MCID: CHN010
MIFTS: 43

Chondroma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Chondroma

MalaCards integrated aliases for Chondroma:

Name: Chondroma 12 77 54 56 45 15 74
Central Chondroma 12
Enchondroma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2602
MeSH 45 D002812
NCIt 51 C53459
SNOMED-CT 69 31186001

Summaries for Chondroma

Disease Ontology : 12 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

MalaCards based summary : Chondroma, also known as central chondroma, is related to juxtacortical chondroma and carney triad, and has symptoms including pain An important gene associated with Chondroma is SDHC (Succinate Dehydrogenase Complex Subunit C), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include tongue, bone and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing... more...

Related Diseases for Chondroma

Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 juxtacortical chondroma 33.4 CTNNB1 HMGA2
2 carney triad 32.4 PDGFRA SDHB SDHC SDHD
3 paragangliomas 1 31.3 SDHB SDHC SDHD
4 leiomyosarcoma 30.6 ACTC1 PDGFRA
5 paraganglioma 30.2 SDHB SDHC SDHD
6 gastric leiomyosarcoma 30.1 PDGFRA SDHD
7 glomus tumor 29.4 ACTC1 SDHB SDHD
8 pleomorphic adenoma 29.4 ACTC1 HMGA2
9 gastrointestinal stromal tumor 28.6 ACTC1 PDGFRA SDHB SDHC SDHD
10 extraskeletal chondroma 12.5
11 central nervous system chondroma 12.1
12 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 12.0
13 phalanx chondroma 12.0
14 carpotarsal osteochondromatosis 11.2
15 cartilage cancer 11.1
16 chondroid chordoma 11.1
17 chondrosarcoma 10.4
18 nonsyndromic paraganglioma 10.3
19 fibromatosis 10.3 ACTC1 CTNNB1
20 nodular medulloblastoma 10.2 CTNNB1 GLI1
21 pseudosarcomatous fibromatosis 10.2 ACTC1 CTNNB1
22 polymorphous low-grade adenocarcinoma 10.2 ACTC1 CTNNB1
23 infratentorial cancer 10.2 CTNNB1 GLI1
24 osteochondroma 10.1
25 desmoid tumor 10.1 CTNNB1 PDGFRA
26 pulmonary vein stenosis 10.1 ACTC1 PDGFRA
27 asthma 10.1
28 fibroma 10.1
29 chondroblastoma 10.1
30 enchondroma 10.1
31 carcinosarcoma 10.1 ACTC1 CTNNB1
32 multiple endocrine neoplasia 10.0 SDHB SDHC
33 carpal tunnel syndrome 10.0
34 chordoma 10.0
35 osteoid osteoma 10.0
36 mononeuropathy of the median nerve, mild 10.0
37 hyperostosis 10.0
38 radiculopathy 10.0
39 epithelioid leiomyosarcoma 10.0
40 adenoma 10.0
41 neuropathy 10.0
42 multiple endocrine neoplasia, type iia 9.9 SDHB SDHD
43 dermatofibrosarcoma protuberans 9.9 ACTC1 PDGFRA
44 dedifferentiated liposarcoma 9.9 ACTC1 HMGA2
45 smooth muscle tumor 9.9 ACTC1 HMGA2
46 diffuse lipomatosis 9.9 HMGA2 SDHB
47 lipomatosis 9.9 HMGA2 SDHB
48 atypical teratoid rhabdoid tumor 9.9 CTNNB1 HMGA2
49 rhabdomyosarcoma 9.9 ACTC1 GLI1 PDGFRA
50 cell type benign neoplasm 9.9 CTNNB1 HMGA2

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to Chondroma

Symptoms & Phenotypes for Chondroma

UMLS symptoms related to Chondroma:


pain

GenomeRNAi Phenotypes related to Chondroma according to GeneCards Suite gene sharing:

27 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.5 CTNNB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.5 CTNNB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.5 SDHC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.5 CTNNB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.5 SDHC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.5 CTNNB1 SDHC
7 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.5 CTNNB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.5 CTNNB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.5 SDHC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.5 CTNNB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.5 CTNNB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.5 CTNNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.5 CTNNB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.5 SDHC

