MCID: CHN010
MIFTS: 43

Chondroma

Categories: Bone diseases, Cancer diseases, Rare diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Chondroma

MalaCards integrated aliases for Chondroma:

Name: Chondroma 11 19 75 53 43 14 71 75
Central Chondroma 11
Enchondroma 71

Classifications:



External Ids:

Disease Ontology 11 DOID:2602
MeSH 43 D002812
NCIt 49 C53459
SNOMED-CT 68 269638002
UMLS 71 C0936248 C1704356

Summaries for Chondroma

GARD: 19 A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)

MalaCards based summary: Chondroma, also known as central chondroma, is related to soft tissue chondroma and carney triad, and has symptoms including pain An important gene associated with Chondroma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Disease and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Affiliated tissues include bone, tongue and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Decreased viability in pancreas lineage

Disease Ontology: 11 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Wikipedia: 75 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing... more...

Related Diseases for Chondroma

Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 383)
# Related Disease Score Top Affiliating Genes
1 soft tissue chondroma 32.5 HMGA2 ACVR2A
2 carney triad 31.5 SDHD SDHC SDHB SDHA PDGFRA KIT
3 paragangliomas 1 31.5 SDHD SDHC SDHB SDHA
4 juxtacortical chondroma 31.5 IDH2 IDH1 EXT2
5 chondroblastoma 30.5 S100A1 CTNNB1 ANO1
6 epithelioid leiomyosarcoma 30.4 KIT ANO1 ACTC1
7 enchondroma 30.3 IDH2 IDH1
8 fibroma 30.2 S100A1 NF1 FN1 CTNNB1 ACTC1
9 leiomyoma 30.0 S100A1 KIT HMGA2 ACTC1
10 pleomorphic adenoma 30.0 S100A1 HMGA2 FN1 CTNNB1 ACTC1
11 horner's syndrome 30.0 SDHD SDHB NF1
12 leiomyosarcoma 29.9 S100A1 PDGFRA NF1 KIT HMGA2 ACTC1
13 chondrosarcoma 29.9 S100A1 PDGFRA IDH2 IDH1 EXT2
14 meningioma, familial 29.9 NF1 KIT IDH1 GLI1 CTNNB1
15 sarcoma 29.8 S100A1 PDGFRA KIT GLI1 CTNNB1 ACTC1
16 sarcoma, synovial 29.7 NF1 KIT HMGA2 CTNNB1
17 enchondromatosis, multiple, ollier type 29.7 IDH2 IDH1 EXT2
18 fibrosarcoma 29.7 PDGFRA KIT FN1 ACTC1
19 chordoma 29.6 S100A1 PDGFRA IDH2 IDH1 CTNNB1
20 lipomatosis, multiple 29.5 S100A1 NF1 KIT HMGA2 ANO1
21 hemangioma 29.5 KIT IDH1 CTNNB1 ACTC1
22 intracranial chondrosarcoma 29.5 IDH2 IDH1
23 connective tissue benign neoplasm 29.4 NF1 KIT CTNNB1 ANO1
24 mesenchymal cell neoplasm 29.4 PDGFRA NF1 KIT HMGA2 CTNNB1 ANO1
25 gastrointestinal stromal tumor 29.4 SDHD SDHC SDHB SDHAF2 SDHA S100A1
26 periosteal chondrosarcoma 29.4 IDH2 IDH1 EXT2
27 gastric leiomyosarcoma 29.3 SDHD SDHC SDHB SDHA PDGFRA KIT
28 neurofibroma 29.3 S100A1 PDGFRA NF1 KIT ACTC1
29 paraganglioma 29.2 SDHD SDHC SDHB SDHAF2 SDHA NF1
30 neurilemmoma 29.2 S100A1 PDGFRA NF1 KIT ANO1 ACTC1
31 hereditary paraganglioma-pheochromocytoma syndromes 28.9 SDHD SDHC SDHB SDHAF2 SDHA NF1
32 spinal cord disease 28.9 PDGFRA NF1 IDH2 IDH1
33 glomus tumor 28.8 SDHD SDHB S100A1 NF1 KIT ANO1
34 central nervous system chondroma 11.1
35 chondroid chordoma 11.0
36 phalanx chondroma 11.0
37 cartilage cancer 10.9
38 cervicofacial fibrochondroma 10.9
39 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 10.5
40 sporadic pheochromocytoma/secreting paraganglioma 10.3 SDHD SDHB
41 paragangliomas 4 10.3 SDHD SDHB
42 osteochondroma 10.3
43 carotid body cancer 10.3 SDHD SDHB
44 scrotum melanoma 10.3 SDHD SDHA
45 cowden syndrome 4 10.3 SDHC SDHB
46 rare tumor 10.3
47 trachea leiomyoma 10.3 S100A1 GLI1
48 eosinophilic variant of chromophobe renal cell carcinoma 10.2 S100A1 KIT
49 cartilage disease 10.2
50 mitochondrial complex ii deficiency, nuclear type 1 10.2 SDHD SDHA

