MCID: CHN059
MIFTS: 52

Chondrocalcinosis

Categories: Bone diseases, Genetic diseases, Rare diseases
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Aliases & Classifications for Chondrocalcinosis

MalaCards integrated aliases for Chondrocalcinosis:

Name: Chondrocalcinosis 11 75 28 53 5 14 33
Pseudogout 11 75 53 71
Calcium Pyrophosphate Deposition Disease 11 71 33
Chondrocalcinosis, Due to Pyrophosphate Crystals, Involving Unspecified Site 33
Cppd - [calcium Pyrophosphate Deposition Disease] 33
Cpdd - [calcium Pyrophosphate Deposition Disease] 33
Calcium Pyrophosphate Arthritis and Periarthritis 33
Chondrocalcinosis Due to Pyrophosphate Crystals 33
Chondrocalcinosis, Cause Unspecified 33
Chondrocalcinosis Articularis 33
Familial Chondrocalcinosis 33
Chondrocalcinosis Nos 33

Classifications:



External Ids:

Disease Ontology 11 DOID:1156
ICD9CM 34 712.1
NCIt 49 C34955
SNOMED-CT 68 201624004 201625003
ICD11 33 2041797033
UMLS 71 C0033802 C0157852 C0553730

Summaries for Chondrocalcinosis

Disease Ontology: 11 An arthritis that has material basis in the accumulation of salt crystals located in joint.

MalaCards based summary: Chondrocalcinosis, also known as pseudogout, is related to familial calcium pyrophosphate deposition and gitelman syndrome, and has symptoms including joint stiffness An important gene associated with Chondrocalcinosis is CCAL1 (Chondrocalcinosis 1 (Calcium Pyrophosphate-Deposition Disease, Early Onset Osteoarthritis)), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and Inflammasomes. The drugs Prednisone and Povidone K30 have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and b cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia 75 Chondrocalcinosis: Chondrocalcinosis or cartilage calcification is calcification (accumulation of calcium salts) in hyaline... more...

Pseudogout: Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and... more...

Related Diseases for Chondrocalcinosis

Diseases in the Chondrocalcinosis family:

Chondrocalcinosis 2 Chondrocalcinosis Due to Apatite Crystal Deposition
Chondrocalcinosis 1

