Chondroma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Chondroma

MalaCards integrated aliases for Chondroma:

Name: Chondroma ¹¹ ¹⁹ ⁷⁵ ⁵³ ⁴³ ¹⁴ ⁷¹ ⁷⁵

Central Chondroma ¹¹

Enchondroma ⁷¹

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:2602

MeSH ⁴³ D002812

NCIt ⁴⁹ C53459

SNOMED-CT ⁶⁸ 269638002

UMLS ⁷¹ C0936248 C1704356

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Summaries for Chondroma

GARD: ¹⁹ A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)

MalaCards based summary: Chondroma, also known as central chondroma, is related to soft tissue chondroma and carney triad, and has symptoms including pain An important gene associated with Chondroma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Disease and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Affiliated tissues include bone, tongue and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Decreased viability in pancreas lineage

Disease Ontology: ¹¹ A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

Wikipedia: ⁷⁵ A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing... more...

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Related Diseases for Chondroma

Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 383)

#	Related Disease	Score	Top Affiliating Genes
1	soft tissue chondroma	32.5	HMGA2 ACVR2A
2	carney triad	31.5	SDHD SDHC SDHB SDHA PDGFRA KIT
3	paragangliomas 1	31.5	SDHD SDHC SDHB SDHA
4	juxtacortical chondroma	31.5	IDH2 IDH1 EXT2
5	chondroblastoma	30.5	S100A1 CTNNB1 ANO1
6	epithelioid leiomyosarcoma	30.4	KIT ANO1 ACTC1
7	enchondroma	30.3	IDH2 IDH1
8	fibroma	30.2	S100A1 NF1 FN1 CTNNB1 ACTC1
9	leiomyoma	30.0	S100A1 KIT HMGA2 ACTC1
10	pleomorphic adenoma	30.0	S100A1 HMGA2 FN1 CTNNB1 ACTC1
11	horner's syndrome	30.0	SDHD SDHB NF1
12	leiomyosarcoma	29.9	S100A1 PDGFRA NF1 KIT HMGA2 ACTC1
13	chondrosarcoma	29.9	S100A1 PDGFRA IDH2 IDH1 EXT2
14	meningioma, familial	29.9	NF1 KIT IDH1 GLI1 CTNNB1
15	sarcoma	29.8	S100A1 PDGFRA KIT GLI1 CTNNB1 ACTC1
16	sarcoma, synovial	29.7	NF1 KIT HMGA2 CTNNB1
17	enchondromatosis, multiple, ollier type	29.7	IDH2 IDH1 EXT2
18	fibrosarcoma	29.7	PDGFRA KIT FN1 ACTC1
19	chordoma	29.6	S100A1 PDGFRA IDH2 IDH1 CTNNB1
20	lipomatosis, multiple	29.5	S100A1 NF1 KIT HMGA2 ANO1
21	hemangioma	29.5	KIT IDH1 CTNNB1 ACTC1
22	intracranial chondrosarcoma	29.5	IDH2 IDH1
23	connective tissue benign neoplasm	29.4	NF1 KIT CTNNB1 ANO1
24	mesenchymal cell neoplasm	29.4	PDGFRA NF1 KIT HMGA2 CTNNB1 ANO1
25	gastrointestinal stromal tumor	29.4	SDHD SDHC SDHB SDHAF2 SDHA S100A1
26	periosteal chondrosarcoma	29.4	IDH2 IDH1 EXT2
27	gastric leiomyosarcoma	29.3	SDHD SDHC SDHB SDHA PDGFRA KIT
28	neurofibroma	29.3	S100A1 PDGFRA NF1 KIT ACTC1
29	paraganglioma	29.2	SDHD SDHC SDHB SDHAF2 SDHA NF1
30	neurilemmoma	29.2	S100A1 PDGFRA NF1 KIT ANO1 ACTC1
31	hereditary paraganglioma-pheochromocytoma syndromes	28.9	SDHD SDHC SDHB SDHAF2 SDHA NF1
32	spinal cord disease	28.9	PDGFRA NF1 IDH2 IDH1
33	glomus tumor	28.8	SDHD SDHB S100A1 NF1 KIT ANO1
34	central nervous system chondroma	11.1
35	chondroid chordoma	11.0
36	phalanx chondroma	11.0
37	cartilage cancer	10.9
38	cervicofacial fibrochondroma	10.9
39	short stature, onychodysplasia, facial dysmorphism, and hypotrichosis	10.5
40	sporadic pheochromocytoma/secreting paraganglioma	10.3	SDHD SDHB
41	paragangliomas 4	10.3	SDHD SDHB
42	osteochondroma	10.3
43	carotid body cancer	10.3	SDHD SDHB
44	scrotum melanoma	10.3	SDHD SDHA
45	cowden syndrome 4	10.3	SDHC SDHB
46	rare tumor	10.3
47	trachea leiomyoma	10.3	S100A1 GLI1
48	eosinophilic variant of chromophobe renal cell carcinoma	10.2	S100A1 KIT
49	cartilage disease	10.2
50	mitochondrial complex ii deficiency, nuclear type 1	10.2	SDHD SDHA