MGI Mouse Phenotypes related to Chondroma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.7 ACTC1 CTNNB1 GLI1 PDGFRA SDHB SDHC
2 endocrine/exocrine gland MP:0005379 9.65 CTNNB1 GLI1 PDGFRA SDHB SDHD
3 neoplasm MP:0002006 9.35 CTNNB1 GLI1 PDGFRA SDHB SDHD
4 normal MP:0002873 9.1 ACTC1 CTNNB1 GLI1 PDGFRA SDHB SDHD

Drugs & Therapeutics for Chondroma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
2 Low Grade Chondrosarcoma Versus Enchondroma Completed NCT02996747

Search NIH Clinical Center for Chondroma

Cochrane evidence based reviews: chondroma

Genetic Tests for Chondroma

Anatomical Context for Chondroma

MalaCards organs/tissues related to Chondroma:

42
Tongue, Bone, Lung, Spinal Cord, Breast, Trachea, Brain

Publications for Chondroma

Articles related to Chondroma:

(show top 50) (show all 613)
# Title Authors Year
1
Rare case of bladder chondroma causing lower urinary tract symptoms. ( 30661043 )
2019
2
Transsphenoidal Removal of Retroclival Chondroma with Pituitary Transposition Manifesting as Repeated Subarachnoid Hemorrhage: A Case Report. ( 30708387 )
2019
3
Chondroma of the Tongue. ( 30845089 )
2019
4
Massive Intradural Chondroma Masquerading as Lower Body Parkinsonism. ( 29581912 )
2018
5
Cervical Periosteal Chondroma Causing Spinal Cord or Nerve Compression: 2 Case Reports and Literature Review. ( 29550598 )
2018
6
Soft-Tissue Chondroma in the Preauricular Region: An Unusual Presentation. ( 29387304 )
2018
7
Intracranial chondroma without meningeal attachment. ( 29766963 )
2018
8
Periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism. ( 29413778 )
2018
9
Soft-Tissue Chondroma of Anterior Gingiva: A Rare Entity. ( 29725547 )
2018
10
Giant convexity chondroma with meningeal attachment. ( 29609117 )
2018
11
Extraskeletal chondroma walling the temporomandibular joint: Report of a rare case and review of the literature. ( 29966951 )
2018
12
Parotid gland chondroma masquerading as pleomorphic adenoma in fine needle aspiration cytology: A diagnostic challenge. ( 30144346 )
2018
13
Soft-tissue chondroma within the extensor tendon of the index finger in a child. ( 30033358 )
2018
14
Giant extraskeletal chondroma of the hand: A rare case. ( 30037203 )
2018
15
Soft Tissue Chondroma of the Eyelid. ( 30124612 )
2018
16
Breast chondroma. ( 30264439 )
2018
17
Intracranial Dural Parafalcine Chondroma: Case Report and Systematic Review of the Literature. ( 30273721 )
2018
18
Primary chondroma of posterior mediastinum with Horner's syndrome: a case report. ( 30333040 )
2018
19
Two Cases of Cartilaginous Choristoma-Not Chondroma of the Bony External Auditory Canal. ( 30652042 )
2018
20
Computed Tomography Imaging Findings of Pulmonary Chondroma. ( 30687744 )
2018
21
Para-articular extraskeletal chondroma mimicking first metatarsophalangeal synovitis. ( 28828128 )
2017
22
Intracranial dural chondroma in a child-conventional and advanced neuroimaging characteristics and differential diagnosis. ( 28631961 )
2017
23
Soft tissue chondroma on the lip: Clinical, histopathological and ultrasonographic findings. ( 29115679 )
2017
24
Chondroma of the Bladder: An Atypical Localization. ( 29138708 )
2017
25
Synovial chondroma in Hoffa's fat pad: Case report and literature review of a rare disorder. ( 28130075 )
2017
26
Chondroma of the Sternum Growing in a Pregnant Patient: A Case Report. ( 28592723 )
2017
27
Giant convexity chondroma with dural involvement: Case report and review of literature. ( 28484562 )
2017
28
Trigger Finger Caused by Extraskeletal Chondroma. ( 27817941 )
2017
29
Extraskeletal Chondroma with Concomitant Arthrosis of the Foot at the First Metatarsophalangeal Joint<sub>A Case Report</sub>. ( 29252024 )
2017
30
Chondroma of the Bladder: A Case Report and Review of the Literature. ( 28479478 )
2017
31
Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice. ( 29106539 )
2017
32
Extraskeletal Chondroma of the Index Finger: A Case Report. ( 28690520 )
2017
33
A case of chondroma cutis showing callus-like appearance. ( 26932734 )
2016
34
Laryngeal Chondroma: An Unusual Complication Endotracheal Entubation. ( 27213734 )
2016
35
Breast Chondroma. ( 27797122 )
2016
36
Intradural chondroma in the cervical spine: case report. ( 27740393 )
2016
37
Case report of chondroma in a grass carp (Ctenopharyngodon idella). ( 27482364 )
2016
38
Periosteal chondroma with spinal cord compression in the thoracic spinal canal: a case report. ( 27179652 )
2016
39
Pulmonary chondroma: A clinicopathological study of 29 cases and a review of the literature. ( 27602219 )
2016
40
Chondroma arising from the spinal dura mater at the thoracic level: A case report with molecular analysis. ( 27461824 )
2016
41
Is PET-CT an accurate method for the differential diagnosis between chondroma and chondrosarcoma? ( 27026930 )
2016
42
Intracranial dural based chondroma. ( 26602798 )
2016
43
Malignant transformation of a tracheal chondroma: The second reported case and review of the literature. ( 27185409 )
2016
44
Scrotal chondroma in a young male: A rare case report. ( 27166053 )
2016
45
Endobronchial chondroma: An unusual case of bronchial obstruction. ( 25770939 )
2015
46
Giant Dural Supratentorial Chondroma Generating the Question of How Large Can a Tumor Become Without Revealing Itself. ( 26918096 )
2015
47
Sellar Chondroma with Endocrine Dysfunction that Resolved after Surgery: Case Report. ( 26156668 )
2015
48
FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling. ( 26091072 )
2015
49
Extraskeletal Chondroma in the Popliteal Region: A Case Report. ( 26960310 )
2015
50
Primary spinal extraosseous cervical chondroma in an adult. ( 25751486 )
2015

