MCID: CHN010
MIFTS: 44

Chondroma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Chondroma

MalaCards integrated aliases for Chondroma:

Name: Chondroma 12 76 53 55 44 15 73
Central Chondroma 12
Enchondroma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2602
MeSH 44 D002812
NCIt 50 C53459
SNOMED-CT 68 31186001

Summaries for Chondroma

Disease Ontology : 12 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

MalaCards based summary : Chondroma, also known as central chondroma, is related to juxtacortical chondroma and carney triad, and has symptoms including pain An important gene associated with Chondroma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include bone, tongue and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing... more...

Related Diseases for Chondroma

Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 juxtacortical chondroma 33.1 CTNNB1 HMGA2 PTH1R
2 carney triad 32.9 SDHB SDHC SDHD
3 paragangliomas 1 31.4 SDHB SDHC SDHD
4 paraganglioma 30.3 SDHB SDHC SDHD
5 chondromyxoid fibroma 29.8 ACTC1 PTH1R
6 glomus tumor 29.6 ACTC1 SDHB SDHD
7 pleomorphic adenoma 29.5 ACTC1 HMGA2
8 gastrointestinal stromal tumor 29.3 ACTC1 SDHB SDHC SDHD
9 extraskeletal chondroma 12.5
10 central nervous system chondroma 12.1
11 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 12.0
12 phalanx chondroma 12.0
13 carpotarsal osteochondromatosis 11.2
14 chondroid chordoma 11.1
15 chondrosarcoma 10.4
16 nonsyndromic paraganglioma 10.3
17 leiomyosarcoma 10.3
18 fibromatosis 10.2 ACTC1 CTNNB1
19 pseudosarcomatous fibromatosis 10.1 ACTC1 CTNNB1
20 nodular medulloblastoma 10.1 CTNNB1 GLI1
21 osteochondroma 10.1
22 polymorphous low-grade adenocarcinoma 10.1 ACTC1 CTNNB1
23 infratentorial cancer 10.1 CTNNB1 GLI1
24 asthma 10.1
25 chondroblastoma 10.1
26 gastric leiomyosarcoma 10.1
27 enchondroma 10.1
28 carcinosarcoma 10.0 ACTC1 CTNNB1
29 heart cancer 10.0 PTH1R SDHB
30 medulloblastoma 10.0 ACTC1 CTNNB1 GLI1
31 carpal tunnel syndrome 10.0
32 chordoma 10.0
33 osteoid osteoma 10.0
34 mononeuropathy of the median nerve, mild 10.0
35 hyperostosis 10.0
36 radiculopathy 10.0
37 epithelioid leiomyosarcoma 10.0
38 adenoma 10.0
39 neuropathy 10.0
40 multiple endocrine neoplasia, type iia 10.0 SDHB SDHD
41 dedifferentiated liposarcoma 10.0 ACTC1 HMGA2
42 multiple endocrine neoplasia 9.9 SDHB SDHC
43 smooth muscle tumor 9.9 ACTC1 HMGA2
44 atypical teratoid rhabdoid tumor 9.9 CTNNB1 HMGA2
45 cell type benign neoplasm 9.9 CTNNB1 HMGA2
46 diffuse lipomatosis 9.9 HMGA2 SDHB
47 neural crest tumor 9.9 SDHB SDHC SDHD
48 extra-adrenal pheochromocytoma 9.9 SDHB SDHC SDHD
49 pheochromocytoma 9.9 SDHB SDHC SDHD
50 adrenal medulla cancer 9.8 SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to Chondroma

Symptoms & Phenotypes for Chondroma

UMLS symptoms related to Chondroma:


pain

GenomeRNAi Phenotypes related to Chondroma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.5 CTNNB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.5 CTNNB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.5 SDHC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.5 CTNNB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.5 SDHC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.5 CTNNB1 SDHC
7 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.5 CTNNB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.5 CTNNB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.5 SDHC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.5 CTNNB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.5 CTNNB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.5 CTNNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.5 CTNNB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.5 SDHC

