MCID: CHN004
MIFTS: 41

Chondroblastoma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Chondroblastoma

MalaCards integrated aliases for Chondroblastoma:

Name: Chondroblastoma 12 73 20 54 44 15 17 70
Chondroblastoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2649
MeSH 44 D002804
NCIt 50 C2945
SNOMED-CT 67 9001003
UMLS 70 C0008441

Summaries for Chondroblastoma

Disease Ontology : 12 A connective tissue benign neoplasm that derives from chondroblasts and begins in cartilage at the ends of long bones (thighbone, shinbone, humerus) close to the joints.

MalaCards based summary : Chondroblastoma, also known as chondroblastoma of bone, is related to aneurysmal bone cysts and benign giant cell tumor, and has symptoms including pain An important gene associated with Chondroblastoma is H3-3A (H3.3 Histone A), and among its related pathways/superpathways are ERK Signaling and Signaling by Wnt. The drug Denosumab has been mentioned in the context of this disorder. Affiliated tissues include bone, brain and thyroid, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or... more...

Related Diseases for Chondroblastoma

Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 aneurysmal bone cysts 31.0 USP6 TNFSF11
2 benign giant cell tumor 30.5 TNFSF11 SERPINA3 H3-3B H3-3A
3 chondromyxoid fibroma 30.3 SOX9 S100A2 PTHLH PTH1R FGFR3
4 chondrosarcoma 30.3 SOX9 SERPINA3 PTHLH FGFR3 ENO2
5 synovial chondromatosis 30.3 SOX9 FGFR3 FGFR1
6 malignant giant cell tumor 30.2 H3-3B H3-3A
7 osteochondroma 30.2 PTHLH FGFR3 FGFR1
8 bone giant cell tumor 30.1 USP6 TNFSF11 SERPINA3 H3-3B H3-3A
9 chondroblastic osteosarcoma 30.0 SERPINA3 H3-3B H3-3A
10 pigmented villonodular synovitis 30.0 TNFSF11 SERPINA3 PTHLH
11 telangiectatic osteogenic sarcoma 29.9 USP6 H3-3B H3-3A
12 meningothelial meningioma 29.6 SERPINA3 ENO2
13 gastrointestinal stromal tumor 29.5 PTGS2 FGFR3 ENO2 ANO1
14 bone inflammation disease 29.5 TNFSF11 SERPINA3 PTGS2 H2AC18
15 bone resorption disease 29.3 TNFSF11 SERPINA3 PTHLH PTH1R H2AC18
16 clear cell chondrosarcoma 28.9 SERPINA3 PTHLH H3C6 H3C3 H3-3B H3-3A
17 embryoma 11.0
18 osteogenic sarcoma 10.4
19 adult brain stem glioma 10.4 H3-3B H3-3A
20 rare tumor 10.4
21 fibroma 10.4
22 fgfr craniosynostosis syndromes 10.4 FGFR3 FGFR1
23 bone giant cell sarcoma 10.3 TNFSF11 H3-3B H3-3A
24 breast leiomyosarcoma 10.3 TNFSF11 ENO2
25 chondroma 10.3
26 spinal cord astrocytoma 10.3 H3-3B H3-3A
27 hemophilic arthropathy 10.3 TNFSF11 PTGS2
28 colon leiomyoma 10.3 H3-3B H3-3A ANO1
29 jejunal neoplasm 10.3 ENO2 ANO1
30 paratesticular lipoma 10.3 ENO2 ANO1
31 adult oligodendroglioma 10.3 H3-3B H3-3A FGFR1
32 lipoma of spermatic cord 10.3 ENO2 ANO1
33 childhood oligodendroglioma 10.3 H3-3B H3-3A FGFR1
34 gastric hemangioma 10.3 ENO2 ANO1
35 plagiocephaly 10.3 FGFR3 FGFR1
36 spinal cancer 10.3 H3-3B H3-3A ENO2
37 pacinian tumor 10.3 SLC2A1 ENO2
38 hypertelorism, microtia, facial clefting syndrome 10.3 TNFSF11 FGFR3 FGFR1
39 pulmonary artery leiomyosarcoma 10.3 ENO2 ANO1
40 syndromic craniosynostosis 10.3 FGFR3 FGFR1
41 malignant ovarian brenner tumor 10.3 TNFSF11 PTHLH
42 spinal cord oligodendroglioma 10.2 FGFR1 ENO2
43 thanatophoric dysplasia, type i 10.2 PTH1R FGFR3 FGFR1
44 congenital epulis 10.2 SERPINA3 ENO2
45 alpha thalassemia-x-linked intellectual disability syndrome 10.2 H3-3B H3-3A H2AC18
46 epulis 10.2 SERPINA3 ENO2
47 pediatric ovarian germ cell tumor 10.2 PTHLH ENO2
48 pediatric ovarian dysgerminoma 10.2 PTHLH ENO2
49 primary bone cancer 10.2
50 endobronchial leiomyoma 10.2 ENO2 ANO1