Graphical network of the top 20 diseases related to Chondroma:

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Symptoms & Phenotypes for Chondroma

UMLS symptoms related to Chondroma:

pain

GenomeRNAi Phenotypes related to Chondroma according to GeneCards Suite gene sharing:

²⁵ (show all 28)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.18	ACTC1 ACVR2A ANO1 CTNNB1 EXT2 FN1
2	no effect	GR00402-S-2	10.18	ACTC1 ACVR2A ANO1 CTNNB1 FN1 GLI1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-112	10.07	IDH1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	10.07	IDH1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-129	10.07	PDGFRA
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-136	10.07	IDH1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	10.07	IDH1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-146	10.07	PDGFRA
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	10.07	KIT
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	10.07	KIT
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-167	10.07	PDGFRA
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-170	10.07	KIT
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-172	10.07	IDH1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-18	10.07	IDH1 PDGFRA
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-204	10.07	PDGFRA
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-207	10.07	PDGFRA
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	10.07	KIT
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	10.07	PDGFRA
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-39	10.07	IDH1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	10.07	CTNNB1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	10.07	PDGFRA
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-61	10.07	KIT
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-77	10.07	PDGFRA
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.07	KIT
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-86	10.07	PDGFRA
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	10.07	KIT
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	10.07	KIT
28	Decreased viability in pancreas lineage	GR00235-A	9.16	GLI1 IDH1

MGI Mouse Phenotypes related to Chondroma:

⁴⁵ (show all 19)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.39	ACTC1 ACVR2A ANO1 CTNNB1 FN1 HMGA2
2	nervous system	MP:0003631	10.37	ACTC1 ACVR2A ANO1 CTNNB1 FN1 GLI1
3	growth/size/body region	MP:0005378	10.37	ACTC1 ACVR2A ANO1 CTNNB1 FN1 GLI1
4	neoplasm	MP:0002006	10.32	CTNNB1 FN1 GLI1 HMGA2 IDH2 KIT
5	normal	MP:0002873	10.27	ACTC1 CTNNB1 FN1 GLI1 KIT NF1
6	cellular	MP:0005384	10.25	ACTC1 ACVR2A CTNNB1 FN1 GLI1 HMGA2
7	muscle	MP:0005369	10.19	ACTC1 ANO1 CTNNB1 FN1 KIT NF1
8	embryo	MP:0005380	10.18	ACVR2A CTNNB1 EXT2 FN1 GLI1 KIT
9	renal/urinary system	MP:0005367	10.15	ANO1 CTNNB1 GLI1 HMGA2 KIT NF1
10	behavior/neurological	MP:0005386	10.13	ACTC1 ANO1 CTNNB1 GLI1 HMGA2 KIT
11	cardiovascular system	MP:0005385	10.11	ACTC1 ACVR2A ANO1 CTNNB1 FN1 IDH2
12	craniofacial	MP:0005382	10.09	ACVR2A CTNNB1 FN1 GLI1 HMGA2 KIT
13	limbs/digits/tail	MP:0005371	10.07	CTNNB1 FN1 GLI1 HMGA2 KIT NF1
14	digestive/alimentary	MP:0005381	10.06	ACVR2A ANO1 CTNNB1 GLI1 HMGA2 KIT
15	skeleton	MP:0005390	10	ACVR2A ANO1 CTNNB1 EXT2 FN1 GLI1
16	pigmentation	MP:0001186	9.98	ACVR2A CTNNB1 KIT NF1 PDGFRA
17	respiratory system	MP:0005388	9.91	ACVR2A ANO1 CTNNB1 GLI1 IDH1 KIT
18	hematopoietic system	MP:0005397	9.73	ACTC1 ACVR2A CTNNB1 FN1 IDH1 IDH2
19	mortality/aging	MP:0010768	9.55	ACTC1 ACVR2A ANO1 CTNNB1 EXT2 FN1

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Drugs & Therapeutics for Chondroma