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to Chondroma

Symptoms & Phenotypes for Chondroma

UMLS symptoms related to Chondroma:


pain

GenomeRNAi Phenotypes related to Chondroma according to GeneCards Suite gene sharing:

25 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ACTC1 ACVR2A ANO1 CTNNB1 EXT2 FN1
2 no effect GR00402-S-2 10.18 ACTC1 ACVR2A ANO1 CTNNB1 FN1 GLI1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-112 10.07 IDH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.07 IDH1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-129 10.07 PDGFRA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-136 10.07 IDH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.07 IDH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.07 PDGFRA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.07 KIT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.07 KIT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-167 10.07 PDGFRA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.07 KIT
13 Increased shRNA abundance (Z-score > 2) GR00366-A-172 10.07 IDH1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-18 10.07 IDH1 PDGFRA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-204 10.07 PDGFRA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-207 10.07 PDGFRA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.07 KIT
18 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.07 PDGFRA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-39 10.07 IDH1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.07 CTNNB1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.07 PDGFRA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-61 10.07 KIT
23 Increased shRNA abundance (Z-score > 2) GR00366-A-77 10.07 PDGFRA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.07 KIT
25 Increased shRNA abundance (Z-score > 2) GR00366-A-86 10.07 PDGFRA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.07 KIT
27 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.07 KIT
28 Decreased viability in pancreas lineage GR00235-A 9.16 GLI1 IDH1

MGI Mouse Phenotypes related to Chondroma:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ACTC1 ACVR2A ANO1 CTNNB1 FN1 HMGA2
2 nervous system MP:0003631 10.37 ACTC1 ACVR2A ANO1 CTNNB1 FN1 GLI1
3 growth/size/body region MP:0005378 10.37 ACTC1 ACVR2A ANO1 CTNNB1 FN1 GLI1
4 neoplasm MP:0002006 10.32 CTNNB1 FN1 GLI1 HMGA2 IDH2 KIT
5 normal MP:0002873 10.27 ACTC1 CTNNB1 FN1 GLI1 KIT NF1
6 cellular MP:0005384 10.25 ACTC1 ACVR2A CTNNB1 FN1 GLI1 HMGA2
7 muscle MP:0005369 10.19 ACTC1 ANO1 CTNNB1 FN1 KIT NF1
8 embryo MP:0005380 10.18 ACVR2A CTNNB1 EXT2 FN1 GLI1 KIT
9 renal/urinary system MP:0005367 10.15 ANO1 CTNNB1 GLI1 HMGA2 KIT NF1
10 behavior/neurological MP:0005386 10.13 ACTC1 ANO1 CTNNB1 GLI1 HMGA2 KIT
11 cardiovascular system MP:0005385 10.11 ACTC1 ACVR2A ANO1 CTNNB1 FN1 IDH2
12 craniofacial MP:0005382 10.09 ACVR2A CTNNB1 FN1 GLI1 HMGA2 KIT
13 limbs/digits/tail MP:0005371 10.07 CTNNB1 FN1 GLI1 HMGA2 KIT NF1
14 digestive/alimentary MP:0005381 10.06 ACVR2A ANO1 CTNNB1 GLI1 HMGA2 KIT
15 skeleton MP:0005390 10 ACVR2A ANO1 CTNNB1 EXT2 FN1 GLI1
16 pigmentation MP:0001186 9.98 ACVR2A CTNNB1 KIT NF1 PDGFRA
17 respiratory system MP:0005388 9.91 ACVR2A ANO1 CTNNB1 GLI1 IDH1 KIT
18 hematopoietic system MP:0005397 9.73 ACTC1 ACVR2A CTNNB1 FN1 IDH1 IDH2
19 mortality/aging MP:0010768 9.55 ACTC1 ACVR2A ANO1 CTNNB1 EXT2 FN1

