MCID: CHN009
MIFTS: 32

Chondroid Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Chondroid Chordoma

MalaCards integrated aliases for Chondroid Chordoma:

Name: Chondroid Chordoma 12 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4152
NCIt 51 C6902
UMLS 74 C1266173

Summaries for Chondroid Chordoma

Disease Ontology : 12 A chordoma that histologically derives from chordoma, derives from chondroma, and derives from chondrosarcoma.

MalaCards based summary : Chondroid Chordoma is related to chordoma and clivus chondroid chordoma. An important gene associated with Chondroid Chordoma is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cell surface interactions at the vascular wall. Affiliated tissues include bone, pituitary and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chondroid Chordoma

Diseases related to Chondroid Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 chordoma 30.6 CDH1 CEACAM3 MUC1 S100A1 SMARCB1 VIM
2 clivus chondroid chordoma 12.8
3 hidradenoma 10.5 MUC1 VIM
4 malignant peritoneal mesothelioma 10.4 MUC1 VIM
5 parachordoma 10.4 MUC1 VIM
6 secretory meningioma 10.4 MUC1 VIM
7 syringocystadenoma papilliferum 10.4 MUC1 VIM
8 fibrous meningioma 10.4 MUC1 VIM
9 chordoid meningioma 10.4 MUC1 VIM
10 eccrine porocarcinoma 10.4 MUC1 VIM
11 endometrial mucinous adenocarcinoma 10.4 MUC1 VIM
12 adenofibroma 10.4 MUC1 VIM
13 clear cell meningioma 10.4 MUC1 VIM
14 myxopapillary ependymoma 10.4 MUC1 VIM
15 monophasic synovial sarcoma 10.4 MUC1 VIM
16 syringoma 10.4 MUC1 VIM
17 pleomorphic liposarcoma 10.4 MUC1 VIM
18 perivascular epithelioid cell tumor 10.4 MUC1 VIM
19 anaplastic ependymoma 10.4 MUC1 VIM
20 sertoli cell tumor 10.4 MUC1 VIM
21 ischemic fasciitis 10.4 MUC1 S100A1
22 mesenchymal chondrosarcoma 10.4 MUC1 VIM
23 perineurioma 10.4 MUC1 VIM
24 dermoid cyst 10.3 MUC1 VIM
25 rhabdoid meningioma 10.3 SMARCB1 VIM
26 spindle cell sarcoma 10.3 MUC1 VIM
27 reticulum cell sarcoma 10.3 MUC1 S100A1 VIM
28 apocrine adenoma 10.3 CEACAM5 MUC1
29 mucinous cystadenocarcinoma 10.3 MUC1 VIM
30 breast mucoepidermoid carcinoma 10.3 CEACAM5 MUC1
31 cavernous hemangioma 10.3 MUC1 S100A1 VIM
32 bile duct mucoepidermoid carcinoma 10.3 CEACAM5 MUC1
33 bile duct cystadenocarcinoma 10.3 CEACAM5 MUC1
34 anal paget's disease 10.2 CEACAM5 MFGE8
35 pilomatrix carcinoma 10.2 ENO2 MUC1
36 intracranial cysts 10.2 ENO2 MUC1
37 epulis 10.2 ENO2 VIM
38 chondrosarcoma 10.2
39 anus adenocarcinoma 10.2 CEACAM5 MFGE8
40 middle ear adenoma 10.2 ENO2 MUC1
41 microcystic adenoma 10.2 ENO2 MUC1
42 bednar tumor 10.2 ENO2 VIM
43 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 VIM
44 rhabdoid tumor predisposition syndrome 1 10.2 MUC1 SMARCB1 VIM
45 dendritic cell tumor 10.2 MUC1 VIM
46 epithelioid sarcoma 10.2 MUC1 SMARCB1 VIM
47 biliary papillomatosis 10.2 CEACAM5 MUC1
48 gallbladder small cell carcinoma 10.2 CEACAM3 ENO2
49 epithelioid leiomyosarcoma 10.2 ENO2 VIM
50 malignant ectomesenchymoma 10.2 ENO2 S100A1

