2008
41
Cholesterol embolism evaluated by polarized light microscopy after primary renal artery stent placement with filter protection. 38
18341947 2008
42
[Acute renal failure caused by cholesterol embolism of the intrarenal arteries after coronaroangiography: success of glucocorticosteroid treatment]. 38
18807542 2008
43
[Spontaneous cholesterol embolism confused with peripheral arterial disease]. 38
18065361 2007
44
[Blue toe syndrome; a sign of end-arterial occlusion]. 38
17624153 2007
45
Non-neoplastic renal diseases in Kerala, India--analysis of 1592 cases, a two year retrospective study. 38
17883050 2007
46
Steroid-responsive leucoencephalopathy due to cholesterol embolism. 38
17229741 2007
47
Reversible encephalopathy associated with cholesterol embolism syndrome: magnetic resonance imaging and pathological findings. 38
17229746 2007
48
Facial cutaneous cholesterol embolism revealing a tight carotid stenosis: a case report. 38
17067829 2007
49
Cholesterol embolism: still an unrecognized entity with a high mortality rate. 38
17052483 2006
50
Simultaneous surgical treatment of abdominal aortic aneurysm and bilateral aneurysms of the internal iliac artery. 38
17290693 2006

Variations for Cholesterol Embolism

Expression for Cholesterol Embolism

Search GEO for disease gene expression data for Cholesterol Embolism.

Pathways for Cholesterol Embolism

GO Terms for Cholesterol Embolism

Sources for Cholesterol Embolism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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