MCID: CHN010
MIFTS: 43

Chondroma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Chondroma

MalaCards integrated aliases for Chondroma:

Name: Chondroma 12 73 20 54 44 15 70
Central Chondroma 12
Enchondroma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2602
MeSH 44 D002812
NCIt 50 C53459
SNOMED-CT 67 269638002
UMLS 70 C0936248 C1704356

Summaries for Chondroma

Disease Ontology : 12 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

MalaCards based summary : Chondroma, also known as central chondroma, is related to paragangliomas 1 and carney triad, and has symptoms including pain An important gene associated with Chondroma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Pathways in cancer and Mesodermal Commitment Pathway. Affiliated tissues include bone, tongue and thyroid, and related phenotypes are mortality/aging and growth/size/body region

Wikipedia : 73 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing... more...

Related Diseases for Chondroma

Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 281)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 31.3 SDHD SDHC SDHB SDHA
2 carney triad 30.9 SDHD SDHC SDHB SDHA PDGFRA KIT
3 rare tumor 30.7 KIT ACTC1
4 synovial chondromatosis 30.6 FN1 ACVR2A
5 fibroma 30.2 S100A1 NF1 CTNNB1 ACTC1
6 pleomorphic adenoma 30.1 S100A1 HMGA2 CTNNB1 ACTC1
7 chondromyxoid fibroma 30.0 S100A1 ACTC1
8 horner's syndrome 30.0 SDHD NF1
9 cranial nerve palsy 29.8 SDHD SDHB
10 glomus tumor 29.7 SDHD SDHB S100A1 ACTC1
11 cavernous hemangioma 29.6 S100A1 PDGFRA KIT
12 leiomyosarcoma 29.6 S100A1 PDGFRA NF1 KIT HMGA2 ACTC1
13 fibrosarcoma 29.5 PDGFRA KIT FN1 ACTC1
14 sarcoma, synovial 29.5 NF1 KIT HMGA2 CTNNB1
15 leiomyoma 29.4 S100A1 PDGFRA KIT HMGA2 ACTC1
16 mesenchymal cell neoplasm 29.4 PDGFRA KIT HMGA2 ANO1
17 lipomatosis, multiple 29.2 NF1 KIT HMGA2 ANO1
18 neurofibroma 29.0 S100A1 PDGFRA NF1 KIT ACTC1
19 paraganglioma 29.0 SDHD SDHC SDHB SDHAF2 SDHA NF1
20 neurilemmoma 28.8 S100A1 PDGFRA NF1 KIT ANO1 ACTC1
21 hereditary paraganglioma-pheochromocytoma syndromes 28.4 SDHD SDHC SDHB SDHAF2 SDHA NF1
22 gastric leiomyosarcoma 28.3 SDHD SDHC SDHB SDHAF2 SDHA PDGFRA
23 gastrointestinal stromal tumor 27.5 SDHD SDHC SDHB SDHA S100A1 PDGFRA
24 extraskeletal chondroma 11.5
25 juxtacortical chondroma 11.4
26 central nervous system chondroma 11.1
27 chondroid chordoma 10.9
28 phalanx chondroma 10.9
29 cartilage cancer 10.9
30 chondrosarcoma 10.6
31 holzgreve syndrome 10.4 FN1 CTNNB1
32 calcifying aponeurotic fibroma 10.4 FN1 ACTC1
33 nodular medulloblastoma 10.3 GLI1 CTNNB1
34 parachordoma 10.3 S100A1 ACTC1
35 sporadic pheochromocytoma/secreting paraganglioma 10.3 SDHD SDHB
36 plethora of newborn 10.3 SDHD SDHB
37 meningioma, familial 10.3
38 intracranial meningioma 10.3
39 secretory meningioma 10.3
40 lymphoplasmacyte-rich meningioma 10.3
41 nonsyndromic paraganglioma 10.3
42 glomangioma 10.3 S100A1 ACTC1
43 reticulum cell sarcoma 10.3 S100A1 ACTC1
44 osteochondroma 10.3
45 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.3
46 testicular gonadoblastoma 10.3 KIT CTNNB1
47 ossifying fibromyxoid tumor 10.3 S100A1 ACTC1
48 ectomesenchymoma 10.3 S100A1 HMGA2
49 ovarian fibrothecoma 10.3 KIT ACTC1
50 adult cystic nephroma 10.2 KIT ACTC1

