MCID: CHL035
MIFTS: 30

Cholinergic Urticaria

Categories: Skin diseases

Aliases & Classifications for Cholinergic Urticaria

MalaCards integrated aliases for Cholinergic Urticaria:

Name: Cholinergic Urticaria 12 15 17 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:14443
ICD9CM 34 708.5
SNOMED-CT 67 73098005
ICD10 32 L50.5
UMLS 71 C0152230

Summaries for Cholinergic Urticaria

Disease Ontology : 12 An urticaria induced by sweating.

MalaCards based summary : Cholinergic Urticaria is related to urticaria and anhidrosis. An important gene associated with Cholinergic Urticaria is CHRM3 (Cholinergic Receptor Muscarinic 3). The drugs Omalizumab and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung.

Wikipedia : 74 Cholinergic urticaria (CU) is a type of physical urticaria (or hives) that appears when a person is... more...

Related Diseases for Cholinergic Urticaria

Diseases related to Cholinergic Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 urticaria 31.2 SERPING1 HRH1 FCER1A
2 anhidrosis 31.1 CHRM3 ACHE
3 dermatitis, atopic 30.0 SERPINA3 HRH1 FCER1A
4 angioedema 29.9 SERPING1 KNG1 HRH1
5 allergic rhinitis 29.1 KNG1 HRH1 FCER1A
6 asthma 28.3 SERPINA3 KNG1 HRH1 FCER1A CHRM3
7 physical urticaria 27.7 SERPING1 SERPINA3 RAX2 KNG1 HRH1 FCER1A
8 allergic hypersensitivity disease 10.4
9 cold urticaria 10.4
10 exercise-induced anaphylaxis 10.4
11 ige responsiveness, atopic 10.3
12 exanthem 10.3
13 aplasia of lacrimal and salivary glands 10.2 HRH1 CHRM3
14 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
15 dermatitis 10.2
16 thiamine deficiency disease 10.1 SERPINA3 ACHE
17 wernicke-korsakoff syndrome 10.1 SERPINA3 ACHE
18 neuromuscular junction disease 10.1 SERPINA3 ACHE
19 myasthenic syndrome, congenital, 5 10.1 SERPINA3 ACHE
20 nose disease 10.0 SERPINA3 HRH1
21 intestinal obstruction 10.0 SERPINA3 ACHE
22 pfeiffer syndrome 9.9
23 vibratory urticaria 9.9
24 yemenite deaf-blind hypopigmentation syndrome 9.9
25 common cold 9.9
26 miliaria rubra 9.9
27 visual epilepsy 9.9
28 miliaria 9.9
29 contact dermatitis 9.9
30 allergic contact dermatitis 9.9
31 skin disease 9.9
32 rhinitis 9.9
33 ulcerative colitis 9.9
34 autonomic dysfunction 9.9
35 fainting 9.9
36 seizure disorder 9.9
37 syncope 9.9
38 solar urticaria 9.9
39 sphingolipidosis 9.8 SERPINA3 ETFA
40 hydrops, lactic acidosis, and sideroblastic anemia 9.8 SERPING1 KNG1
41 scrapie 9.7 SERPINA3 ACHE
42 dermatographia 9.6 SERPING1 FCER1A ETFA
43 c1 inhibitor deficiency 9.5 SERPING1 SERPINA3 KNG1
44 integumentary system disease 9.5 SERPING1 SERPINA3 KNG1
45 peripheral nervous system disease 9.5 SERPINA3 KNG1 ACHE
46 hereditary angioedema 9.5 SERPING1 KNG1
47 allergic urticaria 9.4 SERPING1 KNG1 FCER1A

Graphical network of the top 20 diseases related to Cholinergic Urticaria:



Diseases related to Cholinergic Urticaria

Symptoms & Phenotypes for Cholinergic Urticaria

Drugs & Therapeutics for Cholinergic Urticaria

Drugs for Cholinergic Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2 242138-07-4
2 Respiratory System Agents Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2
5 Vaccines Phase 2
6 Anti-Allergic Agents Phase 2
7 Antibodies, Monoclonal Phase 2
8 Immunologic Factors Phase 2
9 Anti-Asthmatic Agents Phase 2
10 Cholinergic Agents Phase 2
11 Histamine H1 Antagonists Phase 2
12 Histamine Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Randomized, Double-blind, Placebo-controlled Parallel Clinical Trial to Assess Efficacy and Safety of Omalizumab (Xolair®) in a New Indication: Cholinergic Urticarial Completed NCT02012387 Phase 2
2 A Randomized, Double-blind, Placebo-controlled, Multicenter, 16-week Treatment Study With a 16 Week Follow-up Period to Assess the Efficacy and Safety of Dupilumab (Anti-IL4Ra) in Adult Patients With Cholinergic Urticaria Despite H1-antihistamine Treatment Recruiting NCT03749148 Phase 2 Dupilumab;Placebo
3 Pathogenesis and Genetic Basis of Physical Induced Urticarial Syndromes Recruiting NCT00887939

Search NIH Clinical Center for Cholinergic Urticaria

Genetic Tests for Cholinergic Urticaria

Anatomical Context for Cholinergic Urticaria

MalaCards organs/tissues related to Cholinergic Urticaria:

40
Skin, Testes, Lung, Neutrophil

Publications for Cholinergic Urticaria

Articles related to Cholinergic Urticaria:

(show top 50) (show all 243)
# Title Authors PMID Year
1
Direct and indirect action modes of acetylcholine in cholinergic urticaria. 61
32565175 2020
2
Regular sweating activities for the treatment of cholinergic urticaria with or without acquired idiopathic generalized anhidrosis. 61
32445244 2020
3
Clinical utility of the basophil activation test in the diagnosis of sweat allergy. 61
31615718 2020
4
A visual analogue scale for itch and pain in 23 cases of cholinergic urticaria. 61
32242985 2020
5
Cholinergic urticaria with hypohidrosis successfully treated with omalizumab. 61
31663149 2020
6
Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients. 61
32514333 2020
7
Clinico-epidemiological features of chronic urticaria in children: A retrospective analysis of 296 children from a tertiary care institute in Northern India. 61
30264742 2020
8
A case of cold-induced cholinergic urticaria accompanied by cholinergic urticaria showing a positive ice cube test. 61
31451337 2020
9
Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020. 61
32224621 2020
10
Real-life treatment of patients with cholinergic urticaria in German-speaking countries. 61
31765087 2019
11
Dupilumab use in dermatologic conditions beyond atopic dermatitis - a systematic review. 61
31693426 2019
12
Cholinergic synovitis: Description of four cases. 61
31708451 2019
13
Efficacy and Safety of Omalizumab (Xolair) for Cholinergic Urticaria in Patients Unresponsive to a Double Dose of Antihistamines: A Randomized Mixed Double-Blind and Open-Label Placebo-Controlled Clinical Trial. 61
30654196 2019
14
Angioedema frequently occurs in cholinergic urticaria. 61
30368007 2019
15
Epidemiology of urticaria including physical urticaria and angioedema in Korea. 61
29742892 2019
16
Real-life treatment of cholinergic urticaria with omalizumab. 61
30312709 2019
17
Exercise-induce anaphylaxis, food-dependent exercise-induce anaphylaxis, cholinergic urticaria and Kounis syndrome. 61
30774109 2019
18
Sweat allergy. 61
30075993 2018
19
How to Approach Chronic Inducible Urticaria. 61
30033913 2018
20
Chronic inducible urticaria: A systematic review of treatment options. 61
29438771 2018
21
Development and validation of the Cholinergic Urticaria Quality-of-Life Questionnaire (CholU-QoL). 61
29369455 2018
22
Cholinergic urticaria: epidemiology, physiopathology, new categorization, and management. 61
28382552 2018
23
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence. 61
28751232 2018
24
Successful treatment of refractory cholinergic urticaria with omalizumab. 61
29057464 2018
25
Cholinergic urticaria patients of different age groups have distinct features. 61
28873238 2017
26
Case of cholinergic urticaria accompanied by anaphylaxis. 61
28665007 2017
27
Cholinergic urticaria: More than a simple inducible urticaria. 61
27173142 2017
28
Aquagenic Urticaria: A Perplexing Physical Phenomenon. 61
29252177 2017
29
Cholinergic urticaria: Clinicoepidemiological paradigms from a tertiary care center in North India. 61
28731013 2017
30
Serum carcinoembryonic antigen specifically increases among various serum markers of adenocarcinoma in hypohidrosis or conditions related to hypohidrosis. 61
28295553 2017
31
A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration. 61
28108244 2017
32
Sweat allergy: Extrinsic or intrinsic? 61
28416076 2017
33
Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores. 61
28328088 2017
34
Elevation of serum carcinoembryonic antigen in a case of cholinergic urticaria with failed detection of hypohidrosis by the conventional starch-iodine test. 61
27864842 2017
35
Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases. 61
27876252 2017
36
Atopic predisposition in cholinergic urticaria patients and its implications. 61
27324252 2016
37
Clinical and etiologic evaluation of the children with chronic urticaria. 61
27931300 2016
38
Antihistamine updosing reduces disease activity in patients with difficult-to-treat cholinergic urticaria. 61
27496595 2016
39
Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review. 61
27585061 2016
40
Heat urticaria: a revision of published cases with an update on classification and management. 61
26973062 2016
41
Serum carcinoembryonic antigen (CEA) as a clinical marker in acquired idiopathic generalized anhidrosis: a close correlation between serum CEA level and disease activity. 61
26446433 2016
42
Unique case of postural cholinergic urticaria induced by a standing position. 61
26801200 2016
43
The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision. 61
26991006 2016
44
Addition of lafutidine can improve disease activity and lead to better quality of life in refractory cholinergic urticaria unresponsive to histamine H1 antagonists. 61
26896422 2016
45
Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity. 61
26619922 2016
46
Clinical Analysis and Management of Acquired Idiopathic Generalized Anhidrosis. 61
27584965 2016
47
New Etiology of Cholinergic Urticaria. 61
27584968 2016
48
Sweat Allergy. 61
27584969 2016
49
Cross-reactive LTP sensitization in food-dependent exercise-induced urticaria/anaphylaxis: a pilot study of a component-resolved and in vitro depletion approach. 61
28031785 2016
50
Exercise-induced urticaria, cholinergic urticaria, and Kounis syndrome. 61
27127399 2016

Variations for Cholinergic Urticaria

Expression for Cholinergic Urticaria

Search GEO for disease gene expression data for Cholinergic Urticaria.

Pathways for Cholinergic Urticaria

GO Terms for Cholinergic Urticaria

Cellular components related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.33 SERPING1 SERPINA3 KNG1
2 blood microparticle GO:0072562 9.13 SERPING1 SERPINA3 KNG1
3 platelet alpha granule lumen GO:0031093 8.8 SERPING1 SERPINA3 KNG1

Biological processes related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endopeptidase activity GO:0010951 9.43 SERPING1 SERPINA3 KNG1
2 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.4 HRH1 CHRM3
3 hemostasis GO:0007599 9.37 SERPING1 KNG1
4 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.32 HRH1 CHRM3
5 blood coagulation, intrinsic pathway GO:0007597 9.16 SERPING1 KNG1
6 platelet degranulation GO:0002576 9.13 SERPING1 SERPINA3 KNG1
7 negative regulation of peptidase activity GO:0010466 8.8 SERPING1 SERPINA3 KNG1

Molecular functions related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled serotonin receptor activity GO:0004993 9.16 HRH1 CHRM3
2 acetylcholine binding GO:0042166 8.96 CHRM3 ACHE
3 peptidase inhibitor activity GO:0030414 8.8 SERPING1 SERPINA3 KNG1

Sources for Cholinergic Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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