Drugs & Therapeutics for Chondroma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase II, Placebo-controlled, Multicenter Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
2 Low Grade Chondrosarcoma Versus Enchondroma: Challenges in Diagnosis and Management Completed NCT02996747

Search NIH Clinical Center for Chondroma

Cochrane evidence based reviews: chondroma

Genetic Tests for Chondroma

Anatomical Context for Chondroma

Organs/tissues related to Chondroma:

MalaCards : Bone, Tongue, Spinal Cord, Lung, Trachea, Occipital Lobe, Thyroid

Publications for Chondroma

Articles related to Chondroma:

(show top 50) (show all 1587)
# Title Authors PMID Year
1
Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. 53 62
14614053 2003
2
Rapidly growing proliferative pulmonary chondroma: A case report. 62
36434873 2022
3
Hondrosarcoma of the chest with intraabdominal distribution (case report). 62
36099459 2022
4
Extraskeletal Osteochondroma in the Posterior Neck of a Middle-Aged Female: A Case Report. 62
36276210 2022
5
Unusual chondroblastoma of the hand with large extraosseous soft tissue component. 62
35814820 2022
6
Differentiation of Skull Base Chondrosarcomas, Chordomas, and Metastases: Utility of DWI and Dynamic Contrast-Enhanced Perfusion MR Imaging. 62
35953276 2022
7
Periosteal chondroma of the rib: A case report. 62
36159509 2022
8
[Skin chondroma of neck in children: report of a case]. 62
35673737 2022
9
About a misleading calcified mass of the elbow: Soft tissue osteochondroma: A case report. 62
35662034 2022
10
Imaging characteristics of slow-growing soft tissue chondroma of the tongue: A case report. 62
35583538 2022
11
Chondroma of the urinary bladder: A case report. 62
35608424 2022
12
Endobronchial Chondroma: A Rare Case of Benign Tumor With Atypical High Standardized Uptake Value. 62
35686284 2022
13
[Soft tissue tumours with FN1 (Fibronectin 1) fusion gene]. 62
35181149 2022
14
Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) of the Foot: A Case Report and Literature Review of Nora's Lesion of the Foot. 62
35602798 2022
15
Intraspinal periosteal chondroma in upper thoracic spine causing cord compression and myelopathy: A case report. 62
35378407 2022
16
Arthroscopic surgery for synovial chondroma of the subacromial bursa with non-traumatic shoulder subluxation complications: Two case reports. 62
35211605 2022
17
[Soft tissue chondroma of the liver: report of a case]. 62
35152637 2022
18
Thorahcic SMARCA4-deficient undifferentiated tumors with ganglioneuroma and enchondroma: implications for SLC7A11 and ARID1A expression: a case report. 62
35151345 2022
19
Histopathological pattern of primary bone tumours at the Black Lion Specialized Hospital, Addis Ababa, Ethiopia: a retrospective cross-sectional, 2015-2019. 62
35371378 2022
20
Clinical and Imaging Features of Tumors in the Scapula. 62
34488589 2022
21
Imaging Diagnosis of Primary Solitary Bone Neoplasts and Its Comparison with Tumor-like Lesions. 62
35990818 2022
22
Soft Tissue Chondroma: A Possible Diagnosis of Single-Digit Nail Clubbing. 62
34904580 2022
23
Soft tissue chondroma of the plantar foot in a 14-year-old boy: a case report. 62
34959092 2022
24
Dural Convexity Chondroma Mimicking Meningioma in a Young Female. 62
35106249 2021
25
Carney's triad in an adult male from a tertiary care center in India: a case report. 62
34782012 2021
26
Chondroblastoma-Like Soft-Tissue Chondroma of the Hand: A Case Report. 62
34912609 2021
27
[Orbital chondroma (about a case)]. 62
34544595 2021
28
Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling. 62
34423857 2021
29
Primary soft tissue chondroma of the posterior mediastinum: a rare case report and literature review. 62
34686095 2021
30
RCAN1.4 suppresses the osteosarcoma growth and metastasis via interfering with the calcineurin/NFAT signaling pathway. 62
34336566 2021
31
SDHC Methylation Pattern in Patients With Carney Triad. 62
33624983 2021
32
Low-grade chondrosarcoma of the larynx: A case report. 62
34621830 2021
33
Novel Use of Ultrasonic Aspirator Device for Cricoid Chondroma Resection. 62
33107630 2021
34
Periosteal Chondroma of the Pelvis: An Uncommon Tumor in an Unusual Location. 62
34548974 2021
35
Unusual Anterior Mediastinal Tumors Treated at a Tertiary Thoracic Center: A Case Series Analysis. 62
34646675 2021
36
The Application of Arthroscopic Techniques in the Diagnosis and Treatment of Hip-Related Conditions in China. 62
34351067 2021
37
"Slipped capital femoral epiphysis in a 25-year-old hypogonadic man with a large cranial chondroma: causality or coincidence? ". 62
34404399 2021
38
Pelvic chodroma in the left obturator foramen: The first case report. 62
34388900 2021
39
Extra-articular tenosynovial chondromatosis of the right fifth digit in a 59-year-old man: A case report and literature review. 62
35586796 2021
40
Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis. 62
33727696 2021
41
Resection of Huge Nasal Septal Chondroma Via Endoscopic Septoplasty Approach Through Modified Killian Incision. 62
34130516 2021
42
Congenital laryngeal chondroma. 62
32811795 2021
43
Intracortical chondroma of the metacarpal bone: A case report. 62
33969092 2021
44
[CT and Magnetic Resonance Imaging Findings of the Intracranial Extra-cerebral Chondroma:A Case Report]. 62
33966714 2021
45
Acral FibroChondroMyxoid tumor: imaging features of a new entity. 62
32844242 2021
46
A case of Carney triad complicated by renal cell carcinoma and a germline SDHA pathogenic variant. 62
33839693 2021
47
Carney triad: A case report, characteristics and literature review of this rare entity. 62
33422846 2021
48
Falcine chondroma: illustrative case. 62
36045938 2021
49
Case report: Rare convexity meningeal chondroma mimicking a meningioma. 62
34513189 2021
50
Hand tumors: A review of 186 patients at a single institute. 62
33624536 2021