Graphical network of the top 20 diseases related to Chondroid Chordoma:



Diseases related to Chondroid Chordoma

Symptoms & Phenotypes for Chondroid Chordoma

GenomeRNAi Phenotypes related to Chondroid Chordoma according to GeneCards Suite gene sharing:

27 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.77 SMARCB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.77 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.77 SMARCB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.77 MAP2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.77 SMARCB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.77 EPCAM
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.77 VIM
8 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.77 EPCAM
9 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.77 EPCAM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.77 EPCAM MAP2 SMARCB1 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.77 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.77 VIM
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.77 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.77 SMARCB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.77 EPCAM MAP2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.77 VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.77 VIM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.77 EPCAM VIM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.77 EPCAM
20 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 SMARCB1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 SMARCB1 VIM
22 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.77 EPCAM

Drugs & Therapeutics for Chondroid Chordoma

Search Clinical Trials , NIH Clinical Center for Chondroid Chordoma

Genetic Tests for Chondroid Chordoma

Anatomical Context for Chondroid Chordoma

MalaCards organs/tissues related to Chondroid Chordoma:

42
Bone, Pituitary, Breast, Kidney, Liver, Ovary, Testis

Publications for Chondroid Chordoma

Articles related to Chondroid Chordoma:

(show top 50) (show all 60)
# Title Authors Year
1
A unique case of eyelid metastasis from chondroid chordoma. ( 30971557 )
2019
2
Clival Chondroid Chordoma: A Case Report and Review of the Literature. ( 30519520 )
2018
3
A unique case of distant skin metastasis from chondroid chordoma. ( 27051831 )
2016
4
Chondroid chordoma of the sella turcica mimicking a pituitary adenoma. ( 26535833 )
2015
5
Skull base chondroid chordoma: atypical case manifesting as intratumoral hemorrhage and literature review. ( 25070287 )
2014
6
Chondroid chordoma in an atypical location. ( 23791243 )
2013
7
Endoscopic management of a lower clival chondroid chordoma: case report. ( 22274986 )
2012
8
Chondroid chordoma and nasal adenocarcinoma: an exceptional association. ( 23024872 )
2012
9
Endonasal endoscopic approach for the resection of chondroid chordoma with skull base involvement. ( 21959419 )
2011
10
Cervical chondroid chordoma in a standard dachshund: a case report. ( 22017812 )
2011
11
Intrasellar chondroid chordoma: a case report. ( 22500242 )
2011
12
Dumbbell-shaped thoracic chondroid chordoma mimicking a neurinoma. ( 19415177 )
2010
13
Adjuvant radiation therapy and chondroid chordoma subtype are associated with a lower tumor recurrence rate of cranial chordoma. ( 19953297 )
2010
14
Intradural suprasellar chondroid chordoma. ( 20074956 )
2010
15
Chondroid chordoma of the skull base: immunohistochemical and ultrastructural study of two cases with special reference to microtubules within rough-surfaced endoplasmic reticulum. ( 21267702 )
2010
16
Cervical chondroid chordoma in a Shetland sheep dog. ( 18374350 )
2008
17
Chondroid chordoma of petrous temporal bone with extensive recurrence and pulmonary metastases. ( 18688126 )
2008
18
A case of coccygeal chondroid chordoma in a cat: morphological and immunohistochemical features. ( 18776111 )
2008
19
