MCID: CHN009
MIFTS: 32

Chondroid Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Chondroid Chordoma

MalaCards integrated aliases for Chondroid Chordoma:

Name: Chondroid Chordoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4152
NCIt 50 C6902
SNOMED-CT 68 128784007
UMLS 73 C1266173

Summaries for Chondroid Chordoma

Disease Ontology : 12 A chordoma that histologically derives from chordoma, derives from chondroma, and derives from chondrosarcoma.

MalaCards based summary : Chondroid Chordoma is related to chordoma and clivus chondroid chordoma. An important gene associated with Chondroid Chordoma is VIM (Vimentin), and among its related pathways/superpathways are Development Slit-Robo signaling and Cytoskeletal Signaling. Affiliated tissues include bone, pituitary and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chondroid Chordoma

Diseases related to Chondroid Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 chordoma 29.7 CDH1 CEACAM3 MUC1 S100A1 SMARCB1 VIM
2 clivus chondroid chordoma 12.6
3 malignant peritoneal mesothelioma 11.0 MUC1 VIM
4 parachordoma 10.9 MUC1 VIM
5 fibrous meningioma 10.9 MUC1 VIM
6 chordoid meningioma 10.9 MUC1 VIM
7 malignant mixed mullerian tumor 10.9 MUC1 VIM
8 syringocystadenoma papilliferum 10.9 MUC1 VIM
9 eccrine porocarcinoma 10.9 MUC1 VIM
10 endometrial mucinous adenocarcinoma 10.9 MUC1 VIM
11 adenofibroma 10.9 MUC1 VIM
12 myxopapillary ependymoma 10.9 MUC1 VIM
13 monophasic synovial sarcoma 10.9 MUC1 VIM
14 spiradenoma 10.9 MUC1 VIM
15 syringoma 10.9 MUC1 VIM
16 pleomorphic liposarcoma 10.8 MUC1 VIM
17 hidradenoma 10.8 MUC1 VIM
18 ischemic fasciitis 10.8 MUC1 S100A1
19 perivascular epithelioid cell tumor 10.8 MUC1 VIM
20 anaplastic ependymoma 10.8 MUC1 VIM
21 sertoli cell tumor 10.8 MUC1 VIM
22 mucinous cystadenocarcinoma 10.8 MUC1 VIM
23 mesenchymal chondrosarcoma 10.8 MUC1 VIM
24 rhabdoid meningioma 10.7 SMARCB1 VIM
25 reticulum cell sarcoma 10.7 MUC1 S100A1 VIM
26 perineurioma 10.7 MUC1 VIM
27 odontoma 10.7 TUBB3 VIM
28 breast mucoepidermoid carcinoma 10.6 CEACAM5 MUC1
29 apocrine adenoma 10.6 CEACAM5 MUC1
30 bile duct mucoepidermoid carcinoma 10.6 CEACAM5 MUC1
31 dermoid cyst 10.6 MUC1 VIM
32 bile duct cystadenocarcinoma 10.6 CEACAM5 MUC1
33 spindle cell sarcoma 10.6 MUC1 VIM
34 anal paget's disease 10.6 CEACAM5 MFGE8
35 pilomatrix carcinoma 10.5 ENO2 MUC1
36 intracranial cysts 10.5 ENO2 MUC1
37 anus adenocarcinoma 10.5 CEACAM5 MFGE8
38 rhabdoid cancer 10.5 MUC1 SMARCB1 VIM
39 epithelioid sarcoma 10.5 MUC1 SMARCB1 VIM
40 middle ear adenoma 10.5 ENO2 MUC1
41 microcystic adenoma 10.5 ENO2 MUC1
42 atypical teratoid rhabdoid tumor 10.5 MUC1 SMARCB1 VIM
43 bednar tumor 10.5 ENO2 VIM
44 primitive neuroectodermal tumor of the cervix uteri 10.5 ENO2 VIM
45 epulis 10.5 ENO2 VIM
46 malignant ectomesenchymoma 10.5 ENO2 S100A1
47 epithelioid leiomyosarcoma 10.5 ENO2 VIM
48 tubulin, beta 10.5 TUBB2A TUBB3 TUBB4B
49 myoepithelioma 10.5 S100A1 SMARCB1 VIM
50 exotropia 10.5 ACAN TUBB3

Graphical network of the top 20 diseases related to Chondroid Chordoma:



Diseases related to Chondroid Chordoma

Symptoms & Phenotypes for Chondroid Chordoma

GenomeRNAi Phenotypes related to Chondroid Chordoma according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.77 SMARCB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.77 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.77 SMARCB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.77 MAP2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.77 SMARCB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.77 EPCAM
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.77 VIM
8 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.77 EPCAM
9 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.77 EPCAM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.77 EPCAM MAP2 SMARCB1 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.77 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.77 VIM
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.77 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.77 SMARCB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.77 EPCAM MAP2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.77 VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.77 VIM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.77 EPCAM VIM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.77 EPCAM
20 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 SMARCB1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 SMARCB1 VIM
22 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.77 EPCAM

Drugs & Therapeutics for Chondroid Chordoma

Search Clinical Trials , NIH Clinical Center for Chondroid Chordoma

Genetic Tests for Chondroid Chordoma

Anatomical Context for Chondroid Chordoma

MalaCards organs/tissues related to Chondroid Chordoma:

41
Bone, Pituitary, Skin

Publications for Chondroid Chordoma

Articles related to Chondroid Chordoma:

(show top 50) (show all 59)
# Title Authors Year
1
A unique case of distant skin metastasis from chondroid chordoma. ( 27051831 )
2016
2
Chondroid chordoma of the sella turcica mimicking a pituitary adenoma. ( 26535833 )
2015
3
Skull Base Chondroid Chordoma: Atypical Case Manifesting as Intratumoral Hemorrhage and Literature Review. ( 25070287 )
2014
4
Chondroid chordoma in an atypical location. ( 23791243 )
2013
5
Chondroid chordoma and nasal adenocarcinoma: an exceptional association. ( 23024872 )
2012
6
Endoscopic management of a lower clival chondroid chordoma: case report. ( 22274986 )
2012
7
Cervical chondroid chordoma in a standard dachshund: a case report. ( 22017812 )
2011
8
Intrasellar chondroid chordoma: a case report. ( 22500242 )
2011
9
Endonasal endoscopic approach for the resection of chondroid chordoma with skull base involvement. ( 21959419 )
2011
10
Intradural suprasellar chondroid chordoma. ( 20074956 )
2010
11
Dumbbell-shaped thoracic chondroid chordoma mimicking a neurinoma. ( 19415177 )
2010
12
Chondroid chordoma of the skull base: immunohistochemical and ultrastructural study of two cases with special reference to microtubules within rough-surfaced endoplasmic reticulum. ( 21267702 )
2010
13
Adjuvant radiation therapy and chondroid chordoma subtype are associated with a lower tumor recurrence rate of cranial chordoma. ( 19953297 )
2010
14
A case of coccygeal chondroid chordoma in a cat: morphological and immunohistochemical features. ( 18776111 )
2008
15
Chondroid chordoma of petrous temporal bone with extensive recurrence and pulmonary metastases. ( 18688126 )
2008
16
Cervical chondroid chordoma in a Shetland sheep dog. ( 18374350 )
2008
17
Chondroid chordoma of the thoracic spine: case report. ( 17454766 )
2007
18
Craniospinal dissemination of clival chondroid chordoma. ( 16333198 )
2005
19
Chondroid chordoma of the L5 spinous process and lamina: a case report. ( 15895260 )
2005
20
Chondroid chordoma at the jugular foramen causing retrolabyrinthine lesions in both the cochlear and vestibular branches of the eighth cranial nerve. ( 14763580 )
2004
21
Chondroid chordoma of the nasal septum. ( 12578458 )
2003
22
Primary chondroid chordoma of the petrous part of the temporal bone. ( 14524492 )
2003
23
Chondroid chordoma of the cervical spine. ( 12382136 )
2002
24
Chondroid chordoma of the lateral skull base. ( 11244373 )
2001
25
Chondroid chordoma: fine-needle aspiration cytology with histopathological, immunohistochemical, and ultrastructural study of two cases. ( 10527481 )
1999
26
Drop metastases in a patient with a chondroid chordoma of the clivus. ( 10450844 )
1999
27
Hemorrhagic chondroid chordoma mimicking pituitary apoplexy. ( 9860121 )
1998
28
Intraoperative squash and touch cytology of chondroid chordoma of the skull base. Report of a case with immunocytochemical and immunohistochemical studies. ( 9167726 )
1997
29
Intracranial chondroid chordoma. ( 18638963 )
1997
30
Spheno-occipital chondroid chordoma. ( 9176805 )
1997
31
Chondroid chordoma of the lateral skull base. ( 8751297 )
1995
32
Chondroid chordoma. ( 7572805 )
1995
33
Chondroid chordoma. A hyalinized chordoma without cartilaginous differentiation. ( 7532910 )
1995
34
Intracisternal microtubular aggregates in classic (non chondroid) chordoma. ( 7671211 )
1995
35
Immunohistochemical and electron microscopic studies on intracranial chordomas: difference between typical chordomas and chondroid chordomas. ( 7512865 )
1994
36
Chondroid chordoma--a variant of chordoma. A morphologic and immunohistochemical study. ( 7506477 )
1994
37
Chondroid chordoma versus low-grade chondrosarcoma of the base of the skull: can immunohistochemistry resolve the controversy? ( 7525890 )
1994
38
[Intracranial chordoma. Case report of a destructively growing chondroid chordoma in the area of the sella turcica]. ( 8237167 )
1993
39
Chondroid chordomas and low-grade chondrosarcomas of the craniospinal axis. An immunohistochemical analysis of 17 cases. ( 1463093 )
1992
40
Delayed postcontrast CT and MR imaging of chondroid chordoma--case report. ( 1375982 )
1992
41
Chondroid chordoma presenting with hypopituitarism. ( 1300173 )
1992
42
Immunohistochemical distinction of classic and chondroid chordomas. ( 1722044 )
1991
43
Chondroid chordoma: case report and literature review. ( 1997598 )
1991
44
Classical and chondroid chordoma. A light-microscopic, histochemical, ultrastructural and immunohistochemical analysis of the various cell types. ( 1754509 )
1991
45
Chondroid chordoma: a low-grade chondrosarcoma and its differential diagnosis. ( 2673669 )
1989
46
Primary chondroid chordoma of the base of the petrous temporal bone. ( 2769048 )
1989
47
Demonstration of cytokeratins and an epithelial membrane antigen in chondroid chordoma. ( 2444686 )
1987
48
Does chondroid chordoma exist? ( 2436434 )
1987
49
Chondroid chordoma. ( 3686707 )
1987
50
Isolated unilateral hypoglossal nerve palsy due to a chondroid chordoma. ( 3665173 )
1987

