MCID: CHN004
MIFTS: 40

Chondroblastoma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Chondroblastoma

MalaCards integrated aliases for Chondroblastoma:

Name: Chondroblastoma 12 76 53 55 44 15 73
Chondroblastoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2649
MeSH 44 D002804
NCIt 50 C2945
SNOMED-CT 68 9001003
UMLS 73 C0008441

Summaries for Chondroblastoma

MalaCards based summary : Chondroblastoma, also known as chondroblastoma of bone, is related to chondromyxoid fibroma and clear cell chondrosarcoma, and has symptoms including pain An important gene associated with Chondroblastoma is H3F3A (H3 Histone Family Member 3A), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Denosumab and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and cortex, and related phenotypes are growth/size/body region and mortality/aging

Wikipedia : 76 Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or... more...

Related Diseases for Chondroblastoma

Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 chondromyxoid fibroma 30.4 PTH1R PTHLH SOX9
2 clear cell chondrosarcoma 30.4 H3F3A PTH1R PTHLH
3 bone giant cell tumor 30.3 H3F3A TNFSF11
4 embryoma 11.1
5 chondrosarcoma 10.3
6 giant cell tumor 10.3
7 bone giant cell sarcoma 10.2 H3F3A H3F3B
8 malignant giant cell tumor 10.2 H3F3A H3F3B
9 brain stem cancer 10.2 H3F3A H3F3B
10 adult astrocytic tumour 10.2 H3F3A H3F3B
11 spinal cord astrocytoma 10.2 H3F3A H3F3B
12 diffuse intrinsic pontine glioma 10.2 H3F3A H3F3B
13 chondroma 10.1
14 degos 'en cocarde' erythrokeratoderma 10.1
15 brain stem glioma 10.1 H3F3A H3F3B
16 juxtacortical chondroma 10.1 PTH1R PTHLH
17 tooth resorption 10.1 PTH1R TNFSF11
18 hypercalcemia, infantile, 1 10.1 PTH1R PTHLH
19 multicentric carpotarsal osteolysis syndrome 10.0 PTHLH TNFSF11
20 metaphyseal chondrodysplasia, jansen type 10.0 PTH1R PTHLH
21 achondroplasia 10.0 PTH1R SOX9
22 enchondromatosis, multiple, ollier type 10.0 PTH1R PTHLH
23 supratentorial cancer 10.0 H3F3A H3F3B
24 osteogenic sarcoma 10.0
25 synovitis 10.0
26 histiocytoma 10.0
27 fibrous histiocytoma 10.0
28 enchondroma 10.0
29 pseudohypoparathyroidism, type ib 10.0 PTH1R PTHLH
30 pseudohypoparathyroidism 10.0 PTH1R PTHLH
31 osteochondrodysplasia 10.0 PTH1R PTHLH SOX9
32 cerebrum cancer 9.9 H3F3A H3F3B
33 hemophilic arthropathy 9.9 PTGS2 TNFSF11
34 tooth ankylosis 9.9 PTH1R PTHLH TNFSF11
35 bone disease 9.9 PTH1R PTHLH TNFSF11
36 brachydactyly, type e1 9.9 PTGS2 PTHLH
37 nevus, epidermal 9.9
38 osteoid osteoma 9.9
39 aneurysmal bone cysts 9.9
40 arthritis 9.9
41 fibrous dysplasia 9.9
42 sarcoma 9.9
43 cauda equina syndrome 9.9
44 pneumothorax 9.9
45 malignant fibroxanthoma 9.9
46 pigmented villonodular synovitis 9.9
47 papillary carcinoma 9.9
48 mesenchymal chondrosarcoma 9.9
49 meningothelial meningioma 9.9
50 villonodular synovitis 9.9

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to Chondroblastoma

Symptoms & Phenotypes for Chondroblastoma

UMLS symptoms related to Chondroblastoma:


pain

MGI Mouse Phenotypes related to Chondroblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.92 H3F3B HK2 PTGS2 PTH1R PTHLH SLC2A1
2 mortality/aging MP:0010768 9.86 H3F3B HK2 PTGS2 PTH1R PTHLH SLC2A1
3 embryo MP:0005380 9.85 H3F3B HK2 PTGS2 PTH1R SLC2A1 SOX9
4 neoplasm MP:0002006 9.55 HK2 PTGS2 PTH1R PTHLH TNFSF11
5 normal MP:0002873 9.43 H3F3B HK2 PTGS2 PTHLH SOX9 TNFSF11
6 respiratory system MP:0005388 9.02 PTGS2 PTH1R PTHLH SOX9 TNFSF11

Drugs & Therapeutics for Chondroblastoma

Drugs for Chondroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 2 615258-40-7
2 Bone Density Conservation Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Chondroblastoma

