MCID: CHN003
MIFTS: 31

Chondroblastic Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Chondroblastic Osteosarcoma

MalaCards integrated aliases for Chondroblastic Osteosarcoma:

Name: Chondroblastic Osteosarcoma 12 54 15 71
Chondrosarcomatous Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3372
NCIt 49 C4021
SNOMED-CT 67 76312009
UMLS 71 C0279603

Summaries for Chondroblastic Osteosarcoma

MalaCards based summary : Chondroblastic Osteosarcoma, also known as chondrosarcomatous osteogenic sarcoma, is related to chondrosarcoma and meningioma, familial, and has symptoms including pain An important gene associated with Chondroblastic Osteosarcoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), and among its related pathways/superpathways are Articular Cartilage Extracellular Matrix Pathway and Cell cycle_Chromosome condensation in prometaphase. Affiliated tissues include bone, breast and brain.

Related Diseases for Chondroblastic Osteosarcoma

Diseases related to Chondroblastic Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 31.1 SERPINA3 IDH2 IDH1
2 meningioma, familial 29.8 SERPINA3 IDH1 EZR
3 bone giant cell tumor 29.7 SERPINA3 H3-3B H3-3A
4 chondroblastoma 29.7 SERPINA3 H3-3B H3-3A
5 giant cell tumor 29.4 SERPINA3 H3-3B H3-3A BGLAP
6 gliosarcoma 29.1 SERPINA3 IDH2 IDH1 H3-3B H3-3A
7 osteogenic sarcoma 11.0
8 enchondroma 10.4 IDH2 IDH1
9 breast duct papilloma 10.4 IDH2 IDH1
10 cytogenetically normal acute myeloid leukemia 10.4 IDH2 IDH1
11 intracranial chondrosarcoma 10.4 IDH2 IDH1
12 central nervous system rhabdomyosarcoma 10.4 IDH2 IDH1
13 periosteal chondrosarcoma 10.4 IDH2 IDH1
14 breast hemangioma 10.4 IDH2 IDH1
15 spinal cord oligodendroglioma 10.3 IDH2 IDH1
16 interval angle-closure glaucoma 10.3 IDH2 IDH1
17 gemistocytic astrocytoma 10.3 IDH2 IDH1
18 intraductal breast neoplasm 10.3 IDH2 IDH1
19 mixed glioma 10.3 IDH2 IDH1
20 intraductal papilloma 10.3 IDH2 IDH1
21 multiple enchondromatosis, maffucci type 10.3 IDH2 IDH1
22 extraosseous osteosarcoma 10.2
23 rare tumor 10.2
24 spindle cell hemangioma 10.2 IDH2 IDH1
25 cerebral ventricle cancer 10.2 IDH2 IDH1
26 cerebrum cancer 10.2 IDH2 IDH1
27 papillary cystadenocarcinoma 10.2 SERPINA3 BGLAP
28 undifferentiated pleomorphic sarcoma 10.2 IDH2 IDH1 EZR
29 d-2-hydroxyglutaric aciduria 1 10.2 IDH2 IDH1
30 2-hydroxyglutaric aciduria 10.2 IDH2 IDH1
31 trophoblastic neoplasm 10.2 SERPINA3 LGALS1
32 cerebellum cancer 10.1 SERPINA3 IDH2 IDH1
33 localized chondrosarcoma 10.1 IDH2 ACAN
34 l-2-hydroxyglutaric aciduria 10.1 IDH2 IDH1
35 thoracic benign neoplasm 10.1 SERPINA3 IDH2 IDH1
36 breast benign neoplasm 10.1 SERPINA3 IDH2 IDH1
37 mccune-albright syndrome 10.1
38 chordoma 10.1
39 brittle bone disorder 10.1
40 meningioma, radiation-induced 10.1
41 osteofibrous dysplasia 10.1
42 fibroma 10.1
43 aphasia 10.1
44 cardiac arrest 10.1
45 fibrous dysplasia 10.1
46 spinal meningioma 10.1
47 benign breast phyllodes tumor 10.1
48 cystitis 10.1
49 hepatitis b 10.1
50 suppurative periapical periodontitis 10.1

Graphical network of the top 20 diseases related to Chondroblastic Osteosarcoma:



Diseases related to Chondroblastic Osteosarcoma

Symptoms & Phenotypes for Chondroblastic Osteosarcoma

UMLS symptoms related to Chondroblastic Osteosarcoma:


pain

Drugs & Therapeutics for Chondroblastic Osteosarcoma

Search Clinical Trials , NIH Clinical Center for Chondroblastic Osteosarcoma

Genetic Tests for Chondroblastic Osteosarcoma

Anatomical Context for Chondroblastic Osteosarcoma

MalaCards organs/tissues related to Chondroblastic Osteosarcoma:

40
Bone, Breast, Brain, Spinal Cord, Cerebellum, Lung, Bone Marrow

Publications for Chondroblastic Osteosarcoma

Articles related to Chondroblastic Osteosarcoma:

(show top 50) (show all 168)
# Title Authors PMID Year
1
Suspected Radiation-Induced Osteosarcoma in a Domestic Shorthair Cat. 61
31976121 2020
2
Primary Osteosarcoma of the Breast with Extensive Chondroid Matrix in a Teenager Female Patient: The Paradoxical Diagnosis in Breast Mastopathy. 61
32021493 2020
3
Conventional chondrosarcoma with focal clear cell change: a clinicopathological and molecular analysis. 61
31297850 2019
4
Primary osteosarcoma of the skull in teenager. 61
31527199 2019
5
Recurrent chondroblastic osteosarcoma of the right mandible subjected to photochemical internalization. 61
31252139 2019
6
Treatment outcome of patients with chondroblastic osteosarcoma of the limbs and pelvis. 61
31154835 2019
7
Prognostic factors to survival of patients with chondroblastic osteosarcoma. 61
30278586 2018
8
Sacral Osteosarcoma Masquerading as Posterior Thigh Pain. 61
30064331 2018
9
Chondroblastic osteosarcoma of the middle ear in a guinea pig (Cavia porcellus). 61
30104775 2018
10
An Immunohistochemical Study of Stathmin 1 Expression in Osteosarcoma Shows an Association with Metastases and Poor Patient Prognosis. 61
30169496 2018
11
Pulmonary Metastases from Chondroblastic Osteosarcoma. 61
29641960 2018
12
Metastatic Sternal Osteosarcoma: A Rare Tumor. 61
29682436 2018
13
Prosthetic rehabilitation involving the use of implants following a fibula free flap reconstruction in the treatment of Osteosarcoma of the maxilla: a case report. 61
29209690 2017
14
68Gallium-Arginine-Glycine-Aspartic Acid and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Chondroblastic Osteosarcoma of the Skull. 61
28878856 2017
15
Correlation between apparent diffusion coefficient and histopathology subtypes of osteosarcoma after neoadjuvant chemotherapy. 61
27852643 2017
16
Chondroblastic osteosarcoma mimicking periapical abscess. 61
28877285 2017
17
Chondroblastoma: An Update. 61
28557595 2017
18
CD30 Expression in Pediatric Neoplasms, Study of 585 Cases. 61
28521633 2017
19
cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma. 61
28552607 2017
20
Chondroblastic osteosarcoma arising in the maxilla mimicking the radiographic and histological characteristics of cemento-osseous lesions: A case report. 61
28529749 2017
21
Unique Image Characteristics of an Occipital Primary Chondroblastic Osteosarcoma: A Rare Case Report and a Brief Literature Review. 61
28413767 2017
22
Chondroblastic and fibroblastic osteosarcoma of the jaws: Report of two cases and review of literature. 61
28393823 2017
23
Chondroblastic osteosarcoma of the distal tibia: a rare case report. 61
28748013 2017
24
Establishment and characterization of a novel osteosarcoma cell line: CHOS. 61
27017908 2016
25
The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing sarcomas and chondrosarcomas. 61
27465835 2016
26
Chondroblastic osteosarcoma: Cytomorphologic characteristics and differential diagnosis on FNA. 61
26999748 2016
27
A chondroblastic osteosarcoma of the coronoid process mimicking a fragmented coronoid process in a dog. 61
27118393 2016
28
Management of Pelvic Chondroblastic Osteosarcoma after Urgent Spinal Decompression - A Report of 2 Cases. 61
27299134 2016
29
[Atipic osteosarcoma in the femoral shaft case report and review of the literature]. 61
27627776 2016
30
Chondroblastic osteosarcoma of breast in a case of phyllodes tumour with recurrence, a rare case report. 61
27639204 2016
31
Chondroblastic osteosarcoma secondary to fibrosarcoma: A case report and literature review. 61
26788171 2015
32
NELL-1 expression in tumors of cartilage. 61
27047227 2015
33
Polyostotic Chondroblastic Osteosarcoma in a Kestrel ( Falco tinnunculus ). 61
26771323 2015
34
[Increased sclerosis of the iliac fossa: not at first glance a chondroblastic osteosarcoma of the pelvis]. 61
25750114 2015
35
ERG expression in chondrogenic bone and soft tissue tumours. 61
25378537 2015
36
Outcomes of the treatment of head and neck sarcomas in a tertiary referral center. 61
26042220 2015
37
Extraskeletal chondroblastic osteosarcoma in the left atrium. 61
25205782 2014
38
Chondrosarcomas of the head and neck. 61
24213203 2014
39
Chondroblastic osteosarcoma. 61
25949008 2014
40
Diagnosis and treatment of low-grade osteosarcoma: experience with nine cases. 61
23881556 2014
41
Unusual case of chondroblastic osteosarcoma of the rib in an adult. 61
24887843 2014
42
Urinary bladder radiotherapy-related chondroblastic osteosarcoma: Rare case report and review of literature. 61
25125901 2014
43
Chondroblastic osteosarcoma of the left zygomatic bone: Rare case report and review of the literature. 61
25328313 2014
44
Periosteal osteosarcoma arising from the rib and scapula: imaging features in two cases. 61
24843242 2014
45
Research findings working with the p53 and Rb1 targeted osteosarcoma mouse model. 61
24959378 2014
46
Primary chondroblastic osteosarcoma of the breast. 61
26033758 2014
47
Massive recurrent chondroblastic osteosarcoma of maxilla: a rare case report. 61
24596799 2014
48
Radiologic case study. Chondroblastic osteosarcoma and osteochondromas after prior total body irradiation. 61
24200424 2013
49
Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed. 61
24156349 2013
50
Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations. 61
23598960 2013