Diseases related to Chondrocalcinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 402)
# Related Disease Score Top Affiliating Genes
1 familial calcium pyrophosphate deposition 32.6 TNFRSF11B ANKH
2 gitelman syndrome 32.0 SLC12A3 REN CASR
3 hypophosphatasia, adult 31.5 PTH ENPP1 ANKH ALPL
4 hypocalciuric hypercalcemia, familial, type i 31.4 PTH GNA11 CASR AP2S1
5 hypocalciuric hypercalcemia, familial, type ii 31.4 PTH GNA11 CASR AP2S1
6 familial hypocalciuric hypercalcemia 31.2 PTH GNA11 CASR AP2S1
7 hypocalciuric hypercalcemia, familial, type iii 31.1 PTH GNA11 CASR AP2S1
8 hyperparathyroidism 30.8 TNFRSF11B PTH CASR
9 hypokalemia 30.6 SLC12A3 REN CASR
10 hyperostosis 30.6 TNFRSF11B ANKH ALPL
11 tendinopathy 30.5 MMP3 MMP1
12 osteoarthritis 30.4 TNFRSF11B MMP3 MMP1 IL1B CRP
13 bartter disease 30.4 SLC12A3 REN PTH CASR
14 hypophosphatasia 30.3 PTH ENPP1 ANKH ALPL
15 cartilage disease 30.3 MMP3 IL1B CRP
16 primary hyperparathyroidism 30.2 PTH GNA11 CASR AP2S1
17 arterial calcification of infancy 30.1 ENPP1 ANKH ALPL
18 hypercalcemia, infantile, 1 30.1 PTH CASR
19 back pain 30.1 MMP3 MMP1 IL1B CRP
20 periarthritis 30.0 PTH ALPL
21 septic arthritis 30.0 MMP3 IL1B CRP
22 parathyroid adenoma 29.9 PTH CASR AP2S1
23 bartter syndrome, type 3 29.9 SLC12A3 REN CASR
24 craniometaphyseal dysplasia, autosomal dominant 29.9 TNFRSF11B ENPP1 ANKH ALPL
25 ankylosis 29.9 TNFRSF11B ENPP1 CRP ANKH ALPL
26 secondary hyperparathyroidism 29.8 TNFRSF11B PTH CASR
27 nephrocalcinosis 29.8 SLC12A3 GNA11 CASR
28 urinary tract infection 29.8 REN IL1B CRP
29 synovitis 29.8 TNFRSF11B MMP3 MMP1 IL1B CRP
30 bone disease 29.6 TNFRSF11B PTH CASR ALPL
31 arthropathy 29.6 TNFRSF11B NLRP3 MMP3 MMP1 IL1B HFE
32 osteomalacia 29.5 PTH ENPP1 CASR ALPL
33 spondylolisthesis 29.5 PTH MMP3 CRP
34 neurogenic arthropathy 29.4 NAA30 CRP
35 tenosynovitis 29.4 MMP3 IL1B CRP
36 tendinitis 29.4 MMP3 IL1B CRP
37 enthesopathy 29.4 PTH ENPP1 CRP ALPL
38 hyperuricemia 29.3 REN PTH NLRP3 CRP
39 osteomyelitis 29.3 NLRP3 MMP1 IL1B CRP CASP1 ALPL
40 proteasome-associated autoinflammatory syndrome 1 29.2 NLRP3 IL1B CRP
41 periodic fever, familial, autosomal dominant 29.2 NLRP3 IL1B CRP CASP1
42 meningitis 29.2 NLRP3 IL1B CRP CASP1
43 bursitis 29.2 PTH IL1B CRP ALPL
44 spondyloarthropathy 1 29.2 TNFRSF11B PTH MMP3 IL1B CRP ANKH
45 conn's syndrome 29.1 SLC12A3 REN PTH CRP CASR
46 hyperphosphatemia 29.1 TNFRSF11B PTH CRP CASR
47 kidney disease 29.0 TNFRSF11B SLC12A3 REN PTH ENPP1 CRP
48 crohn's disease 28.9 NLRP3 IL1B CRP CASP1
49 psoriatic arthritis 28.9 TNFRSF11B MMP3 MMP1 IL1B CRP
50 bone resorption disease 28.9 PTH IL1B CRP

Graphical network of the top 20 diseases related to Chondrocalcinosis:



Diseases related to Chondrocalcinosis

Symptoms & Phenotypes for Chondrocalcinosis

UMLS symptoms related to Chondrocalcinosis:


joint stiffness

GenomeRNAi Phenotypes related to Chondrocalcinosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 IL1B NLRP3 PTH REN TNFRSF11B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CASP1 ENPP1 IL1B NLRP3 PTH REN

MGI Mouse Phenotypes related to Chondrocalcinosis:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 ALPL ANKH CASP1 CASR CRP ENPP1
2 nervous system MP:0003631 10.27 ALPL AP2S1 CASP1 ENPP1 GNA11 HFE
3 growth/size/body region MP:0005378 10.25 ALPL ANKH AP2S1 CASP1 CASR ENPP1
4 cardiovascular system MP:0005385 10.13 ALPL ANKH AP2S1 CASP1 CRP ENPP1
5 immune system MP:0005387 10.13 ALPL ANKH CASP1 CASR CRP ENPP1
6 limbs/digits/tail MP:0005371 10.11 ALPL ANKH ENPP1 GNA11 HFE MYO10
7 renal/urinary system MP:0005367 10.08 CASP1 CASR ENPP1 GNA11 NLRP3 REN
8 craniofacial MP:0005382 9.97 ALPL ANKH ENPP1 GNA11 IL1B MYO10
9 skeleton MP:0005390 9.93 ALPL ANKH CASR ENPP1 GNA11 HFE
10 hematopoietic system MP:0005397 9.73 ALPL ANKH CASP1 CASR GNA11 HFE
11 mortality/aging MP:0010768 9.47 ALPL ANKH AP2S1 CASP1 CASR ENPP1

