MCID: CHN059
MIFTS: 51

Chondrocalcinosis

Categories: Bone diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Chondrocalcinosis

MalaCards integrated aliases for Chondrocalcinosis:

Name: Chondrocalcinosis 12 73 29 54 6 15
Pseudogout 12 73 54 70
Calcium Pyrophosphate Deposition Disease 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1156
ICD9CM 34 712.1
NCIt 50 C34955
SNOMED-CT 67 201624004 201625003
UMLS 70 C0033802 C0157852 C0553730

Summaries for Chondrocalcinosis

Disease Ontology : 12 An arthritis that has material basis in the accumulation of salt crystals located in joint.

MalaCards based summary : Chondrocalcinosis, also known as pseudogout, is related to chondrocalcinosis 2 and familial calcium pyrophosphate deposition, and has symptoms including joint stiffness An important gene associated with Chondrocalcinosis is CCAL1 (Chondrocalcinosis 1 (Calcium Pyrophosphate-Deposition Disease, Early Onset Osteoarthritis)), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs Povidone and Colchicine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and kidney, and related phenotypes are growth/size/body region and hematopoietic system

Wikipedia : 73 Chondrocalcinosis or cartilage calcification is calcification (accumulation of calcium salts) in hyaline... more...

Related Diseases for Chondrocalcinosis

Diseases in the Chondrocalcinosis family:

Chondrocalcinosis 2 Chondrocalcinosis Due to Apatite Crystal Deposition
Chondrocalcinosis 1

Diseases related to Chondrocalcinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
# Related Disease Score Top Affiliating Genes
1 chondrocalcinosis 2 33.2 OTULIN LOC100130744 ANKH
2 familial calcium pyrophosphate deposition 32.0 TNFRSF11B OTULIN LOC100130744 ANKH
3 hypocalciuric hypercalcemia, familial, type i 31.9 GNA11 CASR AP2S1
4 hypocalciuric hypercalcemia, familial, type ii 31.9 GNA11 CASR AP2S1
5 gitelman syndrome 31.8 SLC12A3 REN CASR
6 familial hypocalciuric hypercalcemia 31.7 GNA11 CASR AP2S1
7 hypocalciuric hypercalcemia, familial, type iii 31.6 GNA11 CASR AP2S1
8 hypophosphatasia 30.7 ENPP1 ANKH ALPL
9 ankylosis 30.5 TNFRSF11B ENPP1 ANKH
10 hypokalemia 30.4 SLC12A3 REN CASR
11 hyperostosis 30.4 TNFRSF11B ANKH ALPL
12 enthesopathy 30.3 MEFV ENPP1 ANKH
13 hypophosphatasia, adult 30.3 ENPP1 ANKH ALPL
14 paget's disease of bone 30.3 TNFRSF11B CASR ALPL
15 tendinopathy 30.2 MMP3 MMP1 ENPP1
16 spondyloarthropathy 1 30.1 TNFRSF11B MMP3 ANKH
17 osteoarthritis 30.0 TNFRSF11B MMP3 MMP1 IL1B
18 gout 30.0 NLRP3 MEFV IL1B
19 osteomalacia 29.9 ENPP1 CASR ALPL
20 periarthritis 29.9 MEFV ENPP1 ANKH ALPL
21 bartter syndrome, type 3 29.8 SLC12A3 REN CASR
22 synovitis 29.8 TNFRSF11B MMP3 MMP1 IL1B
23 bursitis 29.6 MMP3 IL1B ALPL
24 uremia 29.6 TNFRSF11B REN ENPP1 CASR
25 prosthetic joint infection 29.6 TNFRSF11B IL1B
26 craniometaphyseal dysplasia, autosomal dominant 29.5 TNFRSF11B OTULIN LOC100130744 ENPP1 ANKH ALPL
27 kidney disease 29.4 TNFRSF11B SLC12A3 REN MEFV ENPP1 CASR
28 arthropathy 29.3 TNFRSF11B NLRP3 MMP3 MMP1 IL1B HFE
29 osteomyelitis 29.3 NLRP3 MEFV IL1B CASP1
30 tenosynovitis 29.3 MMP3 IL1B
31 meningitis 29.2 NLRP3 IL1B CASP1
32 palindromic rheumatism 29.1 MEFV IL1B
33 bone disease 28.8 TNFRSF11B IL1B CASR CASP1 ANKH ALPL
34 osteoporosis 28.3 TNFRSF11B SLC12A3 MMP3 MMP1 IL1B CASR
35 arthritis 28.1 NLRP3 MMP3 MMP1 MEFV IL1B HFE
36 type 2 diabetes mellitus 27.6 TNFRSF11B REN NLRP3 MMP3 MMP1 IL1B
37 chondrocalcinosis 1 11.4
38 chondrocalcinosis due to apatite crystal deposition 11.2
39 hypomagnesemia 2, renal 10.9
40 primary hypomagnesemia 10.9
41 hyperparathyroidism 10.5
42 hemochromatosis, type 1 10.4
43 hypothyroidism 10.3
44 rheumatoid arthritis 10.3
45 back pain 10.3
46 plica syndrome 10.3
47 hemophilic arthropathy 10.3 TNFRSF11B HFE
48 calcification of joints and arteries 10.3 ENPP1 ANKH ALPL
49 primary hyperparathyroidism 10.3
50 arterial calcification of infancy 10.3 ENPP1 ANKH ALPL