Variations for Chondroma

Expression for Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for Chondroma

Pathways related to Chondroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 S100A1 PDGFRA NF1 KIT IDH1 FN1
2
Show member pathways
12.59 SDHD SDHC SDHB SDHA IDH2
3 12.27 SDHAF2 SDHA IDH2 IDH1
4 12.27 PDGFRA KIT FN1 CTNNB1 ACTC1
5
Show member pathways
12 SDHA SDHB SDHC SDHD
6
Show member pathways
11.59 PDGFRA KIT CTNNB1
7
Show member pathways
11.59 SDHD SDHC SDHB SDHA IDH2
8
Show member pathways
11.38 SDHD SDHC SDHB SDHA IDH2 IDH1
9 11.22 PDGFRA KIT ACTC1
10
Show member pathways
10.1 SDHD SDHC SDHB SDHAF2 SDHA

GO Terms for Chondroma

Cellular components related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 9.23 SDHD SDHC SDHB SDHA

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 odontogenesis of dentin-containing tooth GO:0042475 9.93 PDGFRA CTNNB1 ACVR2A
2 chondrocyte differentiation GO:0002062 9.91 HMGA2 EXT2 CTNNB1
3 proton motive force-driven mitochondrial ATP synthesis GO:0042776 9.76 SDHA SDHB SDHC SDHD
4 isocitrate metabolic process GO:0006102 9.71 IDH2 IDH1
5 succinate metabolic process GO:0006105 9.67 SDHB SDHA
6 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.65 SDHD SDHC SDHB SDHAF2 SDHA
7 mast cell proliferation GO:0070662 9.62 NF1 KIT
8 glyoxylate cycle GO:0006097 9.56 IDH2 IDH1
9 tricarboxylic acid cycle GO:0006099 9.47 SDHD SDHC SDHB SDHAF2 SDHA IDH2

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquinone binding GO:0048039 9.62 SDHD SDHB
2 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.56 IDH2 IDH1
3 electron transfer activity GO:0009055 9.56 SDHD SDHC SDHB SDHA
4 succinate dehydrogenase activity GO:0000104 9.46 SDHC SDHA
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.1 SDHD SDHB SDHA

Sources for Chondroma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....