MCID: CHN003
MIFTS: 35

Chondroblastic Osteosarcoma

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Chondroblastic Osteosarcoma

MalaCards integrated aliases for Chondroblastic Osteosarcoma:

Name: Chondroblastic Osteosarcoma 12 55 15 73
Chondrosarcomatous Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3372
NCIt 50 C4021
SNOMED-CT 68 76312009
UMLS 73 C0279603

Summaries for Chondroblastic Osteosarcoma

MalaCards based summary : Chondroblastic Osteosarcoma, also known as chondrosarcomatous osteogenic sarcoma, is related to chondrosarcoma and interval angle-closure glaucoma, and has symptoms including pain An important gene associated with Chondroblastic Osteosarcoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are Citrate cycle (TCA cycle) and Peroxisome. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Chondroblastic Osteosarcoma

Diseases related to Chondroblastic Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 30.1 IDH1 IDH2
2 interval angle-closure glaucoma 10.4 IDH1 IDH2
3 adult oligodendroglioma 10.4 IDH1 IDH2
4 enchondroma 10.4 IDH1 IDH2
5 intracranial chondrosarcoma 10.3 IDH1 IDH2
6 cytogenetically normal acute myeloid leukemia 10.3 IDH1 IDH2
7 intraductal papilloma 10.3 IDH1 IDH2
8 multiple enchondromatosis, maffucci type 10.3 IDH1 IDH2
9 pilocytic astrocytoma of cerebellum 10.3 IDH1 IDH2
10 spindle cell hemangioma 10.3 IDH1 IDH2
11 periosteal chondrosarcoma 10.3 IDH1 IDH2
12 drug-induced mental disorder 10.3 IDH1 IDH2
13 drug psychosis 10.3 IDH1 IDH2
14 diffuse infiltrative lymphocytosis syndrome 10.2 IDH1 IDH2
15 2-hydroxyglutaric aciduria 10.2 IDH1 IDH2
16 breast papillary carcinoma 10.2 IDH1 IDH2
17 d-2-hydroxyglutaric aciduria 1 10.2 IDH1 IDH2
18 enchondromatosis, multiple, ollier type 10.2 IDH1 IDH2
19 spinal cord astrocytoma 10.1 H3F3A IDH1
20 bile duct adenocarcinoma 10.1 IDH1 IDH2
21 hepatitis 10.1
22 periosteal osteogenic sarcoma 10.0 BGLAP IDH1
23 intrahepatic cholangiocarcinoma 10.0 IDH1 IDH2
24 fibrous dysplasia 9.9
25 diphtheria 9.9
26 squamous cell carcinoma 9.9
27 suppurative periapical periodontitis 9.9
28 gliosarcoma 9.9
29 fibrosarcoma 9.9
30 meningitis 9.9
31 osteochondroma 9.9
32 chondromyxoid fibroma 9.9
33 oligodendroglioma 9.9 IDH1 IDH2
34 glioma susceptibility 1 9.8 H3F3A IDH1 IDH2
35 adult astrocytic tumour 9.8 H3F3A IDH1 IDH2
36 fibrillary astrocytoma 9.8 H3F3A IDH1 IDH2
37 undifferentiated pleomorphic sarcoma 9.8 EZR IDH1 IDH2
38 brain stem glioma 9.7 H3F3A IDH1 IDH2
39 giant cell tumor 9.7 BGLAP H3F3A
40 essential thrombocythemia 9.6 IDH1 IDH2
41 glioma 9.6 H3F3A IDH1 IDH2
42 glioblastoma 9.5 H3F3A IDH1 IDH2

Graphical network of the top 20 diseases related to Chondroblastic Osteosarcoma:



Diseases related to Chondroblastic Osteosarcoma

Symptoms & Phenotypes for Chondroblastic Osteosarcoma

UMLS symptoms related to Chondroblastic Osteosarcoma:


pain

GenomeRNAi Phenotypes related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.4 IDH1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.4 BGLAP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.4 NELL1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.4 BGLAP IDH1 NELL1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.4 BGLAP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.4 BGLAP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.4 NELL1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.4 NELL1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.4 NELL1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.4 NELL1

