MCID: CHN003
MIFTS: 30

Chondroblastic Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Chondroblastic Osteosarcoma

MalaCards integrated aliases for Chondroblastic Osteosarcoma:

Name: Chondroblastic Osteosarcoma 12 54 15 71
Chondrosarcomatous Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3372
NCIt 50 C4021
SNOMED-CT 67 76312009
UMLS 71 C0279603

Summaries for Chondroblastic Osteosarcoma

MalaCards based summary : Chondroblastic Osteosarcoma, also known as chondrosarcomatous osteogenic sarcoma, is related to chondrosarcoma and conventional central osteosarcoma, and has symptoms including pain An important gene associated with Chondroblastic Osteosarcoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), and among its related pathways/superpathways are Articular Cartilage Extracellular Matrix Pathway and Cell cycle_Chromosome condensation in prometaphase. Affiliated tissues include bone marrow, brain and breast.

Related Diseases for Chondroblastic Osteosarcoma

Diseases related to Chondroblastic Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 31.0 SERPINA3 IDH2 IDH1
2 conventional central osteosarcoma 30.1 SERPINA3 FAM180A
3 gliosarcoma 29.7 SERPINA3 IDH2 IDH1 H3-3A
4 bone giant cell tumor 29.7 SERPINA3 H3-3B H3-3A
5 chondroblastoma 29.7 SERPINA3 H3-3B H3-3A
6 osteogenic sarcoma 11.0
7 enchondroma 10.3 IDH2 IDH1
8 cytogenetically normal acute myeloid leukemia 10.3 IDH2 IDH1
9 intracranial chondrosarcoma 10.3 IDH2 IDH1
10 periosteal chondrosarcoma 10.3 IDH2 IDH1
11 gemistocytic astrocytoma 10.2 IDH2 IDH1
12 mixed oligodendroglioma-astrocytoma 10.2 IDH2 IDH1
13 mixed glioma 10.2 IDH2 IDH1
14 low grade glioma 10.2 IDH2 IDH1
15 cerebellar astrocytoma 10.2 SERPINA3 IDH1
16 spindle cell hemangioma 10.2 IDH2 IDH1
17 papillary cystadenocarcinoma 10.2 SERPINA3 BGLAP
18 fibroma 10.2
19 aphasia 10.2
20 extraosseous osteosarcoma 10.2
21 pulmonary embolism 10.2
22 rare tumor 10.2
23 tooth resorption 10.1 SERPINA3 BGLAP
24 odontogenic myxoma 10.1 SERPINA3 ACAN
25 bile duct adenocarcinoma 10.1 SERPINA3 IDH2 IDH1
26 juxtacortical chondroma 10.1 IDH2 IDH1 ENSG00000267640
27 hemarthrosis 10.1 BGLAP ACAN
28 trophoblastic neoplasm 10.0 SERPINA3 LGALS1
29 enchondromatosis, multiple, ollier type 10.0 IDH2 IDH1 ACAN
30 high grade ependymoma 10.0 IDH1 H3-3A
31 mccune-albright syndrome 10.0
32 chordoma 10.0
33 brittle bone disorder 10.0
34 meningioma, familial 10.0
35 osteofibrous dysplasia 10.0
36 cardiac arrest 10.0
37 fibrous dysplasia 10.0
38 spinal meningioma 10.0
39 hemopericardium 10.0
40 pericardial effusion 10.0
41 benign breast phyllodes tumor 10.0
42 cystitis 10.0
43 pericarditis 10.0
44 ossifying fibroma 10.0
45 hepatitis b 10.0
46 suppurative periapical periodontitis 10.0
47 pulmonary tuberculosis 10.0
48 mesenchymal cell neoplasm 10.0
49 fibrosarcoma 10.0
50 bladder urothelial carcinoma 10.0

Graphical network of the top 20 diseases related to Chondroblastic Osteosarcoma:



Diseases related to Chondroblastic Osteosarcoma

Symptoms & Phenotypes for Chondroblastic Osteosarcoma

UMLS symptoms related to Chondroblastic Osteosarcoma:


pain

Drugs & Therapeutics for Chondroblastic Osteosarcoma

Search Clinical Trials , NIH Clinical Center for Chondroblastic Osteosarcoma

Genetic Tests for Chondroblastic Osteosarcoma

Anatomical Context for Chondroblastic Osteosarcoma

MalaCards organs/tissues related to Chondroblastic Osteosarcoma:

40
Bone Marrow, Brain, Breast

Publications for Chondroblastic Osteosarcoma

Articles related to Chondroblastic Osteosarcoma:

(show top 50) (show all 181)
# Title Authors PMID Year
1
Intracardiac extension of chondroblastic osteosarcoma. 61
33176363 2021
2
Nomograms for predicting overall survival and cancer-specific survival of chondroblastic osteosarcoma patients. 61
32862456 2020
3
Novel RB1 and MET Gene Mutations in a Case with Bilateral Retinoblastoma Followed by Multiple Metastatic Osteosarcoma. 61
33375764 2020
4
Chondroblastic osteosarcoma-A case report and review of literature. 61
33235735 2020
5
[Application of rotationplasty in treatment of osteosarcoma of distal femur in children]. 61
33063482 2020
6
Clinical and Oncological Outcome of Chondroblastic Osteosarcoma: A Single Institutional Experience. 61
32850032 2020
7
Primary extraskeletal chondroblastic osteosarcoma of the pericardium: a case report and literature review. 61
32974450 2020
8
The Effect of Concurrent Stereotactic Body Radiation and Anti-PD-1 Therapy for Recurrent Metastatic Sarcoma. 61
32845986 2020
9
Successful endovascular removal of a chondroblastic osteosarcoma embolus within the left middle cerebral artery. 61
32675984 2020
10
PLK2 modulation of enriched TAp73 affects osteogenic differentiation and prognosis in human osteosarcoma. 61
32349184 2020
11
Intraoperative considerations in a patient with chondroblastic osteosarcoma and saddle pulmonary embolism undergoing amputation. 61
32577247 2020
12
Diagnostic Challenges in Chondroblastic Maxillary Osteosarcoma: A Case Report. 61
32642334 2020
13
Suspected Radiation-Induced Osteosarcoma in a Domestic Shorthair Cat. 61
31976121 2020
14
Primary Osteosarcoma of the Breast with Extensive Chondroid Matrix in a Teenager Female Patient: The Paradoxical Diagnosis in Breast Mastopathy. 61
32021493 2020
15
Conventional chondrosarcoma with focal clear cell change: a clinicopathological and molecular analysis. 61
31297850 2019
16
Primary osteosarcoma of the skull in teenager. 61
31527199 2019
17
Recurrent chondroblastic osteosarcoma of the right mandible subjected to photochemical internalization. 61
31252139 2019
18
Treatment outcome of patients with chondroblastic osteosarcoma of the limbs and pelvis. 61
31154835 2019
19
Aggressive chondroblastic osteosarcoma in a dog: A case report. 61
32206233 2019
20
Prognostic factors to survival of patients with chondroblastic osteosarcoma. 61
30278586 2018
21
Chondroblastic osteosarcoma of the middle ear in a guinea pig (Cavia porcellus). 61
30104775 2018
22
Sacral Osteosarcoma Masquerading as Posterior Thigh Pain. 61
30064331 2018
23
An Immunohistochemical Study of Stathmin 1 Expression in Osteosarcoma Shows an Association with Metastases and Poor Patient Prognosis. 61
30169496 2018
24
Pulmonary Metastases from Chondroblastic Osteosarcoma. 61
29641960 2018
25
Metastatic Sternal Osteosarcoma: A Rare Tumor. 61
29682436 2018
26
Prosthetic rehabilitation involving the use of implants following a fibula free flap reconstruction in the treatment of Osteosarcoma of the maxilla: a case report. 61
29209690 2017
27
68Gallium-Arginine-Glycine-Aspartic Acid and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Chondroblastic Osteosarcoma of the Skull. 61
28878856 2017
28
Correlation between apparent diffusion coefficient and histopathology subtypes of osteosarcoma after neoadjuvant chemotherapy. 61
27852643 2017
29
Chondroblastic osteosarcoma mimicking periapical abscess. 61
28877285 2017
30
cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma. 61
28552607 2017
31
Chondroblastoma: An Update. 61
28557595 2017
32
CD30 Expression in Pediatric Neoplasms, Study of 585 Cases. 61
28521633 2017
33
Chondroblastic osteosarcoma arising in the maxilla mimicking the radiographic and histological characteristics of cemento-osseous lesions: A case report. 61
28529749 2017
34
Unique Image Characteristics of an Occipital Primary Chondroblastic Osteosarcoma: A Rare Case Report and a Brief Literature Review. 61
28413767 2017
35
Chondroblastic osteosarcoma of the distal tibia: a rare case report. 61
28748013 2017
36
Chondroblastic and fibroblastic osteosarcoma of the jaws: Report of two cases and review of literature. 61
28393823 2017
37
Establishment and characterization of a novel osteosarcoma cell line: CHOS. 61
27017908 2016
38
The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing sarcomas and chondrosarcomas. 61
27465835 2016
39
Chondroblastic osteosarcoma: Cytomorphologic characteristics and differential diagnosis on FNA. 61
26999748 2016
40
A chondroblastic osteosarcoma of the coronoid process mimicking a fragmented coronoid process in a dog. 61
27118393 2016
41
[Atipic osteosarcoma in the femoral shaft case report and review of the literature]. 61
27627776 2016
42
Management of Pelvic Chondroblastic Osteosarcoma after Urgent Spinal Decompression - A Report of 2 Cases. 61
27299134 2016
43
Chondroblastic osteosarcoma of breast in a case of phyllodes tumour with recurrence, a rare case report. 61
27639204 2016
44
NELL-1 expression in tumors of cartilage. 61
27047227 2015
45
Chondroblastic osteosarcoma secondary to fibrosarcoma: A case report and literature review. 61
26788171 2015
46
Polyostotic Chondroblastic Osteosarcoma in a Kestrel ( Falco tinnunculus ). 61
26771323 2015
47
[Increased sclerosis of the iliac fossa: not at first glance a chondroblastic osteosarcoma of the pelvis]. 61
25750114 2015
48
ERG expression in chondrogenic bone and soft tissue tumours. 61
25378537 2015
49
Outcomes of the treatment of head and neck sarcomas in a tertiary referral center. 61
26042220 2015
50
Extraskeletal chondroblastic osteosarcoma in the left atrium. 61
25205782 2014

