MCID: CHN004
MIFTS: 42

Chondroblastoma

Categories: Rare diseases, Cancer diseases, Bone diseases

Aliases & Classifications for Chondroblastoma

MalaCards integrated aliases for Chondroblastoma:

Name: Chondroblastoma 12 76 53 55 44 15 73
Chondroblastoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2649
MeSH 44 D002804
NCIt 50 C2945
UMLS 73 C0008441

Summaries for Chondroblastoma

MalaCards based summary : Chondroblastoma, also known as chondroblastoma of bone, is related to clear cell chondrosarcoma and chondromyxoid fibroma, and has symptoms including pain An important gene associated with Chondroblastoma is H3F3A (H3 Histone Family Member 3A), and among its related pathways/superpathways are Neural Crest Differentiation and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone, lung and testes, and related phenotypes are growth/size/body region and mortality/aging

Wikipedia : 76 Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or... more...

Related Diseases for Chondroblastoma

Diseases related to Chondroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 clear cell chondrosarcoma 30.1 H3F3A PTH1R PTHLH
2 chondromyxoid fibroma 29.2 FGFR3 PTH1R PTHLH SOX9
3 osteochondroma 28.2 FGFR1 FGFR3 PTHLH
4 embryoma 11.0
5 bone giant cell sarcoma 10.7 H3F3A H3F3B
6 malignant giant cell tumor 10.6 H3F3A H3F3B
7 brain stem cancer 10.6 H3F3A H3F3B
8 adult astrocytic tumour 10.6 H3F3A H3F3B
9 diffuse intrinsic pontine glioma 10.5 H3F3A H3F3B
10 spinal cord astrocytoma 10.5 H3F3A H3F3B
11 aneurysm 10.4
12 aneurysmal bone cysts 10.4
13 tooth resorption 10.3 PTH1R TNFSF11
14 juxtacortical chondroma 10.3 PTH1R PTHLH
15 hypercalcemia, infantile, 1 10.3 PTH1R PTHLH
16 pyle disease 10.2 PTH1R PTHLH
17 multicentric carpotarsal osteolysis syndrome 10.2 PTHLH TNFSF11
18 chondrosarcoma 10.2
19 pseudohypoparathyroidism, type ib 10.1 PTH1R PTHLH
20 jaw cancer 10.1 PTHLH TNFSF11
21 giant cell tumor 10.1
22 enchondromatosis, multiple, ollier type 10.1 PTH1R PTHLH
23 keratocystic odontogenic tumor 10.0 PTHLH TNFSF11
24 chorioangioma 10.0 FGFR3 PTHLH
25 chondroma 9.9
26 bone giant cell tumor 9.9
27 hemangioma of intra-abdominal structure 9.9 FGFR3 PTHLH
28 pseudohypoparathyroidism 9.9 PTH1R PTHLH
29 aging 9.9
30 cervicitis 9.9
31 synovitis 9.9
32 histiocytoma 9.9
33 fibrous histiocytoma 9.9
34 periostitis 9.9
35 cherubism 9.8 FGFR3 TNFSF11
36 tooth ankylosis 9.8 PTH1R PTHLH TNFSF11
37 brain stem glioma 9.7 FGFR1 H3F3A H3F3B
38 nevus, epidermal 9.7
39 osteoid osteoma 9.7
40 arthritis 9.7
41 fibrous dysplasia 9.7
42 sarcoma 9.7
43 cauda equina syndrome 9.7
44 pneumothorax 9.7
45 malignant fibroxanthoma 9.7
46 pigmented villonodular synovitis 9.7
47 papillary carcinoma 9.7
48 conventional central osteosarcoma 9.7
49 cerebritis 9.7
50 mesenchymal chondrosarcoma 9.7

Graphical network of the top 20 diseases related to Chondroblastoma:



Diseases related to Chondroblastoma

Symptoms & Phenotypes for Chondroblastoma

UMLS symptoms related to Chondroblastoma:


pain

MGI Mouse Phenotypes related to Chondroblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.03 SOX9 H3F3B HK2 PTH1R FGFR1 PTHLH
2 mortality/aging MP:0010768 9.97 SOX9 H3F3B HK2 PTH1R FGFR1 PTHLH
3 craniofacial MP:0005382 9.95 TNFSF11 PTH1R FGFR1 PTHLH FGFR3 SOX9
4 limbs/digits/tail MP:0005371 9.88 TNFSF11 PTH1R FGFR1 PTHLH FGFR3 SOX9
5 digestive/alimentary MP:0005381 9.85 FGFR3 SOX9 PTH1R FGFR1 PTHLH
6 normal MP:0002873 9.8 SOX9 H3F3B HK2 FGFR1 FGFR3 TNFSF11
7 reproductive system MP:0005389 9.73 SOX9 H3F3B FGFR1 PTHLH FGFR3 TNFSF11
8 respiratory system MP:0005388 9.55 FGFR3 SOX9 PTH1R PTHLH TNFSF11
9 skeleton MP:0005390 9.43 FGFR3 SOX9 PTH1R FGFR1 PTHLH TNFSF11
10 vision/eye MP:0005391 9.1 SOX9 TNFSF11 PTH1R FGFR1 PTHLH FGFR3

