MCID: CHL035
MIFTS: 29

Cholinergic Urticaria

Categories: Skin diseases

Aliases & Classifications for Cholinergic Urticaria

MalaCards integrated aliases for Cholinergic Urticaria:

Name: Cholinergic Urticaria 12 15 17 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:14443
ICD9CM 34 708.5
SNOMED-CT 67 73098005
ICD10 32 L50.5
UMLS 71 C0152230

Summaries for Cholinergic Urticaria

Disease Ontology : 12 A physical urticaria induced by sweating.

MalaCards based summary : Cholinergic Urticaria is related to anhidrosis and urticaria. An important gene associated with Cholinergic Urticaria is CHRM3 (Cholinergic Receptor Muscarinic 3). The drugs Omalizumab and Anti-Asthmatic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia : 74 Cholinergic urticaria (CU) is a type of physical urticaria (or hives) that appears when a person is... more...

Related Diseases for Cholinergic Urticaria

Diseases related to Cholinergic Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 anhidrosis 31.0 CHRM3 ACHE
2 urticaria 30.8 SERPING1 HRH1 FCER1A ENPP3
3 angioedema 30.3 SERPING1 HRH1
4 chronic urticaria 30.2 HRH1 FCER1A ENPP3
5 chronic inducible urticaria 29.9 SERPINA3 FCER1A ENPP3
6 skin disease 29.2 SERPING1 SERPINA3 HRH1
7 physical urticaria 28.9 SERPING1 SERPINA3 HRH1 FCER1A ETFA ENPP3
8 exercise-induced anaphylaxis 10.4
9 cold urticaria 10.3
10 allergic disease 10.3
11 ige responsiveness, atopic 10.3
12 dermatitis, atopic 10.3
13 exanthem 10.2
14 dermatitis 10.2
15 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
16 thiamine deficiency disease 10.1 SERPINA3 ACHE
17 wernicke-korsakoff syndrome 10.1 SERPINA3 ACHE
18 neuromuscular junction disease 10.1 SERPINA3 ACHE
19 nose disease 10.1 SERPINA3 HRH1
20 myasthenic syndrome, congenital, 5 10.1 SERPINA3 ACHE
21 c1 inhibitor deficiency 10.1 SERPING1 SERPINA3
22 cutaneous solitary mastocytoma 10.0 SERPINA3 ENPP3
23 scrapie 10.0 SERPINA3 ACHE
24 toxic encephalopathy 10.0 SERPINA3 ACHE
25 allergic urticaria 10.0 SERPING1 FCER1A
26 amoxicillin allergy 10.0 FCER1A ENPP3
27 supranuclear palsy, progressive, 1 9.9 SERPINA3 ACHE
28 food allergy 9.9 HRH1 ENPP3
29 pfeiffer syndrome 9.9
30 vibratory urticaria 9.9
31 yemenite deaf-blind hypopigmentation syndrome 9.9
32 allergic rhinitis 9.9
33 chronic spontaneous urticaria 9.9
34 exercise-induced bronchoconstriction 9.9
35 common cold 9.9
36 miliaria rubra 9.9
37 miliaria 9.9
38 contact dermatitis 9.9
39 allergic contact dermatitis 9.9
40 rhinitis 9.9
41 autonomic dysfunction 9.9
42 fainting 9.9
43 seizure disorder 9.9
44 syncope 9.9
45 solar urticaria 9.9
46 sphingolipidosis 9.9 SERPINA3 ETFA
47 dermatographia 9.4 SERPING1 FCER1A ETFA ENPP3

Graphical network of the top 20 diseases related to Cholinergic Urticaria:



Diseases related to Cholinergic Urticaria

Symptoms & Phenotypes for Cholinergic Urticaria

Drugs & Therapeutics for Cholinergic Urticaria

Drugs for Cholinergic Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2 242138-07-4
2 Anti-Asthmatic Agents Phase 2
3 Respiratory System Agents Phase 2
4 Immunologic Factors Phase 2
5 Vaccines Phase 2
6 Immunoglobulins Phase 2
7 Anti-Allergic Agents Phase 2
8 Antibodies, Monoclonal Phase 2
9 Antibodies Phase 2
10 Cholinergic Agents Phase 2
11 Histamine Antagonists Phase 2
12 Histamine H1 Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Randomized, Double-blind, Placebo-controlled Parallel Clinical Trial to Assess Efficacy and Safety of Omalizumab (Xolair®) in a New Indication: Cholinergic Urticarial Completed NCT02012387 Phase 2
2 A Randomized, Double-blind, Placebo-controlled, Multicenter, 16-week Treatment Study With a 16 Week Follow-up Period to Assess the Efficacy and Safety of Dupilumab (Anti-IL4Ra) in Adult Patients With Cholinergic Urticaria Despite H1-antihistamine Treatment Recruiting NCT03749148 Phase 2 Dupilumab;Placebo
3 A Two-part Exploratory Study Combining a Pilot Study in Healthy Subjects and Chronic Spontaneous Urticaria Patients (Part 1) and a Randomized, Subject, Investigator and Sponsor-blinded, Placebo Controlled, Study (Part 2) to Assess the MechAniSm of acTion of ligElizumab (QGE031) in Patients With Chronic uRticaria (MASTER) Recruiting NCT04513548 Phase 1 Ligelizumab;Placebo

Search NIH Clinical Center for Cholinergic Urticaria

Genetic Tests for Cholinergic Urticaria

Anatomical Context for Cholinergic Urticaria

MalaCards organs/tissues related to Cholinergic Urticaria:

40
Skin

Publications for Cholinergic Urticaria

Articles related to Cholinergic Urticaria:

(show top 50) (show all 251)
# Title Authors PMID Year
1
Dupilumab use in dermatologic conditions beyond atopic dermatitis - a systematic review. 61
31693426 2021
2
Cholinergic synovitis: Description of four cases. 61
31708451 2021
3
Direct and indirect action modes of acetylcholine in cholinergic urticaria. 61
32565175 2021
4
Chronic inducible urticaria subtypes in children: Clinical features and prognosis. 61
32741017 2021
5
Omalizumab for cholinergic urticaria: 6 months prospective study and systematic review of the literature. 61
32654349 2020
6
A visual analogue scale for itch and pain in 23 cases of cholinergic urticaria. 61
32242985 2020
7
Omalizumab Treatment in Patients With Cholinergic Urticaria: A Real-World Retrospective Study in Korea. 61
32638568 2020
8
Chronic inducible urticaria: classification and prominent features of physical and non-physical types. 61
32975301 2020
9
[Treatment of simultaneously occurring urticaria and atopic dermatitis with dupilumab]. 61
32856123 2020
10
Regular sweating activities for the treatment of cholinergic urticaria with or without acquired idiopathic generalized anhidrosis. 61
32445244 2020
11
Clinical Management of Exercise-Induced Anaphylaxis and Cholinergic Urticaria. 61
32620433 2020
12
Clinical utility of the basophil activation test in the diagnosis of sweat allergy. 61
31615718 2020
13
Cholinergic urticaria with hypohidrosis successfully treated with omalizumab. 61
31663149 2020
14
Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020. 61
32224621 2020
15
Chronic inducible urticaria: confirmation through challenge tests and response to treatment. 61
32667419 2020
16
Cholinergic Urticaria: Clinical Presentation and Natural History in a Tropical Country. 61
32596363 2020
17
Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients. 61
32514333 2020
18
Clinico-epidemiological features of chronic urticaria in children: A retrospective analysis of 296 children from a tertiary care institute in Northern India. 61
30264742 2020
19
A case of cold-induced cholinergic urticaria accompanied by cholinergic urticaria showing a positive ice cube test. 61
31451337 2020
20
Real-life treatment of patients with cholinergic urticaria in German-speaking countries. 61
31765087 2019
21
Efficacy and Safety of Omalizumab (Xolair) for Cholinergic Urticaria in Patients Unresponsive to a Double Dose of Antihistamines: A Randomized Mixed Double-Blind and Open-Label Placebo-Controlled Clinical Trial. 61
30654196 2019
22
Angioedema frequently occurs in cholinergic urticaria. 61
30368007 2019
23
Epidemiology of urticaria including physical urticaria and angioedema in Korea. 61
29742892 2019
24
Real-life treatment of cholinergic urticaria with omalizumab. 61
30312709 2019
25
Exercise-induce anaphylaxis, food-dependent exercise-induce anaphylaxis, cholinergic urticaria and Kounis syndrome. 61
30774109 2019
26
Sweat allergy. 61
30075993 2018
27
How to Approach Chronic Inducible Urticaria. 61
30033913 2018
28
Chronic inducible urticaria: A systematic review of treatment options. 61
29438771 2018
29
Development and validation of the Cholinergic Urticaria Quality-of-Life Questionnaire (CholU-QoL). 61
29369455 2018
30
Cholinergic urticaria: epidemiology, physiopathology, new categorization, and management. 61
28382552 2018
31
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence. 61
28751232 2018
32
Successful treatment of refractory cholinergic urticaria with omalizumab. 61
29057464 2018
33
Cholinergic urticaria patients of different age groups have distinct features. 61
28873238 2017
34
Case of cholinergic urticaria accompanied by anaphylaxis. 61
28665007 2017
35
Cholinergic urticaria: More than a simple inducible urticaria. 61
27173142 2017
36
Aquagenic Urticaria: A Perplexing Physical Phenomenon. 61
29252177 2017
37
Cholinergic urticaria: Clinicoepidemiological paradigms from a tertiary care center in North India. 61
28731013 2017
38
Serum carcinoembryonic antigen specifically increases among various serum markers of adenocarcinoma in hypohidrosis or conditions related to hypohidrosis. 61
28295553 2017
39
A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration. 61
28108244 2017
40
Sweat allergy: Extrinsic or intrinsic? 61
28416076 2017
41
Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores. 61
28328088 2017
42
Elevation of serum carcinoembryonic antigen in a case of cholinergic urticaria with failed detection of hypohidrosis by the conventional starch-iodine test. 61
27864842 2017
43
Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases. 61
27876252 2017
44
Atopic predisposition in cholinergic urticaria patients and its implications. 61
27324252 2016
45
Clinical and etiologic evaluation of the children with chronic urticaria. 61
27931300 2016
46
Antihistamine updosing reduces disease activity in patients with difficult-to-treat cholinergic urticaria. 61
27496595 2016
47
Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review. 61
27585061 2016
48
Heat urticaria: a revision of published cases with an update on classification and management. 61
26973062 2016
49
Serum carcinoembryonic antigen (CEA) as a clinical marker in acquired idiopathic generalized anhidrosis: a close correlation between serum CEA level and disease activity. 61
26446433 2016
50
The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision. 61
26991006 2016

Variations for Cholinergic Urticaria

Expression for Cholinergic Urticaria

Search GEO for disease gene expression data for Cholinergic Urticaria.

Pathways for Cholinergic Urticaria

GO Terms for Cholinergic Urticaria

Cellular components related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 SERPING1 SERPINA3

Biological processes related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.26 HRH1 CHRM3
2 positive regulation of vasoconstriction GO:0045907 9.16 HRH1 CHRM3
3 G protein-coupled serotonin receptor signaling pathway GO:0098664 8.96 HRH1 CHRM3
4 acetylcholine receptor signaling pathway GO:0095500 8.62 CHRM3 ACHE

Molecular functions related to Cholinergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.16 HRH1 CHRM3
2 G protein-coupled serotonin receptor activity GO:0004993 8.96 HRH1 CHRM3
3 acetylcholine binding GO:0042166 8.62 CHRM3 ACHE

Sources for Cholinergic Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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