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Phase II, Placebo-controlled, Multicenter Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas	Recruiting	NCT02389244	Phase 2	Regorafenib;Placebo
2	Low Grade Chondrosarcoma Versus Enchondroma: Challenges in Diagnosis and Management	Completed	NCT02996747

Search NIH Clinical Center for Chondroma

Cochrane evidence based reviews: chondroma

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Genetic Tests for Chondroma

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Anatomical Context for Chondroma

Organs/tissues related to Chondroma:

MalaCards : Bone, Tongue, Spinal Cord, Lung, Trachea, Occipital Lobe, Thyroid

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Publications for Chondroma

Articles related to Chondroma:

(show top 50) (show all 1587)

#	Title	Authors	PMID	Year
1	Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. ⁵³ ⁶²	Dahlen A...Panagopoulos I	14614053	2003
2	Rapidly growing proliferative pulmonary chondroma: A case report. ⁶²	Uchida T...Nakajima H	36434873	2022
3	Hondrosarcoma of the chest with intraabdominal distribution (case report). ⁶²	Smetanina SV...Derzhavin VA	36099459	2022
4	Extraskeletal Osteochondroma in the Posterior Neck of a Middle-Aged Female: A Case Report. ⁶²	Lea WW...Jeon TS	36276210	2022
5	Unusual chondroblastoma of the hand with large extraosseous soft tissue component. ⁶²	Choi J...Bindra J	35814820	2022
6	Differentiation of Skull Base Chondrosarcomas, Chordomas, and Metastases: Utility of DWI and Dynamic Contrast-Enhanced Perfusion MR Imaging. ⁶²	Ota Y...Srinivasan A	35953276	2022
7	Periosteal chondroma of the rib: A case report. ⁶²	Gao Y...Gao CP	36159509	2022
8	[Skin chondroma of neck in children: report of a case]. ⁶²	Wang JJ...Li CT	35673737	2022
9	About a misleading calcified mass of the elbow: Soft tissue osteochondroma: A case report. ⁶²	Ammar A...Smida M	35662034	2022
10	Imaging characteristics of slow-growing soft tissue chondroma of the tongue: A case report. ⁶²	Park Y...Kim JH	35583538	2022
11	Chondroma of the urinary bladder: A case report. ⁶²	Kao KW...Chang YC	35608424	2022
12	Endobronchial Chondroma: A Rare Case of Benign Tumor With Atypical High Standardized Uptake Value. ⁶²	Assaad M...El-Sayegh D	35686284	2022
13	[Soft tissue tumours with FN1 (Fibronectin 1) fusion gene]. ⁶²	Bouvier C...Macagno N	35181149	2022
14	Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) of the Foot: A Case Report and Literature Review of Nora's Lesion of the Foot. ⁶²	Basdelioglu K...Ozkan K	35602798	2022
15	Intraspinal periosteal chondroma in upper thoracic spine causing cord compression and myelopathy: A case report. ⁶²	Khadka R...Shilpakar SK	35378407	2022
16	Arthroscopic surgery for synovial chondroma of the subacromial bursa with non-traumatic shoulder subluxation complications: Two case reports. ⁶²	Tang XF...Li YZ	35211605	2022
17	[Soft tissue chondroma of the liver: report of a case]. ⁶²	Wang MP...Lyu M	35152637	2022
18	Thorahcic SMARCA4-deficient undifferentiated tumors with ganglioneuroma and enchondroma: implications for SLC7A11 and ARID1A expression: a case report. ⁶²	Kito Y...Takeuchi T	35151345	2022
19	Histopathological pattern of primary bone tumours at the Black Lion Specialized Hospital, Addis Ababa, Ethiopia: a retrospective cross-sectional, 2015-2019. ⁶²	Weyessa TG...Yefter ET	35371378	2022
20	Clinical and Imaging Features of Tumors in the Scapula. ⁶²	Song Y...Gao BL	34488589	2022
21	Imaging Diagnosis of Primary Solitary Bone Neoplasts and Its Comparison with Tumor-like Lesions. ⁶²	Wei X...Tang W	35990818	2022
22	Soft Tissue Chondroma: A Possible Diagnosis of Single-Digit Nail Clubbing. ⁶²	Xue S...Haneke E	34904580	2022
23	Soft tissue chondroma of the plantar foot in a 14-year-old boy: a case report. ⁶²	Benradi L...Belahcen M	34959092	2022
24	Dural Convexity Chondroma Mimicking Meningioma in a Young Female. ⁶²	Sarathy D...Syed HR	35106249	2021
25	Carney's triad in an adult male from a tertiary care center in India: a case report. ⁶²	Tansir G...Rastogi S	34782012	2021
26	Chondroblastoma-Like Soft-Tissue Chondroma of the Hand: A Case Report. ⁶²	AlYami AH	34912609	2021
27	[Orbital chondroma (about a case)]. ⁶²	Bouchaar M...Oubaaz A	34544595	2021
28	Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling. ⁶²	Hruba E...Buchtova M	34423857	2021
29	Primary soft tissue chondroma of the posterior mediastinum: a rare case report and literature review. ⁶²	Fang S...Liu J	34686095	2021
30	RCAN1.4 suppresses the osteosarcoma growth and metastasis via interfering with the calcineurin/NFAT signaling pathway. ⁶²	Huang B...Liu J	34336566	2021
31	SDHC Methylation Pattern in Patients With Carney Triad. ⁶²	Daumova M...Daum O	33624983	2021
32	Low-grade chondrosarcoma of the larynx: A case report. ⁶²	Vuckovic L...Culafic T	34621830	2021
33	Novel Use of Ultrasonic Aspirator Device for Cricoid Chondroma Resection. ⁶²	Bhatt NK...O'Dell K	33107630	2021
34	Periosteal Chondroma of the Pelvis: An Uncommon Tumor in an Unusual Location. ⁶²	Prabhakar G...Rajani R	34548974	2021
35	Unusual Anterior Mediastinal Tumors Treated at a Tertiary Thoracic Center: A Case Series Analysis. ⁶²	Kumar A...Mishra A	34646675	2021
36	The Application of Arthroscopic Techniques in the Diagnosis and Treatment of Hip-Related Conditions in China. ⁶²	Zhao FY...Wang JQ	34351067	2021
37	"Slipped capital femoral epiphysis in a 25-year-old hypogonadic man with a large cranial chondroma: causality or coincidence? ". ⁶²	Sawicka-Gutaj N...Ruchala M	34404399	2021
38	Pelvic chodroma in the left obturator foramen: The first case report. ⁶²	Swed S...Alyousfi R	34388900	2021
39	Extra-articular tenosynovial chondromatosis of the right fifth digit in a 59-year-old man: A case report and literature review. ⁶²	Qi-Huang S...Weingarten E	35586796	2021
40	Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis. ⁶²	Liu YJ...Chen EY	33727696	2021
41	Resection of Huge Nasal Septal Chondroma Via Endoscopic Septoplasty Approach Through Modified Killian Incision. ⁶²	Kwak HH...Cho KS	34130516	2021
42	Congenital laryngeal chondroma. ⁶²	Quere J...Marianowski R	32811795	2021
43	Intracortical chondroma of the metacarpal bone: A case report. ⁶²	Yoshida Y...Nagura T	33969092	2021
44	[CT and Magnetic Resonance Imaging Findings of the Intracranial Extra-cerebral Chondroma:A Case Report]. ⁶²	Meng QL...Chen ZY	33966714	2021
45	Acral FibroChondroMyxoid tumor: imaging features of a new entity. ⁶²	Le Corroller T...Bouvier C	32844242	2021
46	A case of Carney triad complicated by renal cell carcinoma and a germline SDHA pathogenic variant. ⁶²	Wurth R...Hannah-Shmouni F	33839693	2021
47	Carney triad: A case report, characteristics and literature review of this rare entity. ⁶²	Fraile Alonso I...Lopez Pardo R	33422846	2021
48	Falcine chondroma: illustrative case. ⁶²	Chua MMJ...Saris SC	36045938	2021
49	Case report: Rare convexity meningeal chondroma mimicking a meningioma. ⁶²	Abreu PG...Correia JP	34513189	2021
50	Hand tumors: A review of 186 patients at a single institute. ⁶²	Fujibuchi T...Miura H	33624536	2021

