MCID: CHN003
MIFTS: 35

Chondroblastic Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Chondroblastic Osteosarcoma

MalaCards integrated aliases for Chondroblastic Osteosarcoma:

Name: Chondroblastic Osteosarcoma 12 56 15 74
Chondrosarcomatous Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3372
NCIt 51 C4021
SNOMED-CT 69 76312009
UMLS 74 C0279603

Summaries for Chondroblastic Osteosarcoma

MalaCards based summary : Chondroblastic Osteosarcoma, also known as chondrosarcomatous osteogenic sarcoma, is related to chondrosarcoma and osteogenic sarcoma, and has symptoms including pain An important gene associated with Chondroblastic Osteosarcoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are Citrate cycle (TCA cycle) and Peroxisome. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Chondroblastic Osteosarcoma

Diseases related to Chondroblastic Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 30.9 IDH1 IDH2
2 osteogenic sarcoma 10.7
3 interval angle-closure glaucoma 10.2 IDH1 IDH2
4 adult oligodendroglioma 10.2 IDH1 IDH2
5 oligodendroglioma 10.2 IDH1 IDH2
6 enchondroma 10.2 IDH1 IDH2
7 intracranial chondrosarcoma 10.2 IDH1 IDH2
8 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
9 multiple enchondromatosis, maffucci type 10.2 IDH1 IDH2
10 intraductal papilloma 10.2 IDH1 IDH2
11 pilocytic astrocytoma of cerebellum 10.2 IDH1 IDH2
12 spindle cell hemangioma 10.2 IDH1 IDH2
13 periosteal chondrosarcoma 10.2 IDH1 IDH2
14 glioma susceptibility 1 10.1 IDH1 IDH2
15 adult astrocytic tumour 10.1 IDH1 IDH2
16 fibrillary astrocytoma 10.1 IDH1 IDH2
17 diffuse infiltrative lymphocytosis syndrome 10.1 IDH1 IDH2
18 drug-induced mental disorder 10.1 IDH1 IDH2
19 fibroma 10.1
20 fibrous dysplasia 10.1
21 squamous cell carcinoma 10.1
22 suppurative periapical periodontitis 10.1
23 gliosarcoma 10.1
24 fibrosarcoma 10.1
25 chondromyxoid fibroma 10.1
26 drug psychosis 10.1 IDH1 IDH2
27 2-hydroxyglutaric aciduria 10.1 IDH1 IDH2
28 d-2-hydroxyglutaric aciduria 1 10.1 IDH1 IDH2
29 bile duct adenocarcinoma 10.1 IDH1 IDH2
30 enchondromatosis, multiple, ollier type 10.1 IDH1 IDH2
31 brain stem glioma 10.1 IDH1 IDH2
32 supratentorial cancer 10.1 IDH1 IDH2
33 cerebrum cancer 10.0 IDH1 IDH2
34 central nervous system cancer 10.0 IDH1 IDH2
35 inflammatory mfh 10.0 EZR SERPINA3
36 nervous system cancer 10.0 IDH1 IDH2
37 periosteal osteogenic sarcoma 9.9 BGLAP IDH1
38 intrahepatic cholangiocarcinoma 9.9 IDH1 IDH2
39 undifferentiated pleomorphic sarcoma 9.9 EZR IDH1 IDH2
40 fibrosarcomatous osteosarcoma 9.9 BGLAP NELL1
41 extraskeletal chondroma 9.8 BGLAP SERPINA3
42 essential thrombocythemia 9.8 IDH1 IDH2
43 giant cell tumor 9.6 BGLAP SERPINA3

Graphical network of the top 20 diseases related to Chondroblastic Osteosarcoma:



Diseases related to Chondroblastic Osteosarcoma

Symptoms & Phenotypes for Chondroblastic Osteosarcoma

UMLS symptoms related to Chondroblastic Osteosarcoma:


pain

GenomeRNAi Phenotypes related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.4 IDH1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.4 BGLAP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.4 NELL1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.4 BGLAP IDH1 NELL1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.4 BGLAP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.4 BGLAP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.4 NELL1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.4 NELL1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.4 NELL1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.4 NELL1