Chondroid chordoma of the thoracic spine: case report. ( 17454766 )
2007
20
Chondroid chordoma of the L5 spinous process and lamina: a case report. ( 15895260 )
2005
21
Craniospinal dissemination of clival chondroid chordoma. ( 16333198 )
2005
22
Chondroid chordoma at the jugular foramen causing retrolabyrinthine lesions in both the cochlear and vestibular branches of the eighth cranial nerve. ( 14763580 )
2004
23
Chondroid chordoma of the nasal septum. ( 12578458 )
2003
24
Primary chondroid chordoma of the petrous part of the temporal bone. ( 14524492 )
2003
25
Chondroid chordoma of the cervical spine. ( 12382136 )
2002
26
Chondroid chordoma of the lateral skull base. ( 11244373 )
2001
27
Drop metastases in a patient with a chondroid chordoma of the clivus. ( 10450844 )
1999
28
Chondroid chordoma: fine-needle aspiration cytology with histopathological, immunohistochemical, and ultrastructural study of two cases. ( 10527481 )
1999
29
Hemorrhagic chondroid chordoma mimicking pituitary apoplexy. ( 9860121 )
1998
30
Intraoperative squash and touch cytology of chondroid chordoma of the skull base. Report of a case with immunocytochemical and immunohistochemical studies. ( 9167726 )
1997
31
Spheno-occipital chondroid chordoma. ( 9176805 )
1997
32
Intracranial chondroid chordoma. ( 18638963 )
1997
33
SELLAR CHONDROID CHORDOMA: A Case Report. ( 28769413 )
1996
34
Chondroid chordoma base of skull. ( 29542540 )
1996
35
Chondroid chordoma. A hyalinized chordoma without cartilaginous differentiation. ( 7532910 )
1995
36
Chondroid chordoma. ( 7572805 )
1995
37
Intracisternal microtubular aggregates in classic (non chondroid) chordoma. ( 7671211 )
1995
38
Chondroid chordoma of the lateral skull base. ( 8751297 )
1995
39
Chondroid chordoma--a variant of chordoma. A morphologic and immunohistochemical study. ( 7506477 )
1994
40
Chondroid chordoma versus low-grade chondrosarcoma of the base of the skull: can immunohistochemistry resolve the controversy? ( 7525890 )
1994
41
[Intracranial chordoma. Case report of a destructively growing chondroid chordoma in the area of the sella turcica]. ( 8237167 )
1993
42
Chondroid chordoma presenting with hypopituitarism. ( 1300173 )
1992
43
Delayed postcontrast CT and MR imaging of chondroid chordoma--case report. ( 1375982 )
1992
44
Classical and chondroid chordoma. A light-microscopic, histochemical, ultrastructural and immunohistochemical analysis of the various cell types. ( 1754509 )
1991
45
Chondroid chordoma: case report and literature review. ( 1997598 )
1991
46
Chondroid chordoma: a low-grade chondrosarcoma and its differential diagnosis. ( 2673669 )
1989
47
Primary chondroid chordoma of the base of the petrous temporal bone. ( 2769048 )
1989
48
Demonstration of cytokeratins and an epithelial membrane antigen in chondroid chordoma. ( 2444686 )
1987
49
Does chondroid chordoma exist? ( 2436434 )
1987
50
Chondroid chordoma of the sacrococcygeal region. ( 2443106 )
1987

Variations for Chondroid Chordoma

Expression for Chondroid Chordoma

Search GEO for disease gene expression data for Chondroid Chordoma.

Pathways for Chondroid Chordoma

GO Terms for Chondroid Chordoma

Cellular components related to Chondroid Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ACAN CDH1 CEACAM5 MFGE8 MUC1 S100A1
2 extracellular exosome GO:0070062 9.28 CDH1 CEACAM5 ENO2 EPCAM MFGE8 MUC1
3 extracellular vesicle GO:1903561 9.13 MFGE8 TUBB2A TUBB4B

Biological processes related to Chondroid Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule cytoskeleton organization GO:0000226 9.13 MAP2 TUBB2A TUBB4B
2 positive regulation of histone H4 acetylation GO:0090240 8.62 MUC1 SMARCB1

Molecular functions related to Chondroid Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 TUBB2A TUBB4B VIM

Sources for Chondroid Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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