Drugs & Therapeutics for Chondrocalcinosis

Drugs for Chondrocalcinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
2
Povidone K30 Approved, Experimental Phase 3 9003-39-8 6917 131751496
3
Colchicine Approved Phase 3 64-86-8 2833 6167
4 Calcium, Dietary Phase 3
5 glucocorticoids Phase 3
6 Tubulin Modulators Phase 3
7 Antineoplastic Agents, Hormonal Phase 3
8 Antimitotic Agents Phase 3
9 Antirheumatic Agents Phase 3
10 Hormones Phase 3
11 Hormone Antagonists Phase 3
12 Anti-Inflammatory Agents Phase 3
13
Calcium Nutraceutical Phase 3 7440-70-2 271
14
Probenecid Approved, Investigational Early Phase 1 57-66-9 4911

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Non-comparative, Single Centre Study to Determine the Performance & Survivorship of the SIGMA HP® PARTIAL KNEE SYSTEM. Completed NCT01529099 Phase 4
2 Colchicine or Prednisone for the Treatment of Acute Calcium Pyrophosphate Deposition (CPPD) Arthritis: Open-label, Randomized, Multicenter, Equivalence Trial of Efficacy and Safety Recruiting NCT03128905 Phase 3 Colchicine opocalcium 1mg;Prednisone : Cortancyl 20mg
3 Study of the Role of Acid Sensing Ion Channels (ASICs) in Human Inflammatory Pain Unknown status NCT01867840
4 Regulatory B Cells in Inflammatory Rheumatisms, Systemic Auto-immune Diseases in Adults and Biomarkers of Response to Biologic Treatments Unknown status NCT01642706
5 Concordance Entre l'échographie du Genou et la Radiographie Standard Dans la détection Des Calcifications Dans le Cadre de la Chondrocalcinose Articulaire Completed NCT00797537
6 Appraisal of the Diagnostic Rentability of Thorough Analytical Screening Searching Associated Conditions in Patients Newly Diagnosed With Calcium Pyrophosphate Dihydrate Deposition Disease Completed NCT00453128
7 ANK-dependent ATP Efflux Causes Calcium Pyrophosphate Deposition in Cartilage Completed NCT02243631 Early Phase 1 Probenecid
8 OMERACT Core Domain Set Selection for Calcium Pyrophosphate Deposition (CPPD): Exploring Patient and Stakeholder Perspectives on Outcome Domains Completed NCT04176003
9 Data Collection for the Constitution of an Observatory for Patients Suffering From Microcrystalline Rheumatism With Morphological Phenotyping Not yet recruiting NCT04695028

Search NIH Clinical Center for Chondrocalcinosis

Genetic Tests for Chondrocalcinosis

Genetic tests related to Chondrocalcinosis:

# Genetic test Affiliating Genes
1 Chondrocalcinosis 28

Anatomical Context for Chondrocalcinosis

Organs/tissues related to Chondrocalcinosis:

FMA: Joint
MalaCards : Bone, B Cells, Spinal Cord, Neutrophil, Thyroid, Kidney, Liver

Publications for Chondrocalcinosis

Articles related to Chondrocalcinosis:

(show top 50) (show all 1921)
# Title Authors PMID Year
1
The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis. 53 62
17284543 2007
2
Investigation of the role of ENPP1 and TNAP genes in chondrocalcinosis. 53 62
17043047 2007
3
Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes. 53 62
18034874 2007
4
Role of the progressive ankylosis gene in cartilage mineralization. 53 62
16462526 2006
5
MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis. 53 62
15834054 2005
6
Association of sporadic chondrocalcinosis with a -4-basepair G-to-A transition in the 5'-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphate. 53 62
15818664 2005
7
Autosomal dominant early childhood seizures associated with chondrocalcinosis and a mutation in the ANKH Gene. 53 62
15461680 2004
8
[Chondrocalcinosis and hypomagnesaemia in a patient with a new mutation in the gene of the thiazide-sensitive Na-Cl cotransporter]. 53 62
15002785 2003
9
Crystal deposition disease of the shoulder (including calcific tendonitis and milwaukee shoulder syndrome). 53 62
12744818 2003
10
Calcium pyrophosphate dihydrate and hydroxyapatite crystal deposition in the joint: new developments relevant to the clinician. 53 62
12744817 2003
11
Mutations in ANKH cause chondrocalcinosis. 53 62
12297987 2002
12
Animal models of pathologic calcification. 53 62
11981328 2002
13
The nucleoside triphosphate pyrophosphohydrolase isozyme PC-1 directly promotes cartilage calcification through chondrocyte apoptosis and increased calcium precipitation by mineralizing vesicles. 53 62
11764218 2001
14
Pseudogout growing from the temporomandibular joint into the middle cranial fossa. 62
36194300 2022
15
Chondrocalcinosis Under Diagnostic Ultrasound in a Recreational Tennis Player. 62
35440523 2022
16
Identifying Potential Classification Criteria for Calcium Pyrophosphate Deposition Disease: Item Generation and Item Reduction. 62
33973414 2022
17
Ultrasound findings of calcium pyrophosphate deposition disease at metacarpophalangeal joints. 62
35104308 2022
18
Treatment of tophaceous pseudogout in the temporomandibular joint with resection and alloplastic reconstruction: a single-staged approach. 62
34596805 2022
19
Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine ZnII complex. 62
36172837 2022
20
Calcium pyrophosphate dihydrate crystals in a 9-year-old with osteomyelitis of the knee: A case report. 62
36189334 2022
21
Imaging of Atlantoaxial Calcium Pyrophosphate Dihydrate Deposition With Unusual Onset as Drop Attack. 62
36109071 2022
22
[Prevalence of hypophosphatasia in adult patients in rheumatology]. 62
33852075 2022
23
Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors. 62
35936461 2022
24
Risk factors for septic arthritis and multiple arthroscopic washouts: minimum 2-year follow-up at a major trauma centre. 62
35366159 2022
25
Teaching Neuroimage: Crowned Dens Syndrome, an Acute Attack of Calcium Pyrophosphate Deposition Disease Mimicking Acute Meningitis. 62
35790420 2022
26
Outcomes and resource utilization in calcium pyrophosphate deposition disease patients who underwent total knee arthroplasty: a cross-sectional analysis. 62
35175448 2022
27
High prevalence of chondrocalcinosis and frequent comorbidity with calcium pyrophosphate deposition disease in patients with seronegative rheumatoid arthritis. 62
35701012 2022
28
Calcium pyrophosphate crystal deposition in a cohort of 57 patients with Gitelman syndrome. 62
34508565 2022
29
Calcium pyrophosphate crystals in L4-L5 facet joint from small fluid sample. 62
35509330 2022
30
Risk of cardiovascular events in patients having had acute calcium pyrophosphate crystal arthritis. 62
35613842 2022
31
Distinguishing Periprosthetic Crystalline Arthropathy from Infection in Total Knee Arthroplasty: A Systematic Review. 62
32942331 2022
32
Septic and Crystal-Induced Arthritis (Pseudogout) Post-COVID-19 Vaccination. 62
35530843 2022
33
Colchicine Against SARS-CoV-2 Infection: What is the Evidence? 62
35107804 2022
34
Pseudogout as a Cause of Fever of Unknown Origin Following Staphylococcal Bacteremia in an Older Patient. 62
35607560 2022
35
Gout in Primary Hyperparathyroidism, Connecting Crystals to the Minerals. 62
35261933 2022
36
Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization. 62
35412619 2022
37
Chondrocalcinosis does not affect functional outcome and prosthesis survival in patients after total or unicompartmental knee arthroplasty: a systematic review. 62
33677614 2022
38
Tophaceous pseudogout of the temporomandibular joint extending into the cranium: a case report with literature review. 62
35265318 2022
39
Chemical Diagnosis of Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint: A Case Report. 62
35328204 2022
40
Calcium pyrophosphate deposition disease involving "the largest" Bursa in the human body. 62
34057674 2022
41
Unusual calcium pyrophosphate deposition disease. 62
34009268 2022
42
Calcium pyrophosphate dihydrate crystal deposition disease and retro-odontoid pseudotumor rupture managed via posterior occipital cervical instrumented fusion: illustrative case. 62
36130550 2022
43
Sensing and imaging of PPi in vivo using lanthanide-based second near-infrared luminescent probes. 62
35103275 2022
44
Augustine Blood Group System and Equilibrative Nucleoside Transporter 1. 62
35221865 2022
45
Knee Arthrocentesis in Adults. 62
35285829 2022
46
The role of TNFRSF11B in development of osteoarthritic cartilage. 62
33989379 2022
47
Sclerochoroidal calcification associated with chondrocalcinosis: A clinical case. 62
35145663 2022
48
Pseudogout, an unconventional imitator of the lumbosacral spine with associated chronic epidural hematoma: illustrative cases. 62
36130549 2022
49
Identification of Common Pathogenic Pathways Involved in Hemochromatosis Arthritis and Calcium Pyrophosphate Deposition Disease: a Review. 62
35143028 2022
50
Hereditary haemochromatosis presenting to rheumatology clinic as inflammatory arthritis. 62
35039359 2022