MGI Mouse Phenotypes related to Chondroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.7 ACTC1 CTNNB1 GLI1 PTH1R SDHB SDHC
2 endocrine/exocrine gland MP:0005379 9.65 CTNNB1 GLI1 PTH1R SDHB SDHD
3 neoplasm MP:0002006 9.35 CTNNB1 GLI1 PTH1R SDHB SDHD
4 normal MP:0002873 9.02 ACTC1 CTNNB1 GLI1 SDHB SDHD

Drugs & Therapeutics for Chondroma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
2 Low Grade Chondrosarcoma Versus Enchondroma Completed NCT02996747

Search NIH Clinical Center for Chondroma

Cochrane evidence based reviews: chondroma

Genetic Tests for Chondroma

Anatomical Context for Chondroma

MalaCards organs/tissues related to Chondroma:

41
Bone, Tongue, Lung, Heart, Lymph Node, Pancreas, Smooth Muscle

Publications for Chondroma

Articles related to Chondroma:

(show top 50) (show all 608)
# Title Authors Year
1
Massive Intradural Chondroma Masquerading as Lower Body Parkinsonism. ( 29581912 )
2018
2
Cervical Periosteal Chondroma Causing Spinal Cord or Nerve Compression: 2 Case Reports and Literature Review. ( 29550598 )
2018
3
Soft-Tissue Chondroma in the Preauricular Region: An Unusual Presentation. ( 29387304 )
2018
4
Intracranial chondroma without meningeal attachment. ( 29766963 )
2018
5
Periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism. ( 29413778 )
2018
6
Soft-Tissue Chondroma of Anterior Gingiva: A Rare Entity. ( 29725547 )
2018
7
Giant convexity chondroma with meningeal attachment. ( 29609117 )
2018
8
Extraskeletal chondroma walling the temporomandibular joint: Report of a rare case and review of the literature. ( 29966951 )
2018
9
Parotid gland chondroma masquerading as pleomorphic adenoma in fine needle aspiration cytology: A diagnostic challenge. ( 30144346 )
2018
10
Soft-tissue chondroma within the extensor tendon of the index finger in a child. ( 30033358 )
2018
11
Giant extraskeletal chondroma of the hand: A rare case. ( 30037203 )
2018
12
Soft Tissue Chondroma of the Eyelid. ( 30124612 )
2018
13
Breast chondroma. ( 30264439 )
2018
14
Intracranial Dural Parafalcine Chondroma: Case Report and Systematic Review of the Literature. ( 30273721 )
2018
15
Primary chondroma of posterior mediastinum with Horner's syndrome: a case report. ( 30333040 )
2018
16
Para-articular extraskeletal chondroma mimicking first metatarsophalangeal synovitis. ( 28828128 )
2017
17
Intracranial dural chondroma in a child-conventional and advanced neuroimaging characteristics and differential diagnosis. ( 28631961 )
2017
18
Soft tissue chondroma on the lip: Clinical, histopathological and ultrasonographic findings. ( 29115679 )
2017
19
Chondroma of the Bladder: An Atypical Localization. ( 29138708 )
2017
20
Synovial chondroma in Hoffa's fat pad: Case report and literature review of a rare disorder. ( 28130075 )
2017
21
Chondroma of the Sternum Growing in a Pregnant Patient: A Case Report. ( 28592723 )
2017
22
Giant convexity chondroma with dural involvement: Case report and review of literature. ( 28484562 )
2017
23
Trigger Finger Caused by Extraskeletal Chondroma. ( 27817941 )
2017
24
Extraskeletal Chondroma with Concomitant Arthrosis of the Foot at the First Metatarsophalangeal Joint<sub>A Case Report</sub>. ( 29252024 )
2017
25
Chondroma of the Bladder: A Case Report and Review of the Literature. ( 28479478 )
2017
26
Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice. ( 29106539 )
2017
27
Extraskeletal Chondroma of the Index Finger: A Case Report. ( 28690520 )
2017
28
A case of chondroma cutis showing callus-like appearance. ( 26932734 )
2016
29
Laryngeal Chondroma: An Unusual Complication Endotracheal Entubation. ( 27213734 )
2016
30
Breast Chondroma. ( 27797122 )
2016
31
Intradural chondroma in the cervical spine: case report. ( 27740393 )
2016
32
Case report of chondroma in a grass carp (Ctenopharyngodon idella). ( 27482364 )
2016
33
Periosteal chondroma with spinal cord compression in the thoracic spinal canal: a case report. ( 27179652 )
2016
34
Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature. ( 27602219 )
2016
35
Chondroma arising from the spinal dura mater at the thoracic level: A case report with molecular analysis. ( 27461824 )
2016
36
Is PET-CT an accurate method for the differential diagnosis between chondroma and chondrosarcoma? ( 27026930 )
2016
37
Intracranial dural based chondroma. ( 26602798 )
2016
38
Malignant transformation of a tracheal chondroma: The second reported case and review of the literature. ( 27185409 )
2016
39
Scrotal chondroma in a young male: A rare case report. ( 27166053 )
2016
40
Endobronchial chondroma: An unusual case of bronchial obstruction. ( 25770939 )
2015
41
Giant Dural Supratentorial Chondroma Generating the Question of How Large Can a Tumor Become Without Revealing Itself. ( 26918096 )
2015
42
Sellar Chondroma with Endocrine Dysfunction that Resolved after Surgery: Case Report. ( 26156668 )
2015
43
FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling. ( 26091072 )
2015
44
Extraskeletal Chondroma in the Popliteal Region: A Case Report. ( 26960310 )
2015
45
Primary spinal extraosseous cervical chondroma in an adult. ( 25751486 )
2015
46
A rare case of bladder chondroma. ( 25844100 )
2015
47
Nasal chondroma presenting as hypertelorism. ( 25730333 )
2015
48
Chondroma of Cerebral Falx: A Rare Intracranial Diagnosis. ( 26454394 )
2015
49
Periosteal chondroma of the femur: A case report and review of the literature. ( 25789014 )
2015
50
Orbital Chondroma: A rare mesenchymal tumor of orbit. ( 26265654 )
2015