Graphical network of the top 20 diseases related to Chondrocalcinosis:



Diseases related to Chondrocalcinosis

Symptoms & Phenotypes for Chondrocalcinosis

UMLS symptoms related to Chondrocalcinosis:


joint stiffness

MGI Mouse Phenotypes related to Chondrocalcinosis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.33 ALPL ANKH AP2S1 CASP1 CASR ENPP1
2 hematopoietic system MP:0005397 10.31 ALPL ANKH AP2S1 CASP1 CASR GNA11
3 homeostasis/metabolism MP:0005376 10.28 ALPL ANKH CASP1 CASR ENPP1 GNA11
4 cardiovascular system MP:0005385 10.27 ALPL ANKH AP2S1 CASP1 ENPP1 GNA11
5 immune system MP:0005387 10.24 ALPL ANKH CASP1 CASR ENPP1 GNA11
6 craniofacial MP:0005382 10.13 ALPL ANKH CASR ENPP1 GNA11 IL1B
7 mortality/aging MP:0010768 10.13 ALPL ANKH AP2S1 CASP1 CASR ENPP1
8 nervous system MP:0003631 9.97 ALPL AP2S1 CASP1 CASR ENPP1 GNA11
9 limbs/digits/tail MP:0005371 9.92 ALPL ANKH ENPP1 GNA11 HFE MYO10
10 renal/urinary system MP:0005367 9.56 CASP1 CASR ENPP1 GNA11 NLRP3 REN
11 skeleton MP:0005390 9.44 ALPL ANKH CASR ENPP1 GNA11 HFE

Drugs & Therapeutics for Chondrocalcinosis

Drugs for Chondrocalcinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Povidone Approved Phase 3 9003-39-8 131751496
2
Colchicine Approved Phase 3 64-86-8 6167 2833
3
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
4 Calcium, Dietary Phase 3
5 Antirheumatic Agents Phase 3
6 Tubulin Modulators Phase 3
7 Hormones Phase 3
8 Antimitotic Agents Phase 3
9 Hormone Antagonists Phase 3
10 glucocorticoids Phase 3
11 Anti-Inflammatory Agents Phase 3
12 Antineoplastic Agents, Hormonal Phase 3
13
Calcium Nutraceutical Phase 3 7440-70-2 271
14
Probenecid Approved, Investigational Early Phase 1 57-66-9 4911

