MCID: CHL035
MIFTS: 28

Cholinergic Urticaria

Categories: Skin diseases

Aliases & Classifications for Cholinergic Urticaria

MalaCards integrated aliases for Cholinergic Urticaria:

Name: Cholinergic Urticaria 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14443
ICD10 33 L50.5
ICD9CM 35 708.5
SNOMED-CT 68 73098005
UMLS 73 C0152230

Summaries for Cholinergic Urticaria

Disease Ontology : 12 An urticaria induced by sweating.

MalaCards based summary : Cholinergic Urticaria is related to urticaria and hypohidrosis. An important gene associated with Cholinergic Urticaria is CHRM3 (Cholinergic Receptor Muscarinic 3). The drugs Omalizumab and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Cholinergic urticaria (CU) is a type of physical urticaria (or hives) that appears when a person is... more...

Related Diseases for Cholinergic Urticaria

Diseases related to Cholinergic Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 urticaria 10.9
2 hypohidrosis 10.4
3 anhidrosis 10.2
4 cold urticaria 10.2
5 exercise-induced anaphylaxis 10.2
6 dermatitis 10.1
7 dermatitis, atopic 10.0
8 angioedema 10.0
9 asthma 9.9
10 miliaria 9.9
11 physical urticaria 9.8 MS4A2 RAX2

Graphical network of the top 20 diseases related to Cholinergic Urticaria:



Diseases related to Cholinergic Urticaria

Symptoms & Phenotypes for Cholinergic Urticaria

GenomeRNAi Phenotypes related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 CHRM3 MS4A2
2 Decreased viability GR00381-A-3 9.1 CHRM3 MS4A2
3 Decreased viability GR00402-S-2 9.1 CHRM3 MS4A2

Drugs & Therapeutics for Cholinergic Urticaria

Drugs for Cholinergic Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2 242138-07-4
2 Vaccines Phase 2
3 Anti-Asthmatic Agents Phase 2
4 Anti-Allergic Agents Phase 2
5 Neurotransmitter Agents Phase 2
6 Respiratory System Agents Phase 2
7 Cholinergic Agents Phase 2
8 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Study of Omalizumab in Cholinergic Urticaria Completed NCT02012387 Phase 2
2 Cholinergic Urticaria - Efficacy of Dupilumab Not yet recruiting NCT03749148 Phase 2 Dupilumab;Placebo
3 Pathogenesis of Physical Induced Urticarial Syndromes Recruiting NCT00887939

Search NIH Clinical Center for Cholinergic Urticaria

Genetic Tests for Cholinergic Urticaria

Anatomical Context for Cholinergic Urticaria

MalaCards organs/tissues related to Cholinergic Urticaria:

41
Skin, Testes, Lung, Neutrophil

Publications for Cholinergic Urticaria

Articles related to Cholinergic Urticaria:

(show top 50) (show all 115)
# Title Authors Year
1
Successful treatment of refractory cholinergic urticaria with omalizumab. ( 29057464 )
2018
2
Development and Validation of the Cholinergic Urticaria Quality of Life Questionnaire: CholU-QoL. ( 29369455 )
2018
3
Angioedema frequently occurs in cholinergic urticaria. ( 30368007 )
2018
4
Real-life treatment of cholinergic urticaria with omalizumab. ( 30312709 )
2018
5
Cholinergic urticaria patients of different age groups have distinct features. ( 28873238 )
2017
6
A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration. ( 28108244 )
2017
7
Cholinergic urticaria: Clinicoepidemiological paradigms from a tertiary care center in North India. ( 28731013 )
2017
8
Case of cholinergic urticaria accompanied by anaphylaxis. ( 28665007 )
2017
9
Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases. ( 27876252 )
2017
10
Cholinergic urticaria: epidemiology, physiopathology, new categorization, and management. ( 28382552 )
2017
11
Addition of lafutidine can improve disease activity and lead to better quality of life in refractory cholinergic urticaria unresponsive to histamine H1 antagonists. ( 26896422 )
2016
12
Cholinergic urticaria: More than a simple inducible urticaria. ( 27173142 )
2016
13
New Etiology of Cholinergic Urticaria. ( 27584968 )
2016
14
Unique case of postural cholinergic urticaria induced by a standing position. ( 26801200 )
2016
15
Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity. ( 26619922 )
2016
16
Exercise-induced urticaria, cholinergic urticaria, and Kounis syndrome. ( 27127399 )
2016
17
Atopic predisposition in cholinergic urticaria patients and its implications. ( 27324252 )
2016
18
Elevation of serum carcinoembryonic antigen in a case of cholinergic urticaria with failed detection of hypohidrosis by the conventional starch-iodine test. ( 27864842 )
2016
19
Pure Cold-Induced Cholinergic Urticaria in a Pediatric Patient. ( 28025628 )
2016
20
Antihistamine updosing reduces disease activity in patients with difficult-to-treat cholinergic urticaria. ( 27496595 )
2016
21
Cholinergic urticaria and exercise-induced anaphylaxis. ( 25574887 )
2015
22
Combined cholinergic urticaria and cold-induced cholinergic urticaria with acquired idiopathic generalized anhidrosis. ( 25838106 )
2015
23
Successful treatment of cholinergic urticaria with methantheliniumbromide. ( 25571938 )
2015
24
Healing effects of omalizumab in a patient with cholinergic urticaria associated severe dyspeptic complaints. ( 26021519 )
2015
25
Cholinergic urticaria with anaphylaxis: hazardous duty of a deployed US marine. ( 25942027 )
2015
26
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. ( 23748235 )
2014
27
The significance of hypersensitivity to autologous sweat and serum in cholinergic urticaria: cholinergic urticaria may have different subtypes. ( 25069826 )
2014
28
Physical urticarias and cholinergic urticaria. ( 24262690 )
2014
29
Development of a standardized pulse-controlled ergometry test for diagnosing and investigating cholinergic urticaria. ( 24837213 )
2014
30
Clinical characteristics of cholinergic urticaria in Korea. ( 24882973 )
2014
31
Elevated serum IgE against MGL_1304 in patients with atopic dermatitis and cholinergic urticaria. ( 24457815 )
2014
32
Anaphylaxislike cholinergic urticaria. ( 23851539 )
2013
33
Idiopathic pure sudomotor failure and cholinergic urticaria in a patient after acute infectious mononucleosis infection. ( 22924754 )
2013
34
Cholinergic urticaria responding to botulinum toxin injection for axillary hyperhidrosis. ( 23301956 )
2013
35
Prevalence of cholinergic urticaria in Indian adults. ( 23437429 )
2013
36
Pathogenesis of cholinergic urticaria in relation to sweating. ( 23093795 )
2012
37
Evaluation of different combined regimens in the treatment of cholinergic urticaria. ( 23283179 )
2012
38
Cholinergic urticaria: pathogenesis-based categorization and its treatment options. ( 21371134 )
2012
39
Is cholinergic urticaria a seasonal disorder in some patients? ( 22421654 )
2012
40
Efficacy of stellate ganglion block in cholinergic urticaria with acquired generalized hypohidrosis. ( 23091692 )
2012
41
Histamine release-neutralization assay for sera of patients with atopic dermatitis and/or cholinergic urticaria is useful to screen type I hypersensitivity against sweat antigens. ( 22526323 )
2012
42
Rapid desensitization with autologous sweat in cholinergic urticaria. ( 21364312 )
2011
43
Cholinergic urticaria associated with acquired hypohidrosis: an ultrastructural study. ( 21103837 )
2011
44
Epileptic seizures and cholinergic urticaria with generalized hypohidrosis or anhidrosis. ( 21233059 )
2011
45
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and reduced acetylcholine receptors: cause and effect? ( 21392081 )
2011
46
Cholinergic urticaria: studies on the muscarinic cholinergic receptor M3 in anhidrotic and hypohidrotic skin. ( 20613776 )
2010
47
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and abnormal neurological findings: association with incomplete Ross syndrome? ( 20199537 )
2010
48
Failure of omalizumab in cholinergic urticaria. ( 19925484 )
2010
49
Bronchial hyperresponsiveness in patients with cholinergic urticaria. ( 19492664 )
2009
50
New concepts of hive formation in cholinergic urticaria. ( 19656473 )
2009

Variations for Cholinergic Urticaria

Expression for Cholinergic Urticaria

Search GEO for disease gene expression data for Cholinergic Urticaria.

Pathways for Cholinergic Urticaria

GO Terms for Cholinergic Urticaria

Biological processes related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA replication GO:0006260 8.62 ACHE POLK

Molecular functions related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acetylcholine binding GO:0042166 8.62 ACHE CHRM3

Sources for Cholinergic Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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