Cochrane evidence based reviews: chondroblastoma

Genetic Tests for Chondroblastoma

Anatomical Context for Chondroblastoma

MalaCards organs/tissues related to Chondroblastoma:

41
Bone, Lung, Cortex, Brain, Spinal Cord, Tonsil, Prostate

Publications for Chondroblastoma

Articles related to Chondroblastoma:

(show top 50) (show all 444)
# Title Authors Year
1
The effects of surgical treatment with chondroblastoma in children and adolescents in open epiphyseal plate of long bones. ( 29361956 )
2018
2
Chondroblastoma of the distal femoral metaphysis: A case report with emphasis on imaging findings and differential diagnosis. ( 29702979 )
2018
3
Aggressive curettage of a chondroblastoma-like osteosarcoma of the proximal end of the tibia. A case report with seven-year follow-up. ( 29307095 )
2018
4
Clinical features, treatments and long-term follow-up outcomes of spinal chondroblastoma: report of 13 clinical cases in a single center. ( 29968040 )
2018
5
Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis. ( 29774790 )
2018
6
"Chondroblastoma-like" epithelioid fibrous histiocytoma: A previously undescribed and potentially confusing variant. ( 29068085 )
2018
7
Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy. ( 29757500 )
2018
8
Combined Autograft and Bone Cement for Painful Chondroblastoma: A Case Report. ( 29307744 )
2018
9
Chondroblastoma-like tumor of the skull in a patient with cardio-facio-cutaneous syndrome. ( 30100356 )
2018
10
Chondroblastoma of frontal bone: A tumor in an unusual location in a young child. ( 30178739 )
2018
11
Chondroblastoma: An evaluation of the recurrences and functional outcomes following treatment. ( 30249436 )
2018
12
Percutaneous Cryotherapy for Treatment of Chondroblastoma: Early Experience. ( 30327928 )
2018
13
Chondroblastoma of the Foot: 40 Cases From a Single Institution. ( 30368424 )
2018
14
Three dimensional surgical planning for mosaicplasty in chondroblastoma of femoral head with articular disruption. ( 30391136 )
2018
15
Functional and Oncological Outcome After Treatment of Chondroblastoma With Intralesional Curettage. ( 30418383 )
2018
16
The diagnosis and treatment of tibial intercondylar chondroblastoma. ( 30517285 )
2018
17
Spontaneous Conventional Osteosarcoma Transformation of a Chondroblastoma: A Case Report and Literature Review. ( 30532312 )
2018
18
Spontaneous Conventional Osteosarcoma Transformation of a Chondroblastoma: A Case Report and Literature Review. ( 29416176 )
2018
19
Histone H3K36M mutation and trimethylation patterns in chondroblastoma. ( 30098026 )
2018
20
Use of denosumab in recurrent chondroblastoma of the squamous temporal bone: a case report. ( 28396758 )
2017
21
Chondroblastoma in adult age. ( 28634924 )
2017
22
A Rare Case of Chondroblastoma with Revision After Graft Rejection<sub>A Case Report</sub>. ( 29077506 )
2017
23
Lateral skull base chondroblastoma resected with facial nerve posterior transposition. ( 28502566 )
2017
24
Unusual presentation of chondroblastoma mimicking Trevor's disease. ( 28862242 )
2017
25
Intra-axial chondroblastoma: A bony tumor in the cerebral hemisphere - A case report and review of literature. ( 28484548 )
2017
26
A rare probable chondroblastoma of the calcaneus in a pre-Columbian subadult from Illinois. ( 28290305 )
2017
27
Unusual presentation of chondroblastoma mimicking Trevor's disease. ( 28272066 )
2017
28
Chondroblastoma of the rib in a 47-year-old man: a case report with a systematic review of literature. ( 29268433 )
2017
29
Chondroblastoma of extra-craniofacial bones: Clinicopathological analyses of 103 cases. ( 28971570 )
2017
30
Chondroblastoma: An Update. ( 28557595 )
2017
31
An unusual localization of chondroblastoma: The triradiate cartilage; from a case report a reconstructive technique proposal with imaging evolution. ( 28878541 )
2017
32
Intraoperative crush smear cytology of vertebral chondroblastoma: A diagnostic challenge. ( 28834661 )
2017
33
Capitate Chondroblastoma: A Case Report and Review of the Literature. ( 28344536 )
2017
34
Massive Chondroblastoma of the Talus: Treatment With En Bloc Talectomy and Tibiocalcaneal Arthrodesis: Long-Term Follow-up of a Case. ( 27798068 )
2017
35
Temporal bone chondroblastoma: Imaging characteristics with pathologic correlation. ( 28736834 )
2017
36
Proximal Tibia Chondroblastoma Treated With Curettage and Bone Graft and Cement Use. ( 26726978 )
2016
37
Chondroblastoma of sella and anterior cranial fossa base. ( 26394622 )
2016
38
Operative treatment of chondroblastoma: a study of 11 cases. ( 26984656 )
2016
39
A rare case of chondroblastoma of the acromion. ( 27956080 )
2016
40
Chondroblastoma of the thoracic spine: a rare location. Case report with radiologic-pathologic correlation. ( 27966029 )
2016
41
The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. ( 26844533 )
2016
42
Chondroblastoma of the Medial Malleolus: A Case Report of A Rare Tumor at an Extremely Uncommon Site. ( 27299121 )
2016
43
Epigenetics: Histone mutations reprogramme chondroblastoma. ( 27339705 )
2016
44
Temporal bone chondroblastoma totally invisible on MRI. ( 26743837 )
2016
45
Malignant chondroblastoma of extraskeletal origin. ( 27127749 )
2016
46
Complete local tumor control after curettage of chondroblastoma-a retrospective analysis. ( 27067177 )
2016
47
Aneurysmal Bone Cyst: An Uncommon Secondary Event in Calcaneal Chondroblastoma. ( 27504302 )
2016
48
What Happens to the Articular Surface After Curettage for Epiphyseal Chondroblastoma? A Report on Functional Results, Arthritis, and Arthroplasty. ( 26831477 )
2016
49
Fine needle aspiration cytology of chondroblastoma: A report of two cases with brief review of pitfalls. ( 27011442 )
2016
50
Reconstruction with double pedicel fibular graft and ankle arthrodesis for aggressive chondroblastoma in the distal tibia. ( 27176605 )
2016