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Non-comparative, Single Centre Study to Determine the Performance & Survivorship of the SIGMA HP® PARTIAL KNEE SYSTEM. Completed NCT01529099 Phase 4
2 Colchicine or Prednisone for the Treatment of Acute Calcium Pyrophosphate Deposition (CPPD) Arthritis: Open-label, Randomized, Multicenter, Equivalence Trial of Efficacy and Safety Recruiting NCT03128905 Phase 3 Colchicine opocalcium 1mg;Prednisone : Cortancyl 20mg
3 Study of the Role of Acid Sensing Ion Channels (ASICs) in Human Inflammatory Pain Unknown status NCT01867840
4 OMERACT Core Domain Set Selection for Calcium Pyrophosphate Deposition (CPPD): Exploring Patient and Stakeholder Perspectives on Outcome Domains Completed NCT04176003
5 Concordance Entre l'échographie du Genou et la Radiographie Standard Dans la détection Des Calcifications Dans le Cadre de la Chondrocalcinose Articulaire Completed NCT00797537
6 Appraisal of the Diagnostic Rentability of Thorough Analytical Screening Searching Associated Conditions in Patients Newly Diagnosed With Calcium Pyrophosphate Dihydrate Deposition Disease Completed NCT00453128
7 ANK-dependent ATP Efflux Causes Calcium Pyrophosphate Deposition in Cartilage Recruiting NCT02243631 Early Phase 1 Probenecid
8 Regulatory B Cells in Inflammatory Rheumatisms, Systemic Auto-immune Diseases in Adults and Biomarkers of Response to Biologic Treatments Recruiting NCT01642706
9 Data Collection for the Constitution of an Observatory for Patients Suffering From Microcrystalline Rheumatism With Morphological Phenotyping Not yet recruiting NCT04695028

Search NIH Clinical Center for Chondrocalcinosis

Genetic Tests for Chondrocalcinosis

Genetic tests related to Chondrocalcinosis:

# Genetic test Affiliating Genes
1 Chondrocalcinosis 29

Anatomical Context for Chondrocalcinosis

The Foundational Model of Anatomy Ontology organs/tissues related to Chondrocalcinosis:

19
Joint

MalaCards organs/tissues related to Chondrocalcinosis:

40
Bone, Kidney, Spinal Cord, Neutrophil, B Cells, Spleen, Monocytes

Publications for Chondrocalcinosis

Articles related to Chondrocalcinosis:

(show top 50) (show all 1704)
# Title Authors PMID Year
1
The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis. 54 61
17284543 2007
2
Investigation of the role of ENPP1 and TNAP genes in chondrocalcinosis. 61 54
17043047 2007
3
Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes. 54 61
18034874 2007
4
Role of the progressive ankylosis gene in cartilage mineralization. 61 54
16462526 2006
5
MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis. 61 54
15834054 2005
6
Association of sporadic chondrocalcinosis with a -4-basepair G-to-A transition in the 5'-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphate. 61 54
15818664 2005
7
Autosomal dominant early childhood seizures associated with chondrocalcinosis and a mutation in the ANKH Gene. 61 54
15461680 2004
8
[Chondrocalcinosis and hypomagnesaemia in a patient with a new mutation in the gene of the thiazide-sensitive Na-Cl cotransporter]. 61 54
15002785 2003
9
Crystal deposition disease of the shoulder (including calcific tendonitis and milwaukee shoulder syndrome). 54 61
12744818 2003
10
Calcium pyrophosphate dihydrate and hydroxyapatite crystal deposition in the joint: new developments relevant to the clinician. 54 61
12744817 2003
11
Mutations in ANKH cause chondrocalcinosis. 54 61
12297987 2002
12
Animal models of pathologic calcification. 61 54
11981328 2002
13
The nucleoside triphosphate pyrophosphohydrolase isozyme PC-1 directly promotes cartilage calcification through chondrocyte apoptosis and increased calcium precipitation by mineralizing vesicles. 54 61
11764218 2001
14
Can Dual-Energy Computed Tomography Be Used to Identify Early Calcium Crystal Deposition in the Knees of Patients With Calcium Pyrophosphate Deposition? 61
33131218 2021
15
Tacrolimus induced pseudogout following allogeneic hematopoietic cell transplant. 61
32819196 2021
16
Chondrocalcinosis does not affect functional outcome and prosthesis survival in patients after total or unicompartmental knee arthroplasty: a systematic review. 61
33677614 2021
17
Classifying Pseudogout Using Machine Learning Approaches With Electronic Health Record Data. 61
31910317 2021
18
Simultaneous Homozygous Mutations in SLC12A3 and CLCNKB in an Inbred Chinese Pedigree. 61
33807568 2021
19
Nodular Pseudogout of the Skull Base Arising From the Temporomandibular Joint. 61
33741871 2021
20
The Incidence and Significance of Calcium Pyrophosphate Dihydrate Deposits in Histologic Examinations of Total Hip, Knee, and Shoulder Joint Arthroplasties. 61
33720299 2021
21
Intradural calcium pyrophosphate dihydrate deposition disease: case report. 61
33668030 2021
22
Management of calcium pyrophosphate crystal deposition disease: A systematic review. 61
33360232 2021
23
Calcium Pyrophosphate Dihydrate Crystal Deposition in Gouty Tophi. 61
32909692 2021
24
[Recommendations for unicondylar knee replacement in the course of time : A current inventory]. 61
33346867 2021
25
Cervical myeloradiculopathy as an initial presentation of pseudogout. 61
33530050 2021
26
NEUTROPHIL EXTRACELLULAR TRAPS RELEASE IN GOUT AND PSEUDOGOUT DEPENDS ON THE NUMBER OF CRYSTALS REGARDLESS OF LEUKOCYTE COUNT. 61
33521820 2021
27
A Case Report of Exuberant Chondrocalcinosis of the Ankle: An Unusual Presentation. 61
33347036 2021
28
Crowned Dens Syndrome Occurring after Endoscopic Submucosal Dissection for Early Gastric Cancer. 61
33613159 2021
29
Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering. 61
33537075 2021
30
Coexistence of gout and chondrocalcinosis instead? Comment on: "Monosodium urate deposition in the articular cartilage and meniscus can mimic chondrocalcinosis" by Bousson et al. Joint Bone Spine 2020, 87:95-96. 61
32917530 2020
31
Answer to Checa « Coexistence of gout and chondrocalcinosis instead? », Joint Bone Spine 2020. doi:10.1016/j.jbspin.2020.07.007. 61
32771437 2020
32
Unilateral knee effusion in an elderly patient: an unusual presentation of rheumatoid arthritis. 61
33349329 2020
33
Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors. 61
32883636 2020
34
Arthroscopic diagnosis and medical management of calcium pyrophosphate deposition disease in the temporomandibular joint. 61
32859458 2020
35
Calcium Pyrophosphate Dihydrate Crystals Increase the Granulocyte/Monocyte Progenitor (GMP) and Enhance Granulocyte and Monocyte Differentiation In Vivo. 61
33383835 2020
36
Acute exacerbation of cervical myelopathy caused by pseudogout of the cervical ligamentum flavum after cervical spinal cord injury: a case report. 61
33139692 2020
37
Articular manifestations in patients with inflammatory bowel disease treated with vedolizumab. 61
32259251 2020
38
Prevalence of chondrocalcinosis in the temporomandibular joint in patients with chondrocalcinosis of the knee or wrist. 61
32479114 2020
39
Colchicine: An ancient drug with multiple benefits. 61
33100196 2020
40
Tophaceous pseudogout of the temporomandibular joint with erosion into the middle cranial fossa. 61
32278623 2020
41
Tophaceous pseudogout in a 12-year-old dog, with a review of applicable laboratory tests. 61
32757850 2020
42
Clinical characteristics of familial hypocalciuric hypercalcaemia type 1: A multicentre study of 77 adult patients. 61
32347971 2020
43
There is no difference in postoperative pain, function and complications in patients with chondrocalcinosis in the outcome of total knee arthroplasty for end-stage osteoarthritis. 61
31552473 2020
44
White blood cell count and total protein concentration to predict the absence of microcrystals in synovial fluid. 61
32470398 2020
45
Distinguishing Periprosthetic Crystalline Arthropathy from Infection in Total Knee Arthroplasty: A Systematic Review. 61
32942331 2020
46
[Temporomandibular sandy pseudogout: report of a case]. 61
32746558 2020
47
Acute Calcium Pyrophosphate Crystal Arthritis Flare Rate and Risk Factors for Recurrence. 61
31676701 2020
48
Acute Bilateral Pseudogout of the Temporomandibular Joint. 61
32271488 2020
49
Apolipoprotein C1 in synovial fluid discriminates septic arthritis from rheumatoid arthritis but not from pseudogout. 61
32281009 2020
50
[Inflammatory Muscle Pain: Polymyalgia Rheumatica with or without Large Vessel Vasculitis]. 61
32615604 2020

