MCID: CHN009
MIFTS: 33

Chondroid Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Chondroid Chordoma

MalaCards integrated aliases for Chondroid Chordoma:

Name: Chondroid Chordoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4152
NCIt 50 C6902
UMLS 73 C1266173

Summaries for Chondroid Chordoma

Disease Ontology : 12 A chordoma that histologically derives from chordoma, derives from chondroma, and derives from chondrosarcoma.

MalaCards based summary : Chondroid Chordoma is related to chordoma and clivus chondroid chordoma. An important gene associated with Chondroid Chordoma is VIM (Vimentin), and among its related pathways/superpathways are Development Slit-Robo signaling and Regulation of CFTR activity (norm and CF). Affiliated tissues include bone, pituitary and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chondroid Chordoma

Diseases related to Chondroid Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 chordoma 30.9 CDH1 CEACAM3 MUC1 S100A1 SMARCB1 VIM
2 clivus chondroid chordoma 12.8
3 hidradenoma 10.3 MUC1 VIM
4 malignant peritoneal mesothelioma 10.3 MUC1 VIM
5 parachordoma 10.3 MUC1 VIM
6 secretory meningioma 10.3 MUC1 VIM
7 syringocystadenoma papilliferum 10.3 MUC1 VIM
8 fibrous meningioma 10.3 MUC1 VIM
9 chordoid meningioma 10.3 MUC1 VIM
10 eccrine porocarcinoma 10.3 MUC1 VIM
11 endometrial mucinous adenocarcinoma 10.3 MUC1 VIM
12 bile duct adenoma 10.3 MUC1 VIM
13 adenofibroma 10.3 MUC1 VIM
14 clear cell meningioma 10.3 MUC1 VIM
15 myxopapillary ependymoma 10.3 MUC1 VIM
16 monophasic synovial sarcoma 10.3 MUC1 VIM
17 syringoma 10.3 MUC1 VIM
18 pleomorphic liposarcoma 10.3 MUC1 VIM
19 perivascular epithelioid cell tumor 10.2 MUC1 VIM
20 anaplastic ependymoma 10.2 MUC1 VIM
21 ischemic fasciitis 10.2 MUC1 S100A1
22 sertoli cell tumor 10.2 MUC1 VIM
23 mesenchymal chondrosarcoma 10.2 MUC1 VIM
24 chondrosarcoma 10.2
25 rhabdoid meningioma 10.2 SMARCB1 VIM
26 perineurioma 10.2 MUC1 VIM
27 reticulum cell sarcoma 10.2 MUC1 S100A1 VIM
28 cavernous hemangioma 10.2 MUC1 S100A1 VIM
29 odontoma 10.2 TUBB3 VIM
30 dermoid cyst 10.2 MUC1 VIM
31 apocrine adenoma 10.2 CEACAM5 MUC1
32 spindle cell sarcoma 10.2 MUC1 VIM
33 breast mucoepidermoid carcinoma 10.2 CEACAM5 MUC1
34 bile duct mucoepidermoid carcinoma 10.2 CEACAM5 MUC1
35 bile duct cystadenocarcinoma 10.2 CEACAM5 MUC1
36 anal paget's disease 10.2 CEACAM5 MFGE8
37 pilomatrix carcinoma 10.2 ENO2 MUC1
38 epulis 10.2 ENO2 VIM
39 intracranial cysts 10.2 ENO2 MUC1
40 anus adenocarcinoma 10.2 CEACAM5 MFGE8
41 rhabdoid tumor predisposition syndrome 1 10.2 MUC1 SMARCB1 VIM
42 epithelioid sarcoma 10.2 MUC1 SMARCB1 VIM
43 middle ear adenoma 10.1 ENO2 MUC1
44 bednar tumor 10.1 ENO2 VIM
45 primitive neuroectodermal tumor of the cervix uteri 10.1 ENO2 VIM
46 microcystic adenoma 10.1 ENO2 MUC1
47 myoepithelioma 10.1 S100A1 SMARCB1 VIM
48 malignant ectomesenchymoma 10.1 ENO2 S100A1
49 tubulin, beta 10.1 TUBB2A TUBB3 TUBB4B
50 epithelioid leiomyosarcoma 10.1 ENO2 VIM

Graphical network of the top 20 diseases related to Chondroid Chordoma:



Diseases related to Chondroid Chordoma

Symptoms & Phenotypes for Chondroid Chordoma

GenomeRNAi Phenotypes related to Chondroid Chordoma according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.77 SMARCB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.77 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.77 SMARCB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.77 MAP2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.77 SMARCB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.77 EPCAM
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.77 VIM
8 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.77 EPCAM
9 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.77 EPCAM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.77 EPCAM MAP2 SMARCB1 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.77 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.77 VIM
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.77 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.77 SMARCB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.77 EPCAM MAP2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.77 VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.77 VIM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.77 EPCAM VIM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.77 EPCAM
20 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 SMARCB1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 SMARCB1 VIM
22 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.77 EPCAM

Drugs & Therapeutics for Chondroid Chordoma

Search Clinical Trials , NIH Clinical Center for Chondroid Chordoma

Genetic Tests for Chondroid Chordoma

Anatomical Context for Chondroid Chordoma

MalaCards organs/tissues related to Chondroid Chordoma:

41
Bone, Pituitary, Kidney, Liver, Breast, Ovary, Pineal

Publications for Chondroid Chordoma

Articles related to Chondroid Chordoma:

(show top 50) (show all 59)
# Title Authors Year
1
Clival Chondroid Chordoma: A Case Report and Review of the Literature. ( 30519520 )
2018
2
A unique case of distant skin metastasis from chondroid chordoma. ( 27051831 )
2016
3
Chondroid chordoma of the sella turcica mimicking a pituitary adenoma. ( 26535833 )
2015
4
Skull base chondroid chordoma: atypical case manifesting as intratumoral hemorrhage and literature review. ( 25070287 )
2014
5
Chondroid chordoma in an atypical location. ( 23791243 )
2013
6
Chondroid chordoma and nasal adenocarcinoma: an exceptional association. ( 23024872 )
2012
7
Endoscopic management of a lower clival chondroid chordoma: case report. ( 22274986 )
2012
8
Cervical chondroid chordoma in a standard dachshund: a case report. ( 22017812 )
2011
9
Intrasellar chondroid chordoma: a case report. ( 22500242 )
2011
10
Endonasal endoscopic approach for the resection of chondroid chordoma with skull base involvement. ( 21959419 )
2011
11
Intradural suprasellar chondroid chordoma. ( 20074956 )
2010
12
Dumbbell-shaped thoracic chondroid chordoma mimicking a neurinoma. ( 19415177 )
2010
13
Chondroid chordoma of the skull base: immunohistochemical and ultrastructural study of two cases with special reference to microtubules within rough-surfaced endoplasmic reticulum. ( 21267702 )
2010
14
Adjuvant radiation therapy and chondroid chordoma subtype are associated with a lower tumor recurrence rate of cranial chordoma. ( 19953297 )
2010
15
A case of coccygeal chondroid chordoma in a cat: morphological and immunohistochemical features. ( 18776111 )
2008
16
Chondroid chordoma of petrous temporal bone with extensive recurrence and pulmonary metastases. ( 18688126 )
2008
17
Cervical chondroid chordoma in a Shetland sheep dog. ( 18374350 )
2008
18
Chondroid chordoma of the thoracic spine: case report. ( 17454766 )
2007
19
Craniospinal dissemination of clival chondroid chordoma. ( 16333198 )
2005
20
Chondroid chordoma of the L5 spinous process and lamina: a case report. ( 15895260 )
2005
21
Chondroid chordoma at the jugular foramen causing retrolabyrinthine lesions in both the cochlear and vestibular branches of the eighth cranial nerve. ( 14763580 )
2004
22
Chondroid chordoma of the nasal septum. ( 12578458 )
2003
23
Primary chondroid chordoma of the petrous part of the temporal bone. ( 14524492 )
2003
24
Chondroid chordoma of the cervical spine. ( 12382136 )
2002
25
Chondroid chordoma of the lateral skull base. ( 11244373 )
2001
26
Chondroid chordoma: fine-needle aspiration cytology with histopathological, immunohistochemical, and ultrastructural study of two cases. ( 10527481 )
1999
27
Drop metastases in a patient with a chondroid chordoma of the clivus. ( 10450844 )
1999
28
Hemorrhagic chondroid chordoma mimicking pituitary apoplexy. ( 9860121 )
1998
29
Intraoperative squash and touch cytology of chondroid chordoma of the skull base. Report of a case with immunocytochemical and immunohistochemical studies. ( 9167726 )
1997
30
Intracranial chondroid chordoma. ( 18638963 )
1997
31
Spheno-occipital chondroid chordoma. ( 9176805 )
1997
32
SELLAR CHONDROID CHORDOMA: A Case Report. ( 28769413 )
1996
33
Chondroid chordoma base of skull. ( 29542540 )
1996
34
Chondroid chordoma of the lateral skull base. ( 8751297 )
1995
35
Chondroid chordoma. ( 7572805 )
1995
36
Chondroid chordoma. A hyalinized chordoma without cartilaginous differentiation. ( 7532910 )
1995
37
Intracisternal microtubular aggregates in classic (non chondroid) chordoma. ( 7671211 )
1995
38
Chondroid chordoma--a variant of chordoma. A morphologic and immunohistochemical study. ( 7506477 )
1994
39
Chondroid chordoma versus low-grade chondrosarcoma of the base of the skull: can immunohistochemistry resolve the controversy? ( 7525890 )
1994
40
[Intracranial chordoma. Case report of a destructively growing chondroid chordoma in the area of the sella turcica]. ( 8237167 )
1993
41
Delayed postcontrast CT and MR imaging of chondroid chordoma--case report. ( 1375982 )
1992
42
Chondroid chordoma presenting with hypopituitarism. ( 1300173 )
1992
43
Chondroid chordoma: case report and literature review. ( 1997598 )
1991
44
Classical and chondroid chordoma. A light-microscopic, histochemical, ultrastructural and immunohistochemical analysis of the various cell types. ( 1754509 )
1991
45
Chondroid chordoma: a low-grade chondrosarcoma and its differential diagnosis. ( 2673669 )
1989
46
Primary chondroid chordoma of the base of the petrous temporal bone. ( 2769048 )
1989
47
Demonstration of cytokeratins and an epithelial membrane antigen in chondroid chordoma. ( 2444686 )
1987
48
Does chondroid chordoma exist? ( 2436434 )
1987
49
Chondroid chordoma. ( 3686707 )
1987
50
Isolated unilateral hypoglossal nerve palsy due to a chondroid chordoma. ( 3665173 )
1987