Drugs & Therapeutics for Chondroblastic Osteosarcoma

Drugs for Chondroblastic Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Histamine Antagonists Phase 3
4 Neurotransmitter Agents Phase 3
5 Gastrointestinal Agents Phase 3
6 Serotonin Agents Phase 3
7 Serotonin Antagonists Phase 3
8 Anti-Allergic Agents Phase 3
9 Antipruritics Phase 3
10 Dermatologic Agents Phase 3
11 Histamine H1 Antagonists Phase 3
12
Histamine Phosphate Phase 3 51-74-1 65513
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
15 Angiogenesis Modulating Agents Phase 2
16 Angiogenesis Inhibitors Phase 2
17 Immunosuppressive Agents Phase 2
18 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate

Search NIH Clinical Center for Chondroblastic Osteosarcoma

Genetic Tests for Chondroblastic Osteosarcoma

Anatomical Context for Chondroblastic Osteosarcoma

MalaCards organs/tissues related to Chondroblastic Osteosarcoma:

42
Bone, Breast, Lung, Brain, Myeloid, Cerebellum

Publications for Chondroblastic Osteosarcoma

Articles related to Chondroblastic Osteosarcoma:

(show top 50) (show all 68)
# Title Authors Year
1
Pulmonary Metastases from Chondroblastic Osteosarcoma. ( 29641960 )
2018
2
Chondroblastic osteosarcoma of the middle ear in a guinea pig (Cavia porcellus). ( 30104775 )
2018
3
Prognostic factors to survival of patients with chondroblastic osteosarcoma. ( 30278586 )
2018
4
Unique Image Characteristics of an Occipital Primary Chondroblastic Osteosarcoma: A Rare Case Report and a Brief Literature Review. ( 28413767 )
2017
5
Chondroblastic osteosarcoma arising in the maxilla mimicking the radiographic and histological characteristics of cemento-osseous lesions: A case report. ( 28529749 )
2017
6
cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma. ( 28552607 )
2017
7
Chondroblastic osteosarcoma of the distal tibia: a rare case report. ( 28748013 )
2017
8
Chondroblastic osteosarcoma mimicking periapical abscess. ( 28877285 )
2017
9
68Gallium-Arginine-Glycine-Aspartic Acid and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Chondroblastic Osteosarcoma of the Skull. ( 28878856 )
2017
10
Chondroblastic osteosarcoma: Cytomorphologic characteristics and differential diagnosis on FNA. ( 26999748 )
2016
11
A chondroblastic osteosarcoma of the coronoid process mimicking a fragmented coronoid process in a dog. ( 27118393 )
2016
12
Management of Pelvic Chondroblastic Osteosarcoma after Urgent Spinal Decompression - A Report of 2 Cases. ( 27299134 )
2016
13
Chondroblastic osteosarcoma of breast in a case of phyllodes tumour with recurrence, a rare case report. ( 27639204 )
2016
14
Polyostotic Chondroblastic Osteosarcoma in a Kestrel ( Falco tinnunculus ). ( 26771323 )
2015
15
Chondroblastic osteosarcoma secondary to fibrosarcoma: A case report and literature review. ( 26788171 )
2015
16
Massive recurrent chondroblastic osteosarcoma of maxilla: a rare case report. ( 24596799 )
2014
17
Unusual case of chondroblastic osteosarcoma of the rib in an adult. ( 24887843 )
2014
18
Urinary bladder radiotherapy-related chondroblastic osteosarcoma: Rare case report and review of literature. ( 25125901 )
2014
19
Extraskeletal chondroblastic osteosarcoma in the left atrium. ( 25205782 )
2014
20
Chondroblastic osteosarcoma of the left zygomatic bone: Rare case report and review of the literature. ( 25328313 )
2014
21
Chondroblastic osteosarcoma. ( 25949008 )
2014
22
Primary chondroblastic osteosarcoma of the breast. ( 26033758 )
2014
23
Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations. ( 23598960 )
2013
24
Radiologic case study. Chondroblastic osteosarcoma and osteochondromas after prior total body irradiation. ( 24200424 )
2013
25
Pathology in practice. Primary hepatic chondroblastic osteosarcoma. ( 22515626 )
2012
26
Oral metastasis of chondroblastic osteosarcoma. ( 23293503 )