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Genes for Chondroma

Genes related to Chondroma (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	14.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19522821
2	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	14.27	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19522821
3	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	14.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19522821
4	CTNNB1	Catenin Beta 1	Protein Coding	11.78	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	GLI1	GLI Family Zinc Finger 1	Protein Coding	10.79	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	10.57	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14614053
7	FN1	Fibronectin 1	Protein Coding	10.45	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
8	ACVR2A	Activin A Receptor Type 2A	Protein Coding	10.08	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
9	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	7.3	GeneCards inferred via : Publications (show sections)
10	S100A1	S100 Calcium Binding Protein A1	Protein Coding	7.3	GeneCards inferred via : Publications (show sections)
11	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	7.3	DISEASES inferred ¹⁴
12	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	7.13	DISEASES inferred ¹⁴
13	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	6.73	DISEASES inferred ¹⁴
14	ANO1	Anoctamin 1	Protein Coding	6.35	DISEASES inferred ¹⁴
15	NF1	Neurofibromin 1	Protein Coding	6.22	DISEASES inferred ¹⁴
16	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	5.98	DISEASES inferred ¹⁴
17	EXT2	Exostosin Glycosyltransferase 2	Protein Coding	5.92	DISEASES inferred ¹⁴
18	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	5.91	DISEASES inferred ¹⁴
19	IDH2	Isocitrate Dehydrogenase (NADP(+)) 2	Protein Coding	5.9	DISEASES inferred ¹⁴