Variations for Chondrocalcinosis

ClinVar genetic disease variations for Chondrocalcinosis:

5 (show all 24)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ANKH NM_054027.6(ANKH):c.-89_-80delinsTC INDEL Uncertain Significance
351929 rs886060202 GRCh37: 5:14871636-14871645
GRCh38: 5:14871527-14871536
2 ANKH, OTULIN NM_054027.6(ANKH):c.*2243C>G SNV Uncertain Significance
351452 rs531980160 GRCh37: 5:14709063-14709063
GRCh38: 5:14708954-14708954
3 ANKH NM_054027.6(ANKH):c.-291CCG[5] MICROSAT Uncertain Significance
Uncertain Significance
Uncertain Significance
Likely Benign
351935 rs531421951 GRCh37: 5:14871827-14871832
GRCh38: 5:14871718-14871723
4 ANKH, OTULIN NM_054027.6(ANKH):c.*1211del DEL Uncertain Significance
351470 rs886060082 GRCh37: 5:14710095-14710095
GRCh38: 5:14709986-14709986
5 ANKH, OTULIN NM_054027.6(ANKH):c.*2113del DEL Uncertain Significance
351456 rs753413461 GRCh37: 5:14709193-14709193
GRCh38: 5:14709084-14709084
6 ANKH, OTULIN NM_054027.6(ANKH):c.*5912dup DUP Uncertain Significance
Uncertain Significance
351394 rs765143871 GRCh37: 5:14705393-14705394
GRCh38: 5:14705284-14705285
7 ANKH, OTULIN NM_054027.6(ANKH):c.*1318ATTT[1] MICROSAT Uncertain Significance
351467 rs886060081 GRCh37: 5:14709981-14709984
GRCh38: 5:14709872-14709875
8 ANKH NM_054027.6(ANKH):c.-128_-80delinsCGC INDEL Uncertain Significance
351930 rs886060203 GRCh37: 5:14871636-14871684
GRCh38: 5:14871527-14871575
9 ANKH NM_054027.6(ANKH):c.-80_-79insC INSERT Uncertain Significance
351928 rs886060201 GRCh37: 5:14871635-14871636
GRCh38: 5:14871526-14871527
10 ANKH, OTULIN NM_054027.6(ANKH):c.*2301del DEL Uncertain Significance
Benign
351450 rs796083754 GRCh37: 5:14709005-14709005
GRCh38: 5:14708896-14708896
11 ANKH, OTULIN NM_054027.6(ANKH):c.*5034del DEL Uncertain Significance
351408 rs541644826 GRCh37: 5:14706272-14706272
GRCh38: 5:14706163-14706163
12 ANKH, OTULIN NM_054027.6(ANKH):c.*416_*419dup DUP Likely Benign
351491 rs142033023 GRCh37: 5:14710886-14710887
GRCh38: 5:14710777-14710778
13 ANKH, OTULIN NM_054027.6(ANKH):c.*695_*698dup DUP Likely Benign
351485 rs555469650 GRCh37: 5:14710607-14710608
GRCh38: 5:14710498-14710499
14 ANKH, OTULIN NM_054027.6(ANKH):c.*3336_*3339del DEL Likely Benign
351438 rs377752827 GRCh37: 5:14707967-14707970
GRCh38: 5:14707858-14707861
15 ANKH, OTULIN NM_054027.6(ANKH):c.*1948_*1949del DEL Likely Benign
351458 rs527743958 GRCh37: 5:14709357-14709358
GRCh38: 5:14709248-14709249
16 ANKH, OTULIN NM_054027.6(ANKH):c.*2974G>A SNV Likely Benign
351439 rs182073449 GRCh37: 5:14708332-14708332
GRCh38: 5:14708223-14708223
17 ANKH, OTULIN NM_054027.6(ANKH):c.*5136del DEL Likely Benign
351407 rs577325072 GRCh37: 5:14706170-14706170
GRCh38: 5:14706061-14706061
18 ANKH, OTULIN NM_054027.6(ANKH):c.*1887dup DUP Likely Benign
351460 rs201158874 GRCh37: 5:14709418-14709419
GRCh38: 5:14709309-14709310
19 ANKH, OTULIN NM_054027.6(ANKH):c.*3928_*3929del DEL Benign
351423 rs527918862 GRCh37: 5:14707377-14707378
GRCh38: 5:14707268-14707269
20 ANKH, OTULIN NM_054027.6(ANKH):c.*3900del DEL Benign
351425 rs34717032 GRCh37: 5:14707406-14707406
GRCh38: 5:14707297-14707297
21 ANKH, OTULIN NM_054027.6(ANKH):c.*939_*942dup DUP Benign
351474 rs71603731 GRCh37: 5:14710363-14710364
GRCh38: 5:14710254-14710255
22 ANKH, OTULIN NM_054027.6(ANKH):c.*5281del DEL Benign
351406 rs34917282 GRCh37: 5:14706025-14706025
GRCh38: 5:14705916-14705916
23 ANKH, OTULIN NM_054027.6(ANKH):c.*1893dup DUP Benign
351459 rs34294961 GRCh37: 5:14709412-14709413
GRCh38: 5:14709303-14709304
24 ANKH NM_054027.6(ANKH):c.-80GTCGCCCC[1] MICROSAT Benign
351927 rs139106733 GRCh37: 5:14871621-14871628
GRCh38: 5:14871512-14871519