2012
27
Chondroblastic osteosarcoma of the temporal region: a diagnostic dilemma. ( 20730902 )
2011
28
Pathology in practice. Extraskeletal chondroblastic osteosarcoma. ( 21281210 )
2011
29
Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma. ( 20399482 )
2010
30
Meningeal chondroblastic osteosarcoma: case report and review of the literature. ( 20431908 )
2010
31
Hepatic extraskeletal chondroblastic osteosarcoma with unusual angioinvasion of the caudal vena cava in a dog. ( 21284251 )
2010
32
Ezrin immunohistochemical expression in cartilaginous tumours: a useful tool for differential diagnosis between chondroblastic osteosarcoma and chondrosarcoma. ( 19050913 )
2009
33
Imprint smear cytology of chondroblastic osteosarcoma: a case report. ( 19217054 )
2009
34
Tibial chondroblastic osteosarcoma--case report. ( 19218063 )
2009
35
Different and identical features of chondroblastic osteosarcoma and chondrosarcoma: highlights on radiography and magnetic resonance imaging. ( 19251535 )
2009
36
Characterization of chondroblastic osteosarcoma: gadolinium-enhanced versus diffusion-weighted MR imaging. ( 19306430 )
2009
37
Chondroblastic osteosarcoma of the cuboid: a literature review and report of a rare case. ( 19423044 )
2009
38
Chondroblastic osteosarcoma arising from the pleura: report of a case. ( 19997802 )
2009
39
Chondroblastic osteosarcoma of maxilla: a case report and review of literature. ( 23139529 )
2009
40
[Post-radiation dedifferentiation of meningioma into chondroblastic osteosarcoma]. ( 19402318 )
2009
41
Fatal pulmonary tumor embolism in a child with chondroblastic osteosarcoma. ( 17990913 )
2008
42
Extraskeletal cutaneous chondroblastic osteosarcoma: a case report. ( 18190451 )
2008
43
Giant chondroblastic osteosarcoma of the chest wall. ( 16714710 )
2006
44
Primary chondroblastic osteosarcoma of the breast. Case report and review of the literature. ( 17308691 )
2006
45
USCAP Specialty Conference, case 2: chondroblastic osteosarcoma with features resembling chondromyxoid fibroma. ( 15702366 )
2005
46
Chondroblastic osteosarcoma: scintigraphic appearance. ( 14734912 )
2004
47
Intraoperative TEE for the management of pulmonary tumour embolism during chondroblastic osteosarcoma resection. ( 14617583 )
2003
48
Malignant transformation of fibrous dysplasia into chondroblastic osteosarcoma. ( 11828332 )
2002
49
A rare tumor of craniofacial bones in children: a pediatric chondroblastic osteosarcoma case with diagnostic and therapeutic problems. ( 11255734 )
2001
50
Chondroblastic osteosarcoma: case presentation. ( 11695148 )
2001

Variations for Chondroblastic Osteosarcoma

Expression for Chondroblastic Osteosarcoma

Search GEO for disease gene expression data for Chondroblastic Osteosarcoma.

Pathways for Chondroblastic Osteosarcoma

Pathways related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 IDH1 IDH2
2 10.87 IDH1 IDH2
3
Show member pathways
9.74 IDH1 IDH2

GO Terms for Chondroblastic Osteosarcoma

Cellular components related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 8.96 IDH1 IDH2
2 secretory granule lumen GO:0034774 8.62 IDH1 SERPINA3

Biological processes related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.37 BGLAP IDH1
2 tricarboxylic acid cycle GO:0006099 9.32 IDH1 IDH2
3 2-oxoglutarate metabolic process GO:0006103 9.26 IDH1 IDH2
4 NADP metabolic process GO:0006739 9.16 IDH1 IDH2
5 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
6 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.26 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
3 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
4 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Chondroblastic Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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