Variations for Chondroblastic Osteosarcoma

Expression for Chondroblastic Osteosarcoma

Search GEO for disease gene expression data for Chondroblastic Osteosarcoma.

Pathways for Chondroblastic Osteosarcoma

Pathways related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.71 MATN4 ACAN
2 10.47 H3-3B H3-3A
3
Show member pathways
9.74 IDH2 IDH1

GO Terms for Chondroblastic Osteosarcoma

Cellular components related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 SERPINA3 LGALS1 IDH2 IDH1 H3-3B H3-3A
2 collagen-containing extracellular matrix GO:0062023 9.46 SERPINA3 MATN4 LGALS1 ACAN
3 extracellular region GO:0005576 9.28 SERPINA3 MATN4 LGALS1 IDH1 H3-3B H3-3A
4 Barr body GO:0001740 8.96 H3-3B H3-3A

Biological processes related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.71 LGALS1 L2HGDH H3-3B H3-3A
2 osteoblast differentiation GO:0001649 9.65 H3-3B H3-3A BGLAP
3 embryo implantation GO:0007566 9.57 H3-3B H3-3A
4 chromatin silencing at rDNA GO:0000183 9.56 H3-3B H3-3A
5 tricarboxylic acid cycle GO:0006099 9.55 IDH2 IDH1
6 nucleus organization GO:0006997 9.54 H3-3B H3-3A
7 telomere organization GO:0032200 9.52 H3-3B H3-3A
8 DNA replication-independent nucleosome assembly GO:0006336 9.51 H3-3B H3-3A
9 muscle cell differentiation GO:0042692 9.49 H3-3B H3-3A
10 NADP metabolic process GO:0006739 9.46 IDH2 IDH1
11 isocitrate metabolic process GO:0006102 9.43 IDH2 IDH1
12 pericentric heterochromatin assembly GO:0031508 9.37 H3-3B H3-3A
13 regulation of centromere complex assembly GO:0090230 9.32 H3-3B H3-3A
14 negative regulation of chromosome condensation GO:1902340 9.26 H3-3B H3-3A
15 telomeric heterochromatin assembly GO:0031509 9.16 H3-3B H3-3A
16 glyoxylate cycle GO:0006097 8.96 IDH2 IDH1
17 2-oxoglutarate metabolic process GO:0006103 8.8 L2HGDH IDH2 IDH1

Molecular functions related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 9.32 H3-3B H3-3A
2 NAD binding GO:0051287 9.26 IDH2 IDH1
3 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.16 H3-3B H3-3A
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Chondroblastic Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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