Expression for Chondrocalcinosis

Search GEO for disease gene expression data for Chondrocalcinosis.

Pathways for Chondrocalcinosis

GO Terms for Chondrocalcinosis

Cellular components related to Chondrocalcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.62 TNFRSF11B REN PTH NLRP3 MMP3 MMP1

Biological processes related to Chondrocalcinosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.96 ALPL ANKH GNA11 PTH TNFRSF11B
2 calcium ion homeostasis GO:0055074 9.83 PTH ANKH ALPL
3 response to sodium phosphate GO:1904383 9.8 ANKH ALPL
4 response to fibroblast growth factor GO:0071774 9.78 PTH CASR
5 bone mineralization GO:0030282 9.76 PTH ENPP1 ANKH ALPL
6 cementum mineralization GO:0071529 9.71 ANKH ALPL
7 sequestering of triglyceride GO:0030730 9.67 IL1B ENPP1
8 osmosensory signaling pathway GO:0007231 9.63 NLRP3 CASP1
9 inorganic diphosphate transport GO:0030505 9.62 ENPP1 ANKH
10 biomineralization GO:0110148 9.26 ENPP1 ANKH ALPL
11 phosphate ion homeostasis GO:0055062 9.23 PTH ENPP1 ANKH ALPL

Molecular functions related to Chondrocalcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.17 REN MMP3 MMP1 CASP1

Sources for Chondrocalcinosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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