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MCID: CHN010
MIFTS: 45

Chondroma

Categories: Bone diseases, Cancer diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Chondroma

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MalaCards integrated aliases for Chondroma:

Name: Chondroma 12 77 54 56 45 15 74
Central Chondroma 12
Enchondroma 74

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2602
MeSH 45 D002812
NCIt 51 C53459
SNOMED-CT 69 31186001
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Summaries for Chondroma

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Disease Ontology : 12 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

MalaCards based summary : Chondroma, also known as central chondroma, is related to juxtacortical chondroma and carney triad, and has symptoms including pain An important gene associated with Chondroma is SDHC (Succinate Dehydrogenase Complex Subunit C), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. The drugs Cisplatin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include bone, tongue and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing... more...

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Related Diseases for Chondroma

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Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 juxtacortical chondroma 33.5 CTNNB1 HMGA2
2 carney triad 32.4 PDGFRA SDHB SDHC SDHD
3 paragangliomas 1 31.3 SDHB SDHC SDHD
4 leiomyosarcoma 30.6 ACTC1 PDGFRA
5 paraganglioma 30.2 SDHB SDHC SDHD
6 gastric leiomyosarcoma 30.1 PDGFRA SDHD
7 glomus tumor 29.5 ACTC1 SDHB SDHD
8 pleomorphic adenoma 29.5 ACTC1 HMGA2
9 paraganglioma and gastric stromal sarcoma 29.4 SDHB SDHC SDHD
10 gastrointestinal stromal tumor 28.7 ACTC1 PDGFRA SDHB SDHC SDHD
11 extraskeletal chondroma 12.5
12 central nervous system chondroma 12.1
13 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 12.1
14 phalanx chondroma 12.1
15 carpotarsal osteochondromatosis 11.2
16 cartilage cancer 11.1
17 chondroid chordoma 11.1
18 chondrosarcoma 10.4
19 nonsyndromic paraganglioma 10.3
20 fibromatosis 10.3 ACTC1 CTNNB1
21 nodular medulloblastoma 10.2 CTNNB1 GLI1
22 pseudosarcomatous fibromatosis 10.2 ACTC1 CTNNB1
23 polymorphous low-grade adenocarcinoma 10.2 ACTC1 CTNNB1
24 desmoid tumor 10.1 CTNNB1 PDGFRA
25 infratentorial cancer 10.1 CTNNB1 GLI1
26 osteochondroma 10.1
27 pulmonary vein stenosis 10.1 ACTC1 PDGFRA
28 carcinosarcoma 10.1 ACTC1 CTNNB1
29 asthma 10.1
30 fibroma 10.1
31 chondroblastoma 10.1
32 enchondroma 10.1
33 multiple endocrine neoplasia 10.0 SDHB SDHC
34 carpal tunnel syndrome 10.0
35 chordoma 10.0
36 osteoid osteoma 10.0
37 meningioma, familial 10.0
38 mononeuropathy of the median nerve, mild 10.0
39 spinal meningioma 10.0
40 hyperostosis 10.0
41 radiculopathy 10.0
42 secretory meningioma 10.0
43 epithelioid leiomyosarcoma 10.0
44 adenoma 10.0
45 neuropathy 10.0
46 hard palate cancer 10.0
47 dermatofibrosarcoma protuberans 9.9 ACTC1 PDGFRA
48 dedifferentiated liposarcoma 9.9 ACTC1 HMGA2
49 multiple endocrine neoplasia, type iia 9.9 SDHB SDHD
50 smooth muscle tumor 9.9 ACTC1 HMGA2

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to Chondroma
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Symptoms & Phenotypes for Chondroma

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UMLS symptoms related to Chondroma:


pain

GenomeRNAi Phenotypes related to Chondroma according to GeneCards Suite gene sharing:

27 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.5 CTNNB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.5 CTNNB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.5 SDHC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.5 CTNNB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.5 SDHC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.5 CTNNB1 SDHC
7 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.5 CTNNB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.5 CTNNB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.5 SDHC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.5 CTNNB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.5 CTNNB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.5 CTNNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.5 CTNNB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.5 SDHC

MGI Mouse Phenotypes related to Chondroma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.7 ACTC1 CTNNB1 GLI1 PDGFRA SDHB SDHC
2 endocrine/exocrine gland MP:0005379 9.65 CTNNB1 GLI1 PDGFRA SDHB SDHD
3 neoplasm MP:0002006 9.35 CTNNB1 GLI1 PDGFRA SDHB SDHD
4 normal MP:0002873 9.1 ACTC1 CTNNB1 GLI1 PDGFRA SDHB SDHD
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Drugs & Therapeutics for Chondroma