Variations for Chondrocalcinosis

ClinVar genetic disease variations for Chondrocalcinosis:

6 (show all 29)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ANKH NM_054027.6(ANKH):c.-89_-80delinsTC Indel Uncertain significance 351929 rs886060202 GRCh37: 5:14871636-14871645
GRCh38: 5:14871527-14871536
2 ANKH , OTULIN NM_054027.6(ANKH):c.*2243C>G SNV Uncertain significance 351452 rs531980160 GRCh37: 5:14709063-14709063
GRCh38: 5:14708954-14708954
3 ANKH , OTULIN NM_054027.6(ANKH):c.*5912del Deletion Uncertain significance 351395 rs765143871 GRCh37: 5:14705394-14705394
GRCh38: 5:14705285-14705285
4 ANKH , OTULIN NM_054027.6(ANKH):c.*2301del Deletion Uncertain significance 351450 rs796083754 GRCh37: 5:14709005-14709005
GRCh38: 5:14708896-14708896
5 ANKH NM_054027.6(ANKH):c.-291_-289CCG[5] Microsatellite Uncertain significance 351935 rs531421951 GRCh37: 5:14871827-14871832
GRCh38: 5:14871718-14871723
6 ANKH , OTULIN NM_054027.6(ANKH):c.*1211del Deletion Uncertain significance 351470 rs886060082 GRCh37: 5:14710095-14710095
GRCh38: 5:14709986-14709986
7 ANKH , OTULIN NM_054027.6(ANKH):c.*2113del Deletion Uncertain significance 351456 rs753413461 GRCh37: 5:14709193-14709193
GRCh38: 5:14709084-14709084
8 ANKH , OTULIN NM_054027.6(ANKH):c.*5912dup Duplication Uncertain significance 351394 rs765143871 GRCh37: 5:14705393-14705394
GRCh38: 5:14705284-14705285
9 ANKH , OTULIN NM_054027.6(ANKH):c.*1318_*1321ATTT[1] Microsatellite Uncertain significance 351467 rs886060081 GRCh37: 5:14709981-14709984
GRCh38: 5:14709872-14709875
10 ANKH NM_054027.6(ANKH):c.-291_-289CCG[6] Microsatellite Uncertain significance 351934 rs531421951 GRCh37: 5:14871827-14871829
GRCh38: 5:14871718-14871720
11 ANKH NM_054027.6(ANKH):c.-128_-80delinsCGC Indel Uncertain significance 351930 rs886060203 GRCh37: 5:14871636-14871684
GRCh38: 5:14871527-14871575
12 ANKH NM_054027.6(ANKH):c.-80_-79insC Insertion Uncertain significance 351928 rs886060201 GRCh37: 5:14871635-14871636
GRCh38: 5:14871526-14871527
13 ANKH , OTULIN NM_054027.6(ANKH):c.*5034del Deletion Uncertain significance 351408 rs541644826 GRCh37: 5:14706272-14706272
GRCh38: 5:14706163-14706163
14 ANKH NM_054027.6(ANKH):c.-291_-289CCG[9] Microsatellite Uncertain significance 351933 rs531421951 GRCh37: 5:14871826-14871827
GRCh38: 5:14871717-14871718
15 ANKH , OTULIN NM_054027.6(ANKH):c.*695_*698dup Duplication Likely benign 351485 rs555469650 GRCh37: 5:14710607-14710608
GRCh38: 5:14710498-14710499
16 ANKH , OTULIN NM_054027.6(ANKH):c.*3336_*3339del Deletion Likely benign 351438 rs377752827 GRCh37: 5:14707967-14707970
GRCh38: 5:14707858-14707861
17 ANKH , OTULIN NM_054027.6(ANKH):c.*1948_*1949del Deletion Likely benign 351458 rs527743958 GRCh37: 5:14709357-14709358
GRCh38: 5:14709248-14709249
18 ANKH , OTULIN NM_054027.6(ANKH):c.*2974G>A SNV Likely benign 351439 rs182073449 GRCh37: 5:14708332-14708332