Drugs & Therapeutics for Chondroblastoma

Search Clinical Trials , NIH Clinical Center for Chondroblastoma

Cochrane evidence based reviews: chondroblastoma

Genetic Tests for Chondroblastoma

Anatomical Context for Chondroblastoma

MalaCards organs/tissues related to Chondroblastoma:

41
Bone, Lung, Testes, Thyroid, Cortex

Publications for Chondroblastoma

Articles related to Chondroblastoma:

(show top 50) (show all 422)
# Title Authors Year
1
The effects of surgical treatment with chondroblastoma in children and adolescents in open epiphyseal plate of long bones. ( 29361956 )
2018
2
Chondroblastoma of the distal femoral metaphysis: A case report with emphasis on imaging findings and differential diagnosis. ( 29702979 )
2018
3
Aggressive curettage of a chondroblastoma-like osteosarcoma of the proximal end of the tibia. A case report with seven-year follow-up. ( 29307095 )
2018
4
Clinical features, treatments and long-term follow-up outcomes of spinal chondroblastoma: report of 13 clinical cases in a single center. ( 29968040 )
2018
5
Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis. ( 29774790 )
2018
6
"Chondroblastoma-like" epithelioid fibrous histiocytoma: A previously undescribed and potentially confusing variant. ( 29068085 )
2018
7
Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy. ( 29757500 )
2018
8
Combined Autograft and Bone Cement for Painful Chondroblastoma: A Case Report. ( 29307744 )
2018
9
Spontaneous Conventional Osteosarcoma Transformation of a Chondroblastoma: A Case Report and Literature Review. ( 29416176 )
2018
10
Use of denosumab in recurrent chondroblastoma of the squamous temporal bone: a case report. ( 28396758 )
2017
11
Chondroblastoma in adult age. ( 28634924 )
2017
12
A Rare Case of Chondroblastoma with Revision After Graft Rejection<sub>A Case Report</sub>. ( 29077506 )
2017
13
Lateral skull base chondroblastoma resected with facial nerve posterior transposition. ( 28502566 )
2017
14
Unusual presentation of chondroblastoma mimicking Trevor's disease. ( 28862242 )
2017
15
Intra-axial chondroblastoma: A bony tumor in the cerebral hemisphere - A case report and review of literature. ( 28484548 )
2017
16
H3F3 mutation status of giant cell tumors of the bone, chondroblastomas and their mimics: a combined high resolution melting and pyrosequencing approach. ( 28059095 )
2017
17
A rare probable chondroblastoma of the calcaneus in a pre-Columbian subadult from Illinois. ( 28290305 )
2017
18
Unusual presentation of chondroblastoma mimicking Trevor's disease. ( 28272066 )
2017
19
Chondroblastoma of the rib in a 47-year-old man: a case report with a systematic review of literature. ( 29268433 )
2017
20
Chondroblastoma of extra-craniofacial bones: Clinicopathological analyses of 103 cases. ( 28971570 )
2017
21
Chondroblastoma: An Update. ( 28557595 )
2017
22
An unusual localization of chondroblastoma: The triradiate cartilage; from a case report a reconstructive technique proposal with imaging evolution. ( 28878541 )
2017
23
Intraoperative crush smear cytology of vertebral chondroblastoma: A diagnostic challenge. ( 28834661 )
2017
24
Capitate Chondroblastoma: A Case Report and Review of the Literature. ( 28344536 )
2017
25
Temporal bone chondroblastoma: Imaging characteristics with pathologic correlation. ( 28736834 )
2017
26
Proximal Tibia Chondroblastoma Treated With Curettage and Bone Graft and Cement Use. ( 26726978 )
2016
27
Chondroblastoma of sella and anterior cranial fossa base. ( 26394622 )
2016
28
Operative treatment of chondroblastoma: a study of 11 cases. ( 26984656 )
2016
29
A rare case of chondroblastoma of the acromion. ( 27956080 )
2016
30
Chondroblastoma of the thoracic spine: a rare location. Case report with radiologic-pathologic correlation. ( 27966029 )
2016
31
The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. ( 26844533 )
2016
32
Chondroblastoma of the Medial Malleolus: A Case Report of A Rare Tumor at an Extremely Uncommon Site. ( 27299121 )
2016
33
Epigenetics: Histone mutations reprogramme chondroblastoma. ( 27339705 )
2016
34
Temporal bone chondroblastoma totally invisible on MRI. ( 26743837 )
2016
35
Malignant chondroblastoma of extraskeletal origin. ( 27127749 )
2016
36
Complete local tumor control after curettage of chondroblastoma-a retrospective analysis. ( 27067177 )
2016
37
Aneurysmal Bone Cyst: An Uncommon Secondary Event in Calcaneal Chondroblastoma. ( 27504302 )
2016
38
What Happens to the Articular Surface After Curettage for Epiphyseal Chondroblastoma? A Report on Functional Results, Arthritis, and Arthroplasty. ( 26831477 )
2016
39
Reconstruction with double pedicel fibular graft and ankle arthrodesis for aggressive chondroblastoma in the distal tibia. ( 27176605 )
2016
40
Massive Chondroblastoma of the Talus: Treatment With En Bloc Talectomy and Tibiocalcaneal Arthrodesis: Long-Term Follow-up of a Case. ( 27798068 )
2016
41
Fine needle aspiration cytology of chondroblastoma: A report of two cases with brief review of pitfalls. ( 27011442 )
2016
42
Chondroblastoma of bone in the extremities: a multicenter retrospective study. ( 26041854 )
2015
43
Arthroscopic burring of exposed cement following curettage and cavity filling cementation for chondroblastoma of the proximal tibia. ( 25750896 )
2015
44
Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases. ( 27408892 )
2015
45
Temporal Bone Localized Chondroblastoma. ( 26517458 )
2015
46
Radiofrequency ablation of chondroblastoma: long-term clinical and imaging outcomes. ( 25432292 )
2015
47
Chondroblastoma-like osteosarcoma: a case report and review. ( 25492634 )
2015
48
Chondroblastoma of the scaphoid: A case report. ( 26458718 )
2015
49
Chondroblastoma of the Clivus: Case Report and Review. ( 26623238 )
2015
50
Chondroblastoma of the temporomandibular joint lateral capsule: a case report. ( 26714409 )
2015