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Drugs for Chondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved 15663-27-1 2767 441203 84093
2
Methotrexate Approved 1959-05-2, 59-05-2 126941
3
Doxorubicin Approved, Investigational 23214-92-8 31703
4
Doxil Approved June 1999 31703

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
2 Low Grade Chondrosarcoma Versus Enchondroma Completed NCT02996747
3 Proteomics Research of Osteosarcoma Recruiting NCT03932058 Chemotherapy

Search NIH Clinical Center for Chondroma

Cochrane evidence based reviews: chondroma

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Genetic Tests for Chondroma

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Anatomical Context for Chondroma

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MalaCards organs/tissues related to Chondroma:

42
Bone, Tongue, Lung, Brain, Spinal Cord, Breast, Trachea
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Publications for Chondroma

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Articles related to Chondroma:

(show top 50) (show all 616)
# Title Authors Year
1
Intracranial Dural Parafalcine Chondroma: Case Report and Systematic Review of the Literature. ( 30273721 )
2019
2
Rare case of bladder chondroma causing lower urinary tract symptoms. ( 30661043 )
2019
3
Transsphenoidal Removal of Retroclival Chondroma with Pituitary Transposition Manifesting as Repeated Subarachnoid Hemorrhage: A Case Report. ( 30708387 )
2019
4
Chondroma of the Tongue. ( 30845089 )
2019
5
Chondroma of laryngeal cartilage mimicking thyroid tumor: A case report. ( 30921219 )
2019
6
Juxta-Cortical Chondroma of the Phalanges: Is there a Role for Cone-Beam Computed Tomography in Diagnosis and Local Staging?: Main teaching point: Low-dose cone-beam computed tomography (CT) may be of additional value to radiographs and magnetic resonance imaging (MRI) in preoperative characterization and local staging of juxta-cortical chondroma. ( 30972379 )
2019
7
An Intraventricular Type of Chondroma : A Case Report. ( 30984997 )
2019
8
Parotid gland chondroma masquerading as pleomorphic adenoma in fine needle aspiration cytology: A diagnostic challenge. ( 30144346 )
2018
9
Intracranial dural chondroma in a child-conventional and advanced neuroimaging characteristics and differential diagnosis. ( 28631961 )
2018
10
Soft tissue chondroma on the lip: Clinical, histopathological and ultrasonographic findings. ( 29115679 )
2018
11
Soft-Tissue Chondroma in the Preauricular Region: An Unusual Presentation. ( 29387304 )
2018
12
Periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism. ( 29413778 )
2018
13
Cervical Periosteal Chondroma Causing Spinal Cord or Nerve Compression: 2 Case Reports and Literature Review. ( 29550598 )
2018
14
Massive Intradural Chondroma Masquerading as Lower Body Parkinsonism. ( 29581912 )
2018
15
Giant convexity chondroma with meningeal attachment. ( 29609117 )
2018
16
Soft-Tissue Chondroma of Anterior Gingiva: A Rare Entity. ( 29725547 )
2018
17
Intracranial chondroma without meningeal attachment. ( 29766963 )
2018
18
Extraskeletal chondroma walling the temporomandibular joint: Report of a rare case and review of the literature. ( 29966951 )
2018
19
Soft-tissue chondroma within the extensor tendon of the index finger in a child. ( 30033358 )
2018
20
Giant extraskeletal chondroma of the hand: A rare case. ( 30037203 )
2018
21
Soft Tissue Chondroma of the Eyelid. ( 30124612 )
2018
22
Breast chondroma. ( 30264439 )
2018
23
Primary chondroma of posterior mediastinum with Horner's syndrome: a case report. ( 30333040 )
2018
24
Two Cases of Cartilaginous Choristoma-Not Chondroma of the Bony External Auditory Canal. ( 30652042 )
2018
25
Computed Tomography Imaging Findings of Pulmonary Chondroma. ( 30687744 )
2018
26
A case of chondroma cutis showing callus-like appearance. ( 26932734 )
2017
27
Intradural chondroma in the cervical spine: case report. ( 27740393 )
2017
28
Breast Chondroma. ( 27797122 )
2017
29
Trigger Finger Caused by Extraskeletal Chondroma. ( 27817941 )
2017
30
Synovial chondroma in Hoffa's fat pad: Case report and literature review of a rare disorder. ( 28130075 )
2017
31
Chondroma of the Bladder: A Case Report and Review of the Literature. ( 28479478 )
2017
32
Giant convexity chondroma with dural involvement: Case report and review of literature. ( 28484562 )
2017
33
Chondroma of the Sternum Growing in a Pregnant Patient: A Case Report. ( 28592723 )
2017
34
Extraskeletal Chondroma of the Index Finger: A Case Report. ( 28690520 )
2017
35
Para-articular extraskeletal chondroma mimicking first metatarsophalangeal synovitis. ( 28828128 )
2017
36
Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice. ( 29106539 )
2017
37
Chondroma of the Bladder: An Atypical Localization. ( 29138708 )
2017
38
Extraskeletal Chondroma with Concomitant Arthrosis of the Foot at the First Metatarsophalangeal Joint A Case Report. ( 29252024 )
2017
39
Is PET-CT an accurate method for the differential diagnosis between chondroma and chondrosarcoma? ( 27026930 )
2016
40
Scrotal chondroma in a young male: A rare case report. ( 27166053 )
2016
41
Periosteal chondroma with spinal cord compression in the thoracic spinal canal: a case report. ( 27179652 )
2016
42
Malignant transformation of a tracheal chondroma: The second reported case and review of the literature. ( 27185409 )
2016
43
Laryngeal Chondroma: An Unusual Complication Endotracheal Entubation. ( 27213734 )
2016
44
Chondroma arising from the spinal dura mater at the thoracic level: A case report with molecular analysis. ( 27461824 )
2016
45
Case report of chondroma in a grass carp (Ctenopharyngodon idella). ( 27482364 )
2016
46
Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature. ( 27602219 )
2016
47
Endobronchial chondroma: An unusual case of bronchial obstruction. ( 25770939 )
2016
48
Bilateral extraskeletal chondroma of the neck. ( 26381679 )
2016
49
Intracranial dural based chondroma. ( 26602798 )
2016
50
Giant Dural Supratentorial Chondroma Generating the Question of How Large Can a Tumor Become Without Revealing Itself. ( 26918096 )
2015
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Variations for Chondroma