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to Chondroblastoma

Symptoms & Phenotypes for Chondroblastoma

UMLS symptoms related to Chondroblastoma:


pain

GenomeRNAi Phenotypes related to Chondroblastoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.77 FGFR1 FGFR3 HK2
2 Decreased viability GR00221-A-2 9.77 FGFR1 FGFR3 HK2
3 Decreased viability GR00221-A-3 9.77 FGFR3
4 Decreased viability GR00249-S 9.77 ANO1 FGFR3 H3-3B H3C6 HK2 SERPINA3
5 Decreased viability GR00381-A-1 9.77 CA10 USP6
6 Decreased viability GR00386-A-1 9.77 CA10 FGFR1 H3C3 H3C6 PTH1R SLC2A1
7 Decreased viability GR00402-S-2 9.77 ENO2 PTH1R SOX9 TNFSF11

MGI Mouse Phenotypes related to Chondroblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 ANO1 ENO2 FGFR1 FGFR3 H3-3B H3C3
2 growth/size/body region MP:0005378 9.77 ANO1 ENO2 FGFR1 FGFR3 H3-3B H3C3
3 respiratory system MP:0005388 9.23 ANO1 ENO2 FGFR3 PTGS2 PTH1R PTHLH

Drugs & Therapeutics for Chondroblastoma

Drugs for Chondroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 2 615258-40-7

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Chondroblastoma

Cochrane evidence based reviews: chondroblastoma

Genetic Tests for Chondroblastoma

Anatomical Context for Chondroblastoma

MalaCards organs/tissues related to Chondroblastoma:

40
Bone, Brain, Thyroid, Breast, Bone Marrow, Spinal Cord, Colon

Publications for Chondroblastoma

Articles related to Chondroblastoma:

(show top 50) (show all 961)
# Title Authors PMID Year
1
Clear cell chondrosarcoma: a pathological and immunohistochemical study. 61 54
10231420 1999
2
Surgical Strategy of Pediatric Benign Sacral Tumors. 61
33655901 2021
3
Functional treatment of temporal bone chondroblastoma: retrospective analysis of 3 cases. 61
32661717 2021
4
Percutaneous Radiofrequency Ablation of Appendicular Skeleton Chondroblastoma-an Experience from a Tertiary Care Cancer Center. 61
33612370 2021
5
Letter to the Editor Regarding "Temporal Bone Chondroblastoma: Systematic Review of Clinical Features and Outcomes". 61
33770842 2021
6
In Reply to the Letter to the Editor regarding "Temporal Bone Chondroblastoma: Systematic Review of Clinical Features and Outcomes". 61
33770843 2021
7
H3.3 K36M Mutation as a Clinical Diagnosis Method of Suspected Chondroblastoma Cases. 61
33620145 2021
8
[The H3.3 K36M mutation protein expression of H3.3 in chondroblastoma: a novel diagnostic biomarker]. 61
33677889 2021
9
Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis. 61
33727696 2021
10
The incorporation loci of H3.3K36M determine its preferential prevalence in chondroblastomas. 61
33762579 2021
11
Skull base chondroblastoma presenting as a deep lobe parotid tumour. 61
33637506 2021
12
Chondroblastoma: Is intralesional curettage with the use of adjuvants a sufficient way of therapy? 61
33364155 2021
13
Bone Tumours of the Talus: 18-Year Cohort of Patients With Rare Osteoid Lesions. 61
33791180 2021
14
What's New in Pediatric Orthopaedic Tumor Surgery. 61
33027233 2021
15
Preliminary proposal: a classification system for reconstruction with autologous femoral head after periacetabular tumors resection. 61
33557910 2021
16
H3F3A G34 mutation DNA sequencing and G34W immunohistochemistry analysis in 366 cases of giant cell tumors of bone and other bone tumors. 61
33021329 2021
17
Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital. 61
33181515 2021
18
Clear-cell chondrosarcomas: Fine-needle aspiration cytology, radiological findings, and patient demographics of a rare entity. 61
32786062 2021
19
Usefulness of β-catenin expression in the differential diagnosis of osteosarcoma, osteoblastoma, and chondroblastoma. 61
33511430 2021
20
Commentary on Letter to the Editor concerning "Management of cranial chondroblastoma in adults; a pooled analysis" by Amr Muhammed et al. 61
33092909 2021
21
Partial Articular Resurfacing Secondary to Pediatric Hip Chondroblastoma Curettage with a 5-YearFollow-Up: A Case Report. 61
33464000 2021
22
Missed radiographic and clinical findings in a case of non-idiopathic scoliosis resulting from chondroblastoma. 61
32827086 2021
23
Histone H3K27M Mutation in Brain Tumors. 61
33155136 2021
24
Histone Lysine-to-Methionine Mutation as Anticancer Drug Target. 61
33155140 2021
25
Letter to Editor Regarding "Clinicopathologic Analysis of Chondroblastoma in Adults: A Single-Institution Case Series" by Negri et al. 61
33435772 2021
26
Letter to the Editor concerning "Management of cranial chondroblastoma in adults; a pooled analysis" by Amr Muhammed et al. 61
33097286 2021
27
Metastasizing chondroblastoma: a rare bone tumor no longer supported by the WHO classification. 61
32594198 2021
28
Chondroblastoma's Lung Metastases Treated with Denosumab in Pediatric Patient. 61
32777878 2021
29
Analysis for clinical feature and outcome of chondroblastoma after surgical treatment: A single center experience of 92 cases. 61
33419623 2021
30
Primary sclerosing epithelioid fibrosarcoma of the spine: a single-institution experience. 61
33428796 2021
31
[Treatment of chondroblastoma of the humeral head : A tumour- and shoulder-orthopaedic challenge]. 61
32748105 2020
32
Chondroblastoma Expresses RANKL by RNA In Situ Hybridization and May Respond to Denosumab Therapy. 61
32826531 2020
33
Clinicopathologic characterization of malignant chondroblastoma: a neoplasm with locally aggressive behavior and metastatic potential that closely mimics chondroblastoma-like osteosarcoma. 61
32601382 2020
34
Solitary long-bone epiphyseal lesions in children: radiologic-pathological correlation and epidemiology. 61
32638051 2020
35
[Tumors affecting the temporomandibular joint - a literature review]. 61
33059872 2020
36
A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation. 61
33135541 2020
37
Clear cell chondrosarcoma of proximal femur: a rare entity with diagnostic dilemma. 61
33122229 2020
38
The epigenomics of sarcoma. 61
32782366 2020
39
Pediatric Chondroblastoma and the Need for Lung Staging at Presentation. 61
32658156 2020
40
A Destructive Tumor of the Proximal Tibia and Fibula: A Case Report Highlighting Challenging Diagnosis and Treatment of a Locally Advanced, Non-recurrent Chondroblastoma in 16 Years Old Patient. 61
33585319 2020
41
Temporal Bone Chondroblastoma: Systematic Review of Clinical Features and Outcomes. 61
32603862 2020
42
A Rare Case Report of Chondroblastoma Pisiform in Adolescent. 61
33489960 2020
43
Temporal Bone Chondroblastoma: a Rare Entity. 61
33041452 2020
44
Management of cranial chondroblastoma in adults; a pooled analysis. 61
32305254 2020
45
Chondroblastoma of the Navicular Bone: A Report of 2 Pediatric Cases. 61
32910575 2020
46
Clinicopathologic Analysis of Chondroblastoma in Adults: A Single-Institution Case Series. 61
32484057 2020
47
Chondroblastoma in the Sphenoid Sinus. 61
32603219 2020
48
Tenosynovial Giant Cell Tumor, Localized Type With Extensive Chondroid Metaplasia: A Case Report With Immunohistochemical and Molecular Genetic Analysis. 61
31771368 2020
49
Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases. 61
32036238 2020
50
Total Calcanectomy and Bilateral Iliac Bone Autograft Reconstruction for the Treatment of Calcaneal Chondroblastoma Involving a Secondary Aneurysmal Bone Cyst: A Case Report and Literature Review. 61
32354519 2020

Variations for Chondroblastoma

Expression for Chondroblastoma

Search GEO for disease gene expression data for Chondroblastoma.

