MCID: CHL045
MIFTS: 33

Choline Deficiency Disease

Categories: Metabolic diseases

Aliases & Classifications for Choline Deficiency Disease

MalaCards integrated aliases for Choline Deficiency Disease:

Name: Choline Deficiency Disease 12 15
Choline Deficiency 12 55 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8456
MeSH 44 D002796
SNOMED-CT 68 238113006
UMLS 73 C0008412

Summaries for Choline Deficiency Disease

MalaCards based summary : Choline Deficiency Disease, also known as choline deficiency, is related to nonalcoholic steatohepatitis and fatty liver disease. An important gene associated with Choline Deficiency Disease is PEMT (Phosphatidylethanolamine N-Methyltransferase), and among its related pathways/superpathways are Metabolism and Glycerophospholipid biosynthesis. The drugs leucovorin and Choline have been mentioned in the context of this disorder. Affiliated tissues include liver, neutrophil and skin.

Wikipedia : 76 Choline /ˈkoʊliːn/ is a water-soluble vitamin-like essential nutrient. It is a constituent of lecithin,... more...

Related Diseases for Choline Deficiency Disease

Diseases related to Choline Deficiency Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 nonalcoholic steatohepatitis 10.2
2 fatty liver disease 10.0
3 hepatitis 9.9
4 liver disease 9.8
5 nonalcoholic fatty liver disease 9.8
6 toxocariasis 9.7 SLC44A1 SLC44A2
7 diabetes mellitus, noninsulin-dependent 9.6
8 fatty liver disease, nonalcoholic 1 9.6
9 infantile liver failure syndrome 1 9.6
10 liver cirrhosis 9.6
11 postural orthostatic tachycardia syndrome 9.6
12 glucose intolerance 9.6
13 selenium poisoning 9.6
14 isolated hyperckemia 9.6

Graphical network of the top 20 diseases related to Choline Deficiency Disease:



Diseases related to Choline Deficiency Disease

Symptoms & Phenotypes for Choline Deficiency Disease

Drugs & Therapeutics for Choline Deficiency Disease

Drugs for Choline Deficiency Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
2
Choline Approved, Nutraceutical Not Applicable 62-49-7 305
3
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
4 Micronutrients Not Applicable
5 Gastrointestinal Agents Not Applicable
6 Hematinics Not Applicable
7 Nootropic Agents Not Applicable
8 Hormone Antagonists Not Applicable
9 Trace Elements Not Applicable
10 Hormones Not Applicable
11 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
12 Vitamin B Complex Not Applicable
13 Hypolipidemic Agents Not Applicable
14 Vitamins Not Applicable
15 Estrogens Not Applicable
16 Lipid Regulating Agents Not Applicable
17 Antimetabolites Not Applicable
18 Liver Extracts
19 Folate Nutraceutical Not Applicable
20 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Choline Nutrition in Children With Cystic Fibrosis (CF) Completed NCT00686361 Not Applicable Choline supplementation
2 Cracking the Egg Potential: Improving Young Child Nutrition in Ecuador Completed NCT02446873 Not Applicable
3 Parental One-carbon Folate and Choline Nutrition Modulates Risk of Off-spring Cancer Development: Human Cohort Study Completed NCT02266641 Not Applicable
4 Human Requirements for the Nutrient Choline Completed NCT00065546 Not Applicable
5 Evaluation of the Involvement of the Intestinal Microbiota and Choline Deficiency in the Severity of Chronic Liver Disease Explored by Analyzing Collection of Biological Samples (MICRONACH) Recruiting NCT02650115

Search NIH Clinical Center for Choline Deficiency Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: choline deficiency

Genetic Tests for Choline Deficiency Disease

Anatomical Context for Choline Deficiency Disease

MalaCards organs/tissues related to Choline Deficiency Disease:

41
Liver, Neutrophil, Skin, Heart

Publications for Choline Deficiency Disease

Articles related to Choline Deficiency Disease:

(show all 45)
# Title Authors Year
1
Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis. ( 29930468 )
2018
2
Growth arrest and DNA damage-inducible 45I+ protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet. ( 28844958 )
2017
3
Imatinib accelerates progenitor cell-mediated liver regeneration in choline-deficient ethionine-supplemented diet-fed mice. ( 27918111 )
2016
4
S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway. ( 27313828 )
2016
5
The Ethanol Extract from Lonicera japonica Thunb. Regresses Nonalcoholic Steatohepatitis in a Methionine- and Choline-Deficient Diet-Fed Animal Model. ( 26506376 )
2015
6
Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism. ( 25649792 )
2015
7
A role of 1,25(OH)2D3 supplementation in rats with nonalcoholic steatohepatitis induced by choline-deficient diet. ( 25843661 )
2015
8
Raloxifene Ameliorates Liver Fibrosis of Nonalcoholic Steatohepatitis Induced by Choline-Deficient High-Fat Diet in Ovariectomized Mice. ( 25868633 )
2015
9
Hepatoprotective and antioxidant activities of extracts from Salvia-Nelumbinis naturalis against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet in mice. ( 25406833 )
2014
10
Deficiency of periostin protects mice against methionine-choline-deficient diet-induced nonalcoholic steatohepatitis. ( 25308174 )
2014
11
Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts. ( 25466896 )
2014
12
Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats. ( 25250392 )
2014
13
Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency. ( 24329600 )
2014
14
Dynamics of oxidative/nitrosative stress in mice with methionine-choline-deficient diet-induced nonalcoholic fatty liver disease. ( 24130212 )
2013
15
Heart dysfunction induced by choline-deficiency in adult rats: the protective role of L-carnitine. ( 23562624 )
2013
16
Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation. ( 23481610 )
2013
17
Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid-defined diet. ( 23682724 )
2013
18
Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice. ( 24294355 )
2013
19
Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet. ( 22556147 )
2012
20
Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyperhomocysteinemia in rats. ( 22790565 )
2012
21
Effect of dietary supplementation with folate on choline deficiency-induced hyperhomocysteinemia in rats. ( 23007063 )
2012
22
Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats. ( 22790564 )
2012
23
Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. ( 21059658 )
2011
24
Methionine and serine synergistically suppress hyperhomocysteinemia induced by choline deficiency, but not by guanidinoacetic acid, in rats fed a low casein diet. ( 22146711 )
2011
25
Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model. ( 18986378 )
2010
26
Variable number tandem repeats in the promoter region of prostacyclin synthase gene in choline deficient rats. ( 20925195 )
2010
27
Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet. ( 20374300 )
2010
28
Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. ( 19552763 )
2009
29
MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. ( 19572984 )
2009
30
Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. ( 18778692 )
2008
31
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. ( 18299981 )
2008
32
Alpha-lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model. ( 17893235 )
2008
33
A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet. ( 16804070 )
2006
34
Effect of hepatocyte growth factor on endogenous hepatocarcinogenesis in rats fed a choline-deficient L-amino acid-defined diet. ( 16786119 )
2006
35
Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient diet. ( 15650132 )
2005
36
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. ( 16236726 )
2005
37
Sex differences in choline-deficient diet-induced steatohepatitis in mice. ( 14734794 )
2004
38
Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts. ( 15213044 )
2004
39
Dimethylethanolamine does not prevent liver failure in phosphatidylethanolamine N-methyltransferase-deficient mice fed a choline-deficient diet. ( 15164765 )
2004
40
Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet. ( 15464239 )
2004
41
Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. ( 15013444 )
2004
42
Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet. ( 12708470 )
2003
43
Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: proof of a human choline requirement: a placebo-controlled trial. ( 11531217 )
2001
44
Induction of foci of altered, gamma-glutamyltranspeptidase-positive hepatocytes in carcinogen-treated rats fed a choline-deficient diet. ( 89859 )
1979
45
Effect of choline deficiency on chronic selenium poisoning of rats. ( 13444599 )
1957

Variations for Choline Deficiency Disease

Expression for Choline Deficiency Disease

Search GEO for disease gene expression data for Choline Deficiency Disease.

Pathways for Choline Deficiency Disease

GO Terms for Choline Deficiency Disease

Cellular components related to Choline Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.96 MGST2 MGST3
2 endoplasmic reticulum membrane GO:0005789 8.92 MGST2 MGST3 PEMT PLP2

Biological processes related to Choline Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 9.46 MGST2 MGST3
2 cellular oxidant detoxification GO:0098869 9.43 MGST2 MGST3
3 response to organonitrogen compound GO:0010243 9.4 MGST2 MGST3
4 glutathione derivative biosynthetic process GO:1901687 9.37 MGST2 MGST3
5 leukotriene biosynthetic process GO:0019370 9.32 MGST2 MGST3
6 choline transport GO:0015871 9.26 SLC44A1 SLC44A2
7 S-adenosylmethionine metabolic process GO:0046500 9.16 BHMT PEMT
8 phosphatidylcholine biosynthetic process GO:0006656 9.13 PEMT SLC44A1 SLC44A2
9 choline catabolic process GO:0042426 8.8 BHMT CHDH SLC44A1

Molecular functions related to Choline Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 9.26 MGST2 MGST3
2 glutathione peroxidase activity GO:0004602 9.16 MGST2 MGST3
3 choline transmembrane transporter activity GO:0015220 8.96 SLC44A1 SLC44A2
4 leukotriene-C4 synthase activity GO:0004464 8.62 MGST2 MGST3

Sources for Choline Deficiency Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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