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Expression for Chondroma

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Search GEO for disease gene expression data for Chondroma.
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Pathways for Chondroma

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Pathways related to Chondroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Carbon metabolism 38
Show member pathways
 11.66 SDHB SDHC SDHD
2
Pyruvate metabolism and Citric Acid (TCA) cycle 67
Show member pathways
 11.25 SDHB SDHC SDHD
3
Cardiac Progenitor Differentiation 1
11.05 ACTC1 PDGFRA
4
Cell adhesion_Cadherin-mediated cell adhesion 23
10.86 ACTC1 CTNNB1
5
Citrate cycle (TCA cycle) 38
Show member pathways
 10.81 SDHB SDHC SDHD
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GO Terms for Chondroma

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Cellular components related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-DNA complex GO:0032993 9.16 CTNNB1 HMGA2
2 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.71 ACTC1 CTNNB1 HMGA2
2 negative regulation of apoptotic process GO:0043066 9.58 ACTC1 CTNNB1 HMGA2
3 canonical Wnt signaling pathway GO:0060070 9.52 CTNNB1 GLI1
4 odontogenesis of dentin-containing tooth GO:0042475 9.51 CTNNB1 PDGFRA
5 dorsal/ventral pattern formation GO:0009953 9.49 CTNNB1 GLI1
6 epithelial to mesenchymal transition GO:0001837 9.48 CTNNB1 HMGA2
7 aerobic respiration GO:0009060 9.46 SDHB SDHC
8 proximal/distal pattern formation GO:0009954 9.43 CTNNB1 GLI1
9 cardiac myofibril assembly GO:0055003 9.37 ACTC1 PDGFRA
10 lung development GO:0030324 9.33 CTNNB1 GLI1 PDGFRA
11 male genitalia development GO:0030539 9.32 CTNNB1 PDGFRA
12 regulation of osteoblast differentiation GO:0045667 9.26 CTNNB1 GLI1
13 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.96 SDHC SDHD
14 tricarboxylic acid cycle GO:0006099 8.8 SDHB SDHC SDHD

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
2 SMAD binding GO:0046332 9.26 CTNNB1 HMGA2
3 ubiquinone binding GO:0048039 8.96 SDHB SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.8 SDHB SDHC SDHD
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Sources for Chondroma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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