MCID: CHL035
MIFTS: 28

Cholinergic Urticaria

Categories: Skin diseases

Aliases & Classifications for Cholinergic Urticaria

MalaCards integrated aliases for Cholinergic Urticaria:

Name: Cholinergic Urticaria 12 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14443
ICD9CM 36 708.5
SNOMED-CT 69 73098005
ICD10 34 L50.5
UMLS 74 C0152230

Summaries for Cholinergic Urticaria

Disease Ontology : 12 An urticaria induced by sweating.

MalaCards based summary : Cholinergic Urticaria is related to urticaria and anhidrosis. An important gene associated with Cholinergic Urticaria is CHRM3 (Cholinergic Receptor Muscarinic 3). The drugs Omalizumab and Anti-Asthmatic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung.

Wikipedia : 77 Cholinergic urticaria (CU) is a type of physical urticaria (or hives) that appears when a person is... more...

Related Diseases for Cholinergic Urticaria

Diseases related to Cholinergic Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 urticaria 10.9
2 anhidrosis 10.5
3 cold urticaria 10.2
4 exercise-induced anaphylaxis 10.2
5 dermatitis 10.1
6 dermatitis, atopic 10.0
7 allergic hypersensitivity disease 10.0
8 angioedema 10.0
9 pfeiffer syndrome 9.9
10 asthma 9.9
11 miliaria rubra 9.9
12 miliaria 9.9
13 wernicke-korsakoff syndrome 9.8 ACHE SERPINA3
14 vascular dementia 9.7 ACHE SERPINA3
15 pulmonary disease, chronic obstructive 9.7 CHRM3 SERPINA3

Graphical network of the top 20 diseases related to Cholinergic Urticaria:



Diseases related to Cholinergic Urticaria

Symptoms & Phenotypes for Cholinergic Urticaria

Drugs & Therapeutics for Cholinergic Urticaria

Drugs for Cholinergic Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2 242138-07-4
2 Anti-Asthmatic Agents Phase 2
3 Anti-Allergic Agents Phase 2
4 Immunologic Factors Phase 2
5 Vaccines Phase 2
6 Neurotransmitter Agents Phase 2
7 Respiratory System Agents Phase 2
8 Cholinergic Agents Phase 2
9 Histamine H1 Antagonists Phase 2
10 Antibodies, Monoclonal Phase 2
11 Histamine Antagonists Phase 2
12 Immunoglobulins Phase 2
13 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Study of Omalizumab in Cholinergic Urticaria Completed NCT02012387 Phase 2
2 Cholinergic Urticaria - Efficacy of Dupilumab Recruiting NCT03749148 Phase 2 Dupilumab;Placebo
3 Pathogenesis of Physical Induced Urticarial Syndromes Recruiting NCT00887939

Search NIH Clinical Center for Cholinergic Urticaria

Genetic Tests for Cholinergic Urticaria

Anatomical Context for Cholinergic Urticaria

MalaCards organs/tissues related to Cholinergic Urticaria:

42
Skin, Testes, Lung, Neutrophil

Publications for Cholinergic Urticaria

Articles related to Cholinergic Urticaria:

(show top 50) (show all 117)
# Title Authors Year
1
Angioedema frequently occurs in cholinergic urticaria. ( 30368007 )
2019
2
Real-life treatment of cholinergic urticaria with omalizumab. ( 30312709 )
2019
3
Efficacy and safety of omalizumab (Xolair®) for cholinergic urticaria in patients unresponsive to a double dose of antihistamines: a randomized mixed double-blind and open-label placebo-controlled clinical trial. ( 30654196 )
2019
4
Exercise-induce anaphylaxis, food-dependent exercise-induce anaphylaxis, cholinergic urticaria and Kounis syndrome. ( 30774109 )
2019
5
Cholinergic urticaria: epidemiology, physiopathology, new categorization, and management. ( 28382552 )
2018
6
Successful treatment of refractory cholinergic urticaria with omalizumab. ( 29057464 )
2018
7
Development and validation of the Cholinergic Urticaria Quality-of-Life Questionnaire (CholU-QoL). ( 29369455 )
2018
8
Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases. ( 27876252 )
2017
9
Cholinergic urticaria: More than a simple inducible urticaria. ( 27173142 )
2017
10
Elevation of serum carcinoembryonic antigen in a case of cholinergic urticaria with failed detection of hypohidrosis by the conventional starch-iodine test. ( 27864842 )
2017
11
A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration. ( 28108244 )
2017
12
Case of cholinergic urticaria accompanied by anaphylaxis. ( 28665007 )
2017
13
Cholinergic urticaria: Clinicoepidemiological paradigms from a tertiary care center in North India. ( 28731013 )
2017
14
Cholinergic urticaria patients of different age groups have distinct features. ( 28873238 )
2017
15
Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity. ( 26619922 )
2016
16
Unique case of postural cholinergic urticaria induced by a standing position. ( 26801200 )
2016
17
Addition of lafutidine can improve disease activity and lead to better quality of life in refractory cholinergic urticaria unresponsive to histamine H1 antagonists. ( 26896422 )
2016
18
Exercise-induced urticaria, cholinergic urticaria, and Kounis syndrome. ( 27127399 )
2016
19
Atopic predisposition in cholinergic urticaria patients and its implications. ( 27324252 )
2016
20
Antihistamine updosing reduces disease activity in patients with difficult-to-treat cholinergic urticaria. ( 27496595 )
2016
21
New Etiology of Cholinergic Urticaria. ( 27584968 )
2016
22
Pure Cold-Induced Cholinergic Urticaria in a Pediatric Patient. ( 28025628 )
2016
23
Combined cholinergic urticaria and cold-induced cholinergic urticaria with acquired idiopathic generalized anhidrosis. ( 25838106 )
2015
24
The significance of hypersensitivity to autologous sweat and serum in cholinergic urticaria: cholinergic urticaria may have different subtypes. ( 25069826 )
2015
25
Successful treatment of cholinergic urticaria with methantheliniumbromide. ( 25571938 )
2015
26
Cholinergic urticaria and exercise-induced anaphylaxis. ( 25574887 )
2015
27
Cholinergic urticaria with anaphylaxis: hazardous duty of a deployed US marine. ( 25942027 )
2015
28
Healing effects of omalizumab in a patient with cholinergic urticaria associated severe dyspeptic complaints. ( 26021519 )
2015
29
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. ( 23748235 )
2014
30
Physical urticarias and cholinergic urticaria. ( 24262690 )
2014
31
Elevated serum IgE against MGL_1304 in patients with atopic dermatitis and cholinergic urticaria. ( 24457815 )
2014
32
Development of a standardized pulse-controlled ergometry test for diagnosing and investigating cholinergic urticaria. ( 24837213 )
2014
33
Clinical characteristics of cholinergic urticaria in Korea. ( 24882973 )
2014
34
Idiopathic pure sudomotor failure and cholinergic urticaria in a patient after acute infectious mononucleosis infection. ( 22924754 )
2013
35
Cholinergic urticaria responding to botulinum toxin injection for axillary hyperhidrosis. ( 23301956 )
2013
36
Prevalence of cholinergic urticaria in Indian adults. ( 23437429 )
2013
37
Anaphylaxislike cholinergic urticaria. ( 23851539 )
2013
38
Cholinergic urticaria: pathogenesis-based categorization and its treatment options. ( 21371134 )
2012
39
Is cholinergic urticaria a seasonal disorder in some patients? ( 22421654 )
2012
40
Histamine release-neutralization assay for sera of patients with atopic dermatitis and/or cholinergic urticaria is useful to screen type I hypersensitivity against sweat antigens. ( 22526323 )
2012
41
Efficacy of stellate ganglion block in cholinergic urticaria with acquired generalized hypohidrosis. ( 23091692 )
2012
42
Pathogenesis of cholinergic urticaria in relation to sweating. ( 23093795 )
2012
43
Evaluation of different combined regimens in the treatment of cholinergic urticaria. ( 23283179 )
2012
44
Epileptic seizures and cholinergic urticaria with generalized hypohidrosis or anhidrosis. ( 21233059 )
2011
45
Cholinergic urticaria associated with acquired hypohidrosis: an ultrastructural study. ( 21103837 )
2011
46
Rapid desensitization with autologous sweat in cholinergic urticaria. ( 21364312 )
2011
47
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and reduced acetylcholine receptors: cause and effect? ( 21392081 )
2011
48
Failure of omalizumab in cholinergic urticaria. ( 19925484 )
2010
49
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and abnormal neurological findings: association with incomplete Ross syndrome? ( 20199537 )
2010
50
Cholinergic urticaria: studies on the muscarinic cholinergic receptor M3 in anhidrotic and hypohidrotic skin. ( 20613776 )
2010

Variations for Cholinergic Urticaria

Expression for Cholinergic Urticaria

Search GEO for disease gene expression data for Cholinergic Urticaria.

Pathways for Cholinergic Urticaria

GO Terms for Cholinergic Urticaria

Biological processes related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA replication GO:0006260 8.62 ACHE POLK

Molecular functions related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acetylcholine binding GO:0042166 8.62 ACHE CHRM3

Sources for Cholinergic Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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