Pathways for Chondroblastoma

Pathways related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 TNFSF11 SOX9 PTGS2 H3C6 H3C3 H3-3B
2
Show member pathways
12.67 SOX9 H3C6 H3C3 H3-3B H3-3A H2AC18
3
Show member pathways
12.56 H3C6 H3C3 H3-3B H3-3A H2AC18
4
Show member pathways
12.27 H3C6 H3C3 H3-3B H3-3A H2AC18
5 12.11 H3C6 H3C3 H3-3B H3-3A
6 12.11 HK2 H3C6 H3C3 H3-3B H3-3A
7 12.01 H3C6 H3C3 H3-3B H3-3A
8
Show member pathways
11.93 H3C6 H3C3 H3-3B H3-3A
9
Show member pathways
11.91 H3C6 H3C3 H3-3B H3-3A
10 11.76 SOX9 FGFR3 FGFR1
11 11.69 TNFSF11 PTHLH PTH1R FGFR1
12 11.68 PTGS2 FGFR3 FGFR1
13 11.52 H3C6 H3C3 H3-3B H3-3A
14 11.35 SOX9 SLC2A1 FGFR3 FGFR1
15 11.22 TNFSF11 PTHLH PTH1R
16 11.1 SLC2A1 HK2 FGFR3 FGFR1
17 10.83 SOX9 PTHLH PTH1R FGFR3 FGFR1
18 10.71 TNFSF11 PTH1R

GO Terms for Chondroblastoma

Cellular components related to Chondroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TNFSF11 SERPINA3 PTHLH H3C6 H3C3 H3-3B
2 extracellular exosome GO:0070062 9.97 SLC2A1 SERPINA3 H3C6 H3C3 H3-3B H3-3A
3 chromosome GO:0005694 9.8 H3C6 H3C3 H3-3B H3-3A H2AC18
4 protein-containing complex GO:0032991 9.73 SOX9 PTGS2 H3C6 H3C3 H3-3B H3-3A
5 nuclear chromosome GO:0000228 9.26 H3C6 H3C3 H3-3B H3-3A
6 Barr body GO:0001740 9.16 H3-3B H3-3A
7 nucleosome GO:0000786 9.02 H3C6 H3C3 H3-3B H3-3A H2AC18

Biological processes related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.99 SOX9 PTHLH PTH1R PTGS2 FGFR3 FGFR1
2 cellular protein metabolic process GO:0044267 9.88 H3C6 H3C3 H3-3B H3-3A
3 blood coagulation GO:0007596 9.86 H3C6 H3C3 H3-3B H3-3A
4 cellular response to mechanical stimulus GO:0071260 9.76 SOX9 SLC2A1 PTGS2
5 regulation of gene silencing by miRNA GO:0060964 9.73 H3C6 H3C3 H3-3B H3-3A
6 chondrocyte differentiation GO:0002062 9.72 SOX9 PTH1R FGFR3
7 skeletal system development GO:0001501 9.72 SOX9 PTHLH PTH1R FGFR3 FGFR1
8 regulation of megakaryocyte differentiation GO:0045652 9.71 H3C6 H3C3 H3-3B H3-3A
9 embryo implantation GO:0007566 9.7 PTGS2 H3-3B H3-3A
10 negative regulation of gene expression, epigenetic GO:0045814 9.67 H3C6 H3C3 H3-3B H3-3A
11 regulation of gene silencing GO:0060968 9.59 H3C6 H3C3
12 positive regulation of phospholipase activity GO:0010518 9.57 FGFR3 FGFR1
13 bone mineralization GO:0030282 9.56 PTHLH PTH1R PTGS2 FGFR3
14 nucleosome assembly GO:0006334 9.55 SOX9 H3C6 H3C3 H3-3B H3-3A
15 pericentric heterochromatin assembly GO:0031508 9.54 H3-3B H3-3A
16 regulation of centromere complex assembly GO:0090230 9.49 H3-3B H3-3A
17 negative regulation of chromosome condensation GO:1902340 9.48 H3-3B H3-3A
18 telomeric heterochromatin assembly GO:0031509 9.46 H3-3B H3-3A
19 chromatin silencing at rDNA GO:0000183 9.26 H3C6 H3C3 H3-3B H3-3A
20 telomere organization GO:0032200 8.92 H3C6 H3C3 H3-3B H3-3A

Molecular functions related to Chondroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 USP6 TNFSF11 SOX9 SLC2A1 SERPINA3 S100A2
2 protein heterodimerization activity GO:0046982 9.02 H3C6 H3C3 H3-3B H3-3A H2AC18
3 fibroblast growth factor-activated receptor activity GO:0005007 8.96 FGFR3 FGFR1

Sources for Chondroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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