Variations for Chondroblastic Osteosarcoma

Expression for Chondroblastic Osteosarcoma

Search GEO for disease gene expression data for Chondroblastic Osteosarcoma.

Pathways for Chondroblastic Osteosarcoma

Pathways related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.71 MATN4 ACAN
2 10.47 H3-3B H3-3A
3
Show member pathways
9.74 IDH2 IDH1

GO Terms for Chondroblastic Osteosarcoma

Cellular components related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 SERPINA3 LGALS1 IDH2 IDH1 H3-3B H3-3A
2 collagen-containing extracellular matrix GO:0062023 9.56 SERPINA3 MATN4 LGALS1 ACAN
3 nuclear nucleosome GO:0000788 9.32 H3-3B H3-3A
4 extracellular region GO:0005576 9.28 SERPINA3 MATN4 LGALS1 IDH1 H3-3B H3-3A
5 Barr body GO:0001740 8.96 H3-3B H3-3A

Biological processes related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.74 LGALS1 H3-3B H3-3A
2 osteoblast differentiation GO:0001649 9.61 H3-3B H3-3A BGLAP
3 embryo implantation GO:0007566 9.58 H3-3B H3-3A
4 chromatin silencing at rDNA GO:0000183 9.56 H3-3B H3-3A
5 oogenesis GO:0048477 9.55 H3-3B H3-3A
6 tricarboxylic acid cycle GO:0006099 9.54 IDH2 IDH1
7 nucleus organization GO:0006997 9.52 H3-3B H3-3A
8 telomere organization GO:0032200 9.51 H3-3B H3-3A
9 DNA replication-independent nucleosome assembly GO:0006336 9.49 H3-3B H3-3A
10 muscle cell differentiation GO:0042692 9.48 H3-3B H3-3A
11 2-oxoglutarate metabolic process GO:0006103 9.46 IDH2 IDH1
12 NADP metabolic process GO:0006739 9.4 IDH2 IDH1
13 isocitrate metabolic process GO:0006102 9.37 IDH2 IDH1
14 pericentric heterochromatin assembly GO:0031508 9.32 H3-3B H3-3A
15 regulation of centromere complex assembly GO:0090230 9.26 H3-3B H3-3A
16 negative regulation of chromosome condensation GO:1902340 9.16 H3-3B H3-3A
17 telomeric heterochromatin assembly GO:0031509 8.96 H3-3B H3-3A
18 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 9.37 H3-3B H3-3A
2 NAD binding GO:0051287 9.32 IDH2 IDH1
3 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.26 H3-3B H3-3A
4 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH2 IDH1
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
6 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Chondroblastic Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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