Variations for Chondroblastoma

Expression for Chondroblastoma

Search GEO for disease gene expression data for Chondroblastoma.

Pathways for Chondroblastoma

GO Terms for Chondroblastoma

Cellular components related to Chondroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome GO:0000228 9.26 H3F3A H3F3B
2 protein-containing complex GO:0032991 9.26 H3F3A H3F3B PTGS2 SOX9
3 nuclear nucleosome GO:0000788 9.16 H3F3A H3F3B
4 Barr body GO:0001740 8.62 H3F3A H3F3B

Biological processes related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.87 PTGS2 PTH1R PTHLH SOX9
2 negative regulation of cell proliferation GO:0008285 9.8 PTGS2 PTH1R PTHLH SOX9
3 brain development GO:0007420 9.79 CA10 H3F3A H3F3B
4 skeletal system development GO:0001501 9.71 PTH1R PTHLH SOX9
5 nucleosome assembly GO:0006334 9.65 H3F3A H3F3B SOX9
6 regulation of gene silencing by miRNA GO:0060964 9.63 H3F3A H3F3B
7 negative regulation of gene expression, epigenetic GO:0045814 9.63 H3F3A H3F3B
8 male gonad development GO:0008584 9.63 H3F3A H3F3B SOX9
9 chondrocyte differentiation GO:0002062 9.62 PTH1R SOX9
10 chromatin silencing at rDNA GO:0000183 9.61 H3F3A H3F3B
11 oogenesis GO:0048477 9.61 H3F3A H3F3B
12 ossification GO:0001503 9.61 PTH1R SOX9 TNFSF11
13 nucleus organization GO:0006997 9.6 H3F3A H3F3B
14 ERK1 and ERK2 cascade GO:0070371 9.59 SOX9 TNFSF11
15 telomere organization GO:0032200 9.58 H3F3A H3F3B
16 DNA replication-independent nucleosome assembly GO:0006336 9.58 H3F3A H3F3B
17 cellular response to mechanical stimulus GO:0071260 9.58 PTGS2 SLC2A1 SOX9
18 bone resorption GO:0045453 9.56 PTH1R TNFSF11
19 osteoblast development GO:0002076 9.55 PTH1R PTHLH
20 negative regulation of chondrocyte differentiation GO:0032331 9.52 PTHLH SOX9
21 muscle cell differentiation GO:0042692 9.51 H3F3A H3F3B
22 embryo implantation GO:0007566 9.43 H3F3A H3F3B PTGS2
23 pericentric heterochromatin assembly GO:0031508 9.37 H3F3A H3F3B
24 bone mineralization GO:0030282 9.33 PTGS2 PTH1R PTHLH
25 regulation of centromere complex assembly GO:0090230 9.32 H3F3A H3F3B
26 negative regulation of chromosome condensation GO:1902340 8.96 H3F3A H3F3B
27 telomeric heterochromatin assembly GO:0031509 8.62 H3F3A H3F3B

Molecular functions related to Chondroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 9.16 PTH1R SLC2A1
2 nucleosomal DNA binding GO:0031492 8.96 H3F3A H3F3B
3 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3F3A H3F3B

Sources for Chondroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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