Variations for Chondroblastoma

Expression for Chondroblastoma

Search GEO for disease gene expression data for Chondroblastoma.

Pathways for Chondroblastoma

GO Terms for Chondroblastoma

Cellular components related to Chondroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 FGFR1 FGFR3 H3F3A H3F3B PTHLH TNFSF11
2 nuclear nucleosome GO:0000788 9.16 H3F3A H3F3B
3 receptor complex GO:0043235 9.13 FGFR1 FGFR3 PTH1R
4 Barr body GO:0001740 8.62 H3F3A H3F3B

Biological processes related to Chondroblastoma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 FGFR1 FGFR3 PTH1R PTHLH SOX9
2 positive regulation of protein kinase B signaling GO:0051897 9.73 FGFR1 FGFR3 TNFSF11
3 nucleosome assembly GO:0006334 9.69 H3F3A H3F3B SOX9
4 male gonad development GO:0008584 9.67 H3F3A H3F3B SOX9
5 ossification GO:0001503 9.65 PTH1R SOX9 TNFSF11
6 regulation of cell differentiation GO:0045595 9.63 FGFR1 SOX9
7 embryo implantation GO:0007566 9.63 H3F3A H3F3B
8 chromatin silencing at rDNA GO:0000183 9.62 H3F3A H3F3B
9 cell maturation GO:0048469 9.62 FGFR1 PTH1R
10 oogenesis GO:0048477 9.61 H3F3A H3F3B
11 ERK1 and ERK2 cascade GO:0070371 9.61 SOX9 TNFSF11
12 telomere organization GO:0032200 9.6 H3F3A H3F3B
13 nucleus organization GO:0006997 9.59 H3F3A H3F3B
14 positive regulation of mesenchymal cell proliferation GO:0002053 9.58 FGFR1 SOX9
15 DNA replication-independent nucleosome assembly GO:0006336 9.58 H3F3A H3F3B
16 bone resorption GO:0045453 9.57 PTH1R TNFSF11
17 osteoblast development GO:0002076 9.55 PTH1R PTHLH
18 negative regulation of chondrocyte differentiation GO:0032331 9.54 PTHLH SOX9
19 muscle cell differentiation GO:0042692 9.52 H3F3A H3F3B
20 bone mineralization GO:0030282 9.5 FGFR3 PTH1R PTHLH
21 positive regulation of phospholipase activity GO:0010518 9.46 FGFR1 FGFR3
22 pericentric heterochromatin assembly GO:0031508 9.43 H3F3A H3F3B
23 regulation of centromere complex assembly GO:0090230 9.37 H3F3A H3F3B
24 skeletal system development GO:0001501 9.35 FGFR1 FGFR3 PTH1R PTHLH SOX9
25 telomeric heterochromatin assembly GO:0031509 9.26 H3F3A H3F3B
26 negative regulation of chromosome condensation GO:1902340 9.16 H3F3A H3F3B
27 chondrocyte differentiation GO:0002062 8.92 FGFR1 FGFR3 PTH1R SOX9

Molecular functions related to Chondroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 9.32 H3F3A H3F3B
2 1-phosphatidylinositol-3-kinase activity GO:0016303 9.26 FGFR1 FGFR3
3 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.16 H3F3A H3F3B
4 fibroblast growth factor binding GO:0017134 8.96 FGFR1 FGFR3
5 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR1 FGFR3

Sources for Chondroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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