GRCh38: 5:14708223-14708223
19 ANKH , OTULIN NM_054027.6(ANKH):c.*5136del Deletion Likely benign 351407 rs577325072 GRCh37: 5:14706170-14706170
GRCh38: 5:14706061-14706061
20 ANKH NM_054027.6(ANKH):c.-291_-289CCG[8] Microsatellite Likely benign 351932 rs531421951 GRCh37: 5:14871826-14871827
GRCh38: 5:14871717-14871718
21 ANKH , OTULIN NM_054027.6(ANKH):c.*1887dup Duplication Likely benign 351460 rs201158874 GRCh37: 5:14709418-14709419
GRCh38: 5:14709309-14709310
22 ANKH , OTULIN NM_054027.6(ANKH):c.*416_*419dup Duplication Likely benign 351491 rs142033023 GRCh37: 5:14710886-14710887
GRCh38: 5:14710777-14710778
23 ANKH , OTULIN NM_054027.6(ANKH):c.*3928_*3929del Deletion Benign 351423 rs527918862 GRCh37: 5:14707377-14707378
GRCh38: 5:14707268-14707269
24 ANKH , OTULIN NM_054027.6(ANKH):c.*3900del Deletion Benign 351425 rs34717032 GRCh37: 5:14707406-14707406
GRCh38: 5:14707297-14707297
25 ANKH , OTULIN NM_054027.6(ANKH):c.*939_*942dup Duplication Benign 351474 rs71603731 GRCh37: 5:14710363-14710364
GRCh38: 5:14710254-14710255
26 ANKH NM_054027.6(ANKH):c.-80_-73GTCGCCCC[1] Microsatellite Benign 351927 rs139106733 GRCh37: 5:14871621-14871628
GRCh38: 5:14871512-14871519
27 ANKH , OTULIN NM_054027.6(ANKH):c.*2301dup Duplication Benign 351449 rs796083754 GRCh37: 5:14709004-14709005
GRCh38: 5:14708895-14708896
28 ANKH , OTULIN NM_054027.6(ANKH):c.*5281del Deletion Benign 351406 rs34917282 GRCh37: 5:14706025-14706025
GRCh38: 5:14705916-14705916
29 ANKH , OTULIN NM_054027.6(ANKH):c.*1893dup Duplication Benign 351459 rs34294961 GRCh37: 5:14709412-14709413
GRCh38: 5:14709303-14709304

Expression for Chondrocalcinosis

Search GEO for disease gene expression data for Chondrocalcinosis.

Pathways for Chondrocalcinosis

GO Terms for Chondrocalcinosis

Cellular components related to Chondrocalcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 TNFRSF11B REN NLRP3 MMP3 MMP1 IL1B
2 extracellular matrix GO:0031012 9.46 TNFRSF11B MMP3 MMP1 ALPL
3 NLRP3 inflammasome complex GO:0072559 8.62 NLRP3 CASP1

Biological processes related to Chondrocalcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 MMP3 MMP1 IL1B CASP1
2 response to lipopolysaccharide GO:0032496 9.56 REN IL1B CASP1 ALPL
3 cellular response to UV-A GO:0071492 9.32 MMP3 MMP1
4 sequestering of triglyceride GO:0030730 9.16 IL1B ENPP1
5 inorganic diphosphate transport GO:0030505 8.96 ENPP1 ANKH
6 skeletal system development GO:0001501 8.92 TNFRSF11B GNA11 ANKH ALPL

Molecular functions related to Chondrocalcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.35 REN OTULIN MMP3 MMP1 CASP1
2 endopeptidase activity GO:0004175 8.92 REN MMP3 MMP1 CASP1

Sources for Chondrocalcinosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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