Drugs & Therapeutics for Chondroblastic Osteosarcoma

Drugs for Chondroblastic Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3 Anti-Allergic Agents Phase 3
4 Antipruritics Phase 3
5 Dermatologic Agents Phase 3
6 Gastrointestinal Agents Phase 3
7 Histamine Antagonists Phase 3
8 Histamine H1 Antagonists Phase 3
9
Histamine Phosphate Phase 3 51-74-1 65513
10 Neurotransmitter Agents Phase 3
11 Serotonin Agents Phase 3
12 Serotonin Antagonists Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
15 Angiogenesis Inhibitors Phase 2
16 Angiogenesis Modulating Agents Phase 2
17 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate

Search NIH Clinical Center for Chondroblastic Osteosarcoma

Genetic Tests for Chondroblastic Osteosarcoma

Anatomical Context for Chondroblastic Osteosarcoma

MalaCards organs/tissues related to Chondroblastic Osteosarcoma:

41
Bone, Breast, Lung

Publications for Chondroblastic Osteosarcoma

Articles related to Chondroblastic Osteosarcoma:

(show top 50) (show all 65)
# Title Authors Year
1
Pulmonary Metastases from Chondroblastic Osteosarcoma. ( 29641960 )
2018
2
Chondroblastic osteosarcoma mimicking periapical abscess. ( 28877285 )
2017
3
Chondroblastic osteosarcoma arising in the maxilla mimicking the radiographic and histological characteristics of cemento-osseous lesions: A case report. ( 28529749 )
2017
4
Unique Image Characteristics of an Occipital Primary Chondroblastic Osteosarcoma: A Rare Case Report and a Brief Literature Review. ( 28413767 )
2017
5
Chondroblastic osteosarcoma of the distal tibia: a rare case report. ( 28748013 )
2017
6
(68)Gallium-Arginine-Glycine-Aspartic Acid and (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Chondroblastic Osteosarcoma of the Skull. ( 28878856 )
2017
7
cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma. ( 28552607 )
2017
8
Chondroblastic osteosarcoma: Cytomorphologic characteristics and differential diagnosis on FNA. ( 26999748 )
2016
9
Chondroblastic osteosarcoma of breast in a case of phyllodes tumour with recurrence, a rare case report. ( 27639204 )
2016
10
Management of Pelvic Chondroblastic Osteosarcoma after Urgent Spinal Decompression - A Report of 2 Cases. ( 27299134 )
2016
11
A chondroblastic osteosarcoma of the coronoid process mimicking a fragmented coronoid process in a dog. ( 27118393 )
2016
12
Polyostotic Chondroblastic Osteosarcoma in a Kestrel ( Falco tinnunculus ). ( 26771323 )
2015
13
Chondroblastic osteosarcoma secondary to fibrosarcoma: A case report and literature review. ( 26788171 )
2015
14
Primary chondroblastic osteosarcoma of the breast. ( 26033758 )
2014
15
Chondroblastic osteosarcoma. ( 25949008 )
2014
16
Extraskeletal chondroblastic osteosarcoma in the left atrium. ( 25205782 )
2014
17
Chondroblastic osteosarcoma of the left zygomatic bone: Rare case report and review of the literature. ( 25328313 )
2014
18
Massive recurrent chondroblastic osteosarcoma of maxilla: a rare case report. ( 24596799 )
2014
19
Urinary bladder radiotherapy-related chondroblastic osteosarcoma: Rare case report and review of literature. ( 25125901 )
2014
20
Unusual case of chondroblastic osteosarcoma of the rib in an adult. ( 24887843 )
2013
21
Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations. ( 23598960 )
2013
22
Radiologic case study. Chondroblastic osteosarcoma and osteochondromas after prior total body irradiation. ( 24200424 )
2013
23
Pathology in practice. Primary hepatic chondroblastic osteosarcoma. ( 22515626 )
2012
24
Oral metastasis of chondroblastic osteosarcoma. ( 23293503 )
2012
25
Chondroblastic osteosarcoma of the temporal region: a diagnostic dilemma. ( 20730902 )
2011
26
Pathology in practice. Extraskeletal chondroblastic osteosarcoma. ( 21281210 )