Variations for Chondroid Chordoma

Expression for Chondroid Chordoma

Search GEO for disease gene expression data for Chondroid Chordoma.

Pathways for Chondroid Chordoma

Pathways related to Chondroid Chordoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.2 CDH1 TUBB2A TUBB3 TUBB4B
2
Show member pathways
11.93 TUBB2A TUBB3 TUBB4B
3 11.88 TUBB2A TUBB3 TUBB4B
4 11.84 CDH1 EPCAM MUC1 TUBB3 VIM
5
Show member pathways
11.81 TUBB2A TUBB3 TUBB4B
6 11.76 CDH1 TUBB2A TUBB3
7
Show member pathways
11.7 TUBB2A TUBB3 TUBB4B
8 11.55 CDH1 CEACAM5 EPCAM MUC1
9 11.52 TUBB2A TUBB3 TUBB4B
10 11.44 TUBB2A TUBB3 TUBB4B
11 11.07 CDH1 TUBB2A TUBB3
12 11.02 ACAN CEACAM5 MUC1
13
Show member pathways
10.96 TUBB2A TUBB3 TUBB4B VIM
14 10.71 CDH1 VIM

GO Terms for Chondroid Chordoma

Cellular components related to Chondroid Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule GO:0005874 9.46 MAP2 TUBB2A TUBB3 TUBB4B
2 extracellular exosome GO:0070062 9.32 CDH1 CEACAM5 ENO2 EPCAM MFGE8 MUC1
3 extracellular vesicle GO:1903561 9.13 MFGE8 TUBB2A TUBB4B

Biological processes related to Chondroid Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitotic cell cycle GO:0000278 9.43 TUBB2A TUBB3 TUBB4B
2 positive regulation of histone H4 acetylation GO:0090240 9.16 MUC1 SMARCB1
3 microtubule-based process GO:0007017 9.13 TUBB2A TUBB3 TUBB4B
4 microtubule cytoskeleton organization GO:0000226 8.92 MAP2 TUBB2A TUBB3 TUBB4B

Molecular functions related to Chondroid Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.92 TUBB2A TUBB3 TUBB4B VIM

Sources for Chondroid Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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