MCID: CHL045
MIFTS: 37

Choline Deficiency Disease

Categories: Metabolic diseases

Aliases & Classifications for Choline Deficiency Disease

MalaCards integrated aliases for Choline Deficiency Disease:

Name: Choline Deficiency Disease 12 15
Choline Deficiency 12 55 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8456
MeSH 44 D002796
UMLS 73 C0008412

Summaries for Choline Deficiency Disease

MalaCards based summary : Choline Deficiency Disease, also known as choline deficiency, is related to fatty liver disease and nonalcoholic steatohepatitis. An important gene associated with Choline Deficiency Disease is PEMT (Phosphatidylethanolamine N-Methyltransferase), and among its related pathways/superpathways are Metabolism and Glycerophospholipid biosynthesis. Affiliated tissues include liver, brain and kidney.

Wikipedia : 76 Choline /�?ko�?liːn/ is a water-soluble vitamin-like essential nutrient. It is a constituent of... more...

Related Diseases for Choline Deficiency Disease

Diseases related to Choline Deficiency Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 fatty liver disease 10.4
2 nonalcoholic steatohepatitis 10.4
3 liver disease 10.1
4 fatty liver disease, nonalcoholic 1 10.1
5 nonalcoholic fatty liver disease 10.0
6 muscular dystrophy 10.0
7 toxocariasis 9.9 SLC44A1 SLC44A2
8 colitis 9.9
9 hepatocellular carcinoma 9.7
10 fish-eye disease 9.7
11 polykaryocytosis inducer 9.7
12 alzheimer disease 5 9.7
13 infantile liver failure syndrome 1 9.7
14 liver cirrhosis 9.7
15 dengue shock syndrome 9.7
16 thrombosis 9.7
17 postural orthostatic tachycardia syndrome 9.7
18 glucose intolerance 9.7
19 renal hypertension 9.7
20 vascular disease 9.7
21 arteriosclerosis 9.7
22 selenium poisoning 9.7
23 isolated hyperckemia 9.7

Graphical network of the top 20 diseases related to Choline Deficiency Disease:



Diseases related to Choline Deficiency Disease

Symptoms & Phenotypes for Choline Deficiency Disease

Drugs & Therapeutics for Choline Deficiency Disease

Search Clinical Trials , NIH Clinical Center for Choline Deficiency Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: choline deficiency

Genetic Tests for Choline Deficiency Disease

Anatomical Context for Choline Deficiency Disease

MalaCards organs/tissues related to Choline Deficiency Disease:

41
Liver, Brain, Kidney, Lung, Heart, Fetal Brain, Bone

Publications for Choline Deficiency Disease

Articles related to Choline Deficiency Disease:

(show top 50) (show all 268)
# Title Authors Year
1
Effect of Phyllanthus emblica L. fruit on methionine and choline-deficiency diet-induced nonalcoholic steatohepatitis. ( 30249323 )
2018
2
Evaluation of polyherbal formulation and synthetic choline chloride on choline deficiency model in broilers: implications on zootechnical parameters, serum biochemistry and liver histopathology. ( 29642669 )
2018
3
Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency. ( 27981809 )
2017
4
Choline Deficiency Causes Colonic Type II Natural Killer T (NKT) Cell Loss and Alleviates Murine Colitis under Type I NKT Cell Deficiency. ( 28095507 )
2017
5
A Comparative Study on Antioxidant System in Fish Hepatopancreas and Intestine Affected by Choline Deficiency: Different Change Patterns of Varied Antioxidant Enzyme Genes and Nrf2 Signaling Factors. ( 28099509 )
2017
6
Intestinal immune responses of Jian carp against Aeromonas hydrophila depressed by choline deficiency: Varied change patterns of mRNA levels of cytokines, tight junction proteins and related signaling molecules among three intestinal segments. ( 28366783 )
2017
7
Comparative study of fatty liver induced by methionine and choline-deficiency in C57BL/6N mice originating from three different sources. ( 28747982 )
2017
8
Erratum: Comparative study of fatty liver induced by methionine and choline-deficiency in C57BL/6N mice originating from three different sources. ( 29399032 )
2017
9
Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. ( 26046479 )
2016
10
Dietary choline deficiency and excess induced intestinal inflammation and alteration of intestinal tight junction protein transcription potentially by modulating NF-κB, STAT and p38 MAPK signaling molecules in juvenile Jian carp. ( 27693201 )
2016
11
Perinatal Dietary Choline Deficiency in Sows Influences Concentrations of Choline Metabolites, Fatty Acids, and Amino Acids in Milk throughout Lactation. ( 27733523 )
2016
12
Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency. ( 25193852 )
2015
13
Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency. ( 25536170 )
2015
14
Choline deficiency impairs intestinal lipid metabolism in the lactating rat. ( 26092371 )
2015
15
Moderate Perinatal Choline Deficiency Elicits Altered Physiology and Metabolomic Profiles in the Piglet. ( 26196148 )
2015
16
Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts. ( 25466896 )
2014
17
Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats. ( 25250392 )
2014
18
Heart dysfunction induced by choline-deficiency in adult rats: the protective role of L-carnitine. ( 23562624 )
2013
19
The protective effect of menhaden oil in the oxidative damage and renal necrosis due to dietary choline deficiency. ( 23235886 )
2013
20
Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet. ( 24009777 )
2013
21
Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyperhomocysteinemia in rats. ( 22790565 )
2012
22
Effect of dietary supplementation with folate on choline deficiency-induced hyperhomocysteinemia in rats. ( 23007063 )
2012
23
Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats. ( 22790564 )
2012
24
Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice. ( 22778916 )
2012
25
Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones. ( 22041500 )
2012
26
Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. ( 21059658 )
2011
27
Methionine and serine synergistically suppress hyperhomocysteinemia induced by choline deficiency, but not by guanidinoacetic acid, in rats fed a low casein diet. ( 22146711 )
2011
28
Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease. ( 22083307 )
2011
29
Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis. ( 21119028 )
2011
30
Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. ( 21129376 )
2011
31
Effect of vitamin K2 on cortical and cancellous bone mass and hepatic lipids in rats with combined methionine-choline deficiency. ( 21352961 )
2011
32
Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. ( 21840511 )
2011
33
Interaction between total body gamma-irradiation and choline deficiency triggers immediate modulation of choline and choline-containing moieties. ( 21923302 )
2011
34
Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene. ( 19752176 )
2010
35
Oxidative damage: the biochemical mechanism of cellular injury and necrosis in choline deficiency. ( 19913531 )
2010
36
Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. ( 20624989 )
2010
37
Increased susceptibility to experimental steatohepatitis induced by methionine-choline deficiency in HBs-Tg mice. ( 20943461 )
2010
38
Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. ( 18778692 )
2008
39
Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. ( 17399691 )
2007
40
Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. ( 17724018 )
2007
41
A developmental cycle masks output from the circadian oscillator under conditions of choline deficiency in Neurospora. ( 18056807 )
2007
42
Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. ( 16394266 )
2006
43
Diethanolamine and phenobarbital produce an altered pattern of methylation in GC-rich regions of DNA in B6C3F1 mouse hepatocytes similar to that resulting from choline deficiency. ( 16396840 )
2006
44
Distinct effects of folate and choline deficiency on plasma kinetics of methionine and homocysteine in rats. ( 16784961 )
2006
45
Choline deficiency is associated with increased risk for venous catheter thrombosis. ( 16804129 )
2006
46
Choline deficiency increases lymphocyte apoptosis and DNA damage in humans. ( 16825685 )
2006
47
LINE-1 hypomethylation in a choline-deficiency-induced liver cancer in rats: dependence on feeding period. ( 16877811 )
2006
48
Ocular lesions and experimental choline deficiency. ( 17137170 )
2006
49
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. ( 16236726 )
2005
50
Regulation of choline deficiency apoptosis by epidermal growth factor in CWSV-1 rat hepatocytes. ( 15665516 )
2005

Variations for Choline Deficiency Disease

Expression for Choline Deficiency Disease

Search GEO for disease gene expression data for Choline Deficiency Disease.

Pathways for Choline Deficiency Disease

GO Terms for Choline Deficiency Disease

Cellular components related to Choline Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.56 CHDH MGST2 MGST3 MTHFD1L PEMT PLP2
2 organelle membrane GO:0031090 9.16 MGST2 MGST3
3 endoplasmic reticulum membrane GO:0005789 8.92 MGST2 MGST3 PEMT PLP2

Biological processes related to Choline Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.65 MGST2 MGST3 PEMT
2 xenobiotic metabolic process GO:0006805 9.46 MGST2 MGST3
3 cellular oxidant detoxification GO:0098869 9.43 MGST2 MGST3
4 response to organonitrogen compound GO:0010243 9.4 MGST2 MGST3
5 glutathione derivative biosynthetic process GO:1901687 9.37 MGST2 MGST3
6 leukotriene biosynthetic process GO:0019370 9.32 MGST2 MGST3
7 choline transport GO:0015871 9.26 SLC44A1 SLC44A2
8 S-adenosylmethionine metabolic process GO:0046500 9.16 BHMT PEMT
9 phosphatidylcholine biosynthetic process GO:0006656 9.13 PEMT SLC44A1 SLC44A2
10 choline catabolic process GO:0042426 8.8 BHMT CHDH SLC44A1

Molecular functions related to Choline Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 9.26 MGST2 MGST3
2 glutathione peroxidase activity GO:0004602 9.16 MGST2 MGST3
3 choline transmembrane transporter activity GO:0015220 8.96 SLC44A1 SLC44A2
4 leukotriene-C4 synthase activity GO:0004464 8.62 MGST2 MGST3

Sources for Choline Deficiency Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....