2011
27
Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma. ( 20399482 )
2010
28
Hepatic extraskeletal chondroblastic osteosarcoma with unusual angioinvasion of the caudal vena cava in a dog. ( 21284251 )
2010
29
Meningeal chondroblastic osteosarcoma: case report and review of the literature. ( 20431908 )
2010
30
Chondroblastic osteosarcoma arising from the pleura: report of a case. ( 19997802 )
2009
31
[Post-radiation dedifferentiation of meningioma into chondroblastic osteosarcoma]. ( 19402318 )
2009
32
Characterization of chondroblastic osteosarcoma: gadolinium-enhanced versus diffusion-weighted MR imaging. ( 19306430 )
2009
33
Chondroblastic osteosarcoma of maxilla: a case report and review of literature. ( 23139529 )
2009
34
Imprint smear cytology of chondroblastic osteosarcoma: a case report. ( 19217054 )
2009
35
Tibial chondroblastic osteosarcoma--case report. ( 19218063 )
2009
36
Chondroblastic osteosarcoma of the cuboid: a literature review and report of a rare case. ( 19423044 )
2009
37
Ezrin immunohistochemical expression in cartilaginous tumours: a useful tool for differential diagnosis between chondroblastic osteosarcoma and chondrosarcoma. ( 19050913 )
2009
38
Different and identical features of chondroblastic osteosarcoma and chondrosarcoma: highlights on radiography and magnetic resonance imaging. ( 19251535 )
2009
39
Extraskeletal cutaneous chondroblastic osteosarcoma: a case report. ( 18190451 )
2008
40
Fatal pulmonary tumor embolism in a child with chondroblastic osteosarcoma. ( 17990913 )
2008
41
Primary chondroblastic osteosarcoma of the breast. Case report and review of the literature. ( 17308691 )
2006
42
Giant chondroblastic osteosarcoma of the chest wall. ( 16714710 )
2006
43
USCAP Specialty Conference, case 2: chondroblastic osteosarcoma with features resembling chondromyxoid fibroma. ( 15702366 )
2005
44
Chondroblastic osteosarcoma: scintigraphic appearance. ( 14734912 )
2004
45
Intraoperative TEE for the management of pulmonary tumour embolism during chondroblastic osteosarcoma resection. ( 14617583 )
2003
46
Malignant transformation of fibrous dysplasia into chondroblastic osteosarcoma. ( 11828332 )
2002
47
Intradural primary chondroblastic osteosarcoma: case report. ( 11733332 )
2001
48
A rare tumor of craniofacial bones in children: a pediatric chondroblastic osteosarcoma case with diagnostic and therapeutic problems. ( 11255734 )
2001
49
Chondroblastic osteosarcoma: case presentation. ( 11695148 )
2001
50
Fatal pulmonary tumor embolism caused by chondroblastic osteosarcoma. ( 10782142 )
2000

Variations for Chondroblastic Osteosarcoma

Expression for Chondroblastic Osteosarcoma

Search GEO for disease gene expression data for Chondroblastic Osteosarcoma.

Pathways for Chondroblastic Osteosarcoma

Pathways related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 IDH1 IDH2
2 10.87 IDH1 IDH2
3
Show member pathways
9.74 IDH1 IDH2

GO Terms for Chondroblastic Osteosarcoma

Cellular components related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 8.62 IDH1 IDH2

Biological processes related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.37 BGLAP IDH1
2 osteoblast differentiation GO:0001649 9.32 BGLAP H3F3A
3 tricarboxylic acid cycle GO:0006099 9.26 IDH1 IDH2
4 2-oxoglutarate metabolic process GO:0006103 9.16 IDH1 IDH2
5 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
6 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.26 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
3 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Chondroblastic Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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