Variations for Chondroid Chordoma

Expression for Chondroid Chordoma

Search GEO for disease gene expression data for Chondroid Chordoma.

Pathways for Chondroid Chordoma

Pathways related to Chondroid Chordoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.2 CDH1 TUBB2A TUBB3 TUBB4B
2 12.04 CDH1 EPCAM MUC1 TUBB3 VIM
3
Show member pathways
11.92 TUBB2A TUBB3 TUBB4B
4 11.87 TUBB2A TUBB3 TUBB4B
5
Show member pathways
11.81 TUBB2A TUBB3 TUBB4B
6
Show member pathways
11.7 TUBB2A TUBB3 TUBB4B
7 11.52 TUBB2A TUBB3 TUBB4B
8 11.44 TUBB2A TUBB3 TUBB4B
9 11.35 CDH1 CEACAM5 EPCAM MUC1
10 11.05 CDH1 TUBB2A TUBB3
11 11.02 ACAN CEACAM5 MUC1
12
Show member pathways
10.96 TUBB2A TUBB3 TUBB4B VIM
13 10.71 CDH1 VIM

GO Terms for Chondroid Chordoma

Cellular components related to Chondroid Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule GO:0005874 9.46 MAP2 TUBB2A TUBB3 TUBB4B
2 extracellular exosome GO:0070062 9.32 CDH1 CEACAM5 ENO2 EPCAM MFGE8 MUC1
3 extracellular vesicle GO:1903561 9.13 MFGE8 TUBB2A TUBB4B

Biological processes related to Chondroid Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitotic cell cycle GO:0000278 9.43 TUBB2A TUBB3 TUBB4B
2 positive regulation of histone H4 acetylation GO:0090240 9.16 MUC1 SMARCB1
3 microtubule-based process GO:0007017 9.13 TUBB2A TUBB3 TUBB4B
4 microtubule cytoskeleton organization GO:0000226 8.92 MAP2 TUBB2A TUBB3 TUBB4B

Molecular functions related to Chondroid Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.92 TUBB2A TUBB3 TUBB4B VIM

Sources for Chondroid Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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