Variations for Chondroma

Expression for Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for Chondroma

GO Terms for Chondroma

Cellular components related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-DNA complex GO:0032993 9.16 CTNNB1 HMGA2
2 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.71 ACTC1 CTNNB1 HMGA2
2 negative regulation of apoptotic process GO:0043066 9.58 ACTC1 CTNNB1 HMGA2
3 canonical Wnt signaling pathway GO:0060070 9.52 CTNNB1 GLI1
4 odontogenesis of dentin-containing tooth GO:0042475 9.51 CTNNB1 PDGFRA
5 dorsal/ventral pattern formation GO:0009953 9.49 CTNNB1 GLI1
6 epithelial to mesenchymal transition GO:0001837 9.48 CTNNB1 HMGA2
7 aerobic respiration GO:0009060 9.46 SDHB SDHC
8 proximal/distal pattern formation GO:0009954 9.43 CTNNB1 GLI1
9 cardiac myofibril assembly GO:0055003 9.37 ACTC1 PDGFRA
10 lung development GO:0030324 9.33 CTNNB1 GLI1 PDGFRA
11 male genitalia development GO:0030539 9.32 CTNNB1 PDGFRA
12 regulation of osteoblast differentiation GO:0045667 9.26 CTNNB1 GLI1
13 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.96 SDHC SDHD
14 tricarboxylic acid cycle GO:0006099 8.8 SDHB SDHC SDHD

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
2 SMAD binding GO:0046332 9.26 CTNNB1 HMGA2
3 ubiquinone binding GO:0048039 8.96 SDHB SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.8 SDHB SDHC SDHD

Sources for Chondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....