Variations for Chondroma

Expression for Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for Chondroma

GO Terms for Chondroma

Cellular components related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.43 SDHB SDHC SDHD
2 protein-DNA complex GO:0032993 9.16 CTNNB1 HMGA2
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.69 ACTC1 CTNNB1 HMGA2
2 canonical Wnt signaling pathway GO:0060070 9.49 CTNNB1 GLI1
3 dorsal/ventral pattern formation GO:0009953 9.48 CTNNB1 GLI1
4 chondrocyte differentiation GO:0002062 9.46 HMGA2 PTH1R
5 epithelial to mesenchymal transition GO:0001837 9.43 CTNNB1 HMGA2
6 cell maturation GO:0048469 9.4 CTNNB1 PTH1R
7 aerobic respiration GO:0009060 9.37 SDHB SDHC
8 proximal/distal pattern formation GO:0009954 9.32 CTNNB1 GLI1
9 bone resorption GO:0045453 9.26 CTNNB1 PTH1R
10 regulation of osteoblast differentiation GO:0045667 9.16 CTNNB1 GLI1
11 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.96 SDHC SDHD
12 tricarboxylic acid cycle GO:0006099 8.8 SDHB SDHC SDHD

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
2 SMAD binding GO:0046332 9.26 CTNNB1 HMGA2
3 ubiquinone binding GO:0048039 9.13 SDHB SDHC SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.8 SDHB SDHC SDHD

Sources for Chondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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