MCID: CHN003
MIFTS: 29

Chondroblastic Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Chondroblastic Osteosarcoma

MalaCards integrated aliases for Chondroblastic Osteosarcoma:

Name: Chondroblastic Osteosarcoma 12 54 15 71
Chondrosarcomatous Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3372
NCIt 49 C4021
SNOMED-CT 67 76312009
UMLS 71 C0279603

Summaries for Chondroblastic Osteosarcoma

MalaCards based summary : Chondroblastic Osteosarcoma, also known as chondrosarcomatous osteogenic sarcoma, is related to chondrosarcoma and conventional central osteosarcoma, and has symptoms including pain An important gene associated with Chondroblastic Osteosarcoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), and among its related pathways/superpathways are Central carbon metabolism in cancer and Cytosine methylation. Affiliated tissues include bone, breast and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Chondroblastic Osteosarcoma

Diseases related to Chondroblastic Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 31.2 SERPINA3 IDH2 IDH1
2 conventional central osteosarcoma 30.5 SERPINA3 FAM180A
3 embryonal sarcoma 30.0 TP53 SERPINA3
4 gliosarcoma 29.5 TP53 SERPINA3 IDH2 IDH1
5 meningioma, familial 29.5 TP53 SERPINA3 IDH1 EZR
6 osteogenic sarcoma 11.1
7 enchondroma 10.4 IDH2 IDH1
8 breast intraductal papillomatosis 10.4 IDH2 IDH1
9 intraductal papilloma 10.4 IDH2 IDH1
10 breast duct papilloma 10.4 IDH2 IDH1
11 breast papillomatosis 10.4 IDH2 IDH1
12 adult brain stem glioma 10.4 IDH2 IDH1
13 cytogenetically normal acute myeloid leukemia 10.4 IDH2 IDH1
14 intracranial chondrosarcoma 10.4 IDH2 IDH1
15 periosteal chondrosarcoma 10.4 IDH2 IDH1
16 adult oligodendroglioma 10.4 IDH2 IDH1
17 childhood oligodendroglioma 10.4 IDH2 IDH1
18 interval angle-closure glaucoma 10.4 IDH2 IDH1
19 intraductal breast benign neoplasm 10.4 IDH2 IDH1
20 cerebellar astrocytoma 10.3 SERPINA3 IDH1
21 spindle cell hemangioma 10.3 IDH2 IDH1
22 clear cell chondrosarcoma 10.3 SERPINA3 IDH1
23 multiple enchondromatosis, maffucci type 10.3 IDH2 IDH1
24 papillary cystadenocarcinoma 10.3 SERPINA3 BGLAP
25 extraosseous osteosarcoma 10.3
26 pulmonary embolism 10.3
27 rare tumor 10.3
28 bone benign neoplasm 10.2 SERPINA3 BGLAP
29 tooth resorption 10.2 SERPINA3 BGLAP
30 d-2-hydroxyglutaric aciduria 1 10.2 IDH2 IDH1
31 odontogenic myxoma 10.1 SERPINA3 ACAN
32 hemarthrosis 10.1 BGLAP ACAN
33 mccune-albright syndrome 10.1
34 chordoma 10.1
35 brittle bone disorder 10.1
36 meningioma, radiation-induced 10.1
37 osteofibrous dysplasia 10.1
38 fibroma 10.1
39 aphasia 10.1
40 cardiac arrest 10.1
41 fibrous dysplasia 10.1
42 spinal meningioma 10.1
43 benign breast phyllodes tumor 10.1
44 cystitis 10.1
45 hepatitis b 10.1
46 suppurative periapical periodontitis 10.1
47 chondroblastoma 10.1
48 mesenchymal cell neoplasm 10.1
49 fibrosarcoma 10.1
50 bladder urothelial carcinoma 10.1

Graphical network of the top 20 diseases related to Chondroblastic Osteosarcoma:



Diseases related to Chondroblastic Osteosarcoma

Symptoms & Phenotypes for Chondroblastic Osteosarcoma

UMLS symptoms related to Chondroblastic Osteosarcoma:


pain

GenomeRNAi Phenotypes related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.23 NELL1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.23 BGLAP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.23 IDH1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.23 BGLAP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.23 BGLAP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.23 BGLAP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.23 NELL1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-47 9.23 IDH1

Drugs & Therapeutics for Chondroblastic Osteosarcoma

Search Clinical Trials , NIH Clinical Center for Chondroblastic Osteosarcoma

Genetic Tests for Chondroblastic Osteosarcoma

Anatomical Context for Chondroblastic Osteosarcoma

MalaCards organs/tissues related to Chondroblastic Osteosarcoma:

40
Bone, Breast, Lung, Bone Marrow, Brain

Publications for Chondroblastic Osteosarcoma

Articles related to Chondroblastic Osteosarcoma:

(show top 50) (show all 171)
# Title Authors PMID Year
1
PLK2 modulation of enriched TAp73 affects osteogenic differentiation and prognosis in human osteosarcoma. 61
32349184 2020
2
Intraoperative considerations in a patient with chondroblastic osteosarcoma and saddle pulmonary embolism undergoing amputation. 61
32577247 2020
3
Primary Osteosarcoma of the Breast with Extensive Chondroid Matrix in a Teenager Female Patient: The Paradoxical Diagnosis in Breast Mastopathy. 61
32021493 2020
4
Suspected Radiation-Induced Osteosarcoma in a Domestic Shorthair Cat. 61
31976121 2020
5
Conventional chondrosarcoma with focal clear cell change: a clinicopathological and molecular analysis. 61
31297850 2019
6
Primary osteosarcoma of the skull in teenager. 61
31527199 2019
7
Recurrent chondroblastic osteosarcoma of the right mandible subjected to photochemical internalization. 61
31252139 2019
8
Treatment outcome of patients with chondroblastic osteosarcoma of the limbs and pelvis. 61
31154835 2019
9
Aggressive chondroblastic osteosarcoma in a dog: A case report. 61
32206233 2019
10
Prognostic factors to survival of patients with chondroblastic osteosarcoma. 61
30278586 2018
11
Sacral Osteosarcoma Masquerading as Posterior Thigh Pain. 61
30064331 2018
12
Chondroblastic osteosarcoma of the middle ear in a guinea pig (Cavia porcellus). 61
30104775 2018
13
An Immunohistochemical Study of Stathmin 1 Expression in Osteosarcoma Shows an Association with Metastases and Poor Patient Prognosis. 61
30169496 2018
14
Pulmonary Metastases from Chondroblastic Osteosarcoma. 61
29641960 2018
15
Metastatic Sternal Osteosarcoma: A Rare Tumor. 61
29682436 2018
16
Prosthetic rehabilitation involving the use of implants following a fibula free flap reconstruction in the treatment of Osteosarcoma of the maxilla: a case report. 61
29209690 2017
17
68Gallium-Arginine-Glycine-Aspartic Acid and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Chondroblastic Osteosarcoma of the Skull. 61
28878856 2017
18
Correlation between apparent diffusion coefficient and histopathology subtypes of osteosarcoma after neoadjuvant chemotherapy. 61
27852643 2017
19
Chondroblastic osteosarcoma mimicking periapical abscess. 61
28877285 2017
20
CD30 Expression in Pediatric Neoplasms, Study of 585 Cases. 61
28521633 2017
21
Chondroblastoma: An Update. 61
28557595 2017
22
cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma. 61
28552607 2017
23
Chondroblastic osteosarcoma arising in the maxilla mimicking the radiographic and histological characteristics of cemento-osseous lesions: A case report. 61
28529749 2017
24