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to Chondroma

Symptoms & Phenotypes for Chondroma

UMLS symptoms related to Chondroma:


pain

MGI Mouse Phenotypes related to Chondroma:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 10.33 ACTC1 ACVR2A ANO1 CTNNB1 EXT2 FN1
2 growth/size/body region MP:0005378 10.32 ACTC1 ACVR2A ANO1 CTNNB1 FN1 GLI1
3 cellular MP:0005384 10.3 ACTC1 ACVR2A CTNNB1 FN1 GLI1 KIT
4 homeostasis/metabolism MP:0005376 10.29 ACTC1 ACVR2A ANO1 CTNNB1 FN1 KIT
5 cardiovascular system MP:0005385 10.27 ACTC1 ACVR2A ANO1 CTNNB1 FN1 KIT
6 embryo MP:0005380 10.26 ACTC1 ACVR2A CTNNB1 EXT2 FN1 GLI1
7 craniofacial MP:0005382 10.2 ACTC1 ACVR2A CTNNB1 FN1 GLI1 KIT
8 hematopoietic system MP:0005397 10.19 ACTC1 ACVR2A CTNNB1 FN1 KIT NF1
9 nervous system MP:0003631 10.11 ACTC1 ACVR2A ANO1 CTNNB1 FN1 GLI1
10 muscle MP:0005369 10.09 ACTC1 ANO1 CTNNB1 FN1 KIT NF1
11 digestive/alimentary MP:0005381 10.08 ACVR2A ANO1 CTNNB1 GLI1 KIT NF1
12 neoplasm MP:0002006 10.06 CTNNB1 FN1 GLI1 KIT NF1 PDGFRA
13 normal MP:0002873 10.02 ACTC1 CTNNB1 FN1 GLI1 KIT NF1
14 renal/urinary system MP:0005367 9.7 ANO1 CTNNB1 GLI1 KIT NF1 PDGFRA
15 pigmentation MP:0001186 9.65 ACVR2A CTNNB1 KIT NF1 PDGFRA
16 respiratory system MP:0005388 9.56 ACVR2A ANO1 CTNNB1 GLI1 KIT NF1
17 skeleton MP:0005390 9.32 ACVR2A ANO1 CTNNB1 EXT2 FN1 KIT

Drugs & Therapeutics for Chondroma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase II, Placebo-controlled, Multicenter Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
2 Low Grade Chondrosarcoma Versus Enchondroma: Challenges in Diagnosis and Management Completed NCT02996747

Search NIH Clinical Center for Chondroma

Cochrane evidence based reviews: chondroma

Genetic Tests for Chondroma

Anatomical Context for Chondroma

MalaCards organs/tissues related to Chondroma:

40
Bone, Tongue, Thyroid, Pituitary, Brain, Myeloid, Small Intestine

Publications for Chondroma

Articles related to Chondroma:

(show top 50) (show all 2184)
# Title Authors PMID Year
1
Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. 54 61
14614053 2003
2
The changing face of central chondrosarcoma of bone. One UK-based orthopaedic oncology unit's experience of 33 years referrals. 61
33747783 2021
3
Chondrogenic Bone Tumors: The Importance of Imaging Characteristics. 61
33152784 2021
4
Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis. 61
33727696 2021
5
Early Surgical Treatment of Both Tumor and Fracture in Patients With Enchondroma of the Hand Combined With Pathologic Fracture. 61
33661226 2021
6
Acral FibroChondroMyxoid tumor: imaging features of a new entity. 61
32844242 2021
7
Curettage and cryosurgery for enchondroma and atypical cartilaginous tumors of the long bones: Oncological results of a large series. 61
33713465 2021
8
SDHC Methylation Pattern in Patients With Carney Triad. 61
33624983 2021
9
Enchondromatosis and Growth Plate Development. 61
33306166 2021
10
Chondrosarcoma. 61
33595238 2021
11
Carney triad: A case report, characteristics and literature review of this rare entity. 61
33422846 2021
12
Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis. 61
33500396 2021
13
MRI features of low-grade and high-grade chondrosarcoma in enchondromatosis. 61
33484272 2021
14
Chondroma of the Nasal Septum. 61
33527063 2021
15
Imaging Features of Primary Tumors of the Hand. 61
32811403 2021
16
Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital. 61
33181515 2021
17
Hand tumors: A review of 186 patients at a single institute. 61
33624536 2021
18
Solitary enchondroma in a metatarsal bone, an incidental discovery. 61
33373918 2021
19
MicroRNA-1236-3p inhibits human osteosarcoma growth. 61
33133267 2020
20
Mallet Finger Fracture through Enchondroma of the Distal Phalanx. 61
33408449 2020
21
Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery. 61
31091548 2020
22
Intracranial Dural-based Convexity Chondroma. 61
33342886 2020
23
Solitary long-bone epiphyseal lesions in children: radiologic-pathological correlation and epidemiology. 61
32638051 2020
24
Intraoperative frozen cytology of intraosseous cystic meningioma in the sphenoid bone. 61
32601263 2020
25
Solitary enchondromas-diagnosis and surveillance : Danish guidelines. 61
32322923 2020
26
Incidental long bone cartilage lesions: is any further imaging workup needed? 61
33169221 2020
27
Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma. 61
33266275 2020
28
Genomic Profiling of Low-grade Intramedullary Cartilage Tumors Can Distinguish Enchondroma From Chondrosarcoma. 61
33239505 2020
29
[Tumors affecting the temporomandibular joint - a literature review]. 61
33059872 2020
30
A painful lump on a teenager's toe is a benign enchondroma. 61
33220738 2020
31
Familial Giant Enchondroma of Thoracic Spine: A Rare Manifestation of a Rare Disease. 61
33342888 2020
32
Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus. 61
32882054 2020
33
Co-existence of lung carcinoma metastasis and enchondroma in the femur of a patient with Ollier disease. 61
33047157 2020
34
Magnetic Resonance Imaging Role in the Differentiation Between Atypical Cartilaginous Tumors and High-Grade Chondrosarcoma: An Updated Systematic Review. 61
33269165 2020
35
Extraskeletal chondroma. 61
33135912 2020
36
Chondroma in the Area of the Spheno-Ethmoid Junction. 61
32604309 2020
37
Novel Use of Ultrasonic Aspirator Device for Cricoid Chondroma Resection. 61
33107630 2020
38
The minimally invasive endoscopic technique for the treatment of symptomatic benign bone lesions: Preliminary results from a retrospective study. 61
32817813 2020
39
The distribution of chondromas: Why the hand? 61
32759011 2020
40
Carney-Stratakis Syndrome presenting as occult mediastinal paraganglioma. 61
32670454 2020
41
Periosteal Chondroma of the Radial Diaphysis-Rare Presentation and Review of Literature. 61
33364706 2020
42
An imaging protocol for the management of central cartilage tumours of the proximal fibula. 61
32665062 2020
43
Total Knee Arthroplasty and Atypical Cartilaginous Tumor/Enchondroma of the Distal Femur. 61
32743034 2020
44
Corrigendum to "Enchondroma protuberans of the hand: A case report" [Radiology Case Reports 15 (2020) 943-946]. 61
32774583 2020
45
Primary total shoulder arthroplasty in the setting of a benign enchondroma. 61
32815810 2020
46
Congenital laryngeal chondroma. 61
32811795 2020
47
Increased femoral anteversion related to infratrochanteric femoral torsion is associated with ACL rupture. 61
32030504 2020
48
Reconstruction of hand in aggressive benign bone tumors by mini JESS fixator. 61
32684713 2020
49
Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings. 61
30956151 2020
50
Enchondroma protuberans of the hand: A case report. 61
32405332 2020

Variations for Chondroma

Expression for Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for Chondroma

GO Terms for Chondroma

Cellular components related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
2 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.72 PDGFRA KIT GLI1 FN1 CTNNB1
2 wound healing GO:0042060 9.69 PDGFRA NF1 FN1
3 lung development GO:0030324 9.65 PDGFRA GLI1 CTNNB1
4 positive regulation of gene expression GO:0010628 9.65 KIT HMGA2 FN1 CTNNB1 ACTC1
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 PDGFRA KIT FN1
6 adrenal gland development GO:0030325 9.58 PDGFRA NF1
7 male genitalia development GO:0030539 9.57 PDGFRA CTNNB1
8 respiratory electron transport chain GO:0022904 9.56 SDHB SDHA
9 heart contraction GO:0060047 9.55 EXT2 ACTC1
10 regulation of osteoblast differentiation GO:0045667 9.54 GLI1 CTNNB1
11 electron transport chain GO:0022900 9.54 SDHC SDHB SDHA
12 gastrulation with mouth forming second GO:0001702 9.52 CTNNB1 ACVR2A
13 positive regulation of phospholipase C activity GO:0010863 9.49 PDGFRA KIT
14 cardiac myofibril assembly GO:0055003 9.43 PDGFRA ACTC1
15 negative regulation of oligodendrocyte differentiation GO:0048715 9.4 NF1 CTNNB1
16 tricarboxylic acid cycle GO:0006099 9.35 SDHD SDHC SDHB SDHAF2 SDHA
17 succinate metabolic process GO:0006105 9.16 SDHB SDHA
18 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 SDHD SDHC SDHAF2 SDHA

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.72 S100A1 PDGFRA KIT EXT2 ANO1
2 ubiquinone binding GO:0048039 9.26 SDHD SDHB
3 electron transfer activity GO:0009055 9.26 SDHD SDHC SDHB SDHA
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.16 SDHB SDHA
5 succinate dehydrogenase activity GO:0000104 8.8 SDHD SDHC SDHA

Sources for Chondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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