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Variations for Chondroma

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Expression for Chondroma

Search GEO for disease gene expression data for Chondroma.

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Pathways for Chondroma

Pathways related to Chondroma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.49	S100A1 PDGFRA NF1 KIT IDH1 FN1
2	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁶ Show member pathways Electron transport chain: OXPHOS system in mitochondria ⁷⁴ Mitochondrial Uncoupling ⁶⁶ Oleoyl-phe metabolism ⁶⁶ Oxidative phosphorylation ⁷⁴ Respiratory electron transport ⁶⁶ The citric acid (TCA) cycle and respiratory electron transport ⁶⁶	12.59	SDHD SDHC SDHB SDHA IDH2
3	Glucose / Energy Metabolism ³	12.27	SDHAF2 SDHA IDH2 IDH1
4	Malignant pleural mesothelioma ⁷⁴	12.27	PDGFRA KIT FN1 CTNNB1 ACTC1
5	glycolysis (BioCyc) ⁶¹ Show member pathways Aerobic glycolysis ⁷⁴ glycolysis ⁶¹ Glycolysis and gluconeogenesis ⁷⁴ Glycolysis and gluconeogenesis (short map) ²² glycolysis III (from glucose) ⁶¹ homolactic fermentation ⁶¹ Manipulation of host energy metabolism ⁶⁶	12	SDHA SDHB SDHC SDHD
6	Hippo-Merlin signaling dysregulation ⁷⁴ Show member pathways Hippo signaling regulation pathways ⁷⁴	11.59	PDGFRA KIT CTNNB1
7	Pyruvate metabolism ⁶⁶ Show member pathways Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁶ pyruvate decarboxylation to acetyl CoA ⁶¹ Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁶ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁶	11.59	SDHD SDHC SDHB SDHA IDH2
8	TCA cycle III (animals) ⁶¹ Show member pathways Citric acid cycle (TCA cycle) ⁶⁶ TCA cycle ⁶¹ TCA cycle (aka Krebs or citric acid cycle) ⁷⁴ TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc) ⁷⁴	11.38	SDHD SDHC SDHB SDHA IDH2 IDH1
9	Cardiac progenitor differentiation ⁷⁴	11.22	PDGFRA KIT ACTC1
10	Mitochondrial complex II assembly ⁷⁴ Show member pathways aerobic respiration I (cytochrome c) ⁶¹	10.1	SDHD SDHC SDHB SDHAF2 SDHA

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GO Terms for Chondroma

Cellular components related to Chondroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	9.23	SDHD SDHC SDHB SDHA

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	odontogenesis of dentin-containing tooth	GO:0042475	9.93	PDGFRA CTNNB1 ACVR2A
2	chondrocyte differentiation	GO:0002062	9.91	HMGA2 EXT2 CTNNB1
3	proton motive force-driven mitochondrial ATP synthesis	GO:0042776	9.76	SDHA SDHB SDHC SDHD
4	isocitrate metabolic process	GO:0006102	9.71	IDH2 IDH1
5	succinate metabolic process	GO:0006105	9.67	SDHB SDHA
6	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	9.65	SDHD SDHC SDHB SDHAF2 SDHA
7	mast cell proliferation	GO:0070662	9.62	NF1 KIT
8	glyoxylate cycle	GO:0006097	9.56	IDH2 IDH1
9	tricarboxylic acid cycle	GO:0006099	9.47	SDHD SDHC SDHB SDHAF2 SDHA IDH2

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ubiquinone binding	GO:0048039	9.62	SDHD SDHB
2	isocitrate dehydrogenase (NADP+) activity	GO:0004450	9.56	IDH2 IDH1
3	electron transfer activity	GO:0009055	9.56	SDHD SDHC SDHB SDHA
4	succinate dehydrogenase activity	GO:0000104	9.46	SDHC SDHA
5	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.1	SDHD SDHB SDHA

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Sources for Chondroma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CHN010 MIFTS: 43	Chondroma Categories: Bone diseases, Cancer diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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