Unique Image Characteristics of an Occipital Primary Chondroblastic Osteosarcoma: A Rare Case Report and a Brief Literature Review. 61
28413767 2017
25
Chondroblastic and fibroblastic osteosarcoma of the jaws: Report of two cases and review of literature. 61
28393823 2017
26
Chondroblastic osteosarcoma of the distal tibia: a rare case report. 61
28748013 2017
27
Establishment and characterization of a novel osteosarcoma cell line: CHOS. 61
27017908 2016
28
The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing sarcomas and chondrosarcomas. 61
27465835 2016
29
Chondroblastic osteosarcoma: Cytomorphologic characteristics and differential diagnosis on FNA. 61
26999748 2016
30
A chondroblastic osteosarcoma of the coronoid process mimicking a fragmented coronoid process in a dog. 61
27118393 2016
31
[Atipic osteosarcoma in the femoral shaft case report and review of the literature]. 61
27627776 2016
32
Management of Pelvic Chondroblastic Osteosarcoma after Urgent Spinal Decompression - A Report of 2 Cases. 61
27299134 2016
33
Chondroblastic osteosarcoma of breast in a case of phyllodes tumour with recurrence, a rare case report. 61
27639204 2016
34
Chondroblastic osteosarcoma secondary to fibrosarcoma: A case report and literature review. 61
26788171 2015
35
NELL-1 expression in tumors of cartilage. 61
27047227 2015
36
Polyostotic Chondroblastic Osteosarcoma in a Kestrel ( Falco tinnunculus ). 61
26771323 2015
37
[Increased sclerosis of the iliac fossa: not at first glance a chondroblastic osteosarcoma of the pelvis]. 61
25750114 2015
38
ERG expression in chondrogenic bone and soft tissue tumours. 61
25378537 2015
39
Outcomes of the treatment of head and neck sarcomas in a tertiary referral center. 61
26042220 2015
40
Extraskeletal chondroblastic osteosarcoma in the left atrium. 61
25205782 2014
41
Chondrosarcomas of the head and neck. 61
24213203 2014
42
Chondroblastic osteosarcoma. 61
25949008 2014
43
Diagnosis and treatment of low-grade osteosarcoma: experience with nine cases. 61
23881556 2014
44
Urinary bladder radiotherapy-related chondroblastic osteosarcoma: Rare case report and review of literature. 61
25125901 2014
45
Unusual case of chondroblastic osteosarcoma of the rib in an adult. 61
24887843 2014
46
Periosteal osteosarcoma arising from the rib and scapula: imaging features in two cases. 61
24843242 2014
47
Chondroblastic osteosarcoma of the left zygomatic bone: Rare case report and review of the literature. 61
25328313 2014
48
Research findings working with the p53 and Rb1 targeted osteosarcoma mouse model. 61
24959378 2014
49
Massive recurrent chondroblastic osteosarcoma of maxilla: a rare case report. 61
24596799 2014
50
Primary chondroblastic osteosarcoma of the breast. 61
26033758 2014

Variations for Chondroblastic Osteosarcoma

Expression for Chondroblastic Osteosarcoma

Search GEO for disease gene expression data for Chondroblastic Osteosarcoma.

Pathways for Chondroblastic Osteosarcoma

Pathways related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.64 TP53 IDH2 IDH1
2
Show member pathways
10.07 IDH2 IDH1

GO Terms for Chondroblastic Osteosarcoma

Cellular components related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.26 SERPINA3 MATN4 LGALS1 ACAN
2 extracellular region GO:0005576 9.23 SERPINA3 NELL1 MATN4 LGALS1 IDH1 FAM180A

Biological processes related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell aging GO:0007569 9.32 TP53 BGLAP
2 2-oxoglutarate metabolic process GO:0006103 9.26 IDH2 IDH1
3 NADP metabolic process GO:0006739 9.16 IDH2 IDH1
4 isocitrate metabolic process GO:0006102 8.96 IDH2 IDH1
5 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Chondroblastic Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
2 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Chondroblastic Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....